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https://ntp.niehs.nih.gov/go/840

TDMS Study 05096-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 0-CHLOROBENZALMALONONITRILE (CS-2)


NTP Experiment-Test: 05096-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04




       Facility:  Battelle Northwest

       Chemical CAS #:  2698-41-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                               7            5            9            4                                     
    Moribund                                          23           21           12           19                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           24           29           27                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (40)         (20)         (10)         (46)                                   
      Inflammation, Suppurative                                     1 (5%)                                                          
      Parasite Metazoan                                4 (10%)      1 (5%)       1 (10%)      6 (13%)                               
   Intestine Large, Colon                             (45)         (20)         (15)         (47)                                   
      Parasite Metazoan                                2 (4%)       1 (5%)       2 (13%)      5 (11%)                               
   Intestine Large, Rectum                            (47)         (23)         (14)         (43)                                   
      Parasite Metazoan                                1 (2%)       1 (4%)                    3 (7%)                                
   Intestine Small, Duodenum                          (43)         (24)         (15)         (46)                                   
      Ulcer                                                                      1 (7%)       1 (2%)                                
   Intestine Small, Ileum                             (31)         (18)         (4)          (40)                                   
      Hyperplasia, Lymphoid                            1 (3%)                                 3 (8%)                                
      Parasite Metazoan                                                                       1 (3%)                                
   Intestine Small, Jejunum                           (37)         (13)         (7)          (38)                                   
      Hyperplasia, Lymphoid                                                                   1 (3%)                                
   Liver                                              (49)         (50)         (50)         (50)                                   
      Angiectasis                                      5 (10%)      6 (12%)      6 (12%)      7 (14%)                               
      Basophilic Focus                                25 (51%)     18 (36%)     24 (48%)     22 (44%)                               
      Clear Cell Focus                                 2 (4%)       2 (4%)                    1 (2%)                                
      Congestion                                       1 (2%)                    1 (2%)       1 (2%)                                
      Degeneration, Fatty                             18 (37%)     19 (38%)      8 (16%)     11 (22%)                               
      Eosinophilic Focus                                                                      2 (4%)                                
      Hematopoietic Cell Proliferation                 7 (14%)      5 (10%)      9 (18%)      1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       6 (12%)      2 (4%)       8 (16%)     11 (22%)                               
      Hyperplasia                                                   3 (6%)                                                          
      Inflammation, Focal, Granulomatous              23 (47%)     23 (46%)     26 (52%)     28 (56%)                               
      Leukocytosis                                     2 (4%)       1 (2%)                    1 (2%)                                
      Necrosis                                        10 (20%)     13 (26%)      9 (18%)      9 (18%)                               
      Pigmentation, Bile                                                         1 (2%)                                             
      Thrombosis                                                    1 (2%)                    1 (2%)                                
      Bile Duct, Hyperplasia                           8 (16%)     10 (20%)      6 (12%)      8 (16%)                               
   Mesentery                                          (4)          (4)          (2)                                                 
      Fat, Hemorrhage                                  1 (25%)                                                                      
      Fat, Inflammation, Chronic                       3 (75%)      3 (75%)      2 (100%)                                           
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    3 (75%)      3 (75%)      2 (100%)                                           
   Pancreas                                           (49)         (25)         (19)         (50)                                   
      Acinus, Atrophy                                 11 (22%)      3 (12%)      5 (26%)     10 (20%)                               
      Acinus, Fibrosis                                              1 (4%)                                                          
      Acinus, Focal Cellular Change                                 1 (4%)                                                          
      Acinus, Inflammation                                                                    1 (2%)                                
   Pharynx                                            (1)                       (1)                                                 
      Palate, Developmental Malformation                                         1 (100%)                                           
      Palate, Inflammation                             1 (100%)                                                                     
   Salivary Glands                                    (49)         (25)         (19)         (50)                                   
      Inflammation, Chronic                            2 (4%)                                                                       
      Inflammation, Suppurative                       16 (33%)      1 (4%)       3 (16%)     13 (26%)                               
      Duct, Hyperplasia                               22 (45%)      8 (32%)      7 (37%)     25 (50%)                               
   Stomach, Forestomach                               (48)         (33)         (21)         (50)                                   
      Inflammation, Chronic                            3 (6%)       9 (27%)      1 (5%)       4 (8%)                                
