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TDMS Study 05094-02 Pathology Tables

NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96
Route: DOSED FEED                                                                                                 Time: 06:46:23




       Facility:  Southern Research Institute

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60           60                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23            7           17           16           20                        
    Natural Death                                      2            2            4            5            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           41           29           29           29                        

  Animals Examined Microscopically                    60           60           60           60           60                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (59)         (58)         (59)         (60)                      
   Intestine Large, Cecum                             (59)         (60)         (60)         (59)         (59)                      
   Intestine Small, Jejunum                           (60)         (60)         (59)         (60)         (59)                      
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (59)         (59)         (60)         (60)         (60)                      
   Liver                                              (60)         (60)         (60)         (60)         (60)                      
      Carcinoma, Metastatic, Intestine Small,                                                                                       
          Jejunum                                                   1 (2%)                                                          
      Hepatocellular Adenoma                                                                  2 (3%)       2 (3%)                   
   Mesentery                                          (11)         (2)          (8)          (12)         (6)                       
      Leiomyosarcoma, Metastatic, Uterus                                                      1 (8%)                                
      Lipoma                                                                     1 (13%)                                            
      Liposarcoma                                      1 (9%)                                                                       
      Schwannoma Malignant                                                       1 (13%)                                            
   Oral Mucosa                                                     (1)          (1)                       (1)                       
      Squamous Cell Carcinoma                                                    1 (100%)                                           
      Squamous Cell Papilloma                                       1 (100%)                                                        
   Pancreas                                           (60)         (59)         (60)         (60)         (60)                      
      Acinus, Adenoma                                                                                      2 (3%)                   
   Salivary Glands                                    (59)         (60)         (60)         (60)         (60)                      
   Stomach, Forestomach                               (60)         (60)         (60)         (60)         (60)                      
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (60)         (60)         (60)         (60)                      
   Tongue                                             (3)          (1)                       (1)          (1)                       
      Squamous Cell Papilloma                          2 (67%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)         (60)                      
      Schwannoma Malignant                             1 (2%)       1 (2%)                                 1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)         (60)                      
      Adenoma                                          1 (2%)                    5 (8%)       1 (2%)                                
      Carcinoma                                                     1 (2%)                    1 (2%)                                
   Adrenal Medulla                                    (59)         (60)         (59)         (60)         (60)                      
      Ganglioneuroma                                                             1 (2%)                                             
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          1 (2%)                    2 (3%)                    1 (2%)                   
   Islets, Pancreatic                                 (60)         (59)         (60)         (60)         (60)                      
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                                               2 (3%)                                
   Parathyroid Gland                                  (56)         (56)         (59)         (59)         (58)                      
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (59)         (57)         (60)         (58)         (60)                      
      Pars Distalis, Adenoma                          19 (32%)      8 (14%)     27 (45%)     26 (45%)     13 (22%)                  
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Distalis, Carcinoma                         2 (3%)                                                                       
      Pars Intermedia, Adenoma                                                                             1 (2%)                   
   Thyroid Gland                                      (59)         (60)         (60)         (60)         (60)                      
      C-Cell, Adenoma                                  4 (7%)       1 (2%)       5 (8%)       3 (5%)       2 (3%)                   
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                1 (2%)                    2 (3%)                                             
      C-Cell, Carcinoma, Multiple                                                                          1 (2%)                   
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                    1 (2%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                 (1)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (60)         (60)         (60)                      
      Adenoma                                          3 (5%)       2 (3%)       4 (7%)       4 (7%)       4 (7%)                   
      Carcinoma                                        4 (7%)       1 (2%)       6 (10%)      5 (8%)                                
   Ovary                                              (60)         (60)         (60)         (60)         (60)                      
      Arrhenoblastoma NOS                                                                     1 (2%)                                
      Granulosa Cell Tumor Benign                      2 (3%)                                                                       
   Uterus                                             (60)         (60)         (60)         (60)         (60)                      

