TDMS Study 05096-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest O-CHLOROBENZALMALONONITRILE (CS-2) DATE: 09/13/94
EXPERIMENT: 05096 TEST: 02 TIME: 05:26:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55118
PATHOLOGIST: R. RENNE S. EUSTIS CAS: 2698-41-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest O-CHLOROBENZALMALONONITRILE (CS-2) DATE: 09/13/94
EXPERIMENT: 05096 TEST: 02 TIME: 05:26:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55118
PATHOLOGIST: R. RENNE S. EUSTIS CAS: 2698-41-1
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest O-CHLOROBENZALMALONONITRILE (CS-2) DATE: 09/13/94
EXPERIMENT: 05096 TEST: 02 TIME: 05:26:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55118
PATHOLOGIST: R. RENNE S. EUSTIS CAS: 2698-41-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF O-CHLOROBENZALMALONONITRILE (CS-2)
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Malignant Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Pituitary Gland: Pars Intermedia
Adenoma
Uterus Polyp Stromal
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/7 (0%) 0/49 (0%) | 2/49 (4%) 0/10 (0%) 0/48 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.1% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/0 0/39 (0%) | 2/33 (6%) 0/1 (0%) 0/39 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 748 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.116N P=0.970N P=0.202N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.116N P=0.970N P=0.202N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.116N P=0.970N P=0.202N |
|COCHRAN-ARMITAGE | (e) | P=0.133N |
|FISHER EXACT | (e) (e) | P=0.687N P=0.253N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 2/50 (4%) | 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 14.6% 4.8% 5.0% | 6.1% 5.0% 0.0% |
|TERMINAL (d) | 4/38 (11%) 2/42 (5%) 2/40 (5%) | 2/33 (6%) 2/40 (5%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 609 749 (T) 749 (T) | 748 (T) 748 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.074N P=0.116N P=0.129N | P=0.134N P=0.624N P=0.197N |
|INCIDENTAL TUMOR | P=0.073N P=0.111N P=0.113N | P=0.134N P=0.624N P=0.197N |
|LOGISTIC REGRESSION | P=0.080N P=0.129N P=0.134N | P=0.134N P=0.624N P=0.197N |
|COCHRAN-ARMITAGE | P=0.080N | P=0.176N |
|FISHER EXACT | P=0.134N P=0.134N | P=0.691N P=0.247N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 5.3% 0.0% 2.5% |
|TERMINAL (d) | 0/38 (0%) 0/42 (0%) 0/40 (0%) | 1/33 (3%) 0/40 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 679 --- 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.317N P=0.209N P=0.443N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.361N P=0.256N P=0.496N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.352N P=0.236N P=0.488N |
|COCHRAN-ARMITAGE | (e) | P=0.360N |
|FISHER EXACT | (e) (e) | P=0.247N P=0.500N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 2/50 (4%) | 4/50 (8%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 14.6% 4.8% 5.0% | 11.3% 5.0% 2.5% |
|TERMINAL (d) | 4/38 (11%) 2/42 (5%) 2/40 (5%) | 3/33 (9%) 2/40 (5%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 609 749 (T) 749 (T) | 679 748 (T) 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.074N P=0.116N P=0.129N | P=0.081N P=0.261N P=0.133N |
|INCIDENTAL TUMOR | P=0.073N P=0.111N P=0.113N | P=0.095N P=0.292N P=0.156N |
