TDMS Study 05096-02 Pathology Tables
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
Facility: Battelle Northwest
Chemical CAS #: 2698-41-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|
| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + + + + + A + + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + A + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + A + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Leukocytosis | |
Necrosis | 3 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 4 |
Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 3 3 2 2 2 2 2 3 2 4 2 2 2 2 3 3 3 2 2 3 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cytomegaly | 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Karyomegaly | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|
| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + + M + M M M M + M + M M M M M + M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2 1 |
Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 4 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
C-Cell, Hyperplasia | 3 |
Follicular Cell, Hyperplasia | 2 3 2 4 3 3 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X|
Cyst, Multiple | 4 |
Thrombosis | X|
Germinal Epithelium, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Dilatation | |
Hemorrhage | |
Endometrium, Hyperplasia | 4 3 3 2 3 2 3 4 4 3 3 4 1 4 4 3 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M + + + M + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 4 4 4 4 2|
Infarct | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + + + + + + + + + + + + + + + + M + +|
Cyst | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|
| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 4 |
Hemorrhage | |
Mineralization | 2 2 2 2 2 2 2 2 2|
Necrosis | 4 |
Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Leukocytosis | 3 |
Alveolus, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Alveolus, Inflammation, Suppurative | 1 |
Pleura, Fibrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Suppurative | 1 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + I + + + I + A + + + I + + + A I I + A + +|
Cornea, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|
| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy, Chronic | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4| |
| 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + A + + A A + + A + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + A + + + A + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + A + + + A M + M + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + A + + + A A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + A + + A A + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + A + + A A + + A + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + A + + A A + + + + + + + + +| 44 |
Amyloid Deposition | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + A + + A A + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 | 1 2.0|
Eosinophilic Focus | 4 | 1 4.0|
Hepatodiaphragmatic Nodule | | 1 |
Leukocytosis | 4 X | 2 4.0|
Necrosis | 4 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fibrosis | | 1 4.0|
Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Duct, Dilatation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + M + + + +| 48 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 1.0|
Epithelium, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 2.0|
Hemorrhage | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2| 49 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4| |
| 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Cytomegaly | 2 | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Karyomegaly | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M M M M M M + + M + M M M M M M + M M + + M| 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + I + + + + + + + +| 47 |
Angiectasis | 2 2 | 6 2.2|
Cyst | | 1 |
Pars Distalis, Hyperplasia | 3 2 2 3 3 3 2 | 16 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Inflammation, Suppurative | 2 | 2 2.0|
C-Cell, Hyperplasia | | 1 3.0|
Follicular Cell, Hyperplasia | 3 3 3 2 2 2 2 2 2 | 17 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X | 15 |
Cyst, Multiple | | 1 4.0|
Thrombosis | | 1 |
Germinal Epithelium, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Dilatation | 4 4 | 2 4.0|
Hemorrhage | 4 | 1 4.0|
Endometrium, Hyperplasia | 2 2 2 2 2 2 4 2 2 2 1 2 | 30 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 3| 36 1.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + M + M + + + M + +| 44 |
Hematopoietic Cell Proliferation | 4 | 5 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4| |
| 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 4 | 9 3.6|
Infarct | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + M + + + + + + + + + M + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + M + + + + + + + +| 45 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 2 | 5 3.0|
Hemorrhage | 2 3 | 2 2.5|
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 | 20 2.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Leukocytosis | 4 4 2 | 4 3.3|
Alveolus, Hyperplasia | 2 2 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 4 4 | 5 3.2|
Alveolus, Inflammation, Suppurative | 2 | 2 1.5|
Pleura, Fibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 1 2.0|
Hemorrhage | 4 3| 2 3.5|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Suppurative | 2 2 1 1 1 | 8 1.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 4 4 2 | 7 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4| |
| 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + I I + A + + + + + A + + + A + + A I + + I I +| 33 |
Cornea, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Mineralization | 2 | 1 2.0|
Nephropathy, Chronic | 2 1 2 2 2 1 1 3 2 2 2 2 3 2 3 2 2 3 2 | 41 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + A + + + A + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 5| 0| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 5| 1| 0| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Gallbladder | M A + A + + |
__________________________________________________________________________|
Intestine Large | + + + + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + |
__________________________________________________________________________|
Liver | + + + + + + + |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + |
Developmental Malformation | X |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + I +|
Acanthosis | 4 4 2 |
Cyst | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
Capsule, Hyperplasia | 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M + + M |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 5| 0| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 5| 1| 0| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia, | |
Multiple | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + +|
Cyst | X X X X X|
Cyst, Multiple | X |
__________________________________________________________________________|
Uterus | + + + + + + |
Dilatation | 3 4 |
Hemorrhage | |
Thrombosis | X |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Myelofibrosis | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Hyperplasia, Lymphoid | |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M |
