TDMS Study 05096-01 Pathology Tables
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
Facility: Battelle Northwest
Chemical CAS #: 2698-41-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + + + A I + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Small | + A I + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A I + + + + + + + + + + + + + + + I I + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A I A + + + + + I A + A A + + I + I + A + + + +|
Leiomyosarcoma | |
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + A I A + + + + + A A I + A + + I + I I + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + I M + M + M + M + M + I + I + + I + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + I + + + + M + M + + + + + + + + + + M|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Adenoma | X X X |
Duct, Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | X |
Leukemia Mononuclear | X X |
Polyp Stromal | X X |
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + I + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + M M + M +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + M + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X|
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Granular Cell Tumor Benign | X |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + + + A + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + I A A + + + + + + + + + + + + + A + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + I + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + I + + + + + + + + + + + + + + + I +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + I I A + + + + I I + I + + I + + A + +| 31 |
Leiomyosarcoma | X | 1 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + A + I + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X | 22 |
Neoplastic Nodule | X X| 3 |
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + I + + + + + + +| 48 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X | 2 |
Leukemia Mononuclear | X X X X X X X | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + M + + + + + + M + + + + M + + + + +| 37 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + M + + + + M + + + + + + + + + + + M +| 40 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X| 28 |
Pars Distalis, Carcinoma | X | 2 |
Pars Distalis, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + I +| 48 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X | 4 |
C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X | 4 |
Duct, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granulosa Cell Tumor Benign | X | 1 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Deciduoma Benign | | 1 |
Leukemia Mononuclear | X | 3 |
Polyp Stromal | X X | 4 |
Polyp Stromal, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pancreatic, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X X X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 23 |
__________________________________________________________________________|____________|
Thymus | + A + + + + M M + + + + + + + + + + + + + + + + M| 44 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + A + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X X X| 15 |
Fibroadenoma, Multiple | X | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 2 |
Granular Cell Tumor Benign | | 1 |
Leukemia Mononuclear | X X X X | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | | 2 |
Leukemia Mononuclear | X X X X X X X X X | 19 |
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 8 |
__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X | 11 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A A + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + I + + A A + + A + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + I + + + A + + A A + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + A A + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + I + + + A + + A A + I A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + I + I + + + A A A + A A I +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
Neoplasm NOS, Metastatic, Adrenal | |
Gland | X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + M + A + + + + +|
Carcinoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + A I + I + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Malignant| X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + A M M I + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A A + + A + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + M + + + M M|
Adenoma | X X X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Neoplasm NOS, Metastatic, Adrenal | |
Gland | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + A + + + + + + + + +|
Mediastinal, Carcinoma, Metastatic, | |
Thyroid Gland | |
Mesenteric, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X |
Neoplasm NOS, Metastatic, Adrenal | |
Gland | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + A + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Neoplasm NOS, Metastatic, Adrenal | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Gland | X |
__________________________________________________________________________|
Thymus | + + M + + + + + + M + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | X |
Fibroadenoma | X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + A + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Adrenal Gland | |
Leukemia Mononuclear | X X X X X X X X |
Neoplasm NOS, Metastatic, Adrenal | |
Gland | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X |
Neoplasm NOS, Metastatic, Adrenal | |
Gland | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A I + | 20 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + A + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + I + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | I + I + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | I I + I + + + + + A A A | 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 24 |
Neoplasm NOS, Metastatic, Adrenal | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + | 25 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + + + + + + | 25 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + +| 31 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 28 |
Leukemia Mononuclear | X X X | 7 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + A + + | 26 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + | 25 |
Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + I M + + + A + + | 21 |
Leukemia Mononuclear | X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X X | 2 |
Bilateral, Pheochromocytoma Malignant| | 1 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + A + + | 24 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + + + + + | 22 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Adenoma | X X X X X X X X X X X| 26 |
Pars Distalis, Carcinoma | X X X | 3 |
Pars Distalis, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + +| 26 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | X| 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 25 |
