Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1176

TDMS Study 05096-02 Pathology Tables

NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14




       Facility:  Battelle Northwest

       Chemical CAS #:  2698-41-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|             
                                           | 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                  X                                       |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |             3                                1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                 +        +                    +                     |             
      Fibrosis                             |    4                                                                     |             
      Necrosis                             |                      4                             4                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2                                                      |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1                                                                  |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                     2                                    |             
      Hemorrhage                           |                                     2  2                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  3  3  2  2  2  2  2  3  2  4  2  2  2  2  3  3  3  2  2  3  2  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       4                  |             
      Cytomegaly                           |                3                             2  2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Karyomegaly                          |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|             
                                           | 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  +  M  +  M  M  M  M  +  M  +  M  M  M  M  M  +  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3           3                 2        1                  |             
      Cyst                                 |                                                                      X   |             
      Pars Distalis, Hyperplasia           |                      2  2  2        3  2        2     4        2     3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                 2                        |             
      C-Cell, Hyperplasia                  |                                              3                           |             
      Follicular Cell, Hyperplasia         |                      2  3        2  4     3  3              3        3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X        X           X           X        X  X     X     X        X|             
      Cyst, Multiple                       |                                              4                           |             
      Thrombosis                           |                                                                         X|             
      Germinal Epithelium, Hyperplasia     |                2        3              2                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia             |    4     3     3     2  3  2  3  4  4  3  3  4     1     4  4  3     3  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 2  2  1  2     2  2  2  2  2  2  2  2        2  2  2     1  2        2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  4        4                             2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  3  3           3                 3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2                          4  4  4  4                    4        2|             
      Infarct                              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|             
                                           | 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               3                                   4      |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       | 2     2     2        2        2  2     2                          2     2|             
      Necrosis                             |                                                                   4      |             
      Vacuolization Cytoplasmic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Leukocytosis                         |                                        3                                 |             
      Alveolus, Hyperplasia                | 3                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                3         |             
      Alveolus, Inflammation, Suppurative  |                         1                                                |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Suppurative            |             1     1                                            2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                 2     3           2      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  I  +  +  +  I  +  A  +  +  +  I  +  +  +  A  I  I  +  A  +  +|             
      Cornea, Inflammation, Suppurative    |                                                 4                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                 +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                        2                                 |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 1| 0| 4| 4| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 0| 4| 4| 9| 7| 4| 4|             
                                           | 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 7| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy, Chronic                 | 2  2  2  2     2     2  3  2     2  2  2  2  2  2  2  2  2  2  3  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4|            |
                                           | 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  A  +  +  A  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  M  +  M  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  A  +  +  A  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +|  44        |
      Amyloid Deposition                   |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                            2                                             |      1  2.0|
      Eosinophilic Focus                   |                               4                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Leukocytosis                         |                                  4                             X         |      2  4.0|
      Necrosis                             |                                  4                                       |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fibrosis                             |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Duct, Dilatation                     |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Inflammation, Suppurative            |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |       1                                1                                 |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Hyperplasia                 | 2  2  2  3  2  2  2  2  2  2  2  3  2  2  3  2     2  2  2  2  2  2  2  2|     49  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4|            |
                                           | 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Cytomegaly                           |                               2                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Karyomegaly                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  M  M  M  M  M  +  +  M  +  M  M  M  M  M  M  +  M  M  +  +  M|  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  47        |
      Angiectasis                          |    2           2                                                         |      6  2.2|
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                3     2  2  3        3     3                    2         |     16  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                     2                                    |      2  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         | 3        3     3        2  2  2     2              2           2         |     17  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X                          X        X        X           X        X      |     15     |
      Cyst, Multiple                       |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
      Germinal Epithelium, Hyperplasia     |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Dilatation                           |                                     4                          4         |      2  4.0|
      Hemorrhage                           |                4                                                         |      1  4.0|
      Endometrium, Hyperplasia             |       2  2  2     2  2  2  4        2              2  2  1     2         |     30  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        | 2  1  2  2  1  2     2  2  2  2     2  2  2  2     2     2              3|     36  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  +|  44        |
      Hematopoietic Cell Proliferation     |                                                                4         |      5  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4|            |
                                           | 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                              4                 4         |      9  3.6|
      Infarct                              |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | 3                                                        3  2            |      5  3.0|
