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TDMS Study 05096-01 Pathology Tables

NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20




       Facility:  Battelle Northwest

       Chemical CAS #:  2698-41-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  A  +  +  +  +  +  +  A  I  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  I  A  +  +  +  +  +  I  A  +  A  A  +  +  I  +  I  +  A  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
      Peyer's Patch, Leukemia Mononuclear  |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  I  A  +  +  +  +  +  A  A  I  +  A  +  +  I  +  I  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X     X     X  X     X     X                  |             
      Neoplastic Nodule                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Leukemia Mononuclear            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X           X              X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |       X           X  X     X     X              X     X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  I  M  +  M  +  M  +  M  +  M  +  I  +  I  +  +  I  +  +|             
      Leukemia Mononuclear                 |                                                 X     X                  |             
      Pheochromocytoma Benign              |                X                                               X     X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  I  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Adenoma               | X     X     X  X  X     X     X     X  X  X  X                 X  X  X  X|             
      Pars Distalis, Carcinoma             |                                                          X               |             
      Pars Distalis, Leukemia Mononuclear  |       X              X                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      C-Cell, Adenoma                      |                      X                                      X            |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                             X           X               |             
      Duct, Carcinoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |       X              X                          X     X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deciduoma Benign                     |                                                                   X      |             
      Leukemia Mononuclear                 |                      X                          X                        |             
      Polyp Stromal                        |                                                                X     X   |             
      Polyp Stromal, Multiple              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                         X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |       X           X  X           X              X     X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +|             
      Leukemia Mononuclear                 |       X              X           X              X     X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X     X     X  X     X     X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                         X|             
      Fibroadenoma                         | X     X     X        X     X  X              X  X  X                     |             
      Fibroadenoma, Multiple               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                          X               |             
      Granular Cell Tumor Benign           |                                                             X            |             
      Leukemia Mononuclear                 |       X              X                          X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X  X                                                         |             
      Leukemia Mononuclear                 |       X        X  X  X     X     X     X  X     X     X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X                          X                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X           X              X                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                             +                 +                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X           X  X           X              X                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X              X                                X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X  X  X     X     X     X  X     X     X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  I  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  I  I  A  +  +  +  +  I  I  +  I  +  +  I  +  +  A  +  +|  31        |
      Leiomyosarcoma                       |          X                                                               |          1 |
      Peyer's Patch, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X        X           X  X     X  X     X        X  X  X     X     X      |         22 |
      Neoplastic Nodule                    |                   X                                                     X|          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                    +  +                                                |   4        |
      Fat, Leukemia Mononuclear            |                      X  X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X              X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X                       X                        |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X                          X                     |          3 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X  X              X        X  X              X      |          9 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                        X                 X               |          2 |
      Leukemia Mononuclear                 |                      X  X        X     X        X  X              X      |         14 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  37        |
      Leukemia Mononuclear                 |                         X        X     X        X  X              X      |          8 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |          X                                                           X   |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  40        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Adenoma               | X        X  X  X  X           X     X  X           X  X  X     X        X|         28 |
      Pars Distalis, Carcinoma             |                                              X                           |          2 |
      Pars Distalis, Leukemia Mononuclear  |                                                 X                        |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      C-Cell, Adenoma                      |                                     X        X                           |          4 |
      C-Cell, Carcinoma                    |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                          X               |          4 |
      Duct, Carcinoma                      |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granulosa Cell Tumor Benign          |                                     X                                    |          1 |
      Leukemia Mononuclear                 |                                        X        X  X              X      |          8 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Deciduoma Benign                     |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                                |          3 |
      Polyp Stromal                        |                            X     X                                       |          4 |
      Polyp Stromal, Multiple              |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X  X                          X                     |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pancreatic, Leukemia Mononuclear     |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                      X  X  X     X     X        X  X              X      |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Leukemia Mononuclear                 | X                       X        X              X                 X      |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X        X           X  X  X     X     X     X  X  X  X     X     X      |         23 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  A  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
      Leukemia Mononuclear                 |                         X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         |          X        X                 X           X           X           X|         15 |
      Fibroadenoma, Multiple               | X                                                                        |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                              X                           |          2 |
      Granular Cell Tumor Benign           |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X              X        X  X                     |          7 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Leukemia Mononuclear                 |                      X  X        X     X        X  X  X     X     X      |         19 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X              X        X  X              X      |          8 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                      X  X        X     X        X     X           X      |         11 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |       +                          +                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X  X        X     X        X                        |         10 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                  X              X  X                     |          6 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X        X           X  X  X  X  X     X     X  X  X  X     X     X      |         24 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +     +           +  +  +  +  +  M           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +     +           +  +  +  +  A  A           +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +     +           +  I  +  +  A  A           +  +  A  +     A|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  I     +     +           +  A  +  +  A  A           +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     M     +           +  +  +  +  A  A           +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +           +  +  +  +  A  A           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +           +  +  +  +  A  A           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  I     +     +           +  A  +  +  A  A           +  I  A  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  I     +     I           +  +  +  A  A  A           +  A  A  I     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                      X                                                   |             
      Leukemia Mononuclear                 |       X  X  X  X  X           X              X  X  X     X  X            |             
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |             
          Gland                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                             +            |             
      Fat, Leukemia Mononuclear            |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                     X            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                     X            |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +     +        +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +     +        +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +           +  +  +  +  +  A  +        +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +           +  +  +  +  +  +           +  +  +  +     +|             
      Leukemia Mononuclear                 |       X           X           X                             X            |             
      Sarcoma, Metastatic, Skin            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +     +           +  +  +  M  +  A           +  +  +  +     +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |       X     X     X           X                          X  X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +     +           +  M  +  +  +  A           I  +  I  +     +|             
      Leukemia Mononuclear                 |       X     X     X           X                             X            |             
      Pheochromocytoma Benign              |                                                                          |             
      Bilateral, Pheochromocytoma Malignant|                                        X                                 |             