Adenoma | X | 6 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X| 8 |
Neoplasm NOS, Metastatic, Adrenal | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 31 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X X | 7 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 26 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Mediastinal, Carcinoma, Metastatic, | | |
Thyroid Gland | X| 1 |
Mesenteric, Leukemia Mononuclear | X | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X| 5 |
Neoplasm NOS, Metastatic, Adrenal | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + I | 25 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 23 |
Neoplasm NOS, Metastatic, Adrenal | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + | 23 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X | 2 |
Adenoma | | 1 |
Fibroadenoma | X X X X X| 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + +| 33 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 29 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 28 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X X X | 3 |
Leukemia Mononuclear | X X | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + | 24 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Adrenal Gland | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X| 18 |
Neoplasm NOS, Metastatic, Adrenal | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Gland | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + I + + | 25 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + +| 37 |
Leukemia Mononuclear | X X X X X | 10 |
Neoplasm NOS, Metastatic, Adrenal | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + M + + + + + + | 24 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|
| 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + A A A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + A A A|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + A A A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A A A|
__________________________________________________________________________|
Intestine Small | + A + + + + A A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A M + I + A A A|
__________________________________________________________________________|
Intestine Small, Jejunum | I A + + I + A A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + M + + + M + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + I + + + M|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|
| 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + +|
Polyp Stromal | X X X|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + + + M + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + M + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Basal Cell Carcinoma | X |
Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|
| 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Gland | X |
Glioma NOS | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + A + A|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X|
Mediastinum, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Trachea | + + + + + + A + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Lacrimal Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A A + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + M A + A + I I + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A A + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M A + + A A + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + + I + A A + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + I + A A + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | I A I + A A A A A I I I | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | I + I + A A I I + A A + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X | 20 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + | 19 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 19 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 21 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + | 20 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 21 |
Leukemia Mononuclear | X X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + | 23 |
Adenoma | X | 2 |
Leukemia Mononuclear | X X X X X | 8 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + A + M + M + + + | 18 |
Leukemia Mononuclear | X X X X X | 6 |
Pheochromocytoma Benign | X X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + | 20 |
Adenoma | | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M + + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + A + + + + + + + + + + + + + + | 42 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X | 32 |
Pars Distalis, Carcinoma | X | 2 |
Pars Distalis, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + A + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + | 21 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Malignant | X | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 23 |
Polyp Stromal | X X | 5 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + | 19 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + | 19 |
Leukemia Mononuclear | X X X | 4 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + | 20 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X X X X | 13 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 30 |
Basal Cell Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Basal Cell Carcinoma | | 1 |
Keratoacanthoma | X | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 21 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 21 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 2 |
Glioma NOS | X | 1 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + A + + + + + + + | 18 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Leukemia Mononuclear | X X X X X X | 11 |
Mediastinum, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + A + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + | 30 |
Leukemia Mononuclear | X X X X X | 7 |
Renal Tubule, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + + + + + | 20 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | M M + M M + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + I + + + + + + + I + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + I + + + + A + + + + + + + + + A A + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M M I|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + M + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X X X|
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + M M + + M +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X X X X X X X X X|
Fibroadenoma, Multiple | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X X X|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | M + M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + A A + + + + + + + + A +| 46 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + M + + + + + A| 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + M + M + + + + +| 43 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + I + + + A + + I + + A A + + A + + + + + A A| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + + + A + + + + + A + + + + + + + + + A A| 38 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 29 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + A +| 48 |
