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TDMS Study 05096-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                            0-CHLOROBENZALMALONONITRILE (CS-2)                          DATE: 09/13/94       
EXPERIMENT: 05096 TEST: 01                                                                                     TIME: 02:13:43       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-38061          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 55118        
PATHOLOGIST: R. MILLER                                                                                         CAS: 2698-41-1       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Battelle Northwest                            0-CHLOROBENZALMALONONITRILE (CS-2)                          DATE: 09/13/94      
EXPERIMENT: 05096 TEST: 01                                                                                     TIME: 02:13:43      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-38061          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 55118       
PATHOLOGIST: R. MILLER                                                                                         CAS: 2698-41-1      
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                            0-CHLOROBENZALMALONONITRILE (CS-2)                          DATE: 09/13/94       
EXPERIMENT: 05096 TEST: 01                                                                                     TIME: 02:13:43       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-38061          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 55118        
PATHOLOGIST: R. MILLER                                                                                         CAS: 2698-41-1       
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                               IN THE ANALYSIS OF THE STUDY OF 0-CHLOROBENZALMALONONITRILE (CS-2)
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Islets, Pancreatic            Adenoma
                                                           Carcinoma
                                                           Carcinoma or Adenoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Testes                        Adenoma
                             Thyroid Gland: C-Cell         Adenoma
                                                           Carcinoma or Adenoma
                             All Organs                    Malignant Tumors
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Clitoral/Preputial Gland      Adenoma
                                                           Carcinoma or Adenoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Malignant Tumors
 
              ====================================================================================================
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   1
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    1/48 (2%)    1/49 (2%)  |  2/49 (4%)    0/25 (0%)    2/23 (9%)    0/48 (0%)  |
|ADJUSTED (b)           |   3.8%         0.0%         4.8%         3.8%      |   6.3%         0.0%        35.4%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    1/21 (5%)    1/26 (4%)  |  0/20 (0%)    0/2 (0%)     1/3 (33%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      ---          749 (T)      749 (T)   |   588          ---          709          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.588      P=0.585N     P=0.714      P=0.762    |  P=0.217N     P=0.219N     P=0.614      P=0.216N   |
|INCIDENTAL TUMOR       |  P=0.588      P=0.585N     P=0.714      P=0.762    |  P=0.287N     P=0.314N     P=0.402      P=0.326N   |
|LOGISTIC REGRESSION    |  P=0.588      P=0.585N     P=0.714      P=0.762    |  P=0.217N     P=0.375N     P=0.345      P=0.257N   |
|COCHRAN-ARMITAGE       |  P=0.539                                           |  P=0.241N                                          |
|FISHER EXACT           |               P=0.500N     P=0.742      P=0.747    |               P=0.435N     P=0.382      P=0.253N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 18/42 (43%)  17/46 (37%)  13/47 (28%)  13/38 (34%) |  5/37 (14%)   3/21 (14%)   3/18 (17%)   6/44 (14%) |
|ADJUSTED (b)           |  60.6%        67.3%        43.3%        39.5%      |  19.4%         8.5%        52.8%        20.1%      |
|TERMINAL (d)           | 12/23 (52%)   8/15 (53%)   6/21 (29%)   6/23 (26%) |  2/19 (11%)   0/2 (0%)     1/2 (50%)    4/27 (15%) |
|FIRST INCIDENCE (DAYS) |   585          586          599          473       |   465          602          639          662       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.092N     P=0.257      P=0.296N     P=0.193N   |  P=0.512N     P=0.525N     P=0.650N     P=0.586N   |
|INCIDENTAL TUMOR       |  P=0.259N     P=0.394N     P=0.097N     P=0.225N   |  P=0.555      P=0.629N     P=0.523      P=0.518    |
|LOGISTIC REGRESSION    |  P=0.218N     P=0.483N     P=0.124N     P=0.241N   |  P=0.501N     P=0.639      P=0.494      P=0.628    |
|COCHRAN-ARMITAGE       |  P=0.308N                                          |  P=0.559N                                          |
|FISHER EXACT           |               P=0.364N     P=0.100N     P=0.287N   |               P=0.612      P=0.524      P=0.623    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   2
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/42 (10%)   0/46 (0%)    4/47 (9%)    3/38 (8%)  |  0/37 (0%)    1/21 (5%)    0/18 (0%)    0/44 (0%)  |
|ADJUSTED (b)           |  17.4%         0.0%        14.3%        10.9%      |   0.0%         3.6%         0.0%         0.0%      |
|TERMINAL (d)           |  4/23 (17%)   0/15 (0%)    2/21 (10%)   2/23 (9%)  |  0/19 (0%)    0/2 (0%)     0/2 (0%)     0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      ---          452          638       |   ---          720          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.554      P=0.125N     P=0.602      P=0.490N   |  P=0.565N     P=0.548        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.489      P=0.125N     P=0.618N     P=0.543N   |  P=0.628N     P=0.479        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.426      P=0.125N     P=0.596N     P=0.520N   |  P=0.468N     P=0.303        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.403                                           |  P=0.499N                                          |
|FISHER EXACT           |               P=0.048N*    P=0.578N     P=0.557N   |               P=0.362        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/42 (48%)  17/46 (37%)  16/47 (34%)  15/38 (39%) |  5/37 (14%)   4/21 (19%)   3/18 (17%)   6/44 (14%) |
|ADJUSTED (b)           |  65.0%        67.3%        49.8%        44.5%      |  19.4%        11.8%        52.8%        20.1%      |
|TERMINAL (d)           | 13/23 (57%)   8/15 (53%)   7/21 (33%)   7/23 (30%) |  2/19 (11%)   0/2 (0%)     1/2 (50%)    4/27 (15%) |
