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TDMS Study 05097-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                      ALPHA-CHLOROACETOPHENONE


NTP Experiment-Test: 05097-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38




       Facility:  Battelle Northwest

       Chemical CAS #:  532-27-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                           8           13           10                                                  
    Dead                                               2            9            8                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           27           32                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (48)                                                
      Epithelium, Hyperplasia, Focal                                             1 (2%)                                             
   Gallbladder                                        (45)         (33)         (39)                                                
      Inflammation, Suppurative                                     2 (6%)                                                          
   Intestine Large, Cecum                             (49)         (41)         (42)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Ulcer, Multifocal                                                          1 (2%)                                             
   Intestine Small, Duodenum                          (48)         (43)         (41)                                                
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Ileum                             (50)         (45)         (43)                                                
      Amyloid Deposition                               3 (6%)                    1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (50)         (49)         (49)                                                
      Cyst                                                                       1 (2%)                                             
      Cytomegaly                                                                 1 (2%)                                             
      Inflammation, Chronic, Multifocal                2 (4%)       3 (6%)       1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic, Focal     1 (2%)                    1 (2%)                                             
      Serosa, Inflammation, Suppurative                             1 (2%)                                                          
      Vein, Thrombosis                                                           1 (2%)                                             
   Mesentery                                          (16)         (13)         (19)                                                
      Hyperplasia, Lymphoid                            1 (6%)                    2 (11%)                                            
      Inflammation, Chronic                            2 (13%)      1 (8%)       2 (11%)                                            
      Inflammation, Suppurative                                     2 (15%)                                                         
      Fat, Necrosis                                                 1 (8%)                                                          
      Vein, Thrombosis                                              1 (8%)                                                          
   Pancreas                                           (50)         (48)         (48)                                                
      Amyloid Deposition, Focal                                                  1 (2%)                                             
      Atrophy                                          2 (4%)       2 (4%)       2 (4%)                                             
      Cyst                                             1 (2%)       1 (2%)                                                          
      Degeneration, Focal                              1 (2%)                                                                       
      Fibrosis, Focal                                               1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (48)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                             2 (4%)                                                          
      Duct, Hyperplasia                                             1 (2%)                                                          
   Stomach, Forestomach                               (49)         (48)         (48)                                                
      Developmental Malformation                       1 (2%)                                                                       
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Squamous                            2 (4%)                    6 (13%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
   Stomach, Glandular                                 (50)         (47)         (48)                                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
   Tooth                                                                        (2)                                                 
      Dysplasia                                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (49)         (49)                                                
      Aorta, Inflammation, Chronic                     1 (2%)                                                                       
   Heart                                              (50)         (50)         (49)                                                
      Amyloid Deposition, Multifocal                                             1 (2%)                                             
      Atrium, Inflammation, Suppurative                             1 (2%)                                                          
      Atrium, Thrombosis                                            2 (4%)                                                          
      Myocardium, Fibrosis                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (46)         (48)                                                
      Subcapsular, Hyperplasia                        49 (98%)     42 (91%)     46 (96%)                                            
   Adrenal Gland, Cortex                              (46)         (44)         (46)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Cyst                                                                       2 (4%)                                             
      Degeneration                                    41 (89%)     39 (89%)     37 (80%)                                            
      Fibrosis                                        37 (80%)     23 (52%)     36 (78%)                                            
      Focal Cellular Change                                         1 (2%)                                                          
   Adrenal Gland, Medulla                             (44)         (38)         (39)                                                
      Amyloid Deposition                                                         1 (3%)                                             
      Degeneration                                     1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (45)         (43)         (45)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                                                        1 (2%)                                             
      Pars Distalis, Hyperplasia                      11 (24%)     10 (23%)     13 (29%)                                            
   Thyroid Gland                                      (49)         (46)         (49)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      C-Cell, Hyperplasia                              3 (6%)       1 (2%)                                                          
      Follicle, Cyst                                                2 (4%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                     8 (16%)      6 (13%)     11 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (44)         (45)                                                
      Abscess                                                       1 (2%)       1 (2%)                                             
      Cyst                                            22 (44%)     15 (34%)     14 (31%)                                            
      Inflammation, Chronic                                         5 (11%)      2 (4%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
   Uterus                                             (50)         (49)         (49)                                                