      Bilateral, Pheochromocytoma Benign   |                               X                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +     +           +  +  +  +  +  A           M  M  I  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X  X        X  X     X           X     X  X        X  X  X  X  X|             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |       X                                                     X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +     +           +  +  +  +  A  A           +  +  A  +     +|             
      C-Cell, Adenoma                      |                                        X                                 |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +     +  +        +  M  +  +  +  M           +  +  +  M     M|             
      Adenoma                              | X     X     X        X              X                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X     X                                         X            |             
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |             
          Gland                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +     +        +  +  +  +  +  +  +           +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Polyp Stromal                        | X  X                       X        X                                X   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |             
           Thyroid Gland                   |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |             X                                                            |             
      Renal, Leukemia Mononuclear          |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                     X            |             
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |             
          Gland                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +     +           +  +  +  M  +  A           +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Leukemia Mononuclear                 |       X           X                                      X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X           X              X  X  X     X  X            |             
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Gland                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     M     +           +  +  +  +  +  M           +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                  X                                       |             
      Adenoma                              |                      X                                                   |             
      Fibroadenoma                         | X        X                 X              X        X                    X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +        +  +  +  +  +  M  +           +  +  +  +     +|             
      Subcutaneous Tissue, Fibrosarcoma    |                               X                                          |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +     +           +  +  +  +  +  +           +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +     +           +  +  +  +  +  +           +  +  +  +     +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                   X                          X           X  X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +     +     +           +  +  +  +  +  A           +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Adrenal Gland |                                                                          |             
      Leukemia Mononuclear                 |       X     X     X           X              X     X     X  X            |             
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |             
          Gland                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Leukemia Mononuclear                 |                                                          X  X            |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +     +  +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                       +        +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
      Carcinoma                            |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +           +  +  +  +  +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X           X           X                          X  X            |             
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |             
          Gland                            |                                        X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Leukemia Mononuclear                 |       X                                                  X  X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X           X              X  X  X     X  X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +        +  +  +  +  +  +  +  +  +           +           +      |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +        +  +  +  +  +  +  +  +  +           +           +      |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +        +  +  +  +  +  +  +  +  A           I           +      |  20        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +        +  +  +  M  +  +  +  +  A           +           +      |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +        +  +  +  +  +  +  +  +  +           +           +      |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +        +  +  +  +  +  +  +  +  +           +           +      |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +        +  +  +  +  I  +  +  +  +           +           +      |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          I        +  I  +  +  +  +  +  +  +           +           +      |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          I        I  +  I  +  +  +  +  +  A           A           A      |  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X  X  X  X     X  X           X  X     X                 X     X     X|         24 |
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                +            |   4        |
      Fat, Leukemia Mononuclear            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +        +  +  +  +  +  +  +  +  A           +           +      |  25        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +        +  +  +  +  M  +  +  +  +           +           +      |  25        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     +  +  +  +  +  +  +  +  +  +           +        +  +     +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     +  +  +  +  +  +  +  +  +  +           +        +  +     +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     +  +  +  +  +  +  +  +  +  +           +        +  +     +|  31        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +        +  +  +  +  +  +  +  +  +           +           +      |  28        |
      Leukemia Mononuclear                 |                   X              X        X                              |          7 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +     +  +  +  +  +  +  +  +  A           +           +      |  26        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +     +  +  +  +  +  +  +  +  A           +           +      |  25        |
      Carcinoma                            |             X                                                            |          1 |
      Leukemia Mononuclear                 |          X        X  X           X  X                                    |         11 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +     +  +  +  I  M  +  +  +  A           +           +      |  21        |
      Leukemia Mononuclear                 |          X        X  X           X                                       |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |                      X           X                                       |          2 |
      Bilateral, Pheochromocytoma Malignant|                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +        M  +  +  +  +  +  +  +  A           +           +      |  24        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     +  +  M  +  +  +  M  +  +  +           +           +      |  22        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +|  44        |
      Pars Distalis, Adenoma               | X           X  X  X                          X  X     X     X     X  X  X|         26 |
      Pars Distalis, Carcinoma             |                         X  X                                   X         |          3 |
      Pars Distalis, Leukemia Mononuclear  | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +     +  +  +  +  +  +  +  +  +  A           +           +  +  +|  26        |
      C-Cell, Adenoma                      |                                                                      X   |          2 |
      C-Cell, Carcinoma                    |                                                                         X|          1 |
      Follicular Cell, Adenoma             |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +        +  +  +  +  +  +  +  +  +           +           +      |  25        |
      Adenoma                              |                               X                                          |          6 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X  X                             X                                      X|          8 |
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +        +  +  +  +  +  +  +  +  +           +        +  +      |  31        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |                   X                                            X         |          7 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +        +  +  +  +  +  +  +  +  +           +           +      |  26        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mediastinal, Carcinoma, Metastatic,  |                                                                          |            |
           Thyroid Gland                   |                                                                         X|          1 |
      Mesenteric, Leukemia Mononuclear     | X                                                                        |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X        X                                                              X|          5 |
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +        +  +  +  +  M  +  +  +  +           +           I      |  25        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                        X                                 |          1 |
      Leukemia Mononuclear                 | X                                   X     X                              |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X  X  X     X  X           X  X     X                       X     X|         23 |
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +        +  +  M  +  +  +  +  M  +           +           +      |  23        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |             X                                                            |          2 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |             X              X                    X           X           X|         11 |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +     +  +  +  +  +  +  +  +  +     +     +     +     +     +|  33        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +        +  +  +  +  +  +  +  +  +           +           +     +|  29        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +        +  +  +  +  +  +  +  +  +           +        +  +      |  28        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                         X  X                                   X         |          3 |
      Leukemia Mononuclear                 |                                  X        X                              |          6 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +        +  +  +  +  +  +  +  +  A           +           +      |  24        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Adrenal Gland |             X                                                            |          1 |
      Leukemia Mononuclear                 | X  X  X  X        X  X           X  X     X                             X|         18 |
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 | X        X                       X                                       |          5 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +        +  +  +  +  +  +  +  +  I           +           +      |  25        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                        +                                 |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +        +  +     +|  37        |
      Leukemia Mononuclear                 | X        X        X              X        X                              |         10 |
