TDMS Study 05097-02 Pathology Tables
NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 Facility: Battelle Northwest Chemical CAS #: 532-27-4 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3| | 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Peyer's Patch, Lymphoma Malignant | | Lymphocytic | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Lymphocytic | X X X X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Squamous Cell Carcinoma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3| | 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + I + + + + + + + I + + + + + + + + + I + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + I + + + + + + + I + + + + + M + + + I + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Islets, Pancreatic | + I + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + M M + + M + + M M + + M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + M I + M + + +| Pars Distalis, Adenoma | X X X X X X X| Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor NOS | | Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Sarcoma | X | Endometrium, Polyp | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Sternal, Lymphoma Malignant | | Histiocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Lymphoma Malignant Histiocytic| | Mediastinal, Lymphoma Malignant | | Histiocytic | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| X | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3| | 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mesenteric, Histiocytic Sarcoma | X | Mesenteric, Lymphoma Malignant | | Histiocytic | | Mesenteric, Lymphoma Malignant | | Lymphocytic | X | Renal, Lymphoma Malignant Histiocytic| X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + M + + + M M M + + M M M M + + M + M + M| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X X X | Lymphoma Malignant Lymphocytic | X X X X X X | Lymphoma Malignant Mixed | X | Squamous Cell Carcinoma, Metastatic, | | Ear | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Lymphocytic | X X X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + M M + + + + + M + + + + M + M + + +| Adenocarcinoma | X | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3| | 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Histiocytic | X X | Lymphoma Malignant Lymphocytic | X X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Squamous Cell Carcinoma | | __________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X X X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Histiocytic | X X X | Lymphoma Malignant Lymphocytic | X X X X X X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | M + + A + + + + + + A + + + + + + + + + + + + M +| 45 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Peyer's Patch, Lymphoma Malignant | | | Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X | 6 | Hepatocellular Carcinoma, Multiple | X X | 2 | Hepatocellular Adenoma | X X X | 4 | Lymphoma Malignant Histiocytic | X X X | 4 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 16 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X X X X | 7 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X X | 4 | Lymphoma Malignant Lymphocytic | X X | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X | 3 | Lymphoma Malignant Lymphocytic | X X X X | 10 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Lymphoma Malignant | | | Lymphocytic | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + I +| 46 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + I +| 44 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M + + M M + + M M + M M M M M M + + + M + M| 25 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + I + + +| 45 | Pars Distalis, Adenoma | X X X X X X X X X X X X X| 20 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor NOS | X | 1 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Sarcoma | | 1 | Endometrium, Polyp | X X X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sternal, Lymphoma Malignant | | | Histiocytic | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Iliac, Lymphoma Malignant Histiocytic| X | 1 | Mediastinal, Lymphoma Malignant | | | Histiocytic | X X | 3 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | X X | 3 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Mesenteric, Histiocytic Sarcoma | | 1 | Mesenteric, Lymphoma Malignant | | | Histiocytic | X | 1 | Mesenteric, Lymphoma Malignant | | | Lymphocytic | | 1 | Renal, Lymphoma Malignant Histiocytic| X X | 3 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M M M M M M M + I + + M I + M + M + + + + + + +| 26 | Lymphoma Malignant Histiocytic | X X X | 4 | Lymphoma Malignant Lymphocytic | X X X | 6 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M M + + + M + + + M + + + +| 45 | Lymphoma Malignant Histiocytic | X X X | 6 | Lymphoma Malignant Lymphocytic | X X X X X | 11 | Lymphoma Malignant Mixed | X | 2 | Squamous Cell Carcinoma, Metastatic, | | | Ear | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X X X | 5 | Lymphoma Malignant Lymphocytic | X X X X X X X | 13 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Thymus | M + + + M + + + M + M M + + + + + + + M + + + + M| 42 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + M + + + + + + + M + M + M + + + + + + + +| 39 | Adenocarcinoma | X X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X X | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X | 4 | Alveolar/Bronchiolar Carcinoma | X X | 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 2 | Lymphoma Malignant Histiocytic | X X | 4 | Lymphoma Malignant Lymphocytic | X X X X X X | 11 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Eye | A + + A + + + + + + + + + + + + + A + + + + + + +| 47 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X X | 3 | Lymphoma Malignant Lymphocytic | X X X X X X | 12 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X X | 2 | Lymphoma Malignant Lymphocytic | X X X | 7 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| | | 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Histiocytic | X X X X | 7 | Lymphoma Malignant Lymphocytic | X X X X X X X | 13 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2| | 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Gallbladder | + + M I + I + + + + + + + + + M A + + M A + M M A| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + A + + + + + + A + A| __________________________________________________________________________| Intestine