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TDMS Study 05094-02 Pathology Tables

NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96
Route: DOSED FEED                                                                                                 Time: 06:28:06




       Facility:  Southern Research Institute

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60           60                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23            7           17           16           20                        
    Natural Death                                      2            2            4            5            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           41           29           29           29                        

  Animals Examined Microscopically                    60           60           60           60           60                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (59)         (58)         (59)         (60)                      
      Parasite Metazoan                                3 (5%)       2 (3%)       2 (3%)       3 (5%)       4 (7%)                   
   Intestine Large, Rectum                            (60)         (58)         (60)         (60)         (60)                      
      Parasite Metazoan                                3 (5%)       6 (10%)      5 (8%)      11 (18%)      4 (7%)                   
   Intestine Large, Cecum                             (59)         (60)         (60)         (59)         (59)                      
      Edema                                            2 (3%)                                 2 (3%)       1 (2%)                   
      Parasite Metazoan                                2 (3%)       1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
      Ulcer                                                                                   1 (2%)                                
   Intestine Small, Ileum                             (59)         (59)         (60)         (60)         (60)                      
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (60)         (60)         (60)         (60)         (60)                      
      Angiectasis                                                                1 (2%)       4 (7%)                                
      Basophilic Focus                                47 (78%)     47 (78%)     48 (80%)     49 (82%)     48 (80%)                  
      Clear Cell Focus                                 3 (5%)       2 (3%)       3 (5%)       8 (13%)      9 (15%)                  
      Cyst                                                                       1 (2%)       2 (3%)       2 (3%)                   
      Developmental Malformation                       1 (2%)                                                                       
      Eosinophilic Focus                              19 (32%)     17 (28%)     16 (27%)     10 (17%)     20 (33%)                  
      Granuloma                                        7 (12%)      6 (10%)     14 (23%)      9 (15%)      2 (3%)                   
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)                                 1 (2%)                   
      Hepatodiaphragmatic Nodule                      10 (17%)      7 (12%)      7 (12%)      8 (13%)     12 (20%)                  
      Inflammation, Subacute                           3 (5%)       1 (2%)                                                          
      Mixed Cell Focus                                10 (17%)      4 (7%)       4 (7%)       5 (8%)       6 (10%)                  
      Thrombosis                                                                              1 (2%)                                
      Bile Duct, Hyperplasia                          11 (18%)     10 (17%)     12 (20%)     12 (20%)      9 (15%)                  
      Centrilobular, Necrosis                          1 (2%)       2 (3%)                    1 (2%)                                
      Hepatocyte, Hyperplasia, Focal                                             1 (2%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            7 (12%)      1 (2%)       6 (10%)      2 (3%)                                
      Kupffer Cell, Hyperplasia                        1 (2%)                    1 (2%)                                             
      Kupffer Cell, Pigmentation                       4 (7%)       4 (7%)       1 (2%)       6 (10%)     10 (17%)                  
      Lobules, Necrosis                                6 (10%)      1 (2%)       3 (5%)                    6 (10%)                  
   Mesentery                                          (11)         (2)          (8)          (12)         (6)                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Accessory Spleen                                 1 (9%)                                 2 (17%)      1 (17%)                  
      Fat, Necrosis                                   10 (91%)      2 (100%)     7 (88%)      9 (75%)      6 (100%)                 
   Oral Mucosa                                                     (1)          (1)                       (1)                       
      Hyperplasia                                                                                          1 (100%)                 
   Pancreas                                           (60)         (59)         (60)         (60)         (60)                      
      Atrophy                                         19 (32%)     18 (31%)     20 (33%)     16 (27%)     12 (20%)                  
      Cyst                                                          1 (2%)                                                          
      Edema                                                                      1 (2%)                                             
      Acinus, Cytoplasmic Alteration                   1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Acinus, Hyperplasia, Focal                       1 (2%)                    4 (7%)       2 (3%)                                
   Salivary Glands                                    (59)         (60)         (60)         (60)         (60)                      
      Atrophy                                          1 (2%)                    2 (3%)                                             
      Hyperplasia                                      1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (60)         (60)                      