__________________________________________________________________________|
Spleen | + + + + + + + + + M |
Hematopoietic Cell Proliferation | 4 4 4 |
__________________________________________________________________________|
Thymus | M + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Mineralization | 2 2 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 3| 5| 0| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 5| 1| 0| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 8| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + |
Alveolus, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Serous | 2 |
Hemorrhage | |
Inflammation, Suppurative | 1 1 1 3 2 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Nephropathy, Chronic | 2 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + M + + + |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 5| 6| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 2| |
| 1| 7| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 2| 1| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + A + +| 10 |
__________________________________________________________________________|____________|
Gallbladder | + + A M A| 5 |
__________________________________________________________________________|____________|
Intestine Large | + + A + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + A M +| 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small | + + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A| 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + +| 9 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + +| 15 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + +| 11 |
Developmental Malformation | | 1 |
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + A + +| 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Acanthosis | | 3 3.3|
Cyst | X | 1 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Erosion | 3 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + A + +| 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + A + +| 10 |
Capsule, Hyperplasia | 2 1 2| 9 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + A + +| 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + +| 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + +| 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M A + M| 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 5| 6| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 2| |
| 1| 7| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 2| 1| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + A M + + + +| 46 |
Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 3 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 2 2 3 | 6 2.2|
Follicular Cell, Hyperplasia, | | |
Multiple | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + A + + +| 20 |
Cyst | X X X X X | 10 |
Cyst, Multiple | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + A + +| 15 |
Dilatation | | 2 3.5|
Hemorrhage | 4 | 1 4.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia | 2 3 3 4 2| 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + +| 10 |
Myelofibrosis | 2 2| 5 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + A + + +| 15 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + A + +| 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + +| 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + +| 19 |
Hematopoietic Cell Proliferation | 3 3 4 4 | 7 3.7|
__________________________________________________________________________|____________|
Thymus | + + A + + +| 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + A M +| 10 |
__________________________________________________________________________|____________|
Skin | + + + + + A + +| 17 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 5| 6| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 2| |
| 1| 7| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 2| 1| 1| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + +| 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + +| 11 |
Mineralization | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + A + +| 10 |
__________________________________________________________________________|____________|
Lung | + + + + + + + A + + + +| 17 |
Alveolus, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Exudate, Serous | | 1 2.0|
Hemorrhage | 1 | 1 1.0|
Inflammation, Suppurative | 1 1 1| 9 1.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 1.5|
Respiratory Epithelium, Hyperplasia | 1 1 2| 4 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 2| 6 1.7|
__________________________________________________________________________|____________|
Trachea | + + A + +| 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + +| 13 |
Nephropathy, Chronic | 1 2 1| 7 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + +| 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|
| 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + A A + + + + + + + + A + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + A + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Leukocytosis | |
Necrosis | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Erosion | |
Inflammation, Suppurative | 2 |
Epithelium, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Artery, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 2 2 4 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | |
Cytomegaly | 2 1 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|
| 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M M + + + + + + + + + + + + M M M + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + I + + + + + + + + + + + + + + + + A + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X X X X X X |
Hemorrhage | 4 |
Mineralization | |
Germinal Epithelium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 4 2 |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 2 |
Endometrium, Hyperplasia | 2 3 2 2 2 2 2 2 2 1 2 2|
Endometrium, Metaplasia, Squamous | 2|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Angiectasis | 3 |
Pancreatic, Inflammation, Suppurative| 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hematopoietic Cell Proliferation | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + M + + + + + + + M + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | 4 3 |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|
| 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 4 3 3 2 3 3|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hemorrhage | |
Inflammation, Suppurative | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | 3 2 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + M + + + +|
Artery, Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 3 3 |
Leukocytosis | 2 2 |
Alveolus, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 4 |
Alveolus, Inflammation, Suppurative | 2 2 |
Artery, Mineralization | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Suppurative | 2 1 2 2 2 2 2|
Olfactory Epithelium, Atrophy | |
Respiratory Epithelium, Hyperplasia | 2 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 1 1 2 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|
| 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + I + + + + I + I I A + + A + + + + A I + + + +|
Atrophy | |
Hemorrhage | |
Lens, Cataract | |
