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TDMS Study 05096-01 Pathology Tables

NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21




       Facility:  Battelle Northwest

       Chemical CAS #:  2698-41-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  A  +  +  +  +  +  +  A  I  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                      X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  I  A  +  +  +  +  +  I  A  +  A  A  +  +  I  +  I  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  I  A  +  +  +  +  +  A  A  I  +  A  +  +  I  +  I  I  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1           2           1           1     1  1     1     1  1  3        1|             
      Clear Cell Focus                     |                                           1                              |             
      Congestion                           |    2                                                                     |             
      Degeneration, Fatty                  |       2  3        2  2     2     3  1           1     2     1  3     1   |             
      Hematopoietic Cell Proliferation     |                         1                                      1         |             
      Hepatodiaphragmatic Nodule           |                         X        X                       X              X|             
      Inflammation, Focal, Granulomatous   |    1        1  2        1           2     1  1           2  2     1      |             
      Leukocytosis                         |                                     2                             2      |             
      Necrosis                             |          2                 2           2        1     1                  |             
      Bile Duct, Hyperplasia               |          1        1              1           1  2                       1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Inflammation, Chronic           |                      3                                                   |             
      Fat, Necrosis                        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                        1     1           1  1            |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
      Palate, Inflammation                 |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2                                                                  |             
      Inflammation, Suppurative            | 1           1  1                          1  1           1              1|             
      Duct, Hyperplasia                    | 1  1        2  1     1                 1  1  2                          1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Suppurative            |          2                                                           2   |             
      Ulcer                                |          2                                                           2   |             
      Epithelium, Hyperplasia              |       3  2                                                     4     3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                          2               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                            1                                         2   |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                            1           2        1                    3   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  2  2  2  1  1  1  1  2     1  2  2  1     1     1  2  1  2  1|             
      Atrium, Thrombosis                   |          4                 3                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1     1     1        1     2     1        1              1  1  4     3  1|             
      Focal Cellular Change                |                                              1     1        1            |             
      Hematopoietic Cell Proliferation     |       2                                2                                 |             
      Hyperplasia                          |                         3  3                       2                     |             
      Necrosis                             |          2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  I  M  +  M  +  M  +  M  +  M  +  I  +  I  +  +  I  +  +|             
      Hyperplasia                          | 1           2           2                       3                    2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  I  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                3     2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Angiectasis           |    4                                            2                        |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |          4                 1     3                 2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          3  1  2                                                  3     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Suppurative            |                         1                                   1        2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                3         |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Myelofibrosis                        |                            2                                            2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Inflammation, Focal,    |                                                                          |             
           Granulomatous                   |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |          3                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                          1               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +|             
      Hyperplasia                          |             2     2     2  2                             2               |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |          2        1                             1                        |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Inflammation, Granulomatous          |                                                             3            |             
      Necrosis                             |       2                                                                  |             
      Pigmentation, Hemosiderin            |                                                          2               |             
      Capsule, Thrombosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                1                    1                                    |             
      Hyperplasia                          |                         3                                            4   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                1     1   |             
      Osteopetrosis                        |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       2                                1        2                        |             
      Hydrocephalus                        |                   2                                      2               |             
      Meninges, Inflammation, Suppurative  |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2  1  1           1     1  2     1                    1        1|             
      Metaplasia, Squamous                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    4                                                                     |             
      Hemorrhage                           |                                  2     1        1                        |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |                         1     1           1  1     2     1     1        1|             
      Alveolar Epithelium, Hyperplasia     |                2                                         1               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                  2        1              1     1         |             
      Mediastinum, Inflammation, Chronic   |          2                                                               |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                | 1           1           1     2        1           2           1     1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2  1  1  1  2        2     1     1     2  1  1        1  1     1  1  1|             
      Inflammation, Suppurative            | 1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1     1|             
      Thrombosis                           |                            3     3     2                                3|             
      Nares, Inflammation, Chronic         |                                                             3            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            2                          1  1  2           1|             
      Olfactory Epithelium, Metaplasia     |                                                    1                     |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |    1  1                             1  1                 1        1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  1  1                       2            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                      +   |             
      Inflammation, Suppurative            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Lens, Degeneration                   | 2                                            1                    2      |             
      Retina, Degeneration                 | 3                                            3                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                             +                 +                     |             
      Inflammation, Suppurative            |    1                             1                 1                     |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                    +                     |             
      Inflammation, Suppurative            |                                                    1                     |             
      Acinus, Atrophy                      |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 6| 5| 5| 7| 7| 6| 5| 4| 5| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 4| 1| 0| 4| 4| 4| 0| 4| 4| 1| 6| 6| 0| 6| 4| 4| 5| 4| 8| 8| 6| 9| 6| 2| 4|             
                                           | 9| 6| 6| 5| 9| 9| 2| 1| 9| 8| 1| 7| 7| 7| 9| 9| 2| 3| 7| 9| 6| 4| 8| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 3  2  1  2  2  2  3     2  2  3  1  2  1  2  2  1     1  3  2  4  2  4  2|             
      Renal Tubule, Hyperplasia            |             1                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  I  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  40        |
      Parasite Metazoan                    |          X                             X                                 |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                             X            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  I  I  A  +  +  +  +  I  I  +  I  +  +  I  +  +  A  +  +|  31        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +  +  +  +  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 2              1  1           4              3                           |      5  2.2|
      Basophilic Focus                     | 2     1  2  2  2  1        1  1     1           1     2     1  1        1|     25  1.3|
      Clear Cell Focus                     |       2                                                                  |      2  1.5|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                      2  2        3     2              1                 2|     18  1.9|
      Hematopoietic Cell Proliferation     |                1  3  2                    1  1                           |      7  1.4|
      Hepatodiaphragmatic Nodule           |          X                                                  X            |      6     |
      Inflammation, Focal, Granulomatous   | 2     1  3  1  1  1                 1        1        2  1  1  1     1   |     23  1.3|
      Leukocytosis                         |                                                                          |      2  2.0|
      Necrosis                             |                      2  2              2        2  2                     |     10  1.8|
      Bile Duct, Hyperplasia               |                                                 1                 1      |      8  1.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                    +  +                                                |   4        |
      Fat, Hemorrhage                      | 3                                                                        |      1  3.0|
      Fat, Inflammation, Chronic           |                      2  2                                                |      3  2.3|
      Fat, Necrosis                        |                      4  4                                                |      3  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |       1                             1  2  3           2           1  1   |     11  1.4|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Inflammation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                         2|      2  2.0|
      Inflammation, Suppurative            | 1     1        1  1                                   1     1  2     1  2|     16  1.1|
      Duct, Hyperplasia                    | 1     1  1     1  1           1     1           1     2     1  2  1  1   |     22  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                 2                       3|      3  2.3|
      Inflammation, Suppurative            |                               2  3                                       |      4  2.3|
      Ulcer                                |                               3  3                                      2|      5  2.4|
      Epithelium, Hyperplasia              |          1        2              1              3           1           3|     10  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                 2                        |      2  2.0|
      Inflammation, Chronic                |                      3  3        3           2                          2|      5  2.6|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Pigmentation, Hemosiderin            |                                                          2               |      1  2.0|
      Ulcer                                |                      3  4        4                 3                    4|      9  2.8|
      Epithelium, Hyperplasia              |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 2     2  2  2  2  3     1     2  2  2  2     2  2  1  2  1  1  1  2  1   |     42  1.5|
      Atrium, Thrombosis                   |                                  4                                       |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  | 1     2  2  1     2  3  3     1              1  2     1        1     2  2|     26  1.6|
      Focal Cellular Change                |       1        1                                                        2|      6  1.2|
      Hematopoietic Cell Proliferation     |                   1  1  1                 1  1  2           1     1      |     10  1.3|
      Hyperplasia                          | 2                 3        2                    2                        |      7  2.4|
      Necrosis                             |                         1        1                                       |      3  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  37        |
      Hyperplasia                          |                   2              2           2                 1  1      |     10  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|  40        |
      Hyperplasia                          |                               2                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                                                   2      |      3  2.7|
      Pars Distalis, Cyst                  |          1                       3                                       |      3  2.0|
      Pars Distalis, Hyperplasia           |       3              1  2  3     2                          2            |     10  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  48        |
      C-Cell, Hyperplasia                  | 1              1  2        2        1                                    |     10  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 1     3              3                          3  2           1     1  1|     11  1.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |             1           2                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           | 2                                         4                              |      2  3.0|
      Hyperplasia, Cystic                  |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Focal, Granulomatous   |                                                             2            |      1  2.0|
      Myelofibrosis                        | 2                                                                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Inflammation, Focal,    |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                           2                              |      1  2.0|
      Hyperplasia                          |          1        1                                         1            |      4  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |       2     2     1                    2     1        2  2  2  1     1   |     15  1.7|
      Inflammation, Focal, Granulomatous   |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |                                                                X         |      1     |
      Fibrosis                             |                               1  2                                       |      5  1.4|
      Hematopoietic Cell Proliferation     |                   3  3  3           2     2                              |      6  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Necrosis                             |                                                       2                  |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Capsule, Thrombosis                  |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  A  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Galactocele                          |                                                                          |      2  1.0|
      Hyperplasia                          |                                  3           2     2  2                  |      6  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                         1|      3  1.0|
      Osteopetrosis                        |       2           2                          2                           |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                      2                             2     2               |      6  1.8|
      Hydrocephalus                        |                                     2                                    |      3  2.0|
      Meninges, Inflammation, Suppurative  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |          1     1     1  1  2     1        2  1  1     1  2           1  2|     22  1.3|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                     3                                    |      2  3.5|
      Hemorrhage                           |                                                                          |      3  1.3|
      Infiltration Cellular, Mixed Cell    |                   3  2                    2                              |      3  2.3|
      Inflammation, Chronic, Focal         |       1        1     2                 1     1        1     1  2         |     16  1.2|
      Alveolar Epithelium, Hyperplasia     |                               4                                         3|      4  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                        1     1                           |      6  1.2|
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |       1  1     1           1        1        1        1  1     2         |     18  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 1     1  2  1  2  1  2  2  1  1     1     1  1     1  1  2  2     1  2  1|     37  1.3|
      Inflammation, Suppurative            | 1     1  2  1  1  1  2  2  1  1  2  1  1  1     1  2  1  1  1  1  1  1  1|     46  1.1|
      Thrombosis                           |                      2  3        3     3                                 |      8  2.8|
      Nares, Inflammation, Chronic         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             1        1  1                 1  2     1        2  1        2|     14  1.4|
      Olfactory Epithelium, Metaplasia     |                         2                                         1      |      3  1.3|
      Respiratory Epithelium, Hyperplasia  |                      1  1              1                                 |      3  1.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |          2              2        1        1        2     1               |     12  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 5| 7| 7| 6| 4| 6|            |
                             DAY ON TEST   | 4| 8| 4| 4| 4| 4| 1| 6| 4| 4| 4| 4| 4| 1| 7| 4| 6| 7| 4| 8| 4| 4| 0| 6| 8|            |
                                           | 9| 3| 9| 9| 9| 9| 4| 3| 1| 9| 9| 9| 9| 4| 6| 9| 7| 9| 9| 8| 9| 9| 1| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                      2                                                   |      1  2.0|
      Lens, Degeneration                   |                                  1                                2      |      5  1.6|
      Retina, Degeneration                 |                                  3                                      1|      4  2.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                +         |   4        |
      Inflammation, Suppurative            |                                                                3         |      4  1.5|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |       +                          +                                       |   3        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Acinus, Atrophy                      |       2                          1                                       |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                         2                                                |      1  2.0|
      Mineralization                       |                         2                                                |      1  2.0|
      Nephropathy                          | 2     3  1  2  2  3  1  3  2  3  1  2  1     3  1  1  3  1  1  2  2     4|     45  2.1|
      Renal Tubule, Hyperplasia            |                   1                                            1         |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                      1                                                   |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +     +           +  +  +  +  +  M           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +     +           +  +  +  +  A  A           +  +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +     +           +  I  +  +  A  A           +  +  A  +     A|             
      Inflammation, Suppurative            |                                                                          |             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  I     +     +           +  A  +  +  A  A           +  +  A  +     +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     M     +           +  +  +  +  A  A           +  +  A  +     +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +           +  +  +  +  A  A           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +           +  +  +  +  A  A           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  I     +     +           +  A  +  +  A  A           +  I  A  A     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  I     +     I           +  +  +  A  A  A           +  A  A  I     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                             3                       2                  |             
      Basophilic Focus                     |    X  2  2     1           2              1     1  1  1              X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |       3     3     2     1  1                 3           3  2     3  1   |             
      Hematopoietic Cell Proliferation     |    1                             3                                       |             
      Hemorrhage                           |                2                                                         |             
      Hepatodiaphragmatic Nodule           |       X  X                                                               |             
      Hyperplasia                          |                            3                                         3   |             
      Inflammation, Focal, Granulomatous   | 2        3     1     2  1  2        1           2     2        1  2  1   |             
      Leukocytosis                         |                      1                                                   |             
      Necrosis                             |          2  3                    1                       2  1        2  1|             
      Thrombosis                           |                               2                                          |             
      Bile Duct, Hyperplasia               |             1     1           2     1           1        2  1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                             +            |             
      Fat, Inflammation, Chronic           |                               3                                          |             