      Inflammation, Suppurative                        4 (8%)       2 (6%)       1 (5%)       1 (2%)                                
      Ulcer                                            5 (10%)     10 (30%)      2 (10%)      5 (10%)                               
      Epithelium, Hyperplasia                         10 (21%)     10 (30%)      2 (10%)      7 (14%)                               
   Stomach, Glandular                                 (49)         (31)         (20)         (50)                                   
      Hemorrhage                                       2 (4%)                    1 (5%)       1 (2%)                                
      Inflammation, Chronic                            5 (10%)      4 (13%)                   1 (2%)                                
      Inflammation, Suppurative                        2 (4%)       1 (3%)       1 (5%)       1 (2%)                                
      Pigmentation, Hemosiderin                        1 (2%)       1 (3%)       1 (5%)       1 (2%)                                
      Ulcer                                            9 (18%)      4 (13%)      3 (15%)      3 (6%)                                
      Epithelium, Hyperplasia                          1 (2%)                                 1 (2%)                                
   Tongue                                             (1)          (1)                                                              
      Epithelium, Hyperplasia                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (28)         (21)         (50)                                   
      Cardiomyopathy                                  42 (86%)     21 (75%)     16 (76%)     49 (98%)                               
      Inflammation, Suppurative                                     1 (4%)                                                          
      Mineralization                                                1 (4%)                                                          
      Necrosis                                                      1 (4%)                                                          
      Atrium, Congestion                                            2 (7%)                                                          
      Atrium, Inflammation                                                                    1 (2%)                                
      Atrium, Thrombosis                               3 (6%)       1 (4%)       1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (25)         (23)         (48)                                   
      Degeneration, Fatty                             26 (53%)     12 (48%)      7 (30%)     29 (60%)                               
      Ectopic Tissue                                                                          1 (2%)                                
      Focal Cellular Change                            6 (12%)      2 (8%)                    8 (17%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hematopoietic Cell Proliferation                10 (20%)      4 (16%)      3 (13%)     10 (21%)                               
      Hyperplasia                                      7 (14%)                   3 (13%)      4 (8%)                                
      Necrosis                                         3 (6%)       1 (4%)       1 (4%)                                             
      Thrombosis                                                                 1 (4%)                                             
   Adrenal Gland, Medulla                             (37)         (21)         (18)         (44)                                   
      Hyperplasia                                     10 (27%)      2 (10%)      7 (39%)      8 (18%)                               
      Thrombosis                                                                 1 (6%)                                             
   Islets, Pancreatic                                 (48)         (24)         (20)         (49)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (40)         (22)         (18)         (43)                                   
      Hyperplasia                                      3 (8%)       2 (9%)                    1 (2%)                                
   Pituitary Gland                                    (48)         (44)         (42)         (49)                                   
      Degeneration, Cystic                                          3 (7%)       1 (2%)                                             
      Pars Distalis, Angiectasis                       3 (6%)       2 (5%)                    1 (2%)                                
      Pars Distalis, Cyst                              3 (6%)                                 1 (2%)                                
      Pars Distalis, Hemorrhage                                     2 (5%)                                                          
      Pars Distalis, Hyperplasia                      10 (21%)      6 (14%)      6 (14%)      7 (14%)                               
   Thyroid Gland                                      (48)         (26)         (18)         (50)                                   
      C-Cell, Hyperplasia                             10 (21%)      4 (15%)                   4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (25)         (21)         (48)                                   
      Cyst                                                                                    2 (4%)                                
      Hyperplasia                                      1 (2%)                    1 (5%)       2 (4%)                                
      Inflammation, Suppurative                       11 (23%)      1 (4%)       3 (14%)      7 (15%)                               
      Duct, Hyperplasia                                                                       1 (2%)                                
   Ovary                                              (49)         (49)         (50)         (50)                                   
      Atrophy                                          1 (2%)       2 (4%)       1 (2%)       4 (8%)                                
      Cyst                                             2 (4%)       3 (6%)       1 (2%)       6 (12%)                               
      Hyperplasia                                                                             1 (2%)                                
      Proliferation                                                 1 (2%)                                                          
   Uterus                                             (49)         (31)         (23)         (50)                                   
      Dilatation                                       2 (4%)                                 2 (4%)                                
      Hemorrhage                                                                 1 (4%)       2 (4%)                                
