TDMS Study 05096-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest 0-CHLOROBENZALMALONONITRILE (CS-2) DATE: 09/13/94
EXPERIMENT: 05096 TEST: 01 TIME: 02:13:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55118
PATHOLOGIST: R. MILLER CAS: 2698-41-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest 0-CHLOROBENZALMALONONITRILE (CS-2) DATE: 09/13/94
EXPERIMENT: 05096 TEST: 01 TIME: 02:13:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55118
PATHOLOGIST: R. MILLER CAS: 2698-41-1
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest 0-CHLOROBENZALMALONONITRILE (CS-2) DATE: 09/13/94
EXPERIMENT: 05096 TEST: 01 TIME: 02:13:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55118
PATHOLOGIST: R. MILLER CAS: 2698-41-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 0-CHLOROBENZALMALONONITRILE (CS-2)
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Islets, Pancreatic Adenoma
Carcinoma
Carcinoma or Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Malignant Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Malignant Tumors
====================================================================================================
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/48 (2%) 1/49 (2%) | 2/49 (4%) 0/25 (0%) 2/23 (9%) 0/48 (0%) |
|ADJUSTED (b) | 3.8% 0.0% 4.8% 3.8% | 6.3% 0.0% 35.4% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 1/21 (5%) 1/26 (4%) | 0/20 (0%) 0/2 (0%) 1/3 (33%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- 749 (T) 749 (T) | 588 --- 709 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.588 P=0.585N P=0.714 P=0.762 | P=0.217N P=0.219N P=0.614 P=0.216N |
|INCIDENTAL TUMOR | P=0.588 P=0.585N P=0.714 P=0.762 | P=0.287N P=0.314N P=0.402 P=0.326N |
|LOGISTIC REGRESSION | P=0.588 P=0.585N P=0.714 P=0.762 | P=0.217N P=0.375N P=0.345 P=0.257N |
|COCHRAN-ARMITAGE | P=0.539 | P=0.241N |
|FISHER EXACT | P=0.500N P=0.742 P=0.747 | P=0.435N P=0.382 P=0.253N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/42 (43%) 17/46 (37%) 13/47 (28%) 13/38 (34%) | 5/37 (14%) 3/21 (14%) 3/18 (17%) 6/44 (14%) |
|ADJUSTED (b) | 60.6% 67.3% 43.3% 39.5% | 19.4% 8.5% 52.8% 20.1% |
|TERMINAL (d) | 12/23 (52%) 8/15 (53%) 6/21 (29%) 6/23 (26%) | 2/19 (11%) 0/2 (0%) 1/2 (50%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | 585 586 599 473 | 465 602 639 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.092N P=0.257 P=0.296N P=0.193N | P=0.512N P=0.525N P=0.650N P=0.586N |
|INCIDENTAL TUMOR | P=0.259N P=0.394N P=0.097N P=0.225N | P=0.555 P=0.629N P=0.523 P=0.518 |
|LOGISTIC REGRESSION | P=0.218N P=0.483N P=0.124N P=0.241N | P=0.501N P=0.639 P=0.494 P=0.628 |
|COCHRAN-ARMITAGE | P=0.308N | P=0.559N |
|FISHER EXACT | P=0.364N P=0.100N P=0.287N | P=0.612 P=0.524 P=0.623 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/42 (10%) 0/46 (0%) 4/47 (9%) 3/38 (8%) | 0/37 (0%) 1/21 (5%) 0/18 (0%) 0/44 (0%) |
|ADJUSTED (b) | 17.4% 0.0% 14.3% 10.9% | 0.0% 3.6% 0.0% 0.0% |
|TERMINAL (d) | 4/23 (17%) 0/15 (0%) 2/21 (10%) 2/23 (9%) | 0/19 (0%) 0/2 (0%) 0/2 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- 452 638 | --- 720 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.554 P=0.125N P=0.602 P=0.490N | P=0.565N P=0.548 (e) (e) |
|INCIDENTAL TUMOR | P=0.489 P=0.125N P=0.618N P=0.543N | P=0.628N P=0.479 (e) (e) |
|LOGISTIC REGRESSION | P=0.426 P=0.125N P=0.596N P=0.520N | P=0.468N P=0.303 (e) (e) |
|COCHRAN-ARMITAGE | P=0.403 | P=0.499N |
|FISHER EXACT | P=0.048N* P=0.578N P=0.557N | P=0.362 (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/42 (48%) 17/46 (37%) 16/47 (34%) 15/38 (39%) | 5/37 (14%) 4/21 (19%) 3/18 (17%) 6/44 (14%) |
|ADJUSTED (b) | 65.0% 67.3% 49.8% 44.5% | 19.4% 11.8% 52.8% 20.1% |
|TERMINAL (d) | 13/23 (57%) 8/15 (53%) 7/21 (33%) 7/23 (30%) | 2/19 (11%) 0/2 (0%) 1/2 (50%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | 569 586 452 473 | 465 602 639 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.126N P=0.392 P=0.385N P=0.196N | P=0.450N P=0.636 P=0.650N P=0.586N |
|INCIDENTAL TUMOR | P=0.367N P=0.242N P=0.136N P=0.271N | P=0.555N P=0.523 P=0.523 P=0.518 |
|LOGISTIC REGRESSION | P=0.329N P=0.278N P=0.161N P=0.267N | P=0.417N P=0.417 P=0.494 P=0.628 |
|COCHRAN-ARMITAGE | P=0.412N | P=0.481N |
|FISHER EXACT | P=0.213N P=0.139N P=0.306N | P=0.419 P=0.524 P=0.623 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/48 (4%) 2/46 (4%) 3/50 (6%) | 4/48 (8%) 6/25 (24%) 1/21 (5%) 4/48 (8%) |