      Fat, Necrosis                        |                               2                             3            |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Acinus, Atrophy                      |             1                                                            |             
      Acinus, Fibrosis                     |       3                                                                  |             
      Acinus, Focal Cellular Change        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Inflammation, Suppurative            |    1                                                                     |             
      Duct, Hyperplasia                    |    1              1                 1                       1     1     1|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +     +        +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +     +        +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Inflammation, Chronic                |       2                    3                                      3  3   |             
      Inflammation, Suppurative            |                                  3                                       |             
      Ulcer                                |       1                    3     3                                1  2   |             
      Epithelium, Hyperplasia              |       3                    2     1                                3  3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +           +  +  +  +  +  A  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  | +                                                                        |             
      Epithelium, Hyperplasia              | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +           +  +  +  +  +  +           +  +  +  +     +|             
      Cardiomyopathy                       |    1  1  1                    1  1  1  2  2                 1     1     2|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                        1                                 |             
      Atrium, Congestion                   |                               4        3                                 |             
      Atrium, Thrombosis                   |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +     +           +  +  +  M  +  A           +  +  +  +     +|             
      Degeneration, Fatty                  |       2     2     1                       2                 2     1     2|             
      Focal Cellular Change                |    1                                                                     |             
      Hematopoietic Cell Proliferation     |                                  4                                      2|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +     +           +  M  +  +  +  A           I  +  I  +     +|             
      Hyperplasia                          |                                     1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +     +           +  +  +  +  +  A           M  M  I  +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +|             
      Degeneration, Cystic                 |                            3                                             |             
      Pars Distalis, Angiectasis           | 2                                                                        |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2                          2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +     +           +  +  +  +  A  A           +  +  A  +     +|             
      C-Cell, Hyperplasia                  |    1        1                 1                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +     +  +        +  M  +  +  +  M           +  +  +  M     M|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |             1  1                                                         |             
      Proliferation                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +     +        +  +  +  +  +  +  +           +  +  +  +  +  +|             
      Submucosa, Hyperplasia               |                                                          3               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Inflammation, Focal,     |                                                                          |             
           Granulomatous                   |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +     +           +  +  +  M  +  A           +  +  +  +  +  +|             
      Hyperplasia                          |    2                                2                                   2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             2                 2                                          |             
      Hematopoietic Cell Proliferation     |    2                             4                                      2|             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation, Hemosiderin            |                                           2                    2         |             
      Capsule, Inflammation, Suppurative   |                                                                      1   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     M     +           +  +  +  +  +  M           +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |       1                                                                  |             
      Hyperplasia                          |    1        2  1                                      1                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +        +  +  +  +  +  M  +           +  +  +  +     +|             
      Acanthosis                           |                                                                          |             
      Ulcer                                |                                  3  4                                    |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +     +           +  +  +  +  +  +           +  +  +  +     +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +     +           +  +  +  +  +  +           +  +  +  +     +|             
      Hemorrhage                           |                   2                          2                           |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +     +     +           +  +  +  +  +  A           +  +  A  +     +|             
      Inflammation, Suppurative            |             1     1           1     1     2                              |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                              3         |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                  3                                       |             
      Inflammation, Chronic, Focal         |       2                    1                                             |             
      Inflammation, Suppurative            |                                           3                              |             
      Alveolar Epithelium, Hyperplasia     |       2        3                                            3            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               1                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                            1                             1        1  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1           1  1  1  1           2     2        1  1        2  1      |             
      Inflammation, Suppurative            | 1  1        1     1  2  1  1  2  1  1           1  1  1  3  1  1     1   |             
      Thrombosis                           |                                                          3  2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                   2                 1  1                          2     2|             
      Olfactory Epithelium, Metaplasia     |                      2                                                   |             
      Respiratory Epithelium, Hyperplasia  |                                     1                    1  1            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |       1                                                     1            |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |             1                    1  2                                   1|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
      Inflammation, Suppurative            |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +     +  +                                                         |             
      Synechia                             |       2                                                                  |             
      Lens, Degeneration                   |                3                                                         |             
      Retina, Degeneration                 |                4                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                       +        +         |             
      Inflammation, Suppurative            |                                                       1                  |             
      Acinus, Atrophy                      |                                                       2        2         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 6| 4| 7| 7| 7| 5| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 9| 5| 3| 5| 4| 5| 5| 5| 1| 6| 6| 2| 0| 3| 5| 5| 5| 2| 7| 1| 0| 5| 5|             
                                           | 2| 2| 4| 2| 0| 2| 5| 2| 2| 2| 5| 6| 8| 0| 1| 8| 2| 2| 2| 7| 1| 9| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +           +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Nephropathy                          |    1  2     2     1           3     1  2  1  1  3        2  1  2  2  4  2|             
      Artery, Hyperplasia                  |                                        2                                 |             
      Capsule, Inflammation                |                                                                      1   |             
      Renal Tubule, Hyperplasia            |                                                                      3   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +     +           +  +  +  +  +  A           +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +        +  +  +  +  +  +  +  +  +           +           +      |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +        +  +  +  +  +  +  +  +  +           +           +      |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +        +  +  +  +  +  +  +  +  A           I           +      |  20        |
      Inflammation, Suppurative            |                               1                                          |      1  1.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +        +  +  +  M  +  +  +  +  A           +           +      |  20        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +        +  +  +  +  +  +  +  +  +           +           +      |  23        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +        +  +  +  +  +  +  +  +  +           +           +      |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +        +  +  +  +  I  +  +  +  +           +           +      |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          I        +  I  +  +  +  +  +  +  +           +           +      |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          I        I  +  I  +  +  +  +  +  A           A           A      |  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    1                                            2              2         |      6  2.0|
      Basophilic Focus                     |       1     1  1                                1        1     2     1  1|     18  1.3|
      Clear Cell Focus                     |                                                 1  1                     |      2  1.0|
      Degeneration, Fatty                  | 2  2     3        2  2     2     2                             2        3|     19  2.2|
      Hematopoietic Cell Proliferation     |                                        1           1                 1   |      5  1.4|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Hyperplasia                          |                                                                2         |      3  2.7|
      Inflammation, Focal, Granulomatous   |       1     1  1        1              1     1  2     1        1  1  2   |     23  1.4|
      Leukocytosis                         |                                                                          |      1  1.0|
      Necrosis                             |    2                 1                 1  2        1                    1|     13  1.5|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    2     1                       2                                       |     10  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                +            |   4        |
      Fat, Inflammation, Chronic           |                            3                                3            |      3  3.0|
      Fat, Necrosis                        |                                                             3            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +        +  +  +  +  +  +  +  +  A           +           +      |  25        |
      Acinus, Atrophy                      |                                        1                          1      |      3  1.0|
      Acinus, Fibrosis                     |                                                                          |      1  3.0|
      Acinus, Focal Cellular Change        |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +        +  +  +  +  M  +  +  +  +           +           +      |  25        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Duct, Hyperplasia                    |                                     2                 1                  |      8  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     +  +  +  +  +  +  +  +  +  +           +        +  +     +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     +  +  +  +  +  +  +  +  +  +           +        +  +     +|  33        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |          2        2        3                                   3  2      |      9  2.6|
      Inflammation, Suppurative            |                      2                                                   |      2  2.5|
      Ulcer                                |          1           2     4                                   3  3      |     10  2.3|
      Epithelium, Hyperplasia              |          3           2     2                                   3  3      |     10  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     +  +  +  +  +  +  +  +  +  +           +        +  +     +|  31        |
      Inflammation, Chronic                |                1           2  1                                2         |      4  1.5|
      Inflammation, Suppurative            |                                                                         1|      1  1.0|
      Pigmentation, Hemosiderin            |                2                                                         |      1  2.0|
      Ulcer                                |                            3  2           3                    2         |      4  2.5|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +        +  +  +  +  +  +  +  +  +           +           +      |  28        |
      Cardiomyopathy                       |          1        1  1  1  1  2  2     1              1           1      |     21  1.2|
      Inflammation, Suppurative            |                               2                                          |      1  2.0|
      Mineralization                       |                               1                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
      Atrium, Congestion                   |                                                                          |      2  3.5|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +     +  +  +  +  +  +  +  +  A           +           +      |  26        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +     +  +  +  +  +  +  +  +  A           +           +      |  25        |
      Degeneration, Fatty                  |          2           3     2           2                          2      |     12  1.9|
      Focal Cellular Change                |                                                                   1      |      2  1.0|
      Hematopoietic Cell Proliferation     |                                     1  2                                 |      4  2.3|
      Necrosis                             |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +     +  +  +  I  M  +  +  +  A           +           +      |  21        |
      Hyperplasia                          |                                        2                                 |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +        M  +  +  +  +  +  +  +  A           +           +      |  24        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     +  +  M  +  +  +  M  +  +  +           +           +      |  22        |
      Hyperplasia                          |                1              2                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +|  44        |
      Degeneration, Cystic                 |                                  3     2                                 |      3  2.7|
      Pars Distalis, Angiectasis           |    3                                                                     |      2  2.5|
      Pars Distalis, Hemorrhage            |          1                          2                                    |      2  1.5|
      Pars Distalis, Hyperplasia           |          3           2              2     2                              |      6  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +     +  +  +  +  +  +  +  +  +  A           +           +  +  +|  26        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                                   3      |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +        +  +  +  +  +  +  +  +  +           +           +      |  25        |
      Inflammation, Suppurative            |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      2  2.0|
      Cyst                                 |                      3                                                   |      3  1.7|
      Proliferation                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +        +  +  +  +  +  +  +  +  +           +        +  +      |  31        |
      Submucosa, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                            +                                             |   1        |
      Inflammation, Suppurative            |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +        +  +  +  +  +  +  +  +  +           +           +      |  26        |
      Myelofibrosis                        |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mesenteric, Inflammation, Focal,     |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Focal, Granulomatous   |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +        +  +  +  +  M  +  +  +  +           +           I      |  25        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                        2                                 |      4  2.5|
      Inflammation, Granulomatous          |                                                                      2   |      1  2.0|
      Pigmentation, Hemosiderin            |                         2                                                |      3  2.0|
      Capsule, Inflammation, Suppurative   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +        +  +  M  +  +  +  +  M  +           +           +      |  23        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                         1                                      1         |      3  1.0|
      Hyperplasia                          |          1     1                                         2        2  1   |      9  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +     +  +  +  +  +  +  +  +  +     +     +     +     +     +|  33        |
      Acanthosis                           |                               2                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  3.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                               3                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +        +  +  +  +  +  +  +  +  +           +           +     +|  29        |
      Fibrous Osteodystrophy               |                               1                                          |      1  1.0|
      Osteopetrosis                        |       3                                                                 2|      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +        +  +  +  +  +  +  +  +  +           +        +  +      |  28        |
      Hemorrhage                           |                      1                    2                              |      4  1.8|
      Hydrocephalus                        |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +        +  +  +  +  +  +  +  +  A           +           +      |  24        |
      Inflammation, Suppurative            |                   1              1  1                 1           2      |     10  1.2|
      Metaplasia, Squamous                 |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                            3           3                                 |      4  2.8|
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |       1  1                             1        1  1                     |      7  1.1|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                        4                                 |      4  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1     2                       2                                       |      4  1.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |       1     1     1                                1  1              1   |     10  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |    1  1                 1     1     1              1     2  1        1   |     21  1.2|
      Inflammation, Suppurative            | 1  1           1  1  2  1     2              1  1  1     1        1     1|     30  1.2|
      Thrombosis                           |          2           2                                                  1|      5  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |          1     2     3                 1                    2  1  2  2   |     13  1.7|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 6| 5| 6| 4| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 5| 5| 5| 0| 5| 5| 1| 8| 0| 9| 6| 0| 7| 1| 2| 5| 5| 5| 8| 5| 5| 5| 3| 5| 5|            |
                                           | 2| 2| 2| 2| 2| 2| 7| 7| 8| 0| 6| 2| 1| 4| 9| 2| 2| 2| 4| 2| 2| 2| 7| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  1.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +        +  +  +  +  +  +  +  +  I           +           +      |  25        |
      Inflammation, Suppurative            |                         1                                                |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +     +                                                   |   5        |
      Synechia                             |                      3                                                   |      2  2.5|
      Lens, Degeneration                   |                4     3                                                   |      3  3.3|
      Retina, Degeneration                 |                4     4                                                   |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
      Metaplasia, Squamous                 |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                        +                                 |   3        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                        2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +  +  +  +  +  +  +     +  +  +        +  +     +|  37        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Nephropathy                          | 3  1     1     3  2  2  2  3     1  1  2  1     2  3  2        4  3     2|     34  2.0|
      Artery, Hyperplasia                  |                                                                          |      1  2.0|
      Capsule, Inflammation                |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +        +  +  M  +  M  +  +  +  +           +           +      |  24        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|             
                                           | 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +           +  +  +        +     +        +                    +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +           +  +  +        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        A           +  +  A        +     A        A                    A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        A           +  +  +        +     A        A                    A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +           +  +  +        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        A           +  +  +        +     A        A                    +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        A           +  +  +        +     A        A                    +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        A           M  +  I        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | I        A           +  +  I        +     A        A                    A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       1                  |             
      Basophilic Focus                     |    2  3  1  2  1                       1     2  X     1     1  1  1  1   |             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |          1                    1           2                              |             
      Hematopoietic Cell Proliferation     |                            2  1                                   1      |             