|LOGISTIC REGRESSION | P=0.080N P=0.129N P=0.134N | P=0.098N P=0.301N P=0.156N |
|COCHRAN-ARMITAGE | P=0.080N | P=0.118N |
|FISHER EXACT | P=0.134N P=0.134N | P=0.339N P=0.181N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 8/19 (42%) 5/50 (10%) | 4/50 (8%) 2/15 (13%) 3/49 (6%) |
|ADJUSTED (b) | 10.5% 59.3% 12.0% | 11.8% 33.3% 7.0% |
|TERMINAL (d) | 4/38 (11%) 7/12 (58%) 4/40 (10%) | 3/33 (9%) 2/6 (33%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 657 599 | 740 748 (T) 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.478 P<0.001 ** P=0.525 | P=0.323N P=0.417 P=0.400N |
|INCIDENTAL TUMOR | P=0.476 P<0.001 ** P=0.598 | P=0.389N P=0.347 P=0.503N |
|LOGISTIC REGRESSION | P=0.440 P<0.001 ** P=0.501 | P=0.363N P=0.283 P=0.454N |
|COCHRAN-ARMITAGE | P=0.459 | P=0.438N |
|FISHER EXACT | P=0.002 ** P=0.513 | P=0.423 P=0.511N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/49 (29%) 7/19 (37%) 8/50 (16%) | 7/50 (14%) 2/15 (13%) 6/49 (12%) |
|ADJUSTED (b) | 30.9% 44.2% 18.3% | 18.2% 33.3% 15.0% |
|TERMINAL (d) | 7/38 (18%) 5/12 (42%) 5/40 (13%) | 3/33 (9%) 2/6 (33%) 6/40 (15%) |
|FIRST INCIDENCE (DAYS) | 483 527 562 | 625 748 (T) 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N P=0.509N P=0.122N | P=0.313N P=0.376N P=0.373N |
|INCIDENTAL TUMOR | P=0.124N P=0.370 P=0.111N | P=0.437N P=0.619N P=0.546N |
|LOGISTIC REGRESSION | P=0.089N P=0.354 P=0.069N | P=0.394N P=0.646 P=0.468N |
|COCHRAN-ARMITAGE | P=0.090N | P=0.456N |
|FISHER EXACT | P=0.351 P=0.103N | P=0.658N P=0.516N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/49 (37%) 14/19 (74%) 13/50 (26%) | 11/50 (22%) 4/15 (27%) 9/49 (18%) |
|ADJUSTED (b) | 39.8% 92.2% 29.2% | 28.5% 66.7% 21.7% |
|TERMINAL (d) | 11/38 (29%) 11/12 (92%) 9/40 (23%) | 6/33 (18%) 4/6 (67%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | 483 527 562 | 625 748 (T) 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.162N P=0.075 P=0.192N | P=0.205N P=0.577N P=0.253N |
|INCIDENTAL TUMOR | P=0.200N P=0.003 ** P=0.156N | P=0.329N P=0.440 P=0.440N |
|LOGISTIC REGRESSION | P=0.163N P=0.004 ** P=0.140N | P=0.284N P=0.397 P=0.349N |
|COCHRAN-ARMITAGE | P=0.156N | P=0.375N |
|FISHER EXACT | P=0.006 ** P=0.175N | P=0.475 P=0.421N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/49 (37%) 14/19 (74%) 13/50 (26%) | 11/50 (22%) 4/15 (27%) 9/49 (18%) |
|ADJUSTED (b) | 39.8% 92.2% 29.2% | 28.5% 66.7% 21.7% |
|TERMINAL (d) | 11/38 (29%) 11/12 (92%) 9/40 (23%) | 6/33 (18%) 4/6 (67%) 8/40 (20%) |
|FIRST INCIDENCE (DAYS) | 483 527 562 | 625 748 (T) 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.162N P=0.075 P=0.192N | P=0.205N P=0.577N P=0.253N |
|INCIDENTAL TUMOR | P=0.200N P=0.003 ** P=0.156N | P=0.329N P=0.440 P=0.440N |
|LOGISTIC REGRESSION | P=0.163N P=0.004 ** P=0.140N | P=0.284N P=0.397 P=0.349N |
|COCHRAN-ARMITAGE | P=0.156N | P=0.375N |
|FISHER EXACT | P=0.006 ** P=0.175N | P=0.475 P=0.421N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/49 (14%) 7/49 (14%) 9/50 (18%) | 4/50 (8%) 2/17 (12%) 2/49 (4%) |
|ADJUSTED (b) | 17.0% 16.7% 22.5% | 12.1% 25.0% 5.0% |
|TERMINAL (d) | 5/38 (13%) 7/42 (17%) 9/40 (23%) | 4/33 (12%) 2/8 (25%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | 665 749 (T) 749 (T) | 748 (T) 748 (T) 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.371 P=0.549N P=0.427 | P=0.195N P=0.358 P=0.251N |
