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TDMS Study 05096-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 0-CHLOROBENZALMALONONITRILE (CS-2)


NTP Experiment-Test: 05096-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05




       Facility:  Battelle Northwest

       Chemical CAS #:  2698-41-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                               7            5            9            4                                     
    Moribund                                          23           21           12           19                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           24           29           27                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (40)         (20)         (10)         (46)                                   
   Intestine Large, Colon                             (45)         (20)         (15)         (47)                                   
   Intestine Large, Rectum                            (47)         (23)         (14)         (43)                                   
      Adenoma                                                                                 1 (2%)                                
   Intestine Small, Ileum                             (31)         (18)         (4)          (40)                                   
      Leiomyosarcoma                                   1 (3%)                                                                       
   Liver                                              (49)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Neoplasm NOS, Metastatic, Adrenal Gland                       1 (2%)                                                          
      Neoplastic Nodule                                3 (6%)                                                                       
   Mesentery                                          (4)          (4)          (2)                                                 
   Pancreas                                           (49)         (25)         (19)         (50)                                   
   Salivary Glands                                    (49)         (25)         (19)         (50)                                   
   Stomach, Forestomach                               (48)         (33)         (21)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (31)         (20)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (28)         (21)         (50)                                   
      Sarcoma, Metastatic, Skin                                     1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (25)         (23)         (48)                                   
      Adenoma                                          2 (4%)                    2 (9%)                                             
      Carcinoma                                                     1 (4%)                                                          
   Adrenal Gland, Medulla                             (37)         (21)         (18)         (44)                                   
      Pheochromocytoma Benign                          5 (14%)      2 (10%)      3 (17%)      6 (14%)                               
      Bilateral, Pheochromocytoma Malignant                         1 (5%)                                                          
      Bilateral, Pheochromocytoma Benign                            1 (5%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (48)         (24)         (20)         (49)                                   
      Adenoma                                                                    1 (5%)                                             
      Carcinoma                                        1 (2%)                    1 (5%)                                             
   Parathyroid Gland                                  (40)         (22)         (18)         (43)                                   
   Pituitary Gland                                    (48)         (44)         (42)         (49)                                   
      Pars Distalis, Adenoma                          28 (58%)     26 (59%)     32 (76%)     32 (65%)                               
      Pars Distalis, Carcinoma                         2 (4%)       3 (7%)       2 (5%)       3 (6%)                                
   Thyroid Gland                                      (48)         (26)         (18)         (50)                                   
      Bilateral, C-Cell, Adenoma                                                              1 (2%)                                
      C-Cell, Adenoma                                  4 (8%)       2 (8%)                    2 (4%)                                
      C-Cell, Carcinoma                                1 (2%)       1 (4%)                                                          
      Follicular Cell, Adenoma                                      1 (4%)                                                          
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (25)         (21)         (48)                                   
      Adenoma                                          4 (8%)       6 (24%)      1 (5%)       4 (8%)                                
      Duct, Carcinoma                                  1 (2%)                                                                       
   Ovary                                              (49)         (49)         (50)         (50)                                   
      Granulosa Cell Tumor Malignant                                             1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Neoplasm NOS, Metastatic, Adrenal Gland                       1 (2%)                                                          
   Uterus                                             (49)         (31)         (23)         (50)                                   
      Deciduoma Benign                                 1 (2%)                                                                       
      Polyp Stromal                                    4 (8%)       7 (23%)      5 (22%)      8 (16%)                               
      Polyp Stromal, Multiple                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (26)         (19)         (49)                                   
   Lymph Node                                         (49)         (48)         (49)         (50)                                   
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                     1 (2%)                                                          
   Lymph Node, Bronchial                              (47)         (47)         (47)         (46)                                   
      Neoplasm NOS, Metastatic, Adrenal Gland                       1 (2%)                                                          
   Lymph Node, Mandibular                             (45)         (25)         (19)         (47)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (4%)                                                          
   Spleen                                             (49)         (50)         (49)         (50)                                   
      Neoplasm NOS, Metastatic, Adrenal Gland                       1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (44)         (23)         (20)         (47)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (49)         (49)                                   
      Adenocarcinoma                                   1 (2%)       2 (4%)       1 (2%)                                             
      Adenoma                                                       1 (2%)                                                          
      Fibroadenoma                                    15 (31%)     11 (22%)     13 (27%)     14 (29%)                               
      Fibroadenoma, Multiple                           1 (2%)                                 3 (6%)                                
   Skin                                               (50)         (33)         (30)         (50)                                   
      Basal Cell Adenoma                                                         1 (3%)                                             
      Basal Cell Carcinoma                                                       1 (3%)                                             