      Hepatodiaphragmatic Nodule           |       X                 X           X  X                    X  X        X|             
      Inflammation, Focal, Granulomatous   | 2  1  1  2     1              1  1     2  1     2  1  1     1  1         |             
      Necrosis                             |                   1     1        2     2                                 |             
      Pigmentation, Bile                   |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                   1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Inflammation, Chronic           |                                  3                                       |             
      Fat, Necrosis                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +           +  +  +        +     +        +                    A|             
      Acinus, Atrophy                      |                         1  1                       1                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 | +                                                                        |             
      Palate, Developmental Malformation   | X                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +           M  +  +        +     M        +                    +|             
      Inflammation, Suppurative            |                            1                                             |             
      Duct, Hyperplasia                    | 1                          1                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +        +           +  +  +        +     +        +                    +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +        +           +  +  +        +     +        +                    +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                           3                              |             
      Ulcer                                |                                           4                              |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +        +           +  +  +        +     A        +                    +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                            2                                             |             
      Pigmentation, Hemosiderin            |                                                                         2|             
      Ulcer                                |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|             
                                           | 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +           +  +  +        +     +        +                    +|             
      Cardiomyopathy                       | 1        2           1  1  1              1        1                    1|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +        +  +  +  +        +     +        +        +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +        +  +  +  +        +     +        +        +           +|             
      Degeneration, Fatty                  |                   2     2  3                                             |             
      Hematopoietic Cell Proliferation     |                      2     1                                             |             
      Hyperplasia                          |                            2                                             |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +        +        +  +  +  +        I     +        +        +           M|             
      Hyperplasia                          |          1        4  2  2  2                                             |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +           +  +  +        +     +        +                    A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +           +  +  +        M     +        +                    +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +           +  +  +        +     +        +                    A|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +           +  +  +        +     +        +              +     +|             
      Hyperplasia                          |                            3                                             |             
      Inflammation, Suppurative            |                            2                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +           +  +  +        +     +        +                    +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +           +  +  +        +     A        +                    +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|             
                                           | 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                      1   |             
      Inflammation, Focal, Granulomatous   |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +        +           M  +  +        +     M        +                    +|             
      Hyperplasia                          |                                     1                                    |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                           1           1                  |             
      Hematopoietic Cell Proliferation     |                      1     3                                             |             
      Hemorrhage                           |                            3                                            3|             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                            3                                            3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +           +  +  +        +     +        +                    +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                1           1  1  1              1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +        +  +  +  +     +  +  +  +        +     +              +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Suppurative            |                      1                                                   |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +           +  +  +        +     +        +                    +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +           +  +  +        +     +        +                    +|             
      Hemorrhage                           |                         2  3                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +        +           +  +  +        +     A        +                    A|             
      Inflammation                         |          1                                                               |             
      Inflammation, Suppurative            |                         1                                                |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                      3                     |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                         1  1                                             |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |    1  1        1  1     2     1  1     1     1  1     1  1  1     1  1   |             
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               1                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 4| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 5| 5| 9| 5| 5| 5| 3| 8| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|             
                                           | 7| 1| 1| 0| 1| 1| 1| 6| 0| 4| 1| 1| 7| 1| 6| 1| 1| 8| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Mononuclear Cell                | 2  1        1  1              1  1  1        1  1  1  1  1           1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2  2  1  1  2  2     2     2  1     1     1  1  1  2     1  2  1  1   |             
      Inflammation, Suppurative            | 1  1  1  1  1  1  2        2  1  1  1  1  1  1  1  1  1     1  1  1  1   |             
      Thrombosis                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    1     1        1                       1           1                  |             
      Olfactory Epithelium, Degeneration   |          1                                                               |             
      Olfactory Epithelium, Metaplasia     |                                              2                           |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                         2|             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |          2                 2                       1                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +           +  +  +        +     A        +                    A|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                         +            |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Lens, Degeneration                   |                                                             4            |             
      Retina, Degeneration                 |                                                             4            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                            +     +     +                                 |             
      Acinus, Atrophy                      |                            2     2     2                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +        +  +  +  +  +  +     +        +  +     +        +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2        2  2        1  1  2  3  3  2     1        2  2     2        3  1|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +           +  +  +        +     +        +                    +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +     +  M  +  +  +  +              +                 +  +   |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +     +  A  A  +  +  +              +                 +  +   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  A  +     +  M  A  +  A  +              I                 I  +   |  10        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +     +  A  A  +  +  +              +                 +  +   |  15        |
      Parasite Metazoan                    |                   X        X                                             |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       M  A  +     +  A  A  +  +  +              +                 +  +   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +  I     +  A  A  +  +  +              +                 +  +   |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  I     +  A  A  +  +  +              +                 +  +   |  15        |
      Ulcer                                |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       I  A  I     +  A  A  A  A  A              I                 I  I   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       I  +  I     +  A  A  I  I  +              A                 A  +   |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                             2     1                    1        1   |      6  1.3|
      Basophilic Focus                     |    1           2                    1  1  1  1     1     1  1  1        1|     24  1.3|
      Congestion                           |          3                                                               |      1  3.0|
      Degeneration, Fatty                  |             3     2                             3                 2  2   |      8  2.0|
      Hematopoietic Cell Proliferation     |                         2     1        1              3  1  1            |      9  1.4|
      Hepatodiaphragmatic Nodule           |             X                                                            |      8     |
      Inflammation, Focal, Granulomatous   | 1  1     1                 1     2  1     1  1     2     1     1        1|     26  1.2|
      Necrosis                             | 1     2  1                                                        3  1   |      9  1.6|
      Pigmentation, Bile                   |                               1                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                1  1                                   2              1   |      6  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   2        |
      Fat, Inflammation, Chronic           |                2                                                         |      2  2.5|
      Fat, Necrosis                        |                2                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +     +  A  +  +  +  +              +                 +  +   |  19        |
      Acinus, Atrophy                      |             2     2                                                      |      5  1.4|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Palate, Developmental Malformation   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +     +  +  +  +  +  +              +                 +  +   |  19        |
      Inflammation, Suppurative            |       1     1                                                            |      3  1.0|
      Duct, Hyperplasia                    |       1                 1     1  1                                1      |      7  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +     +  +  +  +  +  +        +     +                 +  +   |  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
      Inflammation, Chronic                |          3                                                               |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Ulcer                                |                               1                                          |      2  2.5|
      Epithelium, Hyperplasia              |          4                                                               |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +     +  A  +  +  +  +        +     +                 +  +   |  20        |
      Hemorrhage                           |                                           3                              |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Ulcer                                |                               3                                   1      |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
      Cardiomyopathy                       |       1  2  1     2  1        1                                   2  1   |     16  1.3|
      Atrium, Thrombosis                   |                                                                   3      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +     +  A  +  +  +  +              +           +     +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +     +  A  +  +  +  +              +           +     +  +   |  23        |
      Degeneration, Fatty                  |                               2                 1           1     1      |      7  1.7|
      Hematopoietic Cell Proliferation     |                         2                                                |      3  1.7|
      Hyperplasia                          |                                  2                                2      |      3  2.0|
      Necrosis                             |       2                                                                  |      1  2.0|
      Thrombosis                           |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +     +  A  +  M  +  M              +                 +  +   |  18        |
      Hyperplasia                          |                   1                                               2      |      7  2.0|
      Thrombosis                           |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +     +  A  +  +  +  +           +  +                 +  +   |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +     +  +  +  +  +  M              M                 +  +   |  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +  +     +  +   |  42        |
      Degeneration, Cystic                 |                                                                      2   |      1  2.0|
      Pars Distalis, Hyperplasia           |       2           3     3     2                             2            |      6  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  A  +     +  A  +  +  +  +              +                 +  +   |  18        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  +  +     +  M  +  +  +  +              +                 +  +   |  21        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                               3                                   1      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                          3               |      1  3.0|
      Cyst                                 |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +     +  +  +  +  +  +              +  +              +  +   |  23        |
      Hemorrhage                           |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |          +                                                               |   1        |
      Inflammation, Suppurative            |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +     +  A  +  +  +  +              +                 +  +   |  19        |
      Myelofibrosis                        |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                    1                    1|      3  1.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +  +     +  +  +  M  +  +              +     +           +  +   |  19        |
      Hyperplasia                          |                                  1                                       |      2  1.0|
      Necrosis                             |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                       2                  |      3  1.3|
      Hematopoietic Cell Proliferation     |                         2     4                       4  1        2      |      7  2.4|
      Hemorrhage                           |             3                                                            |      3  3.0|
      Necrosis                             |             3                                                            |      1  3.0|
      Thrombosis                           |             3                                                            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +  +     +  M  +  +  +  +              +                 +  +   |  20        |
      Inflammation, Chronic                |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 1              1           1  1                                          |     10  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +  +  +     +     +  +     +        +  +  +   |  30        |
      Cyst Epithelial Inclusion            |                                                                      X   |      1     |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Necrosis                             |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
      Osteopetrosis                        |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +     +  +  +  +  +  +              +                 +  +   |  21        |
      Hemorrhage                           |                               2                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +  +  +     +  A  +  +  +  +              +                 +  +   |  18        |
      Inflammation                         |                         2                                                |      2  1.5|
      Inflammation, Suppurative            |       1     1                 1  1              1                        |      6  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    3     3                       3                                       |      5  3.0|
      Edema                                |                      3                                                   |      1  3.0|
      Hemorrhage                           |                   2                                                      |      3  1.3|
      Infiltration Cellular, Mixed Cell    |                         2                             3                  |      2  2.5|
      Inflammation, Chronic, Focal         |    1     2        2                       1  1        1  1     1        1|     24  1.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                1  2        1                                      1      |      5  1.2|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                | 1  1     2     1           1              1              1     1         |     21  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 1  1     1  1  2  2                 1  1  2  1     1     2  1  2        1|     34  1.4|
      Inflammation, Suppurative            | 1  1  2  2  2  1  1     1  1  1     1  1  1  1  2  1     1  1  1  1  1  1|     43  1.1|
      Thrombosis                           |       1                                         1                 3      |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 2        1        2        1                                      1  1   |     11  1.2|
      Olfactory Epithelium, Degeneration   |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |       2  1        2           1                                   2  1   |      6  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |          1        1           2                                      2   |      5  1.6|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |          2                                      1                 1      |      6  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +     +  A  +  +  +  +              +                 +  +   |  18        |
      Inflammation, Suppurative            |       1                          1                                       |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   3        |
      Cornea, Inflammation, Suppurative    |                               2                                          |      1  2.0|
      Lens, Degeneration                   |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |          +              +                                   +        +   |   7        |
      Acinus, Atrophy                      |          2              2                                   2        2   |      7  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 7| 3| 4| 5| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 5| 5| 7| 0| 0| 5| 3| 7| 6| 4| 3| 3| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 3| 6| 5|            |
                                           | 1| 1| 1| 9| 6| 1| 2| 0| 5| 9| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 3| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  A  +  +  +  +     +        +        +     +  +  +   |  30        |
      Cyst                                 |                                                                   X      |      1     |
      Inflammation, Suppurative            |                               3                                          |      1  3.0|
      Mineralization                       |                   2                                                      |      1  2.0|
      Nephropathy                          |    2  1  3  2     2        1  2  3     3        1        2     2  2  2   |     29  2.0|
      Renal Tubule, Hyperplasia            |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  M  +     +  +  +  +  +  +              +                 +  +   |  20        |
      Inflammation, Suppurative            |                               4                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                    X                             X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X              X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                    X                          X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +|             
      Ulcer                                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2                                                         |             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  I  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2     1                    1  2                           |             
      Basophilic Focus                     |                      1  1     1     1  1           1  1     1  1  1  1   |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |       2     2     1     2                                1               |             
      Eosinophilic Focus                   |          X                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                             X           X|             
      Inflammation, Focal, Granulomatous   | 1        1  1  1     2  1     2     1     1        1  1  2           1  1|             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |                   1     1        1        2                             1|             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |             1                    2                       1           1   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    3                    2              1  1           1                  |             
      Acinus, Inflammation                 |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1           1                       1                          1  1|             
      Duct, Hyperplasia                    |                   2  1        1     1  1  1        1  1  1           1  1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       3                                            2                     |             
      Inflammation, Suppurative            |             2                                                            |             
      Ulcer                                |       3     3                                      2                     |             
      Epithelium, Hyperplasia              |       3     2                                      2                    1|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |       2                                                                  |             
