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TDMS Study 05094-03 Pathology Tables

NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97
Route: DOSED FEED                                                                                                 Time: 12:46:10

                                                          CORE ANIMALS




       Facility:  Southern Research Institute

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25004 Dead
                               25003 Moribund                          25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|             
                             DAY ON TEST   | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|             
                                           | 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    CONTROL                                | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |    X  X        X        X  X     X  X  X  X  X           X  X  X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                   +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                   X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X        X  X  X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                    X        X  X  X  X  X              X           X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X        X     X  X                             X|             
      Pheochromocytoma Malignant           |          X                                                               |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                          X     X  X  X                          X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|             
                             DAY ON TEST   | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|             
                                           | 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    CONTROL                                | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               | X           X     X                             X     X  X        X      |             
      Pars Distalis, Adenoma, Multiple     |                                                                X         |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |    X              X                                                      |             
      C-Cell, Carcinoma                    |                                                                         X|             
      Follicular Cell, Adenoma             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +                                                   |             
      Sarcoma                              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                X     X            |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                   X                                                      |             
      Leukemia Mononuclear                 |    X                    X        X     X  X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Polyp Stromal                        |                                                                          |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |             +                                M                       +   |             
      Squamous Cell Papilloma              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X           X     X  X  X  X  X              X           X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +        +        +        +  +  +  +  +              +           +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |    X                                                                     |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X           X                    X  X     X                          X|             
      Pancreatic, Leukemia Mononuclear     |    X  X                 X        X     X  X                 X            |             
      Popliteal, Leukemia Mononuclear      |                                                                          |             
      Renal, Leukemia Mononuclear          |    X                             X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X        X        X  X  X  X  X              X  X        X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|             
                             DAY ON TEST   | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|             
                                           | 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    CONTROL                                | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X  X        X        X           X  X  X  X              X  X        X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                     +                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X        X  X     X  X  X  X  X              X  X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X                          X  X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                             X                        |             
      Fibroadenoma                         |                                              X              X  X  X  X   |             
      Fibroadenoma, Multiple               |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Papilloma              |                                                                X         |             
      Sebaceous Gland, Basal Cell Adenoma  |                                                                   X      |             
      Subcutaneous Tissue, Fibroma         |                                                    X                    X|             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                | X                                                                        |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Ependymoma Malignant                 |                                                                          |             
      Glioma Malignant                     |                                                             X            |             
      Leukemia Mononuclear                 |    X                    X        X  X  X                                 |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                  +                                       |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                  +                                       |             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |    X           X        X        X  X  X  X  X                          X|             
      Sarcoma, Metastatic, Tissue NOS      |                      X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 6| 6| 7| 7| 6| 5| 6| 3| 5| 3| 6| 6| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9|             
                             DAY ON TEST   | 6| 8| 8| 2| 7| 0| 1| 7| 9| 1| 2| 5| 5| 2| 8| 4| 9| 8| 0| 7| 4| 7| 1| 7| 6|             
                                           | 4| 7| 7| 4| 4| 5| 2| 7| 7| 6| 4| 1| 9| 5| 4| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    CONTROL                                | 3| 5| 9| 1| 3| 5| 2| 4| 7| 0| 9| 1| 2| 3| 6| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                   +            |             
      Carcinoma                            |                         X                                   X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                    X        X  X  X  X  X                          X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Transitional Epithelium, Papilloma   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X        X  X     X  X  X  X  X           X  X  X        X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|             
                             DAY ON TEST   | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|             
                                           | 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                           X                              |             
      Leukemia Mononuclear                 | X  X           X           X  X  X  X  X  X           X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                 +           +  +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                   X                          X  X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X     X                    X         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X           X                    X         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                         X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X                       X  X     X                 X     X  X  X      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Leukemia Mononuclear                 | X                          X  X        X                       X         |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X  X                                X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   6                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|             
                             DAY ON TEST   | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|             
                                           | 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |    X     X  X     X                          X     X     X     X     X  X|             
      Pars Distalis, Adenoma, Multiple     |                                     X                                    |             
      Pars Distalis, Carcinoma             |                                                             X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
      C-Cell, Adenoma                      |    X                                      X     X           X            |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                                |             
      Carcinoma                            |          X        X                 X                                    |             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |                               X                                X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X  X                                X         |             
      Polyp Stromal                        |                      X                    X     X                        |             
      Polyp Stromal, Multiple              |                                                                          |             
      Sarcoma Stromal                      |                      X                                                   |             
                                            __________________________________________________________________________|             
   Vagina                                  |    M        M              M              M     M  M     M     M         |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X           X           X  X  X  X  X              X     X  X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +                 +  +  +  +     +     +                 +  +  +      |             
      Axillary, Leukemia Mononuclear       |                            X  X     X                          X         |             
      Deep Cervical, Leukemia Mononuclear  |                            X  X                                          |             
      Iliac, Leukemia Mononuclear          | X                          X  X     X     X                    X         |             
      Inguinal, Leukemia Mononuclear       |                               X     X                                    |             
      Mediastinal, Leukemia Mononuclear    |                            X  X     X     X                 X  X  X      |             