Retina, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Mineralization | |
Nephropathy, Chronic | 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 1 3 4 3 1 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + M + + + + + A + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + A + + A + A + + + + A + + + + +| 40 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + A + + A + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + A + + + + + + A + + A + A + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + M + + A + + A + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + A + + A + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + A + + A + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + A + + A + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + A + + A + A + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + A + + A + A + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Angiectasis | 4 | 1 4.0|
Clear Cell Focus | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Leukocytosis | X | 1 |
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + A + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + A + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + A + A + + + + + + + + + +| 47 |
Erosion | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Epithelium, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 | 1 2.0|
Artery, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 3 3 2| 48 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Cyst | X | 1 |
Cytomegaly | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hemorrhage | | 1 2.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + M + + + M + + + + + + + M + M + +| 36 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + A + + + + + + + + + + + +| 46 |
Pars Distalis, Hyperplasia | 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 2 2.0|
Follicular Cell, Hyperplasia | 3 3 2 | 5 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Cyst | X X X X | 10 |
Hemorrhage | 2 4 3 | 4 3.3|
Mineralization | 3 | 1 3.0|
Germinal Epithelium, Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Dilatation | 4 4 4 4 4 | 8 3.8|
Hemorrhage | 3 4 | 3 3.3|
Inflammation, Suppurative | 3 | 3 2.3|
Endometrium, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 1 | 23 2.0|
Endometrium, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Myelofibrosis | 2 2 2 3 2 2 2 2 2 2 4 2 2 2 2 2 2 2 2 2 | 42 2.0|
Myeloid Cell, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + A M + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Angiectasis | | 1 3.0|
Pancreatic, Inflammation, Suppurative| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + A M + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + M M M + + + M M + M + + M| 38 |
Cyst | X | 1 |
Hematopoietic Cell Proliferation | 4 4 | 4 3.8|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 4 4 | 10 3.3|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + M + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + M + + M + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Acanthosis | 3 | 2 2.5|
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Compression | 3 | 1 3.0|
Hemorrhage | | 2 2.5|
Mineralization | 2 2 2 2 2 | 17 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + A + A + + + + + + + + + +| 47 |
Artery, Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Congestion | 4 3 | 2 3.5|
Hemorrhage | | 2 3.0|
Leukocytosis | X 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Hyperplasia | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 5 2.6|
Alveolus, Inflammation, Suppurative | | 2 2.0|
Artery, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Suppurative | 1 1 2 2 1 3 3 1 1 3 2| 18 1.8|
Olfactory Epithelium, Atrophy | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 2| 7 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 2 3 1 2 2 3 2 | 17 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + A + A + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + A + + + + + + + + + I + A + + + + + + + + + +| 38 |
Atrophy | 4 | 1 4.0|
Hemorrhage | 4 | 1 4.0|
Lens, Cataract | 2 | 1 2.0|
Retina, Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Developmental Malformation | | 1 |
Mineralization | 2 | 1 2.0|
Nephropathy, Chronic | 2 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 3 1 1| 47 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + A + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|
| 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M A M + + + + A + + + + + + + + + + + + A + +|
Infarct | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 2 4 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | |
Infarct | 4 2 |
Inflammation, Granulomatous | 4 |
Leukocytosis | 3 |
Necrosis | 4 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinar Cell, Hypertrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 2 2 2 2 1 2 1 2 1 3 2 3 1 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytomegaly | 2 2 2 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|
| 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M M M + + M M M + M + + M + + M + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + A + + + + + + + + M + + + + I + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Penis | + + + |
Concretion | 4 4 |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Preputial Gland | + |
Cyst | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + M + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Mineralization | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inguinal, Hematopoietic Cell | |
Proliferation | 4 |
Mesenteric, Angiectasis | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + M + + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + M + + M M + + + + M + + M + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|
| 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Inflammation, Suppurative | 4 4 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 4 |
Leukocytosis | 3 |
Alveolus, Hyperplasia | 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 4 |
Alveolus, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Suppurative | 3 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | I + A I + + + + I + + I + + + + + + + + + + + + +|
Cornea, Inflammation, Suppurative | |
Retina, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|
| 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Nephropathy, Chronic | 1 2 1 3 1 2 1 2 1 2 2 2 2 1 1 2 2 2 2 3|
Pelvis, Inflammation, Suppurative | 4 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
Inflammation, Suppurative | 3 4 4 |
Metaplasia, Squamous | 3 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| |
| 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + A M + + + + + A + + A A + + + + + + + + + + + +| 39 |
Infarct | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + M + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A A + + + + + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + A + + A + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A M + + + + + A + + A + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + A + + A + + + A + + + + + + + + +| 43 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A A + + + + + A + + A + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Clear Cell Focus | | 2 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hyperplasia | 3 3 | 2 3.0|