      Hemorrhage                           |                                  2                    3                  |      2  2.5|
      Mineralization                       |    2     2  2  2     2           2     2  2  2     2              2      |     20  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           4                              |      1  4.0|
      Leukocytosis                         |                                  4           4                    2      |      4  3.3|
      Alveolus, Hyperplasia                |                   2                       2                              |      3  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 2        3              4                 4                              |      5  3.2|
      Alveolus, Inflammation, Suppurative  |          2                                                               |      2  1.5|
      Pleura, Fibrosis                     |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                           2                              |      1  2.0|
      Hemorrhage                           |                                           4                             3|      2  3.5|
      Inflammation, Acute                  |                         2                                                |      1  2.0|
      Inflammation, Suppurative            |          2                 2              1  1                 1         |      8  1.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   2                       4                    4  2      |      7  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 6| 3| 7| 2| 7| 4| 7| 6| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 5| 4| 4| 9| 1| 8| 4| 6| 4| 6| 2| 2| 4| 4|            |
                                           | 9| 9| 9| 9| 9| 0| 1| 9| 9| 9| 9| 2| 9| 9| 3| 5| 1| 9| 3| 9| 4| 3| 5| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           4                              |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  I  I  +  A  +  +  +  +  +  A  +  +  +  A  +  +  A  I  +  +  I  I  +|  33        |
      Cornea, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +              +                                 |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Mineralization                       |                         2                                                |      1  2.0|
      Nephropathy, Chronic                 | 2  1  2  2     2  1  1  3  2  2     2  2  3        2     3  2  2  3  2   |     41  2.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 0| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 5| 1| 0| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +           +     +                    +                 +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    M     A           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     A           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +           A     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +           +     A                    +                 +      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +           +     +                 +  +                 +      |             
      Necrosis                             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +           +                          +     +           +      |             
      Developmental Malformation           |                                                       X                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +           +     +                    +                 +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Acanthosis                           |       4                                               4     2            |             
      Cyst                                 |                                                                          |             
      Ulcer                                |                                                       4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    2                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Developmental Malformation           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +           +     +                    +                 +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +           +     +                    +                 +      |             
      Capsule, Hyperplasia                 |    2     2           2     2                    2                 2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +           +     +                    +                 +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +           +     +                    +                 +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +           +                          +                 +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     M           M     +                    +                 M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                           2  1     2                 2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 0| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 5| 1| 0| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                          2               |             
      Follicular Cell, Hyperplasia,        |                                                                          |             
          Multiple                         |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +  +        +        +  +     +        +           +     +     +|             
      Cyst                                 |                               X  X     X                    X           X|             
      Cyst, Multiple                       |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +           +     +                    +                 +      |             
      Dilatation                           |                                                 3                 4      |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                   X      |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +           +     +                    +                 +      |             
      Myelofibrosis                        |          2                 2                                      2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +           +     +                    +     +           +      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +     +           +     +                    +                 +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +     +           +     +                    +                 M      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +        +  +     +  +                 +           +  +  M      |             
      Hematopoietic Cell Proliferation     |                   4                                         4  4         |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M     +           +     +                    +                 +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +           +     +                    +                 +      |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +        +     +     +  +           +  +              +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +           +  +  +                    +                 +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +           +     +                    +                 +      |             
      Mineralization                       |                      2     2                    2                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +     +           +     +                    +                 +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 0| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 1| 5| 1| 0| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 8| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +           +     +                    +                 +      |             
      Alveolus, Hyperplasia                |                                                 2                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Serous                      |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |       1           1     1  3                       2                    1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           1                              |             
      Respiratory Epithelium, Hyperplasia  |                                                    1                     |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2              1        2                       2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +           +     +                    +                 +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +           +     +                    +                 +      |             
      Nephropathy, Chronic                 |    2                       2                    2                 1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     M           +                          +                 +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 6| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 2|            |