Leukemia Mononuclear | X X X X | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + I + + + + + + + + + A + + + + + + + + + A +| 44 |
Leukemia Mononuclear | X | 2 |
Pheochromocytoma Benign | X X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + M + + + M + + + + + + I| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Carcinoma | | 3 |
Pars Distalis, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Adenoma | X | 4 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Malignant | | 1 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Polyp Stromal | X X X X | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mesenteric, Leukemia Mononuclear | X | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + M + +| 46 |
Leukemia Mononuclear | X X X X X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Monocytic | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X | 32 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + M + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibroadenoma | X X X X | 14 |
Fibroadenoma, Multiple | X X X | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 1 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 3 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X | 17 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + I +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + | 7 |
__________________________________________________________________________|____________|
Zymbal's Gland | +| 2 |
Carcinoma | X| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Monocytic | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X | 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + I + + + + + I + + + + + + I + + A + + + A + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + I + A + A + + + A + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + I + + + + + + + + A + A + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X|
Leukemia Mononuclear | X X X X X X X X X X X X |
Neoplastic Nodule | X X |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Pharynx | |
Palate, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X X X |
Pheochromocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X X X X X X X X X X X |
Bilateral, Pheochromocytoma Malignant| |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + M M + + +|
Adenoma | X X |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + I + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lipoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Bilateral, Tunic, Mesothelioma | |
Malignant | X |
Interstitial Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X X X X X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Thymus | M + + + M + + + M M + + M + + + + + + + + + M + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M + + M + + M + M M M M + + + M + + M +|
Fibroadenoma | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Trichoepithelioma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibroma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X |
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + I + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | + +|
Carcinoma | X X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Lymphoma Malignant | X |
Lymphoma Malignant Histiocytic | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + I + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + I + A + + A + + + +| 42 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A A + A + + A + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X | 2 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 26 |
Neoplastic Nodule | | 2 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 5 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X| 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X| 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + I M + + + + + M + M M| 42 |
Leukemia Mononuclear | X X X X | 11 |
Pheochromocytoma Malignant | X X | 3 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | X X X X X | 16 |
Bilateral, Pheochromocytoma Malignant| X | 1 |
Bilateral, Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | I + + + + + + + + + + + + + + + M + + + + M + M I| 42 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X| 25 |
Pars Distalis, Carcinoma | X | 1 |
Pars Distalis, Leukemia Mononuclear | X X X X X| 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
C-Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Lipoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 7 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X| 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X | 22 |
Bilateral, Tunic, Mesothelioma | | |
Malignant | | 1 |
Interstitial Cell, Adenoma | X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X| 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mesenteric, Leukemia Mononuclear | X| 8 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 16 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + + + +| 47 |
Leukemia Mononuclear | X X X X| 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X| 28 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + M + M + + + M M + + + + + + + +| 39 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M + + M + M M + M M M M M M + M M + + M| 21 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Basal Cell Carcinoma | | 1 |
Trichoepithelioma | X | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma NOS | | 1 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X| 21 |
Lymphoma Malignant | | 1 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X| 14 |
__________________________________________________________________________|____________|
Harderian Gland | +| 7 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 20 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X| 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X| 29 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + A + A + + + + + + A + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + A M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + I + + + + + I + + + A + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | A + A + A + A + + + + A + + I|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + A + A + A + + + + A + A I|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + M + + M + + + +|
Leukemia Mononuclear | X X X X X X X X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X X |
Pars Distalis, Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X X|
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenoma | |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
Tunic, Mesothelioma Benign | X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + I + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + I M + + M + + + + + M + M|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | I + + + M + + + + + + + M + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M + + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | A + + + + + + + + + + A + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + A + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X X |
