TDMS Study 05094-03 Pathology Tables
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
CORE ANIMALS
Facility: Southern Research Institute
Chemical CAS #: 85-68-7
Lock Date: 11/25/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25004 Dead
25003 Moribund 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|
DAY ON TEST | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|
| 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
CONTROL | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + A + + + + + A A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + I + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + I + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + A A + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|
DAY ON TEST | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|
| 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
CONTROL | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | |
Polyp Stromal, Multiple | |
Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + M + |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X X X X|
Pancreatic, Leukemia Mononuclear | X X X X X X X |
Popliteal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|
DAY ON TEST | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|
| 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
CONTROL | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Squamous Cell Papilloma | X |
Sebaceous Gland, Basal Cell Adenoma | X |
Subcutaneous Tissue, Fibroma | X X|
Subcutaneous Tissue, Fibroma, | |
Multiple | |
Subcutaneous Tissue, Melanoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Carcinoma, Metastatic, Pituitary | |
Gland | |
Ependymoma Malignant | |
Glioma Malignant | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X|
Sarcoma, Metastatic, Tissue NOS | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|
DAY ON TEST | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|
| 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
CONTROL | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | + + |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|
DAY ON TEST | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|
| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + I + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + I + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|
DAY ON TEST | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|
| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Polyp Stromal | X X X |
Polyp Stromal, Multiple | |
Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | M M M M M M M M |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | X X X X |
Deep Cervical, Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X X X X X X |
Inguinal, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X X X X X X X |
Pancreatic, Leukemia Mononuclear | X X X X X X X |
Popliteal, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|
DAY ON TEST | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|
| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X X X|
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X X |
Squamous Cell Papilloma | |
Sebaceous Gland, Basal Cell Adenoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibroma, | |
Multiple | |
Subcutaneous Tissue, Melanoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Ependymoma Malignant | X |
Glioma Malignant | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X |
Sarcoma, Metastatic, Tissue NOS | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|
DAY ON TEST | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|
| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| | |
DAY ON TEST | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| | |
| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
UNTREATD | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + M + + | 63 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + M + + + + + + | 64 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 64 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 65 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X | 38 |
__________________________________________________________________________|____________|
Mesentery | | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 62 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 64 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + M | 62 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + M | 63 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X X X X | 23 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 63 |
Leukemia Mononuclear | X X | 13 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| | |
DAY ON TEST | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| | |
| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
UNTREATD | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 62 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + + + + + + | 63 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X X | 13 |
Pars Distalis, Adenoma | X X X X X X X X X | 26 |
Pars Distalis, Adenoma, Multiple | | 2 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 64 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 6 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + | 65 |
Adenoma | X X | 6 |
Carcinoma | X X | 5 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 65 |
Granulosa Cell Tumor Benign | | 1 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X | 5 |
Polyp Stromal | | 3 |
Polyp Stromal, Multiple | X | 1 |
Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | M | 2 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X X X X X X X | 31 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 29 |
Axillary, Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| | |
DAY ON TEST | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| | |
| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
UNTREATD | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Deep Cervical, Leukemia Mononuclear | X X | 4 |
Iliac, Leukemia Mononuclear | X X | 9 |
Inguinal, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | X X X X X X | 19 |
Pancreatic, Leukemia Mononuclear | X X X X X X | 20 |
Popliteal, Leukemia Mononuclear | X | 2 |
Renal, Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 64 |
Leukemia Mononuclear | X X X X X X | 28 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X X X X X X | 26 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X X X X X X X X | 36 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + + | 64 |
Leukemia Mononuclear | X X X | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 64 |
Carcinoma | X X | 5 |
Fibroadenoma | X X X X | 18 |
Fibroadenoma, Multiple | X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 65 |
Keratoacanthoma | | 2 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Basal Cell Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 3 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | X | 1 |
Subcutaneous Tissue, Melanoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 65 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 65 |
Astrocytoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| | |
DAY ON TEST | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| | |
| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
UNTREATD | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Ependymoma Malignant | | 1 |
Glioma Malignant | | 1 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 65 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 24 |