|ADJUSTED (b) | 8.1% 11.8% 10.0% 9.9% | 14.4% 100.0% 100.0% 14.8% |
|TERMINAL (d) | 1/26 (4%) 2/17 (12%) 2/20 (10%) 2/26 (8%) | 2/20 (10%) 2/2 (100%) 1/1 (100%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | 463 749 (T) 749 (T) 638 | 588 466 749 (T) 749 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.588 P=0.603N P=0.568N P=0.637N | P=0.123N P=0.063 P=0.666N P=0.503N |
|INCIDENTAL TUMOR | P=0.560 P=0.660 P=0.599N P=0.604 | P=0.156N P=0.028 * P=0.737 P=0.563N |
|LOGISTIC REGRESSION | P=0.532 P=0.534N P=0.538N P=0.606 | P=0.246N P=0.062 P=0.563N P=0.612N |
|COCHRAN-ARMITAGE | P=0.527 | P=0.308N |
|FISHER EXACT | P=0.520N P=0.540N P=0.661N | P=0.071 P=0.516N P=0.643N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/48 (6%) 3/46 (7%) 4/50 (8%) | 5/48 (10%) 6/25 (24%) 1/21 (5%) 4/48 (8%) |
|ADJUSTED (b) | 8.1% 13.7% 12.2% 11.8% | 19.1% 100.0% 100.0% 14.8% |
|TERMINAL (d) | 1/26 (4%) 2/17 (12%) 2/20 (10%) 2/26 (8%) | 3/20 (15%) 2/2 (100%) 1/1 (100%) 4/27 (15%) |
|FIRST INCIDENCE (DAYS) | 463 571 592 522 | 588 466 749 (T) 749 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.490 P=0.581 P=0.608 P=0.528 | P=0.073N P=0.075 P=0.641N P=0.345N |
|INCIDENTAL TUMOR | P=0.433 P=0.478 P=0.564 P=0.360 | P=0.095N P=0.035 * P=0.724N P=0.397N |
|LOGISTIC REGRESSION | P=0.380 P=0.620 P=0.624 P=0.388 | P=0.170N P=0.092 P=0.491N P=0.455N |
|COCHRAN-ARMITAGE | P=0.423 | P=0.232N |
|FISHER EXACT | P=0.641 P=0.621 P=0.500 | P=0.117 P=0.402N P=0.500N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/36 (14%) 2/27 (7%) 2/48 (4%) | 0/48 (0%) 0/24 (0%) 1/20 (5%) 0/49 (0%) |
|ADJUSTED (b) | 3.7% 70.0% 100.0% 7.7% | 0.0% 0.0% 2.8% 0.0% |
|TERMINAL (d) | 0/26 (0%) 2/3 (67%) 1/1 (100%) 2/26 (8%) | 0/19 (0%) 0/1 (0%) 0/1 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 747 667 698 749 (T) | --- --- 680 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299N P=0.011 * P=0.225 P=0.496 | P=0.792N (e) P=0.550 (e) |
|INCIDENTAL TUMOR | P=0.371N P=0.061 P=0.354 P=0.511 | P=0.779 (e) P=0.362 (e) |
|LOGISTIC REGRESSION | P=0.303N P=0.012 * P=0.092 P=0.501 | P=0.708N (e) P=0.289 (e) |
|COCHRAN-ARMITAGE | P=0.419N | P=0.719N |
|FISHER EXACT | P=0.044 * P=0.280 P=0.485 | (e) P=0.294 (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/36 (3%) 2/27 (7%) 0/48 (0%) | 1/48 (2%) 0/24 (0%) 1/20 (5%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 33.3% 7.8% 0.0% | 3.3% 0.0% 100.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 1/3 (33%) 0/1 (0%) 0/26 (0%) | 0/19 (0%) 0/1 (0%) 1/1 (100%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | --- 749 (T) 702 --- | 668 --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.434N P=0.096 P=0.208 (e) | P=0.339N P=0.469N P=0.570 P=0.493N |
|INCIDENTAL TUMOR | P=0.502N P=0.096 P=0.329 (e) | P=0.376N P=0.567N P=0.411 P=0.612N |
|LOGISTIC REGRESSION | P=0.417N P=0.096 P=0.044 * (e) | P=0.354N P=0.658N P=0.456 P=0.503N |
|COCHRAN-ARMITAGE | P=0.484N | P=0.400N |
|FISHER EXACT | P=0.419 P=0.120 (e) | P=0.667N P=0.505 P=0.495N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 6/36 (17%) 4/27 (15%) 2/48 (4%) | 1/48 (2%) 0/24 (0%) 2/20 (10%) 0/49 (0%) |
|ADJUSTED (b) | 3.7% 100.0% 100.0% 7.7% | 3.3% 0.0% 100.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 3/3 (100%) 1/1 (100%) 2/26 (8%) | 0/19 (0%) 0/1 (0%) 1/1 (100%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 747 667 698 749 (T) | 668 --- 680 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.223N P=0.001 ** P=0.055 P=0.496 | P=0.349N P=0.469N P=0.321 P=0.493N |
|INCIDENTAL TUMOR | P=0.300N P=0.009 ** P=0.128 P=0.511 | P=0.416N P=0.567N P=0.127 P=0.612N |
|LOGISTIC REGRESSION | P=0.217N P=0.003 ** P=0.003 ** P=0.501 | P=0.335N P=0.658N P=0.126 P=0.503N |
|COCHRAN-ARMITAGE | P=0.333N | P=0.378N |
|FISHER EXACT | P=0.020 * P=0.048 * P=0.485 | P=0.667N P=0.205 P=0.495N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/44 (2%) 1/39 (3%) 0/50 (0%) | 0/49 (0%) 0/37 (0%) 2/30 (7%) 0/50 (0%) |
|ADJUSTED (b) | 3.8% 9.1% 4.5% 0.0% | 0.0% 0.0% 20.0% 0.0% |
|TERMINAL (d) | 1/26 (4%) 1/11 (9%) 0/11 (0%) 0/26 (0%) | 0/20 (0%) 0/11 (0%) 2/10 (20%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 749 (T) 745 --- | --- --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.275N P=0.559 P=0.642 P=0.500N | P=0.548N (e) P=0.102 (e) |