      Neoplasm NOS, Metastatic, Adrenal    |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +        +  +  M  +  M  +  +  +  +           +           +      |  24        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X  X  X     X  X           X  X     X                 X     X     X|         24 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|             
                                           | 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +           +  +  +        +     +        +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +           +  +  +        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        A           +  +  A        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        A           +  +  +        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +           +  +  +        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        A           +  +  +        +     A        A                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        A           +  +  +        +     A        A                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        A           M  +  I        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | I        A           +  +  I        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X        X     X  X     X     X     X           X  X           X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +           +  +  +        +     +        +                    A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 | +                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +           M  +  +        +     M        +                    +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +           +  +  +        +     +        +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +           +  +  +        +     +        +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +           +  +  +        +     A        +                    +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +           +  +  +        +     +        +                    +|             
      Leukemia Mononuclear                 |                         X                                               X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +        +  +  +  +        +     +        +        +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +        +  +  +  +        +     +        +        +           +|             
      Adenoma                              |                                                             X            |             
      Leukemia Mononuclear                 |                   X     X                                               X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +        +  +  +  +        I     +        +        +           M|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pheochromocytoma Benign              |                                                             X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +           +  +  +        +     +        +                    A|             
      Adenoma                              |                         X                                                |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +           +  +  +        M     +        +                    +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |          X  X  X  X  X     X  X  X  X  X  X     X  X  X  X  X     X  X  X|             
      Pars Distalis, Carcinoma             | X                                                                        |             
      Pars Distalis, Leukemia Mononuclear  |                   X     X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|             
                                           | 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +           +  +  +        +     +        +                    A|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +           +  +  +        +     +        +              +     +|             
      Adenoma                              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Leukemia Mononuclear                 |                   X     X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +           +  +  +        +     +        +                    +|             
      Polyp Stromal                        |                         X  X                                            X|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +           +  +  +        +     A        +                    +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X                                               X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +           M  +  +        +     M        +                    +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X        X     X        X     X     X           X  X           X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +           +  +  +        +     +        +                    +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                      X                                                   |             
      Fibroadenoma                         |                   X           X        X                 X  X           X|             
                                            __________________________________________________________________________|             
   Skin                                    | +        +        +  +  +  +     +  +  +  +        +     +              +|             
      Basal Cell Adenoma                   |                         X                                                |             
      Basal Cell Carcinoma                 |                                  X                                       |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +           +  +  +        +     +        +                    +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +           +  +  +        +     +        +                    +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|             
                                           | 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Gland                            | X                                                                        |             
      Glioma NOS                           |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        +           +  +  +        +     A        +                    A|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                   X      |             
      Leukemia Mononuclear                 |          X        X     X              X                                X|             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                               X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +           +  +  +        +     A        +                    A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                         +            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                            +     +     +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +        +  +  +  +  +  +     +        +  +     +        +  +|             
      Leukemia Mononuclear                 |                         X                                               X|             
      Renal Tubule, Adenoma                |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +           +  +  +        +     +        +                    +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X        X     X  X     X     X     X           X  X           X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +     +  M  +  +  +  +              +                 +  +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +     +  A  A  +  +  +              +                 +  +   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  A  +     +  M  A  +  A  +              I                 I  +   |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +     +  A  A  +  +  +              +                 +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       M  A  +     +  A  A  +  +  +              +                 +  +   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +  I     +  A  A  +  +  +              +                 +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  I     +  A  A  +  +  +              +                 +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       I  A  I     +  A  A  A  A  A              I                 I  I   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       I  +  I     +  A  A  I  I  +              A                 A  +   |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X     X  X  X                       X     X  X                 X   |         20 |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +     +  A  +  +  +  +              +                 +  +   |  19        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +     +  +  +  +  +  +              +                 +  +   |  19        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +     +  +  +  +  +  +        +     +                 +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +     +  A  +  +  +  +        +     +                 +  +   |  20        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
      Leukemia Mononuclear                 |       X           X                                                  X   |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +     +  A  +  +  +  +              +           +     +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +     +  A  +  +  +  +              +           +     +  +   |  23        |
      Adenoma                              |          X                                                               |          2 |
      Leukemia Mononuclear                 |       X     X     X                             X                    X   |          8 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +     +  A  +  M  +  M              +                 +  +   |  18        |
      Leukemia Mononuclear                 |       X     X     X                             X                    X   |          6 |
      Pheochromocytoma Benign              |                   X           X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +     +  A  +  +  +  +           +  +                 +  +   |  20        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                              X                           |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +     +  +  +  +  +  M              M                 +  +   |  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +     +  +   |  42        |
      Pars Distalis, Adenoma               | X  X     X  X  X                 X  X  X  X     X  X     X        X      |         32 |
      Pars Distalis, Carcinoma             |                            X                                             |          2 |
      Pars Distalis, Leukemia Mononuclear  |             X                                                            |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  A  +     +  A  +  +  +  +              +                 +  +   |  18        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  +  +     +  M  +  +  +  +              +                 +  +   |  21        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Malignant       |                                                          X               |          1 |
      Leukemia Mononuclear                 |             X     X                                                      |          4 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +     +  +  +  +  +  +              +  +              +  +   |  23        |
      Polyp Stromal                        | X                       X                                                |          5 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +     +  A  +  +  +  +              +                 +  +   |  19        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |       X     X     X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +  +     +  +  +  M  +  +              +     +           +  +   |  19        |
      Leukemia Mononuclear                 |       X     X     X                                                      |          4 |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X     X     X  X  X                 X     X     X  X                 X   |         20 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +  +     +  M  +  +  +  +              +                 +  +   |  20        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         |    X              X                    X     X        X        X     X   |         13 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +  +  +     +     +  +     +        +  +  +   |  30        |
      Basal Cell Adenoma                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                              X                           |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                            X                                             |          2 |
