TDMS Study 05096-01 Pathology Tables
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
Facility: Battelle Northwest
Chemical CAS #: 2698-41-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + A + + + + + + A I + A + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + + A + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + I + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + A I + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A I + + + + + + + + + + + + + + + I I + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A I A + + + + + I A + A A + + I + I + A + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A I A + + + + + A A I + A + + I + I I + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 2 1 1 1 1 1 1 1 3 1|
Clear Cell Focus | 1 |
Congestion | 2 |
Degeneration, Fatty | 2 3 2 2 2 3 1 1 2 1 3 1 |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X X X X|
Inflammation, Focal, Granulomatous | 1 1 2 1 2 1 1 2 2 1 |
Leukocytosis | 2 2 |
Necrosis | 2 2 2 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 2 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 |
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 1 1 1 1 1 1 1|
Duct, Hyperplasia | 1 1 2 1 1 1 1 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 |
Ulcer | 2 2 |
Epithelium, Hyperplasia | 3 2 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hemorrhage | 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 1 2 |
Pigmentation, Hemosiderin | |
Ulcer | 1 2 1 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 2 2 1 1 1 1 2 1 2 2 1 1 1 2 1 2 1|
Atrium, Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 1 1 2 1 1 1 1 4 3 1|
Focal Cellular Change | 1 1 1 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia | 3 3 2 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + I M + M + M + M + M + I + I + + I + +|
Hyperplasia | 1 2 2 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + I + + + + M + M + + + + + + + + + + M|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Angiectasis | 4 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 4 1 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 2 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | 1 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Granulomatous | |
Myelofibrosis | 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, Focal, | |
Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + I + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + M M + M +|
Hyperplasia | 2 2 2 2 2 |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 1 1 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Granulomatous | 3 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 2 |
Capsule, Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 1 |
Hyperplasia | 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 |
Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 |
Hydrocephalus | 2 2 |
Meninges, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 1 1 2 1 1 1|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 2 1 1 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | 1 1 1 1 2 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 1 |
Mediastinum, Inflammation, Chronic | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 2 1 2 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Thrombosis | 3 3 2 3|
Nares, Inflammation, Chronic | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 1 2 1|
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Hyperplasia | |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Eye | + + + + + + + + + + A + + + + + + + + + + + + + +|
Anterior Chamber, Inflammation, | |
Suppurative | |
Lens, Degeneration | 2 1 2 |
Retina, Degeneration | 3 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Suppurative | 1 1 1 |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Suppurative | 1 |
Acinus, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|
| 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Mineralization | |
Nephropathy | 3 2 1 2 2 2 3 2 2 3 1 2 1 2 2 1 1 3 2 4 2 4 2|
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + M + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + I A A + + + + + + + + + + + + + A + +| 40 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + I + + + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + I + + + + + + + + + + + + + + + I +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + I I A + + + + I I + I + + I + + A + +| 31 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + A + I + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 1 1 4 3 | 5 2.2|
Basophilic Focus | 2 1 2 2 2 1 1 1 1 1 2 1 1 1| 25 1.3|
Clear Cell Focus | 2 | 2 1.5|
Congestion | | 1 2.0|
Degeneration, Fatty | 2 2 3 2 1 2| 18 1.9|
Hematopoietic Cell Proliferation | 1 3 2 1 1 | 7 1.4|
Hepatodiaphragmatic Nodule | X X | 6 |
Inflammation, Focal, Granulomatous | 2 1 3 1 1 1 1 1 2 1 1 1 1 | 23 1.3|
Leukocytosis | | 2 2.0|
Necrosis | 2 2 2 2 2 | 10 1.8|
Bile Duct, Hyperplasia | 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Hemorrhage | 3 | 1 3.0|
Fat, Inflammation, Chronic | 2 2 | 3 2.3|
Fat, Necrosis | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 1 2 3 2 1 1 | 11 1.4|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2| 2 2.0|
Inflammation, Suppurative | 1 1 1 1 1 1 2 1 2| 16 1.1|
Duct, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 2 1 1 | 22 1.2|
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + I + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 3| 3 2.3|
Inflammation, Suppurative | 2 3 | 4 2.3|
Ulcer | 3 3 2| 5 2.4|
Epithelium, Hyperplasia | 1 2 1 3 1 3| 10 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 2.0|
Inflammation, Chronic | 3 3 3 2 2| 5 2.6|
Inflammation, Suppurative | | 2 1.5|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Ulcer | 3 4 4 3 4| 9 2.8|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 2 2 2 2 3 1 2 2 2 2 2 2 1 2 1 1 1 2 1 | 42 1.5|
Atrium, Thrombosis | 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 1 2 2 1 2 3 3 1 1 2 1 1 2 2| 26 1.6|
Focal Cellular Change | 1 1 2| 6 1.2|
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 1 1 | 10 1.3|
Hyperplasia | 2 3 2 2 | 7 2.4|
Necrosis | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A + + + + + M + + + + + + M + + + + M + + + + +| 37 |
Hyperplasia | 2 2 2 1 1 | 10 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + M + + + + M + + + + + + + + + + + M +| 40 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 3 2.7|
Pars Distalis, Cyst | 1 3 | 3 2.0|
Pars Distalis, Hyperplasia | 3 1 2 3 2 2 | 10 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + I +| 48 |
C-Cell, Hyperplasia | 1 1 2 2 1 | 10 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 1 3 3 3 2 1 1 1| 11 1.7|
__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Cyst | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 2 4 | 2 3.0|
Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Myelofibrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mediastinal, Inflammation, Focal, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 2 2 1 2 1 2 2 2 1 1 | 15 1.7|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Developmental Malformation | X | 1 |
Fibrosis | 1 2 | 5 1.4|
Hematopoietic Cell Proliferation | 3 3 3 2 2 | 6 2.5|
Inflammation, Granulomatous | | 1 3.0|
Necrosis | 2 | 2 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Capsule, Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + A + + + + M M + + + + + + + + + + + + + + + + M| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + A + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Galactocele | | 2 1.0|
Hyperplasia | 3 2 2 2 | 6 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1| 3 1.0|
Osteopetrosis | 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 2 2 | 6 1.8|
Hydrocephalus | 2 | 3 2.0|
Meninges, Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1 2 1 2 1 1 1 2 1 2| 22 1.3|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 2 3.5|
Hemorrhage | | 3 1.3|
Infiltration Cellular, Mixed Cell | 3 2 2 | 3 2.3|
Inflammation, Chronic, Focal | 1 1 2 1 1 1 1 2 | 16 1.2|
Alveolar Epithelium, Hyperplasia | 4 3| 4 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 | 6 1.2|
Mediastinum, Inflammation, Chronic | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 2 | 18 1.2|
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 2 1 2 1 2 2 1 1 1 1 1 1 1 2 2 1 2 1| 37 1.3|
Inflammation, Suppurative | 1 1 2 1 1 1 2 2 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1| 46 1.1|
Thrombosis | 2 3 3 3 | 8 2.8|
Nares, Inflammation, Chronic | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 1 1 2 1 2 1 2| 14 1.4|
Olfactory Epithelium, Metaplasia | 2 1 | 3 1.3|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 3 1.0|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2 2 1 1 2 1 | 12 1.3|
__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6| |
DAY ON TEST | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8| |
| 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 3 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Eye | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Anterior Chamber, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Lens, Degeneration | 1 2 | 5 1.6|
Retina, Degeneration | 3 1| 4 2.5|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Inflammation, Suppurative | 3 | 4 1.5|
__________________________________________________________________________|____________|
Lacrimal Gland | + + | 3 |
Inflammation, Suppurative | | 1 1.0|
Acinus, Atrophy | 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 2 3 1 2 2 3 1 3 2 3 1 2 1 3 1 1 3 1 1 2 2 4| 45 2.1|
Renal Tubule, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A A + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + I + + A A + + A + A|
Inflammation, Suppurative | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + I + + + A + + A A + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + A A + + A + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + I + + + A + + A A + I A A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + I + I + + + A A A + A A I +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 |