      Inflammation, Suppurative            |                                                                         1|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |       2                                                                 1|             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2  2  3  1  2  2  1  2  2  1  2  2  3  2  1  1  1  2  2  1  2  1  2|             
      Atrium, Inflammation                 |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 3     2  2  3        1  1  2  1  2  2     1     1  1  1           4  2  1|             
      Ectopic Tissue                       |                                                                          |             
      Focal Cellular Change                |          1                                         2  1  1               |             
      Hematopoietic Cell Proliferation     |             1                       2  2           1        1  1         |             
      Hyperplasia                          | 3                                   2              2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  I|             
      Hyperplasia                          |                3              3  2  2                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                 2                        |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       4                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                           2              1     4         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2        1                                                   |             
      Hyperplasia                          |    3                                                                     |             
      Inflammation, Suppurative            |    2        1              1           1                                 |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2        2                                       |             
      Cyst                                 |                                        4                                1|             
      Hyperplasia                          |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hemorrhage                           |                   4                                                      |             
      Hyperplasia, Cystic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                       3                  |             
      Hyperplasia, Neutrophil              |       3                                                                  |             
      Myelofibrosis                        |                1  1                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +|             
      Hyperplasia                          |          2     2        2  2                    2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      2   |             
      Hyperplasia                          |       3     1  2  1  2  2  1        1  1                 1              2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             1                          2                                 |             
      Hematopoietic Cell Proliferation     |    2  2                                                                  |             
      Hemorrhage                           |                                                                3         |             
      Inflammation, Granulomatous          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                          3              1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |          1  4     2                                               1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia               |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                2                                   2           4         |             
      Periosteum, Proliferation            |             1  1  1              2     2  1     2                       1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       3                                                                  |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            | 2        2     1     1  1  1     2        1              1     2        1|             
      Metaplasia, Squamous                 |                                                                2         |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2                                                         |             
      Hemorrhage                           | 2                                            1                    2     1|             
      Inflammation, Chronic, Focal         | 1        1  1  1  1  1  2  1  2  2     1  1  1  1        1  1  1        1|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                             1                             3            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  1     2     1        1        2        1     1     1  1               |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                | 1  2  1  2     1  1  1  2  2  2              1              2           1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  3  2  2  3  2  4  2  3  3  4  2  2  2  3  3  3  2  1  2  3  2  3  2  1|             
      Inflammation, Suppurative            | 1  2  1  1  1  1  2  2  1  1  1  2  1  1  2  1  2  2  1  1  2  1  1  1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       3              2  1           2                    1     1         |             
      Olfactory Epithelium, Degeneration   |          1  2        1           2  2  1  1  1  2        2     3  2     2|             
      Olfactory Epithelium, Metaplasia     |          1  1                    2  1        2                 3  1     2|             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                2  1      |             
      Respiratory Epithelium, Hyperplasia  | 2  2  2  2  3  2  3     2  2  3  2  2  2  2  2  3  2  2  2  3  2  3  2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 3  3  3  3  4  2  4  3  3  3  3  4  3  4  4  3  3  4  4  3  3  3  3  3  4|             
      Submucosa, Hyperplasia               |    2                                1                                    |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     | 1              1  1              1  1              2  1  2     1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1                       1                        |             
      Epithelium, Hyperplasia              |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Synechia                             |                                                       3                  |             
      Cornea, Hyperplasia                  |             2                                                            |             
      Cornea, Inflammation, Suppurative    |             4                                                            |             
      Lens, Degeneration                   |                            4                                             |             
      Lens, Mineralization                 |                            2                                             |             
      Retina, Degeneration                 |                            4                                2           3|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +                          +                       +                 +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| 5| 4| 6|             
                             DAY ON TEST   | 0| 5| 9| 5| 0| 5| 5| 6| 5| 5| 5| 5| 8| 5| 5| 5| 5| 3| 6| 3| 5| 5| 7| 7| 3|             
                                           | 6| 0| 4| 0| 2| 0| 0| 7| 0| 0| 0| 0| 4| 0| 0| 0| 0| 9| 2| 4| 0| 0| 8| 6| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy                      |    2                          2                       2                 2|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  2  1  2  3  1  2  2  1  2  3  2  1  2  2  2  2  2  2  2  2  3  2     3|             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
      Vein, Ectasia                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +|  46        |
      Parasite Metazoan                    |             X                    X              X                        |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A|  47        |
      Parasite Metazoan                    |                                           X                 X        X   |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  M  +  +  +  +  +|  43        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  I  +  +  +  A  +  +  I  +  +  A  A  +  +  A  +  +  +  +  +  A  A|  40        |
      Hyperplasia, Lymphoid                |    2                                                     2               |      3  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A|  38        |
      Hyperplasia, Lymphoid                |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             1                                      1           2         |      7  1.4|
      Basophilic Focus                     | 1  1        1     2  1  1                             1  1  1  1  1      |     22  1.0|
      Clear Cell Focus                     |                                                                1         |      1  1.0|
      Congestion                           |                                              3                           |      1  3.0|
      Degeneration, Fatty                  |       2  2        1                    1           2                    1|     11  1.5|
      Eosinophilic Focus                   |                   1                                                      |      2  1.0|
      Hematopoietic Cell Proliferation     | 1                                                                        |      1  1.0|
      Hepatodiaphragmatic Nodule           | X  X        X     X  X                    X           X           X  X   |     11     |
      Inflammation, Focal, Granulomatous   | 1           1  1  1                 1     1  2  1  1  1     2  1  1     1|     28  1.2|
      Leukocytosis                         | 2                                                                        |      1  2.0|
      Necrosis                             |       1  2                    2  1                                       |      9  1.3|
      Thrombosis                           |                         1                                                |      1  1.0|
      Bile Duct, Hyperplasia               |                      1        1              1                 1         |      8  1.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 1     1                       1  1                          1            |     10  1.3|
      Acinus, Inflammation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |             1     1     1        1              1     1     1  1         |     13  1.0|
      Duct, Hyperplasia                    |             1  1  1     2  1     1  1           1  1  1        1  1  1  1|     25  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 4        3                                                               |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                | 2        2                                                               |      5  2.4|
      Epithelium, Hyperplasia              | 4        3                    2                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                2                                                         |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            |                                                                      2   |      1  2.0|
      Ulcer                                |                      3                                                   |      3  2.0|
      Epithelium, Hyperplasia              |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  2  2     1  1  2  2  1  2  1  2  2  1  1  1  2  1  1  2  2  3  2  2  2|     49  1.7|
      Atrium, Inflammation                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Degeneration, Fatty                  | 1  1  2     1  1  1     2  2     3  1           1              1         |     29  1.6|
      Ectopic Tissue                       |                                  X                                       |      1     |
      Focal Cellular Change                |                   1                             1        1        1      |      8  1.1|
      Hematopoietic Cell Proliferation     | 1                          1        2                    1               |     10  1.3|
      Hyperplasia                          |                   1                                                      |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  I  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  44        |
      Hyperplasia                          |    2              1           2                                1         |      8  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  I|  43        |
      Hyperplasia                          |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |             2                                                            |      1  2.0|
      Pars Distalis, Hyperplasia           |          3                    3        2                    3     3     1|      7  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                            1                                             |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      2  1.5|
      Hyperplasia                          |                                                                4         |      2  3.5|
      Inflammation, Suppurative            |                                                 1        2     2         |      7  1.4|
      Duct, Hyperplasia                    |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2              2                                                         |      4  2.0|
      Cyst                                 | 2  1           1           1                                             |      6  1.7|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           | 2                                   2                                    |      2  2.0|
      Hemorrhage                           |                                                          3               |      2  3.5|
      Hyperplasia, Cystic                  |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Cellular                   |                                                                          |      1  3.0|
      Hyperplasia, Neutrophil              |                               2                                          |      2  2.5|
      Myelofibrosis                        |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Hyperplasia                          | 1           1              1                             1  1            |     10  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |    2        2  2           1                 1           2  1     2      |     19  1.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                      3     2  2                                          |      5  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                   3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Degeneration, Cystic                 |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Galactocele                          |                                              1                           |      1  1.0|
      Hyperplasia                          |    2        2              2  1                 1  2     1               |     11  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |    2              2                                               2      |      6  2.3|
      Periosteum, Proliferation            | 1  1        1     1     1        1  1        1        2     1            |     18  1.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                        2                             2   |      3  2.3|
      Hydrocephalus                        | 1                                                                        |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    1        1  1        1           2           1     2  1  2  1     1   |     22  1.3|
      Metaplasia, Squamous                 |                      1                                                   |      2  1.5|
      Epithelium, Hyperplasia              |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           4                          4   |      3  3.3|
      Hemorrhage                           |             2  1        1     1                                          |      8  1.4|
      Inflammation, Chronic, Focal         | 1  1  2     2     2        1     1  1           1     2  2  2  2  1      |     32  1.3|
      Inflammation, Focal, Granulomatous   |                   1                                   1                  |      2  1.0|
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                         3                                      2         |      5  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1     1     1     1     1        1  1                 1  1     1         |     20  1.1|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                | 1           1  1  2        1                 1  1        1  1     1      |     23  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 2  2  2     3  2  4     2  2  2  2  2  2  2  2  2  2  3  3  2  2  3  2  1|     48  2.3|
      Inflammation, Suppurative            | 1  1  1  2  1  2  1     1  1  1  2  2  2  1  1  2  2  2  1  1  2  2  1   |     47  1.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                    1                     |      7  1.6|
      Olfactory Epithelium, Degeneration   | 2  2        2     1     1           3     1  2  1     2                  |     23  1.7|
      Olfactory Epithelium, Metaplasia     | 1  2        2           1           1     2           1                  |     15  1.5|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                     3                                    |      3  2.0|
      Respiratory Epithelium, Hyperplasia  | 2  3  3  1  2  1  2     2  2  2  2  1  1  2  2     3  3  2  1  3  2  2  3|     46  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 1| 5| 2| 3| 5| 0| 5| 1| 5| 5| 4| 5| 5| 4| 2| 6| 5| 9| 5| 5| 5| 5| 5| 6| 3|            |
                                           | 6| 0| 2| 6| 0| 5| 0| 9| 0| 0| 1| 0| 0| 8| 4| 0| 0| 9| 0| 0| 0| 0| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 4  3  3  1  3  1  4  4  3  3  3  3  3  4  3  4  4  3  3  1     2  2  3  3|     49  3.1|
      Submucosa, Hyperplasia               |                         1  1                                   1         |      5  1.2|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                          1  1  1         |     12  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|  48        |
      Inflammation, Suppurative            |                               1                                          |      3  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Synechia                             |                   3           1                                          |      3  2.3|
      Cornea, Hyperplasia                  |                                                                          |      1  2.0|
      Cornea, Inflammation, Suppurative    |                               1                                         1|      3  2.0|
      Lens, Degeneration                   |                   4  2                    1                          3   |      5  2.8|
      Lens, Mineralization                 |                   3                                                      |      2  2.5|
      Retina, Degeneration                 |                   3        1     2                                       |      6  2.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   1        |
      Metaplasia, Squamous                 |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                   +        +                             +               |   7        |
      Acinus, Atrophy                      |                   2        2                             2               |      7  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 3  2  2  1  2  2  2  2  2  3  1  2  2     2  2  2  2  2  1  2  2  2  1  1|     48  1.9|
      Renal Tubule, Hyperplasia            |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Transitional Epithelium, Hyperplasia |                               3                                          |      1  3.0|
      Vein, Ectasia                        |                                                                      2   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  I  +  +  +  +  +  I  +  +  +  +  +  +  I  +  +  A  +  +  +  A  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                            1                                             |             
      Parasite Metazoan                    |                                                             X        X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                     X        X  X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  A  +  +  +|             
      Inflammation, Suppurative            |                            3                                             |             
      Parasite Metazoan                    |    X                                            X     X                  |             
      Ulcer                                |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  A  +  A  +  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Basophilic Focus                     |    1  1  1     1                 1                                      2|             
      Clear Cell Focus                     |    X  3        3                                1                        |             
      Degeneration, Cystic                 |                                                                   1      |             
      Degeneration, Fatty                  |          1              3  3        3              1  2  4     4  3      |             
      Degeneration                         |                                        2  3  2                           |             
      Hematopoietic Cell Proliferation     |                                                                      1   |             
      Hepatodiaphragmatic Nodule           |                   X           X                             X            |             
      Inflammation, Focal, Granulomatous   |    1  1                       1                    1                 1   |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |             2           1  3                             2     2         |             
      Thrombosis                           |                                                                2         |             
      Bile Duct, Hyperplasia               | 2  1  2  1  2  1  2  1     1  1  1  1  2  1  3  2        1  2  2  1     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                                            +      |             
      Fat, Inflammation, Chronic           |                      3                                                   |             
      Fat, Necrosis                        |                   3  1                                            4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Acinus, Atrophy                      | 1  1        2  2  2              1        2     1              2  2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    1  1  1  1                                               1           1|             
      Duct, Hyperplasia                    |    1  1     1        1                       1                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |          4              3  2        3                 2                 3|             
      Inflammation, Suppurative            |                                                                1         |             
      Ulcer                                |          3              2  3        3                 2        2        1|             
      Epithelium, Hyperplasia              |          4              3  3        3                 3                 4|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Eosinophil    |                                                                          |             
      Inflammation, Chronic                |                               2                                          |             
      Inflammation, Suppurative            |          1                 2              3           2  2     2         |             
      Mineralization                       |                   4                                               4  3   |             
      Ulcer                                |                            3        1     3           2  2     2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                               +  +   |             
      Mineralization                       |                   3                                               3  3   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  2  2  3  3  2  3  2  2  2  1  2  2  1  2  2  1  2  2  2  2  2  2  3  3|             
      Mineralization                       |                   2                                                      |             
      Atrium, Thrombosis                   |                                              3           2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2     2           2  2  2              2           1  2  1  1        2|             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                      1                                                   |             
      Hyperplasia                          |                   3                       1                              |             
      Hypertrophy                          |                                                                2         |             