      Glioma NOS                           |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +  +  +     +  A  +  +  +  +              +                 +  +   |  18        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                X                                                         |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |          2 |
      Leukemia Mononuclear                 | X     X     X     X                             X                    X   |         11 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                   X                             X                        |          4 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +     +  A  +  +  +  +              +                 +  +   |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |          +              +                                   +        +   |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  A  +  +  +  +     +        +        +     +  +  +   |  30        |
      Leukemia Mononuclear                 |       X     X     X                             X                    X   |          7 |
      Renal Tubule, Adenoma                |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  M  +     +  +  +  +  +  +              +                 +  +   |  20        |
      Leukemia Mononuclear                 |       X           X                                                      |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X     X  X  X                 X     X     X  X                 X   |         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                       X                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  I  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X     X  X  X     X  X  X  X  X        X  X     X  X  X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X  X                    X        X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  I|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Pheochromocytoma Benign              |    X        X                                         X        X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X     X  X     X     X  X  X     X  X  X  X     X  X  X  X  X         |             
      Pars Distalis, Carcinoma             |                      X                                            X     X|             
      Pars Distalis, Leukemia Mononuclear  |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Carcinoma           |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                X     X                        |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                        X                                 |             
      Leukemia Mononuclear                 | X                                X                             X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Polyp Stromal                        |                      X     X                       X              X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                  X                                       |             
      Mesenteric, Leukemia Mononuclear     |                                  X                                       |             
      Renal, Leukemia Mononuclear          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +|             
      Leukemia Mononuclear                 |             X                    X                             X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                X                             X  X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 | X           X     X  X  X     X  X  X  X  X     X  X  X     X  X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         | X  X           X     X        X  X  X                 X              X  X|             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Leukemia        |                                                                          |             
          Mononuclear                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                      X                                            X     X|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X           X        X  X  X  X           X        X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +                          +                       +                 +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
      Carcinoma                            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 | X           X     X  X  X     X  X  X  X  X     X  X  X     X  X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +|  46        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A|  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  M  +  +  +  +  +|  43        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  I  +  +  +  A  +  +  I  +  +  A  A  +  +  A  +  +  +  +  +  A  A|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A|  38        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X        X  X  X  X  X  X  X  X     X        X  X               |         29 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X        X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                        X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X        X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X                    X  X     X                                 |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Leukemia Mononuclear                 |       X  X                    X  X                                       |          9 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  I  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  44        |
      Leukemia Mononuclear                 |                               X                                          |          2 |
      Pheochromocytoma Benign              |    X                       X                                             |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  I|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Pars Distalis, Adenoma               | X  X        X  X        X  X     X  X     X  X  X  X  X  X     X         |         32 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Carcinoma             |                                                                          |          3 |
      Pars Distalis, Leukemia Mononuclear  |                               X        X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, C-Cell, Adenoma           |                                                                   X      |          1 |
      C-Cell, Adenoma                      |                                                 X                        |          2 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                   X      |          4 |
      Leukemia Mononuclear                 |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Leukemia Mononuclear                 |          X                    X        X                                 |          6 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp Stromal                        |       X                    X     X                 X                     |          8 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |                               X                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Leukemia Mononuclear                 |    X  X  X                    X  X     X                                 |          9 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |       X  X        X           X        X                                 |          9 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Monocytic                   |                         X                                                |          1 |
      Leukemia Mononuclear                 |    X  X  X  X     X  X     X  X  X  X  X     X        X  X  X        X   |         32 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                               X        X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroadenoma                         |       X           X                       X                          X   |         14 |
      Fibroadenoma, Multiple               |                         X           X                          X         |          3 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      | X                                                                        |          1 |
      Subcutaneous Tissue, Leukemia        |                                                                          |            |
          Mononuclear                      |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          3 |
      Leukemia Mononuclear                 |                               X        X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X  X        X  X        X  X  X  X                                 |         17 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |       X                       X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                   +        +                             +               |   7        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   2        |
      Carcinoma                            |                                                                         X|          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                          X        X                                 |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                               X        X                                 |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Monocytic                   |                         X                                                |          1 |
      Leukemia Mononuclear                 |    X  X  X  X     X  X  X  X  X  X  X  X     X        X  X  X        X   |         33 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  I  +  +  +  +  +  I  +  +  +  +  +  +  I  +  +  A  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  A  +  A  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                         X|             
      Leukemia Mononuclear                 | X           X     X  X  X           X  X  X  X              X  X  X      |             
      Neoplastic Nodule                    |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                                            +      |             
      Fat, Leukemia Mononuclear            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X           X     X                 X            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X           X  X                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                               +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X              X  X                 X  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Leukemia Mononuclear                 |             X     X                    X     X              X  X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |             X     X                    X     X              X  X  X      |             
      Pheochromocytoma Malignant           |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Complex             |                                                    X                     |             
      Pheochromocytoma Benign              |          X  X     X  X     X     X                    X     X  X  X  X   |             
      Bilateral, Pheochromocytoma Malignant|                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                                     X                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Adenoma                              |                                                       X              X   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pars Distalis, Adenoma               |    X     X  X     X        X              X        X  X  X     X  X     X|             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |             X     X     X              X                    X  X  X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Lipoma                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +                                      +  +  +     +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X  X        X     X     X  X  X  X        X  X        X           X   |             
      Bilateral, Tunic, Mesothelioma       |                                                                          |             
          Malignant                        |       X                                                                  |             
      Interstitial Cell, Adenoma           | X           X     X                       X           X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X     X           X  X     X              X  X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                     X                                    |             
