TDMS Study 05097-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) ALPHA-CHLOROACETOPHENONE NTP Experiment-Test: 05097-02 Report: PEIRPT05 Study Type: CHRONIC Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 Facility: Battelle Northwest Chemical CAS #: 532-27-4 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund 8 13 10 Dead 2 9 8 Survivors Terminal Sacrifice 40 27 32 Dead 1 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (45) (33) (39) Intestine Large, Cecum (49) (41) (42) Intestine Large, Colon (50) (47) (46) Intestine Large, Rectum (49) (47) (47) Intestine Small, Ileum (50) (45) (43) Intestine Small, Jejunum (50) (44) (43) Liver (50) (49) (49) Hepatoblastoma 1 (2%) Hepatocellular Carcinoma 6 (12%) 5 (10%) 4 (8%) Hepatocellular Carcinoma, Multiple 2 (4%) Hepatocellular Adenoma 4 (8%) 5 (10%) 2 (4%) Hepatocellular Adenoma, Multiple 3 (6%) 1 (2%) Histiocytic Sarcoma 2 (4%) Mesentery (16) (13) (19) Carcinoma, Metastatic, Uterus 1 (5%) Histiocytic Sarcoma 2 (11%) Pancreas (50) (48) (48) Salivary Glands (50) (50) (48) Histiocytic Sarcoma 1 (2%) Stomach, Forestomach (49) (48) (48) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) 2 (4%) Stomach, Glandular (50) (47) (48) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (49) Histiocytic Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (46) (48) Subcapsular, Adenoma 1 (2%) Adrenal Gland, Cortex (46) (44) (46) Adrenal Gland, Medulla (44) (38) (39) Pheochromocytoma NOS 1 (3%) Islets, Pancreatic (48) (46) (46) Adenoma 1 (2%) Pituitary Gland (45) (43) (45) Pars Distalis, Adenoma 20 (44%) 15 (35%) 12 (27%) Pars Distalis, Carcinoma 1 (2%) Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%) Thyroid Gland (49) (46) (49) Follicular Cell, Adenoma 2 (4%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (50) (44) (45) Granulosa Cell Tumor NOS 1 (2%) 1 (2%) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 2 (4%) Mixed Tumor Benign 1 (2%) Bilateral, Carcinoma, Metastatic, Uterus 1 (2%) Uterus (50) (49) (49) Carcinoma 1 (2%) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 1 (2%) Leiomyoma 1 (2%) Polyp 1 (2%) Sarcoma 1 (2%) Endometrium, Polyp 3 (6%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) (49) Lymph Node (50) (48) (46) Inguinal, Histiocytic Sarcoma 1 (2%) Mediastinal, Histiocytic Sarcoma 2 (4%) Mesenteric, Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Page 3 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Mesenteric, Histiocytic Sarcoma 1 (2%) 2 (4%) Renal, Histiocytic Sarcoma 1 (2%) Lymph Node, Bronchial (26) (38) (36) Histiocytic Sarcoma 3 (8%) Lymph Node, Mandibular (45) (41) (40) Histiocytic Sarcoma 2 (5%) Squamous Cell Carcinoma, Metastatic, Ear 1 (2%) Spleen (50) (48) (49) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 3 (6%) Sarcoma 1 (2%) Thymus (42) (37) (35) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (39) (37) (39) Adenoacanthoma 1 (3%) Adenocarcinoma 4 (10%) 1 (3%) 1 (3%) Fibroadenoma 1 (3%) Skin (50) (50) (48) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 1 (2%) Squamous Cell Papilloma 1 (2%) Subcutaneous Tissue, Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (48) (50) Rib, Osteosarcoma 1 (2%) Skeletal Muscle (1) (1) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (50) Carcinoma, Metastatic, Pituitary Gland 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (47) (49) Adenocarcinoma, Multiple, Metastatic, Harderian Gland 1 (2%) Alveolar/Bronchiolar Adenoma 4 (8%) 1 (2%) 4 (8%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) Page 4 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont Alveolar/Bronchiolar Carcinoma 3 (6%) 1 (2%) 1 (2%) Carcinoma, Metastatic, Liver 1 (2%) Carcinoma, Metastatic, Uterus 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 2 (4%) Histiocytic Sarcoma 3 (6%) Osteosarcoma, Multiple, Metastatic, Bone 1 (2%) Vein, Mediastinum, Hemangiosarcoma, Metastatic, Uterus 1 (2%) Trachea (49) (46) (49) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Ear (1) Squamous Cell Carcinoma 1 (100%) Harderian Gland (1) (1) (1) Adenocarcinoma 1 (100%) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (48) Histiocytic Sarcoma 1 (2%) Osteosarcoma, Multiple, Metastatic, Bone 1 (2%) Urinary Bladder (50) (47) (48) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 3 (6%) Lymphoma Malignant Histiocytic 7 (14%) 3 (6%) Lymphoma Malignant