      Pancreatic, Leukemia Mononuclear     | X  X                       X  X     X                          X  X      |             
      Popliteal, Leukemia Mononuclear      |                            X                                             |             
      Renal, Leukemia Mononuclear          | X                             X     X     X                    X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                          X  X  X  X  X  X                 X  X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   7                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|             
                             DAY ON TEST   | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|             
                                           | 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 | X                          X  X     X     X                 X  X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                               +                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X           X           X  X  X  X  X  X           X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                          X  X     X                          X  X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                          X               |             
      Fibroadenoma                         |       X  X  X  X                    X           X     X        X        X|             
      Fibroadenoma, Multiple               |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                           X              X               |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Basal Cell Adenoma  |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                  X                                       |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                             X            |             
      Ependymoma Malignant                 |                                                 X                        |             
      Glioma Malignant                     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Leukemia Mononuclear                 | X  X                          X        X              X     X  X  X      |             
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   8                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9|             
                             DAY ON TEST   | 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7| 5| 2| 1| 4| 1| 9| 2| 8| 9| 7|             
                                           | 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                          X           X           X     X  X  X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X           X           X  X  X  X  X  X           X     X  X  X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   9                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|                             |            |
                             DAY ON TEST   | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|                             |            |
                                           | 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                             |     A      |
    UNTREATD                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |     L      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                              |  63        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                              |  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  63        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Leukemia Mononuclear                 |    X     X  X  X     X     X  X  X  X     X                              |         38 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  62        |
      Leukemia Mononuclear                 |             X                    X                                       |          8 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Leukemia Mononuclear                 |                                  X                                       |          6 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                              |  62        |
      Leukemia Mononuclear                 |                                  X                                       |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                              |  63        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                         +                                                |   1        |
      Squamous Cell Papilloma              |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X                             X                                       |          8 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X     X     X              X  X                                       |         23 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  63        |
      Leukemia Mononuclear                 |             X              X                                             |         13 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              | X                                         X                              |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|                             |            |
                             DAY ON TEST   | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|                             |            |
                                           | 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                             |     A      |
    UNTREATD                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |     L      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  62        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +                              |  63        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X                 X        X                                          |         13 |
      Pars Distalis, Adenoma               | X  X        X     X     X  X  X        X  X                              |         26 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          2 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          6 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Adenoma                              |                   X              X                                       |          6 |
      Carcinoma                            |                               X        X                                 |          5 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Leukemia Mononuclear                 |                      X                                                   |          8 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |                                  X                                       |          5 |
      Polyp Stromal                        |                                                                          |          3 |
      Polyp Stromal, Multiple              |                                        X                                 |          1 |
      Sarcoma Stromal                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |          M                                                               |   2        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X     X  X  X     X     X  X  X                                       |         31 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +     +     +     +  +  +                                       |  29        |
      Axillary, Leukemia Mononuclear       |                               X  X                                       |          6 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|                             |            |
                             DAY ON TEST   | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|                             |            |
                                           | 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                             |     A      |
    UNTREATD                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |     L      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Deep Cervical, Leukemia Mononuclear  |                      X     X                                             |          4 |
      Iliac, Leukemia Mononuclear          |                            X     X                                       |          9 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear    |    X           X     X     X  X  X                                       |         19 |
      Pancreatic, Leukemia Mononuclear     |    X     X           X     X  X  X                                       |         20 |
      Popliteal, Leukemia Mononuclear      |                                  X                                       |          2 |
      Renal, Leukemia Mononuclear          |                      X     X     X                                       |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Leukemia Mononuclear                 |    X     X           X     X  X  X                                       |         28 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X     X  X        X     X  X  X                                       |         26 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X     X  X  X     X     X  X  X        X                              |         36 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                              |  64        |
      Leukemia Mononuclear                 |                      X     X     X                                       |         13 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  64        |
      Carcinoma                            | X                 X                                                      |          5 |
      Fibroadenoma                         |       X           X              X        X                              |         18 |
      Fibroadenoma, Multiple               |                                     X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Sebaceous Gland, Basal Cell Adenoma  |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |       X                                                                  |          1 |
      Subcutaneous Tissue, Melanoma        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Osteosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Astrocytoma Malignant                |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|                             |            |
                             DAY ON TEST   | 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|                             |            |
                                           | 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|                             |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                             |     A      |
    UNTREATD                               | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                             |     L      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Ependymoma Malignant                 |                                                                          |          1 |
      Glioma Malignant                     |                                                                          |          1 |
      Leukemia Mononuclear                 |    X           X                                                         |          7 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |    +                          +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                          +                                          |   3        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |    X     X  X  X           X  X  X                                       |         24 |