      Mesenteric, Leukemia Mononuclear     | X                 X     X           X  X                    X  X         |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
      Renal, Leukemia Mononuclear          |                                     X                       X     X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X     X     X           X  X  X                 X  X  X      |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                 X     X           X  X  X                 X  X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X  X     X        X  X  X  X  X              X  X  X      |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                   X                                         X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  +  M  +  +  M  +  +  M  +  M  M  M  M  +  +  +  M  +  +  M  +|             
      Fibroadenoma                         |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |          X                                                               |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma NOS                      |                                                       X                  |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                   X     X           X  X                          X      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X           X                                                   |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Leukemia Mononuclear                 | X           X     X     X              X  X  X              X  X         |             
      Lymphoma Malignant                   |                                     X                                    |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X           X  X  X                    X  X      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X  X  X           X  X  X                 X  X         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                   +           +     +  +     +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                             +|             
      Carcinoma                            |                                           X                             X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X     X           X  X                    X  X         |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X  X  X  X        X  X  X  X  X              X  X  X      |             
      Lymphoma Malignant                   |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |                      X                                                   |             
      Mesothelioma Malignant               |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  44        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  A  +  +  +  +|  42        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  A  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                              X                           |          2 |
      Leukemia Mononuclear                 |    X  X        X  X  X        X           X  X     X  X     X     X  X  X|         26 |
      Neoplastic Nodule                    |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +     +            |   5        |
      Fat, Leukemia Mononuclear            |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          5 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                          +               |   1        |
      Palate, Adenoma                      |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                    X|          5 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X           X  X     X        X           X|         13 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                X              X           X  X     X  X     X           X|         14 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  M  +  +  +  +  +  M  +  M  M|  42        |
      Leukemia Mononuclear                 |                               X                    X  X     X            |         11 |
      Pheochromocytoma Malignant           |                                                          X        X      |          3 |
      Pheochromocytoma Complex             |                                                                          |          1 |
      Pheochromocytoma Benign              |    X     X     X                                         X        X      |         16 |
      Bilateral, Pheochromocytoma Malignant|                   X                                                      |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  I|  42        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X  X        X  X              X  X  X           X  X  X  X     X        X|         25 |
      Pars Distalis, Carcinoma             |                                           X                              |          1 |
      Pars Distalis, Leukemia Mononuclear  |                               X           X  X     X                    X|         12 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      C-Cell, Adenoma                      |       X                                                  X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
      Lipoma                               |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                     X  X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                       +     +            |   7        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                    X                    X|          2 |
      Bilateral, Interstitial Cell, Adenoma|       X  X  X     X  X     X           X                 X        X  X   |         22 |
      Bilateral, Tunic, Mesothelioma       |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Interstitial Cell, Adenoma           |    X                          X  X           X                           |          9 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X              X     X                    X|         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |                                                                         X|          8 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X              X     X  X     X           X|         16 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Leukemia Mononuclear                 |    X                          X              X                          X|         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X        X  X  X        X           X  X     X  X  X  X     X  X  X|         28 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +|  39        |
      Leukemia Mononuclear                 |                                                    X                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  +  +  M  +  M  M  +  M  M  M  M  M  M  +  M  M  +  +  M|  21        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Trichoepithelioma                    |                                                                      X   |          1 |
      Subcutaneous Tissue, Fibroma         |                      X                                                   |          1 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma NOS                      |                                                                          |          1 |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                           X                              |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                              X     X                     |          7 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |          X                             X                                 |          4 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                              X                           |          1 |
      Leukemia Mononuclear                 |    X  X           X  X        X           X  X     X  X     X        X  X|         21 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Squamous Cell Carcinoma              |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                               X              X     X                    X|         12 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                               X              X     X        X           X|         14 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                         +|   7        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X           X  X  X        X           X  X     X  X  X  X        X  X|         20 |
      Renal Tubule, Adenoma                |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                               X              X                          X|          4 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X        X  X  X        X           X  X     X  X  X  X     X  X  X|         29 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +  A     +        A  +        +  +  +     +           +  A  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M     +  +     +        +  +        +  +  +     +           +  A  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     I  +     +        +  +        +  I  +     +           +  A  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +  A     +        A  +        A  +  +     +           +  A  +  +  I|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A     +  A     +        A  +        A  +  +     +           +  A  +  A  I|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |             X                                                            |             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X           X  X     X  X  X  X     X        X  X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                     X            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X                                                  X            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +     +  +        +  +  +     +           +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X     X        X              X        X           X        X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X     X     X  X                       X  X  X     X        X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X     X     X  X                             X              X   |             
      Pheochromocytoma Benign              |    X              X        X     X              X                        |             
      Bilateral, Pheochromocytoma Benign   |          X           X                    X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +        +  +        +  +  +  +  +     +  +  +  +  +  +  +|             
      Adenoma                              |                                     X        X  X     X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +     +        +  +        +  +  +     +           +  +  +  +  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X        X  X     X  X     X     X     X  X  X           X     X|             
      Pars Distalis, Carcinoma             |                                        X                       X         |             
      Pars Distalis, Leukemia Mononuclear  | X     X  X                                   X  X  X        X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |                            X     X        X                 X           X|             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +                                                     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|             X        X  X     X  X  X        X  X        X  X  X     X  X|             
      Interstitial Cell, Adenoma           | X  X     X                 X              X                       X      |             
      Tunic, Mesothelioma Benign           |                      X                                                   |             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X        X                                X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +        +  +        +  +  +     +  +        +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                    X                     |             
      Mesenteric, Leukemia Mononuclear     |                                                    X                     |             
      Renal, Leukemia Mononuclear          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +  +     +        +  +        +  +  I     +           +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 | X     X  X     X        X                       X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  I     M        +  +        M  +  +     +           +  +  M  +  M|             
      Leukemia Mononuclear                 | X     X                 X                       X           X        X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Leukemia Mononuclear                 | X     X  X     X  X  X  X              X     X  X  X  X     X        X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | I     +  +     +        M  +        +  +  +     +           +  +  M  +  +|             
