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TDMS Study 05096-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 O-CHLOROBENZALMALONONITRILE (CS-2)


NTP Experiment-Test: 05096-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37




       Facility:  Battelle Northwest

       Chemical CAS #:  2698-41-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            5            7                                                  
    Moribund                                           8            5            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           40           40                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (10)         (47)                                                
   Gallbladder                                        (42)         (5)          (40)                                                
   Intestine Large, Cecum                             (44)         (7)          (43)                                                
      Leiomyosarcoma                                                1 (14%)                                                         
   Intestine Large, Colon                             (46)         (9)          (44)                                                
   Intestine Large, Rectum                            (47)         (9)          (45)                                                
   Intestine Small, Duodenum                          (43)         (7)          (44)                                                
   Intestine Small, Ileum                             (44)         (9)          (44)                                                
   Intestine Small, Jejunum                           (43)         (9)          (43)                                                
   Liver                                              (50)         (15)         (49)                                                
      Hepatocellular Carcinoma                         7 (14%)      1 (7%)       4 (8%)                                             
      Hepatocellular Carcinoma, Multiple                            1 (7%)       2 (4%)                                             
      Hepatocellular Adenoma                           4 (8%)       2 (13%)      3 (6%)                                             
   Mesentery                                          (4)          (1)                                                              
   Pancreas                                           (50)         (11)         (49)                                                
   Salivary Glands                                    (50)         (10)         (49)                                                
   Stomach, Forestomach                               (48)         (48)         (47)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          2 (4%)       4 (8%)                                                          
   Stomach, Glandular                                 (49)         (48)         (47)                                                
      Adenoma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (10)         (49)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (10)         (48)                                                
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (50)         (9)          (48)                                                
   Pituitary Gland                                    (47)         (46)         (46)                                                
      Pars Distalis, Adenoma                          13 (28%)      5 (11%)      1 (2%)                                             
      Pars Intermedia, Adenoma                                                   3 (7%)                                             
   Thyroid Gland                                      (49)         (49)         (49)                                                
      Follicular Cell, Adenoma                         2 (4%)       2 (4%)       2 (4%)                                             
      Follicular Cell, Adenoma, Multiple                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (20)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
      Hemangioma                                                    1 (5%)                                                          
      Teratoma                                         1 (2%)                    1 (2%)                                             
      Teratoma Malignant                                            1 (5%)                                                          
   Uterus                                             (49)         (15)         (48)                                                
      Hemangioma                                       1 (2%)       1 (7%)       1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyoma                                        1 (2%)                                                                       
      Polyp, Adenoid                                   1 (2%)                                                                       
      Polyp Stromal                                    2 (4%)       1 (7%)                                                          
      Sarcoma Stromal                                               1 (7%)                                                          
   Vagina                                                                       (1)                                                 
      Polyp                                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (49)                                                
   Lymph Node                                         (50)         (15)         (48)                                                
      Teratoma NOS, Metastatic, Ovary                               1 (7%)                                                          
      Pancreatic, Sarcoma                              1 (2%)                                                                       
   Lymph Node, Bronchial                              (48)         (11)         (46)                                                
   Lymph Node, Mandibular                             (44)         (11)         (38)                                                
      Squamous Cell Carcinoma, Metastatic, Skin        1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (19)         (49)                                                
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (46)         (10)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (10)         (47)                                                
      Adenocarcinoma                                   3 (7%)       1 (10%)                                                         
   Skin                                               (50)         (17)         (49)                                                
      Fibrosarcoma                                     1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Papilloma                                        1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (12)         (49)                                                
      Cranium, Osteosarcoma                                         1 (8%)       1 (2%)                                             
      Vertebra, Osteosarcoma                           1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (10)         (47)                                                
   Lung                                               (50)         (17)         (49)                                                
      Adenocarcinoma, Metastatic, Harderian Gland      2 (4%)                    1 (2%)                                             
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     4 (8%)       2 (12%)      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (2%)                                             
      Carcinoma, Metastatic, Liver                     2 (4%)                                                                       
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Uterus              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin        1 (2%)                                                                       
      Bronchus, Alveolus, Adenoma                                   1 (6%)                                                          
      Mediastinum, Hemangioma                                       1 (6%)                                                          
   Nose                                               (50)         (49)         (49)                                                
      Adenocarcinoma, Metastatic, Harderian Gland      1 (2%)                                                                       
   Trachea                                            (50)         (10)         (48)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (2)          (1)                                                 
      Adenocarcinoma                                   2 (50%)                   1 (100%)                                           
      Adenoma                                          2 (50%)      2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (13)         (49)                                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Urinary Bladder                                    (48)         (8)          (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lymphoma Malignant                               2 (4%)                                                                       