|INCIDENTAL TUMOR | P=0.305 P=0.557 P=0.345 | P=0.195N P=0.358 P=0.251N |
|LOGISTIC REGRESSION | P=0.330 P=0.601N P=0.386 | P=0.195N P=0.358 P=0.251N |
|COCHRAN-ARMITAGE | P=0.355 | P=0.285N |
|FISHER EXACT | P=0.613N P=0.410 | P=0.480 P=0.349N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/49 (14%) 2/49 (4%) 2/50 (4%) | 1/50 (2%) 0/17 (0%) 1/49 (2%) |
|ADJUSTED (b) | 17.9% 4.4% 5.0% | 2.4% 0.0% 2.5% |
|TERMINAL (d) | 6/38 (16%) 1/42 (2%) 2/40 (5%) | 0/33 (0%) 0/8 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 737 527 749 (T) | 692 --- 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.037N* P=0.065N P=0.072N | P=0.617N P=0.477N P=0.723N |
|INCIDENTAL TUMOR | P=0.044N* P=0.092N P=0.091N | P=0.626 P=0.602N P=0.729 |
|LOGISTIC REGRESSION | P=0.041N* P=0.080N P=0.077N | P=0.648N P=0.718N P=0.764 |
|COCHRAN-ARMITAGE | P=0.040N* | P=0.645 |
|FISHER EXACT | P=0.080N P=0.075N | P=0.746N P=0.747 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/49 (29%) 9/49 (18%) 10/50 (20%) | 5/50 (10%) 2/17 (12%) 3/49 (6%) |
|ADJUSTED (b) | 33.8% 20.7% 25.0% | 14.3% 25.0% 7.5% |
|TERMINAL (d) | 11/38 (29%) 8/42 (19%) 10/40 (25%) | 4/33 (12%) 2/8 (25%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | 665 527 749 (T) | 692 748 (T) 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.168N P=0.125N P=0.208N | P=0.204N P=0.576 P=0.261N |
|INCIDENTAL TUMOR | P=0.223N P=0.214N P=0.288N | P=0.228N P=0.518 P=0.299N |
|LOGISTIC REGRESSION | P=0.199N P=0.160N P=0.246N | P=0.233N P=0.545 P=0.301N |
|COCHRAN-ARMITAGE | P=0.184N | P=0.306N |
|FISHER EXACT | P=0.170N P=0.224N | P=0.575 P=0.369N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.8% 2.5% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/42 (0%) 0/40 (0%) | 0/33 (0%) 1/40 (3%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 552 748 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.051N P=0.270N P=0.110N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.140N P=0.519N P=0.279N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.067N P=0.558N P=0.142N |
|COCHRAN-ARMITAGE | (e) | P=0.060N |
|FISHER EXACT | (e) (e) | P=0.309N P=0.121N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 1/7 (14%) 0/46 (0%) | 13/47 (28%) 5/46 (11%) 1/46 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 35.3% 12.7% 2.5% |
|TERMINAL (d) | 0/36 (0%) 0/0 0/38 (0%) | 10/33 (30%) 4/38 (11%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- 737 --- | 464 735 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.732 P=0.514 (e) | P<0.001N** P=0.018N* P<0.001N** |
|INCIDENTAL TUMOR | P=0.604 P=0.282 (e) | P<0.001N** P=0.043N* P<0.001N** |
|LOGISTIC REGRESSION | P=0.695N P=0.011 * (e) | P<0.001N** P=0.034N* P<0.001N** |
|COCHRAN-ARMITAGE | P=0.699 | P<0.001N** |
|FISHER EXACT | P=0.132 (e) | P=0.036N* P<0.001N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 0/7 (0%) 0/46 (0%) | 0/47 (0%) 0/46 (0%) 3/46 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 7.5% |
|TERMINAL (d) | 0/36 (0%) 0/0 0/38 (0%) | 0/33 (0%) 0/38 (0%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.048 * (e) P=0.157 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.048 * (e) P=0.157 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.048 * (e) P=0.155 |
|COCHRAN-ARMITAGE | (e) | P=0.036 * |
