TDMS Study 05097-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ALPHA-CHLOROACETOPHENONE
NTP Experiment-Test: 05097-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
Facility: Battelle Northwest
Chemical CAS #: 532-27-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 8 13 10
Dead 2 9 8
Survivors
Terminal Sacrifice 40 27 32
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (49) (48)
Epithelium, Hyperplasia, Focal 1 (2%)
Gallbladder (45) (33) (39)
Inflammation, Suppurative 2 (6%)
Intestine Large, Cecum (49) (41) (42)
Hyperplasia, Lymphoid 1 (2%)
Ulcer, Multifocal 1 (2%)
Intestine Small, Duodenum (48) (43) (41)
Ulcer 1 (2%)
Intestine Small, Ileum (50) (45) (43)
Amyloid Deposition 3 (6%) 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (50) (49) (49)
Cyst 1 (2%)
Cytomegaly 1 (2%)
Inflammation, Chronic, Multifocal 2 (4%) 3 (6%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (2%) 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Vein, Thrombosis 1 (2%)
Mesentery (16) (13) (19)
Hyperplasia, Lymphoid 1 (6%) 2 (11%)
Inflammation, Chronic 2 (13%) 1 (8%) 2 (11%)
Inflammation, Suppurative 2 (15%)
Fat, Necrosis 1 (8%)
Vein, Thrombosis 1 (8%)
Pancreas (50) (48) (48)
Amyloid Deposition, Focal 1 (2%)
Atrophy 2 (4%) 2 (4%) 2 (4%)
Cyst 1 (2%) 1 (2%)
Degeneration, Focal 1 (2%)
Fibrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis, Coagulative 1 (2%)
Salivary Glands (50) (50) (48)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic, Multifocal 2 (4%)
Duct, Hyperplasia 1 (2%)
Stomach, Forestomach (49) (48) (48)
Developmental Malformation 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 2 (4%) 6 (13%)
Inflammation, Chronic 1 (2%)
Stomach, Glandular (50) (47) (48)
Atrophy 1 (2%)
Cyst 1 (2%)
Tooth (2)
Dysplasia 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (49) (49)
Aorta, Inflammation, Chronic 1 (2%)
Heart (50) (50) (49)
Amyloid Deposition, Multifocal 1 (2%)
Atrium, Inflammation, Suppurative 1 (2%)
Atrium, Thrombosis 2 (4%)
Myocardium, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (46) (48)
Subcapsular, Hyperplasia 49 (98%) 42 (91%) 46 (96%)
Adrenal Gland, Cortex (46) (44) (46)
Amyloid Deposition 1 (2%)
Cyst 2 (4%)
Degeneration 41 (89%) 39 (89%) 37 (80%)
Fibrosis 37 (80%) 23 (52%) 36 (78%)
Focal Cellular Change 1 (2%)
Adrenal Gland, Medulla (44) (38) (39)
Amyloid Deposition 1 (3%)
Degeneration 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (45) (43) (45)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 11 (24%) 10 (23%) 13 (29%)
Thyroid Gland (49) (46) (49)
Inflammation, Chronic 1 (2%)
C-Cell, Hyperplasia 3 (6%) 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%)
Follicular Cell, Hyperplasia 8 (16%) 6 (13%) 11 (22%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (44) (45)
Abscess 1 (2%) 1 (2%)
Cyst 22 (44%) 15 (34%) 14 (31%)
Inflammation, Chronic 5 (11%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Uterus (50) (49) (49)
Congestion 1 (2%)
Inflammation, Necrotizing 1 (2%) 2 (4%) 3 (6%)
Endometrium, Hyperplasia, Cystic 35 (70%) 35 (71%) 28 (57%)
Endometrium, Metaplasia, Squamous 2 (4%)
Lumen, Dilatation 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48) (49)
Sternal, Hyperplasia 1 (2%)
Sternal, Myelofibrosis 21 (42%) 19 (40%) 18 (37%)
Lymph Node (50) (48) (46)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Inflammation, Chronic 1 (2%)
Mesenteric, Abscess 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Bronchial (26) (38) (36)
Amyloid Deposition 1 (3%)
Hemorrhage, Acute 1 (3%)
Hyperplasia, Lymphoid 3 (12%) 1 (3%) 1 (3%)
Inflammation, Chronic 1 (3%)
Lymph Node, Mandibular (45) (41) (40)
Hemorrhage, Acute 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 5 (11%) 5 (12%) 4 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (50) (48) (49)
Amyloid Deposition 1 (2%)