|FIRST INCIDENCE (DAYS) |   569          586          452          473       |   465          602          639          662       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.126N     P=0.392      P=0.385N     P=0.196N   |  P=0.450N     P=0.636      P=0.650N     P=0.586N   |
|INCIDENTAL TUMOR       |  P=0.367N     P=0.242N     P=0.136N     P=0.271N   |  P=0.555N     P=0.523      P=0.523      P=0.518    |
|LOGISTIC REGRESSION    |  P=0.329N     P=0.278N     P=0.161N     P=0.267N   |  P=0.417N     P=0.417      P=0.494      P=0.628    |
|COCHRAN-ARMITAGE       |  P=0.412N                                          |  P=0.481N                                          |
|FISHER EXACT           |               P=0.213N     P=0.139N     P=0.306N   |               P=0.419      P=0.524      P=0.623    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   3
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/48 (4%)    2/46 (4%)    3/50 (6%)  |  4/48 (8%)    6/25 (24%)   1/21 (5%)    4/48 (8%)  |
|ADJUSTED (b)           |   8.1%        11.8%        10.0%         9.9%      |  14.4%       100.0%       100.0%        14.8%      |
|TERMINAL (d)           |  1/26 (4%)    2/17 (12%)   2/20 (10%)   2/26 (8%)  |  2/20 (10%)   2/2 (100%)   1/1 (100%)   4/27 (15%) |
|FIRST INCIDENCE (DAYS) |   463          749 (T)      749 (T)      638       |   588          466          749 (T)      749 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.588      P=0.603N     P=0.568N     P=0.637N   |  P=0.123N     P=0.063      P=0.666N     P=0.503N   |
|INCIDENTAL TUMOR       |  P=0.560      P=0.660      P=0.599N     P=0.604    |  P=0.156N     P=0.028 *    P=0.737      P=0.563N   |
|LOGISTIC REGRESSION    |  P=0.532      P=0.534N     P=0.538N     P=0.606    |  P=0.246N     P=0.062      P=0.563N     P=0.612N   |
|COCHRAN-ARMITAGE       |  P=0.527                                           |  P=0.308N                                          |
|FISHER EXACT           |               P=0.520N     P=0.540N     P=0.661N   |               P=0.071      P=0.516N     P=0.643N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/48 (6%)    3/46 (7%)    4/50 (8%)  |  5/48 (10%)   6/25 (24%)   1/21 (5%)    4/48 (8%)  |
|ADJUSTED (b)           |   8.1%        13.7%        12.2%        11.8%      |  19.1%       100.0%       100.0%        14.8%      |
|TERMINAL (d)           |  1/26 (4%)    2/17 (12%)   2/20 (10%)   2/26 (8%)  |  3/20 (15%)   2/2 (100%)   1/1 (100%)   4/27 (15%) |
|FIRST INCIDENCE (DAYS) |   463          571          592          522       |   588          466          749 (T)      749 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.490      P=0.581      P=0.608      P=0.528    |  P=0.073N     P=0.075      P=0.641N     P=0.345N   |
|INCIDENTAL TUMOR       |  P=0.433      P=0.478      P=0.564      P=0.360    |  P=0.095N     P=0.035 *    P=0.724N     P=0.397N   |
|LOGISTIC REGRESSION    |  P=0.380      P=0.620      P=0.624      P=0.388    |  P=0.170N     P=0.092      P=0.491N     P=0.455N   |
|COCHRAN-ARMITAGE       |  P=0.423                                           |  P=0.232N                                          |
|FISHER EXACT           |               P=0.641      P=0.621      P=0.500    |               P=0.117      P=0.402N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   4
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    5/36 (14%)   2/27 (7%)    2/48 (4%)  |  0/48 (0%)    0/24 (0%)    1/20 (5%)    0/49 (0%)  |
|ADJUSTED (b)           |   3.7%        70.0%       100.0%         7.7%      |   0.0%         0.0%         2.8%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    2/3 (67%)    1/1 (100%)   2/26 (8%)  |  0/19 (0%)    0/1 (0%)     0/1 (0%)     0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   747          667          698          749 (T)   |   ---          ---          680          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.299N     P=0.011 *    P=0.225      P=0.496    |  P=0.792N       (e)        P=0.550        (e)      |
|INCIDENTAL TUMOR       |  P=0.371N     P=0.061      P=0.354      P=0.511    |  P=0.779        (e)        P=0.362        (e)      |
|LOGISTIC REGRESSION    |  P=0.303N     P=0.012 *    P=0.092      P=0.501    |  P=0.708N       (e)        P=0.289        (e)      |
|COCHRAN-ARMITAGE       |  P=0.419N                                          |  P=0.719N                                          |
|FISHER EXACT           |               P=0.044 *    P=0.280      P=0.485    |                 (e)        P=0.294        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/36 (3%)    2/27 (7%)    0/48 (0%)  |  1/48 (2%)    0/24 (0%)    1/20 (5%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%        33.3%         7.8%         0.0%      |   3.3%         0.0%       100.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    1/3 (33%)    0/1 (0%)     0/26 (0%)  |  0/19 (0%)    0/1 (0%)     1/1 (100%)   0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          749 (T)      702          ---       |   668          ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.434N     P=0.096      P=0.208        (e)      |  P=0.339N     P=0.469N     P=0.570      P=0.493N   |
|INCIDENTAL TUMOR       |  P=0.502N     P=0.096      P=0.329        (e)      |  P=0.376N     P=0.567N     P=0.411      P=0.612N   |
|LOGISTIC REGRESSION    |  P=0.417N     P=0.096      P=0.044 *      (e)      |  P=0.354N     P=0.658N     P=0.456      P=0.503N   |
|COCHRAN-ARMITAGE       |  P=0.484N                                          |  P=0.400N                                          |
|FISHER EXACT           |               P=0.419      P=0.120        (e)      |               P=0.667N     P=0.505      P=0.495N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   5
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    6/36 (17%)   4/27 (15%)   2/48 (4%)  |  1/48 (2%)    0/24 (0%)    2/20 (10%)   0/49 (0%)  |
|ADJUSTED (b)           |   3.7%       100.0%       100.0%         7.7%      |   3.3%         0.0%       100.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    3/3 (100%)   1/1 (100%)   2/26 (8%)  |  0/19 (0%)    0/1 (0%)     1/1 (100%)   0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   747          667          698          749 (T)   |   668          ---          680          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.223N     P=0.001 **   P=0.055      P=0.496    |  P=0.349N     P=0.469N     P=0.321      P=0.493N   |
|INCIDENTAL TUMOR       |  P=0.300N     P=0.009 **   P=0.128      P=0.511    |  P=0.416N     P=0.567N     P=0.127      P=0.612N   |
|LOGISTIC REGRESSION    |  P=0.217N     P=0.003 **   P=0.003 **   P=0.501    |  P=0.335N     P=0.658N     P=0.126      P=0.503N   |
|COCHRAN-ARMITAGE       |  P=0.333N                                          |  P=0.378N                                          |
