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https://ntp.niehs.nih.gov/go/1168

TDMS Study 05096-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 O-CHLOROBENZALMALONONITRILE (CS-2)


NTP Experiment-Test: 05096-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36




       Facility:  Battelle Northwest

       Chemical CAS #:  2698-41-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            5            7                                                  
    Moribund                                           8            5            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           40           40                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (5)          (40)                                                
      Inflammation, Suppurative                                                  1 (3%)                                             
   Intestine Small, Ileum                             (44)         (9)          (44)                                                
      Amyloid Deposition                               1 (2%)                                                                       
   Liver                                              (50)         (15)         (49)                                                
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                 1 (2%)                                                                       
      Clear Cell Focus                                                           1 (2%)                                             
      Eosinophilic Focus                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)                                                                       
      Leukocytosis                                     2 (4%)                    1 (2%)                                             
      Necrosis                                         3 (6%)       1 (7%)       1 (2%)                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Mesentery                                          (4)          (1)                                                              
      Fibrosis                                         1 (25%)                                                                      
      Inflammation, Chronic                                         1 (100%)                                                        
      Necrosis                                         2 (50%)      1 (100%)                                                        
   Pancreas                                           (50)         (11)         (49)                                                
      Atrophy                                          1 (2%)                                                                       
      Developmental Malformation                                    1 (9%)                                                          
      Inflammation, Chronic                                         1 (9%)                                                          
      Duct, Dilatation                                 1 (2%)                                                                       
   Stomach, Forestomach                               (48)         (48)         (47)                                                
      Acanthosis                                                    3 (6%)                                                          
      Cyst                                                          1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (49)         (48)         (47)                                                
      Erosion                                                       2 (4%)       1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia                          2 (4%)                    3 (6%)                                             
   Tooth                                                           (1)                                                              
      Developmental Malformation                                    1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (49)                                                
      Cardiomyopathy                                   1 (2%)                                                                       
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (10)         (49)                                                
      Capsule, Hyperplasia                            49 (98%)      9 (90%)     48 (98%)                                            
   Adrenal Gland, Cortex                              (50)         (10)         (49)                                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Cyst                                                                       1 (2%)                                             
      Cytomegaly                                       4 (8%)                    3 (6%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (10)         (48)                                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Karyomegaly                                      1 (2%)                                                                       
   Parathyroid Gland                                  (14)         (5)          (36)                                                
      Cyst                                                                       1 (3%)                                             
   Pituitary Gland                                    (47)         (46)         (46)                                                
      Angiectasis                                      6 (13%)                                                                      
      Cyst                                             1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                      16 (34%)      8 (17%)      7 (15%)                                            
   Thyroid Gland                                      (49)         (49)         (49)                                                
      Inflammation, Suppurative                        2 (4%)       1 (2%)       2 (4%)                                             
      C-Cell, Hyperplasia                              1 (2%)                                                                       
      Follicular Cell, Hyperplasia                    17 (35%)      6 (12%)      5 (10%)                                            
      Follicular Cell, Hyperplasia, Multiple                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
   Ovary                                              (50)         (20)         (49)                                                
      Angiectasis                                                                1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                            15 (30%)     10 (50%)     10 (20%)                                            
      Cyst, Multiple                                   1 (2%)       1 (5%)                                                          
      Hemorrhage                                                                 4 (8%)                                             
      Mineralization                                                             1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Germinal Epithelium, Hyperplasia                 3 (6%)                    2 (4%)                                             
   Uterus                                             (49)         (15)         (48)                                                
      Angiectasis                                      1 (2%)                                                                       
      Dilatation                                       2 (4%)       2 (13%)      8 (17%)                                            
      Hemorrhage                                       1 (2%)       1 (7%)       3 (6%)                                             
      Inflammation, Suppurative                                                  3 (6%)                                             
      Thrombosis                                                    1 (7%)                                                          
      Endometrium, Hyperplasia                        30 (61%)      5 (33%)     23 (48%)                                            
      Endometrium, Metaplasia, Squamous                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (49)                                                
      Myelofibrosis                                   36 (72%)      5 (50%)     42 (86%)                                            
      Myeloid Cell, Hyperplasia                                                  2 (4%)                                             
   Lymph Node                                         (50)         (15)         (48)                                                
      Hyperplasia, Lymphoid                                         1 (7%)                                                          
      Mesenteric, Hematopoietic Cell Proliferation                  1 (7%)                                                          
      Pancreatic, Angiectasis                                                    1 (2%)                                             
      Pancreatic, Inflammation, Suppurative                                      1 (2%)                                             
   Lymph Node, Bronchial                              (48)         (11)         (46)                                                