      Hyperplasia, Cystic                              1 (2%)                                 1 (2%)                                
      Submucosa, Hyperplasia                                        1 (3%)                                                          
   Vagina                                                          (1)          (1)                                                 
      Inflammation, Suppurative                                     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (26)         (19)         (49)                                   
      Depletion Cellular                                                                      1 (2%)                                
      Hyperplasia, Neutrophil                                                                 2 (4%)                                
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Myelofibrosis                                    3 (6%)       1 (4%)       1 (5%)       2 (4%)                                
   Lymph Node                                         (49)         (48)         (49)         (50)                                   
      Mediastinal, Inflammation, Focal,                                                                                             
          Granulomatous                                1 (2%)                                                                       
      Mesenteric, Inflammation, Focal,                                                                                              
          Granulomatous                                             1 (2%)                                                          
   Lymph Node, Bronchial                              (47)         (47)         (47)         (46)                                   
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      4 (9%)                    3 (6%)      10 (22%)                               
      Inflammation, Focal, Granulomatous                            1 (2%)       1 (2%)                                             
   Lymph Node, Mandibular                             (45)         (25)         (19)         (47)                                   
      Congestion                                                                              1 (2%)                                
      Hyperplasia                                     15 (33%)      3 (12%)      2 (11%)     19 (40%)                               
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Necrosis                                                                   1 (5%)                                             
   Spleen                                             (49)         (50)         (49)         (50)                                   
      Developmental Malformation                       1 (2%)                                                                       
      Fibrosis                                         5 (10%)      2 (4%)       3 (6%)       5 (10%)                               
      Hematopoietic Cell Proliferation                 6 (12%)      4 (8%)       7 (14%)      2 (4%)                                
      Hemorrhage                                                                 3 (6%)       1 (2%)                                
      Inflammation, Granulomatous                      1 (2%)       1 (2%)                    2 (4%)                                
      Necrosis                                         2 (4%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)       3 (6%)                                                          
      Thrombosis                                                                 3 (6%)                                             
      Capsule, Inflammation, Suppurative                            1 (2%)                                                          
      Capsule, Thrombosis                              1 (2%)                                                                       
   Thymus                                             (44)         (23)         (20)         (47)                                   
      Degeneration, Cystic                                                                    2 (4%)                                
      Inflammation, Chronic                                                      1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (49)         (49)                                   
      Galactocele                                      2 (4%)       3 (6%)                    1 (2%)                                
      Hyperplasia                                      6 (13%)      9 (18%)     10 (20%)     11 (22%)                               
   Skin                                               (50)         (33)         (30)         (50)                                   
      Acanthosis                                                    1 (3%)                                                          
      Cyst Epithelial Inclusion                                                  1 (3%)                                             
      Inflammation, Suppurative                                                  1 (3%)                                             
      Necrosis                                                                   1 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Ulcer                                                         2 (6%)                                                          
      Epidermis, Hyperplasia                                                                  1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    2 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (29)         (21)         (50)                                   
      Fibrous Osteodystrophy                           3 (6%)       1 (3%)                                                          
      Osteopetrosis                                    4 (8%)       2 (7%)       1 (5%)       6 (12%)                               
      Periosteum, Proliferation                                                              18 (36%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (28)         (21)         (50)                                   
      Hemorrhage                                       6 (12%)      4 (14%)      3 (14%)      3 (6%)                                
      Hydrocephalus                                    3 (6%)       1 (4%)                    1 (2%)                                
      Necrosis                                                                                1 (2%)                                
      Meninges, Inflammation, Suppurative              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (24)         (18)         (50)                                   
      Inflammation                                                               2 (11%)                                            