|FISHER EXACT           |               P=0.020 *    P=0.048 *    P=0.485    |               P=0.667N     P=0.205      P=0.495N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/44 (2%)    1/39 (3%)    0/50 (0%)  |  0/49 (0%)    0/37 (0%)    2/30 (7%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.8%         9.1%         4.5%         0.0%      |   0.0%         0.0%        20.0%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    1/11 (9%)    0/11 (0%)    0/26 (0%)  |  0/20 (0%)    0/11 (0%)    2/10 (20%)   0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      749 (T)      745          ---       |   ---          ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.275N     P=0.559      P=0.642      P=0.500N   |  P=0.548N       (e)        P=0.102        (e)      |
|INCIDENTAL TUMOR       |  P=0.291N     P=0.559      P=0.723      P=0.500N   |  P=0.548N       (e)        P=0.102        (e)      |
|LOGISTIC REGRESSION    |  P=0.270N     P=0.559      P=0.588      P=0.500N   |  P=0.548N       (e)        P=0.102        (e)      |
|COCHRAN-ARMITAGE       |  P=0.313N                                          |  P=0.653N                                          |
|FISHER EXACT           |               P=0.720      P=0.687      P=0.500N   |                 (e)        P=0.141        (e)      |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   6
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/44 (2%)    1/39 (3%)    1/50 (2%)  |  0/49 (0%)    0/37 (0%)    2/30 (7%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.8%         9.1%         4.5%         3.4%      |   0.0%         0.0%        20.0%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    1/11 (9%)    0/11 (0%)    0/26 (0%)  |  0/20 (0%)    0/11 (0%)    2/10 (20%)   0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      749 (T)      745          733       |   ---          ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.578N     P=0.559      P=0.642      P=0.756N   |  P=0.548N       (e)        P=0.102        (e)      |
|INCIDENTAL TUMOR       |  P=0.631N     P=0.559      P=0.723      P=0.732N   |  P=0.548N       (e)        P=0.102        (e)      |
|LOGISTIC REGRESSION    |  P=0.575N     P=0.559      P=0.588      P=0.753N   |  P=0.548N       (e)        P=0.102        (e)      |
|COCHRAN-ARMITAGE       |  P=0.643N                                          |  P=0.653N                                          |
|FISHER EXACT           |               P=0.720      P=0.687      P=0.753N   |                 (e)        P=0.141        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    3/50 (6%)    0/49 (0%)    2/50 (4%)  |  3/49 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%        16.2%         0.0%         5.9%      |   9.7%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/26 (8%)    2/17 (12%)   0/21 (0%)    1/26 (4%)  |  0/20 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      737          ---          581       |   589          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.480N     P=0.318      P=0.286N     P=0.679N   |  P=0.127N     P=0.099N     P=0.095N     P=0.104N   |
|INCIDENTAL TUMOR       |  P=0.498N     P=0.416      P=0.286N     P=0.684N   |  P=0.172N     P=0.160N     P=0.217N     P=0.183N   |
|LOGISTIC REGRESSION    |  P=0.516N     P=0.367      P=0.286N     P=0.682N   |  P=0.136N     P=0.117N     P=0.121N     P=0.124N   |
|COCHRAN-ARMITAGE       |  P=0.549N                                          |  P=0.132N                                          |
|FISHER EXACT           |               P=0.500      P=0.253N     P=0.691N   |               P=0.117N     P=0.117N     P=0.117N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   7
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)  |  0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.8%         0.0%         0.0%         0.0%      |   0.0%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   508          ---          ---          ---       |   ---          749 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.233N     P=0.286N     P=0.266N     P=0.237N   |  P=0.544N     P=0.536        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.277N     P=0.412N     P=0.284N     P=0.353N   |  P=0.544N     P=0.536        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.262N     P=0.256N     P=0.241N     P=0.283N   |  P=0.544N     P=0.536        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.243N                                          |  P=0.575N                                          |
|FISHER EXACT           |               P=0.247N     P=0.253N     P=0.247N   |               P=0.505        (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    3/50 (6%)    0/49 (0%)    2/50 (4%)  |  3/49 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  13.4%        16.2%         0.0%         5.9%      |   9.7%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  3/26 (12%)   2/17 (12%)   0/21 (0%)    1/26 (4%)  |  0/20 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   508          737          ---          581       |   589          749 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.252N     P=0.623      P=0.086N     P=0.324N   |  P=0.087N     P=0.256N     P=0.095N     P=0.104N   |
|INCIDENTAL TUMOR       |  P=0.288N     P=0.636      P=0.093N     P=0.406N   |  P=0.117N     P=0.346N     P=0.217N     P=0.183N   |
|LOGISTIC REGRESSION    |  P=0.289N     P=0.500N     P=0.066N     P=0.350N   |  P=0.096N     P=0.297N     P=0.121N     P=0.124N   |
|COCHRAN-ARMITAGE       |  P=0.302N                                          |  P=0.096N                                          |
|FISHER EXACT           |               P=0.500N     P=0.061N     P=0.339N   |               P=0.301N     P=0.117N     P=0.117N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   8
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    3/50 (6%)    0/49 (0%)    2/50 (4%)  |  3/49 (6%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  13.4%        16.2%         0.0%         5.9%      |   9.7%         4.2%         0.0%         0.0%      |
|TERMINAL (d)           |  3/26 (12%)   2/17 (12%)   0/21 (0%)    1/26 (4%)  |  0/20 (0%)    1/24 (4%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   508          737          ---          581       |   589          749 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.252N     P=0.623      P=0.086N     P=0.324N   |  P=0.087N     P=0.256N     P=0.095N     P=0.104N   |
|INCIDENTAL TUMOR       |  P=0.288N     P=0.636      P=0.093N     P=0.406N   |  P=0.117N     P=0.346N     P=0.217N     P=0.183N   |
|LOGISTIC REGRESSION    |  P=0.289N     P=0.500N     P=0.066N     P=0.350N   |  P=0.096N     P=0.297N     P=0.121N     P=0.124N   |
|COCHRAN-ARMITAGE       |  P=0.302N                                          |  P=0.096N                                          |