|INCIDENTAL TUMOR | P=0.291N P=0.559 P=0.723 P=0.500N | P=0.548N (e) P=0.102 (e) |
|LOGISTIC REGRESSION | P=0.270N P=0.559 P=0.588 P=0.500N | P=0.548N (e) P=0.102 (e) |
|COCHRAN-ARMITAGE | P=0.313N | P=0.653N |
|FISHER EXACT | P=0.720 P=0.687 P=0.500N | (e) P=0.141 (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/44 (2%) 1/39 (3%) 1/50 (2%) | 0/49 (0%) 0/37 (0%) 2/30 (7%) 0/50 (0%) |
|ADJUSTED (b) | 3.8% 9.1% 4.5% 3.4% | 0.0% 0.0% 20.0% 0.0% |
|TERMINAL (d) | 1/26 (4%) 1/11 (9%) 0/11 (0%) 0/26 (0%) | 0/20 (0%) 0/11 (0%) 2/10 (20%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 749 (T) 745 733 | --- --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.578N P=0.559 P=0.642 P=0.756N | P=0.548N (e) P=0.102 (e) |
|INCIDENTAL TUMOR | P=0.631N P=0.559 P=0.723 P=0.732N | P=0.548N (e) P=0.102 (e) |
|LOGISTIC REGRESSION | P=0.575N P=0.559 P=0.588 P=0.753N | P=0.548N (e) P=0.102 (e) |
|COCHRAN-ARMITAGE | P=0.643N | P=0.653N |
|FISHER EXACT | P=0.720 P=0.687 P=0.753N | (e) P=0.141 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 0/49 (0%) 2/50 (4%) | 3/49 (6%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 16.2% 0.0% 5.9% | 9.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/26 (8%) 2/17 (12%) 0/21 (0%) 1/26 (4%) | 0/20 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 737 --- 581 | 589 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.480N P=0.318 P=0.286N P=0.679N | P=0.127N P=0.099N P=0.095N P=0.104N |
|INCIDENTAL TUMOR | P=0.498N P=0.416 P=0.286N P=0.684N | P=0.172N P=0.160N P=0.217N P=0.183N |
|LOGISTIC REGRESSION | P=0.516N P=0.367 P=0.286N P=0.682N | P=0.136N P=0.117N P=0.121N P=0.124N |
|COCHRAN-ARMITAGE | P=0.549N | P=0.132N |
|FISHER EXACT | P=0.500 P=0.253N P=0.691N | P=0.117N P=0.117N P=0.117N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/49 (0%) 0/50 (0%) | 0/49 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.8% 0.0% 0.0% 0.0% | 0.0% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 508 --- --- --- | --- 749 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233N P=0.286N P=0.266N P=0.237N | P=0.544N P=0.536 (e) (e) |
|INCIDENTAL TUMOR | P=0.277N P=0.412N P=0.284N P=0.353N | P=0.544N P=0.536 (e) (e) |
|LOGISTIC REGRESSION | P=0.262N P=0.256N P=0.241N P=0.283N | P=0.544N P=0.536 (e) (e) |
|COCHRAN-ARMITAGE | P=0.243N | P=0.575N |
|FISHER EXACT | P=0.247N P=0.253N P=0.247N | P=0.505 (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 0/49 (0%) 2/50 (4%) | 3/49 (6%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 13.4% 16.2% 0.0% 5.9% | 9.7% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 3/26 (12%) 2/17 (12%) 0/21 (0%) 1/26 (4%) | 0/20 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 508 737 --- 581 | 589 749 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.252N P=0.623 P=0.086N P=0.324N | P=0.087N P=0.256N P=0.095N P=0.104N |
|INCIDENTAL TUMOR | P=0.288N P=0.636 P=0.093N P=0.406N | P=0.117N P=0.346N P=0.217N P=0.183N |
|LOGISTIC REGRESSION | P=0.289N P=0.500N P=0.066N P=0.350N | P=0.096N P=0.297N P=0.121N P=0.124N |
|COCHRAN-ARMITAGE | P=0.302N | P=0.096N |
|FISHER EXACT | P=0.500N P=0.061N P=0.339N | P=0.301N P=0.117N P=0.117N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 0/49 (0%) 2/50 (4%) | 3/49 (6%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 13.4% 16.2% 0.0% 5.9% | 9.7% 4.2% 0.0% 0.0% |
|TERMINAL (d) | 3/26 (12%) 2/17 (12%) 0/21 (0%) 1/26 (4%) | 0/20 (0%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 508 737 --- 581 | 589 749 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.252N P=0.623 P=0.086N P=0.324N | P=0.087N P=0.256N P=0.095N P=0.104N |
|INCIDENTAL TUMOR | P=0.288N P=0.636 P=0.093N P=0.406N | P=0.117N P=0.346N P=0.217N P=0.183N |
|LOGISTIC REGRESSION | P=0.289N P=0.500N P=0.066N P=0.350N | P=0.096N P=0.297N P=0.121N P=0.124N |
|COCHRAN-ARMITAGE | P=0.302N | P=0.096N |
|FISHER EXACT | P=0.500N P=0.061N P=0.339N | P=0.301N P=0.117N P=0.117N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/49 (4%) 1/50 (2%) 0/50 (0%) | 2/49 (4%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 15.4% 10.0% 2.9% 0.0% | 10.0% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 4/26 (15%) 1/17 (6%) 0/21 (0%) 0/26 (0%) | 2/20 (10%) 0/24 (0%) 1/29 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 728 667 --- | 749 (T) --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044N* P=0.528N P=0.232N P=0.061N | P=0.225N P=0.198N P=0.370N P=0.174N |