      Hematopoietic Cell Proliferation                 3 (6%)                    1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
   Lymph Node, Mandibular                             (44)         (11)         (38)                                                
      Cyst                                                                       1 (3%)                                             
      Hematopoietic Cell Proliferation                 5 (11%)                   4 (11%)                                            
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
      Inflammation, Suppurative                                                  1 (3%)                                             
   Spleen                                             (50)         (19)         (49)                                                
      Hematopoietic Cell Proliferation                 9 (18%)      7 (37%)     10 (20%)                                            
      Infarct                                          2 (4%)                                                                       
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (10)         (47)                                                
      Cyst                                             1 (2%)                                                                       
   Skin                                               (50)         (17)         (49)                                                
      Acanthosis                                                                 2 (4%)                                             
      Hemorrhage                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer                                                                      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (49)                                                
      Compression                                      5 (10%)                   1 (2%)                                             
      Hemorrhage                                       2 (4%)                    2 (4%)                                             
      Mineralization                                  20 (40%)      5 (45%)     17 (35%)                                            
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (10)         (47)                                                
      Artery, Inflammation                                                       1 (2%)                                             
   Lung                                               (50)         (17)         (49)                                                
      Congestion                                                                 2 (4%)                                             
      Hemorrhage                                       1 (2%)                    2 (4%)                                             
      Leukocytosis                                     4 (8%)                    4 (8%)                                             
      Alveolus, Hyperplasia                            3 (6%)       1 (6%)       1 (2%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      5 (10%)      2 (12%)      5 (10%)                                            
      Alveolus, Inflammation, Suppurative              2 (4%)                    2 (4%)                                             
      Artery, Mineralization                                                     1 (2%)                                             
      Pleura, Fibrosis                                 1 (2%)                                                                       
   Nose                                               (50)         (49)         (49)                                                
      Exudate, Serous                                               1 (2%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       2 (4%)       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                    2 (4%)                                             
      Inflammation, Suppurative                        8 (16%)      9 (18%)     18 (37%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative     7 (14%)      2 (4%)                                                          
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                           4 (8%)       7 (14%)                                            
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       6 (12%)     17 (35%)                                            
   Trachea                                            (50)         (10)         (48)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (33)                      (38)                                                
      Atrophy                                                                    1 (3%)                                             
      Hemorrhage                                                                 1 (3%)                                             
      Cornea, Inflammation, Suppurative                1 (3%)                                                                       
      Lens, Cataract                                                             1 (3%)                                             
      Retina, Vacuolization Cytoplasmic                                          1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (13)         (49)                                                
      Developmental Malformation                                                 1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Nephropathy, Chronic                            41 (84%)      7 (54%)     47 (96%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7            4            5                                                  
    Moribund                                           5            4            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           42           40                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (5)          (40)                                                
      Infarct                                          1 (3%)                                                                       
      Necrosis                                         1 (3%)                                                                       
   Intestine Large, Rectum                            (47)         (5)          (48)                                                
      Hemorrhage                                       1 (2%)                                                                       
   Intestine Small, Duodenum                          (44)         (5)          (44)                                                
      Developmental Malformation                                                 1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
   Intestine Small, Ileum                             (43)         (3)          (44)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (49)         (19)         (50)                                                
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Clear Cell Focus                                 2 (4%)                                                                       
      Eosinophilic Focus                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       1 (5%)                                                          
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Hyperplasia                                      2 (4%)       3 (16%)      2 (4%)                                             
      Infarct                                          2 (4%)                    1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
      Leukocytosis                                     1 (2%)                    1 (2%)                                             
      Necrosis                                         2 (4%)                    1 (2%)                                             
   Mesentery                                                       (1)          (1)                                                 
      Artery, Thrombosis                                            1 (100%)                                                        
   Pancreas                                           (49)         (7)          (50)                                                
      Acinar Cell, Hypertrophy                         1 (2%)                                                                       
   Stomach, Forestomach                               (47)         (45)         (49)                                                
      Acanthosis                                       2 (4%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
   Stomach, Glandular                                 (49)         (49)         (48)                                                
      Erosion                                          2 (4%)       1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (8)          (50)                                                
      Cardiomyopathy                                   1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (7)          (49)                                                
      Capsule, Hyperplasia                            41 (84%)      4 (57%)     34 (69%)                                            
   Adrenal Gland, Cortex                              (49)         (7)          (49)                                                
      Cyst                                             1 (2%)                                                                       