Large, Cecum | + + + M + + + + + A + + + + A + + + A + + A + A| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + A + A| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + A + A| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + A + + + A + + A + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + A + + + A + + A + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + A + + A + A| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + A + + A + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + A + +| Hepatoblastoma | | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | X X X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + + + + + | Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + A + + + + + + A + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + A + + + + + + A + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + A + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + A + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2| | 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + A + + + + + A + + + A + + + + +| Bilateral, Lymphoma Malignant | | Lymphocytic | | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + I + + + + A + + + + + A + + + A + + A + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + I + + + A + + + + + A + + + A I + A + +| Lymphoma Malignant Mixed | | Pheochromocytoma NOS | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + I + A + + + + + + A + +| __________________________________________________________________________| Parathyroid Gland | M + + M M + M M M M M M M M + M M + M + M M + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + M + +| Pars Distalis, Adenoma | X X X X X X X X X X X X| Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + A + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + I M + + + + + + I M + + + + + + + A + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + A + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Polyp | | Endometrium, Polyp | X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + M + + + + + + + + + + + + + A + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Lymphoma Malignant Lymphocytic| X X | Iliac, Lymphoma Malignant Mixed | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mesenteric, Hepatocellular Carcinoma,| | Metastatic, Liver | X | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2| | 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mesenteric, Lymphoma Malignant | | Lymphocytic | X X | Mesenteric, Lymphoma Malignant Mixed | X | Pancreatic, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Lymphocytic| X X X X X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Bronchial | + M + + + M + + + + + + + + + + + + + M + I| Lymphoma Malignant Lymphocytic | X X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + M + + M +| Lymphoma Malignant Lymphocytic | X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + A + + + + + + A + +| Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | X X X X X X | Lymphoma Malignant Mixed | X X X X | Sarcoma | X | __________________________________________________________________________| Thymus | + + + + + + + + + M + I + + + + M + + I M + A + M| Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + M + M M + + + M + + + + + +| Adenoacanthoma | X | Adenocarcinoma | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + M + + + + + + + + + + + + + A + +| Rib, Osteosarcoma | X | __________________________________________________________________________| Skeletal Muscle | | Head, Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + A + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7| DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2| | 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + A + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + A + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Liver | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X X X X X | Lymphoma Malignant Mixed | X X X X | Osteosarcoma, Multiple, Metastatic, | | Bone | X | __________________________________________________________________________| Nose | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + M + + + + + + + + + + A + +| Lymphoma Malignant Mixed | | Peritracheal Tissue, Lymphoma | | Malignant Mixed | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | Osteosarcoma, Multiple, Metastatic, | | Bone | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +| Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X X X X X X | Lymphoma Malignant Mixed | X X X X | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| | DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| | | 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + A + + M + + M + + + + + A A + + + A + + +| 33 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + M + + + + + + + + + + + + +| 41 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 45 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + M + + A + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X X X X | 5 | Hepatocellular Adenoma | X X X X X | 5 | Hepatocellular Adenoma, Multiple | | 3 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Mesentery | + + + + + + +| 13 | Lymphoma Malignant Lymphocytic | X X | 5 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Lymphocytic | X X | 4 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X X | 5 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X | 2 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Lymphocytic | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| | DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| | | 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 | Bilateral, Lymphoma Malignant | | | Lymphocytic | X | 1 | Subcapsular, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| 44 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + I + + + M + + + + + + + + + + + + + M + + +| 38 | Lymphoma Malignant Mixed | X | 1 | Pheochromocytoma NOS | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + I + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M M M M + M M + + M M M M M + M + + M M| 14 | __________________________________________________________________________|____________| Pituitary Gland | + + + I + + + I + + + M + + + + + + + + M M + + +| 43 | Pars Distalis, Adenoma | X X X | 15 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + M +| 46 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + M +| 44 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 