Lymphocytic 13 (26%) 14 (28%) 6 (12%) Lymphoma Malignant Mixed 2 (4%) 5 (10%) 3 (6%) Lymphoma Malignant Undifferentiated Cell 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3 FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 42 40 38 Total Primary Neoplasms 75 65 58 Total Animals with Benign Neoplasms 29 24 24 Total Benign Neoplasms 33 30 30 Total Animals with Malignant Neoplasms 30 29 25 Total Malignant Neoplasms 41 34 27 Total Animals with Metastatic Neoplasms 2 4 4 Total Metastatic Neoplasm 3 6 6 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 1 1 Total Uncertain Neoplasms 1 1 1 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Dead 5 9 11 Moribund 11 5 6 Survivors Terminal Sacrifice 34 36 33 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (41) (36) (32) Hepatocellular Carcinoma, Metastatic, Liver 1 (3%) Intestine Small, Duodenum (46) (44) (42) Adenoma 1 (2%) Intestine Small, Ileum (48) (44) (44) Intestine Small, Jejunum (46) (43) (43) Adenocarcinoma 1 (2%) Liver (50) (48) (49) Hemangiosarcoma 1 (2%) 3 (6%) Hemangiosarcoma, Multiple 1 (2%) Hepatocellular Carcinoma 6 (12%) 9 (19%) 8 (16%) Hepatocellular Carcinoma, Multiple 5 (10%) 3 (6%) 4 (8%) Hepatocellular Adenoma 4 (8%) 5 (10%) 7 (14%) Hepatocellular Adenoma, Multiple 1 (2%) 3 (6%) 2 (4%) Mesentery (3) Pancreas (50) (45) (47) Hemangioma 1 (2%) Salivary Glands (50) (48) (49) Stomach, Forestomach (49) (46) (45) Squamous Cell Papilloma 2 (4%) 1 (2%) Stomach, Glandular (50) (44) (47) Tooth (5) (1) (3) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (49) (49) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (50) (45) (47) Subcapsular, Adenoma 1 (2%) 1 (2%) Adrenal Gland, Cortex (50) (45) (47) Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Adrenal Gland, Medulla (48) (44) (41) Pheochromocytoma NOS 1 (2%) Pheochromocytoma Benign 1 (2%) Bilateral, Pheochromocytoma Malignant 1 (2%) Islets, Pancreatic (50) (42) (46) Adenoma 1 (2%) Pituitary Gland (44) (37) (46) Pars Distalis, Adenoma 1 (3%) Thyroid Gland (50) (45) (48) Follicular Cell, Adenoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) (1) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (47) (41) (42) Sarcoma 1 (2%) Preputial Gland (10) (5) (8) Sarcoma 1 (13%) Prostate (50) (44) (43) Seminal Vesicle (49) (15) (44) Testes (50) (44) (47) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (48) (49) Lymph Node (48) (46) (47) Lymph Node, Bronchial (35) (38) (36) Lymph Node, Mandibular (41) (29) (38) Hemangiosarcoma, Metastatic, Spleen 1 (2%) Spleen (50) (47) (49) Hemangiosarcoma 1 (2%) Sarcoma 1 (2%) Thymus (28) (33) (29) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (47) (47) Tail, Schwannoma NOS 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (49) Skeletal Muscle (1) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (49) (48) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (47) (47) Lung (50) (49) (49) Alveolar/Bronchiolar Adenoma 7 (14%) 8 (16%) 4 (8%) Alveolar/Bronchiolar Carcinoma 6 (12%) 3 (6%) 9 (18%) Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) 6 (12%) 4 (8%) Nose (50) (48) (48) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (4) (7) (3) Adenoma 3 (75%) 7 (100%) 3 (100%) Sarcoma 1 (25%) Lacrimal Gland (1) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (49) Cortex, Adenoma 1 (2%) 1 (2%) Urinary Bladder (49) (44) (47) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Lymphoma Malignant Histiocytic 2 (4%) 1 (2%) Lymphoma Malignant Lymphocytic 2 (4%) 3 (6%) 4 (8%) Lymphoma Malignant Mixed 1 (2%) 3 (6%) 3 (6%) * Number of animals with any tissue examined microscopically Page 9 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont Multiple Organs *(50) *(50) *(50) Lymphoma Malignant Undifferentiated Cell 1 (2%) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3 MALE MALE MALE ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 33 35 39 Total Primary Neoplasms 49 52 54 Total Animals with Benign Neoplasms 17 21 17 Total Benign Neoplasms 21 28 19 Total Animals with Malignant Neoplasms 23 23 29 Total Malignant Neoplasms 27 23 35 Total Animals with Metastatic Neoplasms 4 6 4 Total Metastatic Neoplasm 4 8 4 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 1 Total Uncertain Neoplasms 1 1 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT 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