Sarcoma, Metastatic, Tissue NOS | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 65 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X X X | 19 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + | 64 |
Leukemia Mononuclear | X | 2 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X X X X X X X X X X | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|
DAY ON TEST | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|
| 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Mesothelioma NOS | |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
Lipoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | + + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|
DAY ON TEST | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|
| 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Polyp Stromal | X X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X X X X X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Mesothelioma NOS | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|
DAY ON TEST | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|
| 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X |
Oligodendroglioma Malignant | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Transitional Epithelium, Carcinoma | X |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|
DAY ON TEST | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|
| 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|
DAY ON TEST | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|
| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Mesothelioma NOS | X |
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X X |
Lipoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Tooth | + |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|
DAY ON TEST | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|
| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Polyp Stromal | X X |
__________________________________________________________________________|
Vagina | M M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X X X X |
Pancreatic, Leukemia Mononuclear | X X X X X X X X X |
Renal, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X|
Mesothelioma NOS | X |
__________________________________________________________________________|
Thymus | + + + M + + M + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|
DAY ON TEST | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|
| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + M + + + + + + + +|
Astrocytoma Malignant | X |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X |
Oligodendroglioma Malignant | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Transitional Epithelium, Carcinoma | |
Transitional Epithelium, Papilloma | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|
DAY ON TEST | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|
| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma NOS | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| | |
DAY ON TEST | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| | |
| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2.4% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + | 61 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | | 3 |
Leukemia Mononuclear | X X X X X X X X X X | 42 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Leukemia Mononuclear | | 2 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X | 9 |
Acinus, Adenoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Odontoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X X X | 23 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + | 61 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| | |
DAY ON TEST | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| | |
| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2.4% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 16 |
Pheochromocytoma Benign | X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + | 61 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 6 |
Pars Distalis, Adenoma | X X X | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 61 |
C-Cell, Adenoma | | 5 |
Follicular Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + | 60 |
Adenoma | | 2 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X | 3 |
Polyp Stromal | X X | 8 |
__________________________________________________________________________|____________|
Vagina | M | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X X X X X | 31 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 23 |
Axillary, Leukemia Mononuclear | | 3 |
Deep Cervical, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | X X | 5 |
Inguinal, Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | X X X | 12 |
Pancreatic, Leukemia Mononuclear | X X X X | 19 |
Renal, Leukemia Mononuclear | X X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X X X | 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| | |
DAY ON TEST | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| | |
| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2.4% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X X X | 24 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X X X X X X X X X | 46 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + | 57 |
Leukemia Mononuclear | X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + | 61 |
Carcinoma | | 1 |
Fibroadenoma | X X | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 61 |
Keratoacanthoma | | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Rhabdomyosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 60 |
Astrocytoma Malignant | | 1 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | X | 4 |
Oligodendroglioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 61 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | X X X X | 21 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 61 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 61 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| | |
DAY ON TEST | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| | |
| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
2.4% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X X X | 21 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | | 2 |
Transitional Epithelium, Carcinoma | X X X | 4 |
Transitional Epithelium, Papilloma | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + | 61 |
Leukemia Mononuclear | X X X X X X X X X X | 46 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|
| 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
UNTREATD | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + I + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + I + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + I + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + I + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + +|
Leukemia Mononuclear | X|
Sarcoma | X |
__________________________________________________________________________|
Oral Mucosa | + + |
Squamous Cell Carcinoma | X X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tongue | + + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|
| 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
UNTREATD | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X |
Pheochromocytoma Benign, Multiple | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + M + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|
| 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
UNTREATD | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | X X X |
Deep Cervical, Leukemia Mononuclear | X X X X X |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | X X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X |