      Keratoacanthoma                                                            1 (3%)       1 (2%)                                
      Subcutaneous Tissue, Fibroma                                               1 (3%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (3%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (29)         (21)         (50)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (28)         (21)         (50)                                   
      Carcinoma, Metastatic, Pituitary Gland           2 (4%)       3 (11%)      2 (10%)      3 (6%)                                
      Glioma NOS                                                                 1 (5%)                                             
      Granular Cell Tumor Benign                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             2 (4%)                                             
      Carcinoma, Metastatic, Adrenal Gland                          1 (2%)                                                          
      Neoplasm NOS, Metastatic, Adrenal Gland                       1 (2%)                                                          
   Nose                                               (49)         (49)         (49)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (48)         (5)          (3)          (49)                                   
   Zymbal's Gland                                                  (1)                       (2)                                    
      Carcinoma                                                     1 (100%)                  2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (37)         (30)         (50)                                   
      Neoplasm NOS, Metastatic, Adrenal Gland                       1 (3%)                                                          
      Renal Tubule, Adenoma                                                      2 (7%)                                             
   Urinary Bladder                                    (47)         (24)         (20)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Monocytic                                                                      1 (2%)                                
      Leukemia Mononuclear                            24 (48%)     24 (48%)     21 (42%)     33 (66%)                               
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          47          47          50                                       
     Total Primary Neoplasms                          104          94          94         113                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          35          40          43                                       
     Total Benign Neoplasms                            73          58          63          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          32          29          37                                       
     Total Malignant Neoplasms                         31          36          30          41                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           8           2           4                                       
     Total Metastatic Neoplasm                          2          13           2           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           27           21           20                                     
    Dead                                               5            6            8            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           17           21           26                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (44)         (26)         (21)         (44)                                   
   Intestine Large, Colon                             (48)         (32)         (24)         (46)                                   
   Intestine Small, Duodenum                          (50)         (30)         (23)         (46)                                   
   Intestine Small, Ileum                             (42)         (22)         (18)         (43)                                   
   Intestine Small, Jejunum                           (41)         (18)         (12)         (39)                                   
   Liver                                              (50)         (50)         (49)         (50)                                   
      Hepatocellular Carcinoma                         2 (4%)                                                                       
      Hepatocellular Adenoma                                        2 (4%)                                                          
      Neoplastic Nodule                                2 (4%)       1 (2%)                    2 (4%)                                
   Mesentery                                          (5)          (3)          (2)          (4)                                    
      Carcinoma, Metastatic, Kidney                                                           1 (25%)                               
   Pancreas                                           (50)         (33)         (26)         (48)                                   
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
   Pharynx                                            (1)          (1)          (2)          (4)                                    
      Palate, Adenoma                                  1 (100%)                  1 (50%)                                            
      Palate, Papilloma                                                          1 (50%)                                            
   Salivary Glands                                    (49)         (33)         (27)         (49)                                   
   Stomach, Forestomach                               (50)         (33)         (28)         (50)                                   
   Stomach, Glandular                                 (50)         (32)         (28)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (35)         (30)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (48)         (49)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
   Adrenal Gland, Medulla                             (42)         (46)         (47)         (38)                                   
      Pheochromocytoma Malignant                       3 (7%)                    4 (9%)       3 (8%)                                
      Pheochromocytoma Complex                         1 (2%)                                                                       
                                                             Page   7                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                         16 (38%)     12 (26%)     10 (21%)     12 (32%)                               
      Bilateral, Pheochromocytoma Malignant            1 (2%)                                                                       
      Bilateral, Pheochromocytoma Benign               2 (5%)       5 (11%)      3 (6%)       1 (3%)                                
   Islets, Pancreatic                                 (50)         (36)         (27)         (48)                                   
      Adenoma                                          1 (2%)       5 (14%)      2 (7%)       2 (4%)                                
      Carcinoma                                                     1 (3%)       2 (7%)                                             
   Parathyroid Gland                                  (42)         (32)         (27)         (41)                                   
      Adenoma                                          2 (5%)       1 (3%)                                                          
   Pituitary Gland                                    (47)         (43)         (40)         (47)                                   
      Pars Distalis, Adenoma                          25 (53%)     25 (58%)     25 (63%)     25 (53%)                               
      Pars Distalis, Carcinoma                         1 (2%)       3 (7%)       2 (5%)       2 (4%)                                
   Thyroid Gland                                      (48)         (49)         (46)         (48)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  2 (4%)       8 (16%)      7 (15%)      6 (13%)                               
