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https://ntp.niehs.nih.gov/go/1178

TDMS Study 05096-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/13/94   
EXP: 05096            O-CHLOROBENZALMALONONITRILE (CS-2)       TIME: 05:27:08   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55118    
CONT: N01-ES-38061                                             CAS: 2698-41-1   
PATHOLOGIST: R. RENNE                        S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/13/94  
EXP: 05096            O-CHLOROBENZALMALONONITRILE (CS-2)       TIME: 05:27:08  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55118   
CONT: N01-ES-38061                                             CAS: 2698-41-1  
PATHOLOGIST: R. RENNE                        S. EUSTIS                         

                        O-CHLOROBENZALMALONONITRILE (CS-2)


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 749 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      43    196   440   483   609   665   685   693   707   720                 |
 |      737   737                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.75 MG/M3                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 8      CENSORED DEATHS 0    TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      374   513   527   562   585   608   657   737                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.5 MG/ M3                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      92    381   511   545   562   571   599   693   710   713                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                        O-CHLOROBENZALMALONONITRILE (CS-2)


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 749 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   749 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.0  98.0  96.0  96.0  96.0  92.0  92.0  92.0  88.0  76.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.75 MG/M3 |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  90.0  86.0  84.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.5 MG/ M3 |   100.0  98.0  98.0  98.0  96.0  96.0  92.0  86.0  86.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          0.75 MG/M3       1.5 MG/ M3    |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       76.0%            84.0%            80.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.746N         P=0.475N         P=0.837N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       559.6            570.4            537.7         |
 |NATURAL DEATHS (C)      |       (66.1)           (38.0)           (59.1)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       703.5            720.4            706.7         |
 |(STANDARD ERROR)        |       (19.2)           (11.0)           (16.6)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                        O-CHLOROBENZALMALONONITRILE (CS-2)


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 748 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      263   381   451   464   552   615   625   668   679   692                 |
 |      693   709   709   715   723   727   740                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 0.75 MG/M3                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      52    267   639   658   700   700   709   709   729   735                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1.5 MG/ M3                               |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      215   543   615   693   697   709   709   709   736   745                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                        O-CHLOROBENZALMALONONITRILE (CS-2)


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 748 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   748 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  98.0  96.0  92.0  92.0  90.0  86.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0.75 MG/M3 |    98.0  98.0  96.0  96.0  96.0  96.0  96.0  96.0  92.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1.5 MG/ M3 |   100.0 100.0  98.0  98.0  98.0  98.0  96.0  96.0  94.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          0.75 MG/M3       1.5 MG/ M3    |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.0%            80.0%            80.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.109N         P=0.157N         P=0.147N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       612.1            589.8            637.1         |
 |NATURAL DEATHS (C)      |       (34.2)           (74.1)           (50.7)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       701.8            716.4            725.8         |
 |(STANDARD ERROR)        |       (14.7)           (16.8)           (11.6)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                 O-CHLOROBENZALMALONONITRILE (CS-2)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.75 MG/M3       = 2
                                                        1.5 MG/ M3       = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

           |
           |
     100.0 +  1      1      3                                       2
           |
           |
           |         1      3             1                         23                  2
      97.5 +
           |
           |                              1                          3       1         32 2
           |
      95.0 +
           |
           |                                                                 1     1   3  2 3  2
           |
   P  92.5 +
   E       |                                                                       1        3  2  2  1
   R       |
   C       |
   E  90.0 +                                                                                   33 2  1       1
   N       |
   T       |
           |                                                                                    3   32      21  1
   S  87.5 +
   U       |
   R       |                                                                                        3       2   11      2
   V       |
   I  85.0 +
   V       |
   A       |                                                                                                     1 13   22
   L       |
      82.5 +
           |                                                                                                       1 1
           |
           |
      80.0 +                                                                                                        31  13
           |
           |
           |
      77.5 +
           |
           |                                                                                                            11
           |
      75.0 +
           |
           ---+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+--
              0      7     14     21     28     35     42     49     56     63     70     77     84     91     98     105    112

                                                                    WEEK

NOTE: 6 obs hidden.

                                                 O-CHLOROBENZALMALONONITRILE (CS-2)
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        0.75 MG/M3       = 2
                                                        1.5 MG/ M3       = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1        2                        3       1
      |
      |          2                        3       12                 1                        3
      |                                            2                 1          1             3          3   2
   95 +
      |                                                                         1 1                      3   2 2     3
P     |                                                                           1            1               2     32
E     |
R  90 +                                                                                        1         1            3 3
C     |
E     |                                                                                                  1 1          2 2
N     |                                                                                                    1      1
T  85 +
      |                                                                                                           11    2   23
S     |                                                                                                            1 1       33
U     |
R  80 +                                                                                                                     2 2
V     |
I     |                                                                                                              1  1
V     |
A  75 +
L     |                                                                                                                 11
      |                                                                                                                  11
      |
   70 +
      |
      |                                                                                                                   1  1
      |                                                                                                                      11
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 5 obs hidden.

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