|INCIDENTAL TUMOR | P=0.047N* P=0.443N P=0.205N P=0.061N | P=0.225N P=0.198N P=0.370N P=0.174N |
|LOGISTIC REGRESSION | P=0.045N* P=0.455N P=0.200N P=0.061N | P=0.225N P=0.198N P=0.370N P=0.174N |
|COCHRAN-ARMITAGE | P=0.052N | P=0.268N |
|FISHER EXACT | P=0.349N P=0.181N P=0.059N | P=0.242N P=0.492N P=0.242N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/49 (4%) 0/50 (0%) 0/50 (0%) | 0/49 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 8.4% 0.0% 0.0% | 0.0% 0.0% 6.9% 0.0% |
|TERMINAL (d) | 0/26 (0%) 1/17 (6%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 2/29 (7%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | --- 667 --- --- | --- --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.354N P=0.205 (e) (e) | P=0.655N (e) P=0.323 (e) |
|INCIDENTAL TUMOR | P=0.366N P=0.268 (e) (e) | P=0.655N (e) P=0.323 (e) |
|LOGISTIC REGRESSION | P=0.359N P=0.234 (e) (e) | P=0.655N (e) P=0.323 (e) |
|COCHRAN-ARMITAGE | P=0.367N | P=0.695N |
|FISHER EXACT | P=0.242 (e) (e) | (e) P=0.253 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/49 (8%) 1/50 (2%) 0/50 (0%) | 2/49 (4%) 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 15.4% 17.8% 2.9% 0.0% | 10.0% 0.0% 10.3% 0.0% |
|TERMINAL (d) | 4/26 (15%) 2/17 (12%) 0/21 (0%) 0/26 (0%) | 2/20 (10%) 0/24 (0%) 3/29 (10%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 667 667 --- | 749 (T) --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.024N* P=0.453 P=0.232N P=0.061N | P=0.234N P=0.198N P=0.669 P=0.174N |
|INCIDENTAL TUMOR | P=0.026N* P=0.576 P=0.205N P=0.061N | P=0.234N P=0.198N P=0.669 P=0.174N |
|LOGISTIC REGRESSION | P=0.024N* P=0.589 P=0.200N P=0.061N | P=0.234N P=0.198N P=0.669 P=0.174N |
|COCHRAN-ARMITAGE | P=0.029N* | P=0.294N |
|FISHER EXACT | P=0.631 P=0.181N P=0.059N | P=0.242N P=0.510 P=0.242N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 5.0% 6.8% 2.1% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 1/20 (5%) 1/24 (4%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 749 (T) 666 536 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.210N P=0.552 P=0.720N P=0.440N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.237N P=0.524 P=0.693N P=0.440N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.235N P=0.528 P=0.756 P=0.440N |
|COCHRAN-ARMITAGE | (e) | P=0.231N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.753N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 3/50 (6%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 5.0% 10.9% 2.1% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 1/20 (5%) 2/24 (8%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 749 (T) 666 536 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.144N P=0.363 P=0.720N P=0.440N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.163N P=0.341 P=0.693N P=0.440N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.167N P=0.341 P=0.756 P=0.440N |
|COCHRAN-ARMITAGE | (e) | P=0.169N |
|FISHER EXACT | (e) (e) (e) | P=0.309 P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 16/50 (32%) 11/50 (22%) 13/50 (26%) 17/50 (34%) |
|ADJUSTED (b) | 3.8% 0.0% 0.0% 3.8% | 51.0% 40.9% 39.8% 44.0% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 0/21 (0%) 1/26 (4%) | 7/20 (35%) 9/24 (38%) 10/29 (34%) 8/27 (30%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- --- 749 (T) | 543 601 563 476 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.441 P=0.100N P=0.106N P=0.437N |
|INCIDENTAL TUMOR | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.294 P=0.159N P=0.285N P=0.488 |
|LOGISTIC REGRESSION | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.280 P=0.153N P=0.262N P=0.489 |
|COCHRAN-ARMITAGE | P=0.536 | P=0.250 |
|FISHER EXACT | P=0.500N P=0.500N P=0.753N | P=0.184N P=0.330N P=0.500 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 16/50 (32%) 12/50 (24%) 13/50 (26%) 17/50 (34%) |
|ADJUSTED (b) | 3.8% 0.0% 0.0% 3.8% | 51.0% 44.8% 39.8% 44.0% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 0/21 (0%) 1/26 (4%) | 7/20 (35%) 10/24 (42%) 10/29 (34%) 8/27 (30%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- --- 749 (T) | 543 601 563 476 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.485 P=0.141N P=0.106N P=0.437N |
|INCIDENTAL TUMOR | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.336 P=0.215N P=0.285N P=0.488 |
|LOGISTIC REGRESSION | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.319 P=0.212N P=0.262N P=0.489 |