      Congestion                                       1 (2%)                                                                       
      Inflammation, Necrotizing                        1 (2%)       2 (4%)       3 (6%)                                             
      Endometrium, Hyperplasia, Cystic                35 (70%)     35 (71%)     28 (57%)                                            
      Endometrium, Metaplasia, Squamous                                          2 (4%)                                             
      Lumen, Dilatation                                1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (48)         (49)                                                
      Sternal, Hyperplasia                                                       1 (2%)                                             
      Sternal, Myelofibrosis                          21 (42%)     19 (40%)     18 (37%)                                            
   Lymph Node                                         (50)         (48)         (46)                                                
      Mediastinal, Hyperplasia, Lymphoid               1 (2%)                                                                       
      Mediastinal, Inflammation, Chronic                                         1 (2%)                                             
      Mesenteric, Abscess                                           1 (2%)                                                          
      Mesenteric, Hyperplasia, Lymphoid                                          1 (2%)                                             
   Lymph Node, Bronchial                              (26)         (38)         (36)                                                
      Amyloid Deposition                                                         1 (3%)                                             
      Hemorrhage, Acute                                             1 (3%)                                                          
      Hyperplasia, Lymphoid                            3 (12%)      1 (3%)       1 (3%)                                             
      Inflammation, Chronic                                                      1 (3%)                                             
   Lymph Node, Mandibular                             (45)         (41)         (40)                                                
      Hemorrhage, Acute                                1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            5 (11%)      5 (12%)      4 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (48)         (49)                                                
      Amyloid Deposition                                                         1 (2%)                                             
      Atrophy                                                       1 (2%)                                                          
      Congestion                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 4 (8%)       8 (17%)      3 (6%)                                             
      Hyperplasia, Lymphoid                            3 (6%)       6 (13%)      6 (12%)                                            
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                                     2 (4%)                                                          
      Capsule, Inflammation, Chronic                                1 (2%)                                                          
      Capsule, Inflammation, Suppurative               1 (2%)                                                                       
   Thymus                                             (42)         (37)         (35)                                                
      Amyloid Deposition                                                         1 (3%)                                             
      Inflammation, Chronic, Diffuse                                             1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (37)         (39)                                                
      Inflammation, Chronic                                         1 (3%)                                                          
      Duct, Dilatation                                 1 (3%)                                                                       
   Skin                                               (50)         (50)         (48)                                                
      Ulcer                                            1 (2%)                    1 (2%)                                             
      Hair Follicle, Atrophy                           5 (10%)      8 (16%)      7 (15%)                                            
      Subcutaneous Tissue, Inflammation, Subacute      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (48)         (50)                                                
      Cranium, Developmental Malformation              1 (2%)                                                                       
   Skeletal Muscle                                                 (1)          (1)                                                 
      Inflammation, Focal, Suppurative                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Hemorrhage, Acute, Multifocal                                              1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Hypothalamus, Atrophy                            4 (8%)       1 (2%)       2 (4%)                                             
      Thalamus, Atrophy                                             1 (2%)                                                          
      Thalamus, Mineralization                         5 (10%)     12 (24%)     10 (20%)                                            
      Ventricle, Dilatation                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (47)         (49)                                                
      Epithelium, Erosion                              1 (2%)                                                                       
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Lung                                               (50)         (47)         (49)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
      Inflammation, Chronic                                         2 (4%)                                                          
      Inflammation, Chronic, Multifocal               26 (52%)     19 (40%)     18 (37%)                                            
      Inflammation, Multifocal, Suppurative                         1 (2%)                                                          
      Leukocytosis                                     1 (2%)                    2 (4%)                                             
      Alveolar Epithelium, Hyperplasia                              2 (4%)       4 (8%)                                             
      Alveolus, Amyloid Deposition, Multifocal                                   1 (2%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       2 (4%)                                                          
   Nose                                               (50)         (48)         (49)                                                
      Mucosa, Inflammation, Suppurative                2 (4%)       1 (2%)       3 (6%)                                             
      Olfactory Epithelium, Cytoplasmic Alteration                               1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                                        2 (4%)                                             
      Respiratory Epithelium, Metaplasia, Squamous                               4 (8%)                                             
   Trachea                                            (49)         (46)         (49)                                                
      Glands, Cyst                                                               1 (2%)                                             
      Peritracheal Tissue, Inflammation,                                                                                            
          Suppurative                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (47)                      (42)                                                
      Sclera, Inflammation, Chronic, Focal                                       1 (2%)                                             
   Harderian Gland                                    (1)          (1)          (1)                                                 
      Hyperplasia                                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (48)                                                