      Leukemia Mononuclear                 |       X                                                     X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M     M        +  M        M  +  +     M           M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Keratoacanthoma                      |          X                                                               |             
      Subcutaneous Tissue, Fibroma         |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                X         |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 | X        X     X                                X           X        X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | A     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |             X                       X                                    |             
      Leukemia Mononuclear                 | X     X  X     X     X  X              X        X  X  X     X        X   |             
      Squamous Cell Carcinoma              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X        X     X        X                       X           X        X   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                 +              +                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +     +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X  X     X     X  X              X        X     X     X        X   |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
      Leukemia Mononuclear                 | X     X                                         X           X            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X  X           X  X     X  X  X  X     X        X  X|             
      Mesothelioma Benign                  |                      X                                                   |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +     +        +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  M  +  +  +  +     I     +  +     +  +  +  I     +        +|  26        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  M  +  +     +     +  +     +  +  +  +     +        +|  32        |
      Leukemia Mononuclear                 |                   X              X                                      X|          3 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +     +        +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     I     +  +     +  +  +  +     +        +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     I     +  +     +  +  +  +     +        +|  30        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  A  A  M  I  +  +  +     I     +  +     +  +  +  +     +        +|  22        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  M  +  A  A  +  +  +     I     +  A     +  +  +  A     A        A|  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Adenoma               |                            X                                             |          2 |
      Leukemia Mononuclear                 | X  X  X     X     X  X  X     X  X  X  X  X              X  X  X  X  X  X|         35 |
      Neoplastic Nodule                    |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                            +                           |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Leukemia Mononuclear                 |    X                    X        X                       X              X|          7 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Leukemia Mononuclear                 |    X              X              X                                      X|          7 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Leukemia Mononuclear                 |                         X                                               X|          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  32        |
      Leukemia Mononuclear                 |                   X              X                                      X|          4 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +  +  +        +|  35        |
      Leukemia Mononuclear                 | X  X              X              X     X                 X     X        X|         17 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X     X     X     X        X  X  X                 X     X        X|         23 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X        X     X     X        X     X                 X     X        X|         17 |
      Pheochromocytoma Benign              |                   X  X        X              X           X     X  X      |         12 |
      Bilateral, Pheochromocytoma Benign   |                         X              X                                 |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  36        |
      Adenoma                              |                   X                                                      |          5 |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +     +        +|  32        |
      Adenoma                              |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +     +     +  +|  43        |
      Pars Distalis, Adenoma               |                         X  X  X  X  X  X        X  X  X        X     X   |         25 |
      Pars Distalis, Carcinoma             |             X                                                            |          3 |
      Pars Distalis, Leukemia Mononuclear  |    X        X     X              X     X                 X              X|         14 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, C-Cell, Adenoma           |                                                             X            |          1 |
      C-Cell, Adenoma                      |                                        X           X     X               |          8 |
      C-Cell, Carcinoma                    |                            X                                             |          1 |
      Follicular Cell, Adenoma             |                                                             X            |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +     +  +     +     +  +     +  +  M  +     +        +|  32        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Adenoma                              |                      X                                               X   |          2 |
      Carcinoma                            |                                           X                              |          1 |
      Leukemia Mononuclear                 |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  34        |
      Leukemia Mononuclear                 |    X                             X                                      X|          3 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                      +   |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 | X                 X                                                     X|          3 |
      Bilateral, Interstitial Cell, Adenoma| X        X        X        X  X  X     X  X  X     X     X  X     X      |         26 |
      Interstitial Cell, Adenoma           |       X     X           X           X                          X     X   |         12 |
      Tunic, Mesothelioma Benign           |                                                                          |          1 |
      Tunic, Mesothelioma Malignant        |                                                    X                    X|          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Leukemia Mononuclear                 | X  X              X                    X                 X              X|         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +     +  +     +     +  +  +  +  +  +  +     +        +|  35        |
      Axillary, Leukemia Mononuclear       |    X                                                                     |          1 |
      Deep Cervical, Leukemia Mononuclear  |    X                                                                     |          1 |
      Iliac, Leukemia Mononuclear          |    X                                                                     |          1 |
      Mediastinal, Leukemia Mononuclear    | X  X              X                                                     X|          5 |
      Mesenteric, Leukemia Mononuclear     | X  X              X              X                       X              X|          7 |
      Renal, Leukemia Mononuclear          |    X              X                                                     X|          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  M  +  M  +     +  +     +     +  +     +  +  +  +     +        +|  29        |
      Carcinoma, Metastatic, Thyroid Gland |                            X                                             |          1 |
      Leukemia Mononuclear                 |    X  X           X     X              X                 X     X        X|         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +     +     +  +     +  M  +  +     +        +|  27        |
      Leukemia Mononuclear                 |    X  X           X              X                       X              X|         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X  X  X     X     X  X  X     X  X  X  X  X              X  X  X  X  X  X|         33 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  M  +     +  +     +     +  +     +  +  +  +     +        M|  26        |
      Leukemia Mononuclear                 |    X              X              X     X                 X               |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M     M  +     +     M        M  +  +  +     M        +|  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +     +  +     +     +  +     +  +  +  +     +        +|  32        |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Astrocytoma NOS                      |          X                                                               |          1 |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |             X                                                            |          2 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                       X                  |          1 |
      Leukemia Mononuclear                 | X  X              X     X        X                                      X|         12 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | A  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  30        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                   X                 X                                    |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Leukemia Mononuclear                 | X  X  X           X     X     X  X  X  X                 X  X  X  X     X|         26 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X              X  X           X     X                 X              X|         15 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | A  +  +  +  +  +  +     I  +     +     +  +     +  +  +  +     +        I|  29        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                   +              +   |   6        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
      Carcinoma                            |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +|  44        |
      Leukemia Mononuclear                 | X  X  X           X     X        X  X  X                 X     X        X|         22 |
      Renal Tubule, Adenoma                |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +     I     +  +     +  +  +  +     +        +|  31        |
      Leukemia Mononuclear                 |    X                                                     X              X|          7 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X  X     X     X  X  X     X  X  X  X  X              X  X  X  X  X  X|         35 |
      Mesothelioma Benign                  |                                                                          |          1 |
      Mesothelioma Malignant               |                                                    X                    X|          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +        +        +           +     +     +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +        A        +           +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | I  +  +     +  +  +        M        +           +     I     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +        A        +           +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +        A        +           +     +     +  +  +  A  I|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +        +        +           +     +     I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A     +  +  +        A        +           +     I     +  +  +  A  I|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  A     A  +  +        A        I           +     I     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X  X        X  X  X  X  X  X  X  X  X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +        M        +           A     +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X           X      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Adenoma                      |                                                                          |             