Basophilic Focus | X 2 2 1 2 1 1 1 1 X |
Clear Cell Focus | |
Degeneration, Fatty | 3 3 2 1 1 3 3 2 3 1 |
Hematopoietic Cell Proliferation | 1 3 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 3 |
Inflammation, Focal, Granulomatous | 2 3 1 2 1 2 1 2 2 1 2 1 |
Leukocytosis | 1 |
Necrosis | 2 3 1 2 1 2 1|
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 1 2 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + +|
Acinus, Atrophy | 1 |
Acinus, Fibrosis | 3 |
Acinus, Focal Cellular Change | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 1 |
Duct, Hyperplasia | 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 3 3 |
Inflammation, Suppurative | 3 |
Ulcer | 1 3 3 1 2 |
Epithelium, Hyperplasia | 3 2 1 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 2 1 1 2|
Inflammation, Suppurative | |
Mineralization | |
Necrosis | 1 |
Atrium, Congestion | 4 3 |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + M + A + + + + +|
Degeneration, Fatty | 2 2 1 2 2 1 2|
Focal Cellular Change | 1 |
Hematopoietic Cell Proliferation | 4 2|
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + A I + I + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + A M M I + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + +|
Degeneration, Cystic | 3 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A A + + A + +|
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + M + + + M M|
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + A + + + + + + + + +|
Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 1 1 |
Proliferation | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Submucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + A + + + + + + + + +|
Mesenteric, Inflammation, Focal, | |
Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + M + + + + + + + + +|
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + A + + + + + +|
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 4 2|
Inflammation, Granulomatous | |
Pigmentation, Hemosiderin | 2 2 |
Capsule, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Thymus | + + M + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + +|
Acanthosis | |
Ulcer | 3 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + A + +|
Inflammation, Suppurative | 1 1 1 1 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic, Focal | 2 1 |
Inflammation, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia | 2 3 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation | 1 1 1 1 1 1 2 2 1 1 2 1 |
Inflammation, Suppurative | 1 1 1 1 2 1 1 2 1 1 1 1 1 3 1 1 1 |
Thrombosis | 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 1 2 2|
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Synechia | 2 |
Lens, Degeneration | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lacrimal Gland | + + |
Inflammation, Suppurative | 1 |
Acinus, Atrophy | 2 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|
| 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Nephropathy | 1 2 2 1 3 1 2 1 1 3 2 1 2 2 4 2|
Artery, Hyperplasia | 2 |
Capsule, Inflammation | 1 |
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A I + | 20 |
Inflammation, Suppurative | 1 | 1 1.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + A + + | 20 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 23 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + I + + + + + + | 24 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | I + I + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | I I + I + + + + + A A A | 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 2 | 6 2.0|
Basophilic Focus | 1 1 1 1 1 2 1 1| 18 1.3|
Clear Cell Focus | 1 1 | 2 1.0|
Degeneration, Fatty | 2 2 3 2 2 2 2 2 3| 19 2.2|
Hematopoietic Cell Proliferation | 1 1 1 | 5 1.4|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia | 2 | 3 2.7|
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 2 1 1 1 2 | 23 1.4|
Leukocytosis | | 1 1.0|
Necrosis | 2 1 1 2 1 1| 13 1.5|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 2 | 10 1.4|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Inflammation, Chronic | 3 3 | 3 3.0|
Fat, Necrosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + | 25 |
Acinus, Atrophy | 1 1 | 3 1.0|
Acinus, Fibrosis | | 1 3.0|
Acinus, Focal Cellular Change | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + M + + + + + + | 25 |
Inflammation, Suppurative | | 1 1.0|
Duct, Hyperplasia | 2 1 | 8 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 2 3 3 2 | 9 2.6|
Inflammation, Suppurative | 2 | 2 2.5|
Ulcer | 1 2 4 3 3 | 10 2.3|
Epithelium, Hyperplasia | 3 2 2 3 3 | 10 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + +| 31 |
Inflammation, Chronic | 1 2 1 2 | 4 1.5|
Inflammation, Suppurative | 1| 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Ulcer | 3 2 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 28 |
Cardiomyopathy | 1 1 1 1 1 2 2 1 1 1 | 21 1.2|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | | 1 1.0|
Atrium, Congestion | | 2 3.5|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + A + + | 26 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + | 25 |
Degeneration, Fatty | 2 3 2 2 2 | 12 1.9|
Focal Cellular Change | 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 2 | 4 2.3|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + I M + + + A + + | 21 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + A + + | 24 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + + + + + | 22 |
Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| 44 |
Degeneration, Cystic | 3 2 | 3 2.7|
Pars Distalis, Angiectasis | 3 | 2 2.5|
Pars Distalis, Hemorrhage | 1 2 | 2 1.5|
Pars Distalis, Hyperplasia | 3 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + +| 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 3 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 25 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 2 2.0|
Cyst | 3 | 3 1.7|
Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + | 31 |
Submucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 26 |
Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Mesenteric, Inflammation, Focal, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + I | 25 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 2 | 4 2.5|
Inflammation, Granulomatous | 2 | 1 2.0|
Pigmentation, Hemosiderin | 2 | 3 2.0|
Capsule, Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + M + + + | 23 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 1 | 3 1.0|
Hyperplasia | 1 1 2 2 1 | 9 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + +| 33 |
Acanthosis | 2 | 1 2.0|
Ulcer | | 2 3.5|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 29 |
Fibrous Osteodystrophy | 1 | 1 1.0|
Osteopetrosis | 3 2| 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 28 |
Hemorrhage | 1 2 | 4 1.8|
Hydrocephalus | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + | 24 |
Inflammation, Suppurative | 1 1 1 1 2 | 10 1.2|
Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 4 2.8|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 1 1 1 | 7 1.1|
Inflammation, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 4 | 4 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 | 4 1.5|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 1 1 1 1 2 1 1 | 21 1.2|
Inflammation, Suppurative | 1 1 1 1 2 1 2 1 1 1 1 1 1| 30 1.2|
Thrombosis | 2 2 1| 5 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 3 1 2 1 2 2 | 13 1.7|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5| |
| 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.0|
Vomeronasal Organ, Inflammation, | | |
Suppurative | | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + I + + | 25 |
Inflammation, Suppurative | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Synechia | 3 | 2 2.5|
Lens, Degeneration | 4 3 | 3 3.3|
Retina, Degeneration | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 3 |
Inflammation, Suppurative | | 1 1.0|
Acinus, Atrophy | 2 | 3 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + +| 37 |
Hematopoietic Cell Proliferation | | 1 2.0|
Nephropathy | 3 1 1 3 2 2 2 3 1 1 2 1 2 3 2 4 3 2| 34 2.0|
Artery, Hyperplasia | | 1 2.0|
Capsule, Inflammation | | 1 1.0|
Renal Tubule, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + M + + + + + + | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|
| 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + A A A|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + A A A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + A A A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A A A|
__________________________________________________________________________|
Intestine Small | + A + + + + A A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A A +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + A M + I + A A A|
__________________________________________________________________________|
Intestine Small, Jejunum | I A + + I + A A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 2 3 1 2 1 1 2 X 1 1 1 1 1 |
Congestion | |
Degeneration, Fatty | 1 1 2 |
Hematopoietic Cell Proliferation | 2 1 1 |
Hepatodiaphragmatic Nodule | X X X X X X X|
Inflammation, Focal, Granulomatous | 2 1 1 2 1 1 1 2 1 2 1 1 1 1 |
Necrosis | 1 1 2 2 |
Pigmentation, Bile | |
Bile Duct, Hyperplasia | 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A|
Acinus, Atrophy | 1 1 1 |
__________________________________________________________________________|
Pharynx | + |
Palate, Developmental Malformation | X |
__________________________________________________________________________|
Salivary Glands | + + M + + + M + +|
Inflammation, Suppurative | 1 |
Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Ulcer | 4 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + A + +|
Hemorrhage | |
Inflammation, Suppurative | 2 |
Pigmentation, Hemosiderin | 2|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|
| 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + +|
