TDMS Study 05096-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05096 0-CHLOROBENZALMALONONITRILE (CS-2) TIME: 02:14:39
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55118
CONT: N01-ES-38061 CAS: 2698-41-1
PATHOLOGIST: R. MILLER
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05096 0-CHLOROBENZALMALONONITRILE (CS-2) TIME: 02:14:39
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55118
CONT: N01-ES-38061 CAS: 2698-41-1
PATHOLOGIST: R. MILLER
0-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 749 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 438 463 508 515 529 529 553 567 569 571 |
| 571 585 612 630 655 666 674 674 699 702 |
| 702 732 739 747 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .075 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 431 485 553 560 571 571 586 598 631 639 |
| 648 655 667 667 667 667 674 678 687 687 |
| 690 702 702 702 711 714 724 728 730 732 |
| 737 741 744 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 389 439 452 529 529 536 571 577 588 592 |
| 592 599 620 641 660 667 667 667 674 687 |
| 687 698 702 702 702 714 730 736 745 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
0-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 749 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.75 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 24 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 473 522 571 577 581 606 612 625 625 638 |
| 641 655 660 662 667 674 694 694 714 714 |
| 732 733 739 742 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
0-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 749 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 749 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 96.0 88.0 76.0 70.0 52.0 |
| | |
| | |
|.075 MG/M3 | 100.0 100.0 100.0 100.0 100.0 96.0 96.0 84.0 76.0 34.0 |
| | |
| | |
|0.25 MG/M3 | 100.0 100.0 100.0 100.0 98.0 94.0 88.0 76.0 70.0 42.0 |
| | |
| | |
|0.75 MG/M3 | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 72.0 52.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL .075 MG/M3 0.25 MG/M3 0.75 MG/M|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.0% 34.0% 42.0% 52.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.396N P=0.247 P=0.509 P=0.909N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 609.6 656.9 623.9 648.0 |
|NATURAL DEATHS (C) | (18.2) (13.2) (17.3) (14.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.1 688.2 676.4 700.5 |
|(STANDARD ERROR) | (13.2) (10.7) (13.3) ( 9.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
0-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 749 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 465 487 507 543 561 563 567 576 583 588 |
| 589 601 606 616 641 641 652 666 667 667 |
| 668 679 681 694 702 714 714 718 724 745 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = .075 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 438 445 466 508 519 527 568 571 571 584 |
| 601 602 602 612 666 687 690 694 702 714 |
| 715 717 720 729 730 737 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 370 457 465 536 546 549 563 571 591 606 |
| 617 631 639 658 680 690 691 709 732 739 |
| 744 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
0-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 749 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.75 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 476 505 522 536 578 584 599 606 624 633 |
| 633 634 639 641 648 660 660 662 667 694 |
| 702 716 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
0-CHLOROBENZALMALONONITRILE (CS-2)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 749 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 749 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 76.0 66.0 40.0 |
| | |
| | |
|.075 MG/M3 | 100.0 100.0 100.0 100.0 100.0 94.0 88.0 74.0 72.0 48.0 |
| | |
| | |
|0.25 MG/M3 | 100.0 100.0 100.0 100.0 98.0 94.0 92.0 82.0 72.0 58.0 |
| | |
| | |
|0.75 MG/M3 | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 86.0 64.0 54.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL .075 MG/M3 0.25 MG/M3 0.75 MG/M|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 40.0% 48.0% 58.0% 54.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.327N P=0.482N P=0.128N P=0.265N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 627.5 619.8 608.8 623.4 |
|NATURAL DEATHS (C) | (13.5) (18.7) (21.8) (13.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 676.1 681.8 690.1 691.2 |
|(STANDARD ERROR) | (11.7) (13.3) (13.4) (10.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
0-CHLOROBENZALMALONONITRILE (CS-2)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
.075 MG/M3 = 2
0.25 MG/M3 = 3
0.75 MG/M3 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 21 4
| 3 21 14 2 4
| 3 3 1 2 11 43 22 44
| 1 1 2 2
90 + 33 4 4
| 13 1 2 2 44
P | 1 1132 2 4 42
E | 3 3 422
R 80 + 22
C | 1 1 33 422
E | 1 3 131 3 2 42
N | 1 3 1 34
T 70 + 1 314
| 11 4
S | 31 21 4
U | 3 311
R 60 + 4 4
V | 231 1
I | 33 111
V | 22 41
A 50 + 33
L | 2 2 3
| 2 233
| 3
40 + 22
|
| 22
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 38 obs hidden.
0-CHLOROBENZALMALONONITRILE (CS-2)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
.075 MG/M3 = 2
0.25 MG/M3 = 3
0.75 MG/M3 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 3 2 14
| 3 22 314 1 4
96 + 2 32 1 1 4
| 2 1 4 31
| 2 2 31 1 4
| 22 33 44
P 88 + 2 3 32 4 4
E | 131 44
R | 311 3 4 4
C | 2 2 3 3 44
E 80 + 1 123 3
N | 11 3 3
T | 11 33
| 211 3 3
S 72 + 1 143 2 3
U | 4 42 32
R | 1 1
V | 1 1 22 3
I 64 + 44 223 3
V | 4 422 33
A | 4422 33
L | 11 4 4 3
56 + 11
| 1 1 2 2 4
| 11
| 11 22
48 + 22
| 11
| 11
| 1 1
40 + 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 20 obs hidden.
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