Infarct | | 2 3.0|
Inflammation, Granulomatous | | 1 4.0|
Leukocytosis | | 1 3.0|
Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinar Cell, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A I + + + + + + + + + + + + + + + + + + + + + +| 47 |
Acanthosis | 1 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 3 | 2 2.5|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| |
| 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 2 2 2 2 2 1 2 1 2 2 2 2 2 2 1 1 2 1 1 2 2| 41 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Cytomegaly | 3 2 2 2 1 2 | 10 2.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + M + M + + M M + + + M + M M M M M M M| 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 2 2 2| 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + A + + + + + M + + + + M M + + + + + + + + + + +| 46 |
Inflammation, Suppurative | 3| 1 3.0|
__________________________________________________________________________|____________|
Penis | + + | 5 |
Concretion | | 2 4.0|
Inflammation, Suppurative | 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + +| 4 |
Cyst | X X| 2 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 3| 4 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + A + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Dilatation | | 1 4.0|
Inflammation, Suppurative | 3 | 3 2.7|
__________________________________________________________________________|____________|
Testes | + A + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Atrophy | 4 3 4 2 1 1 2 | 9 2.3|
Mineralization | | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inguinal, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| |
| 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation | | 1 4.0|
Mesenteric, Angiectasis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A + + + + + + + + + M + + + + + + + + + + M + +| 42 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 3 | 2 2.5|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + + M + + + + + + M M + M + + +| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M A M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 4.0|
Inflammation, Suppurative | 4 4| 4 4.0|
Ulcer | 2 3| 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 1 1 2 2 2 2 1 2 2 | 17 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Granulomatous | | 1 4.0|
Leukocytosis | 3 | 2 3.0|
Alveolus, Hyperplasia | 2 3 2 2 | 6 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 3.0|
Alveolus, Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| |
| 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 2 2.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + M A + + + + + A + + A + + + + + + + + + + + + +| 41 |
Cornea, Inflammation, Suppurative | 2 | 1 2.0|
Retina, Vacuolization Cytoplasmic | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 4 | 1 4.0|
Nephropathy, Chronic | 2 2 2 2 2 2 2 3 2 2 2 2 1 2 3 1 3 2 2 2 2 2 2| 43 1.9|
Pelvis, Inflammation, Suppurative | 3| 4 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 3 2.3|
Inflammation, Suppurative | 3 4| 5 3.6|
Metaplasia, Squamous | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 5| 5| 0| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Gallbladder | A + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + |
__________________________________________________________________________|
Intestine Small | A + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A A M + |
__________________________________________________________________________|
Liver | + + + + + + + + |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Artery, Thrombosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + I + + + + + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
Capsule, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M M |
__________________________________________________________________________|
Pituitary Gland | + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + |
__________________________________________________________________________|
Penis | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 5| 5| 0| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + |
Cyst | X X |
Hyperplasia | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Prostate | + + + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Dilatation | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + |
Atrophy | 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Mesenteric, Hematopoietic Cell | |
Proliferation | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + |
__________________________________________________________________________|
Spleen | + + + + |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M |
__________________________________________________________________________|
Skin | + + + + + + + |
Inflammation, Suppurative | 4 4 2 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 5| 5| 0| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukocytosis | 2 |
Alveolus, Hyperplasia | 2 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + I + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Suppurative | 2 2 2 4 1 2 2 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 2 3 2 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 3 2 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Nephropathy, Chronic | 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + |
Dilatation | 3 |
Hyperplasia | 1 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 8| 5| 5| 1| 5| 5| |
| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 5| 2| 2| 3| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + | 7 |
__________________________________________________________________________|____________|
Gallbladder | + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Large | + A A + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A A + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Small | A + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A A + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A A + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + A + + + + +| 19 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | 3 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Artery, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + M + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + A + + | 7 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + M + + + +| 45 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Erosion | | 1 3.0|
Inflammation, Suppurative | 1 | 1 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + | 7 |
Capsule, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + A + + | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + | 7 |
Follicular Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 8| 5| 5| 1| 5| 5| |
| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 5| 2| 2| 3| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + A + + | 7 |
__________________________________________________________________________|____________|
Penis | +| 1 |
Inflammation, Suppurative | 4| 1 4.0|
Necrosis | 4| 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 5 |
Cyst | 1 | 3 1.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 4 | 3 3.7|