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X           X     X     X                                             |         19 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                              |  64        |
      Leukemia Mononuclear                 |                                  X                                       |          2 |
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  65        |
      Leukemia Mononuclear                 |    X     X  X  X     X     X  X  X  X     X                              |         38 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|             
                             DAY ON TEST   | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|             
                                           | 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                        X                                X|             
      Leukemia Mononuclear                 |       X  X  X  X     X  X  X     X           X  X  X  X        X  X  X  X|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Lipoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                            X                  |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                 +            |             
      Odontoma                             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                    X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X        X  X        X                    X        X         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X           X  X        X                             X        X|             
      Pheochromocytoma Benign              |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|             
                             DAY ON TEST   | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|             
                                           | 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                         X         |             
      Pars Distalis, Adenoma               | X  X                                   X     X  X                 X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                  X        X              X               |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X                    X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                         X              X        X                    X   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X     X  X        X              X     X        X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +  +  +        +                                   +   |             
      Axillary, Leukemia Mononuclear       |                      X                                                   |             
      Deep Cervical, Leukemia Mononuclear  |                      X                                                   |             
      Iliac, Leukemia Mononuclear          |                      X                                                   |             
      Inguinal, Leukemia Mononuclear       |                      X                                                   |             
      Mediastinal, Leukemia Mononuclear    |                      X  X        X                                       |             
      Pancreatic, Leukemia Mononuclear     |       X  X           X  X        X                                   X   |             
      Renal, Leukemia Mononuclear          |          X           X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X        X  X        X              X  X  X        X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X     X     X  X        X                    X        X        X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                   +                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X     X  X  X     X           X  X  X  X        X  X  X  X|             
      Mesothelioma NOS                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |          X           X                                X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  15                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|             
                             DAY ON TEST   | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|             
                                           | 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                 X                        |             
      Fibroadenoma                         | X                                   X        X                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |                      X                                X                  |             
      Oligodendroglioma Malignant          |                               X                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |       X  X     X     X           X                    X        X        X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
      Carcinoma                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X           X              X     X        X     X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Transitional Epithelium, Carcinoma   |                                                 X                        |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X     X  X  X     X           X  X  X  X        X  X  X  X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  16                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 7| 6| 7| 4| 6| 6| 5| 4| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6|             
                             DAY ON TEST   | 0| 5| 7| 1| 6| 0| 2| 5| 8| 9| 9| 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9|             
                                           | 0| 2| 7| 5| 7| 5| 8| 2| 3| 2| 8| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 7| 7| 8| 8| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 3| 9| 6| 8| 0| 9| 3| 4| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Mesothelioma NOS                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  17                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|             
                             DAY ON TEST   | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|             
                                           | 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |          X                                                               |             
      Hepatocellular Adenoma               |                   X                                                      |             
      Leukemia Mononuclear                 | X  X  X     X  X           X  X     X  X     X        X  X     X  X  X  X|             
      Mesothelioma NOS                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +        +                          +        +      |             
      Leukemia Mononuclear                 |                               X                          X               |             
      Lipoma                               |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X        X                 X        X  X   |             
      Acinus, Adenoma                      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                     X           X   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
      Odontoma                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X           X                             X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X        X           X  X     X  X     X        X  X        X     X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X     X  X           X                             X               |             
      Pheochromocytoma Benign              |       X        X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  18                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|             
                             DAY ON TEST   | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|             
                                           | 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                             X               |             
      Pars Distalis, Adenoma               |          X        X  X  X        X  X     X        X                    X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                           X  X                           |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                     X               |             
      Polyp Stromal                        |                                        X                             X   |             
                                            __________________________________________________________________________|             
   Vagina                                  |       M        M                 M                                   M   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X        X           X  X     X  X              X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +                    +  +        +              +  +     +  +  +   |             
      Axillary, Leukemia Mononuclear       |                               X                                   X      |             
      Deep Cervical, Leukemia Mononuclear  |                                                                   X      |             
      Iliac, Leukemia Mononuclear          |                                                          X        X      |             
      Inguinal, Leukemia Mononuclear       |                                                                   X      |             
      Mediastinal, Leukemia Mononuclear    |    X  X                       X        X                          X  X   |             
      Pancreatic, Leukemia Mononuclear     | X  X  X                    X  X        X              X  X        X      |             
      Renal, Leukemia Mononuclear          |    X  X                       X                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X        X           X  X     X  X     X        X  X     X  X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X                       X     X  X     X        X  X        X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X  X  X  X     X  X     X        X  X     X  X  X  X|             
      Mesothelioma NOS                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                   X                          X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|             
                             DAY ON TEST   | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|             
                                           | 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |       X                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                   X                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                             X            |             
      Carcinoma, Metastatic, Zymbal's Gland|                         X                                                |             
      Leukemia Mononuclear                 |                            X                                             |             
      Oligodendroglioma Malignant          |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |             
      Carcinoma, Metastatic, Zymbal's Gland|                         X                                                |             
      Leukemia Mononuclear                 |    X           X           X  X                       X  X     X  X     X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
      Carcinoma                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X        X  X           X  X        X              X  X        X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