                                           | 1| 7| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 2| 1| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +                                               A  +           +|  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +     +                                               A  M           A|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +                                               A  +           +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    M     +                                               A  M           +|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +                                               A  +           +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +                                               A  +           +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +                                               A  +           +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +                                               A  +           A|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +                                               A  +           +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +                                               A  +           +|   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +        +           +                    +     A  +  +        +|  15        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
      Inflammation, Chronic                | 4                                                                        |      1  4.0|
      Necrosis                             | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +                                               A  +           +|  11        |
      Developmental Malformation           |                                                                          |      1     |
      Inflammation, Chronic                | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +                                               A  +           +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Acanthosis                           |                                                                          |      3  3.3|
      Cyst                                 |          X                                                               |      1     |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Erosion                              |          3                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +                                               A  +           +|  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +                                               A  +           +|  10        |
      Capsule, Hyperplasia                 |    2     1                                                              2|      9  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +                                               A  +           +|  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +                                               A  +           +|  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +                                               A  +           +|   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     M                                               A  +           M|   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 6| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 2|            |
                                           | 1| 7| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 2| 1| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  M  +  +  +  +|  46        |
      Cyst                                 |                                                    X                     |      1     |
      Pars Distalis, Hyperplasia           |                      2        3  2     2                                 |      8  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                   2  2                          2                 2  3   |      6  2.2|
      Follicular Cell, Hyperplasia,        |                                                                          |            |
          Multiple                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +  +        +                    +              A  +        +  +|  20        |
      Cyst                                 | X           X        X                    X                          X   |     10     |
      Cyst, Multiple                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +     +           +     +              +     A  +           +|  15        |
      Dilatation                           |                                                                          |      2  3.5|
      Hemorrhage                           |                                                    4                     |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
      Endometrium, Hyperplasia             |          2                    3     3              4                    2|      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +                                               A  +           +|  10        |
      Myelofibrosis                        |          2                                                              2|      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +        +           +                    +     A  +  +        +|  15        |
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     +        +                                      A  +           +|  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     +        +                                +     M  +           +|  11        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +     +                    +        +  +     A  +  +        +|  19        |
      Hematopoietic Cell Proliferation     |             3                          3        4           4            |      7  3.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +                                               A  +  +        +|  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +              +                                A  M           +|  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +                          +              +  A  +           +|  17        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 6| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 2|            |
                                           | 1| 7| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 2| 1| 1| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +                                               +  +           +|  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +                                               +  +           +|  11        |
      Mineralization                       |          2                                               2               |      5  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +     +                                               A  +           +|  10        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +              +  +        +              +  +  A  +  +     +  +|  17        |
      Alveolus, Hyperplasia                |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                            3        2                                    |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Exudate, Serous                      |                                                                          |      1  2.0|
      Hemorrhage                           |                                        1                                 |      1  1.0|
      Inflammation, Suppurative            |                                                 1  1                    1|      9  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   2                                                      |      2  1.5|
      Respiratory Epithelium, Hyperplasia  | 1                                               1                       2|      4  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                 1                       2|      6  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +                                               A  +           +|  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +        +                                 |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +        +                       +              A  +  +        +|  13        |
      Nephropathy, Chronic                 |          1                                                  2           1|      7  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +                                               A  +           +|   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|             
                                           | 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +     +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |             1                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            |                                           2                              |             
      Epithelium, Hyperplasia              |             1                                      1           1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  3  2  2  2  2  2  2  2  2  2  2  3  2  2  1  2  2  2     2  4  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        3                                 |             
      Cyst                                 |                                                                          |             
      Cytomegaly                           |                      2                                      1     1      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                    2                     |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|             
                                           | 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          2                       2                    2              2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2              2                                             |             
      Follicular Cell, Hyperplasia         |                                                 2  2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +                                                                  |             