|FISHER EXACT | (e) (e) | (e) P=0.117 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 5.7% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/42 (0%) 0/40 (0%) | 1/33 (3%) 0/40 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 723 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.078N P=0.203N P=0.203N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.107N P=0.256N P=0.256N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.087N P=0.220N P=0.218N |
|COCHRAN-ARMITAGE | (e) | P=0.095N |
|FISHER EXACT | (e) (e) | P=0.247N P=0.247N |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 5.7% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/42 (0%) 0/40 (0%) | 1/33 (3%) 0/40 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 723 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.078N P=0.203N P=0.203N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.107N P=0.256N P=0.256N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.087N P=0.220N P=0.218N |
|COCHRAN-ARMITAGE | (e) | P=0.095N |
|FISHER EXACT | (e) (e) | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/8 (0%) 2/50 (4%) | 0/50 (0%) 0/19 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/2 (0%) 1/40 (3%) | 0/33 (0%) 0/11 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 713 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.124 (e) P=0.245 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.083 (e) P=0.155 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.134 (e) P=0.238 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.136 | (e) |
|FISHER EXACT | (e) P=0.253 | (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 2/50 (4%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.0% | 6.1% 9.5% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/42 (0%) 2/40 (5%) | 2/33 (6%) 3/40 (8%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 749 (T) | 748 (T) 700 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.098 (e) P=0.250 | P=0.169N P=0.427 P=0.197N |
|INCIDENTAL TUMOR | P=0.098 (e) P=0.250 | P=0.193N P=0.385 P=0.197N |
|LOGISTIC REGRESSION | P=0.098 (e) P=0.250 | P=0.190N P=0.383 P=0.197N |
|COCHRAN-ARMITAGE | P=0.095 | P=0.222N |
|FISHER EXACT | (e) P=0.247 | P=0.339 P=0.247N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 4/50 (8%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% | 6.1% 9.5% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/42 (0%) 1/40 (3%) | 2/33 (6%) 3/40 (8%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 749 (T) | 748 (T) 700 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.274 (e) P=0.510 | P=0.169N P=0.427 P=0.197N |
|INCIDENTAL TUMOR | P=0.274 (e) P=0.510 | P=0.193N P=0.385 P=0.197N |
|LOGISTIC REGRESSION | P=0.274 (e) P=0.510 | P=0.190N P=0.383 P=0.197N |
|COCHRAN-ARMITAGE | P=0.269 | P=0.222N |
|FISHER EXACT | (e) P=0.500 | P=0.339 P=0.247N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/48 (2%) 0/7 (0%) 1/50 (2%) | 2/49 (4%) 3/49 (6%) 2/49 (4%) |
|ADJUSTED (b) | 2.6% 0.0% 2.5% | 6.1% 7.5% 5.0% |
|TERMINAL (d) | 1/38 (3%) 0/0 1/40 (3%) | 2/33 (6%) 3/40 (8%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- 749 (T) | 748 (T) 748 (T) 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.625N (e) P=0.750N | P=0.513N P=0.588 P=0.624N |
|INCIDENTAL TUMOR | P=0.625N (e) P=0.750N | P=0.513N P=0.588 P=0.624N |