      Transitional Epithelium, Papilloma   | X           X                                                            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X  X  X  X     X  X     X        X  X     X  X  X  X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9|             
                             DAY ON TEST   | 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4| 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7|             
                                           | 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Mesothelioma NOS                     |             X                                                            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|                                         |            |
                             DAY ON TEST   | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|                                         |            |
                                           | 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|                                         |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                         |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     A      |
    2.4%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                         |     L      |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +                                          |  60        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Hepatocellular Carcinoma             |                            X                                             |          2 |
      Hepatocellular Adenoma               |                                                                          |          3 |
      Leukemia Mononuclear                 |    X  X  X  X  X  X  X  X  X  X                                          |         42 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Lipoma                               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X                    X                                                |          9 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Odontoma                             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |                         X                                                |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X              X  X  X                                                |         23 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  22                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|                                         |            |
                             DAY ON TEST   | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|                                         |            |
                                           | 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|                                         |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                         |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     A      |
    2.4%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                         |     L      |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                      X  X                                                |         16 |
      Pheochromocytoma Benign              |                X  X                                                      |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +                                          |  60        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +                                          |  60        |
      Leukemia Mononuclear                 |    X  X                                                                  |          6 |
      Pars Distalis, Adenoma               | X           X              X                                             |         18 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      Follicular Cell, Carcinoma           | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +                                          |  60        |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X  X                                                                  |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
      Polyp Stromal                        |       X              X                                                   |          8 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                            M                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X  X  X        X     X     X                                          |         31 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +        +           +                                          |  23        |
      Axillary, Leukemia Mononuclear       |                                                                          |          3 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |    X  X                                                                  |          5 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear    |    X  X           X                                                      |         12 |
      Pancreatic, Leukemia Mononuclear     |       X  X        X           X                                          |         19 |
      Renal, Leukemia Mononuclear          |    X  X                       X                                          |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |       X     X           X     X                                          |         28 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|                                         |            |
                             DAY ON TEST   | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|                                         |            |
                                           | 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|                                         |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                         |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     A      |
    2.4%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                         |     L      |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X  X                 X     X                                          |         24 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X  X  X  X  X  X  X  X  X  X                                          |         46 |
      Mesothelioma NOS                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +                                          |  57        |
      Leukemia Mononuclear                 |    X  X                                                                  |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Carcinoma                            |                                                                          |          1 |
      Fibroadenoma                         |             X        X                                                   |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Keratoacanthoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   1        |
      Rhabdomyosarcoma                     |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +                                          |  60        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |          4 |
      Oligodendroglioma Malignant          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X           X     X                                                |         21 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  24                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|                                         |            |
                             DAY ON TEST   | 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|                                         |            |
                                           | 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|                                         |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                         |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                         |     A      |
    2.4%                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                         |     L      |
                                           | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                         |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X  X                 X     X                                          |         21 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Transitional Epithelium, Carcinoma   | X              X  X                                                      |          4 |
      Transitional Epithelium, Papilloma   |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +                                          |  61        |
      Leukemia Mononuclear                 |    X  X  X  X  X  X  X  X  X  X                                          |         46 |
      Mesothelioma NOS                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  25                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|             
                                           | 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    UNTREATD                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Mesothelioma Malignant               |                         X                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                    X                     |             
      Hepatocellular Adenoma               |                                           X                          X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X  X  X        X  X           X  X     X  X        X  X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +              +  +              +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Sarcoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                     +                    +               |             
      Squamous Cell Carcinoma              |                                     X                    X               |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                       X              X   |             
      Mesothelioma Malignant               |                         X                                                |             
      Sarcoma, Metastatic, Mesentery       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X              X                           |             
      Mesothelioma Malignant               |                         X                                                |             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                        +               |             
      Squamous Cell Carcinoma              | X                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  26                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|             
                                           | 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    UNTREATD                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |          X  X              X                                      X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                X        X                 X|             
      Pheochromocytoma Malignant           |                                              X                           |             
      Pheochromocytoma Benign              |                   X                    X                                 |             
      Pheochromocytoma Benign, Multiple    |                                                    X                     |             
      Bilateral, Pheochromocytoma Benign   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |       X                             X                                    |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X           X                 X                 X        X|             