      Necrosis                             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          | 1  1           4  2     2  2     2        3     2        1               |             
      Necrosis                             |                                     3                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1        1        2                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Hyperplasia                          |                                                                   4      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |       3        2     2                          3                        |             
      Pars Distalis, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1              3                             2               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             3            |             
      Inflammation, Suppurative            | 1  1                    2                                   1        2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |          3  2  1        1  2     2                    3  1     3  3     2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +                                      +  +  +     +            |             
      Inflammation, Suppurative            |          3                                      1  1  3                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2     2  4     1  3                                4        4  4     4|             
      Necrosis                             |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                        1  1                    1         |             
      Perivascular, Inflammation           |          2                                                              2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |       2                                                                  |             
      Hyperplasia, Neutrophil              |                                                                          |             
      Myelofibrosis                        |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Mesenteric, Inflammation, Focal,     |                                                                          |             
           Granulomatous                   |                                                                      3   |             
      Mesenteric, Pigmentation, Hemosiderin|                                                          2               |             
      Renal, Congestion                    |                            3                                             |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Pigmentation, Hemosiderin            |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2  2  2     2                                2  2           2  3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis                             |                                  3                             2         |             
      Hematopoietic Cell Proliferation     |                                                                      3   |             
      Necrosis                             |                         2           4                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  +  M  +  +  M  +  +  M  +  M  M  M  M  +  +  +  M  +  +  M  +|             
      Galactocele                          |                   1  1                             1           1  2      |             
      Hyperplasia                          |             2                                         2  2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               2                                          |             
      Ulcer                                |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   2                                   2           3  3   |             
      Periosteum, Proliferation            |                                                                   2  1   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
      Inflammation, Suppurative            |                                                                          |             
      Meninges, Pigmentation, Hemosiderin  |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1     1     1  1  1     1        1        1           2     1  1        2|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    3                     |             
      Hemorrhage                           |             1           1                                                |             
      Inflammation, Chronic, Focal         | 1           2                                1        1                  |             
      Inflammation, Focal, Granulomatous   |                      1                                                   |             
      Mineralization                       |                   2                                               1      |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             2        1                                                   |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Mononuclear Cell                |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |    2  1  1     1                 1              1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  2           1        1     3  2              1     1     2     2  2  1|             
      Inflammation, Suppurative            | 2  1  1  1  1  1  2  2  1  1  1  1  1  1  1  1     1  1  2  1  2     1  1|             
      Thrombosis                           |                   3  3     2           1  2  2           4     3         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 1  3     2        2        1                       2     2     2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 6| 5| 7| 5| 7| 7| 6| 7| 7| 5| 7|             
                             DAY ON TEST   | 7| 4| 4| 4| 4| 4| 3| 4| 7| 0| 7| 4| 9| 3| 6| 5| 4| 6| 4| 0| 7| 4| 4| 8| 4|             
                                           | 1| 9| 9| 9| 9| 9| 2| 9| 4| 2| 1| 9| 9| 0| 6| 3| 9| 9| 9| 2| 4| 7| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Degeneration   |                                                                   2      |             
      Olfactory Epithelium, Metaplasia     | 2                       1                                                |             
      Respiratory Epithelium, Hyperplasia  |                   2     1                                1  1     3  1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                   1     1                                         1  1   |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     | 1  1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                   2                                               1      |             
      Cornea, Degeneration                 |                                                                      2   |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Cornea, Mineralization               |                   2                                               1      |             
      Lens, Degeneration                   |                                                 2        1               |             
      Lids, Inflammation, Suppurative      |                   1                                                      |             
      Retina, Degeneration                 |                                                          3               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                   +           +     +  +     +         |             
      Inflammation, Suppurative            | 1                                   1           1     1        1         |             
      Metaplasia, Squamous                 |                                                                          |             
      Acinus, Hyperplasia                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                             +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Mineralization                       |                   3                                                      |             
      Nephropathy                          | 2  3  3  4  3  3  4  2  2  3  1  3  2  2  2  2  3  2  4  3  3  2  4  4  3|             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                       2                  |             
      Transitional Epithelium, Hyperplasia |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  44        |
      Hemorrhage                           |                         3                                                |      1  3.0|
      Inflammation, Suppurative            |                         3                                                |      2  2.0|
      Parasite Metazoan                    |       X                                                              X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Parasite Metazoan                    | X           X                                                            |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      3     |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  A  +  +  +  +|  42        |
      Hyperplasia, Lymphoid                | 2        2        2  2  2              2              2           2      |      9  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  A  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  1                                2      |      3  1.7|
      Basophilic Focus                     | 1     1  2  1  1     1           1     1              1  1        2      |     17  1.2|
      Clear Cell Focus                     | 2        1  2  1                                                  3      |      9  2.0|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Degeneration, Fatty                  | 2                       1           1     2        3           3        3|     16  2.4|
      Degeneration                         |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |             X                    X                 X              X      |      7     |
      Inflammation, Focal, Granulomatous   | 2        1  2              1           1        2              1  1  1   |     14  1.2|
      Leukocytosis                         |          1     1                 1              2        X               |      5  1.3|
      Necrosis                             |                               1                    2           1         |      8  1.8|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1  1  1  1  2  1  1  1     1  3  1     1  2  2     1     1  1        1  1|     40  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +     +            |   5        |
      Fat, Inflammation, Chronic           |                                                             3            |      2  3.0|
      Fat, Necrosis                        |                                                       2     3            |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                       4                  |      1  4.0|
      Acinus, Atrophy                      | 1     1        1  3  3  1           1  1  1           2        1  1      |     22  1.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                          +               |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Inflammation, Suppurative            | 1  1                    1        1        1              1               |     12  1.0|
      Duct, Hyperplasia                    | 1  1  1     1  1  1  1                 2  1              1               |     15  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                            2     4  2           2  2           3        2|     13  2.6|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Ulcer                                |                            2     4              3  1                    3|     12  2.4|
      Epithelium, Hyperplasia              |                            2     3  1           2  4           4        1|     13  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Eosinophil    |                                     2                                    |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                         2                          2                     |      8  2.0|
      Mineralization                       |                            2                                             |      4  3.3|
      Ulcer                                |                         2                          3                     |      8  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   3        |
      Mineralization                       |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  1  2  2  2  3  3  2  2  2  2  1  2  2  2        2  2  1     3  2  1|     47  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                         1                                                |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  | 2  1        2  2  1        2     2  1     2  2        2                  |     22  1.7|
      Focal Cellular Change                |                1                    1     1                              |      3  1.0|
      Hematopoietic Cell Proliferation     |       1  1                             1        1                 1      |      6  1.0|
      Hyperplasia                          |                                        2                          2      |      4  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  M  +  +  +  +  +  M  +  M  M|  42        |
      Hyperplasia                          |             3        1     2  2  3                                       |     15  2.1|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  I|  42        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                            3                                             |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                              X                           |      1     |
      Pars Distalis, Hemorrhage            |                         3                                                |      1  3.0|
      Pars Distalis, Hyperplasia           |       4           2  4     2           4     2                    2  4   |     12  2.8|
      Pars Distalis, Inflammation,         |                                                                          |            |
          Suppurative                      |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |    1     1                                   4                    2  1   |      8  1.9|
      Follicular Cell, Hyperplasia         |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | M  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                      X   |      2  3.0|
      Inflammation, Suppurative            |                            2                 1     1     1               |      9  1.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1              2                    1                 1        1     1|      6  1.2|
      Inflammation, Suppurative            |                         2  1  3  3  1  1        1  1  1  1     1     1   |     23  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                       +     +            |   7        |
      Inflammation, Suppurative            |                                                       2     2            |      6  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            4  3  4           4                 2         |     14  3.2|
      Necrosis                             |                                                    4                     |      1  4.0|
      Interstitial Cell, Hyperplasia       |                1        1                             1                  |      6  1.0|
      Perivascular, Inflammation           | 1                                2                    2                  |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |                                                                          |      1  2.0|
      Hyperplasia, Neutrophil              |                      3                                                   |      1  3.0|
      Myelofibrosis                        |                               1                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Plasma Cell             |                                                          3               |      1  3.0|
      Mesenteric, Inflammation, Focal,     |                                                                          |            |
           Granulomatous                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric, Pigmentation, Hemosiderin|                                                                          |      1  2.0|
      Renal, Congestion                    |                                                                          |      1  3.0|
      Renal, Hyperplasia                   |    2                                                              2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      2           2  1                    2     2         |      5  1.8|
      Inflammation, Focal, Granulomatous   |             2                                                            |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Hyperplasia                          | 2        2        2  2                 2  2     2  2     3     2  2  2   |     21  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Tissue                       |                            X                                             |      1     |
      Fibrosis                             |                               2                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Necrosis                             |                                                    2                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  +  +  M  +  M  M  +  M  M  M  M  M  M  +  M  M  +  +  M|  21        |
      Galactocele                          |    1                       2                                             |      7  1.3|
      Hyperplasia                          |                   1  1                                   1               |      6  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                            X                                             |      5  2.5|
      Periosteum, Proliferation            |             1                                                            |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                         2                                                |      2  2.0|
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
      Meninges, Pigmentation, Hemosiderin  |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Inflammation, Suppurative            | 2              1  1  2  2        1     1              1  1              1|     22  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                               1                                          |      3  1.0|
      Inflammation, Chronic, Focal         |             2  1              2     1     2  1        1  2              3|     13  1.5|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |             1                             2           1  2               |      5  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                               2                                          |      3  1.7|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Mononuclear Cell                | 2                                                                        |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                | 1        1  2  1        1        2  2  1        1        2     3  1      |     18  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         | 3     1     3  3     2  1  1  1  1     1     1        2  2     2  2  2   |     28  1.7|
      Inflammation, Suppurative            | 3  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1     1  1  1  1  1  1  1|     46  1.2|
      Thrombosis                           |                                  1                 3        1            |     11  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                         2  2        2  2     2     2        2  1        1|     17  1.8|
      Olfactory Epithelium, Degeneration   |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  1.5|
      Respiratory Epithelium, Hyperplasia  | 2        1  1        1     1                             1               |     12  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      4  1.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                        2                                 |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |          1                                                               |      2  1.0|
      Epithelium, Hyperplasia              |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                            3                                             |      3  2.0|
      Cornea, Degeneration                 |                                                                          |      1  2.0|
      Cornea, Inflammation, Suppurative    |                         2  3                                             |      2  2.5|
      Cornea, Mineralization               |                                                                          |      2  1.5|
      Lens, Degeneration                   |                            3                                             |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 6| 5| 4| 5| 7| 7| 5| 5| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 4| 4| 6| 4| 5| 0| 3| 6| 4| 4| 2| 1| 4| 4| 2|            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 3| 9| 5| 8| 8| 7| 9| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lids, Inflammation, Suppurative      |                                                                          |      1  1.0|
      Retina, Degeneration                 |                   2                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                         +|   7        |
      Inflammation, Suppurative            |                                                                          |      5  1.0|
      Metaplasia, Squamous                 |                                                                         1|      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                      2                                                   |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy                          | 3  3  3  3  3  2  3  2  1  4  3  3  1  3  3  2  2  1  3  3  2  3  3  3  1|     50  2.6|
      Pelvis, Epithelium, Hyperplasia      |                               3                                          |      1  3.0|
      Renal Tubule, Hyperplasia            | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +  A     +        A  +        +  +  +     +           +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Parasite Metazoan                    |       X  X                             X        X              X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M     +  +     +        +  +        +  +  +     +           +  A  M  +  +|             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     I  +     +        +  +        +  I  +     +           +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +  A     +        A  +        A  +  +     +           +  A  +  +  I|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A     +  A     +        A  +        A  +  +     +           +  A  +  A  I|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1                 1                           |             
      Basophilic Focus                     |    1        1                    X           1                           |             
      Clear Cell Focus                     |                                              1                           |             
      Degeneration, Cystic                 |             2  1                 1                                       |             
      Degeneration, Fatty                  |       1        2           1  1        1  2     1  2  2     1     2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X                                      X                              |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Focal, Granulomatous   |    1        1                 1  1     2                 1               |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |       1        1        2                             1     1        1   |             
      Bile Duct, Hyperplasia               | 1  1  2  2     2     1  2        1              2     2     2        2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Inflammation, Chronic           |                                  2                                       |             
      Fat, Necrosis                        |                                  4                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Acinus, Atrophy                      |          2     1        2           1                       1        1   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Inflammation, Suppurative            |                                           1                       1      |             
      Duct, Hyperplasia                    |                         1           1     1     1           1  1     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Inflammation, Chronic                | 2                          3              4                       2     2|             
      Ulcer                                | 1                          4              4                             1|             
      Epithelium, Hyperplasia              | 3                          4              3                       2     2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                            2              3                              |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |                2        1                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                1                          3                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +     +  +        +  +  +     +           +  +  +  +  +|             