Degeneration, Fatty | 2 2 3 |
Hematopoietic Cell Proliferation | 2 1 |
Hyperplasia | 2 |
Necrosis | |
Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + I + + + M|
Hyperplasia | 1 4 2 2 2 |
Thrombosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|
| 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 1 |
Inflammation, Focal, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + M + +|
Hyperplasia | 1 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 |
Hematopoietic Cell Proliferation | 1 3 |
Hemorrhage | 3 3|
Necrosis | |
Thrombosis | 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Suppurative | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Hemorrhage | 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + A + A|
Inflammation | 1 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Edema | |
Hemorrhage | 1 1 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Perivascular, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|
| 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mononuclear Cell | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 2 1 1 2 2 2 2 1 1 1 1 1 2 1 2 1 1 |
Inflammation, Suppurative | 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 1 1 1 1 |
Olfactory Epithelium, Degeneration | 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2|
Vomeronasal Organ, Inflammation, | |
Suppurative | 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + A + A|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Suppurative | |
Lens, Degeneration | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Lacrimal Gland | + + + |
Acinus, Atrophy | 2 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Suppurative | |
Mineralization | |
Nephropathy | 2 2 2 1 1 2 3 3 2 1 2 2 2 3 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A A + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + M A + A + I I + | 10 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A A + + + + + + | 15 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M A + + A A + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + + I + A A + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + I + A A + + + + + + | 15 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | I A I + A A A A A I I I | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | I + I + A A I I + A A + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 1 1 1 | 6 1.3|
Basophilic Focus | 1 2 1 1 1 1 1 1 1 1 1| 24 1.3|
Congestion | 3 | 1 3.0|
Degeneration, Fatty | 3 2 3 2 2 | 8 2.0|
Hematopoietic Cell Proliferation | 2 1 1 3 1 1 | 9 1.4|
Hepatodiaphragmatic Nodule | X | 8 |
Inflammation, Focal, Granulomatous | 1 1 1 1 2 1 1 1 2 1 1 1| 26 1.2|
Necrosis | 1 2 1 3 1 | 9 1.6|
Pigmentation, Bile | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 2 1 | 6 1.2|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Inflammation, Chronic | 2 | 2 2.5|
Fat, Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + | 19 |
Acinus, Atrophy | 2 2 | 5 1.4|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Developmental Malformation | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 19 |
Inflammation, Suppurative | 1 1 | 3 1.0|
Duct, Hyperplasia | 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 21 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Ulcer | 1 | 2 2.5|
Epithelium, Hyperplasia | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + | 20 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Ulcer | 3 1 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 21 |
Cardiomyopathy | 1 2 1 2 1 1 2 1 | 16 1.3|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + | 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + | 23 |
Degeneration, Fatty | 2 1 1 1 | 7 1.7|
Hematopoietic Cell Proliferation | 2 | 3 1.7|
Hyperplasia | 2 2 | 3 2.0|
Necrosis | 2 | 1 2.0|
Thrombosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + A + M + M + + + | 18 |
Hyperplasia | 1 2 | 7 2.0|
Thrombosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M + + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + A + + + + + + + + + + + + + + | 42 |
Degeneration, Cystic | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 3 3 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + A + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + | 21 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 3 1 | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 23 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + | 19 |
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Hyperplasia | 1 1| 3 1.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + | 19 |
Hyperplasia | 1 | 2 1.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 | 3 1.3|
Hematopoietic Cell Proliferation | 2 4 4 1 2 | 7 2.4|
Hemorrhage | 3 | 3 3.0|
Necrosis | 3 | 1 3.0|
Thrombosis | 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + | 20 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 30 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Suppurative | | 1 1.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 21 |
Osteopetrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 21 |
Hemorrhage | 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + A + + + + + + + | 18 |
Inflammation | 2 | 2 1.5|
Inflammation, Suppurative | 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 3 | 5 3.0|
Edema | 3 | 1 3.0|
Hemorrhage | 2 | 3 1.3|
Infiltration Cellular, Mixed Cell | 2 3 | 2 2.5|
Inflammation, Chronic, Focal | 1 2 2 1 1 1 1 1 1| 24 1.1|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 1 1 | 5 1.2|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 2 1 1 1 1 1 | 21 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 1 1 2 2 1 1 2 1 1 2 1 2 1| 34 1.4|
Inflammation, Suppurative | 1 1 2 2 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| 43 1.1|
Thrombosis | 1 1 3 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 2 1 1 1 | 11 1.2|
Olfactory Epithelium, Degeneration | | 1 1.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 1 2 1 2 1 | 6 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 2 2 | 5 1.6|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + A + + + + + + + | 18 |
Inflammation, Suppurative | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cornea, Inflammation, Suppurative | 2 | 1 2.0|
Lens, Degeneration | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + + + + | 7 |
Acinus, Atrophy | 2 2 2 2 | 7 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5| |
| 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + + | 30 |
Cyst | X | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Nephropathy | 2 1 3 2 2 1 2 3 3 1 2 2 2 2 | 29 2.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + + + + + | 20 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | M M + M M + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + I + + + + + + + I + + + + + I + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + I + + + + A + + + + + + + + + A A + + + A + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 2 |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | |
Congestion | |
Degeneration, Fatty | 2 2 1 2 1 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Focal, Granulomatous | 1 1 1 1 2 1 2 1 1 1 1 2 1 1|
Leukocytosis | |
Necrosis | 1 1 1 2 1|
Thrombosis | |
Bile Duct, Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 1 1 1 |
Acinus, Inflammation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1|
Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 |
Inflammation, Suppurative | 2 |
Ulcer | 3 3 2 |
Epithelium, Hyperplasia | 3 2 2 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 1|
Pigmentation, Hemosiderin | |
Ulcer | 2 1|
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 3 1 2 2 1 2 2 1 2 2 3 2 1 1 1 2 2 1 2 1 2|
Atrium, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 2 2 3 1 1 2 1 2 2 1 1 1 1 4 2 1|
Ectopic Tissue | |
Focal Cellular Change | 1 2 1 1 |
Hematopoietic Cell Proliferation | 1 2 2 1 1 1 |
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M M I|
Hyperplasia | 3 3 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + M + + + + + + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 |
Hyperplasia | 3 |
Inflammation, Suppurative | 2 1 1 1 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Cyst | 4 1|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | 4 |
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Hyperplasia, Neutrophil | 3 |
Myelofibrosis | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + M M + + M +|
Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + M + + + + + + +|
Congestion | 2 |
Hyperplasia | 3 1 2 1 2 2 1 1 1 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 3 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Degeneration, Cystic | 3 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 1 4 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 2 4 |
Periosteum, Proliferation | 1 1 1 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hydrocephalus | |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 2 1 1 1 1 2 1 1 2 1|
Metaplasia, Squamous | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 1 2 1|
Inflammation, Chronic, Focal | 1 1 1 1 1 1 2 1 2 2 1 1 1 1 1 1 1 1|
Inflammation, Focal, Granulomatous | |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 1 1 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 2 1 1 2 1 1 1 1 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 2 1 2 1 1 1 2 2 2 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 2 2 3 2 4 2 3 3 4 2 2 2 3 3 3 2 1 2 3 2 3 2 1|
Inflammation, Suppurative | 1 2 1 1 1 1 2 2 1 1 1 2 1 1 2 1 2 2 1 1 2 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 1 2 1 1 |
Olfactory Epithelium, Degeneration | 1 2 1 2 2 1 1 1 2 2 3 2 2|
Olfactory Epithelium, Metaplasia | 1 1 2 1 2 3 1 2|
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 1 |
Respiratory Epithelium, Hyperplasia | 2 2 2 2 3 2 3 2 2 3 2 2 2 2 2 3 2 2 2 3 2 3 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 3 3 3 4 2 4 3 3 3 3 4 3 4 4 3 3 4 4 3 3 3 3 3 4|