      Amyloid Deposition                                            1 (2%)       2 (4%)                                             
      Cyst, Multiple                                                1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (4%)                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (4%)                    1 (2%)                                             
      Inflammation, Chronic                            4 (8%)      11 (22%)      2 (4%)                                             
      Nephropathy                                      1 (2%)       3 (6%)       5 (10%)                                            
      Renal Tubule, Crystals                                                     1 (2%)                                             
      Renal Tubule, Cytomegaly                                                   1 (2%)                                             
      Renal Tubule, Dilatation                                      2 (4%)       1 (2%)                                             
   Urinary Bladder                                    (50)         (47)         (48)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                            7 (14%)     13 (28%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            9           11                                                  
    Moribund                                          11            5            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           36           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (48)         (44)         (44)                                                
      Hyperplasia, Lymphoid                            2 (4%)                    3 (7%)                                             
   Liver                                              (50)         (48)         (49)                                                
      Cytomegaly                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal                               1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Inflammation, Chronic, Multifocal                             1 (2%)       3 (6%)                                             
      Necrosis                                         1 (2%)       2 (4%)                                                          
      Sinusoid, Ectasia                                             1 (2%)                                                          
   Pancreas                                           (50)         (45)         (47)                                                
      Atrophy                                                       1 (2%)                                                          
   Pharynx                                            (1)                                                                           
      Epithelium, Hyperplasia, Focal                   1 (100%)                                                                     
   Salivary Glands                                    (50)         (48)         (49)                                                
      Hyperplasia, Lymphoid                            4 (8%)                    6 (12%)                                            
      Infiltration Cellular, Lymphocyte                             1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Multifocal                3 (6%)       1 (2%)       2 (4%)                                             
   Stomach, Forestomach                               (49)         (46)         (45)                                                
      Congestion                                                    1 (2%)                                                          
      Cyst                                             1 (2%)       1 (2%)                                                          
      Erosion                                          1 (2%)                                                                       
      Hyperkeratosis                                   3 (6%)       1 (2%)       2 (4%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Squamous                                         1 (2%)       2 (4%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Ulcer, Multiple                                  1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (44)         (47)                                                
      Dysplasia                                        1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Ulcer, Multiple                                  2 (4%)                                                                       
   Tooth                                              (5)          (1)          (3)                                                 
      Abscess                                          3 (60%)      1 (100%)     2 (67%)                                            
      Developmental Malformation                       1 (20%)                   1 (33%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Dysplasia                                        1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (49)                                                
      Cardiomyopathy, Focal                                                      1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Atrium, Thrombosis                               1 (2%)       1 (2%)                                                          
      Myocardium, Necrosis                                                       1 (2%)                                             
      Valve, Degeneration, Mucoid                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (45)         (47)                                                
      Subcapsular, Hyperplasia                        17 (34%)      5 (11%)      6 (13%)                                            
   Adrenal Gland, Cortex                              (50)         (45)         (47)                                                
      Hyperplasia, Focal                               5 (10%)                                                                      
      Hypertrophy                                                   1 (2%)                                                          
   Adrenal Gland, Medulla                             (48)         (44)         (41)                                                
      Degeneration, Focal                                                        1 (2%)                                             
   Pituitary Gland                                    (44)         (37)         (46)                                                
      Pars Distalis, Hyperplasia                       1 (2%)       1 (3%)       2 (4%)                                             
   Thyroid Gland                                      (50)         (45)         (48)                                                
      Cyst                                                          1 (2%)                                                          
      Follicular Cell, Hyperplasia, Focal              5 (10%)                   5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                              (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
   Preputial Gland                                    (10)         (5)          (8)                                                 
      Abscess                                          3 (30%)                   3 (38%)                                            
      Cyst                                             3 (30%)      3 (60%)      2 (25%)                                            
      Inflammation                                     3 (30%)      1 (20%)      2 (25%)                                            
      Inflammation, Suppurative                                     1 (20%)                                                         
   Prostate                                           (50)         (44)         (43)                                                
      Abscess                                          2 (4%)                    2 (5%)                                             
   Seminal Vesicle                                    (49)         (15)         (44)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Dilatation                                       2 (4%)                    2 (5%)                                             
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
   Testes                                             (50)         (44)         (47)                                                