      Cardiomyopathy                       | 2     2  2     1  2     2  1        2  1  3     2           2  3  1  2  2|             
      Atrium, Congestion                   |                   2                                                      |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    3        1  1  1        2  1  1  2     1        3  1           1  1  1|             
      Focal Cellular Change                |             1                                                            |             
      Hematopoietic Cell Proliferation     |             2                                1           1               |             
      Hyperplasia                          |                                                             1            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Hyperplasia                          |       2           1                          2        1                 1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +        +  +        +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +     +        +  +        +  +  +     +           +  +  +  +  M|             
      Hyperplasia                          |                            3                                      2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                4                                                         |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2                    2              2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      C-Cell, Hyperplasia                  |    1              1                                                      |             
      Follicular Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Suppurative            | 1  1                                                              1      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |    3     1                 2        1  1  2                 1  2  2  1  4|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +                                                     +|             
      Dilatation                           |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                         2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Atrophy                              |                                              2  3  4     2  3        3  4|             
      Interstitial Cell, Hyperplasia       |       1  2     1                                   1                     |             
      Perivascular, Inflammation           |    2                          2                                          |             
      Tunic, Hyperplasia                   |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Myelofibrosis                        |       3                                         2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +        +  +        +  +  +     +  +        +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Inflammation, Focal,     |                                                                          |             
           Granulomatous                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +     +  +     +        +  +        +  +  I     +           +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  I     M        +  +        M  +  +     +           +  +  M  +  M|             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Fibrosis                             |             2                       2                 2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |                                                                         4|             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I     +  +     +        M  +        +  +  +     +           +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     M  M     M        +  M        M  +  +     M           M  M  M  M  M|             
      Galactocele                          |                         4              X                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                         4              3                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Epidermis, Hyperplasia               |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Periosteum, Proliferation            |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +        +  +        +  +  +     +           +  +  +  +  +|             
      Hemorrhage                           | 3                                                                        |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | A     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
      Inflammation, Suppurative            |          1                 1        1     1     1           2     1  1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Congestion                           |                                                                   3      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |                   1     2     1                          1              1|             
      Alveolar Epithelium, Hyperplasia     |             3                                                     2     1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          3           2                                2                 1|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |    1        1     1           1  1           1           1              1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                              4                           |             
      Inflammation                         |    2           1  2           2  1  1        1     1     1        2      |             
      Inflammation, Suppurative            |    1  1  1  1  1  2  1  2  2  1  1  1  1  1  1  2  1  1  1  2     2  1  1|             
      Thrombosis                           |                2        1                       2     1     2            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    1        2  1                          2        1  1           1      |             
      Olfactory Epithelium, Degeneration   |                1                                                         |             
      Olfactory Epithelium, Metaplasia     |                   1                 2                                    |             
      Respiratory Epithelium, Hyperplasia  |                1  2                                1        2            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                         2                 1  1                    1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
      Inflammation, Suppurative            |                1                                                  1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                 +              +                     |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                    2                     |             
      Lens, Degeneration                   |                   3                                4                     |             
      Retina, Degeneration                 |                   3                                4                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +     +     +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 5| 7| 6| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 5| 3| 8| 5| 3| 5| 5| 9| 1| 5| 5| 6| 5| 3| 5| 0| 5| 5| 5| 0| 7| 4| 7| 0|             
                                           | 0| 2| 1| 6| 2| 9| 2| 2| 8| 4| 2| 2| 7| 3| 0| 2| 2| 2| 2| 2| 2| 8| 8| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    .075 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 1  3  2  2     2  3  3  1  4  3  3  2  2  4     2     1     2  2  4  2  3|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
      Renal Tubule, Hyperplasia            |                   1  1                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     +        +  +        +  +  +     +           +  A  +  +  +|             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                1                                                  2      |             
      Transitional Epithelium, Hyperplasia |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +     +        +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  M  +  +  +  +     I     +  +     +  +  +  I     +        +|  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  M  +  +     +     +  +     +  +  +  +     +        +|  32        |
      Parasite Metazoan                    |    X                                      X                              |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +     +        +|  30        |
      Parasite Metazoan                    |                                                                X         |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     I     +  +     +  +  +  +     +        +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     I     +  +     +  +  +  +     +        +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  A  A  M  I  +  +  +     I     +  +     +  +  +  +     +        +|  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  M  +  A  A  +  +  +     I     +  A     +  +  +  A     A        A|  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                               3     1                       2            |      5  1.6|
      Basophilic Focus                     |                                           2  1                       2   |      7  1.3|
      Clear Cell Focus                     |                                                             1            |      2  1.0|
      Degeneration, Cystic                 |                            2                       1        2  1         |      7  1.4|
      Degeneration, Fatty                  |    1  2  1  1     1     1     1  3     3           2     2     1        1|     24  1.5|
      Hematopoietic Cell Proliferation     |                                           1                              |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                  X           X                 X         |      5     |
      Hyperplasia                          |                      1                                                   |      1  1.0|
      Inflammation, Focal, Granulomatous   |          1     1           2                 1  2  1                 1   |     13  1.2|
      Leukocytosis                         |                                                 2                        |      1  2.0|
      Necrosis                             | 2              2                                      1           2      |     10  1.4|
      Bile Duct, Hyperplasia               | 2  1  1     1  1  2  2  2  1     2  2  2     1        1  2  1  1     1  2|     32  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                            +                           |   3        |
      Fat, Inflammation, Chronic           |                                                                          |      1  2.0|
      Fat, Necrosis                        | 2                                                                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Acinus, Atrophy                      |                   1     2                 2        1                     |     10  1.4|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                +                                                         |   1        |
      Palate, Inflammation, Chronic        |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Inflammation, Suppurative            |                                        1  1        1                    1|      6  1.0|
      Duct, Hyperplasia                    |       1  1  1                    1     1  1     1     1        1         |     16  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Inflammation, Chronic                |             3              3     2                 2                     |      9  2.6|
      Ulcer                                |             3              3                       2                     |      7  2.6|
      Epithelium, Hyperplasia              |             3              3     3     2        2  1                     |     11  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  32        |
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Inflammation, Chronic                |             1                          3           2                     |      5  2.2|
      Inflammation, Suppurative            |                   1        2     2                       1               |      4  1.5|
      Pigmentation, Hemosiderin            |                                                          1               |      3  1.3|
      Ulcer                                |    1           2  1        3     2     3           2                     |      9  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
      Inflammation, Chronic                |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +  +  +        +|  35        |
      Cardiomyopathy                       | 2  2  2  2  2  1        2  2     1     2  1     2  2  1  2  3  2        1|     34  1.8|
      Atrium, Congestion                   |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |             1     1  3  1  1        1  2     2  1  2     1     1         |     26  1.4|
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                               2                                   1      |      5  1.4|
      Hyperplasia                          |                               2           4                              |      3  2.3|
      Necrosis                             |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |    3        2        2     2  1  2  4     1  1     2     2  2     2     1|     19  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  36        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +  +     +  +     +  +  +  +     +        +|  32        |
      Hyperplasia                          |             2           1                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +  +     +     +  +|  43        |
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |                X                                                         |      1     |
      Pars Distalis, Hyperplasia           |          2     2                                                         |      5  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          1                                   1                    2      |      5  1.2|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +     +  +     +     +  +     +  +  M  +     +        +|  32        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Inflammation, Suppurative            | 2  2     4     1           1                                             |      8  1.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  34        |
      Hyperplasia                          |                                                          1               |      1  1.0|
      Inflammation, Suppurative            |    2        3  1        1  3     2     3           3  1                 2|     21  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                      +   |   3        |
      Dilatation                           |                                                                      3   |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              | 3           3           4  3           3                    2           4|     14  3.1|
      Interstitial Cell, Hyperplasia       |    1           1                    1           2     1              1   |     10  1.2|
      Perivascular, Inflammation           |                                                                          |      2  2.0|
      Tunic, Hyperplasia                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Myelofibrosis                        |    2                             3                                       |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +     +  +     +     +  +  +  +  +  +  +     +        +|  35        |
      Mediastinal, Congestion              |                            4                                             |      1  4.0|
      Mesenteric, Angiectasis              |                                              2                           |      1  2.0|
      Mesenteric, Inflammation, Focal,     |                                                                          |            |
           Granulomatous                   |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  M  +  M  +     +  +     +     +  +     +  +  +  +     +        +|  29        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +     +     +  +     +  M  +  +     +        +|  27        |
      Hyperplasia                          |                2                       2  2           2        2         |      6  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                         2     2              2                           |      6  2.0|
      Hematopoietic Cell Proliferation     |                                           2                              |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Necrosis                             |                                        2                                 |      1  2.0|
      Pigmentation, Hemosiderin            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  M  +     +  +     +     +  +     +  +  +  +     +        M|  26        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M     M  +     +     M        M  +  +  +     M        +|  10        |
      Galactocele                          |    1                                               1     1              1|      6  1.6|
      Hyperplasia                          |                            4                                             |      1  4.0|
      Inflammation, Chronic                |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +     +  +     +     +  +     +  +  +  +     +        +|  32        |
      Epidermis, Hyperplasia               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Fibrous Osteodystrophy               |             1              1                                             |      2  1.0|
      Periosteum, Proliferation            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  33        |
      Hemorrhage                           |                   2                                                      |      2  2.5|
      Necrosis                             |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | A  +  +  +  +  +  +     +  +     +     +  +     +  +  +  +     +        +|  30        |
      Inflammation, Suppurative            |    1  2     1     2     1              1  1     1        1     1        2|     19  1.2|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                               3                                          |      2  3.0|
      Hemorrhage                           |                                                          2               |      1  2.0|
      Inflammation, Chronic, Focal         | 1                 1              3           1           2              2|     11  1.5|
      Alveolar Epithelium, Hyperplasia     |                                  1                                      1|      5  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   2     4        2                       2              1|      9  2.1|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |             1                 1           1  1                           |     12  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Adenomatous             |                                                                          |      1  4.0|
      Inflammation                         |          1     2           1        2  1  3  2           1  1            |     19  1.5|
      Inflammation, Suppurative            | 1  2     2  1  2  2  1  1  2  1  2  1  2  1  1        1  2  1  1  1  1  2|     45  1.3|
      Thrombosis                           |                         1        3     3                 3              3|     10  2.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             1     2  1                 1              2  1              2|     14  1.4|
      Olfactory Epithelium, Degeneration   |    2     1           2                                                   |      4  1.5|
      Olfactory Epithelium, Metaplasia     |    2                 2                                                   |      4  1.8|
      Respiratory Epithelium, Hyperplasia  |                1        1        1  2  1                 1  1            |     11  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                1  1     2              2                                1|      5  1.4|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     | 1        1                                               2               |      7  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 5| 6| 7| 4| 7| 7| 6| 7| 7| 6| 7| 7| 5| 7| 6| 7| 4| 7| 7| 6| 7| 7| 6|            |
                             DAY ON TEST   | 1| 6| 7| 8| 3| 3| 2| 5| 6| 3| 5| 8| 5| 4| 7| 5| 5| 2| 8| 4| 5| 6| 5| 5| 9|            |
                                           | 1| 7| 1| 7| 2| 1| 8| 2| 7| 7| 2| 7| 2| 4| 1| 2| 5| 4| 5| 1| 2| 7| 2| 2| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    .075 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | A  +  +  +  +  +  +     I  +     +     +  +     +  +  +  +     +        I|  29        |
      Inflammation, Suppurative            |                                        1                                 |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                   +              +   |   6        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                       3                  |      1  3.0|
      Cornea, Inflammation, Suppurative    |                   1                                   3                  |      3  2.0|
      Lens, Degeneration                   |                                                                      3   |      3  3.3|
      Retina, Degeneration                 |                                                                      3   |      3  3.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +|  44        |
      Hydronephrosis                       |                                     1                                    |      1  1.0|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                      2     1                                             |      2  1.5|
      Mineralization                       |                                        2                                 |      1  2.0|
      Nephropathy                          | 2  2  2  2  4  1  3  4  2  4  3  2  3  3  1  3  3  2  1  2     3        1|     43  2.4|
      Pigmentation, Hemosiderin            | 2                                                                        |      1  2.0|
      Pelvis, Epithelium, Hyperplasia      |                            2        1                                    |      2  1.5|
      Renal Tubule, Hyperplasia            |             1              2  2     1                                    |      6  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +     I     +  +     +  +  +  +     +        +|  31        |
      Inflammation                         |                                                                2         |      1  2.0|
      Inflammation, Suppurative            |                            1                                             |      3  1.3|
      Transitional Epithelium, Hyperplasia |                            1                                             |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +        +        +           +     +     +  +  M  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +        A        +           +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | I  +  +     +  +  +        M        +           +     I     +  +  +  A  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +        A        +           +     +     +  +  +  +  +|             
      Parasite Metazoan                    |                                                                      X  X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +        A        +           +     +     +  +  +  A  I|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +        +        +           +     +     I  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A     +  +  +        A        +           +     I     +  +  +  A  I|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  A     A  +  +        A        I           +     I     +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2  1     1           1  2     1                     |             
      Basophilic Focus                     |       2                          1        2        1     1  1            |             
      Clear Cell Focus                     |                      1                                                   |             
      Degeneration, Cystic                 |                               2                             1            |             
      Degeneration, Fatty                  |             2           1                             2  2        2     1|             
      Degeneration                         |                                        2                                 |             
      Hematopoietic Cell Proliferation     |                         1                                2  1            |             
      Hepatodiaphragmatic Nodule           |       X                                                     X        X   |             
      Hyperplasia                          |                      1              1                                    |             
      Inflammation, Focal, Granulomatous   |                   2  1                       1     1        1            |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |                                                       2  1              2|             