|COCHRAN-ARMITAGE | P=0.536 | P=0.286 |
|FISHER EXACT | P=0.500N P=0.500N P=0.753N | P=0.252N P=0.330N P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 17/50 (34%) 13/50 (26%) 14/50 (28%) 17/50 (34%) |
|ADJUSTED (b) | 3.8% 0.0% 0.0% 3.8% | 54.7% 46.3% 41.1% 44.0% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 0/21 (0%) 1/26 (4%) | 8/20 (40%) 10/24 (42%) 10/29 (34%) 8/27 (30%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- --- 749 (T) | 543 601 536 476 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.515N P=0.141N P=0.106N P=0.355N |
|INCIDENTAL TUMOR | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.426 P=0.219N P=0.268N P=0.582N |
|LOGISTIC REGRESSION | P=0.572 P=0.585N P=0.543N P=0.762 | P=0.414 P=0.214N P=0.277N P=0.580 |
|COCHRAN-ARMITAGE | P=0.536 | P=0.380 |
|FISHER EXACT | P=0.500N P=0.500N P=0.753N | P=0.257N P=0.333N P=0.583N |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/42 (5%) 1/32 (3%) 0/27 (0%) 0/41 (0%) | 0/40 (0%) 0/22 (0%) 0/18 (0%) 0/43 (0%) |
|ADJUSTED (b) | 6.8% 100.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/23 (4%) 1/1 (100%) 0/0 0/19 (0%) | 0/17 (0%) 0/2 (0%) 0/0 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 585 749 (T) --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.149N P=0.579 P=0.485N P=0.244N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.151N P=0.535 P=0.527N P=0.261N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.158N P=0.628N P=0.336N P=0.258N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.165N | (e) |
|FISHER EXACT | P=0.602N P=0.367N P=0.253N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/47 (53%) 25/43 (58%) 25/40 (63%) 25/47 (53%) | 28/48 (58%) 26/44 (59%) 32/42 (76%) 32/49 (65%) |
|ADJUSTED (b) | 67.4% 94.2% 89.2% 69.9% | 83.7% 84.9% 93.4% 83.5% |
|TERMINAL (d) | 14/25 (56%) 9/10 (90%) 10/12 (83%) 15/25 (60%) | 15/20 (75%) 15/19 (79%) 20/22 (91%) 21/27 (78%) |
|FIRST INCIDENCE (DAYS) | 438 485 389 612 | 507 519 457 505 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181N P=0.050 * P=0.085 P=0.525N | P=0.375N P=0.385N P=0.539 P=0.396N |
|INCIDENTAL TUMOR | P=0.395N P=0.197 P=0.177 P=0.558 | P=0.417 P=0.556 P=0.083 P=0.415 |
|LOGISTIC REGRESSION | P=0.378N P=0.375 P=0.149 P=0.547N | P=0.384 P=0.576 P=0.068 P=0.401 |
|COCHRAN-ARMITAGE | P=0.447N | P=0.285 |
|FISHER EXACT | P=0.398 P=0.256 P=0.582N | P=0.555 P=0.058 P=0.309 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 3/43 (7%) 2/40 (5%) 2/47 (4%) | 2/48 (4%) 3/44 (7%) 2/42 (5%) 3/49 (6%) |
|ADJUSTED (b) | 2.8% 9.6% 16.7% 8.0% | 7.4% 10.0% 4.7% 7.5% |
|TERMINAL (d) | 0/25 (0%) 0/10 (0%) 2/12 (17%) 2/25 (8%) | 1/20 (5%) 1/19 (5%) 0/22 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 655 553 749 (T) 749 (T) | 589 508 549 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.550N P=0.297 P=0.335 P=0.509 | P=0.544 P=0.511 P=0.671N P=0.555 |
|INCIDENTAL TUMOR | P=0.604N P=0.554 P=0.379 P=0.521 | P=0.478 P=0.475 P=0.619 P=0.457 |
|LOGISTIC REGRESSION | P=0.608N P=0.277 P=0.390 P=0.517 | P=0.462 P=0.461 P=0.633 P=0.470 |
|COCHRAN-ARMITAGE | P=0.603 | P=0.516 |
|FISHER EXACT | P=0.275 P=0.439 P=0.500 | P=0.458 P=0.640 P=0.510 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 26/47 (55%) 28/43 (65%) 27/40 (68%) 27/47 (57%) | 30/48 (63%) 29/44 (66%) 34/42 (81%) 35/49 (71%) |
|ADJUSTED (b) | 68.3% 94.7% 100.0% 75.9% | 87.3% 89.3% 93.7% 84.7% |
|TERMINAL (d) | 14/25 (56%) 9/10 (90%) 12/12 (100%) 17/25 (68%) | 16/20 (80%) 16/19 (84%) 20/22 (91%) 21/27 (78%) |
|FIRST INCIDENCE (DAYS) | 438 485 389 612 | 507 508 457 505 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.170N P=0.029 * P=0.049 * P=0.546 | P=0.404N P=0.452N P=0.546 P=0.446N |
|INCIDENTAL TUMOR | P=0.387N P=0.151 P=0.099 P=0.483 | P=0.350 P=0.454 P=0.067 P=0.310 |
|LOGISTIC REGRESSION | P=0.372N P=0.218 P=0.086 P=0.544 | P=0.314 P=0.458 P=0.051 P=0.302 |
|COCHRAN-ARMITAGE | P=0.453N | P=0.239 |
|FISHER EXACT | P=0.232 P=0.174 P=0.500 | P=0.451 P=0.044 * P=0.236 |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 2.3% 12.1% 9.9% | 0.0% 0.0% 3.4% 3.4% |
|TERMINAL (d) | 0/26 (0%) 0/17 (0%) 2/21 (10%) 2/26 (8%) | 0/20 (0%) 0/24 (0%) 1/29 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | --- 586 667 638 | --- --- 749 (T) 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145 P=0.529 P=0.100 P=0.130 | P=0.336 (e) P=0.574 P=0.546 |