      Edema                                            2 (3%)                    1 (2%)       1 (2%)                                
      Ulcer                                                         1 (2%)       1 (2%)                    1 (2%)                   
      Mucosa, Hyperplasia                              1 (2%)                    2 (3%)       2 (3%)       1 (2%)                   
   Stomach, Glandular                                 (60)         (60)         (60)         (60)         (60)                      
      Edema                                                                                   1 (2%)                                
      Erosion                                          1 (2%)                    2 (3%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            3 (5%)                    1 (2%)       1 (2%)                                
   Tongue                                             (3)          (1)                       (1)          (1)                       
      Epithelium, Hyperplasia                          1 (33%)                                1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)         (60)                      
      Cardiomyopathy                                  17 (28%)     14 (23%)     22 (37%)     24 (40%)     13 (22%)                  
      Mineralization                                                                                       1 (2%)                   
      Thrombosis                                       1 (2%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)         (60)                      
      Accessory Adrenal Cortical Nodule                7 (12%)     10 (17%)      7 (12%)     10 (17%)     10 (17%)                  
      Angiectasis                                     27 (45%)     16 (27%)     29 (48%)     33 (55%)     32 (53%)                  
      Cyst                                                                                                 2 (3%)                   
      Degeneration, Fatty                             11 (18%)      4 (7%)      16 (27%)     11 (18%)      4 (7%)                   
      Hemorrhage                                                                 1 (2%)                    1 (2%)                   
      Hyperplasia, Focal                               9 (15%)     10 (17%)      4 (7%)       2 (3%)       3 (5%)                   
      Hypertrophy, Focal                              10 (17%)      3 (5%)      12 (20%)      9 (15%)                               
      Metaplasia, Osseous                                           1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis                                                                                1 (2%)                                
   Adrenal Medulla                                    (59)         (60)         (59)         (60)         (60)                      
      Hyperplasia                                      1 (2%)       3 (5%)       2 (3%)       4 (7%)       1 (2%)                   
   Islets, Pancreatic                                 (60)         (59)         (60)         (60)         (60)                      
      Hyperplasia                                                                1 (2%)                                             
      Metaplasia, Hepatocyte                                                                               1 (2%)                   
   Parathyroid Gland                                  (56)         (56)         (59)         (59)         (58)                      
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (59)         (57)         (60)         (58)         (60)                      
      Pars Distalis, Angiectasis                       8 (14%)      8 (14%)      9 (15%)      9 (16%)      7 (12%)                  
      Pars Distalis, Cyst                             30 (51%)     10 (18%)     30 (50%)     24 (41%)     20 (33%)                  
      Pars Distalis, Hemorrhage                                                               1 (2%)                                
      Pars Distalis, Hyperplasia                                                                           1 (2%)                   
      Pars Distalis, Hyperplasia, Focal               13 (22%)     14 (25%)     13 (22%)      9 (16%)     12 (20%)                  
      Pars Intermedia, Angiectasis                                               3 (5%)       3 (5%)                                
      Pars Intermedia, Cyst                                         2 (4%)       3 (5%)                                             
      Pars Intermedia, Hyperplasia                     1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (59)         (60)         (60)         (60)         (60)                      
      Ultimobranchial Cyst                             3 (5%)                    4 (7%)       1 (2%)                                
      C-Cell, Hyperplasia                              6 (10%)      4 (7%)       7 (12%)      8 (13%)      3 (5%)                   
      Follicle, Cyst                                                             1 (2%)       1 (2%)                                
      Follicular Cell, Hyperplasia                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                 (1)                       
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (60)         (60)         (60)                      
      Ectasia                                         12 (20%)      4 (7%)      21 (35%)     13 (22%)     11 (18%)                  
      Hyperplasia                                      1 (2%)       1 (2%)       4 (7%)       2 (3%)       1 (2%)                   
      Inflammation, Chronic                            6 (10%)      3 (5%)       6 (10%)      4 (7%)       1 (2%)                   
      Inflammation, Suppurative                        3 (5%)       4 (7%)       5 (8%)       6 (10%)      3 (5%)                   
   Ovary                                              (60)         (60)         (60)         (60)         (60)                      
      Cyst                                             3 (5%)                    5 (8%)       6 (10%)      6 (10%)                  
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
   Uterus                                             (60)         (60)         (60)         (60)         (60)                      