      Bile Duct, Hyperplasia               | 1  1  1  1  2  2     1  2     2        2  1  1     1  2              2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +        M        +           A     +     +  +  +  +  +|             
      Thrombosis                           |             2                                                            |             
      Acinus, Atrophy                      |    2  3     1     1                                                  1   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Inflammation, Suppurative            |                1                    1                 1                  |             
      Duct, Hyperplasia                    |                1  1                                   1     1           1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Inflammation, Chronic                |                                     2                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  2     1  2  1        1        2           2     2     2  1  1  2  2|             
      Mineralization                       |                                                                          |             
      Atrium, Congestion                   |                                                                          |             
      Atrium, Thrombosis                   |                                                       3           2     1|             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |       2     1     2  1  1     1  1                 1        1  1         |             
      Focal Cellular Change                |                                  2                                       |             
      Hematopoietic Cell Proliferation     |          1           1                             1                     |             
      Hyperplasia                          |                         2     2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     1     3  1              2  1        3  2                       2   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +        M     +  +           A     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
      Thrombosis                           |                3                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +        +     +  +     +  +  A     +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |             X                                                            |             
      Pars Distalis, Hemorrhage            |                                                       3                  |             
      Pars Distalis, Hyperplasia           | 4              2                    2                                2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                      1  1        1  1        1                           |             
      Follicular Cell, Hyperplasia         |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  +        +        +           +     +     +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            | 2           1           1     1  1                 1     1              2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            | 2  1        3  2  2        2                          3     1        1  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +                                                                  |             
      Dilatation                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  3  2  3  1           3           1     1              4               |             
      Interstitial Cell, Hyperplasia       | 1           3  3  1        1                                             |             
      Perivascular, Inflammation           |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Myelofibrosis                        |                                                                      4   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +        +  +     +  +        +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
      Fibrosis                             |                                                                      2   |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2                 4     2                                      2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Necrosis                             |                                                                   1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     M  +  +        +        +           A     M     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +     M  +  +        +        +           M     M     M  M  +  M  M|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |    2  2                             2                             1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +        +        +     +     +     +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                         X|             
      Subcutaneous Tissue, Fibrosis        |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +        +        +           +     +     +  +  +  +  +|             
      Hemorrhage                           | 3                          2        3           3                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +  +        A        +           A     +     +  +  +  +  +|             
      Inflammation                         |                                                             2            |             
      Inflammation, Suppurative            |       1     1     2                 2                 1           2     2|             
      Metaplasia, Squamous                 |                                                                          |             
      Epithelium, Hyperplasia              |                                                             2            |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Chronic, Focal         |    1     1  2        1        1  2                 1        3            |             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                         3|             
      Alveolar Epithelium, Hyperplasia     |             1  1                                      2                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1                                   2                    3  1         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |       1              1  1        1        1  1     1     1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2        1  2  1     1           1  1     1     1  2        1  2|             
      Inflammation, Suppurative            | 1     1  1  2  2  1  1  1  2  1  1  1  1  1  1  1  1  1     1  1  2  1  2|             
      Thrombosis                           |             3                          2              3           3     2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2              2                    2                    1     1     2|             
      Olfactory Epithelium, Degeneration   |          2                                                           1   |             
      Olfactory Epithelium, Metaplasia     | 1                                            1              1           2|             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |    1                                                        2        2  1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2  1                             1  1                             1  3|             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                     1     1                 1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 5| 7| 7| 3| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 6| 4| 6| 6| 6|             
                             DAY ON TEST   | 7| 0| 0| 5| 1| 6| 9| 5| 5| 8| 5| 5| 9| 5| 5| 5| 8| 5| 3| 5| 8| 3| 6| 9| 6|             
                                           | 7| 2| 2| 1| 4| 7| 2| 1| 1| 9| 1| 1| 9| 1| 1| 1| 8| 1| 6| 1| 7| 9| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.25 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +                                                         |             
      Synechia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  +     +  +        A     +     +  +  +  +  +|             
      Cyst                                 |                         X                                         X      |             
      Hemorrhage                           |                                     4                                    |             
      Inflammation, Suppurative            |                                        2                                 |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  4  2     2  2  2  3  4  1  3     2  4              2     4  3  2  2  2|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +        +        +           A     +     +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +     +  +     +  +     +           +  +     +  +  +     +|  28        |
      Inflammation, Suppurative            |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A        A  +     +  +     A  +     +           +  +     A  +  +     +|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A        A  +     +  +     A  +     +           +  +     A  +  +     +|  21        |
      Parasite Metazoan                    |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A        A  +     +  +     A  +     +           +  +     A  +  +     +|  24        |
      Parasite Metazoan                    |                                                                         X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A        M  +     +  +     A  +     +           M  M     M  +  +     +|  20        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A        A  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A        A  +     +  +     +  +     M           I  +     +  +  +     I|  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A        A  +     +  +     A  +     A           I  I     +  +  +     +|  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A        A  +     I  +     A  A     +           +  I     A  +  I     I|  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       1                                         1                        |      8  1.3|
      Basophilic Focus                     |                                     1     1  1  X                        |     10  1.2|
      Clear Cell Focus                     |       1                             1                                    |      3  1.0|
      Degeneration, Cystic                 |          1        2              1                          1  2         |      7  1.4|
      Degeneration, Fatty                  |                   1     2                             2        2     2   |     11  1.7|
      Degeneration                         |                      2                                                   |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                          1        2      |      5  1.4|
      Hepatodiaphragmatic Nodule           |                                        X        X           X  X         |      7     |
      Hyperplasia                          |                                                                          |      2  1.0|
      Inflammation, Focal, Granulomatous   |          1                             1        1                        |      8  1.1|
      Leukocytosis                         |                                              1                           |      1  1.0|
      Necrosis                             |             2           1     1  1           1     1     1              1|     11  1.3|
      Bile Duct, Hyperplasia               |       1        1  1  2     1     2  1  1  2  1  1  2  2  1              2|     31  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                      +                                 |   2        |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Fat, Inflammation, Chronic           |                                        4                                 |      1  4.0|
      Fat, Necrosis                        |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  26        |
      Thrombosis                           |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                         1              1                    1           2|      9  1.4|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                +                                               +         |   2        |
      Palate, Inflammation                 |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
      Inflammation, Suppurative            |                      1                                      1            |      5  1.0|
      Duct, Hyperplasia                    |                      1  1              1              1                  |      9  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    A        +  +     +  +     +  +     +           +  +     +  +  +  +  +|  28        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    A        +  +     +  +     +  +     +           +  +     +  +  +  +  +|  28        |
      Inflammation, Chronic                |                         2                                      3         |      3  2.3|
      Inflammation, Suppurative            |                3                                                         |      1  3.0|
      Mineralization                       |                               2                                          |      1  2.0|
      Ulcer                                |                2                                               3         |      2  2.5|
      Epithelium, Hyperplasia              |                         2     1                                3         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    A        +  +     +  +     +  +     +           +  +     +  +  +  +  +|  28        |
      Ectopic Tissue                       |                                  X                                       |      1     |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
      Mineralization                       |                               3                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                  1                                       |      1  1.0|
      Ulcer                                |                                  1                                   3   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +                                          |   1        |
      Mineralization                       |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +     +  +     +  +     +  +        +  +     +  +  +     +|  30        |
      Cardiomyopathy                       |    1        2  1     1  3     3  2     2  2        2  2     2  2  1     1|     30  1.8|
      Mineralization                       |                               3                                          |      1  3.0|
      Atrium, Congestion                   |                                           3                              |      1  3.0|
      Atrium, Thrombosis                   |                               3                    2                     |      5  2.2|
      Ventricle, Thrombosis                |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Degeneration, Fatty                  | 1                       2  2  2  1        2           2     2     1  1  1|     21  1.4|
      Focal Cellular Change                |                                           2                              |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                          1               |      4  1.0|
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          | 2                          3  2  3     3              2     2     2  1  2|     20  2.1|
      Necrosis                             |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +        +  +     +  M     +  +     +           +  +     +  +  +     +|  27        |
      Hyperplasia                          |                               4                                1         |      3  2.3|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +     +     +     +  +  +  +  +  +  +  +|  40        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                      X           X                                       |      3     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                1              3  3                 3              2      |      9  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Hyperplasia                  |                   1     1           1           2  3                     |     10  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    M        +  +     I  +     +  +     +           +  +     +  +  +     +|  26        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                             +            |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  A  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                         X|      1     |
      Inflammation, Suppurative            |                   1  1        2           1     1     1                  |     14  1.2|
                                            __________________________________________________________________________|____________|
   Prostate                                |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
      Hyperplasia                          |                                                                   1      |      1  1.0|
      Inflammation, Suppurative            |                                                    4        3  1  1      |     14  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                               +        +     +              +            |   6        |
      Dilatation                           |                                              3              3            |      2  3.0|
      Inflammation, Suppurative            |                               2                             2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2                 2           4        2  3                 3        4  4|     17  2.6|
      Interstitial Cell, Hyperplasia       |                      1  1     2              2                       1  1|     11  1.5|
      Perivascular, Inflammation           |                   2           3                                      1   |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    A        A  +     +  +     +  +     +           +  +     +  +  +     +|  26        |
      Myelofibrosis                        |                                                    4                     |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  A        +  +     +  +     +  +     +           +  +     +  +  +     +|  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    M        +  M     +  +     +  +     +           +  +     +  +  +     +|  25        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                             1            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  28        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                     2     2        1                     |      7  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                   2      |      1  2.0|
      Inflammation, Granulomatous          |                                                 1                        |      1  1.0|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M        +  +     +  +     +  +     +           +  +     +  +  +     +|  25        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M        +  M     M  M     M  M     +           M  +     +  M  M     +|  12        |
      Galactocele                          |                                        2              2                  |      2  2.0|
      Hyperplasia                          |             1                                               1            |      6  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  30        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +     +  +     +  +     +           +  +     +  +  +     +|  29        |
      Fibrous Osteodystrophy               |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +     +  +  +  +  +     +           +  +     +  +  +     +|  30        |
      Hemorrhage                           |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    A        +  +     +  +     +  +     +           +  +     A  +  +     +|  25        |
      Inflammation                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                1        1     1        2              1                 1|     13  1.4|
      Metaplasia, Squamous                 |                               1                                          |      1  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                              3              4            |      2  3.5|
      Edema                                |    1                                                                     |      1  1.0|
      Hemorrhage                           |                1              2                                          |      3  1.7|
      Inflammation, Chronic, Focal         |       1           1  2              1           1        1               |     14  1.4|
      Mineralization                       |                               2                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                  1                                       |      4  1.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                            1  2                                          |      6  1.7|
      Perivascular, Infiltration Cellular, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 6| 5| 7| 5| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 5|            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 2| 5| 2| 7| 5| 4| 6| 5| 3| 5| 5| 5| 0| 4| 5| 8| 3| 9| 5| 7|            |
                                           | 1| 2| 1| 1| 0| 9| 1| 9| 4| 1| 5| 7| 1| 6| 1| 1| 1| 2| 1| 1| 7| 0| 2| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.25 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Mononuclear Cell                | 1     1  1        1                 1     1  1  1        2     1  1      |     19  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 1     1              2        3     1     1  1  1     1  2  1     2      |     24  1.4|
      Inflammation, Suppurative            | 1     1  1     1  1  2  1  1  1  2  1  2  1  1  1  1  1  1  1  2  1  1  1|     46  1.2|
      Thrombosis                           |             3           2        1                 2                     |      9  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       1        1        1  1              2  2        1              2   |     14  1.5|
      Olfactory Epithelium, Degeneration   |                                                 1                        |      3  1.3|
      Olfactory Epithelium, Metaplasia     |                      1     1        2           1     2           2      |     10  1.4|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                   1                                                      |      1  1.0|
      Respiratory Epithelium, Hyperplasia  |             1        2  1     2                       1  2  1  1         |     12  1.4|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      6  1.5|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                               1  1                          1            |      6  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    A        +  +     +  +     +  +     +           +  +     A  +  +     +|  26        |
      Inflammation, Suppurative            |                1                                                         |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +           +         |   4        |
      Synechia                             |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +     +     +  +     +  +  +  +  +|  39        |
      Cyst                                 |                                                                          |      2     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                             2            |      2  2.0|
      Mineralization                       |                               3                                          |      1  3.0|
      Nephropathy                          | 4  1     2  2  2  4  1  3  3  4  2  3  2     2     3  2     4  4  2  4  1|     39  2.6|
      Papilla, Necrosis                    |                                                             3            |      1  3.0|
      Renal Tubule, Hyperplasia            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    A        +  +     +  +     +  +     +           +  +     +  +  +     +|  27        |
      Calculus Gross Observation           |             X                                                            |      1     |
      Calculus Micro Observation Only      |             X                                                            |      1     |
      Hemorrhage                           |                                                             3            |      2  2.5|
      Inflammation, Suppurative            |                      4                             1        3  1         |      4  2.3|
      Transitional Epithelium, Hyperplasia |                      3                                                   |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  A|             
      Parasite Metazoan                    |                            X  X     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                      X                             X              X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
      Hyperplasia, Lymphoid                |    2                    2        2        2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | M  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus                     |    1              1     1  2     1  1     1        1                 1   |             
