TDMS Study 05097-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) ALPHA-CHLOROACETOPHENONE NTP Experiment-Test: 05097-02 Report: PEIRPT03 Study Type: CHRONIC Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 Facility: Battelle Northwest Chemical CAS #: 532-27-4 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Moribund 8 13 10 Dead 2 9 8 Survivors Terminal Sacrifice 40 27 32 Dead 1 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (49) (49) (48) Epithelium, Hyperplasia, Focal 1 (2%) Gallbladder (45) (33) (39) Inflammation, Suppurative 2 (6%) Intestine Large, Cecum (49) (41) (42) Hyperplasia, Lymphoid 1 (2%) Ulcer, Multifocal 1 (2%) Intestine Small, Duodenum (48) (43) (41) Ulcer 1 (2%) Intestine Small, Ileum (50) (45) (43) Amyloid Deposition 3 (6%) 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Liver (50) (49) (49) Cyst 1 (2%) Cytomegaly 1 (2%) Inflammation, Chronic, Multifocal 2 (4%) 3 (6%) 1 (2%) Inflammation, Suppurative 1 (2%) Necrosis 1 (2%) Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%) Serosa, Inflammation, Suppurative 1 (2%) Vein, Thrombosis 1 (2%) Mesentery (16) (13) (19) Hyperplasia, Lymphoid 1 (6%) 2 (11%) Inflammation, Chronic 2 (13%) 1 (8%) 2 (11%) Inflammation, Suppurative 2 (15%) Fat, Necrosis 1 (8%) Vein, Thrombosis 1 (8%) Pancreas (50) (48) (48) Amyloid Deposition, Focal 1 (2%) Atrophy 2 (4%) 2 (4%) 2 (4%) Cyst 1 (2%) 1 (2%) Degeneration, Focal 1 (2%) Fibrosis, Focal 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Hyperplasia, Lymphoid 1 (2%) Inflammation, Chronic 1 (2%) Inflammation, Suppurative 1 (2%) Necrosis, Coagulative 1 (2%) Salivary Glands (50) (50) (48) Hyperplasia, Lymphoid 1 (2%) Inflammation, Chronic, Multifocal 2 (4%) Duct, Hyperplasia 1 (2%) Stomach, Forestomach (49) (48) (48) Developmental Malformation 1 (2%) Hyperkeratosis 1 (2%) Hyperplasia, Squamous 2 (4%) 6 (13%) Inflammation, Chronic 1 (2%) Stomach, Glandular (50) (47) (48) Atrophy 1 (2%) Cyst 1 (2%) Tooth (2) Dysplasia 1 (50%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (49) (49) Aorta, Inflammation, Chronic 1 (2%) Heart (50) (50) (49) Amyloid Deposition, Multifocal 1 (2%) Atrium, Inflammation, Suppurative 1 (2%) Atrium, Thrombosis 2 (4%) Myocardium, Fibrosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (46) (48) Subcapsular, Hyperplasia 49 (98%) 42 (91%) 46 (96%) Adrenal Gland, Cortex (46) (44) (46) Amyloid Deposition 1 (2%) Cyst 2 (4%) Degeneration 41 (89%) 39 (89%) 37 (80%) Fibrosis 37 (80%) 23 (52%) 36 (78%) Focal Cellular Change 1 (2%) Adrenal Gland, Medulla (44) (38) (39) Amyloid Deposition 1 (3%) Degeneration 1 (2%) Hyperplasia 1 (2%) Hyperplasia, Focal 1 (2%) Pituitary Gland (45) (43) (45) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Distalis, Cyst 1 (2%) Pars Distalis, Hyperplasia 11 (24%) 10 (23%) 13 (29%) Thyroid Gland (49) (46) (49) Inflammation, Chronic 1 (2%) C-Cell, Hyperplasia 3 (6%) 1 (2%) Follicle, Cyst 2 (4%) 1 (2%) Follicular Cell, Hyperplasia 8 (16%) 6 (13%) 11 (22%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (44) (45) Abscess 