Submucosa, Hyperplasia | 2 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 1 1 1 2 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Synechia | 3 |
Cornea, Hyperplasia | 2 |
Cornea, Inflammation, Suppurative | 4 |
Lens, Degeneration | 4 |
Lens, Mineralization | 2 |
Retina, Degeneration | 4 2 3|
__________________________________________________________________________|
Harderian Gland | |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lacrimal Gland | + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|
DAY ON TEST | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|
| 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Acinus, Atrophy | 2 2 2 2|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 2 3 1 2 2 1 2 3 2 1 2 2 2 2 2 2 2 2 3 2 3|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | M + M + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
Vein, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + A A + + + + + + + + A +| 46 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + M + + + + + A| 47 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + M + M + + + + +| 43 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + I + + + A + + I + + A A + + A + + + + + A A| 40 |
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + + + A + + + + + A + + + + + + + + + A A| 38 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 | 7 1.4|
Basophilic Focus | 1 1 1 2 1 1 1 1 1 1 1 | 22 1.0|
Clear Cell Focus | 1 | 1 1.0|
Congestion | 3 | 1 3.0|
Degeneration, Fatty | 2 2 1 1 2 1| 11 1.5|
Eosinophilic Focus | 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X X X X X | 11 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 2 1 1 1 2 1 1 1| 28 1.2|
Leukocytosis | 2 | 1 2.0|
Necrosis | 1 2 2 1 | 9 1.3|
Thrombosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 1 1 1 1 | 10 1.3|
Acinus, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 | 13 1.0|
Duct, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 25 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
Ulcer | 2 2 | 5 2.4|
Epithelium, Hyperplasia | 4 3 2 | 7 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Ulcer | 3 | 3 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 1 2 2 1 2 1 2 2 1 1 1 2 1 1 2 2 3 2 2 2| 49 1.7|
Atrium, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + A +| 48 |
Degeneration, Fatty | 1 1 2 1 1 1 2 2 3 1 1 1 | 29 1.6|
Ectopic Tissue | X | 1 |
Focal Cellular Change | 1 1 1 1 | 8 1.1|
Hematopoietic Cell Proliferation | 1 1 2 1 | 10 1.3|
Hyperplasia | 1 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + I + + + + + + + + + A + + + + + + + + + A +| 44 |
Hyperplasia | 2 1 2 1 | 8 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + M + + + M + + + + + + I| 43 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 3 3 2 3 3 1| 7 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Cyst | | 2 1.5|
Hyperplasia | 4 | 2 3.5|
Inflammation, Suppurative | 1 2 2 | 7 1.4|
Duct, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 | 4 2.0|
Cyst | 2 1 1 1 | 6 1.7|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 | 2 2.0|
Hemorrhage | 3 | 2 3.5|
Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Depletion Cellular | | 1 3.0|
Hyperplasia, Neutrophil | 2 | 2 2.5|
Myelofibrosis | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + M + +| 46 |
Hyperplasia | 1 1 1 1 1 | 10 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Congestion | | 1 2.0|
Hyperplasia | 2 2 2 1 1 2 1 2 | 19 1.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 2 | 5 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Granulomatous | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + M + + + + + + + + + + + + + + + +| 47 |
Degeneration, Cystic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | 1 | 1 1.0|
Hyperplasia | 2 2 2 1 1 2 1 | 11 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Epidermis, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 2 2 2 | 6 2.3|
Periosteum, Proliferation | 1 1 1 1 1 1 1 1 2 1 | 18 1.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 | 3 2.3|
Hydrocephalus | 1 | 1 1.0|
Necrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 1 2 1 2 1 2 1 1 | 22 1.3|
Metaplasia, Squamous | 1 | 2 1.5|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 4 | 3 3.3|
Hemorrhage | 2 1 1 1 | 8 1.4|
Inflammation, Chronic, Focal | 1 1 2 2 2 1 1 1 1 2 2 2 2 1 | 32 1.3|
Inflammation, Focal, Granulomatous | 1 1 | 2 1.0|
Inflammation, Suppurative | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 3 2 | 5 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 20 1.1|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 2 1 1 1 1 1 1 | 23 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 2 2 3 2 4 2 2 2 2 2 2 2 2 2 2 3 3 2 2 3 2 1| 48 2.3|
Inflammation, Suppurative | 1 1 1 2 1 2 1 1 1 1 2 2 2 1 1 2 2 2 1 1 2 2 1 | 47 1.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 | 7 1.6|
Olfactory Epithelium, Degeneration | 2 2 2 1 1 3 1 2 1 2 | 23 1.7|
Olfactory Epithelium, Metaplasia | 1 2 2 1 1 2 1 | 15 1.5|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 3 | 3 2.0|
Respiratory Epithelium, Hyperplasia | 2 3 3 1 2 1 2 2 2 2 2 1 1 2 2 3 3 2 1 3 2 2 3| 46 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3| |
| 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Metaplasia, | | |
Squamous | 4 3 3 1 3 1 4 4 3 3 3 3 3 4 3 4 4 3 3 1 2 2 3 3| 49 3.1|
Submucosa, Hyperplasia | 1 1 1 | 5 1.2|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 1 1 1 | 12 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + I +| 48 |
Inflammation, Suppurative | 1 | 3 1.0|
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Synechia | 3 1 | 3 2.3|
Cornea, Hyperplasia | | 1 2.0|
Cornea, Inflammation, Suppurative | 1 1| 3 2.0|
Lens, Degeneration | 4 2 1 3 | 5 2.8|
Lens, Mineralization | 3 | 2 2.5|
Retina, Degeneration | 3 1 2 | 6 2.5|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Metaplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + + + | 7 |
Acinus, Atrophy | 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | +| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 3 2 2 1 2 2 2 2 2 3 1 2 2 2 2 2 2 2 1 2 2 2 1 1| 48 1.9|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
Vein, Ectasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + I + + + + + I + + + + + + I + + A + + + A + + +|
Hemorrhage | |
Inflammation, Suppurative | 1 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + A + + + A + + +|
Inflammation, Suppurative | 3 |
Parasite Metazoan | X X X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + I + A + A + + + A + + +|
Hyperplasia, Lymphoid | 2|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + I + + + + + + + + A + A + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Basophilic Focus | 1 1 1 1 1 2|
Clear Cell Focus | X 3 3 1 |
Degeneration, Cystic | 1 |
Degeneration, Fatty | 1 3 3 3 1 2 4 4 3 |
Degeneration | 2 3 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 |
Leukocytosis | |
Necrosis | 2 1 3 2 2 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 2 1 2 1 2 1 2 1 1 1 1 1 2 1 3 2 1 2 2 1 1|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 3 1 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Acinus, Atrophy | 1 1 2 2 2 1 2 1 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1|
Duct, Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 4 3 2 3 2 3|
Inflammation, Suppurative | 1 |
Ulcer | 3 2 3 3 2 2 1|
Epithelium, Hyperplasia | 4 3 3 3 3 4|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Eosinophil | |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 1 2 3 2 2 2 |
Mineralization | 4 4 3 |
Ulcer | 3 1 3 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
Mineralization | 3 3 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 3 3 2 3 2 2 2 1 2 2 1 2 2 1 2 2 2 2 2 2 3 3|
Mineralization | 2 |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 2 2 2 1 2 1 1 2|
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 3 1 |
Hypertrophy | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 1 4 2 2 2 2 3 2 1 |
Necrosis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + M M + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 2 2 3 |
Pars Distalis, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + I + + + +|
C-Cell, Hyperplasia | 1 3 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Suppurative | 1 1 2 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 3 2 1 1 2 2 3 1 3 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Inflammation, Suppurative | 3 1 1 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 4 1 3 4 4 4 4|
Necrosis | |
Interstitial Cell, Hyperplasia | 1 1 1 |
Perivascular, Inflammation | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 2 |
Hyperplasia, Neutrophil | |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Mesenteric, Inflammation, Focal, | |
Granulomatous | 3 |
Mesenteric, Pigmentation, Hemosiderin| 2 |
Renal, Congestion | 3 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Focal, Granulomatous | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis | 2 4 |
__________________________________________________________________________|
Thymus | M + + + M + + + M M + + M + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M + + M + + M + M M M M + + + M + + M +|
Galactocele | 1 1 1 1 2 |
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 3 3 |
Periosteum, Proliferation | 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Suppurative | |
Meninges, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 2 1 1 2|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 1 |
Inflammation, Chronic, Focal | 1 2 1 1 |
Inflammation, Focal, Granulomatous | 1 |
Mineralization | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 |
Peribronchial, Infiltration Cellular,| |
Mononuclear Cell | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 1 1 3 2 1 1 2 2 2 1|
Inflammation, Suppurative | 2 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1|
Thrombosis | 3 3 2 1 2 2 4 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 3 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|