      Clear Cell Focus                     |                                     1     1                              |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |          1                                                               |             
      Degeneration, Fatty                  |       1  1  1  3     2                          3                        |             
      Eosinophilic Focus                   |                                        X                                 |             
      Hematopoietic Cell Proliferation     |                                                 2                 1      |             
      Hepatodiaphragmatic Nodule           |                X           X     X                                       |             
      Inflammation, Focal, Granulomatous   |    1                             1                 1                    1|             
      Leukocytosis                         |                                                             2            |             
      Necrosis                             | 2                                                                 1      |             
      Bile Duct, Hyperplasia               | 2  1     1              1  1     1  1  1     1  1  1  1  1           1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Inflammation, Chronic           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 3  1              2     1                       1                    1   |             
      Acinus, Necrosis                     |                                                       1                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |    +                                                                     |             
      Palate, Cyst                         |                                                                          |             
      Palate, Developmental Malformation   |    2                                                                     |             
      Palate, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         1  1        1                 1  1           1   |             
      Duct, Hyperplasia                    |             1              1     1  2              1  1  1           1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       3  4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |       3  4                                                               |             
      Epithelium, Hyperplasia              |       3  4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                 2                        |             
      Ulcer                                |                1                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  3  1  2  2  1  2  2  1  2  2  2  3  2  3  2  2  2  2  1     1  1  2  3|             
      Atrium, Thrombosis                   | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1        2        1  3  1                    2  2        1  2     1  1   |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |    1                       2  1  1  1                    1     3     3   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  I  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2  2                    2        3                             3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4           4                    2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  I  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                      2     4        2                                    |             
      Pars Intermedia, Hyperplasia         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               2                 4                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  +  M|             
                                            __________________________________________________________________________|             
   Penis                                   |                      +                                                   |             
      Inflammation, Suppurative            |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Suppurative            |       1                                            1     2        1      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                            3         |             
      Inflammation, Suppurative            |       2     3        1        1                                1         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +     +                 +                                       |             
      Dilatation                           |                                                                          |             
      Inflammation, Suppurative            |       1  2     1                 3                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   3     3  3     4              4  4              3      |             
      Interstitial Cell, Hyperplasia       |       1                                         1     1           1      |             
      Perivascular, Inflammation           |       2                          2              1                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                    2              2                        |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1        2        2     2           2     2     2  2  2     3            |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2  2                                             |             
      Hematopoietic Cell Proliferation     |                                                 2           2     3      |             
      Inflammation, Granulomatous          |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Necrosis                             |                            4                          3                  |             
      Thrombosis                           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  +  A  M  M  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  M  +  +  M  +  M  +  +  M  M  M  +  +  +  +  +  M  +  M  +  M|             
      Galactocele                          |                4  1              3              1     2                  |             
      Hyperplasia                          |                         1                    1     2     2     3         |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Fibrous Osteodystrophy               |                                                 2                        |             
      Periosteum, Proliferation            |    1  1  1              1                       2                       1|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                1                             4              1            |             
      Hydrocephalus                        |                                                                          |             
      Meninges, Thrombosis                 |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1  1  1        1     1        2  1           1     1                 2   |             
      Metaplasia, Squamous                 |                                                                1     1   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3           3              3                       3           3|             
      Hemorrhage                           |                1           2                             1               |             
      Inflammation, Chronic, Focal         | 2           2                                                           1|             
      Alveolar Epithelium, Hyperplasia     |                                     1     3                             1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         1                 1     3                       1|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |    2  1  1  2     2  2  2     2  1  1     1        1     1  1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    1                                                                     |             
      Inflammation                         | 2  2  3  3  4  3  2  2  3  3  3  3  2     3  3  2  3     1  3  4  3  3  3|             
      Inflammation, Suppurative            | 2  1  1  1  2  2  1  2  2  2  2  2  1     2  2  2  2     1  1  2  2  2  1|             
      Thrombosis                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    1  1  2  2     2     2                                               2|             
      Olfactory Epithelium, Degeneration   | 1  2  2  3     2  1  2     1  1     1        1  3  2           2        1|             
      Olfactory Epithelium, Metaplasia     |    1     1                                      2              2         |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |          2                          1           3  1                     |             
      Respiratory Epithelium, Hyperplasia  | 3  2  3  3  3  2  2  2  3  3  3  3  2     3  2  3  3  2  1  3  3  2  3  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 4  4  4  4  4  2  2  4  2  3  3  3  4  1  3  4  4  3        3  3  3  3  4|             
      Submucosa, Hyperplasia               |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |          1                                            1           1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 6| 7| 6| 7| 6|             
                             DAY ON TEST   | 9| 5| 6| 1| 7| 5| 5| 7| 5| 5| 5| 5| 5| 6| 5| 1| 6| 5| 3| 5| 2| 5| 0| 5| 5|             
                                           | 4| 0| 0| 4| 4| 0| 0| 1| 0| 0| 0| 0| 0| 2| 0| 4| 7| 0| 8| 0| 5| 0| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.75 MG/                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Synechia                             |             2                                                            |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |          1                                                               |             
      Cornea, Degeneration                 |                                                 2                        |             
      Cornea, Inflammation, Suppurative    |                                                 3                        |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Degeneration                   |                                                                          |             
      Retina, Degeneration                 |             2                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          2                                      2                        |             
      Nephropathy                          | 2  3  3  4  2  2  2  3  3  3  3  3  3  2  3  1  4  3  2  3  2  2  1  4  3|             
      Pelvis, Epithelium, Hyperplasia      |                                                    2                     |             
      Renal Tubule, Hyperplasia            |                                                                2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2                                                               |             
      Transitional Epithelium, Hyperplasia |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Parasite Metazoan                    |                X              X                 X                        |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |    X           X                       X        X                    X   |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Parasite Metazoan                    |                            X                    X                        |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  I  +  +  +  +  +|  43        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  +  +  +  A  A  +  +  M  +  +  +  +  +  +  +  +  +|  39        |
      Parasite Metazoan                    |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                     2                 1                  |      3  1.3|
      Basophilic Focus                     |    1  1     X  1  1  1     1  3     1  2     1     1  1                 1|     23  1.2|
      Clear Cell Focus                     |       2              1                                                   |      4  1.3|
      Congestion                           |                                                             3            |      1  3.0|
      Degeneration, Cystic                 |                                                          1        1      |      3  1.0|
      Degeneration, Fatty                  | 1  1           1                                                     1   |     10  1.5|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                            1                    2  1                     |      5  1.4|
      Hepatodiaphragmatic Nodule           |    X              X                    X           X     X     X         |      9     |
      Inflammation, Focal, Granulomatous   |          1              1  1                       1                     |      8  1.0|
      Leukocytosis                         |                                                                          |      1  2.0|
      Necrosis                             |    2  1        1     1              3                                    |      7  1.6|
      Bile Duct, Hyperplasia               |    2  2  1     2  1  1  1     1  1  1  2                 1     1  1  2  1|     31  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +              +        +                           |   4        |
      Fat, Inflammation, Chronic           |                      2                       2                           |      2  2.0|
      Fat, Necrosis                        |                      2                       2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy                      |             2  1           3                    1     1  2  2  1        1|     15  1.5|
      Acinus, Necrosis                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                     +  +              +                  |   4        |
      Palate, Cyst                         |                                        2                                 |      1  2.0|
      Palate, Developmental Malformation   |                                     2                                    |      2  2.0|
      Palate, Inflammation, Chronic        |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |       1                          2  1              1  1     1  1         |     13  1.1|
      Duct, Hyperplasia                    |                         1  1        1        1     1  1     1  2         |     16  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 3                                                                        |      3  3.3|
      Inflammation, Suppurative            |          2                                                               |      1  2.0|
      Ulcer                                | 3        2                                                               |      4  3.0|
      Epithelium, Hyperplasia              | 4        2                                                               |      4  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                       2  1               |      2  1.5|
      Inflammation, Suppurative            |                                     2                                    |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                | 2                                   2                                    |      3  1.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  2  2  2  1  2     1  1  1  2  2  2  2  3  2  3|     48  1.9|
      Atrium, Thrombosis                   |                3                                1                        |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  | 1  1  2        1  2                 2  1     2        2     2  2  2     2|     24  1.6|
      Focal Cellular Change                |                         1     1                                          |      2  1.0|
      Hematopoietic Cell Proliferation     |       1     3        1  1  1                                1  2  2      |     16  1.6|
      Hyperplasia                          |             2              4                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +|  38        |
      Hematopoietic Cell Proliferation     |       1                                                                  |      1  1.0|
      Hyperplasia                          | 2     3        2  2  1  1  2     1              2     1        2  2      |     17  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|  41        |
      Hyperplasia                          | 3                                                                 2      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                           X                              |      1     |
      Pars Distalis, Hemorrhage            |                                  2                                       |      1  2.0|
      Pars Distalis, Hyperplasia           |    2        2  2              2  2     2                    3     3  2   |     12  2.3|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 2  2              1  1  1                          2  2                  |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  M  +  +  +  +  +  +  +  I  +  +  +  +  +  M  M  +  +  +  +  +  I  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    3                     |      1  3.0|
      Hyperplasia, Squamous                |                                     3                                    |      1  3.0|
      Inflammation, Suppurative            |             1              1                          1     1        2  1|     10  1.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |             1        1  1     1                       1     1  4  1      |     10  1.5|
      Inflammation, Suppurative            | 3     2     1     2     1  3  2  1     2     1  1  1  1                  |     18  1.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +     +                 +     +                              |   8        |
      Dilatation                           |                   2                                                      |      1  2.0|
      Inflammation, Suppurative            |             1                             1                              |      6  1.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 4  3     4  4                             2  4        1                  |     14  3.3|
      Interstitial Cell, Hyperplasia       |                   1                                                     1|      6  1.0|
      Perivascular, Inflammation           | 1                                                     2                 2|      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |                         1  2                                             |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Hyperplasia                          |                         2  2  2                 2     2                  |      8  1.9|
      Inflammation, Focal, Granulomatous   |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Hyperplasia                          | 2     3  2     2  2        2                    2              2         |     18  2.1|
      Inflammation, Focal, Granulomatous   |          2  1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 3           1  2  3                    3              2  2     3         |     10  2.3|
      Hematopoietic Cell Proliferation     | 2                                   3           2  3                     |      7  2.4|
      Inflammation, Granulomatous          |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Osseous                  |                                        2                                 |      1  2.0|
      Necrosis                             |                                                                          |      2  3.5|
      Thrombosis                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  M  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  M  M  M  M  M  +  M  +  +  M  +  +  M  +  M  +  I  +  M  +|  24        |
      Galactocele                          |                                              1        3                 1|      8  2.0|
      Hyperplasia                          | 2                                               1           2            |      8  1.8|
      Inflammation, Chronic                |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               | 1                                                                        |      2  1.5|
      Periosteum, Proliferation            |    1                 1                 2     2        1     1     1  1  2|     15  1.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      3  2.0|
      Hydrocephalus                        |                                              2                           |      1  2.0|
      Meninges, Thrombosis                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            | 1  1        1  1     1  1     1  1     2  1  1                 1         |     22  1.1|
      Metaplasia, Squamous                 |                                           1                              |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      5  3.0|
      Hemorrhage                           | 1              2                                                         |      5  1.4|
      Inflammation, Chronic, Focal         |       2     1                                1  1     1        1         |      9  1.3|
      Alveolar Epithelium, Hyperplasia     |             1           2  1                 1                           |      7  1.4|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   1                                   1  1     1         |      8  1.3|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                | 1        1        2        1  2              2     1           1  2     1|     24  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation                         | 3  2  3  3  2  3  1  3  3  3  1  2  1  3  2  2  1  2  2  3  3  3  3  2  3|     48  2.5|
      Inflammation, Suppurative            | 2  1  1  2  2  2  1  2  1  1  1  2  2  2  1  1     1  1  2  2  2  1  2  2|     47  1.6|
      Thrombosis                           |                                                 1                        |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1     2        1                             1     1  2                  |     14  1.6|
      Olfactory Epithelium, Degeneration   | 2     1  1           2  1              2     2        2  1  1     2     2|     27  1.6|
      Olfactory Epithelium, Metaplasia     |                      2           1     2     2        2  1  2     2     3|     13  1.8|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                        2                                3|      6  2.0|
      Respiratory Epithelium, Hyperplasia  | 3  2  2  2  3  3  1  2  2  3  2  3  2  4  2  2     1  3  3  2  3  2  3  3|     48  2.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 3  2  4  3  3  4     4  3  2  1  3  3  4     3        2  3  3  2  4  3  3|     44  3.1|
      Submucosa, Hyperplasia               |                                  2                 1                 2   |      3  1.7|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     | 2        1                          1              1                 1   |      8  1.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  I  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |          1     2     1                          1                        |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                           4                              |      1  4.0|
      Synechia                             |    1                                                                     |      2  1.5|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                        1                                1|      3  1.0|
      Cornea, Degeneration                 | 2                                                                        |      2  2.0|
      Cornea, Inflammation, Suppurative    | 2                                   2  1                                 |      4  2.0|
      Cornea, Mineralization               | 2                                   1                                    |      2  1.5|
      Lens, Degeneration                   |          1                          4                                    |      2  2.5|
      Retina, Degeneration                 |                                     4                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Nephropathy                          | 4  2  2  2  3  2  3  2  2  3  3  2  3  2  1  3  1  2  3  1  3  3  4  2  3|     50  2.5|
      Pelvis, Epithelium, Hyperplasia      |                                                                          |      1  2.0|
      Renal Tubule, Hyperplasia            |                                                       3           3      |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05096-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                 O-CHLOROBENZALMALONONITRILE (CS-2)                            Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:41:21  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 5| 6| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 5| 4| 5| 4| 5| 9| 5| 5| 5| 5| 5| 8| 3| 3| 7| 3| 2| 1| 5| 7| 5| 5| 5| 2| 5|            |
                                           | 0| 1| 0| 2| 0| 4| 0| 0| 0| 0| 0| 1| 3| 2| 3| 9| 2| 2| 0| 7| 0| 0| 0| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    0.75 MG/                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M3                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                             4            |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
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