2 | Polyp | X | 1 | Endometrium, Polyp | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| | DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| | | 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + M + + + + + M +| 48 | Iliac, Lymphoma Malignant Lymphocytic| | 2 | Iliac, Lymphoma Malignant Mixed | | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | X | 2 | Mesenteric, Hepatocellular Carcinoma,| | | Metastatic, Liver | | 1 | Mesenteric, Lymphoma Malignant | | | Lymphocytic | | 2 | Mesenteric, Lymphoma Malignant Mixed | | 1 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant Lymphocytic| | 5 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M + + + + + + + + + + + M I + + + I + M +| 38 | Lymphoma Malignant Lymphocytic | X X X X X | 9 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + M + + + + + M + + + + + M M| 41 | Lymphoma Malignant Lymphocytic | X X X | 7 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | Lymphoma Malignant Lymphocytic | X X X X X X | 12 | Lymphoma Malignant Mixed | X | 5 | Sarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + M + + M + M A + + + + + + + + M M + + + + + + +| 37 | Lymphoma Malignant Lymphocytic | X X X X | 7 | Lymphoma Malignant Mixed | X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + + + M I + + M M + + + + + M + + + M + + M| 37 | Adenoacanthoma | | 1 | Adenocarcinoma | | 1 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Lymphoma Malignant Lymphocytic | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| | DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| | | 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | X | 2 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Rib, Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Head, Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + I + + A + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lung | + + + + + + + A + + + + + + + + + + + + + I + + +| 47 | Alveolar/Bronchiolar Adenoma | | 1 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Liver | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Lymphoma Malignant Lymphocytic | X X X X X | 10 | Lymphoma Malignant Mixed | X | 5 | Osteosarcoma, Multiple, Metastatic, | | | Bone | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + A + + + + + + + + + + + + + + + I +| 46 | Lymphoma Malignant Mixed | X | 1 | Peritracheal Tissue, Lymphoma | | | Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | M | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| | DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| | | 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X X X X X | 6 | Lymphoma Malignant Mixed | X | 3 | Osteosarcoma, Multiple, Metastatic, | | | Bone | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Lymphocytic | X X X | 6 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X X X X X X X | 14 | Lymphoma Malignant Mixed | X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3| | 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + A M + + + + A + + + + M + + A + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + M + + M + + + + + M + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + A + + + + + A + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + + + + A + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + M + + + + + + + A + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + + + + + + + + + + +| Carcinoma, Metastatic, Uterus | X | Histiocytic Sarcoma | X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3| | 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Histiocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | I + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Adrenal Gland, Medulla | I + + + + + + + + + + + + + + I + + + I + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + M + + + + + + + + I + + + + I + +| Adenoma | X | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Parathyroid Gland | + M M + + + M + + + M M + M + M M + M M M M M M M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + M + I + + + + +| Pars Distalis, Adenoma | X X X X X X X X| Pars Distalis, Carcinoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + I + + + + + A + + + + + I + + + + + + + + + +| Granulosa Cell Tumor NOS | | Hemangiosarcoma | | Histiocytic Sarcoma | X X | Lymphoma Malignant Histiocytic | | Mixed Tumor Benign | X | Bilateral, Carcinoma, Metastatic, | | Uterus | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Hemangiosarcoma | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3| | 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Leiomyoma | X| Endometrium, Polyp | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + M + + + + + M M + + + + + + + + + + + +| Iliac, Lymphoma Malignant Histiocytic| | Iliac, Lymphoma Malignant Lymphocytic| | Inguinal, Histiocytic Sarcoma | X | Mediastinal, Histiocytic Sarcoma | X X | Mediastinal, Lymphoma Malignant | | Histiocytic | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mesenteric, Histiocytic Sarcoma | X X | Mesenteric, Lymphoma Malignant | | Histiocytic | X | Mesenteric, Lymphoma Malignant | | Lymphocytic | X | Renal, Histiocytic Sarcoma | X | Renal, Lymphoma Malignant Histiocytic| X | Renal, Lymphoma Malignant Lymphocytic| X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + M M + + + + + M M + + + + M + + + + M + +| Histiocytic Sarcoma | X X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + M + + + M + M M + + M M + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3| | 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + M + + + M + M M + + + + + M + + + + + M + M + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + M + + + + + + + M + + M + + + M + + M + +| Adenocarcinoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Multiple, Metastatic,| | Harderian Gland | X | Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Uterus | X | Histiocytic Sarcoma | X X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | Vein, Mediastinum, Hemangiosarcoma, | | Metastatic, Uterus | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3| | 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + + + + + A + + + + + A + + + + + + + A + +| __________________________________________________________________________| Harderian Gland | + | Adenocarcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| | | 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + A + + + + + + A + M + + A + + + + + A| 39 