      Inflammation, Suppurative            |       3                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                                                   |             
      Cyst                                 |          X                                   X  X              X  X  X   |             
      Hemorrhage                           |                                                          4               |             
      Mineralization                       |                                                                          |             
      Germinal Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                               4     4        2                           |             
      Hemorrhage                           |                                                       3                  |             
      Inflammation, Suppurative            |       2        2                                                         |             
      Endometrium, Hyperplasia             | 2           3        2  2        2     2           2  2     2  1     2  2|             
      Endometrium, Metaplasia, Squamous    |                                                                         2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 2  2  2  2  2  2  2  2  2        2  2  2     1  2  2  2  2  2  2  2  2  2|             
      Myeloid Cell, Hyperplasia            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Angiectasis              | 3                                                                        |             
      Pancreatic, Inflammation, Suppurative| 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     | 4                    3                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|             
                                           | 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                4        3                       4  3        3     2  3  3|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          2                                                               |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                               3                          2               |             
      Mineralization                       | 2                 2     2  2  2  2  2        2  2           2        2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |       3                       3                                          |             
      Leukocytosis                         |                                                 2        2               |             
      Alveolus, Hyperplasia                |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                            2              3                 4            |             
      Alveolus, Inflammation, Suppurative  |                                     2                       2            |             
      Artery, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                      2   |             
      Inflammation, Suppurative            |    2           1           2        2                       2     2     2|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                               2                          2     2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2           2     1     1     2  2                       2  1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 0| 0| 4| 4| 4| 4| 4| 4| 0| 9| 4| 4| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4|             
                                           | 8| 9| 9| 8| 8| 8| 8| 8| 8| 9| 3| 8| 8| 8| 5| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  I  +  +  +  +  I  +  I  I  A     +  +  A  +  +  +  +  A  I  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Vacuolization Cytoplasmic    |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           | X                                                                        |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 2  2  1  2  2  2  2  2  2  2     2  2  1  2  2  1  3     4  3  1  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  A  +  +  +  +  +|  40        |
      Inflammation, Suppurative            |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  M  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                               4                                          |      1  4.0|
      Clear Cell Focus                     |                               4                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                              3                           |      1  3.0|
      Leukocytosis                         |                            X                                             |      1     |
      Necrosis                             |                            4                                             |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Erosion                              |       2                                                                  |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                        2                                 |      1  2.0|
      Artery, Inflammation                 |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 2  2  1  2  2  2  2  2  2  2  3  2     2  2  2  2  2  2  2  2  3  3  3  2|     48  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                         X                                                |      1     |
      Cytomegaly                           |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                              4                           |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +|  36        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Hyperplasia           |                      2           2           2                           |      7  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Follicular Cell, Hyperplasia         | 3        3                             2                                 |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                  X           X  X              X         |     10     |
      Hemorrhage                           |                   2           4           3                              |      4  3.3|
      Mineralization                       |                               3                                          |      1  3.0|
      Germinal Epithelium, Hyperplasia     |                                  3              3                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           |                4                                4           4  4     4   |      8  3.8|
      Hemorrhage                           |                   3        4                                             |      3  3.3|
      Inflammation, Suppurative            |                            3                                             |      3  2.3|
      Endometrium, Hyperplasia             |          2        3     2     2  2     2        2  2  2  2     1         |     23  2.0|
      Endometrium, Metaplasia, Squamous    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        | 2  2  2  3  2  2  2  2  2  2  4  2     2           2  2  2  2  2  2  2   |     42  2.0|
      Myeloid Cell, Hyperplasia            |                                              3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Angiectasis              |                                                                          |      1  3.0|
      Pancreatic, Inflammation, Suppurative|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     |                                              4                           |      1  4.0|
      Pigmentation                         |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  M  M  M  +  +  +  M  M  +  M  +  +  M|  38        |
      Cyst                                 |                                                                   X      |      1     |
      Hematopoietic Cell Proliferation     |                                              4                       4   |      4  3.8|
      Hyperplasia, Lymphoid                |                                              3                           |      1  3.0|
      Inflammation, Suppurative            | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                              4                    4      |     10  3.3|
      Necrosis                             |                                           4                              |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                   3      |      2  2.5|
      Hemorrhage                           |                                           4                              |      1  4.0|
      Inflammation, Suppurative            |                                                                   3      |      1  3.0|
      Ulcer                                |                                              4                    4      |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |                                                             3            |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Mineralization                       | 2  2                       2           2                       2         |     17  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Artery, Inflammation                 |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                         4     3                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      2  3.0|