1 (2%) 1 (2%) Cyst 22 (44%) 15 (34%) 14 (31%) Inflammation, Chronic 5 (11%) 2 (4%) Inflammation, Suppurative 1 (2%) Uterus (50) (49) (49) Congestion 1 (2%) Inflammation, Necrotizing 1 (2%) 2 (4%) 3 (6%) Endometrium, Hyperplasia, Cystic 35 (70%) 35 (71%) 28 (57%) Endometrium, Metaplasia, Squamous 2 (4%) Lumen, Dilatation 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) (49) Sternal, Hyperplasia 1 (2%) Sternal, Myelofibrosis 21 (42%) 19 (40%) 18 (37%) Lymph Node (50) (48) (46) Mediastinal, Hyperplasia, Lymphoid 1 (2%) Mediastinal, Inflammation, Chronic 1 (2%) Mesenteric, Abscess 1 (2%) Mesenteric, Hyperplasia, Lymphoid 1 (2%) Lymph Node, Bronchial (26) (38) (36) Amyloid Deposition 1 (3%) Hemorrhage, Acute 1 (3%) Hyperplasia, Lymphoid 3 (12%) 1 (3%) 1 (3%) Inflammation, Chronic 1 (3%) Lymph Node, Mandibular (45) (41) (40) Hemorrhage, Acute 1 (2%) 1 (2%) Hyperplasia, Lymphoid 5 (11%) 5 (12%) 4 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Spleen (50) (48) (49) Amyloid Deposition 1 (2%) Atrophy 1 (2%) Congestion 1 (2%) Hematopoietic Cell Proliferation 4 (8%) 8 (17%) 3 (6%) Hyperplasia, Lymphoid 3 (6%) 6 (13%) 6 (12%) Necrosis 1 (2%) Pigmentation, Hemosiderin 2 (4%) Capsule, Inflammation, Chronic 1 (2%) Capsule, Inflammation, Suppurative 1 (2%) Thymus (42) (37) (35) Amyloid Deposition 1 (3%) Inflammation, Chronic, Diffuse 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (39) (37) (39) Inflammation, Chronic 1 (3%) Duct, Dilatation 1 (3%) Skin (50) (50) (48) Ulcer 1 (2%) 1 (2%) Hair Follicle, Atrophy 5 (10%) 8 (16%) 7 (15%) Subcutaneous Tissue, Inflammation, Subacute 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (48) (50) Cranium, Developmental Malformation 1 (2%) Skeletal Muscle (1) (1) Inflammation, Focal, Suppurative 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (50) Hemorrhage, Acute, Multifocal 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Inflammation, Chronic, Focal 1 (2%) Hypothalamus, Atrophy 4 (8%) 1 (2%) 2 (4%) Thalamus, Atrophy 1 (2%) Thalamus, Mineralization 5 (10%) 12 (24%) 10 (20%) Ventricle, Dilatation 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (47) (49) Epithelium, Erosion 1 (2%) Epithelium, Hyperplasia 1 (2%) Lung (50) (47) (49) Hemorrhage 1 (2%) Hyperplasia, Lymphoid 1 (2%) 3 (6%) Inflammation, Chronic 2 (4%) Inflammation, Chronic, Multifocal 26 (52%) 19 (40%) 18 (37%) Inflammation, Multifocal, Suppurative 1 (2%) Leukocytosis 1 (2%) 2 (4%) Alveolar Epithelium, Hyperplasia 2 (4%) 4 (8%) Alveolus, Amyloid Deposition, Multifocal 1 (2%) Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%) Nose (50) (48) (49) Mucosa, Inflammation, Suppurative 2 (4%) 1 (2%) 3 (6%) Olfactory Epithelium, Cytoplasmic Alteration 1 (2%) Respiratory Epithelium, Hyperplasia 2 (4%) Respiratory Epithelium, Metaplasia, Squamous 4 (8%) Trachea (49) (46) (49) Glands, Cyst 1 (2%) Peritracheal Tissue, Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (47) (42) Sclera, Inflammation, Chronic, Focal 1 (2%) Harderian Gland (1) (1) (1) Hyperplasia 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (48) Amyloid Deposition 1 (2%) 2 (4%) Cyst, Multiple 1 (2%) Hyperplasia, Lymphoid 2 (4%) 1 (2%) Infiltration Cellular, Lymphocyte 2 (4%) 1 (2%) Inflammation, Chronic 4 (8%) 11 (22%) 2 (4%) Nephropathy 1 (2%) 3 (6%) 5 (10%) Renal Tubule, Crystals 1 (2%) Renal Tubule, Cytomegaly 1 (2%) Renal Tubule, Dilatation 2 (4%) 1 (2%) Urinary Bladder (50) (47) (48) Hyperplasia, Lymphoid 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Inflammation, Chronic 7 (14%) 13 (28%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 Early Deaths Dead 5 9 11 Moribund 11 5 6 Survivors Terminal Sacrifice 34 36 33 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Ileum (48) (44) (44) Hyperplasia, Lymphoid 2 (4%) 3 (7%) Liver (50) (48) (49) Cytomegaly 1 (2%) Hematopoietic Cell Proliferation, Multifocal 1 (2%) Infarct 1 (2%) Inflammation, Chronic, Multifocal 1 (2%) 3 (6%) Necrosis 1 (2%) 2 (4%) Sinusoid, Ectasia 1 (2%) Pancreas (50) (45) (47) Atrophy 1 (2%) Pharynx (1) Epithelium, Hyperplasia, Focal 1 (100%) Salivary Glands (50) (48) (49) Hyperplasia, Lymphoid 4 (8%) 6 (12%) Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) Inflammation, Chronic, Multifocal 3 (6%) 1 (2%) 2 (4%) Stomach, Forestomach (49) (46) (45) Congestion 1 (2%) Cyst 1 (2%) 1 (2%) Erosion 1 (2%) Hyperkeratosis 3 (6%) 1 (2%) 2 (4%) Hyperplasia 1 (2%) Hyperplasia, Lymphoid 1 (2%) Hyperplasia, Squamous 1 (2%) 2 (4%) Inflammation, Chronic, Focal 1 (2%) Ulcer, Multiple 1 (2%) Stomach, Glandular (50) (44) (47) Dysplasia 1 (2%) Hyperplasia 1 (2%) 1 (2%) Ulcer, Multiple 2 (4%) Tooth (5) (1) (3) Abscess 3 (60%) 1 (100%) 2 (67%) Developmental Malformation 1 (20%) 1 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Dysplasia 1 (20%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (49) (49) Cardiomyopathy, Focal 1 (2%) Hyperplasia, Lymphoid 1 (2%) Inflammation, Acute 1 (2%) Atrium, Thrombosis 1 (2%) 1 (2%) Myocardium, Necrosis 1 (2%) Valve, Degeneration, Mucoid 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (45) (47) Subcapsular, Hyperplasia 17 (34%) 5 (11%) 6 (13%) Adrenal Gland, Cortex (50) (45) (47) Hyperplasia, Focal 5 (10%) Hypertrophy 1 (2%) Adrenal Gland, Medulla (48) (44) (41) Degeneration, Focal 1 (2%) Pituitary Gland (44) (37) (46) Pars Distalis, Hyperplasia 1 (2%) 1 (3%) 2 (4%) Thyroid Gland (50) (45) (48) Cyst 1 (2%) Follicular Cell, Hyperplasia, Focal 5 (10%) 5 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Penis (1) Inflammation, Suppurative 1 (100%) Preputial Gland (10) (5) (8) Abscess 3 (30%) 3 (38%) Cyst 3 (30%) 3 (60%) 2 (25%) Inflammation 3 (30%) 1 (20%) 2 (25%) Inflammation, Suppurative 1 (20%) Prostate (50) (44) (43) Abscess 2 (4%) 2 (5%) Seminal Vesicle (49) (15) (44) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Dilatation 2 (4%) 2 (5%) Inflammation, Suppurative 1 (2%) 1 (2%) Testes (50) (44) (47) Atrophy 4 (8%) 8 (18%) 4 (9%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (48) (46) (47) Hyperplasia, Lymphoid 