Atrophy 1 (2%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 8 (17%) 3 (6%)
Hyperplasia, Lymphoid 3 (6%) 6 (13%) 6 (12%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 2 (4%)
Capsule, Inflammation, Chronic 1 (2%)
Capsule, Inflammation, Suppurative 1 (2%)
Thymus (42) (37) (35)
Amyloid Deposition 1 (3%)
Inflammation, Chronic, Diffuse 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (37) (39)
Inflammation, Chronic 1 (3%)
Duct, Dilatation 1 (3%)
Skin (50) (50) (48)
Ulcer 1 (2%) 1 (2%)
Hair Follicle, Atrophy 5 (10%) 8 (16%) 7 (15%)
Subcutaneous Tissue, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (48) (50)
Cranium, Developmental Malformation 1 (2%)
Skeletal Muscle (1) (1)
Inflammation, Focal, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Hemorrhage, Acute, Multifocal 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Hypothalamus, Atrophy 4 (8%) 1 (2%) 2 (4%)
Thalamus, Atrophy 1 (2%)
Thalamus, Mineralization 5 (10%) 12 (24%) 10 (20%)
Ventricle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (47) (49)
Epithelium, Erosion 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Lung (50) (47) (49)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Inflammation, Chronic 2 (4%)
Inflammation, Chronic, Multifocal 26 (52%) 19 (40%) 18 (37%)
Inflammation, Multifocal, Suppurative 1 (2%)
Leukocytosis 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 4 (8%)
Alveolus, Amyloid Deposition, Multifocal 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%)
Nose (50) (48) (49)
Mucosa, Inflammation, Suppurative 2 (4%) 1 (2%) 3 (6%)
Olfactory Epithelium, Cytoplasmic Alteration 1 (2%)
Respiratory Epithelium, Hyperplasia 2 (4%)
Respiratory Epithelium, Metaplasia, Squamous 4 (8%)
Trachea (49) (46) (49)
Glands, Cyst 1 (2%)
Peritracheal Tissue, Inflammation,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (47) (42)
Sclera, Inflammation, Chronic, Focal 1 (2%)
Harderian Gland (1) (1) (1)
Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (48)
Amyloid Deposition 1 (2%) 2 (4%)
Cyst, Multiple 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (2%)
Inflammation, Chronic 4 (8%) 11 (22%) 2 (4%)
Nephropathy 1 (2%) 3 (6%) 5 (10%)
Renal Tubule, Crystals 1 (2%)
Renal Tubule, Cytomegaly 1 (2%)
Renal Tubule, Dilatation 2 (4%) 1 (2%)
Urinary Bladder (50) (47) (48)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic 7 (14%) 13 (28%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 5 9 11
Moribund 11 5 6
Survivors
Terminal Sacrifice 34 36 33
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (48) (44) (44)
Hyperplasia, Lymphoid 2 (4%) 3 (7%)
Liver (50) (48) (49)
Cytomegaly 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%) 3 (6%)
Necrosis 1 (2%) 2 (4%)
Sinusoid, Ectasia 1 (2%)
Pancreas (50) (45) (47)
Atrophy 1 (2%)
Pharynx (1)
Epithelium, Hyperplasia, Focal 1 (100%)
Salivary Glands (50) (48) (49)
Hyperplasia, Lymphoid 4 (8%) 6 (12%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Chronic, Multifocal 3 (6%) 1 (2%) 2 (4%)
Stomach, Forestomach (49) (46) (45)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Erosion 1 (2%)
Hyperkeratosis 3 (6%) 1 (2%) 2 (4%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Squamous 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Ulcer, Multiple 1 (2%)
Stomach, Glandular (50) (44) (47)
Dysplasia 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Ulcer, Multiple 2 (4%)
Tooth (5) (1) (3)
Abscess 3 (60%) 1 (100%) 2 (67%)
Developmental Malformation 1 (20%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Dysplasia 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (49)
Cardiomyopathy, Focal 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (2%)
Myocardium, Necrosis 1 (2%)
Valve, Degeneration, Mucoid 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (45) (47)
Subcapsular, Hyperplasia 17 (34%) 5 (11%) 6 (13%)
Adrenal Gland, Cortex (50) (45) (47)