      Leukocytosis                         |                            X                 2                           |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 8| 8| 6| 8| 8| 8| 8| 8| 8| 5| 8| 8| 7| 8| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Hyperplasia                |                                                 3                        |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                 2                    2   |      5  2.6|
      Alveolus, Inflammation, Suppurative  |                                                                          |      2  2.0|
      Artery, Mineralization               |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                       2                  |      2  2.0|
      Inflammation, Suppurative            | 1  1  2        2              1           3  3           1  1  3        2|     18  1.8|
      Olfactory Epithelium, Atrophy        |                                              2                           |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                        1  2                 1           2|      7  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |       2        2        2     3        1  2  2                 3     2   |     17  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  A  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +  +  +  +|  38        |
      Atrophy                              |                            4                                             |      1  4.0|
      Hemorrhage                           |                            4                                             |      1  4.0|
      Lens, Cataract                       |          2                                                               |      1  2.0|
      Retina, Vacuolization Cytoplasmic    | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |                                                                          |      1     |
      Mineralization                       |                                                                2         |      1  2.0|
      Nephropathy, Chronic                 | 2  2  2  2  2  1  2  2  2  2  1  2     2  2  2  2  2  2  1  2  2  3  1  1|     47  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|             
                                           | 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  A  M  +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Infarct                              |             2                                                            |             
      Necrosis                             |                                  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                 2              4         |             
      Hematopoietic Cell Proliferation     |                                              3                           |             
      Hyperplasia                          |                                                                          |             
      Infarct                              |       4     2                                                            |             
      Inflammation, Granulomatous          |                                  4                                       |             
      Leukocytosis                         |       3                                                                  |             
      Necrosis                             |          4                                                              4|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinar Cell, Hypertrophy             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                4         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         2|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1  2        2  2     2  1  2  1  2     1  3  2  3  1     2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cytomegaly                           |    2           2           2                             2               |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|             
                                           | 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  M  M  +  +  M  M  M  +  M  +  +  M  +  +  M  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +  +              +                                                |             
      Concretion                           |       4  4                                                               |             
      Inflammation, Suppurative            |          4              4                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +            |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         3        3                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                 4                        |             
      Inflammation, Suppurative            |                         3        2                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                   2                        |             
      Mineralization                       | 2                                               3                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                  4                                       |             
      Mesenteric, Angiectasis              |                   4                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|             
                                           | 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                             4            |             
      Inflammation, Suppurative            |                                  4                          4            |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                      +      |             
      Hemorrhage                           |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2        3  2     2     2  2  2              2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                           4                              |             
      Leukocytosis                         |       3                                                                  |             
      Alveolus, Hyperplasia                |    1                                         2                           |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                           4                              |             
      Alveolus, Inflammation, Suppurative  |                                              1                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   2      |             
      Inflammation, Suppurative            |                                           3                 1     2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2                                                                     |             
      Respiratory Epithelium, Hyperplasia  |                                           1                              |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                  1        1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | I  +  A  I  +  +  +  +  I  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Retina, Vacuolization Cytoplasmic    |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +                                                     +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 0| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 3| 4| 2|             
                                           | 9| 9| 7| 7| 9| 9| 9| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy, Chronic                 |    1        2  1  3  1  2  1  2     1  2     2  2  2  1  1  2  2  2  2  3|             
      Pelvis, Inflammation, Suppurative    |                         4        3           2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  4           2                           |             
      Inflammation, Suppurative            |                         3        4           4                           |             
      Metaplasia, Squamous                 |                                  3                                       |             
      Ulcer                                |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  M  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|  39        |
      Infarct                              |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  M  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                   3      |      1  3.0|
      Clear Cell Focus                     |                                                                          |      2  3.0|
      Hematopoietic Cell Proliferation     |                                  2                                       |      2  2.5|
      Hyperplasia                          |                      3                                               3   |      2  3.0|
      Infarct                              |                                                                          |      2  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Leukocytosis                         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinar Cell, Hypertrophy             |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acanthosis                           |                                                    1                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                         3                                                |      2  2.5|
      Inflammation, Suppurative            |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Hyperplasia                 | 2     2  2  2  2  1  2  1  2        2  2  2  2  2  1     1  2  1  1  2  2|     41  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                               X                                          |      1     |
      Cytomegaly                           | 3        2     2  2  1                          2                        |     10  2.0|
