TDMS Study 05096-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
0-CHLOROBENZALMALONONITRILE (CS-2)
NTP Experiment-Test: 05096-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
Facility: Battelle Northwest
Chemical CAS #: 2698-41-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Dead 7 5 9 4
Moribund 23 21 12 19
Survivors
Terminal Sacrifice 20 24 29 27
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (40) (20) (10) (46)
Intestine Large, Colon (45) (20) (15) (47)
Intestine Large, Rectum (47) (23) (14) (43)
Adenoma 1 (2%)
Intestine Small, Ileum (31) (18) (4) (40)
Leiomyosarcoma 1 (3%)
Liver (49) (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Neoplasm NOS, Metastatic, Adrenal Gland 1 (2%)
Neoplastic Nodule 3 (6%)
Mesentery (4) (4) (2)
Pancreas (49) (25) (19) (50)
Salivary Glands (49) (25) (19) (50)
Stomach, Forestomach (48) (33) (21) (50)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (31) (20) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (28) (21) (50)
Sarcoma, Metastatic, Skin 1 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (25) (23) (48)
Adenoma 2 (4%) 2 (9%)
Carcinoma 1 (4%)
Adrenal Gland, Medulla (37) (21) (18) (44)
Pheochromocytoma Benign 5 (14%) 2 (10%) 3 (17%) 6 (14%)
Bilateral, Pheochromocytoma Malignant 1 (5%)
Bilateral, Pheochromocytoma Benign 1 (5%)
Page 2
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (48) (24) (20) (49)
Adenoma 1 (5%)
Carcinoma 1 (2%) 1 (5%)
Parathyroid Gland (40) (22) (18) (43)
Pituitary Gland (48) (44) (42) (49)
Pars Distalis, Adenoma 28 (58%) 26 (59%) 32 (76%) 32 (65%)
Pars Distalis, Carcinoma 2 (4%) 3 (7%) 2 (5%) 3 (6%)
Thyroid Gland (48) (26) (18) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 4 (8%) 2 (8%) 2 (4%)
C-Cell, Carcinoma 1 (2%) 1 (4%)
Follicular Cell, Adenoma 1 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (25) (21) (48)
Adenoma 4 (8%) 6 (24%) 1 (5%) 4 (8%)
Duct, Carcinoma 1 (2%)
Ovary (49) (49) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Neoplasm NOS, Metastatic, Adrenal Gland 1 (2%)
Uterus (49) (31) (23) (50)
Deciduoma Benign 1 (2%)
Polyp Stromal 4 (8%) 7 (23%) 5 (22%) 8 (16%)
Polyp Stromal, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (26) (19) (49)
Lymph Node (49) (48) (49) (50)
Mediastinal, Carcinoma, Metastatic, Thyroid
Gland 1 (2%)
Lymph Node, Bronchial (47) (47) (47) (46)
Neoplasm NOS, Metastatic, Adrenal Gland 1 (2%)
Lymph Node, Mandibular (45) (25) (19) (47)
Fibrous Histiocytoma, Metastatic, Skin 1 (4%)
Spleen (49) (50) (49) (50)
Neoplasm NOS, Metastatic, Adrenal Gland 1 (2%)
Page 3
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Thymus (44) (23) (20) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (49) (49)
Adenocarcinoma 1 (2%) 2 (4%) 1 (2%)
Adenoma 1 (2%)
Fibroadenoma 15 (31%) 11 (22%) 13 (27%) 14 (29%)
Fibroadenoma, Multiple 1 (2%) 3 (6%)
Skin (50) (33) (30) (50)
Basal Cell Adenoma 1 (3%)
Basal Cell Carcinoma 1 (3%)
Keratoacanthoma 1 (3%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (3%)
Subcutaneous Tissue, Fibrosarcoma 1 (3%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (29) (21) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (28) (21) (50)
Carcinoma, Metastatic, Pituitary Gland 2 (4%) 3 (11%) 2 (10%) 3 (6%)
Glioma NOS 1 (5%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%)
Carcinoma, Metastatic, Adrenal Gland 1 (2%)
Neoplasm NOS, Metastatic, Adrenal Gland 1 (2%)
Nose (49) (49) (49) (50)
Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (48) (5) (3) (49)
Zymbal's Gland (1) (2)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (37) (30) (50)
Neoplasm NOS, Metastatic, Adrenal Gland 1 (3%)
Renal Tubule, Adenoma 2 (7%)
Urinary Bladder (47) (24) (20) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 24 (48%) 24 (48%) 21 (42%) 33 (66%)
Lymphoma Malignant Histiocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 47 47 50
Total Primary Neoplasms 104 94 94 113
Total Animals with Benign Neoplasms 41 35 40 43
Total Benign Neoplasms 73 58 63 72
Total Animals with Malignant Neoplasms 28 32 29 37
Total Malignant Neoplasms 31 36 30 41
Total Animals with Metastatic Neoplasms 2 8 2 4
Total Metastatic Neoplasm 2 13 2 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund 19 27 21 20
Dead 5 6 8 4
Survivors
Terminal Sacrifice 26 17 21 26
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (44) (26) (21) (44)
Intestine Large, Colon (48) (32) (24) (46)
Intestine Small, Duodenum (50) (30) (23) (46)
Intestine Small, Ileum (42) (22) (18) (43)