      Atrophy                                          4 (8%)       8 (18%)      4 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (48)         (46)         (47)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Iliac, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Iliac, Inflammation, Chronic                     1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         2 (4%)                                             
      Mesenteric, Autolysis                            1 (2%)                                                                       
      Mesenteric, Hematopoietic Cell Proliferation                  1 (2%)                                                          
      Mesenteric, Hyperplasia, Lymphoid                2 (4%)                    3 (6%)                                             
      Mesenteric, Hyperplasia, Re Cell                              1 (2%)                                                          
      Mesenteric, Inflammation, Chronic                2 (4%)                                                                       
      Mesenteric, Inflammation, Suppurative            1 (2%)                                                                       
   Lymph Node, Bronchial                              (35)         (38)         (36)                                                
      Hyperplasia, Lymphoid                            1 (3%)       2 (5%)       4 (11%)                                            
   Lymph Node, Mandibular                             (41)         (29)         (38)                                                
      Hyperplasia, Lymphoid                            6 (15%)      2 (7%)       4 (11%)                                            
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (3%)                                             
      Inflammation, Chronic                                         1 (3%)                                                          
   Spleen                                             (50)         (47)         (49)                                                
      Ectopic Tissue                                                2 (4%)                                                          
      Hematopoietic Cell Proliferation                10 (20%)      5 (11%)      5 (10%)                                            
      Hyperplasia, Lymphoid                            3 (6%)       4 (9%)       3 (6%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (5)          (19)         (15)                                                
      Duct, Cyst                                                                 1 (7%)                                             
   Skin                                               (50)         (47)         (47)                                                
      Abscess                                                       1 (2%)                                                          
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Hair Follicle, Atrophy                           1 (2%)       4 (9%)       2 (4%)                                             
      Prepuce, Inflammation, Suppurative                                         1 (2%)                                             
      Prepuce, Ulcer                                   8 (16%)      1 (2%)                                                          
      Subcutaneous Tissue, Hyperplasia, Lymphoid                                 1 (2%)                                             
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Coccygeal, Inflammation, Multifocal,                                                                                          
          Suppurative                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (48)                                                
      Thalamus, Mineralization                        19 (38%)     21 (43%)      9 (19%)                                            
      Ventricle, Dilatation                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (47)         (47)                                                
      Epithelium, Hyperplasia, Focal                                1 (2%)                                                          
   Lung                                               (50)         (49)         (49)                                                
      Congestion, Acute                                1 (2%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)       4 (8%)                                             
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Chronic, Multifocal               21 (42%)     19 (39%)     16 (33%)                                            
      Inflammation, Suppurative                                                  1 (2%)                                             
      Leukocytosis                                     1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (6%)       4 (8%)       1 (2%)                                             
      Alveolus, Pigmentation, Diffuse                                            1 (2%)                                             
      Bronchiole, Hyperplasia                          1 (2%)                    1 (2%)                                             
      Venule, Thrombosis                                                         1 (2%)                                             
   Nose                                               (50)         (48)         (48)                                                
      Foreign Body                                     1 (2%)                                                                       
      Glands, Hyperplasia, Focal                                                 1 (2%)                                             
      Glands, Inflammation, Focal, Suppurative         2 (4%)                                                                       
      Mucosa, Inflammation, Suppurative                2 (4%)                    2 (4%)                                             
      Olfactory Epithelium, Atrophy                                              1 (2%)                                             
      Respiratory Epithelium, Metaplasia, Squamous                               2 (4%)                                             
   Trachea                                            (50)         (46)         (47)                                                
      Glands, Cyst                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (45)                      (45)                                                
      Inflammation, Necrotizing                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05097-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:38  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)                                                
      Cyst                                             1 (2%)       3 (6%)                                                          
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte               41 (82%)     38 (78%)     42 (86%)                                            
      Inflammation, Chronic, Multifocal                                          1 (2%)                                             
      Inflammation, Suppurative                        2 (4%)       1 (2%)       2 (4%)                                             
      Nephropathy                                      6 (12%)      5 (10%)     10 (20%)                                            
      Pelvis, Dilatation                               1 (2%)                                                                       
      Pelvis, Inflammation, Suppurative                4 (8%)                    1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                 1 (2%)                                                                       
      Renal Tubule, Inflammation, Suppurative          2 (4%)                                                                       
   Urinary Bladder                                    (49)         (44)         (47)                                                
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Dilatation                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic                            5 (10%)                   1 (2%)                                             
      Inflammation, Suppurative                        3 (6%)       1 (2%)                                                          
      Lumen, Hemorrhage                                                          1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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