      Palate, Papilloma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                X           X        X           X                 X  X  X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 | X  X     X  X  X           X  X  X  X  X                          X  X  X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X           X  X     X  X                          X  X  X|             
      Pheochromocytoma Malignant           |                                        X     X                           |             
      Pheochromocytoma Benign              |                         X           X  X           X     X           X   |             
      Bilateral, Pheochromocytoma Benign   |                                                                   X     X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +        M     +  +           A     +     +  +  +  +  +|             
      Adenoma                              |                                  X                                   X   |             
      Carcinoma                            |       X                                               X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +        +     +  +     +  +  A     +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X        X        X     X        X  X              X  X  X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Carcinoma             |                                                          X               |             
      Pars Distalis, Leukemia Mononuclear  |                X                                                  X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +     +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                                                      |             
      C-Cell, Carcinoma                    |    X                                                                     |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +        +        +           +     +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Adenoma                              |          X                                                               |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Bilateral, Interstitial Cell, Adenoma|    X     X           X  X     X  X     X     X     X  X           X  X  X|             
      Interstitial Cell, Adenoma           |       X                             X     X     X        X               |             
      Tunic, Mesothelioma Malignant        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X                    X                 X           X     X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +        +  +     +  +        +     +     +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                X                                                         |             
      Deep Cervical, Leukemia Mononuclear  |                X                                                         |             
      Iliac, Leukemia Mononuclear          |                X                                                         |             
      Mediastinal, Leukemia Mononuclear    |                                        X                                X|             
      Mesenteric, Leukemia Mononuclear     |                X                       X                                X|             
      Renal, Leukemia Mononuclear          |                X              X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Leukemia Mononuclear                 |    X        X  X           X        X                 X           X  X  X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                      X           X  X  X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X  X        X  X  X  X  X  X  X  X  X  X  X           X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     M  +  +        +        +           A     M     +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                        X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +     M  +  +        +        +           M     M     M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +        +        +     +     +     +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                X                          X              X               |             
      Squamous Cell Papilloma              |                                           X                              |             
      Sebaceous Gland, Adenoma             |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 | X                          X        X           X                 X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +  +        A        +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                         X|             
      Leukemia Mononuclear                 | X  X     X  X  X        X  X  X  X  X  X  X     X     X           X  X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X           X  X     X  X                          X      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +     +  +        A     +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X           X        X  X                          X     X|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                     X           X  X   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X     X  X  X        X  X  X  X  X  X  X  X  X  X  X           X  X  X|             
      Mesothelioma Malignant               |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +     +  +     +  +     +           +  +     +  +  +     +|  28        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A        A  +     +  +     A  +     +           +  +     A  +  +     +|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A        A  +     +  +     A  +     +           +  +     A  +  +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A        A  +     +  +     A  +     +           +  +     A  +  +     +|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A        M  +     +  +     A  +     +           M  M     M  +  +     +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A        A  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A        A  +     +  +     +  +     M           I  +     +  +  +     I|  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A        A  +     +  +     A  +     A           I  I     +  +  +     +|  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A        A  +     I  +     A  A     +           +  I     A  +  I     I|  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X        X  X  X  X  X              X  X  X                 X|         28 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                      +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  26        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                +                                               +         |   2        |
      Palate, Adenoma                      |                X                                                         |          1 |
      Palate, Papilloma                    |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    A        +  +     +  +     +  +     +           +  +     +  +  +  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    A        +  +     +  +     +  +     +           +  +     +  +  +  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    A        +  +     +  +     +  +     +           +  +     +  +  +  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +     +  +     +  +     +  +        +  +     +  +  +     +|  30        |
      Leukemia Mononuclear                 |                      X                                X                  |          9 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                              X                           |          1 |
      Leukemia Mononuclear                 |             X        X  X  X     X                 X  X                 X|         21 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |             X        X  X        X                 X  X                 X|         17 |
      Pheochromocytoma Malignant           |    X                                                        X            |          4 |
      Pheochromocytoma Benign              |                         X                    X           X     X         |         10 |
      Bilateral, Pheochromocytoma Benign   |                                                    X                     |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +        +  +     +  M     +  +     +           +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +     +     +     +  +  +  +  +  +  +  +|  40        |
      Pars Distalis, Adenoma               | X  X  X     X     X     X              X     X        X  X  X  X     X   |         25 |
      Pars Distalis, Carcinoma             |                            X                                             |          2 |
      Pars Distalis, Leukemia Mononuclear  |                            X                       X                     |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Adenoma                      |          X  X              X                       X           X        X|          7 |
      C-Cell, Carcinoma                    |                                                             X            |          2 |
      Follicular Cell, Adenoma             |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    M        +  +     I  +     +  +     +           +  +     +  +  +     +|  26        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                             +            |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  A  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Adenoma                              |                                              X                           |          2 |
      Carcinoma                            |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                               +        +     +              +            |   6        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X     X  X     X                    X     X     X  X  X  X  X     X  X   |         26 |
      Interstitial Cell, Adenoma           |                   X     X        X           X                          X|         10 |
      Tunic, Mesothelioma Malignant        |          X                             X                                 |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    A        A  +     +  +     +  +     +           +  +     +  +  +     +|  26        |
      Leukemia Mononuclear                 |                      X           X                    X                  |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  A        +  +     +  +     +  +     +           +  +     +  +  +     +|  30        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    M        +  M     +  +     +  +     +           +  +     +  +  +     +|  25        |
      Leukemia Mononuclear                 |                      X  X        X                 X  X                  |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  28        |
      Leukemia Mononuclear                 |             X        X  X        X                 X  X                 X|         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |       X     X        X  X  X  X  X              X  X  X                 X|         30 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M        +  +     +  +     +  +     +           +  +     +  +  +     +|  25        |
      Leukemia Mononuclear                 |                                  X                                       |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M        +  M     M  M     M  M     +           M  +     +  M  M     +|  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  30        |
      Keratoacanthoma                      |                                                                          |          3 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +     +  +     +  +     +           +  +     +  +  +     +|  29        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +     +  +  +  +  +     +           +  +     +  +  +     +|  30        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                            X                                             |          1 |