      Cytomegaly                                      10 (20%)                   6 (12%)                                            
      Hyperplasia                                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (7)          (49)                                                
      Karyomegaly                                                                1 (2%)                                             
      Vacuolization Cytoplasmic                                                  1 (2%)                                             
   Parathyroid Gland                                  (20)         (1)          (24)                                                
      Cyst                                                                       1 (4%)                                             
   Pituitary Gland                                    (46)         (7)          (46)                                                
      Cyst                                                                       1 (2%)                                             
   Thyroid Gland                                      (48)         (7)          (50)                                                
      Cyst                                                                       1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Follicular Cell, Hyperplasia                     4 (8%)       2 (29%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (46)         (7)          (49)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Penis                                              (5)          (1)          (1)                                                 
      Concretion                                       2 (40%)                                                                      
      Inflammation, Suppurative                        4 (80%)      1 (100%)     1 (100%)                                           
      Necrosis                                                      1 (100%)                                                        
   Preputial Gland                                    (4)          (5)          (4)                                                 
      Cyst                                             2 (50%)      3 (60%)      1 (25%)                                            
      Hyperplasia                                                   1 (20%)                                                         
      Inflammation, Chronic                            1 (25%)      1 (20%)                                                         
      Inflammation, Suppurative                        1 (25%)      3 (60%)      3 (75%)                                            
   Prostate                                           (48)         (7)          (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Suppurative                        4 (8%)       1 (14%)      2 (4%)                                             
   Seminal Vesicle                                    (47)         (9)          (49)                                                
      Dilatation                                       1 (2%)       1 (11%)      2 (4%)                                             
      Inflammation, Suppurative                        3 (6%)       1 (11%)      2 (4%)                                             
   Testes                                             (48)         (7)          (50)                                                
      Atrophy                                          9 (19%)      2 (29%)      5 (10%)                                            
      Inflammation, Suppurative                                     1 (14%)                                                         
      Mineralization                                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (7)          (50)                                                
      Hyperplasia                                                   1 (14%)                                                         
      Myelofibrosis                                    2 (4%)                                                                       
   Lymph Node                                         (48)         (9)          (47)                                                
      Inguinal, Hematopoietic Cell Proliferation       1 (2%)                                                                       
      Mesenteric, Angiectasis                          1 (2%)                                                                       
      Mesenteric, Hematopoietic Cell Proliferation                  2 (22%)                                                         
   Spleen                                             (49)         (8)          (50)                                                
      Atrophy                                          2 (4%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 3 (6%)       2 (25%)      6 (12%)                                            
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (13)         (50)                                                
      Acanthosis                                       1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                        4 (8%)       3 (23%)      6 (12%)                                            
      Ulcer                                            2 (4%)       1 (8%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                                                                           
      Hemorrhage                                       1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (7)          (50)                                                
      Mineralization                                  17 (35%)      1 (14%)     16 (32%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (7)          (50)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Lung                                               (49)         (49)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Leukocytosis                                     2 (4%)       1 (2%)       2 (4%)                                             
      Alveolus, Hyperplasia                            6 (12%)      3 (6%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       1 (2%)       4 (8%)                                             
      Alveolus, Inflammation, Suppurative              1 (2%)                                                                       
   Nose                                               (50)         (47)         (50)                                                
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        3 (6%)      16 (34%)     23 (46%)                                            
      Nasolacrimal Duct, Inflammation, Suppurative     2 (4%)       1 (2%)                                                          
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              1 (2%)       8 (17%)     12 (24%)                                            
      Respiratory Epithelium, Metaplasia, Squamous     2 (4%)      12 (26%)     24 (48%)                                            
   Trachea                                            (49)         (7)          (50)                                                
      Inflammation, Suppurative                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (41)                      (43)                                                
      Cornea, Inflammation, Suppurative                1 (2%)                                                                       
      Retina, Vacuolization Cytoplasmic                3 (7%)                    5 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)                                                
      Cyst                                                                       4 (8%)                                             
      Infiltration Cellular, Diffuse,                                                                                               
          Polymorphonuclear                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                                             2 (4%)                                             
      Nephropathy, Chronic                            43 (88%)     40 (82%)     47 (94%)                                            
      Artery, Inflammation                                                       1 (2%)                                             
      Pelvis, Inflammation, Suppurative                4 (8%)       2 (4%)       1 (2%)                                             
   Urinary Bladder                                    (48)         (7)          (49)                                                
      Dilatation                                                    1 (14%)                                                         
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      3 (6%)       2 (29%)      3 (6%)                                             
      Inflammation, Suppurative                        5 (10%)      2 (29%)      3 (6%)                                             
      Metaplasia, Squamous                             1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05096-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:36  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Ulcer                                            1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
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                             ----------              END OF REPORT             ----------                                           
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