      Pars Distalis, Adenoma               |    X                                                  X  X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      C-Cell, Adenoma                      | X        X                          X        X           X  X        X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                         +                                                |             
      Mesothelioma Malignant               |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                         X                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                      X   |             
      Mesothelioma Malignant               |                         X                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                         X                                                |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X     X  X  X           X  X     X        X     X  X  X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|             
                                           | 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    UNTREATD                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |             X                       X                 X  X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X  X  X  X        X  X           X  X        X        X  X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +  +     +  +  +        +  +           +        +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Axillary, Leukemia Mononuclear       |             X                 X                                X         |             
      Deep Cervical, Leukemia Mononuclear  |             X                 X           X                    X     X   |             
      Iliac, Leukemia Mononuclear          |                               X                                X         |             
      Inguinal, Leukemia Mononuclear       |                               X                                X         |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X  X  X  X           X           X                    X  X  X   |             
      Pancreatic, Leukemia Mononuclear     |          X  X  X           X  X           X                    X     X  X|             
      Renal, Leukemia Mononuclear          |                               X                                X  X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X  X  X              X           X  X        X        X  X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |          X  X  X           X  X           X           X        X  X  X  X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X  X        X  X           X  X     X  X        X  X  X  X|             
      Mesothelioma Malignant               |                         X                                                |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X              X        X        X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                          X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                          X               |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 6| 6| 6| 4| 6| 6| 5| 5| 7| 4| 6| 7| 8| 8| 6| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 4| 8| 2| 0| 5| 4| 9| 3| 0| 8| 8| 0| 1| 6| 4| 2| 9| 9| 1| 6| 0| 1| 4| 1| 7|             
                                           | 9| 1| 9| 9| 5| 5| 6| 2| 0| 2| 3| 7| 9| 7| 5| 3| 3| 7| 7| 8| 1| 9| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    UNTREATD                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    CONTROL                                | 1| 4| 5| 0| 1| 4| 5| 6| 8| 0| 6| 9| 2| 4| 3| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                     +                                    |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                    X                     |             
      Leukemia Mononuclear                 |          X  X  X  X        X  X           X  X                 X  X     X|             
      Sarcoma, Metastatic, Mesentery       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
      Carcinoma                            |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X           X  X           X                    X  X  X  X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X  X  X        X  X           X  X     X  X        X  X  X  X|             
      Mesothelioma Malignant               |                         X                                                |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|             
                             DAY ON TEST   | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|             
                                           | 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                      X   |             
      Leukemia Mononuclear                 |                      X                          X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X     X     X  X  X  X  X  X  X        X  X  X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                         +     +              +        +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|             
                             DAY ON TEST   | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|             
                                           | 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                      X           X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
      Leukemia Mononuclear                 |          X           X  X        X  X  X              X        X  X     X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X        X  X           X           X  X         |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                X              X                                   X     X|             
      Pheochromocytoma Benign, Multiple    |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X        X     X                              |             
      Carcinoma                            |    X              X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                       X     X                  |             
      Pars Distalis, Adenoma               | X                 X        X     X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                    X                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                          X               |             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X           X  X  X     X  X     X  X  X  X  X  X     X|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  31                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|             
                             DAY ON TEST   | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|             
                                           | 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Adenoma           |                      X  X  X                                         X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X     X  X           X  X        X  X           X     X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +     +  +     +  +  +  +        +     +     +  +  +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Axillary, Leukemia Mononuclear       |                      X                          X                        |             
      Deep Cervical, Leukemia Mononuclear  |                                     X           X           X            |             
      Iliac, Leukemia Mononuclear          |                      X              X           X                        |             
      Inguinal, Leukemia Mononuclear       |                                                 X                        |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                      X  X     X  X  X  X        X     X     X  X  X     X|             
      Pancreatic, Leukemia Mononuclear     |                      X  X        X  X           X     X     X  X  X     X|             
      Renal, Leukemia Mononuclear          |                X     X              X           X                       X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X                    X     X     X  X           X     X     X  X  X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X        X     X     X  X        X  X           X           X  X        X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X     X     X  X  X  X  X  X  X        X  X  X     X  X  X      |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma                              |                                           X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                      X           X              X     X     X  X        X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +|             
      Fibroadenoma                         |          X                                                              X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Trichoepithelioma                    | X                                                                        |             
      Subcutaneous Tissue, Fibroma         |    X        X           X                                                |             
      Subcutaneous Tissue, Fibrosarcoma    |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  32                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8| 5| 8| 6| 8| 6| 6| 8| 5| 7|             
                             DAY ON TEST   | 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9| 6| 9| 5| 9| 1| 9| 2| 1| 9|             
                                           | 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7| 9| 7| 6| 7| 7| 8| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                      X  X        X  X  X        X     X     X  X  X     X|             
      Sarcoma, Metastatic, Mesentery       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
      Carcinoma                            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X  X        X  X           X     X     X  X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X     X     X  X  X  X  X  X  X        X  X  X     X  X  X     X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  33                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|                          |            |
                             DAY ON TEST   | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|                          |            |
                                           | 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                          |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                          |     L      |
    CONTROL                                | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                           |  64        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  64        |
      Leukemia Mononuclear                 |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 |                                  X                                       |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Carcinoma                            |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Leukemia Mononuclear                 |                                  X                                       |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Hepatocellular Carcinoma             | X                                                                        |          2 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Histiocytic Sarcoma                  |                   X                                                      |          1 |
      Leukemia Mononuclear                 | X  X  X  X  X  X     X  X  X     X  X  X  X  X                           |         48 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                    +  +                                       |  14        |