|INCIDENTAL TUMOR | P=0.138 P=0.500 P=0.118 P=0.129 | P=0.284 (e) P=0.574 P=0.412 |
|LOGISTIC REGRESSION | P=0.113 P=0.461 P=0.111 P=0.128 | P=0.316 (e) P=0.574 P=0.517 |
|COCHRAN-ARMITAGE | P=0.107 | P=0.303 |
|FISHER EXACT | P=0.500 P=0.121 P=0.121 | (e) P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 0.0% 0.0% 0.0% | 0.0% 0.0% 6.1% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 1/29 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) --- --- --- | --- --- 680 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.224N P=0.335N P=0.286N P=0.238N | P=0.678N (e) P=0.310 (e) |
|INCIDENTAL TUMOR | P=0.224N P=0.335N P=0.286N P=0.238N | P=0.716N (e) P=0.214 (e) |
|LOGISTIC REGRESSION | P=0.224N P=0.335N P=0.286N P=0.238N | P=0.688N (e) P=0.256 (e) |
|COCHRAN-ARMITAGE | P=0.242N | P=0.697N |
|FISHER EXACT | P=0.247N P=0.247N P=0.247N | (e) P=0.247 (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 3/50 (6%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 7.7% 2.3% 12.1% 9.9% | 0.0% 0.0% 9.5% 3.4% |
|TERMINAL (d) | 2/26 (8%) 0/17 (0%) 2/21 (10%) 2/26 (8%) | 0/20 (0%) 0/24 (0%) 2/29 (7%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 586 667 638 | --- --- 680 716 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385 P=0.581N P=0.425 P=0.512 | P=0.422 (e) P=0.187 P=0.546 |
|INCIDENTAL TUMOR | P=0.379 P=0.598N P=0.458 P=0.511 | P=0.353 (e) P=0.128 P=0.412 |
|LOGISTIC REGRESSION | P=0.342 P=0.498N P=0.465 P=0.529 | P=0.399 (e) P=0.144 P=0.517 |
|COCHRAN-ARMITAGE | P=0.318 | P=0.381 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500 | (e) P=0.121 P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 2.6% 0.0% 7.4% | 0.0% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 1/29 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 667 --- 581 | --- --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306 P=0.585N P=0.286N P=0.537 | P=0.761N (e) P=0.574 (e) |
|INCIDENTAL TUMOR | P=0.273 P=0.506N P=0.286N P=0.545 | P=0.761N (e) P=0.574 (e) |
|LOGISTIC REGRESSION | P=0.248 P=0.506N P=0.286N P=0.486 | P=0.761N (e) P=0.574 (e) |
|COCHRAN-ARMITAGE | P=0.256 | P=0.786N |
|FISHER EXACT | P=0.500N P=0.247N P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 2.6% 0.0% 7.4% | 0.0% 3.3% 3.4% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 1/29 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 667 --- 581 | --- 715 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306 P=0.585N P=0.286N P=0.537 | P=0.501N P=0.553 P=0.574 (e) |
|INCIDENTAL TUMOR | P=0.273 P=0.506N P=0.286N P=0.545 | P=0.556N P=0.469 P=0.574 (e) |
|LOGISTIC REGRESSION | P=0.248 P=0.506N P=0.286N P=0.486 | P=0.521N P=0.512 P=0.574 (e) |
|COCHRAN-ARMITAGE | P=0.256 | P=0.536N |
|FISHER EXACT | P=0.500N P=0.247N P=0.500 | P=0.500 P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 31/50 (62%) 38/47 (81%) 36/50 (72%) 41/50 (82%) | |
|ADJUSTED (b) | 83.2% 97.0% 97.1% 93.0% | |
|TERMINAL (d) | 20/26 (77%) 13/14 (93%) 20/21 (95%) 23/26 (88%) | |
|FIRST INCIDENCE (DAYS) | 508 560 529 473 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.465 P=0.004 ** P=0.063 P=0.096 | |
|INCIDENTAL TUMOR | P=0.132 P=0.057 P=0.115 P=0.034 * | |
|LOGISTIC REGRESSION | P=0.137 P=0.033 * P=0.150 P=0.041 * | |
|COCHRAN-ARMITAGE | P=0.069 | |
|FISHER EXACT | P=0.033 * P=0.198 P=0.022 * | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 9/49 (18%) 7/46 (15%) 6/48 (13%) | 4/48 (8%) 2/26 (8%) 0/18 (0%) 3/50 (6%) |
|ADJUSTED (b) | 7.7% 35.5% 22.8% 17.2% | 15.2% 27.7% 0.0% 11.1% |
|TERMINAL (d) | 2/26 (8%) 2/17 (12%) 2/20 (10%) 2/26 (8%) | 2/20 (10%) 1/4 (25%) 0/0 3/27 (11%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 702 571 577 | 641 720 --- 749 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.543 P=0.009 ** P=0.060 P=0.157 | P=0.280N P=0.653N P=0.227N P=0.385N |
|INCIDENTAL TUMOR | P=0.409 P=0.086 P=0.068 P=0.164 | P=0.308N P=0.602 P=0.371N P=0.425N |
|LOGISTIC REGRESSION | P=0.450 P=0.078 P=0.071 P=0.139 | P=0.337N P=0.618 P=0.346N P=0.441N |
|COCHRAN-ARMITAGE | P=0.428 | P=0.444N |
|FISHER EXACT | P=0.028 * P=0.070 P=0.134 | P=0.648N P=0.270N P=0.477N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 1/49 (2%) 2/46 (4%) 0/48 (0%) | 1/48 (2%) 1/26 (4%) 0/18 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.0% 6.7% 0.0% | 5.0% 25.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/17 (0%) 0/20 (0%) 0/26 (0%) | 1/20 (5%) 1/4 (25%) 0/0 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | --- 737 687 --- | 749 (T) 749 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.490N P=0.433 P=0.225 (e) | P=0.176N P=0.373 (e) P=0.440N |