|FISHER EXACT           |               P=0.500N     P=0.061N     P=0.339N   |               P=0.301N     P=0.117N     P=0.117N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    2/49 (4%)    1/50 (2%)    0/50 (0%)  |  2/49 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  15.4%        10.0%         2.9%         0.0%      |  10.0%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  4/26 (15%)   1/17 (6%)    0/21 (0%)    0/26 (0%)  |  2/20 (10%)   0/24 (0%)    1/29 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      728          667          ---       |   749 (T)      ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.044N*    P=0.528N     P=0.232N     P=0.061N   |  P=0.225N     P=0.198N     P=0.370N     P=0.174N   |
|INCIDENTAL TUMOR       |  P=0.047N*    P=0.443N     P=0.205N     P=0.061N   |  P=0.225N     P=0.198N     P=0.370N     P=0.174N   |
|LOGISTIC REGRESSION    |  P=0.045N*    P=0.455N     P=0.200N     P=0.061N   |  P=0.225N     P=0.198N     P=0.370N     P=0.174N   |
|COCHRAN-ARMITAGE       |  P=0.052N                                          |  P=0.268N                                          |
|FISHER EXACT           |               P=0.349N     P=0.181N     P=0.059N   |               P=0.242N     P=0.492N     P=0.242N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE   9
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         8.4%         0.0%         0.0%      |   0.0%         0.0%         6.9%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    1/17 (6%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    0/24 (0%)    2/29 (7%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          667          ---          ---       |   ---          ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.354N     P=0.205        (e)          (e)      |  P=0.655N       (e)        P=0.323        (e)      |
|INCIDENTAL TUMOR       |  P=0.366N     P=0.268        (e)          (e)      |  P=0.655N       (e)        P=0.323        (e)      |
|LOGISTIC REGRESSION    |  P=0.359N     P=0.234        (e)          (e)      |  P=0.655N       (e)        P=0.323        (e)      |
|COCHRAN-ARMITAGE       |  P=0.367N                                          |  P=0.695N                                          |
|FISHER EXACT           |               P=0.242        (e)          (e)      |                 (e)        P=0.253        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    4/49 (8%)    1/50 (2%)    0/50 (0%)  |  2/49 (4%)    0/50 (0%)    3/50 (6%)    0/50 (0%)  |
|ADJUSTED (b)           |  15.4%        17.8%         2.9%         0.0%      |  10.0%         0.0%        10.3%         0.0%      |
|TERMINAL (d)           |  4/26 (15%)   2/17 (12%)   0/21 (0%)    0/26 (0%)  |  2/20 (10%)   0/24 (0%)    3/29 (10%)   0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      667          667          ---       |   749 (T)      ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.024N*    P=0.453      P=0.232N     P=0.061N   |  P=0.234N     P=0.198N     P=0.669      P=0.174N   |
|INCIDENTAL TUMOR       |  P=0.026N*    P=0.576      P=0.205N     P=0.061N   |  P=0.234N     P=0.198N     P=0.669      P=0.174N   |
|LOGISTIC REGRESSION    |  P=0.024N*    P=0.589      P=0.200N     P=0.061N   |  P=0.234N     P=0.198N     P=0.669      P=0.174N   |
|COCHRAN-ARMITAGE       |  P=0.029N*                                         |  P=0.294N                                          |
|FISHER EXACT           |               P=0.631      P=0.181N     P=0.059N   |               P=0.242N     P=0.510      P=0.242N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  10
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.0%         6.8%         2.1%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  1/20 (5%)    1/24 (4%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   749 (T)      666          536          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.210N     P=0.552      P=0.720N     P=0.440N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.237N     P=0.524      P=0.693N     P=0.440N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.235N     P=0.528      P=0.756      P=0.440N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.231N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500      P=0.753N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    3/50 (6%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   5.0%        10.9%         2.1%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  1/20 (5%)    2/24 (8%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   749 (T)      666          536          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.144N     P=0.363      P=0.720N     P=0.440N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.163N     P=0.341      P=0.693N     P=0.440N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.167N     P=0.341      P=0.756      P=0.440N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.169N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.309      P=0.753N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  11
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  | 16/50 (32%)  11/50 (22%)  13/50 (26%)  17/50 (34%) |
|ADJUSTED (b)           |   3.8%         0.0%         0.0%         3.8%      |  51.0%        40.9%        39.8%        44.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    0/21 (0%)    1/26 (4%)  |  7/20 (35%)   9/24 (38%)  10/29 (34%)   8/27 (30%) |
|FIRST INCIDENCE (DAYS) |   749 (T)      ---          ---          749 (T)   |   543          601          563          476       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.441      P=0.100N     P=0.106N     P=0.437N   |
|INCIDENTAL TUMOR       |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.294      P=0.159N     P=0.285N     P=0.488    |
|LOGISTIC REGRESSION    |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.280      P=0.153N     P=0.262N     P=0.489    |
|COCHRAN-ARMITAGE       |  P=0.536                                           |  P=0.250                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.753N   |               P=0.184N     P=0.330N     P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  | 16/50 (32%)  12/50 (24%)  13/50 (26%)  17/50 (34%) |
|ADJUSTED (b)           |   3.8%         0.0%         0.0%         3.8%      |  51.0%        44.8%        39.8%        44.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    0/21 (0%)    1/26 (4%)  |  7/20 (35%)  10/24 (42%)  10/29 (34%)   8/27 (30%) |
|FIRST INCIDENCE (DAYS) |   749 (T)      ---          ---          749 (T)   |   543          601          563          476       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.485      P=0.141N     P=0.106N     P=0.437N   |
|INCIDENTAL TUMOR       |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.336      P=0.215N     P=0.285N     P=0.488    |
|LOGISTIC REGRESSION    |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.319      P=0.212N     P=0.262N     P=0.489    |
|COCHRAN-ARMITAGE       |  P=0.536                                           |  P=0.286                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.753N   |               P=0.252N     P=0.330N     P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  12