                                                             Page   3                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Deciduoma Benign                                 1 (2%)                                              1 (2%)                   
      Leiomyoma                                        1 (2%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                 1 (2%)                                
      Polyp Stromal                                    7 (12%)      4 (7%)      10 (17%)      6 (10%)      7 (12%)                  
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)         (60)                      
   Lymph Node                                         (12)         (13)         (12)         (17)         (16)                      
   Lymph Node, Mandibular                             (59)         (60)         (60)         (60)         (60)                      
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)         (60)                      
   Spleen                                             (60)         (60)         (60)         (60)         (60)                      
   Thymus                                             (58)         (59)         (59)         (60)         (58)                      
      Carcinoma, Metastatic, Thyroid Gland                                                                 1 (2%)                   
      Thymoma Benign                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (58)         (60)         (60)         (60)                      
      Adenoma                                          2 (3%)                                                                       
      Carcinoma                                        2 (3%)                    1 (2%)       2 (3%)                                
      Fibroadenoma                                    28 (47%)      7 (12%)     31 (52%)     32 (53%)     11 (18%)                  
   Skin                                               (60)         (60)         (60)         (60)         (60)                      
      Basal Cell Adenoma                                            1 (2%)                                 1 (2%)                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Keratoacanthoma                                  1 (2%)       1 (2%)       1 (2%)                                             
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Trichoepithelioma                                             1 (2%)                                                          
      Sebaceous Gland, Carcinoma                                    1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)         (60)                      
      Astrocytoma Malignant                                                                   1 (2%)       1 (2%)                   
      Carcinoma                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           2 (3%)                                                                       

                                                             Page   4                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - cont                                                                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)         (60)                      
      Alveolar/Bronchiolar Adenoma                     2 (3%)                    1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)         (60)                      
      Hemangioma                                                                                           1 (2%)                   
      Renal Tubule, Adenoma                                         1 (2%)                                                          
      Renal Tubule, Carcinoma                          1 (2%)                                 1 (2%)                                
   Urinary Bladder                                    (60)         (60)         (60)         (60)         (60)                      
      Transitional Epithelium, Papilloma               1 (2%)                                              2 (3%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)        *(60)                      
      Leukemia Mononuclear                            22 (37%)     13 (22%)     20 (33%)     21 (35%)     19 (32%)                  
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     CONTROL      0.6%         1.2%         2.4%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53          33          52          48          42                           
     Total Primary Neoplasms                          117          50         124         116          70                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          20          47          43          31                           
     Total Benign Neoplasms                            81          30          90          80          48                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          20          31          28          22                           
     Total Malignant Neoplasms                         36          20          34          35          22                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1           1           1           1                           
     Total Metastatic Neoplasm                          2           1           1           1           1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60           60                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           15           19           26           26                        
    Natural Death                                      3            1           11            2            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           33           20           22           22                        
  Other                                                             1                                                               

  Animals Examined Microscopically                    60           60           60           60           60                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (54)         (59)         (58)         (59)         (58)                      
      Adenocarcinoma                                                                          1 (2%)                                
      Carcinoid Tumor Malignant                                                                            1 (2%)                   
   Intestine Large, Rectum                            (59)         (57)         (60)         (60)         (59)                      
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Large, Cecum                             (57)         (60)         (60)         (60)         (60)                      
      Lipoma                                                                     1 (2%)                                             
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)         (60)                      
   Intestine Small, Jejunum                           (59)         (60)         (60)         (60)         (60)                      
      Leiomyoma                                        1 (2%)                                                                       
   Intestine Small, Ileum                             (59)         (60)         (60)         (59)         (60)                      
      Leiomyosarcoma                                                             1 (2%)                                             
   Liver                                              (60)         (60)         (60)         (60)         (60)                      
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
      Carcinoma, Metastatic, Pancreas                                                                      1 (2%)                   
      Hepatocellular Carcinoma                                      1 (2%)                    1 (2%)                                
      Hepatocellular Adenoma                           2 (3%)       1 (2%)       1 (2%)                    4 (7%)                   
      Hepatocellular Adenoma, Multiple                                           1 (2%)                                             
   Mesentery                                          (11)         (15)         (15)         (17)         (6)                       
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (6%)                                
   Oral Mucosa                                                                  (1)          (2)                                    
      Squamous Cell Papilloma                                                    1 (100%)     2 (100%)                              
   Pancreas                                           (60)         (60)         (59)         (60)         (60)                      
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
      Acinus, Adenoma                                  3 (5%)                    2 (3%)       3 (5%)      10 (17%)                  
      Acinus, Carcinoma                                             1 (2%)                                 1 (2%)                   
   Salivary Glands                                    (60)         (60)         (60)         (60)         (60)                      