1 (2%) Iliac, Hyperplasia, Lymphoid 1 (2%) Iliac, Inflammation, Chronic 1 (2%) Mediastinal, Hyperplasia, Lymphoid 2 (4%) Mesenteric, Autolysis 1 (2%) Mesenteric, Hematopoietic Cell Proliferation 1 (2%) Mesenteric, Hyperplasia, Lymphoid 2 (4%) 3 (6%) Mesenteric, Hyperplasia, Re Cell 1 (2%) Mesenteric, Inflammation, Chronic 2 (4%) Mesenteric, Inflammation, Suppurative 1 (2%) Lymph Node, Bronchial (35) (38) (36) Hyperplasia, Lymphoid 1 (3%) 2 (5%) 4 (11%) Lymph Node, Mandibular (41) (29) (38) Hyperplasia, Lymphoid 6 (15%) 2 (7%) 4 (11%) Infiltration Cellular, Histiocyte 1 (2%) 1 (3%) Inflammation, Chronic 1 (3%) Spleen (50) (47) (49) Ectopic Tissue 2 (4%) Hematopoietic Cell Proliferation 10 (20%) 5 (11%) 5 (10%) Hyperplasia, Lymphoid 3 (6%) 4 (9%) 3 (6%) Inflammation, Acute 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (5) (19) (15) Duct, Cyst 1 (7%) Skin (50) (47) (47) Abscess 1 (2%) Atrophy 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Hair Follicle, Atrophy 1 (2%) 4 (9%) 2 (4%) Prepuce, Inflammation, Suppurative 1 (2%) Prepuce, Ulcer 8 (16%) 1 (2%) Subcutaneous Tissue, Hyperplasia, Lymphoid 1 (2%) Subcutaneous Tissue, Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (49) Coccygeal, Inflammation, Multifocal, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (48) Thalamus, Mineralization 19 (38%) 21 (43%) 9 (19%) Ventricle, Dilatation 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (47) (47) Epithelium, Hyperplasia, Focal 1 (2%) Lung (50) (49) (49) Congestion, Acute 1 (2%) Hyperplasia, Lymphoid 1 (2%) 4 (8%) Infiltration Cellular, Histiocyte 1 (2%) Inflammation, Chronic, Multifocal 21 (42%) 19 (39%) 16 (33%) Inflammation, Suppurative 1 (2%) Leukocytosis 1 (2%) 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 3 (6%) 4 (8%) 1 (2%) Alveolus, Pigmentation, Diffuse 1 (2%) Bronchiole, Hyperplasia 1 (2%) 1 (2%) Venule, Thrombosis 1 (2%) Nose (50) (48) (48) Foreign Body 1 (2%) Glands, Hyperplasia, Focal 1 (2%) Glands, Inflammation, Focal, Suppurative 2 (4%) Mucosa, Inflammation, Suppurative 2 (4%) 2 (4%) Olfactory Epithelium, Atrophy 1 (2%) Respiratory Epithelium, Metaplasia, Squamous 2 (4%) Trachea (50) (46) (47) Glands, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (45) (45) Inflammation, Necrotizing 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (49) Cyst 1 (2%) 3 (6%) Infarct 1 (2%) Infiltration Cellular, Lymphocyte 41 (82%) 38 (78%) 42 (86%) Inflammation, Chronic, Multifocal 1 (2%) Inflammation, Suppurative 2 (4%) 1 (2%) 2 (4%) Nephropathy 6 (12%) 5 (10%) 10 (20%) Pelvis, Dilatation 1 (2%) Pelvis, Inflammation, Suppurative 4 (8%) 1 (2%) Renal Tubule, Hyperplasia, Focal 1 (2%) Renal Tubule, Inflammation, Suppurative 2 (4%) Urinary Bladder (49) (44) (47) Calculus Micro Observation Only 1 (2%) Dilatation 1 (2%) Hyperplasia, Lymphoid 1 (2%) Inflammation, Chronic 5 (10%) 1 (2%) Inflammation, Suppurative 3 (6%) 1 (2%) Lumen, Hemorrhage 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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