      Leukemia Mononuclear                 |          X                       X                                       |          4 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                  +                                       |   3        |
      Squamous Cell Carcinoma              |                                                                          |          2 |
      Squamous Cell Papilloma              |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X              X                 X  X  X                                 |          9 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X              X                 X     X                                 |          6 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Squamous Cell Papilloma              | X           X           X        X                                       |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X                    X           X     X                                 |          7 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|                          |            |
                             DAY ON TEST   | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|                          |            |
                                           | 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                          |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                          |     L      |
    CONTROL                                | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X        X     X                 X     X     X                           |         11 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X  X     X     X           X  X     X  X                           |         24 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X                    X  X                                                |         14 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |                            X           X                                 |          8 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Adenoma                              |                                                                          |          5 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                           |  64        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  63        |
      Leukemia Mononuclear                 | X              X     X                 X                                 |         13 |
      Pars Distalis, Adenoma               |                               X                                          |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                                                          |          8 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                +                 +                                       |   3        |
      Mesothelioma Malignant               |                X                 X                                       |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 |                                  X                                       |          1 |
      Mesothelioma Malignant               |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Carcinoma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  35                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|                          |            |
                             DAY ON TEST   | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|                          |            |
                                           | 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                          |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                          |     L      |
    CONTROL                                | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X                                      X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                X                                       |          4 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X                                X     X                                 |          6 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Mesothelioma Malignant               |                X                                                         |          2 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X     X  X  X  X                              |         48 |
      Interstitial Cell, Adenoma           |             X                 X              X                           |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Histiocytic Sarcoma                  |                   X                                                      |          1 |
      Leukemia Mononuclear                 | X  X  X  X     X     X  X        X  X  X  X  X                           |         38 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +              +  +  +  +  +                           |  37        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Axillary, Leukemia Mononuclear       | X                                            X                           |          7 |
      Deep Cervical, Leukemia Mononuclear  | X        X     X                             X                           |         12 |
      Iliac, Leukemia Mononuclear          |                                                                          |          5 |
      Inguinal, Leukemia Mononuclear       |          X                                                               |          4 |
      Mediastinal, Histiocytic Sarcoma     |                   X                                                      |          1 |
      Mediastinal, Leukemia Mononuclear    | X  X     X     X                 X  X     X  X                           |         29 |
      Pancreatic, Leukemia Mononuclear     | X  X     X     X                    X  X  X  X                           |         27 |
      Renal, Leukemia Mononuclear          | X              X                                                         |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  64        |
      Histiocytic Sarcoma                  |                   X                                                      |          1 |
      Leukemia Mononuclear                 | X  X     X     X                 X  X  X     X                           |         30 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Histiocytic Sarcoma                  |                   X                                                      |          1 |
      Leukemia Mononuclear                 | X  X     X     X     X  X        X  X  X  X  X                           |         33 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X  X  X  X  X  X     X  X  X     X  X  X  X  X                           |         46 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +                           |  61        |
      Leukemia Mononuclear                 | X  X     X     X                 X  X  X     X                           |         23 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  36                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|                          |            |
                             DAY ON TEST   | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|                          |            |
                                           | 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                          |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                          |     L      |
    CONTROL                                | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  61        |
      Fibroadenoma                         |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  65        |
      Keratoacanthoma                      |             X                                                            |          2 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                X                                                         |          5 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Astrocytoma Malignant                |                                              X                           |          2 |
      Leukemia Mononuclear                 |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X              X        X  X  X     X                           |         29 |
      Sarcoma, Metastatic, Mesentery       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X  X     X     X                 X  X     X                              |         26 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
      Leukemia Mononuclear                 | X              X                       X                                 |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                           |  66        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  37                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|                          |            |
                             DAY ON TEST   | 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|                          |            |
                                           | 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|                          |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                          |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                          |     L      |
    CONTROL                                | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                          |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                   X                                                      |          1 |
      Leukemia Mononuclear                 | X  X  X  X  X  X     X  X  X     X  X  X  X  X                           |         48 |
      Mesothelioma Malignant               |                X                 X                                       |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  38                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|             
                             DAY ON TEST   | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|             
                                           | 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.2%                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X        X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X        X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                       X        X            |             
      Mesothelioma Malignant               |                                     X                                    |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma, Multiple     |                               X                                          |             
      Leukemia Mononuclear                 | X  X     X        X  X  X  X  X  X     X  X  X  X  X  X     X     X     X|             
      Mesothelioma Malignant               |                                     X                                    |             
      Kupffer Cell, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +  +     +     +                       +                     |             
      Fibrous Histiocytoma                 |                X                                                         |             
      Leukemia Mononuclear                 |                            X                       X                     |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                 X                       X  X     X           X|             
      Mesothelioma Malignant               |                                     X                                X   |             
