TDMS Study 05096-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
O-CHLOROBENZALMALONONITRILE (CS-2)
NTP Experiment-Test: 05096-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
Facility: Battelle Northwest
Chemical CAS #: 2698-41-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 9 5 7
Moribund 8 5 3
Survivors
Terminal Sacrifice 33 40 40
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (42) (5) (40)
Inflammation, Suppurative 1 (3%)
Intestine Small, Ileum (44) (9) (44)
Amyloid Deposition 1 (2%)
Liver (50) (15) (49)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Leukocytosis 2 (4%) 1 (2%)
Necrosis 3 (6%) 1 (7%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Mesentery (4) (1)
Fibrosis 1 (25%)
Inflammation, Chronic 1 (100%)
Necrosis 2 (50%) 1 (100%)
Pancreas (50) (11) (49)
Atrophy 1 (2%)
Developmental Malformation 1 (9%)
Inflammation, Chronic 1 (9%)
Duct, Dilatation 1 (2%)
Stomach, Forestomach (48) (48) (47)
Acanthosis 3 (6%)
Cyst 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (49) (48) (47)
Erosion 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Epithelium, Hyperplasia 2 (4%) 3 (6%)
Tooth (1)
Developmental Malformation 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (49)
Cardiomyopathy 1 (2%)
Hemorrhage 2 (4%)
Inflammation, Suppurative 1 (2%)
Artery, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (10) (49)
Capsule, Hyperplasia 49 (98%) 9 (90%) 48 (98%)
Adrenal Gland, Cortex (50) (10) (49)
Angiectasis 1 (2%) 1 (2%)
Cyst 1 (2%)
Cytomegaly 4 (8%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Gland, Medulla (49) (10) (48)
Inflammation, Suppurative 1 (2%)
Karyomegaly 1 (2%)
Parathyroid Gland (14) (5) (36)
Cyst 1 (3%)
Pituitary Gland (47) (46) (46)
Angiectasis 6 (13%)
Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 16 (34%) 8 (17%) 7 (15%)
Thyroid Gland (49) (49) (49)
Inflammation, Suppurative 2 (4%) 1 (2%) 2 (4%)
C-Cell, Hyperplasia 1 (2%)
Follicular Cell, Hyperplasia 17 (35%) 6 (12%) 5 (10%)
Follicular Cell, Hyperplasia, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Inflammation, Suppurative 1 (100%)
Ovary (50) (20) (49)
Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 15 (30%) 10 (50%) 10 (20%)
Cyst, Multiple 1 (2%) 1 (5%)
Hemorrhage 4 (8%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Germinal Epithelium, Hyperplasia 3 (6%) 2 (4%)
Uterus (49) (15) (48)
Angiectasis 1 (2%)
Dilatation 2 (4%) 2 (13%) 8 (17%)
Hemorrhage 1 (2%) 1 (7%) 3 (6%)
Inflammation, Suppurative 3 (6%)
Thrombosis 1 (7%)
Endometrium, Hyperplasia 30 (61%) 5 (33%) 23 (48%)
Endometrium, Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (49)
Myelofibrosis 36 (72%) 5 (50%) 42 (86%)
Myeloid Cell, Hyperplasia 2 (4%)
Lymph Node (50) (15) (48)
Hyperplasia, Lymphoid 1 (7%)
Mesenteric, Hematopoietic Cell Proliferation 1 (7%)
Pancreatic, Angiectasis 1 (2%)
Pancreatic, Inflammation, Suppurative 1 (2%)
Lymph Node, Bronchial (48) (11) (46)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%)
Pigmentation 1 (2%)
Lymph Node, Mandibular (44) (11) (38)
Cyst 1 (3%)
Hematopoietic Cell Proliferation 5 (11%) 4 (11%)
Hyperplasia, Lymphoid 1 (3%)
Inflammation, Suppurative 1 (3%)
Spleen (50) (19) (49)
Hematopoietic Cell Proliferation 9 (18%) 7 (37%) 10 (20%)
Infarct 2 (4%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (10) (47)
Cyst 1 (2%)
Skin (50) (17) (49)
Acanthosis 2 (4%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Suppurative 1 (2%)
Ulcer 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (49)
Compression 5 (10%) 1 (2%)
Hemorrhage 2 (4%) 2 (4%)
Mineralization 20 (40%) 5 (45%) 17 (35%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (10) (47)
Artery, Inflammation 1 (2%)
Lung (50) (17) (49)
Congestion 2 (4%)
Hemorrhage 1 (2%) 2 (4%)
Leukocytosis 4 (8%) 4 (8%)
Alveolus, Hyperplasia 3 (6%) 1 (6%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 5 (10%) 2 (12%) 5 (10%)
Alveolus, Inflammation, Suppurative 2 (4%) 2 (4%)
Artery, Mineralization 1 (2%)
Pleura, Fibrosis 1 (2%)
Nose (50) (49) (49)
Exudate, Serous 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%) 2 (4%)
Inflammation, Suppurative 8 (16%) 9 (18%) 18 (37%)
Nasolacrimal Duct, Inflammation, Suppurative 7 (14%) 2 (4%)
Olfactory Epithelium, Atrophy 1 (2%)
Respiratory Epithelium, Hyperplasia 4 (8%) 7 (14%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 6 (12%) 17 (35%)
Trachea (50) (10) (48)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (33) (38)
Atrophy 1 (3%)
Hemorrhage 1 (3%)
Cornea, Inflammation, Suppurative 1 (3%)
Lens, Cataract 1 (3%)
Retina, Vacuolization Cytoplasmic 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (13) (49)
Developmental Malformation 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 1 (2%) 1 (2%)