      Leukemia Mononuclear                 |                                                       X                  |          6 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    A        +  +     +  +     +  +     +           +  +     A  +  +     +|  25        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X  X  X     X              X  X  X                 X|         26 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X                             X                  |          9 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    A        +  +     +  +     +  +     +           +  +     A  +  +     +|  26        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +           +         |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +  +|  39        |
      Leukemia Mononuclear                 |                      X  X        X                    X                 X|         13 |
      Renal Tubule, Adenoma                |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
      Leukemia Mononuclear                 |                         X                                                |          5 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X     X        X  X  X  X  X              X  X  X                 X|         30 |
      Mesothelioma Malignant               |          X                             X                                 |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X        X  X  X  X     X     X                 X     X   |             
      Neoplastic Nodule                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |    +                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X        X                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X        X              X     X                 X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Leukemia Mononuclear                 | X              X           X  X              X  X                    X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  I  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M  +  +|             
      Leukemia Mononuclear                 | X                                            X                       X   |             
      Pheochromocytoma Malignant           |                                                       X                  |             
      Pheochromocytoma Benign              | X                 X  X                 X        X  X           X     X   |             
      Bilateral, Pheochromocytoma Benign   |                            X                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                   X                       X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Adenoma               |    X  X  X  X     X     X     X  X        X     X  X  X  X  X           X|             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                X                             X                       X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |       X                                               X              X   |             
      Follicular Cell, Adenoma             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  +  M|             
                                            __________________________________________________________________________|             
   Penis                                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                       X              X   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X           X  X  X  X  X  X     X     X  X           X     X     X   |             
      Interstitial Cell, Adenoma           |          X                       X     X           X        X     X      |             
      Tunic, Mesothelioma Malignant        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X              X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Leukemia Mononuclear          |                X                                                         |             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
      Mesenteric, Leukemia Mononuclear     |                X                                                         |             
      Pancreatic, Leukemia Mononuclear     |                X              X                                          |             
      Renal, Leukemia Mononuclear          |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                X              X              X                 X         |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X                 X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X        X  X  X  X     X  X  X                 X     X   |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  +  A  M  M  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  M  +  +  M  +  M  +  +  M  M  M  +  +  +  +  +  M  +  M  +  M|             
      Fibroadenoma                         |                               X                                          |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                       X                  |             
      Subcutaneous Tissue, Fibroma         |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
      Oligodendroglioma Malignant          |                                                                          |             
      Meninges, Carcinoma, Metastatic,     |                                                                          |             
           Zymbal's Gland                  |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Carcinoma, Metastatic, Zymbal's Gland|                                                             X            |             
      Leukemia Mononuclear                 | X              X           X           X     X  X              X     X   |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
      Pheochromocytoma Malignant,          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Submucosa, Adenocarcinoma            |                                                                          |             
      Vomeronasal Organ, Squamous Cell     |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
      Carcinoma                            |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X        X  X                 X  X              X     X   |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X        X  X  X  X     X  X  X  X              X     X   |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  I  +  +  +  +  +|  43        |
      Leukemia Mononuclear                 |             X                                                        X   |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  +  +  +  A  A  +  +  M  +  +  +  +  +  +  +  +  +|  39        |
      Leukemia Mononuclear                 |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X     X  X  X  X  X  X     X     X           X  X  X           X   |         25 |
      Neoplastic Nodule                    |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +              +        +                           |   4        |
      Carcinoma, Metastatic, Kidney        |                                     X                                    |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma, Metastatic, Kidney        |                                     X                                    |          1 |
      Leukemia Mononuclear                 |    X                                                                 X   |          3 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                     +  +              +                  |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                      X   |          3 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X        X                    X     X              X  X           X   |         14 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X                          X     X           X     X           X   |         14 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +|  38        |
      Leukemia Mononuclear                 |       X           X              X                       X               |          7 |
      Pheochromocytoma Malignant           |                               X                             X            |          3 |
      Pheochromocytoma Benign              |          X                    X           X  X                           |         12 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Pars Distalis, Adenoma               | X     X           X  X  X           X        X     X           X        X|         25 |
      Pars Distalis, Carcinoma             |                            X                          X                  |          2 |
      Pars Distalis, Leukemia Mononuclear  |       X                          X                                   X   |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Adenoma                      |                                              X           X     X         |          6 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  M  +  +  +  +  +  +  +  I  +  +  +  +  +  M  M  +  +  +  +  +  I  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                X         |          3 |
      Carcinoma                            |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +     +                 +     +                              |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X  X     X  X  X  X  X  X  X     X              X  X  X      |         30 |
      Interstitial Cell, Adenoma           | X                                         X     X  X     X               |         11 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                X                                                     X   |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |             X                                                        X   |          3 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Carcinoma, Metastatic, Kidney        |                                     X                                    |          1 |
      Leukemia Mononuclear                 |    X        X  X  X                                      X           X   |         10 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Leukemia Mononuclear                 |    X  X     X        X           X                    X              X   |         10 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X     X  X  X  X  X  X     X     X              X  X     X     X   |         26 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  M  +|  39        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  M  M  M  M  M  +  M  +  +  M  +  +  M  +  M  +  I  +  M  +|  24        |
      Fibroadenoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      | X                                                              X         |          3 |
      Subcutaneous Tissue, Fibroma         |                                  X                 X                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   1        |
      Carcinoma, Metastatic, Kidney        |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Gland                            |                            X                                             |          1 |
      Leukemia Mononuclear                 |    X           X                 X                       X           X   |          6 |
      Oligodendroglioma Malignant          |          X                                                               |          1 |
      Meninges, Carcinoma, Metastatic,     |                                                                          |            |
           Zymbal's Gland                  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Kidney        |                                     X                                    |          1 |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X     X  X  X  X  X  X     X     X              X  X           X   |         21 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                             X                                   X   |          4 |
      Submucosa, Adenocarcinoma            |                      X                                                   |          1 |
      Vomeronasal Organ, Squamous Cell     |                                                                          |            |
          Carcinoma                        |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                X                       X                             X   |          5 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   1        |
      Adenocarcinoma                       |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X  X        X           X     X                       X           X   |         15 |
      Renal Tubule, Carcinoma              |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X                                                                 X   |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05096-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:10:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X  X     X  X  X  X  X  X     X     X           X  X  X     X     X   |         28 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
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