TDMS Study 05097-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ALPHA-CHLOROACETOPHENONE
NTP Experiment-Test: 05097-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
Facility: Battelle Northwest
Chemical CAS #: 532-27-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 8 13 10
Dead 2 9 8
Survivors
Terminal Sacrifice 40 27 32
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (33) (39)
Intestine Large, Cecum (49) (41) (42)
Intestine Large, Colon (50) (47) (46)
Intestine Large, Rectum (49) (47) (47)
Intestine Small, Ileum (50) (45) (43)
Intestine Small, Jejunum (50) (44) (43)
Liver (50) (49) (49)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 6 (12%) 5 (10%) 4 (8%)
Hepatocellular Carcinoma, Multiple 2 (4%)
Hepatocellular Adenoma 4 (8%) 5 (10%) 2 (4%)
Hepatocellular Adenoma, Multiple 3 (6%) 1 (2%)
Histiocytic Sarcoma 2 (4%)
Mesentery (16) (13) (19)
Carcinoma, Metastatic, Uterus 1 (5%)
Histiocytic Sarcoma 2 (11%)
Pancreas (50) (48) (48)
Salivary Glands (50) (50) (48)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (49) (48) (48)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%)
Stomach, Glandular (50) (47) (48)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (46) (48)
Subcapsular, Adenoma 1 (2%)
Adrenal Gland, Cortex (46) (44) (46)
Adrenal Gland, Medulla (44) (38) (39)
Pheochromocytoma NOS 1 (3%)
Islets, Pancreatic (48) (46) (46)
Adenoma 1 (2%)
Pituitary Gland (45) (43) (45)
Pars Distalis, Adenoma 20 (44%) 15 (35%) 12 (27%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (49) (46) (49)
Follicular Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (44) (45)
Granulosa Cell Tumor NOS 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 2 (4%)
Mixed Tumor Benign 1 (2%)
Bilateral, Carcinoma, Metastatic, Uterus 1 (2%)
Uterus (50) (49) (49)
Carcinoma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (2%)
Polyp 1 (2%)
Sarcoma 1 (2%)
Endometrium, Polyp 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48) (49)
Lymph Node (50) (48) (46)
Inguinal, Histiocytic Sarcoma 1 (2%)
Mediastinal, Histiocytic Sarcoma 2 (4%)
Mesenteric, Hepatocellular Carcinoma,
Metastatic, Liver 1 (2%)
Page 3
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Mesenteric, Histiocytic Sarcoma 1 (2%) 2 (4%)
Renal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Bronchial (26) (38) (36)
Histiocytic Sarcoma 3 (8%)
Lymph Node, Mandibular (45) (41) (40)
Histiocytic Sarcoma 2 (5%)
Squamous Cell Carcinoma, Metastatic, Ear 1 (2%)
Spleen (50) (48) (49)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 3 (6%)
Sarcoma 1 (2%)
Thymus (42) (37) (35)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (37) (39)
Adenoacanthoma 1 (3%)
Adenocarcinoma 4 (10%) 1 (3%) 1 (3%)
Fibroadenoma 1 (3%)
Skin (50) (50) (48)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (48) (50)
Rib, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (47) (49)
Adenocarcinoma, Multiple, Metastatic,
Harderian Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 4 (8%) 1 (2%) 4 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Page 4
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Alveolar/Bronchiolar Carcinoma 3 (6%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Liver 1 (2%)
Carcinoma, Metastatic, Uterus 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 2 (4%)
Histiocytic Sarcoma 3 (6%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Vein, Mediastinum, Hemangiosarcoma,
Metastatic, Uterus 1 (2%)
Trachea (49) (46) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Squamous Cell Carcinoma 1 (100%)
Harderian Gland (1) (1) (1)
Adenocarcinoma 1 (100%)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (48)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Urinary Bladder (50) (47) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 3 (6%)
Lymphoma Malignant Histiocytic 7 (14%) 3 (6%)
Lymphoma Malignant Lymphocytic 13 (26%) 14 (28%) 6 (12%)