      Acinar Cell, Adenoma                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Adenoma, Multiple            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                X            |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X     X            |             
      Mesothelioma Malignant               |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X        X           X  X           X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|             
                             DAY ON TEST   | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|             
                                           | 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.2%                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X                    X  X     X     X                 X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X        X                       X     X                       X|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M|             
      Leukemia Mononuclear                 |    X     X        X                    X  X     X     X                  |             
      Pars Distalis, Adenoma               |       X     X                                      X                     |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                     +                                +   |             
      Mesothelioma Malignant               |                                     X                                X   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Mesothelioma Malignant               |                                                                      X   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                          X     X            |             
      Mesothelioma Malignant               |                                                                      X   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                      X   |             
      Bilateral, Interstitial Cell, Adenoma| X        X     X     X  X  X  X  X  X     X  X     X     X        X  X  X|             
      Interstitial Cell, Adenoma           |    X              X                    X        X     X        X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X  X  X  X  X  X     X  X  X  X  X  X     X           X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +     +  +  +  +  +  +  +     +  +  +  +  +  +     +           +|             
      Axillary, Leukemia Mononuclear       |    X                                                        X            |             
      Deep Cervical, Leukemia Mononuclear  |                            X                                X            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  40                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|             
                             DAY ON TEST   | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|             
                                           | 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.2%                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                             X            |             
      Inguinal, Leukemia Mononuclear       |                            X                                X            |             
      Mediastinal, Fibrous Histiocytoma    |                X                                                         |             
      Mediastinal, Leukemia Mononuclear    | X  X     X        X  X  X     X  X           X     X  X                 X|             
      Pancreatic, Leukemia Mononuclear     | X        X        X  X     X  X  X     X  X     X  X  X     X           X|             
      Renal, Leukemia Mononuclear          |                                                    X        X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X  X  X  X     X        X  X     X  X     X           X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X  X  X  X     X     X  X  X     X  X     X           X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X  X  X  X  X  X     X  X  X  X  X  X     X     X     X|             
      Mesothelioma Malignant               |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X  X  X           X           X  X     X           X|             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                X         |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue, Melanoma Benign |                                                                          |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Fibrous Histiocytoma                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                 X                        |             
      Leukemia Mononuclear                 |                         X                 X     X                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 3| 6| 6| 5| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 6| 8| 5| 5| 8| 6| 6|             
                             DAY ON TEST   | 7| 1| 6| 0| 5| 1| 8| 8| 3| 7| 9| 1| 1| 2| 6| 3| 1| 0| 1| 9| 7| 2| 9| 6| 7|             
                                           | 7| 9| 3| 5| 0| 0| 4| 9| 4| 4| 8| 9| 5| 8| 7| 0| 6| 9| 9| 7| 9| 1| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1.2%                                   | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
                                           | 5| 7| 0| 1| 3| 4| 6| 8| 9| 0| 1| 3| 2| 3| 8| 1| 6| 8| 9| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 | X  X     X        X  X  X  X  X  X     X  X  X  X  X  X     X           X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X        X  X  X  X  X        X  X     X  X  X     X            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X              X                                 |             
      Mesothelioma Malignant               |                                     X                                    |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
      Transitional Epithelium, Papilloma   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X        X  X  X  X  X  X     X  X  X  X  X  X     X     X     X|             
      Mesothelioma Malignant               |                                     X                                X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|             
                             DAY ON TEST   | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|             
                                           | 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Leukemia Mononuclear                 | X  X     X     X  X  X        X     X  X  X  X     X  X  X  X     X     X|             
      Mesothelioma Malignant               |                                                                          |             
      Kupffer Cell, Leukemia Mononuclear   |                            X                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +  +  +                                                   |             
      Fibrous Histiocytoma                 |                                                                          |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
      Mesothelioma Malignant               |                                                                      X   |             
      Acinar Cell, Adenoma                 |                                  X                                       |             
      Acinus, Adenoma                      |                                                                          |             
      Acinus, Adenoma, Multiple            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Schwannoma Malignant                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                   X                 X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X  X              X                 X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|             
                             DAY ON TEST   | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|             
                                           | 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X     X                       X              X                 X|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                             X  X                             X|             
      Pheochromocytoma Malignant           |                                                    X                     |             
      Pheochromocytoma Benign              |                                  X              X  X                 X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                             X        X                                 |             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                        X              X                  |             
      Pars Distalis, Adenoma               | X                                               X                 X      |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                      +   |             
      Mesothelioma Malignant               |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                      X   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                       X         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Mesothelioma Malignant               |                                                                      X   |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X     X  X  X  X  X  X     X  X  X     X  X  X  X|             
      Interstitial Cell, Adenoma           |             X              X                    X                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X  X  X        X     X  X  X  X     X  X  X  X     X     X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +        +  +     +  +        +     +     +  +     +        +  +|             
      Axillary, Leukemia Mononuclear       |                                                                         X|             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|             
                             DAY ON TEST   | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|             
                                           | 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                        X              X                  |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Fibrous Histiocytoma    |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                      X        X                    X  X                 X|             
      Pancreatic, Leukemia Mononuclear     |          X        X                          X     X  X                 X|             
      Renal, Leukemia Mononuclear          |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X  X        X        X  X        X  X           X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X              X        X  X  X     X  X           X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X     X  X  X     X  X     X  X  X  X     X  X  X  X     X     X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                     X                                    |             
      Subcutaneous Tissue, Fibroma         |                         X                                      X         |             
      Subcutaneous Tissue, Lipoma          |                   X                                                      |             
      Subcutaneous Tissue, Melanoma Benign |                                              X                           |             
      Subcutaneous Tissue, Melanoma        |                                                                          |             