      Lymphoma Malignant Histiocytic                   2 (4%)       3 (6%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         6 (12%)      9 (18%)      4 (8%)                                             
      Lymphoma Malignant Undifferentiated Cell        11 (22%)      1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          27          27                                                   
     Total Primary Neoplasms                           80          43          33                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          17          13                                                   
     Total Benign Neoplasms                            37          23          15                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          17          16                                                   
     Total Malignant Neoplasms                         43          20          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9           1           1                                                   
     Total Metastatic Neoplasm                         12           1           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7            4            5                                                  
    Moribund                                           5            4            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           42           40                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (5)          (40)                                                
   Intestine Small, Duodenum                          (44)         (5)          (44)                                                
      Polyp Adenomatous                                             1 (20%)                                                         
   Intestine Small, Ileum                             (43)         (3)          (44)                                                
   Intestine Small, Jejunum                           (44)         (2)          (47)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (49)         (19)         (50)                                                
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Hemangioma                                       1 (2%)                                                                       
      Hemangioma, Multiple                                                       1 (2%)                                             
      Hemangiosarcoma, Multiple                                                  1 (2%)                                             
      Hepatocellular Carcinoma                        11 (22%)      5 (26%)      5 (10%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)       2 (11%)      3 (6%)                                             
      Hepatocellular Adenoma                           3 (6%)       8 (42%)      5 (10%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                                       (1)          (1)                                                 
      Sarcoma, Metastatic, Stomach                                               1 (100%)                                           
   Pancreas                                           (49)         (7)          (50)                                                
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
   Salivary Glands                                    (49)         (7)          (50)                                                
   Stomach, Forestomach                               (47)         (45)         (49)                                                
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (49)         (48)                                                
      Sarcoma, Metastatic, Stomach                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (8)          (50)                                                
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (7)          (49)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (7)          (49)                                                
   Pituitary Gland                                    (46)         (7)          (46)                                                
      Pars Distalis, Adenoma                                        1 (14%)                                                         
   Thyroid Gland                                      (48)         (7)          (50)                                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (46)         (7)          (49)                                                
   Prostate                                           (48)         (7)          (49)                                                
   Seminal Vesicle                                    (47)         (9)          (49)                                                
   Testes                                             (48)         (7)          (50)                                                
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (7)          (50)                                                
   Lymph Node                                         (48)         (9)          (47)                                                
      Mediastinal, Adenocarcinoma, Metastatic, Lung                 1 (11%)                                                         
   Lymph Node, Bronchial                              (47)         (5)          (43)                                                
      Carcinoma, Metastatic, Lung                      2 (4%)                                                                       
   Lymph Node, Mandibular                             (42)         (4)          (35)                                                
   Spleen                                             (49)         (8)          (50)                                                
      Hemangiosarcoma                                                            2 (4%)                                             
   Thymus                                             (38)         (5)          (43)                                                
      Carcinoma, Metastatic, Lung                      1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (13)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (8)          (50)                                                
      Cranium, Adenocarcinoma, Metastatic, Lung                     1 (13%)                                                         
      Rib, Carcinoma, Metastatic, Lung                              1 (13%)                                                         
   Skeletal Muscle                                    (2)                                                                           
      Diaphragm, Carcinoma, Metastatic, Lung           1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (49)         (50)                                                
      Adenocarcinoma                                                1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     7 (14%)      7 (14%)      9 (18%)                                            
      Alveolar/Bronchiolar Carcinoma                   5 (10%)      1 (2%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      4 (8%)       2 (4%)       1 (2%)                                             
   Nose                                               (50)         (47)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (6)          (2)          (2)                                                 
      Adenoma                                          6 (100%)     2 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)                                                
      Adenocarcinoma, Metastatic, Lung                              1 (2%)                                                          
      Carcinoma, Metastatic, Liver                                               1 (2%)                                             
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
   Urinary Bladder                                    (48)         (7)          (49)                                                
                                                             Page   9                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Mixed                         1 (2%)       3 (6%)       1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05096-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 05:17:37  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      0.75 MG/     1.5 MG/                                                
                                                                M3           M3                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            31          24          30                                                   
     Total Primary Neoplasms                           46          31          37                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 18          17          17                                                   
     Total Benign Neoplasms                            20          19          20                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          11          15                                                   
     Total Malignant Neoplasms                         26          12          17                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           3           3                                                   
     Total Metastatic Neoplasm                         12           6           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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