|INCIDENTAL TUMOR | P=0.594N P=0.678 P=0.354 (e) | P=0.176N P=0.373 (e) P=0.440N |
|LOGISTIC REGRESSION | P=0.506N P=0.479 P=0.228 (e) | P=0.176N P=0.373 (e) P=0.440N |
|COCHRAN-ARMITAGE | P=0.517N | P=0.265N |
|FISHER EXACT | P=0.505 P=0.237 (e) | P=0.582 P=0.727N P=0.490N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 10/49 (20%) 9/46 (20%) 6/48 (13%) | 5/48 (10%) 3/26 (12%) 0/18 (0%) 3/50 (6%) |
|ADJUSTED (b) | 7.7% 38.7% 28.0% 17.2% | 19.9% 51.8% 0.0% 11.1% |
|TERMINAL (d) | 2/26 (8%) 2/17 (12%) 2/20 (10%) 2/26 (8%) | 3/20 (15%) 2/4 (50%) 0/0 3/27 (11%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 702 571 577 | 641 720 --- 749 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.520N P=0.005 ** P=0.021 * P=0.157 | P=0.114N P=0.471 P=0.227N P=0.241N |
|INCIDENTAL TUMOR | P=0.454 P=0.063 P=0.032 * P=0.164 | P=0.130N P=0.363 P=0.371N P=0.272N |
|LOGISTIC REGRESSION | P=0.521 P=0.052 P=0.023 * P=0.139 | P=0.163N P=0.442 P=0.310N P=0.292N |
|COCHRAN-ARMITAGE | P=0.496 | P=0.261N |
|FISHER EXACT | P=0.015 * P=0.021 * P=0.134 | P=0.583 P=0.192N P=0.335N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/48 (0%) 2/49 (4%) 1/46 (2%) 1/48 (2%) | 0/48 (0%) 1/26 (4%) 0/18 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 11.8% 5.0% 3.8% | 0.0% 25.0% 0.0% 3.7% |
|TERMINAL (d) | 0/26 (0%) 2/17 (12%) 1/20 (5%) 1/26 (4%) | 0/20 (0%) 1/4 (25%) 0/0 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | --- 749 (T) 749 (T) 749 (T) | --- 749 (T) --- 749 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.655N P=0.150 P=0.448 P=0.500 | P=0.673 P=0.186 (e) P=0.560 |
|INCIDENTAL TUMOR | P=0.655N P=0.150 P=0.448 P=0.500 | P=0.673 P=0.186 (e) P=0.560 |
|LOGISTIC REGRESSION | P=0.655N P=0.150 P=0.448 P=0.500 | P=0.673 P=0.186 (e) P=0.560 |
|COCHRAN-ARMITAGE | P=0.616 | P=0.537 |
|FISHER EXACT | P=0.253 P=0.489 P=0.500 | P=0.351 (e) P=0.510 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 5/50 (10%) 7/50 (14%) 5/50 (10%) 8/50 (16%) |
|ADJUSTED (b) | | 19.2% 23.5% 13.8% 21.5% |
|TERMINAL (d) | | 2/20 (10%) 4/24 (17%) 1/29 (3%) 3/27 (11%) |
|FIRST INCIDENCE (DAYS) | | 576 568 465 522 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.378 P=0.482 P=0.472N P=0.398 |
|INCIDENTAL TUMOR | | P=0.248 P=0.346 P=0.513 P=0.251 |
|LOGISTIC REGRESSION | | P=0.270 P=0.395 P=0.630 P=0.258 |
|COCHRAN-ARMITAGE | | P=0.278 |
|FISHER EXACT | | P=0.380 P=0.630N P=0.277 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 6.6% 2.0% 0.0% 2.3% | 0.0% 2.7% 0.0% 5.6% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 666 485 --- 625 | --- 612 --- 633 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.478N P=0.537N P=0.263N P=0.479N | P=0.172 P=0.500 (e) P=0.270 |
|INCIDENTAL TUMOR | P=0.540N P=0.578N P=0.217N P=0.456N | P=0.132 P=0.419 (e) P=0.174 |
|LOGISTIC REGRESSION | P=0.549N P=0.530N P=0.243N P=0.512N | P=0.136 P=0.507 (e) P=0.226 |
|COCHRAN-ARMITAGE | P=0.500N | P=0.151 |
|FISHER EXACT | P=0.500N P=0.247N P=0.500N | P=0.500 (e) P=0.247 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 35/50 (70%) 30/50 (60%) 28/50 (56%) | 24/50 (48%) 24/50 (48%) 21/50 (42%) 33/50 (66%) |
|ADJUSTED (b) | 71.3% 86.0% 73.4% 72.2% | 67.5% 61.3% 54.3% 79.8% |
|TERMINAL (d) | 15/26 (58%) 12/17 (71%) 11/21 (52%) 16/26 (62%) | 10/20 (50%) 10/24 (42%) 12/29 (41%) 19/27 (70%) |
|FIRST INCIDENCE (DAYS) | 508 553 389 577 | 487 438 563 522 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.134N P=0.054 P=0.311 P=0.440N | P=0.157 P=0.368N P=0.099N P=0.330 |
|INCIDENTAL TUMOR | P=0.193N P=0.224 P=0.568 P=0.431N | P=0.020 * P=0.543 P=0.428N P=0.059 |
|LOGISTIC REGRESSION | P=0.193N P=0.261 P=0.493 P=0.453N | P=0.026 * P=0.578N P=0.306N P=0.065 |
|COCHRAN-ARMITAGE | P=0.242N | P=0.023 * |
|FISHER EXACT | P=0.149 P=0.500 P=0.500N | P=0.579N P=0.344N P=0.053 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.9% 0.0% 0.0% 0.0% | 0.0% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 1/29 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 699 --- --- --- | --- --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233N P=0.298N P=0.279N P=0.240N | P=0.761N (e) P=0.574 (e) |