Hyperplasia, Focal 5 (10%)
Hypertrophy 1 (2%)
Adrenal Gland, Medulla (48) (44) (41)
Degeneration, Focal 1 (2%)
Pituitary Gland (44) (37) (46)
Pars Distalis, Hyperplasia 1 (2%) 1 (3%) 2 (4%)
Thyroid Gland (50) (45) (48)
Cyst 1 (2%)
Follicular Cell, Hyperplasia, Focal 5 (10%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (1)
Inflammation, Suppurative 1 (100%)
Preputial Gland (10) (5) (8)
Abscess 3 (30%) 3 (38%)
Cyst 3 (30%) 3 (60%) 2 (25%)
Inflammation 3 (30%) 1 (20%) 2 (25%)
Inflammation, Suppurative 1 (20%)
Prostate (50) (44) (43)
Abscess 2 (4%) 2 (5%)
Seminal Vesicle (49) (15) (44)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Dilatation 2 (4%) 2 (5%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Testes (50) (44) (47)
Atrophy 4 (8%) 8 (18%) 4 (9%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (48) (46) (47)
Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Inflammation, Chronic 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 2 (4%)
Mesenteric, Autolysis 1 (2%)
Mesenteric, Hematopoietic Cell Proliferation 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 2 (4%) 3 (6%)
Mesenteric, Hyperplasia, Re Cell 1 (2%)
Mesenteric, Inflammation, Chronic 2 (4%)
Mesenteric, Inflammation, Suppurative 1 (2%)
Lymph Node, Bronchial (35) (38) (36)
Hyperplasia, Lymphoid 1 (3%) 2 (5%) 4 (11%)
Lymph Node, Mandibular (41) (29) (38)
Hyperplasia, Lymphoid 6 (15%) 2 (7%) 4 (11%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (3%)
Inflammation, Chronic 1 (3%)
Spleen (50) (47) (49)
Ectopic Tissue 2 (4%)
Hematopoietic Cell Proliferation 10 (20%) 5 (11%) 5 (10%)
Hyperplasia, Lymphoid 3 (6%) 4 (9%) 3 (6%)
Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (5) (19) (15)
Duct, Cyst 1 (7%)
Skin (50) (47) (47)
Abscess 1 (2%)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Hair Follicle, Atrophy 1 (2%) 4 (9%) 2 (4%)
Prepuce, Inflammation, Suppurative 1 (2%)
Prepuce, Ulcer 8 (16%) 1 (2%)
Subcutaneous Tissue, Hyperplasia, Lymphoid 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Coccygeal, Inflammation, Multifocal,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (48)
Thalamus, Mineralization 19 (38%) 21 (43%) 9 (19%)
Ventricle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (47) (47)
Epithelium, Hyperplasia, Focal 1 (2%)
Lung (50) (49) (49)
Congestion, Acute 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 4 (8%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic, Multifocal 21 (42%) 19 (39%) 16 (33%)
Inflammation, Suppurative 1 (2%)
Leukocytosis 1 (2%) 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 4 (8%) 1 (2%)
Alveolus, Pigmentation, Diffuse 1 (2%)
Bronchiole, Hyperplasia 1 (2%) 1 (2%)
Venule, Thrombosis 1 (2%)
Nose (50) (48) (48)
Foreign Body 1 (2%)
Glands, Hyperplasia, Focal 1 (2%)
Glands, Inflammation, Focal, Suppurative 2 (4%)
Mucosa, Inflammation, Suppurative 2 (4%) 2 (4%)
Olfactory Epithelium, Atrophy 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%)
Trachea (50) (46) (47)
Glands, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (45) (45)
Inflammation, Necrotizing 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49)
Cyst 1 (2%) 3 (6%)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 41 (82%) 38 (78%) 42 (86%)
Inflammation, Chronic, Multifocal 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%) 2 (4%)
Nephropathy 6 (12%) 5 (10%) 10 (20%)
Pelvis, Dilatation 1 (2%)
Pelvis, Inflammation, Suppurative 4 (8%) 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Inflammation, Suppurative 2 (4%)
Urinary Bladder (49) (44) (47)
Calculus Micro Observation Only 1 (2%)
Dilatation 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 5 (10%) 1 (2%)
Inflammation, Suppurative 3 (6%) 1 (2%)
Lumen, Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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