      Cyst                                                                                    1 (2%)                                
      Hydrometra                                       4 (7%)       5 (8%)       4 (7%)       5 (8%)       5 (8%)                   
      Hyperplasia, Cystic                              4 (7%)       4 (7%)       4 (7%)       1 (2%)      12 (20%)                  
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)         (60)                      
      Hypercellularity                                 1 (2%)       2 (3%)       2 (3%)                    1 (2%)                   
      Myelofibrosis                                    4 (7%)       3 (5%)       3 (5%)       6 (10%)      6 (10%)                  
   Lymph Node                                         (12)         (13)         (12)         (17)         (16)                      
      Iliac, Hyperplasia, Lymphoid                                               1 (8%)                                             
      Iliac, Pigmentation                                                        1 (8%)                                             
      Mediastinal, Hemorrhage                          1 (8%)       3 (23%)      2 (17%)      2 (12%)      2 (13%)                  
      Mediastinal, Hyperplasia, Lymphoid                                         1 (8%)                                             
      Mediastinal, Pigmentation                        2 (17%)      6 (46%)      6 (50%)     10 (59%)     10 (63%)                  
      Pancreatic, Hemorrhage                                                                  1 (6%)                                
      Pancreatic, Pigmentation                         1 (8%)                    2 (17%)      3 (18%)      3 (19%)                  
      Renal, Hemorrhage                                             1 (8%)       2 (17%)      2 (12%)                               
      Renal, Hyperplasia, Lymphoid                                               1 (8%)                                             
      Renal, Pigmentation                              1 (8%)       4 (31%)      5 (42%)      3 (18%)      4 (25%)                  
   Lymph Node, Mandibular                             (59)         (60)         (60)         (60)         (60)                      
      Ectasia                                          2 (3%)       2 (3%)       5 (8%)       4 (7%)       5 (8%)                   
      Hemorrhage                                       5 (8%)       8 (13%)      9 (15%)      3 (5%)       6 (10%)                  
      Hyperplasia, Lymphoid                            8 (14%)      3 (5%)       7 (12%)      4 (7%)                                
      Pigmentation                                    15 (25%)     21 (35%)     27 (45%)     17 (28%)     20 (33%)                  
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)         (60)                      
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage                                       3 (5%)       2 (3%)       3 (5%)       3 (5%)       2 (3%)                   
      Hyperplasia, Lymphoid                            1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)         (60)                      
      Developmental Malformation                                                                           1 (2%)                   
      Fibrosis                                         1 (2%)       3 (5%)       2 (3%)       3 (5%)       1 (2%)                   
      Hematopoietic Cell Proliferation                11 (18%)      5 (8%)      15 (25%)     11 (18%)     17 (28%)                  
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                       29 (48%)     23 (38%)     30 (50%)     31 (52%)     39 (65%)                  
   Thymus                                             (58)         (59)         (59)         (60)         (58)                      
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (58)         (60)         (60)         (60)                      
      Ectasia                                         12 (20%)      5 (9%)       9 (15%)     20 (33%)     11 (18%)                  
      Hyperplasia                                     33 (56%)      9 (16%)     41 (68%)     25 (42%)     18 (30%)                  
      Inflammation, Chronic Active                                                            1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)         (60)                      
      Acanthosis                                       1 (2%)                    2 (3%)                    1 (2%)                   
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)                    1 (2%)                                
      Developmental Malformation                                                              1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Hemorrhage                                                                              2 (3%)                                
      Hyperkeratosis                                   3 (5%)       4 (7%)       2 (3%)       3 (5%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                            2 (3%)       1 (2%)       4 (7%)                    2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)         (60)                      
      Cranium, Hyperostosis                                                      1 (2%)                                             
      Cranium, Osteopetrosis                           7 (12%)      3 (5%)      11 (18%)     10 (17%)      7 (12%)                  
      Femur, Osteopetrosis                             5 (8%)       4 (7%)       7 (12%)      7 (12%)      5 (8%)                   
      Femur, Osteosclerosis                                                                   1 (2%)                                
      Rib, Osteopetrosis                                            1 (2%)                                 1 (2%)                   
   Skeletal Muscle                                    (1)                                                 (1)                       
      Hemorrhage                                       1 (100%)                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)         (60)                      
      Compression                                      9 (15%)      1 (2%)       6 (10%)      9 (15%)      8 (13%)                  