      Hyperplasia                          | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  +  +  M  +  M  +  +  M  M  +  +  +  M  +  M  M  M  M  M  M  M|  20        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |                            2        2                                   2|      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  A  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Suppurative            |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                   +              +                                       |   5        |
      Concretion                           |                                                                          |      2  4.0|
      Inflammation, Suppurative            |                   4              4                                       |      4  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +     +                                               +|   4        |
      Cyst                                 |                         X                                               X|      2     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                  2                                      3|      4  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                  3                                       |      3  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                            4        3  4     2     1           1  2      |      9  2.3|
      Mineralization                       |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |                                     2        2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inguinal, Hematopoietic Cell         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation                    |                                                                          |      1  4.0|
      Mesenteric, Angiectasis              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |             2                                      3                     |      2  2.5|
      Fibrosis                             |             3                                                            |      1  3.0|
      Hematopoietic Cell Proliferation     |                                  3           3                           |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  M  +  +  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  A  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                   4                                                     4|      4  4.0|
      Ulcer                                |                                  2                                      3|      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       | 1              1           2  2        2     2              1     2  2   |     17  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Leukocytosis                         |                                  3                                       |      2  3.0|
      Alveolus, Hyperplasia                |                               2        3           2                 2   |      6  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      2                                                   |      2  3.0|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 0| 4| 7| 7| 7| 6| 7| 6| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 8| 4| 4| 4| 9| 4| 8| 4| 4| 9| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4|            |
                                           | 9| 3| 3| 9| 9| 9| 3| 9| 5| 9| 9| 6| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                      2   |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  M  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Cornea, Inflammation, Suppurative    |                                                                      2   |      1  2.0|
      Retina, Vacuolization Cytoplasmic    | 1                                                  1              1      |      3  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                            +              +   |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                  4                                       |      1  4.0|
      Nephropathy, Chronic                 | 2     2  2  2  2  2  2  3  2  2     2  2  1  2  3  1  3  2  2  2  2  2  2|     43  1.9|
      Pelvis, Inflammation, Suppurative    |                                                                         3|      4  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                1                                                         |      3  2.3|
      Inflammation, Suppurative            |                                  3                                      4|      5  3.6|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 0| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    A     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  A                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  M                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A     A  +                    +                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A     A  M                    +                                       |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +        +     +     +     +                    +            |             
      Hematopoietic Cell Proliferation     |          3                                                               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Artery, Thrombosis                   |                            2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  I  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          3                                                               |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +                    +                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +                    +                                       |             
      Capsule, Hyperplasia                 |          2  2                    2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M     M  M                    M                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +                    +                                       |             
      Follicular Cell, Hyperplasia         |    2        2                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 0| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                    +                          +               |             
      Cyst                                 |                               X                          X               |             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |          4                                               3               |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +  +                    +                                       |             
      Inflammation, Suppurative            |          3                                                               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +     +  +              +     +                                       |             
      Dilatation                           |                                                                          |             
      Inflammation, Suppurative            |          3                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +  +                    +                                       |             
      Atrophy                              |             3                                                            |             
      Inflammation, Suppurative            |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +                    +                                       |             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +                    +                                       |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |          4                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          M  M                    +                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +                    +                                       |             
      Hematopoietic Cell Proliferation     |          3                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     M  +                    +                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M        M                    M                                       |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +           +     +  +                                +      |             
      Inflammation, Suppurative            |          4  4                 2                                          |             
      Ulcer                                |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +                    +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +                    +                                       |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +     +  +                    +                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 5| 5| 0| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                                           | 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukocytosis                         |          2                                                               |             
      Alveolus, Hyperplasia                |                                     2                 3                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                            2                                             |             