                                                             Page   7                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Schwannoma Malignant                                                                                 1 (2%)                   
   Stomach, Forestomach                               (60)         (60)         (60)         (60)         (60)                      
   Stomach, Glandular                                 (60)         (60)         (60)         (60)         (60)                      
      Carcinoma                                                                                            1 (2%)                   
   Tongue                                                                       (1)          (1)          (1)                       
      Squamous Cell Papilloma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)         (60)                      
      Thymoma Malignant, Metastatic, Thymus                                                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)         (60)                      
      Carcinoma                                                     1 (2%)                                                          
   Adrenal Medulla                                    (60)         (60)         (60)         (60)         (60)                      
      Pheochromocytoma Malignant                       2 (3%)       1 (2%)                    2 (3%)       2 (3%)                   
      Pheochromocytoma Benign                          7 (12%)      3 (5%)       8 (13%)     10 (17%)      8 (13%)                  
      Pheochromocytoma Benign, Multiple                3 (5%)                    2 (3%)                                             
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)         (60)                      
      Adenoma                                          5 (8%)       1 (2%)       2 (3%)       4 (7%)       1 (2%)                   
   Pituitary Gland                                    (59)         (60)         (60)         (60)         (59)                      
      Pars Distalis, Adenoma                          11 (19%)     10 (17%)     13 (22%)     11 (18%)     11 (19%)                  
      Pars Distalis, Adenoma, Multiple                 1 (2%)       1 (2%)                                                          
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                                      1 (2%)                    1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)         (60)                      
      C-Cell, Adenoma                                  5 (8%)       3 (5%)       3 (5%)       3 (5%)       2 (3%)                   
      Follicular Cell, Adenoma                                                   1 (2%)                    1 (2%)                   
      Follicular Cell, Carcinoma                                                                           2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)         (60)                      
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
   Preputial Gland                                    (60)         (60)         (60)         (60)         (60)                      
      Adenoma                                          4 (7%)       3 (5%)       3 (5%)       1 (2%)                                

                                                             Page   8                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Carcinoma                                        1 (2%)       3 (5%)       6 (10%)      1 (2%)                                
   Prostate                                           (60)         (60)         (60)         (60)         (60)                      
   Seminal Vesicle                                    (60)         (60)         (60)         (60)         (60)                      
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
   Testes                                             (60)         (60)         (60)         (60)         (60)                      
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
      Bilateral, Interstitial Cell, Adenoma           40 (67%)     45 (75%)     39 (65%)     42 (70%)     42 (70%)                  
      Interstitial Cell, Adenoma                      11 (18%)      9 (15%)     12 (20%)     15 (25%)     12 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)         (60)                      
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
   Lymph Node                                         (25)         (14)         (22)         (32)         (20)                      
      Iliac, Leiomyosarcoma, Metastatic, Intestine                                                                                  
          Large, Rectum                                1 (4%)                                                                       
      Mediastinal, Schwannoma Malignant,                                                                                            
          Metastatic, Skin                                          1 (7%)                                                          
   Lymph Node, Mandibular                             (59)         (58)         (59)         (60)         (60)                      
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (60)         (60)                      
   Lymph Node, Mediastinal                                                                   (1)                                    
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (100%)                              
   Spleen                                             (60)         (60)         (60)         (60)         (60)                      
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
      Fibroma                                                                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Liposarcoma                                                                1 (2%)                                             
   Thymus                                             (59)         (58)         (58)         (60)         (57)                      
      Thymoma Benign                                                             1 (2%)                    1 (2%)                   
      Thymoma Malignant                                                                                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (58)         (58)         (57)         (58)                      
      Carcinoma                                                                  1 (2%)                                             
      Fibroadenoma                                     2 (4%)       3 (5%)       5 (9%)       2 (4%)                                
   Skin                                               (60)         (60)         (60)         (60)         (60)                      
      Basal Cell Adenoma                                            2 (3%)                                 2 (3%)                   
      Basal Cell Carcinoma                             1 (2%)                                 1 (2%)       1 (2%)                   