      Inflammation, Suppurative                       22 (45%)     10 (42%)      6 (33%)     22 (44%)                               
      Metaplasia, Squamous                             1 (2%)       1 (4%)                    2 (4%)                                
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Lung                                               (49)         (50)         (50)         (50)                                   
      Congestion                                       2 (4%)       4 (8%)       5 (10%)      3 (6%)                                
      Edema                                                                      1 (2%)                                             
      Hemorrhage                                       3 (6%)       1 (2%)       3 (6%)       8 (16%)                               
      Infiltration Cellular, Mixed Cell                3 (6%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic, Focal                    16 (33%)      7 (14%)     24 (48%)     32 (64%)                               
      Inflammation, Focal, Granulomatous                                                      2 (4%)                                
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 4 (8%)       4 (8%)       1 (2%)       5 (10%)                               
      Alveolus, Infiltration Cellular, Histiocyte      6 (12%)      4 (8%)       5 (10%)     20 (40%)                               
      Mediastinum, Inflammation, Chronic               1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                            18 (37%)     10 (20%)     21 (42%)     23 (46%)                               
   Nose                                               (49)         (49)         (49)         (50)                                   
      Inflammation                                    37 (76%)     21 (43%)     34 (69%)     48 (96%)                               
      Inflammation, Suppurative                       46 (94%)     30 (61%)     43 (88%)     47 (94%)                               
      Thrombosis                                       8 (16%)      5 (10%)      3 (6%)                                             
      Nares, Inflammation, Chronic                     1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasolacrimal Duct, Inflammation, Suppurative    14 (29%)     13 (27%)     11 (22%)      7 (14%)                               
      Olfactory Epithelium, Degeneration                                         1 (2%)      23 (46%)                               
      Olfactory Epithelium, Metaplasia                 3 (6%)       1 (2%)       1 (2%)      15 (30%)                               
      Olfactory Epithelium, Metaplasia, Squamous                                              3 (6%)                                
      Respiratory Epithelium, Hyperplasia              3 (6%)       3 (6%)       6 (12%)     46 (92%)                               
      Respiratory Epithelium, Metaplasia, Squamous                  2 (4%)       5 (10%)     49 (98%)                               
      Submucosa, Hyperplasia                                                                  5 (10%)                               
      Vomeronasal Organ, Inflammation, Suppurative    12 (24%)      4 (8%)       6 (12%)     12 (24%)                               
   Trachea                                            (48)         (25)         (18)         (48)                                   
      Inflammation, Suppurative                        3 (6%)       2 (8%)       2 (11%)      3 (6%)                                
      Epithelium, Hyperplasia                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
   Eye                                                (48)         (5)          (3)          (49)                                   
      Synechia                                                      2 (40%)                   3 (6%)                                
      Anterior Chamber, Inflammation, Suppurative      1 (2%)                                                                       
      Cornea, Hyperplasia                                                                     1 (2%)                                
      Cornea, Inflammation, Suppurative                                          1 (33%)      3 (6%)                                
      Lens, Degeneration                               5 (10%)      3 (60%)      1 (33%)      5 (10%)                               
      Lens, Mineralization                                                                    2 (4%)                                
      Retina, Degeneration                             4 (8%)       3 (60%)      1 (33%)      6 (12%)                               
   Harderian Gland                                    (4)          (1)                       (1)                                    
      Inflammation, Suppurative                        4 (100%)                                                                     
      Metaplasia, Squamous                                          1 (100%)                  1 (100%)                              
   Lacrimal Gland                                     (3)          (3)          (7)          (7)                                    
      Inflammation, Suppurative                        1 (33%)      1 (33%)                                                         
      Acinus, Atrophy                                  3 (100%)     3 (100%)     7 (100%)     7 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (37)         (30)         (50)                                   
      Cyst                                                                       1 (3%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       1 (3%)                                                          
      Inflammation, Suppurative                                                  1 (3%)                                             
      Mineralization                                   1 (2%)                    1 (3%)                                             
      Nephropathy                                     45 (92%)     34 (92%)     29 (97%)     48 (96%)                               
      Artery, Hyperplasia                                           1 (3%)                                                          
      Capsule, Inflammation                                         1 (3%)                                                          
      Renal Tubule, Hyperplasia                        3 (6%)       2 (5%)       1 (3%)       1 (2%)                                
   Urinary Bladder                                    (47)         (24)         (20)         (48)                                   
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Suppurative                                                  1 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                                                    1 (2%)                                