Pancreatic, Leukemia Mononuclear | X X X X X X X X X|
Renal, Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
Sarcoma | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + M + + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + I + + + + + + + + + + + + +|
Keratoacanthoma | X |
Trichoepithelioma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|
| 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
UNTREATD | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
CONTROL | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X|
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|
DAY ON TEST | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|
| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATD | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + +|
Leukemia Mononuclear | X|
Sarcoma | |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|
DAY ON TEST | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|
| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATD | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X|
Pheochromocytoma Benign, Multiple | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|
DAY ON TEST | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|
| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATD | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | X X X |
Iliac, Leukemia Mononuclear | X X X |
Inguinal, Leukemia Mononuclear | X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X X|
Pancreatic, Leukemia Mononuclear | X X X X X X X X X X|
Renal, Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | |
Sarcoma | X |
__________________________________________________________________________|
Thymus | + + I + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + M + + M +|
Fibroadenoma | X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibroma | X X X |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|
DAY ON TEST | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|
| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATD | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| | |
DAY ON TEST | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| | |
| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
CONTROL | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + | 64 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + + + + + + + + + + + + | 64 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | 65 |
Carcinoma | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 65 |
Leukemia Mononuclear | X | 4 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 66 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | | 2 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 48 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 14 |
Leukemia Mononuclear | X X | 4 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 3 |
Squamous Cell Carcinoma | | 2 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X X X | 9 |
Mesothelioma Malignant | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X X | 6 |
Mesothelioma Malignant | | 1 |
Squamous Cell Papilloma | X X X X | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X X | 7 |
__________________________________________________________________________|____________|
Tongue | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| | |
DAY ON TEST | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| | |
| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
CONTROL | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X X X X | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + | 66 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X | 24 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X | 14 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 8 |
Pheochromocytoma Benign, Multiple | | 1 |
Bilateral, Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 66 |
Adenoma | | 5 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + | 63 |
Leukemia Mononuclear | X X X X | 13 |
Pars Distalis, Adenoma | X | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + | 3 |
Mesothelioma Malignant | X X | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + | 66 |
Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| | |
DAY ON TEST | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| | |
| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
CONTROL | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + | 66 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X | 6 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + | 66 |
Mesothelioma Malignant | X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X | 48 |
Interstitial Cell, Adenoma | X X X | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 66 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X | 38 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 37 |
Leukemia Mononuclear | | 1 |
Axillary, Leukemia Mononuclear | X X | 7 |
Deep Cervical, Leukemia Mononuclear | X X X X | 12 |
Iliac, Leukemia Mononuclear | | 5 |
Inguinal, Leukemia Mononuclear | X | 4 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X X X X | 29 |
Pancreatic, Leukemia Mononuclear | X X X X X X X X | 27 |
Renal, Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | 64 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X | 30 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | 66 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 33 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 46 |
Mesothelioma Malignant | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + I + + + + + + | 61 |
Leukemia Mononuclear | X X X X X X X X | 23 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| | |
DAY ON TEST | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| | |
| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
CONTROL | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + | 61 |
Fibroadenoma | | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 65 |
Keratoacanthoma | X | 2 |
Trichoepithelioma | | 1 |
Subcutaneous Tissue, Fibroma | X | 5 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 66 |
Astrocytoma Malignant | X | 2 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 66 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 29 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 66 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X X X X X | 26 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 66 |
Leukemia Mononuclear | X X X | 4 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| | |
DAY ON TEST | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| | |
| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATD | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
CONTROL | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 48 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|
DAY ON TEST | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|
| 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.2% | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
Sarcoma | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma, Multiple | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
Kupffer Cell, Leukemia Mononuclear | |
__________________________________________________________________________|
Mesentery | + + + + + |
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Mesothelioma Malignant | X X |
Acinar Cell, Adenoma | |
Acinus, Adenoma | |
Acinus, Adenoma, Multiple | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Schwannoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|