      Inflammation, Suppurative            | 2  2     2  4     1  2     2  1        1                                1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                       2                  |             
      Respiratory Epithelium, Hyperplasia  |    2     3  2           1  1                                             |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2  2     3  2     1     2                                   2           2|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +                    +                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          4                                                               |             
      Nephropathy, Chronic                 | 1  2  1     1     1  1  2  1  1     1  1  1     1  1  1  1  1  1  1  1  1|             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +                    +                                       |             
      Dilatation                           |             3                                                            |             
      Hyperplasia                          |    1     3                                                               |             
      Inflammation, Suppurative            |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 8| 5| 5| 1| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 5| 2| 2| 3| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +                                A        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +                                A        A        +      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +                                A        A        +      |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +                                A        A        +      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +                                A        A        +      |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +                                A        A        +      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                A                 +              A        A        +      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                A                 +              A        A        +      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                A                                A        A        +      |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                A                                A        A        +      |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +     +        +  +           +     +  A     +  +        +  +  +|  19        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia                          |                         3              2     3                           |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Artery, Thrombosis                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +                                M        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +                                A        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |    1                                                                     |      1  1.0|
      Epithelium, Hyperplasia              |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +                                +        +        +      |   8        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +                                A        +        +      |   7        |
      Capsule, Hyperplasia                 |                                                          2               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +                                A        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +                                A        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +                                M        +        +      |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M                                M        M        +      |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +                                A        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +                                A        +        +      |   7        |
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 8| 5| 5| 1| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 5| 2| 2| 3| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +                                A        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                         +|   1        |
      Inflammation, Suppurative            |                                                                         4|      1  4.0|
      Necrosis                             |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +                                            +            |   5        |
      Cyst                                 |                                                             1            |      3  1.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                             2            |      1  2.0|
      Inflammation, Suppurative            |                4                                                         |      3  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +                                A        +        +      |   7        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +     +                                   +        +      |   9        |
      Dilatation                           |                      3                                                   |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                +                                A        +        +      |   7        |
      Atrophy                              |                1                                                         |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +                                A        +        +      |   7        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                    +           A        +     +  +      |   9        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                     3                                    |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                                                 A        +        M      |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +                                A        +        +      |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +                    +           M        +     +  M      |   8        |
      Hematopoietic Cell Proliferation     |                                     3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                M                                M        +        +      |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M                                M        M        M      |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +     +                 +        A        +  +     +      |  13        |
      Inflammation, Suppurative            |                                                                          |      3  3.3|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 5| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 5| 5| 8| 5| 5| 1| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| 5| 2| 2| 3| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +                                +        +        +      |   8        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +                                A        +        +      |   7        |
      Mineralization                       |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +                                A        +        +      |   7        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Leukocytosis                         |                                                                          |      1  2.0|
      Alveolus, Hyperplasia                |                                                             2            |      3  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +|  47        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                2        1                    1     1              2     2|     16  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                         1  1     1                                       |      8  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                         2  1                       1                    2|     12  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +                                A        +        +      |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Nephropathy, Chronic                 |    2     1  1     1  1  1  2  1  1  1  1  1  1     1  2     1  1     1  2|     40  1.2|
      Pelvis, Inflammation, Suppurative    |                                              2                 2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +                                A        A        +     +|   7        |
      Dilatation                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                         4|      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  A  A  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Developmental Malformation           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              1                           |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Hyperplasia                          |    3                                            4                        |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                                        1                                 |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Inflammation, Suppurative            |          1                                                               |             