      Gliosis                                          1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)       1 (2%)       1 (2%)                                
      Hydrocephalus                                    2 (3%)       1 (2%)       3 (5%)                    1 (2%)                   
      Necrosis                                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)         (60)                      
      Congestion                                                                              1 (2%)       1 (2%)                   
      Edema                                                         1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       2 (3%)                    1 (2%)                   
      Infiltration Cellular, Histiocyte               23 (38%)     20 (33%)     23 (38%)     21 (35%)     21 (35%)                  
      Inflammation, Subacute                           1 (2%)                                 2 (3%)       1 (2%)                   
      Alveolar Epithelium, Hyperplasia                 2 (3%)       1 (2%)                    4 (7%)       2 (3%)                   
   Nose                                               (60)         (60)         (60)         (60)         (60)                      
      Exudate                                          7 (12%)      3 (5%)       4 (7%)       2 (3%)       4 (7%)                   
      Foreign Body                                     5 (8%)       1 (2%)       4 (7%)       1 (2%)                                
      Fungus                                           4 (7%)       2 (3%)       1 (2%)       1 (2%)                                
      Mucosa, Hyperplasia                              3 (5%)       3 (5%)       2 (3%)       2 (3%)       1 (2%)                   
      Mucosa, Metaplasia, Squamous                     4 (7%)                                 1 (2%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)                       (1)          (3)                       
      Atrophy                                          1 (50%)                                                                      
      Cataract                                                      2 (100%)                               2 (67%)                  
      Hemorrhage                                       1 (50%)                                             1 (33%)                  
      Retina, Degeneration                                          2 (100%)                               2 (67%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)         (60)                      
      Calculus Micro Observation Only                                                                      1 (2%)                   
      Cyst                                             1 (2%)       1 (2%)       2 (3%)       2 (3%)       2 (3%)                   
      Hydronephrosis                                                2 (3%)                    1 (2%)       1 (2%)                   
      Mineralization                                  53 (88%)     58 (97%)     43 (72%)     46 (77%)     43 (72%)                  
      Nephropathy                                     41 (68%)     34 (57%)     57 (95%)     53 (88%)     55 (92%)                  
      Renal Tubule, Atrophy                            1 (2%)                    1 (2%)       3 (5%)       2 (3%)                   
      Renal Tubule, Cytoplasmic Alteration             1 (2%)                                                                       
      Renal Tubule, Dilatation                         1 (2%)                                 2 (3%)       1 (2%)                   
      Renal Tubule, Necrosis                           1 (2%)                                              1 (2%)                   
      Renal Tubule, Pigmentation                      59 (98%)     57 (95%)     59 (98%)     59 (98%)     57 (95%)                  
      Transitional Epithelium, Hyperplasia                          4 (7%)       3 (5%)       7 (12%)      4 (7%)                   
   Ureter                                                                                    (1)          (1)                       
      Dilatation                                                                                           1 (100%)                 
      Transitional Epithelium, Hyperplasia                                                                 1 (100%)                 
   Urinary Bladder                                    (60)         (60)         (60)         (60)         (60)                      
      Edema                                            1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Transitional Epithelium, Hyperplasia             4 (7%)                                 1 (2%)      10 (17%)                  
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60           60           60           60           60                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           15           19           26           26                        
    Natural Death                                      3            1           11            2            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           33           20           22           22                        
  Other                                                             1                                                               

  Animals Examined Microscopically                    60           60           60           60           60                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (54)         (59)         (58)         (59)         (58)                      
      Dilatation                                       1 (2%)                                                                       
      Parasite Metazoan                                6 (11%)      6 (10%)      3 (5%)       5 (8%)       4 (7%)                   
   Intestine Large, Rectum                            (59)         (57)         (60)         (60)         (59)                      
      Parasite Metazoan                               12 (20%)      8 (14%)      5 (8%)       3 (5%)       9 (15%)                  
   Intestine Large, Cecum                             (57)         (60)         (60)         (60)         (60)                      
      Edema                                            4 (7%)                    2 (3%)       4 (7%)                                