DAY ON TEST | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|
| 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.2% | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + M + + + + + + + + M + + M|
Leukemia Mononuclear | X X X X X X X |
Pars Distalis, Adenoma | X X X |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|
DAY ON TEST | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|
| 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.2% | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X X |
Mediastinal, Fibrous Histiocytoma | X |
Mediastinal, Leukemia Mononuclear | X X X X X X X X X X X X|
Pancreatic, Leukemia Mononuclear | X X X X X X X X X X X X X X|
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, Melanoma Benign | |
Subcutaneous Tissue, Melanoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|
DAY ON TEST | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|
| 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1.2% | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Schwannoma Malignant | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
Transitional Epithelium, Carcinoma | |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|
DAY ON TEST | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|
| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Sarcoma | X |
__________________________________________________________________________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma, Multiple | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
Kupffer Cell, Leukemia Mononuclear | X |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrous Histiocytoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Mesothelioma Malignant | X |
Acinar Cell, Adenoma | X |
Acinus, Adenoma | |
Acinus, Adenoma, Multiple | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Schwannoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|
DAY ON TEST | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|
| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X |
Pars Distalis, Adenoma, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X|
Deep Cervical, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|
DAY ON TEST | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|
| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | |
Mediastinal, Fibrous Histiocytoma | |
Mediastinal, Leukemia Mononuclear | X X X X X|
Pancreatic, Leukemia Mononuclear | X X X X X X|
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Carcinoma | |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Lipoma | X |
Subcutaneous Tissue, Melanoma Benign | X |
Subcutaneous Tissue, Melanoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + M + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
_____________________________________________________________________________________________________________________
| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|
DAY ON TEST | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|
| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Schwannoma Malignant | X |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Transitional Epithelium, Carcinoma | X |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| | |
DAY ON TEST | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| | |
| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + + + + M + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 67 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + | 67 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 68 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 49 |
Mesothelioma Malignant | | 1 |
Kupffer Cell, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 14 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | X X X X X X | 14 |
Mesothelioma Malignant | | 3 |
Acinar Cell, Adenoma | | 1 |
Acinus, Adenoma | X | 1 |
Acinus, Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X | 3 |
Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | X X X X | 10 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| | |
DAY ON TEST | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| | |
| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X X X X X X | 16 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X X X X X X X | 21 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X X X X X | 15 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 68 |
Adenoma | X X | 5 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + | 64 |
Leukemia Mononuclear | X X X X | 13 |
Pars Distalis, Adenoma | X | 7 |
Pars Distalis, Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 69 |
C-Cell, Adenoma | X X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 3 |
Mesothelioma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + | 69 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + | 67 |
Leukemia Mononuclear | X | 4 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| | |
DAY ON TEST | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| | |
| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mesothelioma Malignant | | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X | 50 |
Interstitial Cell, Adenoma | X X X | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X X X X X X X X X X | 43 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 39 |
Axillary, Leukemia Mononuclear | X | 4 |
Deep Cervical, Leukemia Mononuclear | X | 3 |
Iliac, Leukemia Mononuclear | X X | 5 |
Inguinal, Leukemia Mononuclear | X X | 4 |
Mediastinal, Fibrous Histiocytoma | | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X | 22 |
Pancreatic, Leukemia Mononuclear | X X X X X X X X X | 29 |
Renal, Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | X X X X X | 28 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | X X X X X X X X | 32 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X | 51 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + + + M + + + + + + | 63 |
Leukemia Mononuclear | X X X X X | 16 |
Thymoma Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + | 68 |
Carcinoma | X | 1 |
Fibroadenoma | X X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + I + + + M + + + + + + + | 67 |
Keratoacanthoma | | 2 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Lipoma | | 1 |
Subcutaneous Tissue, Melanoma Benign | X | 2 |
Subcutaneous Tissue, Melanoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05094-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 03/17/97
Route: DOSED FEED Time: 12:46:10
__________________________________________________________________________________________________________________________________
| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| | |
DAY ON TEST | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| | |
| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 68 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 69 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X | 31 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 68 |
Leukemia Mononuclear | X X X X X X X | 25 |
__________________________________________________________________________|____________|
Urethra | + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X X | 5 |
Mesothelioma Malignant | | 1 |
Transitional Epithelium, Carcinoma | | 1 |
Transitional Epithelium, Papilloma | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + | 69 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X | 51 |
Mesothelioma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
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---------- END OF REPORT ----------
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