      Vein, Ectasia                                                                           1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           27           21           20                                     
    Dead                                               5            6            8            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           17           21           26                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (33)         (28)         (48)                                   
      Inflammation, Suppurative                                                  1 (4%)                                             
   Intestine Large, Cecum                             (44)         (26)         (21)         (44)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                        2 (5%)                                                                       
      Parasite Metazoan                                4 (9%)                    1 (5%)       6 (14%)                               
   Intestine Large, Colon                             (48)         (32)         (24)         (46)                                   
      Parasite Metazoan                                6 (13%)      7 (22%)      3 (13%)      8 (17%)                               
   Intestine Large, Rectum                            (45)         (30)         (20)         (45)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                3 (7%)       2 (7%)                    4 (9%)                                
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Ileum                             (42)         (22)         (18)         (43)                                   
      Hyperplasia, Lymphoid                            9 (21%)                                4 (9%)                                
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (41)         (18)         (12)         (39)                                   
      Parasite Metazoan                                                                       1 (3%)                                
   Liver                                              (50)         (50)         (49)         (50)                                   
      Angiectasis                                      3 (6%)       5 (10%)      8 (16%)      3 (6%)                                
      Basophilic Focus                                17 (34%)      7 (14%)     10 (20%)     23 (46%)                               
      Clear Cell Focus                                 9 (18%)      2 (4%)       3 (6%)       4 (8%)                                
      Congestion                                                                              1 (2%)                                
      Degeneration                                     3 (6%)                    2 (4%)                                             
      Degeneration, Cystic                             1 (2%)       7 (14%)      7 (14%)      3 (6%)                                
      Degeneration, Fatty                             16 (32%)     24 (48%)     11 (22%)     10 (20%)                               
      Eosinophilic Focus                                                                      1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       5 (10%)      5 (10%)                               
      Hepatodiaphragmatic Nodule                       7 (14%)      5 (10%)      7 (14%)      9 (18%)                               
      Hyperplasia                                                   1 (2%)       2 (4%)                                             
      Inflammation, Focal, Granulomatous              14 (28%)     13 (26%)      8 (16%)      8 (16%)                               
      Leukocytosis                                     5 (10%)      1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                         8 (16%)     10 (20%)     11 (22%)      7 (14%)                               
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Hyperplasia                          40 (80%)     32 (64%)     31 (63%)     31 (62%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (5)          (3)          (2)          (4)                                    
      Hemorrhage                                                                 1 (50%)                                            
      Fat, Inflammation, Chronic                       2 (40%)      1 (33%)      1 (50%)      2 (50%)                               
      Fat, Necrosis                                    5 (100%)     2 (67%)      1 (50%)      2 (50%)                               
   Pancreas                                           (50)         (33)         (26)         (48)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Thrombosis                                                                 1 (4%)                                             
      Acinus, Atrophy                                 22 (44%)     10 (30%)      9 (35%)     15 (31%)                               
      Acinus, Necrosis                                                                        1 (2%)                                
   Pharynx                                            (1)          (1)          (2)          (4)                                    
      Palate, Cyst                                                                            1 (25%)                               
      Palate, Developmental Malformation                                                      2 (50%)                               
      Palate, Inflammation                                                       1 (50%)                                            
      Palate, Inflammation, Chronic                                 1 (100%)                  1 (25%)                               
   Salivary Glands                                    (49)         (33)         (27)         (49)                                   
      Inflammation, Suppurative                       12 (24%)      6 (18%)      5 (19%)     13 (27%)                               
      Duct, Hyperplasia                               15 (31%)     16 (48%)      9 (33%)     16 (33%)                               
   Stomach, Forestomach                               (50)         (33)         (28)         (50)                                   
      Inflammation, Chronic                           13 (26%)      9 (27%)      3 (11%)      3 (6%)                                
      Inflammation, Suppurative                        1 (2%)                    1 (4%)       1 (2%)                                
      Mineralization                                                             1 (4%)                                             
      Ulcer                                           12 (24%)      7 (21%)      2 (7%)       4 (8%)                                
      Epithelium, Hyperplasia                         13 (26%)     11 (33%)      4 (14%)      4 (8%)                                