Leukemia Mononuclear | X X X X X X X X X X X X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
Mesothelioma Benign | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + M + + + + I + + + + + I + +| 26 |
Leukemia Mononuclear | X| 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + M + + + + + + + + + + +| 32 |
Leukemia Mononuclear | X X X| 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + I + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + I + + + + + + + +| 30 |
Leukemia Mononuclear | X| 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A A M I + + + I + + + + + + + +| 22 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + M + A A + + + I + A + + + A A A| 18 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | X | 2 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 35 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X X X| 7 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X X| 7 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X| 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 32 |
Leukemia Mononuclear | X X X| 4 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + +| 35 |
Leukemia Mononuclear | X X X X X X X X| 17 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X| 17 |
Pheochromocytoma Benign | X X X X X X X | 12 |
Bilateral, Pheochromocytoma Benign | X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 36 |
Adenoma | X | 5 |
Carcinoma | | 1 |
Leukemia Mononuclear | X| 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +| 32 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 43 |
Pars Distalis, Adenoma | X X X X X X X X X X X | 25 |
Pars Distalis, Carcinoma | X | 3 |
Pars Distalis, Leukemia Mononuclear | X X X X X X X| 14 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, C-Cell, Adenoma | X | 1 |
C-Cell, Adenoma | X X X | 8 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + M + + +| 32 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Adenoma | X X | 2 |
Carcinoma | X | 1 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + +| 34 |
Leukemia Mononuclear | X X X| 3 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X| 3 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X | 26 |
Interstitial Cell, Adenoma | X X X X X X | 12 |
Tunic, Mesothelioma Benign | | 1 |
Tunic, Mesothelioma Malignant | X X| 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 33 |
Leukemia Mononuclear | X X X X X X| 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 35 |
Axillary, Leukemia Mononuclear | X | 1 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X| 5 |
Mesenteric, Leukemia Mononuclear | X X X X X X| 7 |
Renal, Leukemia Mononuclear | X X X| 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + M + + + + + + + + + + + +| 29 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X X X X X X X X| 15 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + +| 27 |
Leukemia Mononuclear | X X X X X X| 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 33 |
__________________________________________________________________________|____________|
Thymus | + + M + M M + + + + + + + + + + + M| 26 |
Leukemia Mononuclear | X X X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M + + M M + + + M +| 10 |
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + +| 32 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 33 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 33 |
Astrocytoma NOS | X | 1 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 2 |
Carcinoma, Metastatic, Zymbal's Gland| X | 1 |
Leukemia Mononuclear | X X X X X X| 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | A + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Leukemia Mononuclear | X X X X X X X X X X X X X X| 26 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X| 15 |
__________________________________________________________________________|____________|
Trachea | A + + + + + + I + + + + + + + + + I| 29 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Leukemia Mononuclear | X X X X X X X X X X X| 22 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + I + + + + + + + +| 31 |
Leukemia Mononuclear | X X X| 7 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X| 35 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | X X| 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | I + + + + + M + + I + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + A I|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + I + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + A + + I + + + A I|
__________________________________________________________________________|
Intestine Small, Jejunum | A A A A + + A I + I + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + M + A + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Pharynx | |
Palate, Adenoma | |
Palate, Papilloma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + I + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + A + + + + + +|
Adenoma | X X |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | X |
Pars Distalis, Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + A + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + A + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X|
Mesenteric, Leukemia Mononuclear | X X X|
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + A + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + M + + + + A M + + + + +|
Leukemia Mononuclear | X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + + + M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X X X |
Squamous Cell Papilloma | X |
Sebaceous Gland, Adenoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Intestine Large | A A + + + A + + + + A + + +| 24 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + + + A + + + + A + + +| 21 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + + A + + + + A + + +| 24 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A M + + + A + + M M M + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small | A A + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A + + + + + M I + + + + I| 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + A + A I I + + + +| 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + I + A A + + I A + I I| 12 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X| 28 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + +| 26 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Pharynx | + + | 2 |
Palate, Adenoma | X | 1 |
Palate, Papilloma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | A + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Stomach | A + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + +| 30 |
Leukemia Mononuclear | X X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X| 21 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X| 17 |
Pheochromocytoma Malignant | X X | 4 |
Pheochromocytoma Benign | X X X X | 10 |
Bilateral, Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + +| 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 2 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 40 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X | 25 |