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  | 17/50 (34%)  13/50 (26%)  14/50 (28%)  17/50 (34%) |
|ADJUSTED (b)           |   3.8%         0.0%         0.0%         3.8%      |  54.7%        46.3%        41.1%        44.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    0/21 (0%)    1/26 (4%)  |  8/20 (40%)  10/24 (42%)  10/29 (34%)   8/27 (30%) |
|FIRST INCIDENCE (DAYS) |   749 (T)      ---          ---          749 (T)   |   543          601          536          476       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.515N     P=0.141N     P=0.106N     P=0.355N   |
|INCIDENTAL TUMOR       |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.426      P=0.219N     P=0.268N     P=0.582N   |
|LOGISTIC REGRESSION    |  P=0.572      P=0.585N     P=0.543N     P=0.762    |  P=0.414      P=0.214N     P=0.277N     P=0.580    |
|COCHRAN-ARMITAGE       |  P=0.536                                           |  P=0.380                                           |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.753N   |               P=0.257N     P=0.333N     P=0.583N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/42 (5%)    1/32 (3%)    0/27 (0%)    0/41 (0%)  |  0/40 (0%)    0/22 (0%)    0/18 (0%)    0/43 (0%)  |
|ADJUSTED (b)           |   6.8%       100.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/23 (4%)    1/1 (100%)   0/0          0/19 (0%)  |  0/17 (0%)    0/2 (0%)     0/0          0/25 (0%)  |
|FIRST INCIDENCE (DAYS) |   585          749 (T)      ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.149N     P=0.579      P=0.485N     P=0.244N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.151N     P=0.535      P=0.527N     P=0.261N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.158N     P=0.628N     P=0.336N     P=0.258N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.165N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.602N     P=0.367N     P=0.253N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  13
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/47 (53%)  25/43 (58%)  25/40 (63%)  25/47 (53%) | 28/48 (58%)  26/44 (59%)  32/42 (76%)  32/49 (65%) |
|ADJUSTED (b)           |  67.4%        94.2%        89.2%        69.9%      |  83.7%        84.9%        93.4%        83.5%      |
|TERMINAL (d)           | 14/25 (56%)   9/10 (90%)  10/12 (83%)  15/25 (60%) | 15/20 (75%)  15/19 (79%)  20/22 (91%)  21/27 (78%) |
|FIRST INCIDENCE (DAYS) |   438          485          389          612       |   507          519          457          505       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.181N     P=0.050 *    P=0.085      P=0.525N   |  P=0.375N     P=0.385N     P=0.539      P=0.396N   |
|INCIDENTAL TUMOR       |  P=0.395N     P=0.197      P=0.177      P=0.558    |  P=0.417      P=0.556      P=0.083      P=0.415    |
|LOGISTIC REGRESSION    |  P=0.378N     P=0.375      P=0.149      P=0.547N   |  P=0.384      P=0.576      P=0.068      P=0.401    |
|COCHRAN-ARMITAGE       |  P=0.447N                                          |  P=0.285                                           |
|FISHER EXACT           |               P=0.398      P=0.256      P=0.582N   |               P=0.555      P=0.058      P=0.309    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/47 (2%)    3/43 (7%)    2/40 (5%)    2/47 (4%)  |  2/48 (4%)    3/44 (7%)    2/42 (5%)    3/49 (6%)  |
|ADJUSTED (b)           |   2.8%         9.6%        16.7%         8.0%      |   7.4%        10.0%         4.7%         7.5%      |
|TERMINAL (d)           |  0/25 (0%)    0/10 (0%)    2/12 (17%)   2/25 (8%)  |  1/20 (5%)    1/19 (5%)    0/22 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   655          553          749 (T)      749 (T)   |   589          508          549          578       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.550N     P=0.297      P=0.335      P=0.509    |  P=0.544      P=0.511      P=0.671N     P=0.555    |
|INCIDENTAL TUMOR       |  P=0.604N     P=0.554      P=0.379      P=0.521    |  P=0.478      P=0.475      P=0.619      P=0.457    |
|LOGISTIC REGRESSION    |  P=0.608N     P=0.277      P=0.390      P=0.517    |  P=0.462      P=0.461      P=0.633      P=0.470    |
|COCHRAN-ARMITAGE       |  P=0.603                                           |  P=0.516                                           |
|FISHER EXACT           |               P=0.275      P=0.439      P=0.500    |               P=0.458      P=0.640      P=0.510    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  14
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 26/47 (55%)  28/43 (65%)  27/40 (68%)  27/47 (57%) | 30/48 (63%)  29/44 (66%)  34/42 (81%)  35/49 (71%) |
|ADJUSTED (b)           |  68.3%        94.7%       100.0%        75.9%      |  87.3%        89.3%        93.7%        84.7%      |
|TERMINAL (d)           | 14/25 (56%)   9/10 (90%)  12/12 (100%) 17/25 (68%) | 16/20 (80%)  16/19 (84%)  20/22 (91%)  21/27 (78%) |
|FIRST INCIDENCE (DAYS) |   438          485          389          612       |   507          508          457          505       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.170N     P=0.029 *    P=0.049 *    P=0.546    |  P=0.404N     P=0.452N     P=0.546      P=0.446N   |
|INCIDENTAL TUMOR       |  P=0.387N     P=0.151      P=0.099      P=0.483    |  P=0.350      P=0.454      P=0.067      P=0.310    |
|LOGISTIC REGRESSION    |  P=0.372N     P=0.218      P=0.086      P=0.544    |  P=0.314      P=0.458      P=0.051      P=0.302    |
|COCHRAN-ARMITAGE       |  P=0.453N                                          |  P=0.239                                           |
|FISHER EXACT           |               P=0.232      P=0.174      P=0.500    |               P=0.451      P=0.044 *    P=0.236    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    3/50 (6%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         2.3%        12.1%         9.9%      |   0.0%         0.0%         3.4%         3.4%      |
|TERMINAL (d)           |  0/26 (0%)    0/17 (0%)    2/21 (10%)   2/26 (8%)  |  0/20 (0%)    0/24 (0%)    1/29 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          586          667          638       |   ---          ---          749 (T)      716       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.145      P=0.529      P=0.100      P=0.130    |  P=0.336        (e)        P=0.574      P=0.546    |
|INCIDENTAL TUMOR       |  P=0.138      P=0.500      P=0.118      P=0.129    |  P=0.284        (e)        P=0.574      P=0.412    |
|LOGISTIC REGRESSION    |  P=0.113      P=0.461      P=0.111      P=0.128    |  P=0.316        (e)        P=0.574      P=0.517    |
|COCHRAN-ARMITAGE       |  P=0.107                                           |  P=0.303                                           |
|FISHER EXACT           |               P=0.500      P=0.121      P=0.121    |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  15
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%         0.0%         0.0%         0.0%      |   0.0%         0.0%         6.1%         0.0%      |