Lymphoma Malignant Mixed 2 (4%) 5 (10%) 3 (6%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 2 MG/M3 4 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 42 40 38
Total Primary Neoplasms 75 65 58
Total Animals with Benign Neoplasms 29 24 24
Total Benign Neoplasms 33 30 30
Total Animals with Malignant Neoplasms 30 29 25
Total Malignant Neoplasms 41 34 27
Total Animals with Metastatic Neoplasms 2 4 4
Total Metastatic Neoplasm 3 6 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 1 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 5 9 11
Moribund 11 5 6
Survivors
Terminal Sacrifice 34 36 33
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (41) (36) (32)
Hepatocellular Carcinoma, Metastatic, Liver 1 (3%)
Intestine Small, Duodenum (46) (44) (42)
Adenoma 1 (2%)
Intestine Small, Ileum (48) (44) (44)
Intestine Small, Jejunum (46) (43) (43)
Adenocarcinoma 1 (2%)
Liver (50) (48) (49)
Hemangiosarcoma 1 (2%) 3 (6%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 6 (12%) 9 (19%) 8 (16%)
Hepatocellular Carcinoma, Multiple 5 (10%) 3 (6%) 4 (8%)
Hepatocellular Adenoma 4 (8%) 5 (10%) 7 (14%)
Hepatocellular Adenoma, Multiple 1 (2%) 3 (6%) 2 (4%)
Mesentery (3)
Pancreas (50) (45) (47)
Hemangioma 1 (2%)
Salivary Glands (50) (48) (49)
Stomach, Forestomach (49) (46) (45)
Squamous Cell Papilloma 2 (4%) 1 (2%)
Stomach, Glandular (50) (44) (47)
Tooth (5) (1) (3)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (49)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (45) (47)
Subcapsular, Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Cortex (50) (45) (47)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Adrenal Gland, Medulla (48) (44) (41)
Pheochromocytoma NOS 1 (2%)
Pheochromocytoma Benign 1 (2%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Islets, Pancreatic (50) (42) (46)
Adenoma 1 (2%)
Pituitary Gland (44) (37) (46)
Pars Distalis, Adenoma 1 (3%)
Thyroid Gland (50) (45) (48)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (47) (41) (42)
Sarcoma 1 (2%)
Preputial Gland (10) (5) (8)
Sarcoma 1 (13%)
Prostate (50) (44) (43)
Seminal Vesicle (49) (15) (44)
Testes (50) (44) (47)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48) (49)
Lymph Node (48) (46) (47)
Lymph Node, Bronchial (35) (38) (36)
Lymph Node, Mandibular (41) (29) (38)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Spleen (50) (47) (49)
Hemangiosarcoma 1 (2%)
Sarcoma 1 (2%)
Thymus (28) (33) (29)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (47) (47)
Tail, Schwannoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (48)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (47) (47)
Lung (50) (49) (49)
Alveolar/Bronchiolar Adenoma 7 (14%) 8 (16%) 4 (8%)
Alveolar/Bronchiolar Carcinoma 6 (12%) 3 (6%) 9 (18%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%) 6 (12%) 4 (8%)
Nose (50) (48) (48)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (4) (7) (3)
Adenoma 3 (75%) 7 (100%) 3 (100%)
Sarcoma 1 (25%)
Lacrimal Gland (1)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49)
Cortex, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (49) (44) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 2 (4%) 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 3 (6%) 4 (8%)
Lymphoma Malignant Mixed 1 (2%) 3 (6%) 3 (6%)
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05097-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:07:42
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 2 MG/M3 4 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 33 35 39
Total Primary Neoplasms 49 52 54
Total Animals with Benign Neoplasms 17 21 17
Total Benign Neoplasms 21 28 19
Total Animals with Malignant Neoplasms 23 23 29
Total Malignant Neoplasms 27 23 35
Total Animals with Metastatic Neoplasms 4 6 4
Total Metastatic Neoplasm 4 8 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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