Nephropathy, Chronic 41 (84%) 7 (54%) 47 (96%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 7 4 5
Moribund 5 4 5
Survivors
Terminal Sacrifice 38 42 40
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (39) (5) (40)
Infarct 1 (3%)
Necrosis 1 (3%)
Intestine Large, Rectum (47) (5) (48)
Hemorrhage 1 (2%)
Intestine Small, Duodenum (44) (5) (44)
Developmental Malformation 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Suppurative 1 (2%)
Intestine Small, Ileum (43) (3) (44)
Hyperplasia, Lymphoid 1 (2%)
Liver (49) (19) (50)
Angiectasis 1 (2%) 1 (2%)
Clear Cell Focus 2 (4%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (5%)
Hepatodiaphragmatic Nodule 1 (2%)
Hyperplasia 2 (4%) 3 (16%) 2 (4%)
Infarct 2 (4%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Leukocytosis 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
Mesentery (1) (1)
Artery, Thrombosis 1 (100%)
Pancreas (49) (7) (50)
Acinar Cell, Hypertrophy 1 (2%)
Stomach, Forestomach (47) (45) (49)
Acanthosis 2 (4%)
Inflammation, Suppurative 1 (2%)
Stomach, Glandular (49) (49) (48)
Erosion 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (8) (50)
Cardiomyopathy 1 (2%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (7) (49)
Capsule, Hyperplasia 41 (84%) 4 (57%) 34 (69%)
Adrenal Gland, Cortex (49) (7) (49)
Cyst 1 (2%)
Cytomegaly 10 (20%) 6 (12%)
Hyperplasia 1 (2%)
Adrenal Gland, Medulla (49) (7) (49)
Karyomegaly 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Parathyroid Gland (20) (1) (24)
Cyst 1 (4%)
Pituitary Gland (46) (7) (46)
Cyst 1 (2%)
Thyroid Gland (48) (7) (50)
Cyst 1 (2%)
Inflammation, Suppurative 1 (2%)
Follicular Cell, Hyperplasia 4 (8%) 2 (29%) 6 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (46) (7) (49)
Inflammation, Suppurative 1 (2%)
Penis (5) (1) (1)
Concretion 2 (40%)
Inflammation, Suppurative 4 (80%) 1 (100%) 1 (100%)
Necrosis 1 (100%)
Preputial Gland (4) (5) (4)
Cyst 2 (50%) 3 (60%) 1 (25%)
Hyperplasia 1 (20%)
Inflammation, Chronic 1 (25%) 1 (20%)
Inflammation, Suppurative 1 (25%) 3 (60%) 3 (75%)
Prostate (48) (7) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Suppurative 4 (8%) 1 (14%) 2 (4%)
Seminal Vesicle (47) (9) (49)
Dilatation 1 (2%) 1 (11%) 2 (4%)
Inflammation, Suppurative 3 (6%) 1 (11%) 2 (4%)
Testes (48) (7) (50)
Atrophy 9 (19%) 2 (29%) 5 (10%)
Inflammation, Suppurative 1 (14%)
Mineralization 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (7) (50)
Hyperplasia 1 (14%)
Myelofibrosis 2 (4%)
Lymph Node (48) (9) (47)
Inguinal, Hematopoietic Cell Proliferation 1 (2%)
Mesenteric, Angiectasis 1 (2%)
Mesenteric, Hematopoietic Cell Proliferation 2 (22%)
Spleen (49) (8) (50)
Atrophy 2 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 2 (25%) 6 (12%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (13) (50)
Acanthosis 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 4 (8%) 3 (23%) 6 (12%)
Ulcer 2 (4%) 1 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (7) (50)
Mineralization 17 (35%) 1 (14%) 16 (32%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (7) (50)
Inflammation, Suppurative 1 (2%)
Lung (49) (49) (50)
Hemorrhage 1 (2%)
Inflammation, Granulomatous 1 (2%)
Leukocytosis 2 (4%) 1 (2%) 2 (4%)
Alveolus, Hyperplasia 6 (12%) 3 (6%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 4 (8%)
Alveolus, Inflammation, Suppurative 1 (2%)
Nose (50) (47) (50)
Foreign Body 1 (2%) 1 (2%)
Inflammation, Suppurative 3 (6%) 16 (34%) 23 (46%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 1 (2%)
Olfactory Epithelium, Atrophy 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 8 (17%) 12 (24%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 12 (26%) 24 (48%)
Trachea (49) (7) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (41) (43)
Cornea, Inflammation, Suppurative 1 (2%)
Retina, Vacuolization Cytoplasmic 3 (7%) 5 (12%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50)
Cyst 4 (8%)
Infiltration Cellular, Diffuse,
Polymorphonuclear 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (4%)
Nephropathy, Chronic 43 (88%) 40 (82%) 47 (94%)
Artery, Inflammation 1 (2%)
Pelvis, Inflammation, Suppurative 4 (8%) 2 (4%) 1 (2%)
Urinary Bladder (48) (7) (49)
Dilatation 1 (14%)
Hemorrhage 1 (2%)
Hyperplasia 3 (6%) 2 (29%) 3 (6%)
Inflammation, Suppurative 5 (10%) 2 (29%) 3 (6%)
Metaplasia, Squamous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05096-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:17:36
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.75 MG/ 1.5 MG/
M3 M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Ulcer 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 67513-67513/67513
--multipart-boundary--