|TERMINAL (d)           |  2/26 (8%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    0/24 (0%)    1/29 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      ---          ---          ---       |   ---          ---          680          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.224N     P=0.335N     P=0.286N     P=0.238N   |  P=0.678N       (e)        P=0.310        (e)      |
|INCIDENTAL TUMOR       |  P=0.224N     P=0.335N     P=0.286N     P=0.238N   |  P=0.716N       (e)        P=0.214        (e)      |
|LOGISTIC REGRESSION    |  P=0.224N     P=0.335N     P=0.286N     P=0.238N   |  P=0.688N       (e)        P=0.256        (e)      |
|COCHRAN-ARMITAGE       |  P=0.242N                                          |  P=0.697N                                          |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.247N   |                 (e)        P=0.247        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    3/50 (6%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)  |
|ADJUSTED (b)           |   7.7%         2.3%        12.1%         9.9%      |   0.0%         0.0%         9.5%         3.4%      |
|TERMINAL (d)           |  2/26 (8%)    0/17 (0%)    2/21 (10%)   2/26 (8%)  |  0/20 (0%)    0/24 (0%)    2/29 (7%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      586          667          638       |   ---          ---          680          716       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.385      P=0.581N     P=0.425      P=0.512    |  P=0.422        (e)        P=0.187      P=0.546    |
|INCIDENTAL TUMOR       |  P=0.379      P=0.598N     P=0.458      P=0.511    |  P=0.353        (e)        P=0.128      P=0.412    |
|LOGISTIC REGRESSION    |  P=0.342      P=0.498N     P=0.465      P=0.529    |  P=0.399        (e)        P=0.144      P=0.517    |
|COCHRAN-ARMITAGE       |  P=0.318                                           |  P=0.381                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500    |                 (e)        P=0.121      P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  16
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    0/50 (0%)    3/50 (6%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%         2.6%         0.0%         7.4%      |   0.0%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  2/26 (8%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    0/24 (0%)    1/29 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      667          ---          581       |   ---          ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.306      P=0.585N     P=0.286N     P=0.537    |  P=0.761N       (e)        P=0.574        (e)      |
|INCIDENTAL TUMOR       |  P=0.273      P=0.506N     P=0.286N     P=0.545    |  P=0.761N       (e)        P=0.574        (e)      |
|LOGISTIC REGRESSION    |  P=0.248      P=0.506N     P=0.286N     P=0.486    |  P=0.761N       (e)        P=0.574        (e)      |
|COCHRAN-ARMITAGE       |  P=0.256                                           |  P=0.786N                                          |
|FISHER EXACT           |               P=0.500N     P=0.247N     P=0.500    |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    0/50 (0%)    3/50 (6%)  |  0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%         2.6%         0.0%         7.4%      |   0.0%         3.3%         3.4%         0.0%      |
|TERMINAL (d)           |  2/26 (8%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    0/24 (0%)    1/29 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      667          ---          581       |   ---          715          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.306      P=0.585N     P=0.286N     P=0.537    |  P=0.501N     P=0.553      P=0.574        (e)      |
|INCIDENTAL TUMOR       |  P=0.273      P=0.506N     P=0.286N     P=0.545    |  P=0.556N     P=0.469      P=0.574        (e)      |
|LOGISTIC REGRESSION    |  P=0.248      P=0.506N     P=0.286N     P=0.486    |  P=0.521N     P=0.512      P=0.574        (e)      |
|COCHRAN-ARMITAGE       |  P=0.256                                           |  P=0.536N                                          |
|FISHER EXACT           |               P=0.500N     P=0.247N     P=0.500    |               P=0.500      P=0.500        (e)      |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  17
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 31/50 (62%)  38/47 (81%)  36/50 (72%)  41/50 (82%) |                                                    |
|ADJUSTED (b)           |  83.2%        97.0%        97.1%        93.0%      |                                                    |
|TERMINAL (d)           | 20/26 (77%)  13/14 (93%)  20/21 (95%)  23/26 (88%) |                                                    |
|FIRST INCIDENCE (DAYS) |   508          560          529          473       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.465      P=0.004 **   P=0.063      P=0.096    |                                                    |
|INCIDENTAL TUMOR       |  P=0.132      P=0.057      P=0.115      P=0.034 *  |                                                    |
|LOGISTIC REGRESSION    |  P=0.137      P=0.033 *    P=0.150      P=0.041 *  |                                                    |
|COCHRAN-ARMITAGE       |  P=0.069                                           |                                                    |
|FISHER EXACT           |               P=0.033 *    P=0.198      P=0.022 *  |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/48 (4%)    9/49 (18%)   7/46 (15%)   6/48 (13%) |  4/48 (8%)    2/26 (8%)    0/18 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   7.7%        35.5%        22.8%        17.2%      |  15.2%        27.7%         0.0%        11.1%      |
|TERMINAL (d)           |  2/26 (8%)    2/17 (12%)   2/20 (10%)   2/26 (8%)  |  2/20 (10%)   1/4 (25%)    0/0          3/27 (11%) |
|FIRST INCIDENCE (DAYS) |   749 (T)      702          571          577       |   641          720          ---          749 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.543      P=0.009 **   P=0.060      P=0.157    |  P=0.280N     P=0.653N     P=0.227N     P=0.385N   |
|INCIDENTAL TUMOR       |  P=0.409      P=0.086      P=0.068      P=0.164    |  P=0.308N     P=0.602      P=0.371N     P=0.425N   |
|LOGISTIC REGRESSION    |  P=0.450      P=0.078      P=0.071      P=0.139    |  P=0.337N     P=0.618      P=0.346N     P=0.441N   |
|COCHRAN-ARMITAGE       |  P=0.428                                           |  P=0.444N                                          |
|FISHER EXACT           |               P=0.028 *    P=0.070      P=0.134    |               P=0.648N     P=0.270N     P=0.477N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  18