|LOGISTIC REGRESSION | P=0.625N (e) P=0.750N | P=0.513N P=0.588 P=0.624N |
|COCHRAN-ARMITAGE | P=0.634N | P=0.594 |
|FISHER EXACT | P=0.873N P=0.742N | P=0.500 P=0.691N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 3/50 (6%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | | 8.2% 2.5% 0.0% |
|TERMINAL (d) | | 2/33 (6%) 1/40 (3%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | | 625 748 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.045N* P=0.250N P=0.098N |
|INCIDENTAL TUMOR | | P=0.075N P=0.340N P=0.152N |
|LOGISTIC REGRESSION | | P=0.059N P=0.300N P=0.122N |
|COCHRAN-ARMITAGE | | P=0.060N |
|FISHER EXACT | | P=0.309N P=0.121N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 3/50 (6%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | | 8.2% 5.0% 0.0% |
|TERMINAL (d) | | 2/33 (6%) 2/40 (5%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | | 625 748 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.059N P=0.423N P=0.098N |
|INCIDENTAL TUMOR | | P=0.093N P=0.522N P=0.152N |
|LOGISTIC REGRESSION | | P=0.078N P=0.488N P=0.122N |
|COCHRAN-ARMITAGE | | P=0.082N |
|FISHER EXACT | | P=0.500N P=0.121N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 2.6% 0.0% 2.5% | 3.0% 6.9% 2.5% |
|TERMINAL (d) | 1/38 (3%) 0/42 (0%) 1/40 (3%) | 1/33 (3%) 1/40 (3%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- 749 (T) | 748 (T) 658 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.660N P=0.480N P=0.750N | P=0.548N P=0.368 P=0.718N |
|INCIDENTAL TUMOR | P=0.660N P=0.480N P=0.750N | P=0.596 P=0.275 P=0.718N |
|LOGISTIC REGRESSION | P=0.660N P=0.480N P=0.750N | P=0.598N P=0.312 P=0.718N |
|COCHRAN-ARMITAGE | P=0.669N | P=0.610 |
|FISHER EXACT | P=0.500N P=0.753N | P=0.309 P=0.753N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.9% | 5.5% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/42 (0%) 1/40 (3%) | 1/33 (3%) 0/40 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 713 | 693 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097 (e) P=0.245 | P=0.078N P=0.204N P=0.202N |
|INCIDENTAL TUMOR | P=0.060 (e) P=0.155 | P=0.107N P=0.256N P=0.256N |
|LOGISTIC REGRESSION | P=0.095 (e) P=0.237 | P=0.093N P=0.233N P=0.231N |
|COCHRAN-ARMITAGE | P=0.095 | P=0.095N |
|FISHER EXACT | (e) P=0.247 | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 3/50 (6%) | 3/50 (6%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 2.6% 0.0% 7.3% | 8.4% 6.9% 2.5% |
|TERMINAL (d) | 1/38 (3%) 0/42 (0%) 2/40 (5%) | 2/33 (6%) 1/40 (3%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- 713 | 693 658 748 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.183 P=0.480N P=0.321 | P=0.184N P=0.582N P=0.244N |
|INCIDENTAL TUMOR | P=0.136 P=0.480N P=0.248 | P=0.256N P=0.628 P=0.286N |
|LOGISTIC REGRESSION | P=0.173 P=0.480N P=0.302 | P=0.227N P=0.654N P=0.277N |
|COCHRAN-ARMITAGE | P=0.176 | P=0.238N |
|FISHER EXACT | P=0.500N P=0.309 | P=0.661N P=0.309N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 2/50 (4%) | 21/50 (42%) 12/50 (24%) 9/50 (18%) |
|ADJUSTED (b) | 10.0% 6.5% 4.5% | 54.4% 26.0% 20.6% |
|TERMINAL (d) | 3/38 (8%) 1/42 (2%) 1/40 (3%) | 16/33 (48%) 6/40 (15%) 6/40 (15%) |
|FIRST INCIDENCE (DAYS) | 693 562 381 | 451 639 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.256N P=0.468N P=0.323N | P=0.002N** P=0.018N* P=0.002N** |