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + M + + + + + M + + + + + + + + + A| 42 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + M + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Small | + + + + + + A + + + + + + + + A + + A + + + + + A| 43 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + I + M A + M + + + A| 41 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + A + + A + + + + + A| 43 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + + A + + + + + A| 43 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hepatocellular Carcinoma | X | 4 | Hepatocellular Adenoma | X | 2 | Hepatocellular Adenoma, Multiple | | 1 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + + | 19 | Carcinoma, Metastatic, Uterus | | 1 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| | | 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + M + + + + + + + + + + + + + + + + + A| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + A| 48 | Squamous Cell Papilloma | X X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + A| 48 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Histiocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + A| 48 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + M + + + I + + + + + + + + + + + A| 46 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | I + + M + + + + M I I + I + + + + + + + + + + + A| 39 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 | Adenoma | | 1 | Lymphoma Malignant Histiocytic | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | M M M + + + + + M M M M M M M M M + + + M M M + M| 19 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + I + + + +| 45 | Pars Distalis, Adenoma | X X X X | 12 | Pars Distalis, Carcinoma | X | 1 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + M A| 45 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| | | 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Granulosa Cell Tumor NOS | X | 1 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant Histiocytic | X | 1 | Mixed Tumor Benign | | 1 | Bilateral, Carcinoma, Metastatic, | | | Uterus | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Carcinoma | | 1 | Hemangiosarcoma | X | 1 | Leiomyoma | | 1 | Endometrium, Polyp | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 | Iliac, Lymphoma Malignant Histiocytic| X X | 2 | Iliac, Lymphoma Malignant Lymphocytic| X | 1 | Inguinal, Histiocytic Sarcoma | | 1 | Mediastinal, Histiocytic Sarcoma | | 2 | Mediastinal, Lymphoma Malignant | | | Histiocytic | X X | 3 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | X X | 2 | Mesenteric, Histiocytic Sarcoma | | 2 | Mesenteric, Lymphoma Malignant | | | Histiocytic | X | 2 | Mesenteric, Lymphoma Malignant | | | Lymphocytic | | 1 | Renal, Histiocytic Sarcoma | | 1 | Renal, Lymphoma Malignant Histiocytic| X X | 3 | Renal, Lymphoma Malignant Lymphocytic| | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M + + + + + + M + M + + + + M + M + + A| 36 | Histiocytic Sarcoma | | 3 | Lymphoma Malignant Histiocytic | X X | 3 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| | | 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + M + + + + + + + + A| 40 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X | 5 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Histiocytic Sarcoma | | 3 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X X | 5 | Lymphoma Malignant Mixed | X | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + M M + M + M M + + M + A| 35 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M + + + + M + + + + M + + M + + + + + + + M| 39 | Adenocarcinoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + I + + + + + + + + + + + + + + A| 48 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | X | 1 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| | | 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Adenocarcinoma, Multiple, Metastatic,| | | Harderian Gland | | 1 | Alveolar/Bronchiolar Adenoma | X X X | 4 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Uterus | | 1 | Histiocytic Sarcoma | | 3 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X | 4 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | Vein, Mediastinum, Hemangiosarcoma, | | | Metastatic, Uterus | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + + + A + A + + + + A + A + + A + + + + + +| 42 | __________________________________________________________________________|____________| Harderian Gland | | 1 | Adenocarcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Histiocytic | X | 2 | Lymphoma Malignant Lymphocytic | X X | 3 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| | | 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | | 3 | Lymphoma Malignant Histiocytic | X X | 3 | Lymphoma Malignant Lymphocytic | X X | 6 | Lymphoma Malignant Mixed | X | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + + + + + M M M + M + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + M + + + + + + + + + + + + M + + + + + + + +| Adenoma | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + A + + + + + + + + + + + + A + + + + + + + +| Adenocarcinoma | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Tooth | + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + I + + + + + + + + I + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Lymphoma Malignant Mixed | | Pheochromocytoma NOS | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Parathyroid Gland | + + M M + M M M + M M + M + + + M + + + + + M + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + M + I + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | I + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Sarcoma | X | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + M + + + + + + + + + + +| Inguinal, Lymphoma Malignant | | Histiocytic | | Mesenteric, Lymphoma Malignant | | Histiocytic | | Mesenteric, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Bronchial | + + + M + + + + M + M + M M M + + M + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + M + + M + M + + M + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | M + M M M M + M + + M M M M + + M M + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M + M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Lymphoma | | Malignant Histiocytic | | Subcutaneous Tissue, Lymphoma | | Malignant Mixed | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + A + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Harderian Gland | + | Adenoma | X | Sarcoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cell Type | | Cortex, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| | | 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + M + M + + + M + + + + + + + + M| 41 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + M + + + +| 46 | Adenoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 46 | Adenocarcinoma | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X | 6 | Hepatocellular Carcinoma, Multiple | X X X X| 5 | Hepatocellular Adenoma | X X | 4 | Hepatocellular Adenoma, Multiple | X | 1 | Lymphoma Malignant Histiocytic | X X | 2 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | | 1 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Tooth | + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| | | 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Mixed | X | 1 | Pheochromocytoma NOS | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + M + M M + + M + M M + + M M + + + M M + M M M +| 26 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + I + I + A + + + + + M + + + + + + +| 44 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + M + + + + + + + + M + + + +| 47 | Lymphoma Malignant Mixed | X | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Penis | +| 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 10 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 | Inguinal, Lymphoma Malignant | | | Histiocytic | X | 1 | Mesenteric, Lymphoma Malignant | | | Histiocytic | X | 1 | Mesenteric, Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| | | 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + M + M M + + + + M + + M + + M M M +| 35 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + M M + M + +| 41 | Hemangiosarcoma, Metastatic, Spleen | X | 1 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Histiocytic | X X | 2 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Thymus | + + + + M + + + + M M + M + M M M + M + + M + + M| 28 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + M M M M M M M M M M + M M M M M M M M M M M| 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Lymphoma | | | Malignant Histiocytic | X | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X X | 7 | Alveolar/Bronchiolar Carcinoma | X X X X | 6 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X| 3 | Lymphoma Malignant Histiocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| | | 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + A + + + + + + + + + A + + + + + A + + + + + + +| 45 | __________________________________________________________________________|____________| Harderian Gland | + + + | 4 | Adenoma | X X | 3 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | Cortex, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X X | 2 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | 9| 6| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Gallbladder | + A + + + A M + + + + + + + + + + + + + + M + A +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Cecum | + M + + + A + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Liver | + + + + + A + + + + + + + + + + + + + + + + + A +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + M + + + + + + + + + + + + + + + + + M +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Mixed | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Tooth | +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + A +| Capsule, Lymphoma Malignant | | Lymphocytic | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + A +| Hepatocellular Carcinoma, Metastatic,| | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | 9| 6| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Liver | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + A +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + M + M M M + M M + + M + + M M M + M + + + + A M| __________________________________________________________________________| Pituitary Gland | + I + + + A + M + + M + + M + + + + + + + + + M +| Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + A +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + A + + + + + + + + M M + + + + + + + A M| __________________________________________________________________________| Preputial Gland | + + + M +| __________________________________________________________________________| Prostate | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Seminal Vesicle | + + + A + + + + + + + A | __________________________________________________________________________| Testes | + + + + + A + + + + + + + + + + + + + + + + + A +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Lymph Node | + + + + + A + + + + + + + + + + + + + + + + + A +| Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mesenteric, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Bronchial | + + + M A M + M + + + + M + + + + + M + + A +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + M M + A + + + M + + + + + M + + M + + M + A +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + A + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Sarcoma | X | __________________________________________________________________________| Thymus | + M + I + A M + + + + + M + + M + + M + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M + + + M + + + + + M M M M + M M M M + M + M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Mixed | | Tail, Schwannoma NOS | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7| DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | 9| 6| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + A +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + + | Adenoma | X X X X | __________________________________________________________________________| Lacrimal Gland | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Cortex, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| | | 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | I + + + + + + + + A I + + M M + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + A + A M M + A + + + + + M M A A + +| 36 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + A A + + A + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Cecum | M + + + + + M + + A A + + A + + + + + + + A + + +| 40 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A A + + A + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + A A + + M + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A A + + M + + + + + + + A + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 | Lymphoma