   Stomach, Glandular                                 (50)         (32)         (28)         (49)                                   
      Ectopic Tissue                                                             1 (4%)                                             
      Hemorrhage                                                    1 (3%)                    2 (4%)                                
      Infiltration Cellular, Eosinophil                1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       5 (16%)      1 (4%)                                             
      Inflammation, Suppurative                        8 (16%)      4 (13%)                   1 (2%)                                
      Mineralization                                   4 (8%)                    1 (4%)       1 (2%)                                
      Pigmentation, Hemosiderin                                     3 (9%)       1 (4%)                                             
      Ulcer                                            8 (16%)      9 (28%)      2 (7%)       3 (6%)                                
   Tooth                                                           (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (1)                                                 
      Mineralization                                   3 (100%)                  1 (100%)                                           
   Heart                                              (50)         (35)         (30)         (50)                                   
      Cardiomyopathy                                  47 (94%)     34 (97%)     30 (100%)    48 (96%)                               
      Mineralization                                   1 (2%)                    1 (3%)                                             
      Atrium, Congestion                                            1 (3%)       1 (3%)                                             
      Atrium, Thrombosis                               3 (6%)       1 (3%)       5 (17%)      3 (6%)                                
      Ventricle, Thrombosis                                                      1 (3%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (48)         (49)                                   
      Degeneration, Fatty                             22 (44%)     26 (52%)     21 (44%)     24 (49%)                               
      Focal Cellular Change                            3 (6%)       1 (2%)       2 (4%)       2 (4%)                                
      Hematopoietic Cell Proliferation                 6 (12%)      5 (10%)      4 (8%)      16 (33%)                               
      Hyperplasia                                      4 (8%)       3 (6%)       2 (4%)       2 (4%)                                
      Hypertrophy                                      1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (42)         (46)         (47)         (38)                                   
      Hematopoietic Cell Proliferation                                                        1 (3%)                                
      Hyperplasia                                     15 (36%)     19 (41%)     19 (40%)     17 (45%)                               
      Necrosis                                         1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (36)         (27)         (48)                                   
      Hyperplasia                                      3 (6%)       1 (3%)                    3 (6%)                                
   Parathyroid Gland                                  (42)         (32)         (27)         (41)                                   
      Hyperplasia                                      2 (5%)       4 (13%)      3 (11%)      3 (7%)                                
      Thrombosis                                                                 1 (4%)                                             
   Pituitary Gland                                    (47)         (43)         (40)         (47)                                   
      Pars Distalis, Angiectasis                                    1 (2%)                                                          
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       3 (8%)       1 (2%)                                
      Pars Distalis, Hemorrhage                        1 (2%)                    1 (3%)       1 (2%)                                
      Pars Distalis, Hyperplasia                      12 (26%)      5 (12%)      9 (23%)     12 (26%)                               
      Pars Distalis, Inflammation, Suppurative         1 (2%)                                                                       
      Pars Intermedia, Hyperplasia                                                            1 (2%)                                
   Thyroid Gland                                      (48)         (49)         (46)         (48)                                   
      C-Cell, Hyperplasia                              8 (17%)      5 (10%)     10 (22%)      9 (19%)                               
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                                                        (1)          (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
   Preputial Gland                                    (50)         (48)         (46)         (50)                                   
      Cyst                                             2 (4%)                    1 (2%)                                             
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Squamous                                                                   1 (2%)                                
      Inflammation, Suppurative                        9 (18%)      8 (17%)     14 (30%)     10 (20%)                               
   Prostate                                           (50)         (34)         (27)         (50)                                   
      Hyperplasia                                      6 (12%)      1 (3%)       1 (4%)      10 (20%)                               
      Inflammation, Suppurative                       23 (46%)     21 (62%)     14 (52%)     18 (36%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Seminal Vesicle                                    (7)          (3)          (6)          (8)                                    
      Dilatation                                                    2 (67%)      2 (33%)      1 (13%)                               
      Inflammation, Suppurative                        6 (86%)      1 (33%)      2 (33%)      6 (75%)                               
   Testes                                             (50)         (47)         (50)         (50)                                   
      Atrophy                                         14 (28%)     14 (30%)     17 (34%)     14 (28%)                               