      Parasite Metazoan                                                          2 (3%)                    1 (2%)                   
      Ulcer                                            1 (2%)                                              1 (2%)                   
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)         (60)                      
      Erosion                                                                    1 (2%)                                             
   Intestine Small, Ileum                             (59)         (60)         (60)         (59)         (60)                      
      Parasite Metazoan                                             1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)         (60)                      
      Angiectasis                                      1 (2%)       4 (7%)       2 (3%)       5 (8%)       2 (3%)                   
      Basophilic Focus                                28 (47%)     22 (37%)     24 (40%)     20 (33%)     15 (25%)                  
      Clear Cell Focus                                17 (28%)      9 (15%)     10 (17%)      8 (13%)      9 (15%)                  
      Cyst                                                                                                 2 (3%)                   
      Degeneration, Cystic                             7 (12%)      7 (12%)      7 (12%)     10 (17%)      6 (10%)                  
      Developmental Malformation                                    1 (2%)                                                          
      Eosinophilic Focus                               6 (10%)     10 (17%)      9 (15%)      8 (13%)      6 (10%)                  
      Granuloma                                                                  1 (2%)       1 (2%)       8 (13%)                  
      Hematopoietic Cell Proliferation                              1 (2%)       2 (3%)                                             
      Hemorrhage                                                                                           2 (3%)                   
      Hepatodiaphragmatic Nodule                       4 (7%)       4 (7%)       4 (7%)       1 (2%)       8 (13%)                  
      Inflammation, Subacute                                        1 (2%)       1 (2%)       3 (5%)       5 (8%)                   
      Mixed Cell Focus                                 6 (10%)      7 (12%)      5 (8%)       8 (13%)      7 (12%)                  
      Bile Duct, Hyperplasia                          44 (73%)     39 (65%)     45 (75%)     42 (70%)     27 (45%)                  
      Centrilobular, Necrosis                          1 (2%)                    4 (7%)                    2 (3%)                   
      Hepatocyte, Hyperplasia, Focal                                             1 (2%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            8 (13%)     12 (20%)      2 (3%)       3 (5%)       4 (7%)                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Pigmentation                       2 (3%)                    1 (2%)       6 (10%)      6 (10%)                  
      Lobules, Necrosis                                2 (3%)       2 (3%)                    2 (3%)       3 (5%)                   
   Mesentery                                          (11)         (15)         (15)         (17)         (6)                       
      Accessory Spleen                                              2 (13%)      3 (20%)                   2 (33%)                  
      Angiectasis                                      1 (9%)                                                                       
      Fibrosis                                         1 (9%)                                 1 (6%)                                
      Hemorrhage                                                                              1 (6%)                                
      Fat, Necrosis                                    9 (82%)     11 (73%)     10 (67%)     11 (65%)      3 (50%)                  
   Pancreas                                           (60)         (60)         (59)         (60)         (60)                      
      Atrophy                                         32 (53%)     37 (62%)     37 (63%)     32 (53%)     33 (55%)                  
      Cytoplasmic Alteration                                                                  1 (2%)       1 (2%)                   
      Edema                                                                                   3 (5%)                                
      Acinus, Cytoplasmic Alteration                   1 (2%)       1 (2%)                    1 (2%)                                
      Acinus, Hyperplasia, Focal                       4 (7%)       2 (3%)       7 (12%)      9 (15%)     12 (20%)                  
   Salivary Glands                                    (60)         (60)         (60)         (60)         (60)                      
      Cytoplasmic Alteration                                                                  1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)         (60)                      
      Edema                                            1 (2%)                                 4 (7%)       3 (5%)                   
      Ulcer                                            2 (3%)       1 (2%)       1 (2%)       6 (10%)      3 (5%)                   
      Mucosa, Hyperplasia                              2 (3%)       1 (2%)                    3 (5%)       1 (2%)                   
   Stomach, Glandular                                 (60)         (60)         (60)         (60)         (60)                      
      Edema                                            2 (3%)       1 (2%)                    3 (5%)                                
      Erosion                                          2 (3%)                    5 (8%)       2 (3%)       1 (2%)                   
      Ulcer                                            2 (3%)       1 (2%)                    1 (2%)       1 (2%)                   
      Mucosa, Hyperplasia                                           1 (2%)                                                          
   Tongue                                                                       (1)          (1)          (1)                       