                                                             Page   9                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  3 (5%)       1 (2%)       2 (3%)       2 (3%)       1 (2%)                   
      Squamous Cell Papilloma                          1 (2%)                                 1 (2%)       1 (2%)                   
      Sebaceous Gland, Adenoma                                                                1 (2%)                                
      Subcutaneous Tissue, Fibroma                     5 (8%)       1 (2%)       2 (3%)       5 (8%)       5 (8%)                   
      Subcutaneous Tissue, Lipoma                                                                          1 (2%)                   
      Subcutaneous Tissue, Melanoma Malignant          1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Benign                                     1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)       1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)         (60)                      
      Chordoma                                         1 (2%)                                                                       
      Osteoma                                                       1 (2%)                                                          
      Osteosarcoma                                                                                         1 (2%)                   
   Skeletal Muscle                                    (1)          (4)                       (1)                                    
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (100%)                              
      Carcinoma, Metastatic, Pancreas                               1 (25%)                                                         
      Fibrosarcoma                                                  1 (25%)                                                         
      Hemangiosarcoma                                  1 (100%)                                                                     
      Squamous Cell Carcinoma, Metastatic, Lung                     1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)         (60)                      
      Astrocytoma Malignant                                                      1 (2%)       1 (2%)                                
      Oligodendroglioma Malignant                      1 (2%)       2 (3%)                                                          
   Spinal Cord                                        (2)                       (1)                       (2)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)         (60)                      
      Alveolar/Bronchiolar Adenoma                                               2 (3%)                                             
      Alveolar/Bronchiolar Carcinoma                                2 (3%)       1 (2%)                    1 (2%)                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Thymoma Malignant, Metastatic, Thymus                                                                1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (2)                                                              
      Carcinoma                                                     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)         (60)                      
      Squamous Cell Carcinoma, Metastatic, Lung                     1 (2%)                                                          
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       2 (3%)                                             
      Renal Tubule, Carcinoma                                                                              1 (2%)                   
   Urinary Bladder                                    (60)         (60)         (60)         (60)         (60)                      
      Adenocarcinoma, Metastatic, Intestine Large,                                                                                  
           Colon                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)        *(60)                      
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            31 (52%)     15 (25%)     29 (48%)     35 (58%)     30 (50%)                  
      Mesothelioma Malignant                           1 (2%)       1 (2%)       3 (5%)       3 (5%)       1 (2%)                   
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05094-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/03/96  
Route: DOSED FEED                                                                                                 Time: 06:46:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     CONTROL      0.3%         0.6%         1.2%                         
                                                   CONTROL      FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            58          60          57          59          59                           
     Total Primary Neoplasms                          147         118         150         149         147                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 54          57          56          58          56                           
     Total Benign Neoplasms                           105          86         105         104         102                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38          28          36          41          38                           
     Total Malignant Neoplasms                         42          32          45          45          45                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4                       2           2                           
     Total Metastatic Neoplasm                          2           7                      12           3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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