      Necrosis                                         1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   6 (12%)     10 (21%)     11 (22%)      6 (12%)                               
      Perivascular, Inflammation                       5 (10%)      2 (4%)       4 (8%)       6 (12%)                               
      Tunic, Hyperplasia                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (33)         (26)         (49)                                   
      Depletion Cellular                               1 (2%)                                                                       
      Hyperplasia, Neutrophil                          1 (2%)                                                                       
      Myelofibrosis                                    2 (4%)       4 (12%)      2 (8%)       2 (4%)                                
   Lymph Node                                         (50)         (35)         (30)         (49)                                   
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Mediastinal, Congestion                                       1 (3%)                                                          
      Mesenteric, Angiectasis                                       1 (3%)                                                          
      Mesenteric, Inflammation, Focal,                                                                                              
          Granulomatous                                1 (2%)       1 (3%)                                                          
      Mesenteric, Pigmentation, Hemosiderin            1 (2%)                                                                       
      Renal, Congestion                                1 (2%)                                                                       
      Renal, Hyperplasia                               2 (4%)                                                                       
   Lymph Node, Bronchial                              (50)         (29)         (25)         (47)                                   
      Hyperplasia                                      5 (10%)                   1 (4%)       8 (17%)                               
      Inflammation, Focal, Granulomatous               1 (2%)                                 1 (2%)                                
      Inflammation, Suppurative                                                  1 (4%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Lymph Node, Mandibular                             (47)         (27)         (28)         (46)                                   
      Fibrosis                                                                   1 (4%)                                             
      Hyperplasia                                     21 (45%)      6 (22%)      1 (4%)      18 (39%)                               
      Inflammation, Focal, Granulomatous                                                      2 (4%)                                
   Spleen                                             (50)         (49)         (49)         (50)                                   
      Ectopic Tissue                                   1 (2%)                                                                       
      Fibrosis                                         3 (6%)       6 (12%)      7 (14%)     10 (20%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       1 (2%)       7 (14%)                               
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)       1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Necrosis                                         3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Thrombosis                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (21)         (10)         (12)         (24)                                   
      Galactocele                                      7 (33%)      6 (60%)      2 (17%)      8 (33%)                               
      Hyperplasia                                      6 (29%)      1 (10%)      6 (50%)      8 (33%)                               
      Inflammation, Chronic                                         2 (20%)                   1 (4%)                                
   Skin                                               (49)         (32)         (30)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Cyst Epithelial Inclusion                                                  1 (3%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Epidermis, Hyperplasia                                        1 (3%)                                                          
      Subcutaneous Tissue, Fibrosis                                              1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (33)         (29)         (50)                                   
      Fibrous Osteodystrophy                           5 (10%)      2 (6%)       1 (3%)       2 (4%)                                
      Periosteum, Proliferation                        3 (6%)       1 (3%)                   15 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (33)         (30)         (50)                                   
      Hemorrhage                                       2 (4%)       2 (6%)       4 (13%)      3 (6%)                                
      Hydrocephalus                                                                           1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis                                                      1 (3%)                                                          
      Meninges, Pigmentation, Hemosiderin              1 (2%)                                                                       
      Meninges, Thrombosis                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (30)         (25)         (48)                                   
      Inflammation                                                               1 (4%)                                             
      Inflammation, Suppurative                       22 (45%)     19 (63%)     13 (52%)     22 (46%)                               
      Metaplasia, Squamous                                                       1 (4%)       3 (6%)                                
      Epithelium, Hyperplasia                          1 (2%)                    1 (4%)                                             
   Lung                                               (50)         (49)         (50)         (50)                                   
      Congestion                                       1 (2%)       2 (4%)       2 (4%)       5 (10%)                               
      Edema                                                                      1 (2%)                                             
      Hemorrhage                                       3 (6%)       1 (2%)       3 (6%)       5 (10%)                               
      Inflammation, Chronic, Focal                    13 (26%)     11 (22%)     14 (28%)      9 (18%)                               