          Malignant                        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrous Histiocytoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                         +  +                                             |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +  +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                            X                                             |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6| 7| 4| 8| 8| 8| 6|             
                             DAY ON TEST   | 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3| 2| 9| 4| 9| 0| 4|             
                                           | 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3| 3| 9| 4| 7| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|             
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                 X                        |             
      Leukemia Mononuclear                 |                X  X                    X  X        X  X  X  X           X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Schwannoma Malignant                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
      Carcinoma                            |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                       X              X  X              X|             
                                            __________________________________________________________________________|             
   Urethra                                 |                            +                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Transitional Epithelium, Carcinoma   |                            X                                             |             
      Transitional Epithelium, Papilloma   |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X     X  X  X     X  X     X  X  X  X     X  X  X  X     X     X|             
      Mesothelioma Malignant               |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  46                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|                 |            |
                             DAY ON TEST   | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|                 |            |
                                           | 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                 |     A      |
    1.2%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                 |     L      |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +                  |  67        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X     X  X  X     X     X  X  X  X        X  X  X  X                  |         49 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Kupffer Cell, Leukemia Mononuclear   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                          +     +     +  +                        |  14        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                 X                        |          4 |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                     +                                    |   1        |
      Squamous Cell Papilloma              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 |    X     X  X  X                 X              X                        |         14 |
      Mesothelioma Malignant               |                                                                          |          3 |
      Acinar Cell, Adenoma                 |                                                                          |          1 |
      Acinus, Adenoma                      |                                     X                                    |          1 |
      Acinus, Adenoma, Multiple            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 |                X                                                         |          3 |
      Schwannoma Malignant                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 |    X           X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 |    X     X  X  X                                                         |         10 |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|                 |            |
                             DAY ON TEST   | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|                 |            |
                                           | 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                 |     A      |
    1.2%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                 |     L      |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 |    X     X  X  X                 X              X                        |         16 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 | X  X        X        X     X     X                    X                  |         21 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 |    X     X  X              X                    X                        |         15 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              | X                             X                                          |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Adenoma                              |                         X                          X                     |          5 |
      Carcinoma                            |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                  |  67        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  64        |
      Leukemia Mononuclear                 |    X        X                    X                    X                  |         13 |
      Pars Distalis, Adenoma               |                                     X                                    |          7 |
      Pars Distalis, Adenoma, Multiple     | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      C-Cell, Adenoma                      |                      X        X        X                                 |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
      Mesothelioma Malignant               |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  67        |
      Leukemia Mononuclear                 |    X                                                                     |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|                 |            |
                             DAY ON TEST   | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|                 |            |
                                           | 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                 |     A      |
    1.2%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                 |     L      |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma| X     X  X     X        X  X  X  X  X        X  X  X  X                  |         50 |
      Interstitial Cell, Adenoma           |    X        X        X                                                   |         12 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 | X  X     X  X  X     X     X     X              X     X                  |         43 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +  +     +     +     +              +     +                  |  39        |
      Axillary, Leukemia Mononuclear       |             X                                                            |          4 |
      Deep Cervical, Leukemia Mononuclear  |             X                                                            |          3 |
      Iliac, Leukemia Mononuclear          |             X                                   X                        |          5 |
      Inguinal, Leukemia Mononuclear       |    X        X                                                            |          4 |
      Mediastinal, Fibrous Histiocytoma    |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |    X           X     X           X              X                        |         22 |
      Pancreatic, Leukemia Mononuclear     |    X     X  X  X     X     X     X              X     X                  |         29 |
      Renal, Leukemia Mononuclear          |             X                                   X                        |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 |    X     X  X                    X              X                        |         28 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 | X  X        X  X     X           X              X     X                  |         32 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 | X  X  X  X  X  X     X     X  X  X  X        X  X  X  X                  |         51 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +                  |  63        |
      Leukemia Mononuclear                 |    X        X  X                 X              X                        |         16 |
      Thymoma Benign                       |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Carcinoma                            |       X                                                                  |          1 |
      Fibroadenoma                         |                            X  X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +                  |  67        |
      Keratoacanthoma                      |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
      Subcutaneous Tissue, Melanoma Benign |    X                                                                     |          2 |
      Subcutaneous Tissue, Melanoma        |                                                                          |            |
          Malignant                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  49                                                               
NTP Experiment-Test: 05094-03                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 03/17/97  
Route: DOSED FEED                                                                                                 Time: 12:46:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|                 |            |
                             DAY ON TEST   | 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|                 |            |
                                           | 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|                 |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                 |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                 |     A      |
    1.2%                                   | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                 |     L      |
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                 |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Fibrous Histiocytoma                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |    X        X                    X                                       |          8 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Alveolar/Bronchiolar Adenoma         |       X                                                                  |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |    X        X  X     X                                X                  |         31 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Schwannoma Malignant                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  68        |
      Leukemia Mononuclear                 |    X        X  X           X     X              X     X                  |         25 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                       +                  |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 |    X           X                                                         |          5 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
      Transitional Epithelium, Papilloma   |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                  |  69        |
      Leukemia Mononuclear                 | X  X  X  X  X  X     X     X  X  X  X        X  X  X  X                  |         51 |
      Mesothelioma Malignant               |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

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