Intestine Small, Jejunum (41) (18) (12) (39)
Liver (50) (50) (49) (50)
Hepatocellular Carcinoma 2 (4%)
Hepatocellular Adenoma 2 (4%)
Neoplastic Nodule 2 (4%) 1 (2%) 2 (4%)
Mesentery (5) (3) (2) (4)
Carcinoma, Metastatic, Kidney 1 (25%)
Pancreas (50) (33) (26) (48)
Carcinoma, Metastatic, Kidney 1 (2%)
Pharynx (1) (1) (2) (4)
Palate, Adenoma 1 (100%) 1 (50%)
Palate, Papilloma 1 (50%)
Salivary Glands (49) (33) (27) (49)
Stomach, Forestomach (50) (33) (28) (50)
Stomach, Glandular (50) (32) (28) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (35) (30) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (48) (49)
Adenoma 1 (2%) 1 (2%) 1 (2%)
Adrenal Gland, Medulla (42) (46) (47) (38)
Pheochromocytoma Malignant 3 (7%) 4 (9%) 3 (8%)
Pheochromocytoma Complex 1 (2%)
Page 7
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 16 (38%) 12 (26%) 10 (21%) 12 (32%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Bilateral, Pheochromocytoma Benign 2 (5%) 5 (11%) 3 (6%) 1 (3%)
Islets, Pancreatic (50) (36) (27) (48)
Adenoma 1 (2%) 5 (14%) 2 (7%) 2 (4%)
Carcinoma 1 (3%) 2 (7%)
Parathyroid Gland (42) (32) (27) (41)
Adenoma 2 (5%) 1 (3%)
Pituitary Gland (47) (43) (40) (47)
Pars Distalis, Adenoma 25 (53%) 25 (58%) 25 (63%) 25 (53%)
Pars Distalis, Carcinoma 1 (2%) 3 (7%) 2 (5%) 2 (4%)
Thyroid Gland (48) (49) (46) (48)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 2 (4%) 8 (16%) 7 (15%) 6 (13%)
C-Cell, Carcinoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Lipoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (48) (46) (50)
Adenoma 3 (6%) 2 (4%) 2 (4%) 3 (6%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Prostate (50) (34) (27) (50)
Seminal Vesicle (7) (3) (6) (8)
Testes (50) (47) (50) (50)
Bilateral, Interstitial Cell, Adenoma 22 (44%) 26 (55%) 26 (52%) 30 (60%)
Interstitial Cell, Adenoma 9 (18%) 12 (26%) 10 (20%) 11 (22%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (33) (26) (49)
Lymph Node (50) (35) (30) (49)
Lymph Node, Bronchial (50) (29) (25) (47)
Carcinoma, Metastatic, Kidney 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
Lymph Node, Mandibular (47) (27) (28) (46)
Spleen (50) (49) (49) (50)
Thymus (39) (26) (25) (39)
Page 8
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (21) (10) (12) (24)
Fibroadenoma 1 (5%) 1 (4%)
Skin (49) (32) (30) (50)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (3%) 3 (10%) 3 (6%)
Squamous Cell Papilloma 1 (3%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Adenoma 1 (3%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (3%) 3 (6%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (33) (29) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
Carcinoma, Metastatic, Kidney 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (33) (30) (50)
Astrocytoma NOS 1 (2%) 1 (3%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 2 (6%) 1 (3%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (3%)
Oligodendroglioma Malignant 1 (2%)
Meninges, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%)
Carcinoma, Metastatic, Kidney 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Nose (50) (50) (49) (50)
Page 9
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Submucosa, Adenocarcinoma 1 (2%)
Vomeronasal Organ, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (48) (6) (4) (49)
Harderian Gland (7) (1)
Adenocarcinoma 1 (100%)
Zymbal's Gland (2) (1) (1)
Carcinoma 2 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (44) (39) (50)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 1 (3%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (49) (31) (27) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 29 (58%) 35 (70%) 30 (60%) 28 (56%)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 1 (2%) 2 (4%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05096-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 0-CHLOROBENZALMALONONITRILE (CS-2) Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:59:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL .075 MG/ 0.25 MG/ 0.75 MG/
M3 M3 M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 50 50
Total Primary Neoplasms 141 156 140 143
Total Animals with Benign Neoplasms 46 45 47 48
Total Benign Neoplasms 96 107 96 101
Total Animals with Malignant Neoplasms 33 42 37 37
Total Malignant Neoplasms 44 48 44 42
Total Animals with Metastatic Neoplasms 2 4 1 5
Total Metastatic Neoplasm 2 4 1 14
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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