|INCIDENTAL TUMOR | P=0.242N P=0.189N P=0.217N P=0.211N | P=0.761N (e) P=0.574 (e) |
|LOGISTIC REGRESSION | P=0.233N P=0.242N P=0.248N P=0.224N | P=0.761N (e) P=0.574 (e) |
|COCHRAN-ARMITAGE | P=0.242N | P=0.786N |
|FISHER EXACT | P=0.247N P=0.247N P=0.247N | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.9% 0.0% 0.0% 0.0% | 0.0% 0.0% 3.4% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/17 (0%) 0/21 (0%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 1/29 (3%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 699 --- --- --- | --- --- 749 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233N P=0.298N P=0.279N P=0.240N | P=0.761N (e) P=0.574 (e) |
|INCIDENTAL TUMOR | P=0.242N P=0.189N P=0.217N P=0.211N | P=0.761N (e) P=0.574 (e) |
|LOGISTIC REGRESSION | P=0.233N P=0.242N P=0.248N P=0.224N | P=0.761N (e) P=0.574 (e) |
|COCHRAN-ARMITAGE | P=0.242N | P=0.786N |
|FISHER EXACT | P=0.247N P=0.247N P=0.247N | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.8% 12.8% 11.5% 2.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/26 (4%) 1/17 (6%) 2/21 (10%) 0/26 (0%) | 0/20 (0%) 0/24 (0%) 0/29 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 749 (T) 690 536 606 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.360N P=0.216 P=0.252 P=0.742N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.421N P=0.368 P=0.250 P=0.747N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.407N P=0.288 P=0.300 P=0.756 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.414N | (e) |
|FISHER EXACT | P=0.309 P=0.309 P=0.753N | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 46/50 (92%) 45/50 (90%) 47/50 (94%) 48/50 (96%) | 41/50 (82%) 35/50 (70%) 40/50 (80%) 43/50 (86%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 98.0% | 97.5% 84.8% 86.8% 97.6% |
|TERMINAL (d) | 26/26 (100%) 17/17 (100%) 21/21 (100%) 25/26 (96%) | 19/20 (95%) 18/24 (75%) 23/29 (79%) 26/27 (96%) |
|FIRST INCIDENCE (DAYS) | 438 485 389 473 | 465 466 457 476 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.319N P=0.124 P=0.197 P=0.536 | P=0.470N P=0.062N P=0.063N P=0.208N |
|INCIDENTAL TUMOR | P=0.250 P=0.586N P=0.406 P=0.354 | P=0.151 P=0.109N P=0.433N P=0.548 |
|LOGISTIC REGRESSION | P=0.272 P=0.405N P=0.478 P=0.412 | P=0.165 P=0.105N P=0.455N P=0.474 |
|COCHRAN-ARMITAGE | P=0.200 | P=0.128 |
|FISHER EXACT | P=0.500N P=0.500 P=0.339 | P=0.121N P=0.500N P=0.393 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ | CONTROL .075 MG/ 0.25 MG/ 0.75 MG/ |
| | M3 M3 M3 | M3 M3 M3 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 42/50 (84%) 37/50 (74%) 37/50 (74%) | 28/50 (56%) 32/50 (64%) 29/50 (58%) 37/50 (74%) |
|ADJUSTED (b) | 79.6% 95.2% 81.5% 81.5% | 75.5% 72.2% 69.9% 83.8% |
|TERMINAL (d) | 18/26 (69%) 15/17 (88%) 13/21 (62%) 18/26 (69%) | 12/20 (60%) 12/24 (50%) 17/29 (59%) 20/27 (74%) |
|FIRST INCIDENCE (DAYS) | 508 485 389 473 | 487 438 536 522 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282N P=0.014 * P=0.165 P=0.400 | P=0.309 P=0.554 P=0.212N P=0.379 |
|INCIDENTAL TUMOR | P=0.553 P=0.044 * P=0.308 P=0.282 | P=0.039 * P=0.226 P=0.451 P=0.046 * |
|LOGISTIC REGRESSION | P=0.555 P=0.035 * P=0.254 P=0.264 | P=0.059 P=0.272 P=0.537 P=0.057 |
|COCHRAN-ARMITAGE | P=0.532 | P=0.050 * |
|FISHER EXACT | P=0.032 * P=0.257 P=0.257 | P=0.270 P=0.500 P=0.046 * |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 49/50 (98%) 50/50 (100%) 50/50 (100%)| 47/50 (94%) 47/50 (94%) 47/50 (94%) 50/50 (100%)|
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 100.0% 94.0% 94.0% 100.0% |
|TERMINAL (d) | 26/26 (100%) 17/17 (100%) 21/21 (100%) 26/26 (100%)| 20/20 (100%) 21/24 (88%) 26/29 (90%) 27/27 (100%)|
|FIRST INCIDENCE (DAYS) | 438 485 389 473 | 465 438 370 476 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215N P=0.151 P=0.254 P=0.454N | P=0.339N P=0.254N P=0.078N P=0.245N |
|INCIDENTAL TUMOR | P=0.706 P=0.282N (e) (e) | P=0.068 P=0.631N P=0.646N P=0.171 |
|LOGISTIC REGRESSION | P=0.797 P=0.282N (e) (e) | P=0.073 P=0.653 P=0.648 P=0.133 |
|COCHRAN-ARMITAGE | P=0.576 | P=0.082 |
|FISHER EXACT | P=0.500N P=1.000N P=1.000N | P=0.661N P=0.661N P=0.121 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05096 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 0-CHLOROBENZALMALONONITRILE (CS-2)
TERMINAL SACRIFICE AT 107 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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