      Epithelium, Hyperplasia                                                    1 (100%)                  1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (60)         (60)                      
      Hypertrophy                                      2 (3%)       2 (3%)                    1 (2%)                                
      Inflammation, Subacute                           2 (3%)       2 (3%)                    1 (2%)                                
      Thrombosis                                                                              1 (2%)                                
   Heart                                              (60)         (60)         (60)         (60)         (60)                      
      Cardiomyopathy                                  40 (67%)     29 (48%)     36 (60%)     30 (50%)     40 (67%)                  
      Inflammation, Chronic                                         1 (2%)                                                          
      Thrombosis                                       2 (3%)                    3 (5%)       1 (2%)       5 (8%)                   
      Schwann Cell, Hyperplasia                                     1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)         (60)                      
      Accessory Adrenal Cortical Nodule               15 (25%)     13 (22%)     12 (20%)     10 (17%)      9 (15%)                  
      Angiectasis                                                   8 (13%)      1 (2%)       3 (5%)       2 (3%)                   
      Degeneration, Fatty                              3 (5%)       4 (7%)       5 (8%)       6 (10%)      8 (13%)                  
      Hemorrhage                                       1 (2%)       1 (2%)                                 1 (2%)                   
      Hyperplasia, Focal                               8 (13%)      9 (15%)      6 (10%)     11 (18%)      4 (7%)                   
      Hypertrophy                                                                1 (2%)                                             
      Hypertrophy, Focal                               2 (3%)       3 (5%)       2 (3%)       5 (8%)       2 (3%)                   
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Adrenal Medulla                                    (60)         (60)         (60)         (60)         (60)                      
      Hyperplasia                                      6 (10%)      6 (10%)     12 (20%)     17 (28%)     12 (20%)                  
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)         (60)                      
      Hyperplasia                                      3 (5%)                    2 (3%)                    2 (3%)                   
      Metaplasia, Hepatocyte                                                     1 (2%)                                             
   Parathyroid Gland                                  (58)         (56)         (59)         (59)         (59)                      
      Hyperplasia                                                                             1 (2%)       1 (2%)                   
   Pituitary Gland                                    (59)         (60)         (60)         (60)         (59)                      
      Pars Distalis, Angiectasis                       3 (5%)       4 (7%)       1 (2%)       3 (5%)                                
      Pars Distalis, Cyst                              4 (7%)       4 (7%)       5 (8%)       7 (12%)      3 (5%)                   
      Pars Distalis, Hemorrhage                                                                            1 (2%)                   
      Pars Distalis, Hyperplasia                       1 (2%)                    1 (2%)       1 (2%)       2 (3%)                   
      Pars Distalis, Hyperplasia, Focal               10 (17%)     12 (20%)     12 (20%)     11 (18%)      7 (12%)                  
      Pars Distalis, Necrosis                                                                              1 (2%)                   
      Pars Intermedia, Angiectasis                     3 (5%)       2 (3%)                    2 (3%)                                
      Pars Intermedia, Cyst                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Pars Intermedia, Hyperplasia                                  2 (3%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)         (60)                      
      Hyperplasia                                                   1 (2%)                                                          
      Ultimobranchial Cyst                             2 (3%)       2 (3%)       2 (3%)       2 (3%)       4 (7%)                   
      C-Cell, Hyperplasia                              4 (7%)      12 (20%)     10 (17%)     13 (22%)      7 (12%)                  
      Follicle, Cyst                                   2 (3%)                    2 (3%)       1 (2%)       5 (8%)                   
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)         (60)                      
      Atypia Cellular                                 29 (48%)     33 (55%)     28 (47%)     30 (50%)     39 (65%)                  
      Hypospermia                                     34 (57%)     41 (68%)     37 (62%)     41 (68%)     43 (72%)                  
   Preputial Gland                                    (60)         (60)         (60)         (60)         (60)                      
      Ectasia                                         11 (18%)      9 (15%)     14 (23%)     20 (33%)     14 (23%)                  

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hyperplasia                                      1 (2%)       2 (3%)       2 (3%)       2 (3%)       1 (2%)                   
      Inflammation, Chronic                           31 (52%)     28 (47%)     23 (38%)     25 (42%)     23 (38%)                  
      Inflammation, Suppurative                       11 (18%)      5 (8%)       9 (15%)     15 (25%)      7 (12%)                  
   Prostate                                           (60)         (60)         (60)         (60)         (60)                      
      Corpora Amylacea                                18 (30%)     26 (43%)     30 (50%)     37 (62%)     37 (62%)                  
      Fibrosis                                                                                             1 (2%)                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                       34 (57%)     34 (57%)     34 (57%)     32 (53%)     23 (38%)                  