DAY ON TEST | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|
| 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Degeneration | 2 |
Olfactory Epithelium, Metaplasia | 2 1 |
Respiratory Epithelium, Hyperplasia | 2 1 1 1 3 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + I + + + + + + +|
Inflammation, Suppurative | 1 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Inflammation, | |
Suppurative | 2 1 |
Cornea, Degeneration | 2 |
Cornea, Inflammation, Suppurative | |
Cornea, Mineralization | 2 1 |
Lens, Degeneration | 2 1 |
Lids, Inflammation, Suppurative | 1 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + |
Inflammation, Suppurative | 1 1 1 1 1 |
Metaplasia, Squamous | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Zymbal's Gland | + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Mineralization | 3 |
Nephropathy | 2 3 3 4 3 3 4 2 2 3 1 3 2 2 2 2 3 2 4 3 3 2 4 4 3|
Pelvis, Epithelium, Hyperplasia | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Suppurative | 2 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 44 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 2 2.0|
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + I + + + + + + + + + + +| 45 |
Inflammation, Suppurative | | 1 3.0|
Parasite Metazoan | | 3 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + I + A + + A + + + +| 42 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 | 9 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A A + A + + A + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 | 3 1.7|
Basophilic Focus | 1 1 2 1 1 1 1 1 1 1 2 | 17 1.2|
Clear Cell Focus | 2 1 2 1 3 | 9 2.0|
Degeneration, Cystic | | 1 1.0|
Degeneration, Fatty | 2 1 1 2 3 3 3| 16 2.4|
Degeneration | | 3 2.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X | 7 |
Inflammation, Focal, Granulomatous | 2 1 2 1 1 2 1 1 1 | 14 1.2|
Leukocytosis | 1 1 1 2 X | 5 1.3|
Necrosis | 1 2 1 | 8 1.8|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 3 1 1 2 2 1 1 1 1 1| 40 1.4|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Inflammation, Chronic | 3 | 2 3.0|
Fat, Necrosis | 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Acinus, Atrophy | 1 1 1 3 3 1 1 1 1 2 1 1 | 22 1.5|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1 1 1 | 12 1.0|
Duct, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 | 15 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 4 2 2 2 3 2| 13 2.6|
Inflammation, Suppurative | | 1 1.0|
Ulcer | 2 4 3 1 3| 12 2.4|
Epithelium, Hyperplasia | 2 3 1 2 4 4 1| 13 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Eosinophil | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 2 | 8 2.0|
Mineralization | 2 | 4 3.3|
Ulcer | 2 3 | 8 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
Mineralization | | 3 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 2 2 2 3 3 2 2 2 2 1 2 2 2 2 2 1 3 2 1| 47 2.0|
Mineralization | | 1 2.0|
Atrium, Thrombosis | 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 1 2 2 1 2 2 1 2 2 2 | 22 1.7|
Focal Cellular Change | 1 1 1 | 3 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 | 6 1.0|
Hyperplasia | 2 2 | 4 2.0|
Hypertrophy | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + I M + + + + + M + M M| 42 |
Hyperplasia | 3 1 2 2 3 | 15 2.1|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | I + + + + + + + + + + + + + + + M + + + + M + M I| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hemorrhage | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 4 2 4 2 4 2 2 4 | 12 2.8|
Pars Distalis, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
C-Cell, Hyperplasia | 1 1 4 2 1 | 8 1.9|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 3.0|
Inflammation, Suppurative | 2 1 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 1 1 1| 6 1.2|
Inflammation, Suppurative | 2 1 3 3 1 1 1 1 1 1 1 1 | 23 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 7 |
Inflammation, Suppurative | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 4 4 2 | 14 3.2|
Necrosis | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 1 | 6 1.0|
Perivascular, Inflammation | 1 2 2 | 5 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | | 1 2.0|
Hyperplasia, Neutrophil | 3 | 1 3.0|
Myelofibrosis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mesenteric, Inflammation, Focal, | | |
Granulomatous | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Pigmentation, Hemosiderin| | 1 2.0|
Renal, Congestion | | 1 3.0|
Renal, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 2 | 5 1.8|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + + + +| 47 |
Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 | 21 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectopic Tissue | X | 1 |
Fibrosis | 2 | 3 2.3|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis | 2 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + M + M + + + M M + + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M + + M + M M + M M M M M M + M M + + M| 21 |
Galactocele | 1 2 | 7 1.3|
Hyperplasia | 1 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | X | 5 2.5|
Periosteum, Proliferation | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Meninges, Pigmentation, Hemosiderin | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Inflammation, Suppurative | 2 1 1 2 2 1 1 1 1 1| 22 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage | 1 | 3 1.0|
Inflammation, Chronic, Focal | 2 1 2 1 2 1 1 2 3| 13 1.5|
Inflammation, Focal, Granulomatous | | 1 1.0|
Mineralization | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 2 1 2 | 5 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 1.7|
Peribronchial, Infiltration Cellular,| | |
Mononuclear Cell | 2 | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 2 1 1 2 2 1 1 2 3 1 | 18 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 1 3 3 2 1 1 1 1 1 1 2 2 2 2 2 | 28 1.7|
Inflammation, Suppurative | 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.2|
Thrombosis | 1 3 1 | 11 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2 2 2 2 2 1 1| 17 1.8|
Olfactory Epithelium, Degeneration | | 1 2.0|
Olfactory Epithelium, Metaplasia | | 2 1.5|
Respiratory Epithelium, Hyperplasia | 2 1 1 1 1 1 | 12 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 4 1.0|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 2 1.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Anterior Chamber, Inflammation, | | |
Suppurative | 3 | 3 2.0|
Cornea, Degeneration | | 1 2.0|
Cornea, Inflammation, Suppurative | 2 3 | 2 2.5|
Cornea, Mineralization | | 2 1.5|
Lens, Degeneration | 3 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2| |
| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lids, Inflammation, Suppurative | | 1 1.0|
Retina, Degeneration | 2 | 2 2.5|
__________________________________________________________________________|____________|
Harderian Gland | +| 7 |
Inflammation, Suppurative | | 5 1.0|
Metaplasia, Squamous | 1| 1 1.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Mineralization | | 1 3.0|
Nephropathy | 3 3 3 3 3 2 3 2 1 4 3 3 1 3 3 2 2 1 3 3 2 3 3 3 1| 50 2.6|
Pelvis, Epithelium, Hyperplasia | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + A + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + A M + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + I + + + + + I + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + A + A + + + + A + + I|
__________________________________________________________________________|
Intestine Small, Jejunum | A + A + A + A + + + + A + A I|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | 1 1 X 1 |
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 1 1 |
Degeneration, Fatty | 1 2 1 1 1 2 1 2 2 1 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Focal, Granulomatous | 1 1 1 1 2 1 |
Leukocytosis | |
Necrosis | 1 1 2 1 1 1 |
Bile Duct, Hyperplasia | 1 1 2 2 2 1 2 1 2 2 2 2 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic | 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 1 1 |
__________________________________________________________________________|
Pharynx | |
Palate, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
Duct, Hyperplasia | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 4 2 2|
Ulcer | 1 4 4 1|
Epithelium, Hyperplasia | 3 4 3 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + +|
Hemorrhage | |
Inflammation, Chronic | 2 3 |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | 2 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 1 3 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 1 2 1 3 2 2 3 1 2 2|
Atrium, Congestion | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 1 1 1 2 1 1 2 1 3 1 1 1 1|
Focal Cellular Change | 1 |
Hematopoietic Cell Proliferation | 2 1 1 |
Hyperplasia | 1 |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + M + + M + + + +|
Hyperplasia | 2 1 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation, Suppurative | 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 3 1 2 1 1 2 1 2 2 1 4|
__________________________________________________________________________|
Seminal Vesicle | + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 4 2 3 3 4|
Interstitial Cell, Hyperplasia | 1 2 1 1 |
Perivascular, Inflammation | 2 2 |
Tunic, Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mesenteric, Angiectasis | |
Mesenteric, Inflammation, Focal, | |
Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + I M + + M + + + + + M + M|
Hyperplasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Fibrosis | 2 2 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | 4|
Necrosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | I + + + M + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M + + M M M M M M|
Galactocele | 4 X |
Hyperplasia | |
Inflammation, Chronic | 4 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Periosteum, Proliferation | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | A + + + + + + + + + + A + + +|
Inflammation, Suppurative | 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + A + + +|
Congestion | 3 |
Hemorrhage | |