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/48 (0%)    1/49 (2%)    2/46 (4%)    0/48 (0%)  |  1/48 (2%)    1/26 (4%)    0/18 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         5.0%         6.7%         0.0%      |   5.0%        25.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/17 (0%)    0/20 (0%)    0/26 (0%)  |  1/20 (5%)    1/4 (25%)    0/0          0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          737          687          ---       |   749 (T)      749 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.490N     P=0.433      P=0.225        (e)      |  P=0.176N     P=0.373        (e)        P=0.440N   |
|INCIDENTAL TUMOR       |  P=0.594N     P=0.678      P=0.354        (e)      |  P=0.176N     P=0.373        (e)        P=0.440N   |
|LOGISTIC REGRESSION    |  P=0.506N     P=0.479      P=0.228        (e)      |  P=0.176N     P=0.373        (e)        P=0.440N   |
|COCHRAN-ARMITAGE       |  P=0.517N                                          |  P=0.265N                                          |
|FISHER EXACT           |               P=0.505      P=0.237        (e)      |               P=0.582      P=0.727N     P=0.490N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/48 (4%)   10/49 (20%)   9/46 (20%)   6/48 (13%) |  5/48 (10%)   3/26 (12%)   0/18 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   7.7%        38.7%        28.0%        17.2%      |  19.9%        51.8%         0.0%        11.1%      |
|TERMINAL (d)           |  2/26 (8%)    2/17 (12%)   2/20 (10%)   2/26 (8%)  |  3/20 (15%)   2/4 (50%)    0/0          3/27 (11%) |
|FIRST INCIDENCE (DAYS) |   749 (T)      702          571          577       |   641          720          ---          749 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.520N     P=0.005 **   P=0.021 *    P=0.157    |  P=0.114N     P=0.471      P=0.227N     P=0.241N   |
|INCIDENTAL TUMOR       |  P=0.454      P=0.063      P=0.032 *    P=0.164    |  P=0.130N     P=0.363      P=0.371N     P=0.272N   |
|LOGISTIC REGRESSION    |  P=0.521      P=0.052      P=0.023 *    P=0.139    |  P=0.163N     P=0.442      P=0.310N     P=0.292N   |
|COCHRAN-ARMITAGE       |  P=0.496                                           |  P=0.261N                                          |
|FISHER EXACT           |               P=0.015 *    P=0.021 *    P=0.134    |               P=0.583      P=0.192N     P=0.335N   |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  19
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/48 (0%)    2/49 (4%)    1/46 (2%)    1/48 (2%)  |  0/48 (0%)    1/26 (4%)    0/18 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%        11.8%         5.0%         3.8%      |   0.0%        25.0%         0.0%         3.7%      |
|TERMINAL (d)           |  0/26 (0%)    2/17 (12%)   1/20 (5%)    1/26 (4%)  |  0/20 (0%)    1/4 (25%)    0/0          1/27 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          749 (T)      749 (T)      749 (T)   |   ---          749 (T)      ---          749 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.655N     P=0.150      P=0.448      P=0.500    |  P=0.673      P=0.186        (e)        P=0.560    |
|INCIDENTAL TUMOR       |  P=0.655N     P=0.150      P=0.448      P=0.500    |  P=0.673      P=0.186        (e)        P=0.560    |
|LOGISTIC REGRESSION    |  P=0.655N     P=0.150      P=0.448      P=0.500    |  P=0.673      P=0.186        (e)        P=0.560    |
|COCHRAN-ARMITAGE       |  P=0.616                                           |  P=0.537                                           |
|FISHER EXACT           |               P=0.253      P=0.489      P=0.500    |               P=0.351        (e)        P=0.510    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  5/50 (10%)   7/50 (14%)   5/50 (10%)   8/50 (16%) |
|ADJUSTED (b)           |                                                    |  19.2%        23.5%        13.8%        21.5%      |
|TERMINAL (d)           |                                                    |  2/20 (10%)   4/24 (17%)   1/29 (3%)    3/27 (11%) |
|FIRST INCIDENCE (DAYS) |                                                    |   576          568          465          522       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.378      P=0.482      P=0.472N     P=0.398    |
|INCIDENTAL TUMOR       |                                                    |  P=0.248      P=0.346      P=0.513      P=0.251    |
|LOGISTIC REGRESSION    |                                                    |  P=0.270      P=0.395      P=0.630      P=0.258    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.278                                           |
|FISHER EXACT           |                                                    |               P=0.380      P=0.630N     P=0.277    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  20
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   6.6%         2.0%         0.0%         2.3%      |   0.0%         2.7%         0.0%         5.6%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   666          485          ---          625       |   ---          612          ---          633       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.478N     P=0.537N     P=0.263N     P=0.479N   |  P=0.172      P=0.500        (e)        P=0.270    |
|INCIDENTAL TUMOR       |  P=0.540N     P=0.578N     P=0.217N     P=0.456N   |  P=0.132      P=0.419        (e)        P=0.174    |
|LOGISTIC REGRESSION    |  P=0.549N     P=0.530N     P=0.243N     P=0.512N   |  P=0.136      P=0.507        (e)        P=0.226    |
|COCHRAN-ARMITAGE       |  P=0.500N                                          |  P=0.151                                           |
|FISHER EXACT           |               P=0.500N     P=0.247N     P=0.500N   |               P=0.500        (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 29/50 (58%)  35/50 (70%)  30/50 (60%)  28/50 (56%) | 24/50 (48%)  24/50 (48%)  21/50 (42%)  33/50 (66%) |
|ADJUSTED (b)           |  71.3%        86.0%        73.4%        72.2%      |  67.5%        61.3%        54.3%        79.8%      |
|TERMINAL (d)           | 15/26 (58%)  12/17 (71%)  11/21 (52%)  16/26 (62%) | 10/20 (50%)  10/24 (42%)  12/29 (41%)  19/27 (70%) |
|FIRST INCIDENCE (DAYS) |   508          553          389          577       |   487          438          563          522       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.134N     P=0.054      P=0.311      P=0.440N   |  P=0.157      P=0.368N     P=0.099N     P=0.330    |
|INCIDENTAL TUMOR       |  P=0.193N     P=0.224      P=0.568      P=0.431N   |  P=0.020 *    P=0.543      P=0.428N     P=0.059    |
|LOGISTIC REGRESSION    |  P=0.193N     P=0.261      P=0.493      P=0.453N   |  P=0.026 *    P=0.578N     P=0.306N     P=0.065    |
|COCHRAN-ARMITAGE       |  P=0.242N                                          |  P=0.023 *                                         |
|FISHER EXACT           |               P=0.149      P=0.500      P=0.500N   |               P=0.579N     P=0.344N     P=0.053    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  21