      Inflammation, Focal, Granulomatous               1 (2%)                                                                       
      Mineralization                                   2 (4%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 5 (10%)      5 (10%)      4 (8%)       7 (14%)                               
      Alveolus, Infiltration Cellular, Histiocyte      3 (6%)       9 (18%)      6 (12%)      8 (16%)                               
      Peribronchial, Infiltration Cellular,                                                                                         
          Mononuclear Cell                             1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                            18 (36%)     12 (24%)     19 (38%)     24 (48%)                               
   Nose                                               (50)         (50)         (49)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Adenomatous                                      1 (2%)                                                          
      Inflammation                                    28 (56%)     19 (38%)     24 (49%)     48 (96%)                               
      Inflammation, Suppurative                       46 (92%)     45 (90%)     46 (94%)     47 (94%)                               
      Thrombosis                                      11 (22%)     10 (20%)      9 (18%)      1 (2%)                                
      Nasolacrimal Duct, Inflammation, Suppurative    17 (34%)     14 (28%)     14 (29%)     13 (26%)                               
      Olfactory Epithelium, Degeneration               1 (2%)       4 (8%)       3 (6%)      27 (54%)                               
      Olfactory Epithelium, Metaplasia                 2 (4%)       4 (8%)      10 (20%)     13 (26%)                               
      Olfactory Epithelium, Metaplasia, Squamous                                 1 (2%)       6 (12%)                               
      Respiratory Epithelium, Hyperplasia             12 (24%)     11 (22%)     12 (24%)     48 (96%)                               
      Respiratory Epithelium, Metaplasia, Squamous     4 (8%)       5 (10%)      6 (12%)     44 (88%)                               
      Submucosa, Hyperplasia                                                                  3 (6%)                                
      Vomeronasal Organ, Inflammation, Suppurative     3 (6%)       7 (14%)      6 (12%)      8 (16%)                               
   Trachea                                            (49)         (29)         (26)         (47)                                   
      Inflammation, Suppurative                        2 (4%)       3 (10%)      2 (8%)       5 (11%)                               
      Epithelium, Hyperplasia                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (48)         (6)          (4)          (49)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Synechia                                                                   1 (25%)      2 (4%)                                
      Anterior Chamber, Inflammation, Suppurative      3 (6%)       1 (17%)                   3 (6%)                                
      Cornea, Degeneration                             1 (2%)                                 2 (4%)                                
      Cornea, Inflammation, Suppurative                2 (4%)       3 (50%)                   4 (8%)                                
      Cornea, Mineralization                           2 (4%)                                 2 (4%)                                
      Lens, Degeneration                               3 (6%)       3 (50%)                   2 (4%)                                
      Lids, Inflammation, Suppurative                  1 (2%)                                                                       
      Retina, Degeneration                             2 (4%)       3 (50%)                   2 (4%)                                
   Harderian Gland                                    (7)                                    (1)                                    
      Inflammation, Suppurative                        5 (71%)                                                                      
      Metaplasia, Squamous                             1 (14%)                                                                      
      Acinus, Hyperplasia                              1 (14%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05096-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:04  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (44)         (39)         (50)                                   
      Cyst                                                                       2 (5%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                                 1 (3%)                                             
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                                       1 (2%)                                                          
      Inflammation, Suppurative                                     2 (5%)       2 (5%)       2 (4%)                                
      Mineralization                                   1 (2%)       1 (2%)       1 (3%)                                             
      Nephropathy                                     50 (100%)    43 (98%)     39 (100%)    50 (100%)                              
      Pigmentation, Hemosiderin                                     1 (2%)                                                          
      Papilla, Necrosis                                                          1 (3%)                                             
      Pelvis, Epithelium, Hyperplasia                  1 (2%)       2 (5%)                    1 (2%)                                
      Renal Tubule, Hyperplasia                        1 (2%)       6 (14%)      1 (3%)       3 (6%)                                
   Urinary Bladder                                    (49)         (31)         (27)         (49)                                   
      Calculus Gross Observation                                                 1 (4%)                                             
      Calculus Micro Observation Only                                            1 (4%)                                             
      Hemorrhage                                                                 2 (7%)                                             
      Inflammation                                                  1 (3%)                    1 (2%)                                
      Inflammation, Suppurative                        1 (2%)       3 (10%)      4 (15%)                                            
      Transitional Epithelium, Hyperplasia             1 (2%)       2 (6%)       1 (4%)       2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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