Inflammation, Chronic, Focal | 1 2 1 1 1|
Alveolar Epithelium, Hyperplasia | 3 2 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 1|
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Adenomatous | 4 |
Inflammation | 2 1 2 2 1 1 1 1 1 2 |
Inflammation, Suppurative | 1 1 1 1 1 2 1 2 2 1 1 1 1 1 1 2 1 1 1 2 2 1 1|
Thrombosis | 2 1 2 1 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 2 1 1 1 |
Olfactory Epithelium, Degeneration | 1 |
Olfactory Epithelium, Metaplasia | 1 2 |
Respiratory Epithelium, Hyperplasia | 1 2 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Vomeronasal Organ, Inflammation, | |
Suppurative | 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + A + + +|
Inflammation, Suppurative | 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Anterior Chamber, Inflammation, | |
Suppurative | |
Cornea, Inflammation, Suppurative | 2 |
Lens, Degeneration | 3 4 |
Retina, Degeneration | 3 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 2 |
Inflammation, Suppurative | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|
| 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
.075 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 3 2 2 2 3 3 1 4 3 3 2 2 4 2 1 2 2 4 2 3|
Pigmentation, Hemosiderin | |
Pelvis, Epithelium, Hyperplasia | |
Renal Tubule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + +|
Inflammation | |
Inflammation, Suppurative | 1 2 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + M + + + + I + + + + + I + +| 26 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + M + + + + + + + + + + +| 32 |
Parasite Metazoan | X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + +| 30 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + I + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + I + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A A M I + + + I + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + M + A A + + + I + A + + + A A A| 18 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 1 2 | 5 1.6|
Basophilic Focus | 2 1 2 | 7 1.3|
Clear Cell Focus | 1 | 2 1.0|
Degeneration, Cystic | 2 1 2 1 | 7 1.4|
Degeneration, Fatty | 1 2 1 1 1 1 1 3 3 2 2 1 1| 24 1.5|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Focal, Granulomatous | 1 1 2 1 2 1 1 | 13 1.2|
Leukocytosis | 2 | 1 2.0|
Necrosis | 2 2 1 2 | 10 1.4|
Bile Duct, Hyperplasia | 2 1 1 1 1 2 2 2 1 2 2 2 1 1 2 1 1 1 2| 32 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 33 |
Acinus, Atrophy | 1 2 2 1 | 10 1.4|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Suppurative | 1 1 1 1| 6 1.0|
Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 16 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 33 |
Inflammation, Chronic | 3 3 2 2 | 9 2.6|
Ulcer | 3 3 2 | 7 2.6|
Epithelium, Hyperplasia | 3 3 3 2 2 1 | 11 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 32 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 1 3 2 | 5 2.2|
Inflammation, Suppurative | 1 2 2 1 | 4 1.5|
Pigmentation, Hemosiderin | 1 | 3 1.3|
Ulcer | 1 2 1 3 2 3 2 | 9 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + +| 35 |
Cardiomyopathy | 2 2 2 2 2 1 2 2 1 2 1 2 2 1 2 3 2 1| 34 1.8|
Atrium, Congestion | | 1 2.0|
Atrium, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 1 3 1 1 1 2 2 1 2 1 1 | 26 1.4|
Focal Cellular Change | | 1 1.0|
Hematopoietic Cell Proliferation | 2 1 | 5 1.4|
Hyperplasia | 2 4 | 3 2.3|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 3 2 2 2 1 2 4 1 1 2 2 2 2 1| 19 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 36 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +| 32 |
Hyperplasia | 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 43 |
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 1 2 | 5 1.2|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + M + + +| 32 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Inflammation, Suppurative | 2 2 4 1 1 | 8 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + +| 34 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Suppurative | 2 3 1 1 3 2 3 3 1 2| 21 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
Dilatation | 3 | 2 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 3 3 4 3 3 2 4| 14 3.1|
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 | 10 1.2|
Perivascular, Inflammation | | 2 2.0|
Tunic, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 33 |
Myelofibrosis | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 35 |
Mediastinal, Congestion | 4 | 1 4.0|
Mesenteric, Angiectasis | 2 | 1 2.0|
Mesenteric, Inflammation, Focal, | | |
Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + M + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + +| 27 |
Hyperplasia | 2 2 2 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 2 2 | 6 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
Necrosis | 2 | 1 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + M M + + + + + + + + + + + M| 26 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M + + M M + + + M +| 10 |
Galactocele | 1 1 1 1| 6 1.6|
Hyperplasia | 4 | 1 4.0|
Inflammation, Chronic | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + +| 32 |
Epidermis, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 33 |
Fibrous Osteodystrophy | 1 1 | 2 1.0|
Periosteum, Proliferation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 33 |
Hemorrhage | 2 | 2 2.5|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | A + + + + + + + + + + + + + + + + +| 30 |
Inflammation, Suppurative | 1 2 1 2 1 1 1 1 1 1 2| 19 1.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 2 3.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 1 3 1 2 2| 11 1.5|
Alveolar Epithelium, Hyperplasia | 1 1| 5 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 4 2 2 1| 9 2.1|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 | 12 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Adenomatous | | 1 4.0|
Inflammation | 1 2 1 2 1 3 2 1 1 | 19 1.5|
Inflammation, Suppurative | 1 2 2 1 2 2 1 1 2 1 2 1 2 1 1 1 2 1 1 1 1 2| 45 1.3|
Thrombosis | 1 3 3 3 3| 10 2.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 1 1 2 1 2| 14 1.4|
Olfactory Epithelium, Degeneration | 2 1 2 | 4 1.5|
Olfactory Epithelium, Metaplasia | 2 2 | 4 1.8|
Respiratory Epithelium, Hyperplasia | 1 1 1 2 1 1 1 | 11 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 2 2 1| 5 1.4|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 1 1 2 | 7 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6| |
DAY ON TEST | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9| |
| 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
.075 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | A + + + + + + I + + + + + + + + + I| 29 |
Inflammation, Suppurative | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Anterior Chamber, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Cornea, Inflammation, Suppurative | 1 3 | 3 2.0|
Lens, Degeneration | 3 | 3 3.3|
Retina, Degeneration | 3 | 3 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Hydronephrosis | 1 | 1 1.0|
Infarct | | 1 2.0|
Inflammation, Suppurative | 2 1 | 2 1.5|
Mineralization | 2 | 1 2.0|
Nephropathy | 2 2 2 2 4 1 3 4 2 4 3 2 3 3 1 3 3 2 1 2 3 1| 43 2.4|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Pelvis, Epithelium, Hyperplasia | 2 1 | 2 1.5|
Renal Tubule, Hyperplasia | 1 2 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + I + + + + + + + +| 31 |
Inflammation | 2 | 1 2.0|
Inflammation, Suppurative | 1 | 3 1.3|
Transitional Epithelium, Hyperplasia | 1 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + M + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | I + + + + + M + + I + + + A +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + A I|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + I + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + A + + I + + + A I|
__________________________________________________________________________|
Intestine Small, Jejunum | A A A A + + A I + I + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 2 1 |
Basophilic Focus | 2 1 2 1 1 1 |
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 1 |
Degeneration, Fatty | 2 1 2 2 2 1|
Degeneration | 2 |
Hematopoietic Cell Proliferation | 1 2 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 1 1 |
Inflammation, Focal, Granulomatous | 2 1 1 1 1 |
Leukocytosis | |
Necrosis | 2 1 2|
Bile Duct, Hyperplasia | 1 1 1 1 2 2 1 2 2 2 1 1 1 2 2 2|
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Fat, Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + M + A + + + + + +|
Thrombosis | 2 |
Acinus, Atrophy | 2 3 1 1 1 |
__________________________________________________________________________|
Pharynx | |
Palate, Inflammation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + A + + + + + +|
Inflammation, Suppurative | 1 1 1 |
Duct, Hyperplasia | 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Mineralization | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + +|
Ectopic Tissue | |
Inflammation, Chronic | |
Mineralization | |
Pigmentation, Hemosiderin | |
Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 1 2 1 1 2 2 2 2 1 1 2 2|
Mineralization | |
Atrium, Congestion | |
Atrium, Thrombosis | 3 2 1|
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Degeneration, Fatty | 2 1 2 1 1 1 1 1 1 1 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | 1 1 1 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + I + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 2 1 3 1 2 1 3 2 2 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + A + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + A + + + + + +|
Hyperplasia | 2 |
Thrombosis | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 4 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + A + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst | |
Inflammation, Suppurative | 2 1 1 1 1 1 1 2|
__________________________________________________________________________|
Prostate | + + + + + + + + A + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 2 1 3 2 2 2 3 1 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 3 1 3 1 1 4 |