Malignant Lymphocytic | X| 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + A A + + M + + + + + + + A + + +| 43 | Lymphoma Malignant Lymphocytic | X| 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X X | 9 | Hepatocellular Carcinoma, Multiple | X X | 3 | Hepatocellular Adenoma | X X | 5 | Hepatocellular Adenoma, Multiple | X X | 3 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + A + + + + + + + A + + +| 45 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + A A + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + A A + + + + + + + + + + + + + +| 46 | Lymphoma Malignant Mixed | X | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + A + + + A + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Heart | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Mixed | X X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| | | 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + I + + + + + + + A + + + A + + + + + + + + + + +| 45 | Capsule, Lymphoma Malignant | | | Lymphocytic | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + I + + + + + + + A + + + A + + + + + + + + + + +| 45 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + I + + + + + I + A + + + A + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Islets, Pancreatic | + I + + + + + + + A + + I A + I + + + + I + + + +| 42 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + M + + A M M M M M + + M M + M M M + +| 24 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + A I I + I + I + + + + + M + I +| 37 | Pars Distalis, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + A A + + A + + + + + + + + + + +| 45 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + A M + + A + + + + + + + A + + +| 41 | __________________________________________________________________________|____________| Preputial Gland | + | 5 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + A + + + A + M + + + + + A + + +| 44 | __________________________________________________________________________|____________| Seminal Vesicle | + + + A + A A + | 15 | __________________________________________________________________________|____________| Testes | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + A + + + A + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + A + + + M + + + + + + + + + + +| 46 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | X | 1 | Mesenteric, Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + A + + + M + + + + + + + M + + +| 38 | Lymphoma Malignant Mixed | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M + + + + M M A + M + M + + M + M + M M + M +| 29 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Lymphocytic | X X X| 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| | | 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | X | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Thymus | M + M + + + M + + A A M + A + + + + + + + M M + +| 33 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M + + + M M + A M M + M M M M M M M M M M + M| 19 | __________________________________________________________________________|____________| Skin | + + + + + + + + + A + + I + + + + + + + + + + + +| 47 | Lymphoma Malignant Mixed | X | 1 | Tail, Schwannoma NOS | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + A + + + I + + + + + + + + + + +| 47 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X | 8 | Alveolar/Bronchiolar Carcinoma | X | 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X | 6 | Lymphoma Malignant Lymphocytic | X X| 2 | Lymphoma Malignant Mixed | X X X | 3 | __________________________________________________________________________|____________| Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + A A + + A + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + | 7 | Adenoma | X X X | 7 | __________________________________________________________________________|____________| Lacrimal Gland | + | 1 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | X| 1 | Lymphoma Malignant Mixed | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| | | 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cortex, Adenoma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X X X| 3 | Lymphoma Malignant Mixed | X X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0| | 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + M + + M A A + M + M M M + + + + M| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + A + + M + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + M + + + + + + + + + + + A + + M + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + M + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + M A + + M + + + + + +| __________________________________________________________________________| Intestine Small | + + + A + + + + + + + + + + + A + + M + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + M + + + + + A + + M + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + A + A M + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + M + + + + + A| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + M + + + + + +| Hemangiosarcoma | X X X | Hemangiosarcoma, Multiple | | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X X X| Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + M + + + + I +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + I M I +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + + + + I +| __________________________________________________________________________| Tooth | + | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0| | 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + I +| Capsule, Lymphoma Malignant | | Histiocytic | X | Subcapsular, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + + I +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + I + + + + I + + + + + + + M + I I + I +| Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Malignant| X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + + I + +| __________________________________________________________________________| Parathyroid Gland | + M + M + + M M + M + M + M + + M M M M M M M + M| __________________________________________________________________________| Pituitary Gland | + + I + + + + I + + + + + + + + + + M + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + M + + M M + +| __________________________________________________________________________| Preputial Gland | + + + + | Sarcoma | X | __________________________________________________________________________| Prostate | + + + + + M + + + + + M + + + + + + M + + + + I M| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + A + + M + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + + +| Sternal, Lymphoma Malignant | | Histiocytic | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + + +| Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mesenteric, Lymphoma Malignant | | Histiocytic | X | Mesenteric, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0| | 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphocytic | X X | Mesenteric, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Histiocytic| X | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + M M + + + + + + + M + + M M + M + + M + + M| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + M + M M M M + M M + + + M M M + + M + + M| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M + M + M + M M M M M M + M M + M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + M + + + M + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Skeletal Muscle | + | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + M + + + + + +| Meninges, Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + A + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X X X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 _____________________________________________________________________________________________________________________ | 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6| DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0| | 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + A A + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + A + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| | | 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | M + A + + I + + M M A + + + + M M + + + + A + + +| 32 | __________________________________________________________________________|____________| Intestine Large | + + A + + + + + + + + + + + + + A + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + M A + + + + + + + + + + + + + A + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + + + + + A + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + + + + + A + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small | + + A + + + + + + + + + + + + + A + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + M + + + + + + + + A + + A + + + + + + + +| 42 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + + + +| 44 | Lymphoma Malignant Lymphocytic | X X | 3 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A A + + + + + + + + + + + + A + + + + + + + +| 43 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 3 | Hemangiosarcoma, Multiple | X | 1 | Hepatocellular Carcinoma | X X X | 8 | Hepatocellular Carcinoma, Multiple | X | 4 | Hepatocellular Adenoma | X X X | 7 | Hepatocellular Adenoma, Multiple | X | 2 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Mesentery | + | 3 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Pancreas | + M + + + + + + + + + + + + + + A + + + + + + + +| 47 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Stomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Tooth | + + | 3 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| | | 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | Capsule, Lymphoma Malignant | | | Histiocytic | | 1 | Subcapsular, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | M M + + + + + + + + + + + + + + I + + + + + + + +| 41 | Pheochromocytoma Benign | | 1 | Bilateral, Pheochromocytoma Malignant| | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + M + + + + + + + + + + + + + + A + + + + + + + +| 46 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + M M M M M + M M M + + M M + M M + M M M M| 18 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 46 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + M + + + + + A M + + I + + M +| 42 | __________________________________________________________________________|____________| Preputial Gland | + + + + | 8 | Sarcoma | | 1 | __________________________________________________________________________|____________| Prostate | + M + + + + + + + + + + + + + + A + + + + + + + +| 43 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| 44 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| | | 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sternal, Lymphoma Malignant | | | Histiocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + M + + + + M + + + + + + + +| 47 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | X | 1 | Mesenteric, Lymphoma Malignant | | | Histiocytic | | 1 | Mesenteric, Lymphoma Malignant | | | Lymphocytic | X X | 4 | Mesenteric, Lymphoma Malignant Mixed | X X | 3 | Renal, Lymphoma Malignant Histiocytic| | 1 | Renal, Lymphoma Malignant Lymphocytic| X | 1 | Renal, Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + M + + + + M + M + + + + M + + M + + + + +| 36 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + M M + M M M + + M + M M + M + + +| 38 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Thymus | + + M + + M + + + M + M M M + M A + M + + + + + +| 29 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M M + M M + + M + M M M + + M M M M M + + + M| 15 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05097-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:50:05 __________________________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| | DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| | | 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | 4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 | Meninges, Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + A + + + + + + + + + + + + + A + + + + + + + +| 47 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X | 4 | Alveolar/Bronchiolar Carcinoma | X X X X X | 9 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 4 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Trachea | + + A + + + + + + + + + + + + + A + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + A + + + + + + + + + + + + + A + + + A + + +| 45 | __________________________________________________________________________|____________| Harderian Gland | +| 3 | Adenoma | X| 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + A + + + + + + + + + + + + + A + + + + + + + +| 47 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | X X | 4 | Lymphoma Malignant Mixed | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 503395-503395/503395 --multipart-boundary--