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   6.9%         0.0%         0.0%         0.0%      |   0.0%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    0/24 (0%)    1/29 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   699          ---          ---          ---       |   ---          ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.233N     P=0.298N     P=0.279N     P=0.240N   |  P=0.761N       (e)        P=0.574        (e)      |
|INCIDENTAL TUMOR       |  P=0.242N     P=0.189N     P=0.217N     P=0.211N   |  P=0.761N       (e)        P=0.574        (e)      |
|LOGISTIC REGRESSION    |  P=0.233N     P=0.242N     P=0.248N     P=0.224N   |  P=0.761N       (e)        P=0.574        (e)      |
|COCHRAN-ARMITAGE       |  P=0.242N                                          |  P=0.786N                                          |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.247N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   6.9%         0.0%         0.0%         0.0%      |   0.0%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/17 (0%)    0/21 (0%)    0/26 (0%)  |  0/20 (0%)    0/24 (0%)    1/29 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   699          ---          ---          ---       |   ---          ---          749 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.233N     P=0.298N     P=0.279N     P=0.240N   |  P=0.761N       (e)        P=0.574        (e)      |
|INCIDENTAL TUMOR       |  P=0.242N     P=0.189N     P=0.217N     P=0.211N   |  P=0.761N       (e)        P=0.574        (e)      |
|LOGISTIC REGRESSION    |  P=0.233N     P=0.242N     P=0.248N     P=0.224N   |  P=0.761N       (e)        P=0.574        (e)      |
|COCHRAN-ARMITAGE       |  P=0.242N                                          |  P=0.786N                                          |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.247N   |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  22
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    3/50 (6%)    3/50 (6%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.8%        12.8%        11.5%         2.2%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    1/17 (6%)    2/21 (10%)   0/26 (0%)  |  0/20 (0%)    0/24 (0%)    0/29 (0%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   749 (T)      690          536          606       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.360N     P=0.216      P=0.252      P=0.742N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.421N     P=0.368      P=0.250      P=0.747N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.407N     P=0.288      P=0.300      P=0.756    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.414N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.309      P=0.309      P=0.753N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 46/50 (92%)  45/50 (90%)  47/50 (94%)  48/50 (96%) | 41/50 (82%)  35/50 (70%)  40/50 (80%)  43/50 (86%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%        98.0%      |  97.5%        84.8%        86.8%        97.6%      |
|TERMINAL (d)           | 26/26 (100%) 17/17 (100%) 21/21 (100%) 25/26 (96%) | 19/20 (95%)  18/24 (75%)  23/29 (79%)  26/27 (96%) |
|FIRST INCIDENCE (DAYS) |   438          485          389          473       |   465          466          457          476       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.319N     P=0.124      P=0.197      P=0.536    |  P=0.470N     P=0.062N     P=0.063N     P=0.208N   |
|INCIDENTAL TUMOR       |  P=0.250      P=0.586N     P=0.406      P=0.354    |  P=0.151      P=0.109N     P=0.433N     P=0.548    |
|LOGISTIC REGRESSION    |  P=0.272      P=0.405N     P=0.478      P=0.412    |  P=0.165      P=0.105N     P=0.455N     P=0.474    |
|COCHRAN-ARMITAGE       |  P=0.200                                           |  P=0.128                                           |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.339    |               P=0.121N     P=0.500N     P=0.393    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  23
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |   CONTROL      .075 MG/     0.25 MG/     0.75 MG/  |
|                       |                M3           M3           M3        |                M3           M3           M3        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/50 (66%)  42/50 (84%)  37/50 (74%)  37/50 (74%) | 28/50 (56%)  32/50 (64%)  29/50 (58%)  37/50 (74%) |
|ADJUSTED (b)           |  79.6%        95.2%        81.5%        81.5%      |  75.5%        72.2%        69.9%        83.8%      |
|TERMINAL (d)           | 18/26 (69%)  15/17 (88%)  13/21 (62%)  18/26 (69%) | 12/20 (60%)  12/24 (50%)  17/29 (59%)  20/27 (74%) |
|FIRST INCIDENCE (DAYS) |   508          485          389          473       |   487          438          536          522       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.282N     P=0.014 *    P=0.165      P=0.400    |  P=0.309      P=0.554      P=0.212N     P=0.379    |
|INCIDENTAL TUMOR       |  P=0.553      P=0.044 *    P=0.308      P=0.282    |  P=0.039 *    P=0.226      P=0.451      P=0.046 *  |
|LOGISTIC REGRESSION    |  P=0.555      P=0.035 *    P=0.254      P=0.264    |  P=0.059      P=0.272      P=0.537      P=0.057    |
|COCHRAN-ARMITAGE       |  P=0.532                                           |  P=0.050 *                                         |
|FISHER EXACT           |               P=0.032 *    P=0.257      P=0.257    |               P=0.270      P=0.500      P=0.046 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 49/50 (98%)  50/50 (100%) 50/50 (100%)| 47/50 (94%)  47/50 (94%)  47/50 (94%)  50/50 (100%)|
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      | 100.0%        94.0%        94.0%       100.0%      |
|TERMINAL (d)           | 26/26 (100%) 17/17 (100%) 21/21 (100%) 26/26 (100%)| 20/20 (100%) 21/24 (88%)  26/29 (90%)  27/27 (100%)|
|FIRST INCIDENCE (DAYS) |   438          485          389          473       |   465          438          370          476       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.215N     P=0.151      P=0.254      P=0.454N   |  P=0.339N     P=0.254N     P=0.078N     P=0.245N   |
|INCIDENTAL TUMOR       |  P=0.706      P=0.282N       (e)          (e)      |  P=0.068      P=0.631N     P=0.646N     P=0.171    |
|LOGISTIC REGRESSION    |  P=0.797      P=0.282N       (e)          (e)      |  P=0.073      P=0.653      P=0.648      P=0.133    |
|COCHRAN-ARMITAGE       |  P=0.576                                           |  P=0.082                                           |
|FISHER EXACT           |               P=0.500N     P=1.000N     P=1.000N   |               P=0.661N     P=0.661N     P=0.121    |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05096 TEST: 01                                                 PAGE  24
                   STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
 
                                                 TERMINAL SACRIFICE AT 107 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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