Interstitial Cell, Hyperplasia | 1 3 3 1 1 |
Perivascular, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + +|
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + A + + + + + +|
Hyperplasia | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 4 2 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Granulomatous | |
Necrosis | 1 |
__________________________________________________________________________|
Thymus | + + + M + + + + A M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + + + M M M M + M M|
Galactocele | |
Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X|
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + A + A + + + + + +|
Inflammation | 2 |
Inflammation, Suppurative | 1 1 2 2 1 2 2|
Metaplasia, Squamous | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 1 1 2 1 1 2 1 3 |
Mineralization | |
Pigmentation, Hemosiderin | 3|
Alveolar Epithelium, Hyperplasia | 1 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 3 1 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 2 1 1 1 1 1 1 2 1 2|
Inflammation, Suppurative | 1 1 1 2 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2|
Thrombosis | 3 2 3 3 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 1 1 2|
Olfactory Epithelium, Degeneration | 2 1 |
Olfactory Epithelium, Metaplasia | 1 1 1 2|
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Hyperplasia | 1 2 2 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 1 1 1 1 3|
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|
DAY ON TEST | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|
| 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.25 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Synechia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + +|
Cyst | X X |
Hemorrhage | 4 |
Inflammation, Suppurative | 2 |
Mineralization | |
Nephropathy | 2 4 2 2 2 2 3 4 1 3 2 4 2 4 3 2 2 2|
Papilla, Necrosis | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Hemorrhage | 2 |
Inflammation, Suppurative | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + +| 28 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | A A + + + A + + + + A + + +| 24 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + + + A + + + + A + + +| 21 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + + A + + + + A + + +| 24 |
Parasite Metazoan | X| 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A M + + + A + + M M M + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small | A A + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A + + + + + M I + + + + I| 23 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + A + A I I + + + +| 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + I + A A + + I A + I I| 12 |
__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 1 | 8 1.3|
Basophilic Focus | 1 1 1 X | 10 1.2|
Clear Cell Focus | 1 1 | 3 1.0|
Degeneration, Cystic | 1 2 1 1 2 | 7 1.4|
Degeneration, Fatty | 1 2 2 2 2 | 11 1.7|
Degeneration | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 1 2 | 5 1.4|
Hepatodiaphragmatic Nodule | X X X X | 7 |
Hyperplasia | | 2 1.0|
Inflammation, Focal, Granulomatous | 1 1 1 | 8 1.1|
Leukocytosis | 1 | 1 1.0|
Necrosis | 2 1 1 1 1 1 1 1| 11 1.3|
Bile Duct, Hyperplasia | 1 1 1 2 1 2 1 1 2 1 1 2 2 1 2| 31 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Hemorrhage | 3 | 1 3.0|
Fat, Inflammation, Chronic | 4 | 1 4.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + +| 26 |
Thrombosis | | 1 2.0|
Acinus, Atrophy | 1 1 1 2| 9 1.4|
__________________________________________________________________________|____________|
Pharynx | + + | 2 |
Palate, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | A + + + + + + + + + + + + +| 27 |
Inflammation, Suppurative | 1 1 | 5 1.0|
Duct, Hyperplasia | 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Stomach | A + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + + + + + + + +| 28 |
Inflammation, Chronic | 2 3 | 3 2.3|
Inflammation, Suppurative | 3 | 1 3.0|
Mineralization | 2 | 1 2.0|
Ulcer | 2 3 | 2 2.5|
Epithelium, Hyperplasia | 2 1 3 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + +| 28 |
Ectopic Tissue | X | 1 |
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Ulcer | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + +| 30 |
Cardiomyopathy | 1 2 1 1 3 3 2 2 2 2 2 2 2 1 1| 30 1.8|
Mineralization | 3 | 1 3.0|
Atrium, Congestion | 3 | 1 3.0|
Atrium, Thrombosis | 3 2 | 5 2.2|
Ventricle, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration, Fatty | 1 2 2 2 1 2 2 2 1 1 1| 21 1.4|
Focal Cellular Change | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 1 | 4 1.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 3 2 3 3 2 2 2 1 2| 20 2.1|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + +| 27 |
Hyperplasia | 4 1 | 3 2.3|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +| 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 1 3 3 3 2 | 9 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
C-Cell, Hyperplasia | 1 1 1 2 3 | 10 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + + I + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + A M + + + + + + + + + + + + + + + + + + + + +| 46 |
Cyst | X| 1 |
Inflammation, Suppurative | 1 1 2 1 1 1 | 14 1.2|
__________________________________________________________________________|____________|
Prostate | A + + + + + + + + + + + + +| 27 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Suppurative | 4 3 1 1 | 14 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 6 |
Dilatation | 3 3 | 2 3.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 4 2 3 3 4 4| 17 2.6|
Interstitial Cell, Hyperplasia | 1 1 2 2 1 1| 11 1.5|
Perivascular, Inflammation | 2 3 1 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | A A + + + + + + + + + + + +| 26 |
Myelofibrosis | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | M A + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + + + + + + + + +| 25 |
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | A + + + + + + + + + + + + +| 28 |
Fibrosis | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 2 1 | 7 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + +| 25 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M + M + + M M +| 12 |
Galactocele | 2 2 | 2 2.0|
Hyperplasia | 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Skin | A + + + + + + + + + + + + +| 30 |
Cyst Epithelial Inclusion | | 1 |
Subcutaneous Tissue, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + +| 29 |
Fibrous Osteodystrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + +| 30 |
Hemorrhage | | 4 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | A + + + + + + + + + A + + +| 25 |
Inflammation | | 1 2.0|
Inflammation, Suppurative | 1 1 1 2 1 1| 13 1.4|
Metaplasia, Squamous | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 4 | 2 3.5|
Edema | 1 | 1 1.0|
Hemorrhage | 1 2 | 3 1.7|
Inflammation, Chronic, Focal | 1 1 2 1 1 1 | 14 1.4|
Mineralization | 2 | 1 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 | 6 1.7|
Perivascular, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5| |
DAY ON TEST | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7| |
| 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.25 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 2 1 1 | 19 1.1|
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 2 3 1 1 1 1 1 2 1 2 | 24 1.4|
Inflammation, Suppurative | 1 1 1 1 1 2 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1 1 1| 46 1.2|
Thrombosis | 3 2 1 2 | 9 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 1 1 2 2 1 2 | 14 1.5|
Olfactory Epithelium, Degeneration | 1 | 3 1.3|
Olfactory Epithelium, Metaplasia | 1 1 2 1 2 2 | 10 1.4|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 2 1 2 1 1 | 12 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 6 1.5|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Trachea | A + + + + + + + + + A + + +| 26 |
Inflammation, Suppurative | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Synechia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + +| 39 |
Cyst | | 2 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | 2 | 2 2.0|
Mineralization | 3 | 1 3.0|
Nephropathy | 4 1 2 2 2 4 1 3 3 4 2 3 2 2 3 2 4 4 2 4 1| 39 2.6|
Papilla, Necrosis | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + + + + +| 27 |
Calculus Gross Observation | X | 1 |
Calculus Micro Observation Only | X | 1 |
Hemorrhage | 3 | 2 2.5|
Inflammation, Suppurative | 4 1 3 1 | 4 2.3|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + + + A + A|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + A|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + M + + + + + + A + M + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + A + A|
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + A + + + A + + + + + A + + + + + + + + A + A|
Parasite Metazoan | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 1 1 2 1 1 1 1 1 |
Clear Cell Focus | 1 1 |
Congestion | |
Degeneration, Cystic | 1 |
Degeneration, Fatty | 1 1 1 3 2 3 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Focal, Granulomatous | 1 1 1 1|
Leukocytosis | 2 |
Necrosis | 2 1 |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Acinus, Atrophy | 3 1 2 1 1 1 |
Acinus, Necrosis | 1 |
__________________________________________________________________________|
Pharynx | + |
Palate, Cyst | |
Palate, Developmental Malformation | 2 |
Palate, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 1 |
Duct, Hyperplasia | 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 4 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Ulcer | 3 4 |
Epithelium, Hyperplasia | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
Mineralization | 2 |
Ulcer | 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 1 2 2 1 2 2 1 2 2 2 3 2 3 2 2 2 2 1 1 1 2 3|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + + + + +|
Degeneration, Fatty | 1 2 1 3 1 2 2 1 2 1 1 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 1 2 1 1 1 1 3 3 |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + I M + M + + + + + + + + M + + + + M M + M + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + M + + + + + + + +|
