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TDMS Study 05097-02 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                      ALPHA-CHLOROACETOPHENONE


NTP Experiment-Test: 05097-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42




       Facility:  Battelle Northwest

       Chemical CAS #:  532-27-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                           8           13           10                                                  
    Dead                                               2            9            8                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           27           32                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (33)         (39)                                                
   Intestine Large, Cecum                             (49)         (41)         (42)                                                
   Intestine Large, Colon                             (50)         (47)         (46)                                                
   Intestine Large, Rectum                            (49)         (47)         (47)                                                
   Intestine Small, Ileum                             (50)         (45)         (43)                                                
   Intestine Small, Jejunum                           (50)         (44)         (43)                                                
   Liver                                              (50)         (49)         (49)                                                
      Hepatoblastoma                                                1 (2%)                                                          
      Hepatocellular Carcinoma                         6 (12%)      5 (10%)      4 (8%)                                             
      Hepatocellular Carcinoma, Multiple               2 (4%)                                                                       
      Hepatocellular Adenoma                           4 (8%)       5 (10%)      2 (4%)                                             
      Hepatocellular Adenoma, Multiple                              3 (6%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        2 (4%)                                             
   Mesentery                                          (16)         (13)         (19)                                                
      Carcinoma, Metastatic, Uterus                                              1 (5%)                                             
      Histiocytic Sarcoma                                                        2 (11%)                                            
   Pancreas                                           (50)         (48)         (48)                                                
   Salivary Glands                                    (50)         (50)         (48)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (49)         (48)         (48)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)       2 (4%)                                             
   Stomach, Glandular                                 (50)         (47)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (46)         (48)                                                
      Subcapsular, Adenoma                                          1 (2%)                                                          
   Adrenal Gland, Cortex                              (46)         (44)         (46)                                                
   Adrenal Gland, Medulla                             (44)         (38)         (39)                                                
      Pheochromocytoma NOS                                          1 (3%)                                                          
   Islets, Pancreatic                                 (48)         (46)         (46)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (45)         (43)         (45)                                                
      Pars Distalis, Adenoma                          20 (44%)     15 (35%)     12 (27%)                                            
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (49)         (46)         (49)                                                
      Follicular Cell, Adenoma                                                   2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (44)         (45)                                                
      Granulosa Cell Tumor NOS                         1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Mixed Tumor Benign                                                         1 (2%)                                             
      Bilateral, Carcinoma, Metastatic, Uterus                                   1 (2%)                                             
   Uterus                                             (50)         (49)         (49)                                                
      Carcinoma                                                                  1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyoma                                                                  1 (2%)                                             
      Polyp                                                         1 (2%)                                                          
      Sarcoma                                          1 (2%)                                                                       
      Endometrium, Polyp                               3 (6%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (48)         (49)                                                
   Lymph Node                                         (50)         (48)         (46)                                                
      Inguinal, Histiocytic Sarcoma                                              1 (2%)                                             
      Mediastinal, Histiocytic Sarcoma                                           2 (4%)                                             
      Mesenteric, Hepatocellular Carcinoma,                                                                                         
          Metastatic, Liver                                         1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mesenteric, Histiocytic Sarcoma                  1 (2%)                    2 (4%)                                             
      Renal, Histiocytic Sarcoma                                                 1 (2%)                                             
   Lymph Node, Bronchial                              (26)         (38)         (36)                                                
      Histiocytic Sarcoma                                                        3 (8%)                                             
   Lymph Node, Mandibular                             (45)         (41)         (40)                                                
      Histiocytic Sarcoma                                                        2 (5%)                                             
      Squamous Cell Carcinoma, Metastatic, Ear         1 (2%)                                                                       
   Spleen                                             (50)         (48)         (49)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                                        3 (6%)                                             
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (42)         (37)         (35)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (39)         (37)         (39)                                                
      Adenoacanthoma                                                1 (3%)                                                          
      Adenocarcinoma                                   4 (10%)      1 (3%)       1 (3%)                                             
      Fibroadenoma                                     1 (3%)                                                                       
   Skin                                               (50)         (50)         (48)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (48)         (50)                                                
      Rib, Osteosarcoma                                             1 (2%)                                                          
   Skeletal Muscle                                                 (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (47)         (49)                                                
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Harderian Gland                                                        1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (2%)       4 (8%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
                                                             Page   4                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Liver                                  1 (2%)                                                          
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       2 (4%)                                                          
      Histiocytic Sarcoma                                                        3 (6%)                                             
      Osteosarcoma, Multiple, Metastatic, Bone                      1 (2%)                                                          
      Vein, Mediastinum, Hemangiosarcoma,                                                                                           
          Metastatic, Uterus                                                     1 (2%)                                             
   Trachea                                            (49)         (46)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
   Harderian Gland                                    (1)          (1)          (1)                                                 
      Adenocarcinoma                                                             1 (100%)                                           
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (48)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Multiple, Metastatic, Bone                      1 (2%)                                                          
   Urinary Bladder                                    (50)         (47)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                    3 (6%)                                             
      Lymphoma Malignant Histiocytic                   7 (14%)                   3 (6%)                                             