      Epithelium, Hyperplasia              |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  2     2  2  2  1  2     1  2           1  2           2  1  2     2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Cytomegaly                           |    2                                         2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Karyomegaly                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  M  +  M  M  M  M  +  M  +  +  M  M  M  M  M  +  M|             
      Cyst                                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
      Inflammation, Suppurative            |                                           2                              |             
      Follicular Cell, Hyperplasia         |    2                    1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
      Inflammation, Suppurative            |                                        4                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                                  +        +         |             
      Cyst                                 |                                                       X                  |             
      Inflammation, Suppurative            |    4                                                           4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            4           3                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    4                                                                     |             
      Inflammation, Suppurative            |                            4                                   3         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                2                             2     3        1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            4                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |    4                       4           4                       4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       2                    2  2     2     2  2        2  2  2  2        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Alveolus, Hyperplasia                |          3                                                               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2           4                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3  2     2     2     2     3     1     2  2                    2     1   |             
      Olfactory Epithelium, Atrophy        |                               1                                          |             
      Respiratory Epithelium, Hyperplasia  |          1     2           1     1        2           2        1     1  1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2  2     2     2     2  2              2  2                    2  2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  I  +  +  A  +  +|             
      Retina, Vacuolization Cytoplasmic    |       2     1                                1                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +           +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X        X                                                |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Suppurative            |                                        4                                 |             
      Mineralization                       |                      3                          2                        |             
      Nephropathy, Chronic                 | 2  2  2  2  2  2  2  3  2  2  2  1  1  2  2  2  3  1  2  2  1  2  2  2  2|             
      Artery, Inflammation                 |    2                                                                     |             
      Pelvis, Inflammation, Suppurative    |                                                                4         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                3         |             
      Hyperplasia                          |                1                                1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 3| 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1.5 MG/                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                            4           4                       4         |             
      Ulcer                                |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  A  +  +  M  A  +  +  +  +  +  +  +  +  +|  44        |
      Developmental Malformation           |                                                 X                        |      1     |
      Hyperplasia                          |                                                 4                        |      1  4.0|
      Inflammation, Suppurative            |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                      2   |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      2  3.5|
      Infarct                              |                                                          2               |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Leukocytosis                         |                                              4                           |      1  4.0|
      Necrosis                             |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 |    2     2     1        2  2        2  2  1  2  2  1  2  2  3  1  2  2  2|     34  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cytomegaly                           |                         2        2  2                    3               |      6  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Karyomegaly                          |          3                                                               |      1  3.0|
      Vacuolization Cytoplasmic            |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  M  +  M  M  M  +  +  M  +  M  M  M  M  M  +  +  +  +|  24        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  I  +  +|  46        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |          2  2                          1  3                              |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                    +                     |   4        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Suppurative            |                                                    4                     |      3  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           | 4                                                                        |      2  4.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 4                                                                        |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                  3           3           3     3        3|      6  3.0|
      Thrombosis                           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  M  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  4.0|
      Hemorrhage                           |                                              4                           |      1  4.0|
      Inflammation, Suppurative            |                                              4                       4   |      6  4.0|
      Ulcer                                |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                   2                          2           2  2           2|     16  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              3                           |      1  3.0|
      Leukocytosis                         |                   2                          4                           |      2  3.0|
      Alveolus, Hyperplasia                |                                                          4               |      2  3.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                             4     4      |      4  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 3  2     2  3           2  1           2        2        2  1     3  3   |     23  2.1|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Respiratory Epithelium, Hyperplasia  | 1           2                          2                                 |     12  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 3        2  3     1     3  1     2     2  2     2           2     2  2  2|     24  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +  I  +  +  +  +  +  +  +|  43        |
      Retina, Vacuolization Cytoplasmic    |    1        1                                                            |      5  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05096-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:52:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 0| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 8| 5| 5| 5| 7| 5| 5| 5| 4| 5| 9| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 0| 0| 0| 0| 0| 9| 1| 0| 0| 0| 1| 0| 0| 0| 5| 0| 2| 0| 0| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1.5 MG/                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          X                                X                              |      4     |
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Polymorphonuclear                |                                              4                           |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      2  2.5|
      Nephropathy, Chronic                 | 2  2  2  2  2  2  2     1  2  2  2  2  2  3     2     2  2  2  2  2  2  2|     47  2.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                         2                                                |      3  1.3|
      Inflammation, Suppurative            |                                                                          |      3  4.0|
      Ulcer                                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 425145-425145/425145


--multipart-boundary--