Hyperplasia | 4 4 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M + M + + I + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + A + + + + + + + M + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 4 2 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + I + I + + M|
__________________________________________________________________________|
Penis | + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Squamous | |
Inflammation, Suppurative | 1 1 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
Inflammation, Suppurative | 2 3 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
Dilatation | |
Inflammation, Suppurative | 1 2 1 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 4 4 4 3 |
Interstitial Cell, Hyperplasia | 1 1 1 1 |
Perivascular, Inflammation | 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + I + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2 2 2 2 3 |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 2 3 |
Inflammation, Granulomatous | |
Metaplasia, Osseous | |
Necrosis | 4 3 |
Thrombosis | 1 |
__________________________________________________________________________|
Thymus | M + + + + + + + M + + + + A M M + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M + + M + M + + M M M + + + + + M + M + M|
Galactocele | 4 1 3 1 2 |
Hyperplasia | 1 1 2 2 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Fibrous Osteodystrophy | 2 |
Periosteum, Proliferation | 1 1 1 1 2 1|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 4 1 |
Hydrocephalus | |
Meninges, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 2 1 1 1 2 |
Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 3 3|
Hemorrhage | 1 2 1 |
Inflammation, Chronic, Focal | 2 2 1|
Alveolar Epithelium, Hyperplasia | 1 3 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 3 1|
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 1 1 2 2 2 2 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation | 2 2 3 3 4 3 2 2 3 3 3 3 2 3 3 2 3 1 3 4 3 3 3|
Inflammation, Suppurative | 2 1 1 1 2 2 1 2 2 2 2 2 1 2 2 2 2 1 1 2 2 2 1|
Thrombosis | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 1 2 2 2 2 2|
Olfactory Epithelium, Degeneration | 1 2 2 3 2 1 2 1 1 1 1 3 2 2 1|
Olfactory Epithelium, Metaplasia | 1 1 2 2 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 1 3 1 |
Respiratory Epithelium, Hyperplasia | 3 2 3 3 3 2 2 2 3 3 3 3 2 3 2 3 3 2 1 3 3 2 3 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 4 4 4 4 4 2 2 4 2 3 3 3 4 1 3 4 4 3 3 3 3 3 4|
Submucosa, Hyperplasia | |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|
DAY ON TEST | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|
| 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.75 MG/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Chronic | |
Synechia | 2 |
Anterior Chamber, Inflammation, | |
Suppurative | 1 |
Cornea, Degeneration | 2 |
Cornea, Inflammation, Suppurative | 3 |
Cornea, Mineralization | |
Lens, Degeneration | |
Retina, Degeneration | 2 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 |
Nephropathy | 2 3 3 4 2 2 2 3 3 3 3 3 3 2 3 1 4 3 2 3 2 2 1 4 3|
Pelvis, Epithelium, Hyperplasia | 2 |
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation | 2 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + A + + + + + + + + + + + +| 44 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M A + + + + + + + + + + + + + + + + + + + + +| 46 |
Parasite Metazoan | X X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + M + + + + + + + + + + + + + + + + + +| 45 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + M + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + I + + + + + + + + + + A + + I + + + + +| 43 |
Hyperplasia, Lymphoid | | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + + A A + + M + + + + + + + + +| 39 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 | 3 1.3|
Basophilic Focus | 1 1 X 1 1 1 1 3 1 2 1 1 1 1| 23 1.2|
Clear Cell Focus | 2 1 | 4 1.3|
Congestion | 3 | 1 3.0|
Degeneration, Cystic | 1 1 | 3 1.0|
Degeneration, Fatty | 1 1 1 1 | 10 1.5|
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | 1 2 1 | 5 1.4|
Hepatodiaphragmatic Nodule | X X X X X X | 9 |
Inflammation, Focal, Granulomatous | 1 1 1 1 | 8 1.0|
Leukocytosis | | 1 2.0|
Necrosis | 2 1 1 1 3 | 7 1.6|
Bile Duct, Hyperplasia | 2 2 1 2 1 1 1 1 1 1 2 1 1 1 2 1| 31 1.2|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Fat, Inflammation, Chronic | 2 2 | 2 2.0|
Fat, Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy | 2 1 3 1 1 2 2 1 1| 15 1.5|
Acinus, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + + + | 4 |
Palate, Cyst | 2 | 1 2.0|
Palate, Developmental Malformation | 2 | 2 2.0|
Palate, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 2 1 1 1 1 1 | 13 1.1|
Duct, Hyperplasia | 1 1 1 1 1 1 1 2 | 16 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 3 3.3|
Inflammation, Suppurative | 2 | 1 2.0|
Ulcer | 3 2 | 4 3.0|
Epithelium, Hyperplasia | 4 2 | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 1 | 2 1.5|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | | 1 2.0|
Ulcer | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 1 1 1 2 2 2 2 3 2 3| 48 1.9|
Atrium, Thrombosis | 3 1 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 1 1 2 1 2 2 1 2 2 2 2 2 2| 24 1.6|
Focal Cellular Change | 1 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 3 1 1 1 1 2 2 | 16 1.6|
Hyperplasia | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + M M + + + M + + + + + M +| 38 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 2 3 2 2 1 1 2 1 2 1 2 2 | 17 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 3 3.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M M + + + + + + M + + + + + + + + + M| 41 |
Hyperplasia | 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 3 3 2 | 12 2.3|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 2 2 1 1 1 2 2 | 9 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + M + + + + + + + I + + + + + M M + + + + + I + +| 42 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Hyperplasia, Squamous | 3 | 1 3.0|
Inflammation, Suppurative | 1 1 1 1 2 1| 10 1.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 4 1 | 10 1.5|
Inflammation, Suppurative | 3 2 1 2 1 3 2 1 2 1 1 1 1 | 18 1.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 8 |
Dilatation | 2 | 1 2.0|
Inflammation, Suppurative | 1 1 | 6 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 4 4 2 4 1 | 14 3.3|
Interstitial Cell, Hyperplasia | 1 1| 6 1.0|
Perivascular, Inflammation | 1 2 2| 6 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
Hyperplasia | 2 2 2 2 2 | 8 1.9|
Inflammation, Focal, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + I + + + + + + + + + + + + + M| 46 |
Hyperplasia | 2 3 2 2 2 2 2 2 | 18 2.1|
Inflammation, Focal, Granulomatous | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 1 2 3 3 2 2 3 | 10 2.3|
Hematopoietic Cell Proliferation | 2 3 2 3 | 7 2.4|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Metaplasia, Osseous | 2 | 1 2.0|
Necrosis | | 2 3.5|
Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + M M + M + + + + + + + M +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M M M M + M + + M + + M + M + I + M +| 24 |
Galactocele | 1 3 1| 8 2.0|
Hyperplasia | 2 1 2 | 8 1.8|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 | 2 1.5|
Periosteum, Proliferation | 1 1 2 2 1 1 1 1 2| 15 1.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 3 2.0|
Hydrocephalus | 2 | 1 2.0|
Meninges, Thrombosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 2 1 1 1 | 22 1.1|
Metaplasia, Squamous | 1 | 3 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 5 3.0|
Hemorrhage | 1 2 | 5 1.4|
Inflammation, Chronic, Focal | 2 1 1 1 1 1 | 9 1.3|
Alveolar Epithelium, Hyperplasia | 1 2 1 1 | 7 1.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 | 8 1.3|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 2 1 2 2 1 1 2 1| 24 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 1.0|
Inflammation | 3 2 3 3 2 3 1 3 3 3 1 2 1 3 2 2 1 2 2 3 3 3 3 2 3| 48 2.5|
Inflammation, Suppurative | 2 1 1 2 2 2 1 2 1 1 1 2 2 2 1 1 1 1 2 2 2 1 2 2| 47 1.6|
Thrombosis | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 1 1 1 2 | 14 1.6|
Olfactory Epithelium, Degeneration | 2 1 1 2 1 2 2 2 1 1 2 2| 27 1.6|
Olfactory Epithelium, Metaplasia | 2 1 2 2 2 1 2 2 3| 13 1.8|
Olfactory Epithelium, Metaplasia, | | |
Squamous | 2 3| 6 2.0|
Respiratory Epithelium, Hyperplasia | 3 2 2 2 3 3 1 2 2 3 2 3 2 4 2 2 1 3 3 2 3 2 3 3| 48 2.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 2 4 3 3 4 4 3 2 1 3 3 4 3 2 3 3 2 4 3 3| 44 3.1|
Submucosa, Hyperplasia | 2 1 2 | 3 1.7|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2 1 1 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Trachea | + I + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | 1 2 1 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 4 | 1 4.0|
Synechia | 1 | 2 1.5|
Anterior Chamber, Inflammation, | | |
Suppurative | 1 1| 3 1.0|
Cornea, Degeneration | 2 | 2 2.0|
Cornea, Inflammation, Suppurative | 2 2 1 | 4 2.0|
Cornea, Mineralization | 2 1 | 2 1.5|
Lens, Degeneration | 1 4 | 2 2.5|
Retina, Degeneration | 4 | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 2.0|
Nephropathy | 4 2 2 2 3 2 3 2 2 3 3 2 3 2 1 3 1 2 3 1 3 3 4 2 3| 50 2.5|
Pelvis, Epithelium, Hyperplasia | | 1 2.0|
Renal Tubule, Hyperplasia | 3 3 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05096-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC O-CHLOROBENZALMALONONITRILE (CS-2) Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:41:21
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5| |
| 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.75 MG/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M3 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 2.0|
Transitional Epithelium, Hyperplasia | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
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