      Lymphoma Malignant Lymphocytic                  13 (26%)     14 (28%)      6 (12%)                                            
      Lymphoma Malignant Mixed                         2 (4%)       5 (10%)      3 (6%)                                             
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      2 MG/M3      4 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          40          38                                                   
     Total Primary Neoplasms                           75          65          58                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          24          24                                                   
     Total Benign Neoplasms                            33          30          30                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          29          25                                                   
     Total Malignant Neoplasms                         41          34          27                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           4           4                                                   
     Total Metastatic Neoplasm                          3           6           6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           1                                                   
     Total Uncertain Neoplasms                          1           1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               5            9           11                                                  
    Moribund                                          11            5            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           36           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (41)         (36)         (32)                                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (3%)                                                          
   Intestine Small, Duodenum                          (46)         (44)         (42)                                                
      Adenoma                                          1 (2%)                                                                       
   Intestine Small, Ileum                             (48)         (44)         (44)                                                
   Intestine Small, Jejunum                           (46)         (43)         (43)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (48)         (49)                                                
      Hemangiosarcoma                                               1 (2%)       3 (6%)                                             
      Hemangiosarcoma, Multiple                                                  1 (2%)                                             
      Hepatocellular Carcinoma                         6 (12%)      9 (19%)      8 (16%)                                            
      Hepatocellular Carcinoma, Multiple               5 (10%)      3 (6%)       4 (8%)                                             
      Hepatocellular Adenoma                           4 (8%)       5 (10%)      7 (14%)                                            
      Hepatocellular Adenoma, Multiple                 1 (2%)       3 (6%)       2 (4%)                                             
   Mesentery                                                                    (3)                                                 
   Pancreas                                           (50)         (45)         (47)                                                
      Hemangioma                                       1 (2%)                                                                       
   Salivary Glands                                    (50)         (48)         (49)                                                
   Stomach, Forestomach                               (49)         (46)         (45)                                                
      Squamous Cell Papilloma                          2 (4%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (44)         (47)                                                
   Tooth                                              (5)          (1)          (3)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (45)         (47)                                                
      Subcapsular, Adenoma                             1 (2%)                    1 (2%)                                             
   Adrenal Gland, Cortex                              (50)         (45)         (47)                                                
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Adrenal Gland, Medulla                             (48)         (44)         (41)                                                
      Pheochromocytoma NOS                             1 (2%)                                                                       
      Pheochromocytoma Benign                                                    1 (2%)                                             
      Bilateral, Pheochromocytoma Malignant                                      1 (2%)                                             
   Islets, Pancreatic                                 (50)         (42)         (46)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (44)         (37)         (46)                                                
      Pars Distalis, Adenoma                                        1 (3%)                                                          
   Thyroid Gland                                      (50)         (45)         (48)                                                
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (47)         (41)         (42)                                                
      Sarcoma                                          1 (2%)                                                                       
   Preputial Gland                                    (10)         (5)          (8)                                                 
      Sarcoma                                                                    1 (13%)                                            
   Prostate                                           (50)         (44)         (43)                                                
   Seminal Vesicle                                    (49)         (15)         (44)                                                
   Testes                                             (50)         (44)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (48)         (49)                                                
   Lymph Node                                         (48)         (46)         (47)                                                
   Lymph Node, Bronchial                              (35)         (38)         (36)                                                
   Lymph Node, Mandibular                             (41)         (29)         (38)                                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
   Spleen                                             (50)         (47)         (49)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (28)         (33)         (29)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (47)         (47)                                                
      Tail, Schwannoma NOS                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
   Skeletal Muscle                                                              (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (47)         (47)                                                
   Lung                                               (50)         (49)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     7 (14%)      8 (16%)      4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   6 (12%)      3 (6%)       9 (18%)                                            
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       6 (12%)      4 (8%)                                             
   Nose                                               (50)         (48)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (7)          (3)                                                 
      Adenoma                                          3 (75%)      7 (100%)     3 (100%)                                           
      Sarcoma                                          1 (25%)                                                                      
   Lacrimal Gland                                                  (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)                                                
      Cortex, Adenoma                                  1 (2%)       1 (2%)                                                          
   Urinary Bladder                                    (49)         (44)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   2 (4%)                    1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   2 (4%)       3 (6%)       4 (8%)                                             
      Lymphoma Malignant Mixed                         1 (2%)       3 (6%)       3 (6%)                                             
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05097-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:07:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      2 MG/M3      4 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            33          35          39                                                   
     Total Primary Neoplasms                           49          52          54                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          21          17                                                   
     Total Benign Neoplasms                            21          28          19                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          23          29                                                   
     Total Malignant Neoplasms                         27          23          35                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           6           4                                                   
     Total Metastatic Neoplasm                          4           8           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1                                                               
     Total Uncertain Neoplasms                          1           1                                                               
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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