Pars Distalis, Carcinoma | X | 2 |
Pars Distalis, Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
C-Cell, Adenoma | X X X X X X| 7 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + + I + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + A M + + + + + + + + + + + + + + + + + + + + +| 46 |
Adenoma | X | 2 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | A + + + + + + + + + + + + +| 27 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 6 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X | 26 |
Interstitial Cell, Adenoma | X X X X X| 10 |
Tunic, Mesothelioma Malignant | X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | A A + + + + + + + + + + + +| 26 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Lymph Node | M A + + + + + + + + + + + + +| 30 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 2 |
Mesenteric, Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + + + + + + + + +| 25 |
Leukemia Mononuclear | X X X X X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | A + + + + + + + + + + + + +| 28 |
Leukemia Mononuclear | X X X X X X X| 12 |
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X| 30 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + +| 25 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M + M + + M M +| 12 |
__________________________________________________________________________|____________|
Skin | A + + + + + + + + + + + + +| 30 |
Keratoacanthoma | | 3 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + +| 30 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | A + + + + + + + + + A + + +| 25 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X| 26 |
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Trachea | A + + + + + + + + + A + + +| 26 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + +| 39 |
Leukemia Mononuclear | X X X X X| 13 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + +| 27 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X| 30 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + A + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + A + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + A + + + A + + + + + A + + + + + + + + A + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Kidney | |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | X |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + I M + M + + + + + + + + M + + + + M M + M + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + M + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M + M + + I + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + M + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + I + I + + M|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + A + + + + + + + + + + +|
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + A + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + I + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
__________________________________________________________________________|
Thymus | M + + + + + + + M + + + + A M M + M + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M + + M + M + + M M M + + + + + M + M + M|
Fibroadenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | |
Carcinoma, Metastatic, Kidney | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Leukemia Mononuclear | X |
Oligodendroglioma Malignant | |
Meninges, Carcinoma, Metastatic, | |
Zymbal's Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X X X X X X X X |
Mesothelioma Malignant, Metastatic, | |
Testes | X |
Pheochromocytoma Malignant, | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Submucosa, Adenocarcinoma | |
Vomeronasal Organ, Squamous Cell | |
Carcinoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Harderian Gland | |
Adenocarcinoma | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M A + + + + + + + + + + + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + M + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + M + + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + I + + + + + + + + + + A + + I + + + + +| 43 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + + A A + + M + + + + + + + + +| 39 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 25 |
Neoplastic Nodule | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Carcinoma, Metastatic, Kidney | X | 1 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma, Metastatic, Kidney | X | 1 |
Leukemia Mononuclear | X X | 3 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Pharynx | + + + | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + M M + + + M + + + + + M +| 38 |
Leukemia Mononuclear | X X X X | 7 |
Pheochromocytoma Malignant | X X | 3 |
Pheochromocytoma Benign | X X X X | 12 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M M + + + + + + M + + + + + + + + + M| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Pars Distalis, Adenoma | X X X X X X X X X X| 25 |
Pars Distalis, Carcinoma | X X | 2 |
Pars Distalis, Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Adenoma | X X X | 6 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + M + + + + + + + I + + + + + M M + + + + + I + +| 42 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 3 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X | 30 |
Interstitial Cell, Adenoma | X X X X X | 11 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mesenteric, Leukemia Mononuclear | X X | 3 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
Carcinoma, Metastatic, Kidney | X | 1 |
Leukemia Mononuclear | X X X X X X | 10 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + I + + + + + + + + + + + + + M| 46 |
Leukemia Mononuclear | X X X X X X X | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 26 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + M M + M + + + + + + + M +| 39 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M M M M + M + + M + + M + M + I + M +| 24 |
Fibroadenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X X | 3 |
Subcutaneous Tissue, Fibroma | X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Carcinoma, Metastatic, Kidney | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pituitary | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Gland | X | 1 |
Leukemia Mononuclear | X X X X X | 6 |
Oligodendroglioma Malignant | X | 1 |
Meninges, Carcinoma, Metastatic, | | |
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Kidney | X | 1 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 21 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
Submucosa, Adenocarcinoma | X | 1 |
Vomeronasal Organ, Squamous Cell | | |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Trachea | + I + + + + + + + + + + M + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X | 15 |
Renal Tubule, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05096-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:20
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X | 28 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
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