__________________________________________________________________________|____________|
Prostate | + A + + | 7 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 9 |
Dilatation | 3 | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + A + + | 7 |
Atrophy | 1 | 2 2.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + | 7 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + A + + + | 9 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | A + M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A + + | 4 |
__________________________________________________________________________|____________|
Spleen | + + M + + M | 8 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | M M + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M | |
__________________________________________________________________________|____________|
Skin | + + + A + + + | 13 |
Inflammation, Suppurative | | 3 3.3|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 7| 7| 5| 7| 7| |
DAY ON TEST | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 8| 5| 5| 1| 5| 5| |
| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 5| 2| 2| 3| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + A + + | 7 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + | 7 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Leukocytosis | | 1 2.0|
Alveolus, Hyperplasia | 2 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | 2 1 1 1 2 2| 16 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 8 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 2| 12 1.8|
__________________________________________________________________________|____________|
Trachea | + A + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 4.0|
Nephropathy, Chronic | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 2| 40 1.2|
Pelvis, Inflammation, Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A A + +| 7 |
Dilatation | | 1 3.0|
Hyperplasia | | 2 2.0|
Inflammation, Suppurative | 4| 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + M + + M + M + + + + + + + + + + A A M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + A + +|
Developmental Malformation | |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + A + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 3 4 |
Infarct | |
Inflammation, Suppurative | 1 |
Leukocytosis | |
Necrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + I + + +|
Inflammation, Suppurative | 1 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + I + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 1 2 1 2 1 2 2 1 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + I + + + + + + +|
Cytomegaly | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + I + + + + + + +|
Karyomegaly | |
Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + M + M M M M + M + + M M M M M + M|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 2 |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Penis | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + + + |
Cyst | X |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Suppurative | 4 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + M + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + M + + + + + + + + + + + + M M + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + + M + M + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Hemorrhage | |
Inflammation, Suppurative | 4 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Leukocytosis | |
Alveolus, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 2 2 2 3 1 2 2 2 1 |
Olfactory Epithelium, Atrophy | 1 |
Respiratory Epithelium, Hyperplasia | 1 2 1 1 2 2 1 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + A + + + + + + + I + + A + +|
Retina, Vacuolization Cytoplasmic | 2 1 1 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Infiltration Cellular, Diffuse, | |
Polymorphonuclear | |
Inflammation, Suppurative | 4 |
Mineralization | 3 2 |
Nephropathy, Chronic | 2 2 2 2 2 2 2 3 2 2 2 1 1 2 2 2 3 1 2 2 1 2 2 2 2|
Artery, Inflammation | 2 |
Pelvis, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|
DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 4 4 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5| |
| 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + A + + + A + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A M + + + + + + + + + M + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + A + + M A + + + + + + + + +| 44 |
Developmental Malformation | X | 1 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + A + + + A + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Eosinophilic Focus | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia | | 2 3.5|
Infarct | 2 | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Leukocytosis | 4 | 1 4.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 2 1 2 2 2 2 1 2 2 1 2 2 3 1 2 2 2| 34 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5| |
| 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cytomegaly | 2 2 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Karyomegaly | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + M + M M M + + M + M M M M M + + + +| 24 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + I + M + + + + I + +| 46 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Inflammation, Suppurative | | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 1 3 | 6 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 4 |
Cyst | | 1 |
Inflammation, Suppurative | 4 | 3 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 4 | 2 4.0|
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 5 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + M + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + M + M + + + + + M M + + + + + + + + M M + M| 35 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5| |
| 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 3 3 3 3| 6 3.0|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + M M + + + M + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 4.0|
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 4 4 | 6 4.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 2 2| 16 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Leukocytosis | 2 4 | 2 3.0|
Alveolus, Hyperplasia | 4 | 2 3.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 4 4 | 4 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 2 2 3 2 1 2 2 2 1 3 3 | 23 2.1|
Olfactory Epithelium, Atrophy | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 2 2 | 12 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 2 3 1 3 1 2 2 2 2 2 2 2 2| 24 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + A + + + + A + + + A + I + + + + + + +| 43 |
Retina, Vacuolization Cytoplasmic | 1 1 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05096-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:52:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5| |
| 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 4 |
Infiltration Cellular, Diffuse, | | |
Polymorphonuclear | 4 | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
Mineralization | | 2 2.5|
Nephropathy, Chronic | 2 2 2 2 2 2 2 1 2 2 2 2 2 3 2 2 2 2 2 2 2 2| 47 2.0|
Artery, Inflammation | | 1 2.0|
Pelvis, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Hyperplasia | 2 | 3 1.3|
Inflammation, Suppurative | | 3 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 425145-425145/425145
--multipart-boundary--