|INCIDENTAL TUMOR | P=0.199N P=0.392N P=0.352N | P=0.009N** P=0.071N P=0.008N** |
|LOGISTIC REGRESSION | P=0.275N P=0.519N P=0.341N | P=0.004N** P=0.037N* P=0.005N** |
|COCHRAN-ARMITAGE | P=0.264N | P=0.005N** |
|FISHER EXACT | P=0.500N P=0.339N | P=0.044N* P=0.008N** |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 2/50 (4%) | 21/50 (42%) 12/50 (24%) 8/50 (16%) |
|ADJUSTED (b) | 7.5% 6.5% 4.5% | 54.4% 26.0% 18.3% |
|TERMINAL (d) | 2/38 (5%) 1/42 (2%) 1/40 (3%) | 16/33 (48%) 6/40 (15%) 5/40 (13%) |
|FIRST INCIDENCE (DAYS) | 693 562 381 | 451 639 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403N P=0.635N P=0.484N | P<0.001N** P=0.018N* P=0.001N** |
|INCIDENTAL TUMOR | P=0.334N P=0.575N P=0.523N | P=0.004N** P=0.071N P=0.004N** |
|LOGISTIC REGRESSION | P=0.427N P=0.640 P=0.507N | P=0.002N** P=0.037N* P=0.003N** |
|COCHRAN-ARMITAGE | P=0.412N | P=0.003N** |
|FISHER EXACT | P=0.661N P=0.500N | P=0.044N* P=0.004N** |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 18/50 (36%) 17/50 (34%) 17/50 (34%) | 23/50 (46%) 17/50 (34%) 13/50 (26%) |
|ADJUSTED (b) | 42.4% 38.6% 41.4% | 60.0% 39.3% 30.5% |
|TERMINAL (d) | 14/38 (37%) 15/42 (36%) 16/40 (40%) | 18/33 (55%) 14/40 (35%) 11/40 (28%) |
|FIRST INCIDENCE (DAYS) | 609 657 599 | 464 658 615 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403N P=0.387N P=0.445N | P=0.005N** P=0.047N* P=0.007N** |
|INCIDENTAL TUMOR | P=0.487N P=0.571N P=0.451N | P=0.018N* P=0.124N P=0.022N* |
|LOGISTIC REGRESSION | P=0.465N P=0.471N P=0.505N | P=0.014N* P=0.107N P=0.018N* |
|COCHRAN-ARMITAGE | P=0.458N | P=0.023N* |
|FISHER EXACT | P=0.500N P=0.500N | P=0.154N P=0.030N* |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.75 MG/ 1.5 MG/ | CONTROL 0.75 MG/ 1.5 MG/ |
| | M3 M3 | M3 M3 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 11/50 (22%) 15/50 (30%) | 35/50 (70%) 17/50 (34%) 16/50 (32%) |
|ADJUSTED (b) | 47.8% 23.7% 33.0% | 74.2% 36.0% 37.0% |
|TERMINAL (d) | 14/38 (37%) 7/42 (17%) 10/40 (25%) | 21/33 (64%) 10/40 (25%) 13/40 (33%) |
|FIRST INCIDENCE (DAYS) | 483 527 381 | 381 52 693 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.087N P=0.016N* P=0.114N | P<0.001N** P<0.001N** P<0.001N** |
|INCIDENTAL TUMOR | P=0.091N P=0.019N* P=0.120N | P<0.001N** P=0.001N** P<0.001N** |
|LOGISTIC REGRESSION | P=0.082N P=0.008N** P=0.106N | P<0.001N** P<0.001N** P<0.001N** |
|COCHRAN-ARMITAGE | P=0.082N | P<0.001N** |
|FISHER EXACT | P=0.016N* P=0.107N | P<0.001N** P<0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 31/50 (62%) 24/50 (48%) 30/50 (60%) | 46/50 (92%) 27/50 (54%) 27/50 (54%) |
|ADJUSTED (b) | 66.0% 51.0% 65.1% | 93.9% 56.2% 61.1% |
|TERMINAL (d) | 22/38 (58%) 19/42 (45%) 24/40 (60%) | 30/33 (91%) 19/40 (48%) 23/40 (58%) |
|FIRST INCIDENCE (DAYS) | 483 527 381 | 381 52 615 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397N P=0.081N P=0.426N | P<0.001N** P<0.001N** P<0.001N** |
|INCIDENTAL TUMOR | P=0.499N P=0.148N P=0.502N | P<0.001N** P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION | P=0.454N P=0.071N P=0.493N | P<0.001N** P<0.001N** P<0.001N** |
|COCHRAN-ARMITAGE | P=0.460N | P<0.001N** |
|FISHER EXACT | P=0.114N P=0.500N | P<0.001N** P<0.001N** |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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