      Epithelium, Hyperplasia                          5 (8%)       5 (8%)       6 (10%)      6 (10%)      3 (5%)                   
   Seminal Vesicle                                    (60)         (60)         (60)         (60)         (60)                      
      Dilatation                                       4 (7%)                    2 (3%)                    1 (2%)                   
   Testes                                             (60)         (60)         (60)         (60)         (60)                      
      Mineralization                                                             1 (2%)                                             
      Interstitial Cell, Hyperplasia                   9 (15%)      9 (15%)     13 (22%)     12 (20%)     10 (17%)                  
      Seminiferous Tubule, Atrophy                     2 (3%)       2 (3%)       5 (8%)       6 (10%)      4 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)         (60)                      
      Hypercellularity                                 1 (2%)       2 (3%)       4 (7%)       1 (2%)                                
      Myelofibrosis                                    2 (3%)       3 (5%)       4 (7%)       4 (7%)       5 (8%)                   
   Lymph Node                                         (25)         (14)         (22)         (32)         (20)                      
      Deep Cervical, Hemorrhage                        1 (4%)                                                                       
      Deep Cervical, Pigmentation                      1 (4%)                                                                       
      Iliac, Hemorrhage                                1 (4%)                                                                       
      Iliac, Hyperplasia, Lymphoid                     1 (4%)                                                                       
      Iliac, Pigmentation                              1 (4%)                                                                       
      Mediastinal, Fibrosis                                                                   1 (3%)                                
      Mediastinal, Hemorrhage                          7 (28%)      4 (29%)      5 (23%)      2 (6%)       1 (5%)                   
      Mediastinal, Hyperplasia, Lymphoid                            1 (7%)                                                          
      Mediastinal, Pigmentation                        7 (28%)      4 (29%)      7 (32%)     12 (38%)      6 (30%)                  
      Pancreatic, Ectasia                                                                     1 (3%)                                
      Pancreatic, Hemorrhage                                                     1 (5%)                    1 (5%)                   
      Pancreatic, Hyperplasia, Lymphoid                             1 (7%)                    1 (3%)                                
      Pancreatic, Pigmentation                                      1 (7%)                    4 (13%)      2 (10%)                  
      Renal, Hyperplasia, Lymphoid                     1 (4%)                                                                       
      Renal, Pigmentation                              2 (8%)                    2 (9%)       3 (9%)       2 (10%)                  
   Lymph Node, Mandibular                             (59)         (58)         (59)         (60)         (60)                      
      Congestion                                       1 (2%)                    2 (3%)                                             
      Ectasia                                          6 (10%)      5 (9%)       4 (7%)       5 (8%)       4 (7%)                   
      Hemorrhage                                       6 (10%)     10 (17%)      3 (5%)       3 (5%)       6 (10%)                  
      Hyperplasia, Lymphoid                            4 (7%)       6 (10%)      3 (5%)       1 (2%)       5 (8%)                   
      Pigmentation                                     2 (3%)       7 (12%)      5 (8%)       1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)         (60)                      
      Ectasia                                          7 (12%)      1 (2%)       4 (7%)       2 (3%)       1 (2%)                   
      Hemorrhage                                       1 (2%)       3 (5%)       3 (5%)       2 (3%)       4 (7%)                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            2 (3%)                    3 (5%)       1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (60)         (60)                      
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                         5 (8%)       7 (12%)     11 (18%)     14 (23%)     10 (17%)                  
      Granuloma                                                                                            1 (2%)                   
      Hematopoietic Cell Proliferation                 4 (7%)       6 (10%)      8 (13%)      5 (8%)       8 (13%)                  
      Hemorrhage                                                                 1 (2%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                    1 (2%)                                
      Pigmentation, Hemosiderin                       24 (40%)     11 (18%)     11 (18%)     12 (20%)     13 (22%)                  
      Lymphoid Follicle, Atrophy                                                 1 (2%)                                             
   Thymus                                             (59)         (58)         (58)         (60)         (57)                      
      Cyst                                             1 (2%)                                 1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (58)         (58)         (57)         (58)                      
      Hyperplasia                                     10 (18%)      8 (14%)     16 (28%)     10 (18%)     12 (21%)                  
   Skin                                               (60)         (60)         (60)         (60)         (60)                      
      Acanthosis                                                    1 (2%)       2 (3%)       2 (3%)      10 (17%)                  
      Cyst Epithelial Inclusion                                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                                                                           1 (2%)                   