      C-Cell, Carcinoma                                             1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Lipoma                                           1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (50)         (48)         (46)         (50)                                   
      Adenoma                                          3 (6%)       2 (4%)       2 (4%)       3 (6%)                                
      Carcinoma                                                     1 (2%)       1 (2%)       1 (2%)                                
   Prostate                                           (50)         (34)         (27)         (50)                                   
   Seminal Vesicle                                    (7)          (3)          (6)          (8)                                    
   Testes                                             (50)         (47)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           22 (44%)     26 (55%)     26 (52%)     30 (60%)                               
      Interstitial Cell, Adenoma                       9 (18%)     12 (26%)     10 (20%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (33)         (26)         (49)                                   
   Lymph Node                                         (50)         (35)         (30)         (49)                                   
   Lymph Node, Bronchial                              (50)         (29)         (25)         (47)                                   
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (3%)                                                          
   Lymph Node, Mandibular                             (47)         (27)         (28)         (46)                                   
   Spleen                                             (50)         (49)         (49)         (50)                                   
   Thymus                                             (39)         (26)         (25)         (39)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (21)         (10)         (12)         (24)                                   
      Fibroadenoma                                     1 (5%)                                 1 (4%)                                
   Skin                                               (49)         (32)         (30)         (50)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                               1 (3%)       3 (10%)      3 (6%)                                
      Squamous Cell Papilloma                                                    1 (3%)                                             
      Trichoepithelioma                                1 (2%)                                                                       
      Sebaceous Gland, Adenoma                                                   1 (3%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (3%)                    3 (6%)                                
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (33)         (29)         (50)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                                              (1)          (1)                                    
      Carcinoma, Metastatic, Kidney                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (33)         (30)         (50)                                   
      Astrocytoma NOS                                  1 (2%)       1 (3%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)       2 (6%)       1 (3%)       1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                         1 (3%)                                                          
      Oligodendroglioma Malignant                                                             1 (2%)                                
      Meninges, Carcinoma, Metastatic, Zymbal's                                                                                     
          Gland                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       2 (4%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                2 (4%)                                                          
      Carcinoma, Metastatic, Kidney                                                           1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                       1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
   Nose                                               (50)         (50)         (49)         (50)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
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         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
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RESPIRATORY SYSTEM - cont                                                                                                           
      Submucosa, Adenocarcinoma                                                               1 (2%)                                
      Vomeronasal Organ, Squamous Cell Carcinoma                                              1 (2%)                                
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (48)         (6)          (4)          (49)                                   
   Harderian Gland                                    (7)                                    (1)                                    
      Adenocarcinoma                                                                          1 (100%)                              
   Zymbal's Gland                                     (2)          (1)                       (1)                                    
      Carcinoma                                        2 (100%)     1 (100%)                  1 (100%)                              
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (44)         (39)         (50)                                   
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       1 (3%)                                             
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (49)         (31)         (27)         (49)                                   
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 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            29 (58%)     35 (70%)     30 (60%)     28 (56%)                               
      Lymphoma Malignant                               1 (2%)                                                                       
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Mesothelioma Benign                                           1 (2%)                                                          
      Mesothelioma Malignant                           1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05096-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 0-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:59:05  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      .075 MG/     0.25 MG/     0.75 MG/                                  
                                                                M3           M3           M3                                        
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49          50          50                                       
     Total Primary Neoplasms                          141         156         140         143                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          45          47          48                                       
     Total Benign Neoplasms                            96         107          96         101                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          42          37          37                                       
     Total Malignant Neoplasms                         44          48          44          42                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4           1           5                                       
     Total Metastatic Neoplasm                          2           4           1          14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1                                                               
     Total Uncertain Neoplasms                          1           1                                                               
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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