      Hyperkeratosis                                                1 (2%)       2 (3%)       3 (5%)      13 (22%)                  
      Inflammation, Chronic                                         1 (2%)       1 (2%)       1 (2%)       2 (3%)                   
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                 3 (5%)                   
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)         (60)                      
      Cranium, Hyperostosis                                                                                1 (2%)                   
      Cranium, Osteopetrosis                           1 (2%)                    1 (2%)       1 (2%)                                
      Femur, Osteopetrosis                             1 (2%)       2 (3%)                    3 (5%)       1 (2%)                   
      Rib, Osteopetrosis                                                                      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)         (60)                      
      Compression                                      4 (7%)       4 (7%)       5 (8%)                    2 (3%)                   
      Gliosis                                                                                              1 (2%)                   
      Hemorrhage                                                                                           2 (3%)                   
      Hydrocephalus                                    2 (3%)       2 (3%)       1 (2%)                    1 (2%)                   
      Mineralization                                   1 (2%)                                              1 (2%)                   
      Necrosis                                                                                1 (2%)       2 (3%)                   
      Cerebellum, Necrosis                                                                                 1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)         (60)                      
      Congestion                                       1 (2%)       1 (2%)       2 (3%)                    1 (2%)                   
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                    1 (2%)                   
      Infiltration Cellular, Histiocyte               15 (25%)     16 (27%)     12 (20%)     14 (23%)      8 (13%)                  
      Inflammation, Subacute                           1 (2%)       1 (2%)       3 (5%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 8 (13%)      6 (10%)      2 (3%)       7 (12%)      3 (5%)                   
   Nose                                               (60)         (60)         (60)         (60)         (60)                      
      Exudate                                         17 (28%)     14 (23%)     12 (20%)     14 (23%)     17 (28%)                  
      Foreign Body                                     8 (13%)      4 (7%)       6 (10%)      7 (12%)      5 (8%)                   
      Fungus                                          12 (20%)     12 (20%)      6 (10%)      8 (13%)     11 (18%)                  
      Mucosa, Hyperplasia                             11 (18%)      9 (15%)      8 (13%)      6 (10%)     12 (20%)                  
      Mucosa, Metaplasia, Squamous                     9 (15%)      7 (12%)      6 (10%)      7 (12%)      2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                 (2)                       
      Atrophy                                          1 (100%)                                                                     
      Cataract                                                                                             1 (50%)                  
      Hemorrhage                                                                                           1 (50%)                  
      Retina, Degeneration                                                                                 1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)         (60)                      
      Cyst                                                                       2 (3%)       3 (5%)                                
      Inflammation, Suppurative                                     1 (2%)       3 (5%)       9 (15%)      4 (7%)                   
      Mineralization                                                1 (2%)       1 (2%)       2 (3%)                                
      Nephropathy                                     58 (97%)     57 (95%)     57 (95%)     60 (100%)    57 (95%)                  
      Papilla, Inflammation, Suppurative                                         1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05094-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:28:06  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Atrophy                                                      1 (2%)       1 (2%)                                
      Renal Tubule, Cytoplasmic Alteration                          2 (3%)                                 1 (2%)                   
      Renal Tubule, Dilatation                                                   1 (2%)                    1 (2%)                   
      Renal Tubule, Hyaline Droplet                                 1 (2%)                                                          
      Renal Tubule, Hyperplasia                                                               2 (3%)                                
      Renal Tubule, Necrosis                                        1 (2%)                                                          
      Renal Tubule, Pigmentation                      59 (98%)     59 (98%)     58 (97%)     60 (100%)    60 (100%)                 
      Transitional Epithelium, Hyperplasia             6 (10%)                  10 (17%)      6 (10%)      1 (2%)                   
   Urinary Bladder                                    (60)         (60)         (60)         (60)         (60)                      
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                                                  2 (3%)                                             
      Transitional Epithelium, Hyperplasia                                                                 2 (3%)                   
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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