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TDMS Study 05097-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                 ALPHA-CHLOROACETOPHENONE                               DATE: 09/13/94       
EXPERIMENT: 05097 TEST: 02                                                                                     TIME: 08:20:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-38061          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 55107        
PATHOLOGIST: R. BUSCH                                                                                          CAS: 532-27-4        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Battelle Northwest                                 ALPHA-CHLOROACETOPHENONE                               DATE: 09/13/94      
EXPERIMENT: 05097 TEST: 02                                                                                     TIME: 08:20:46      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-38061          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 55107       
PATHOLOGIST: R. BUSCH                                                                                          CAS: 532-27-4       
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                 ALPHA-CHLOROACETOPHENONE                               DATE: 09/13/94       
EXPERIMENT: 05097 TEST: 02                                                                                     TIME: 08:20:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-38061          ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                                             NTP C#: 55107        
PATHOLOGIST: R. BUSCH                                                                                          CAS: 532-27-4        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                    IN THE ANALYSIS OF THE STUDY OF ALPHA-CHLOROACETOPHENONE
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hemangiosarcoma
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Mammary Gland                 Fibroma, Fibroadenoma, Carcinoma, or Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             All Organs                    Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
 
              ====================================================================================================
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   1
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/48 (2%)       0/44 (0%)       2/41 (5%)      |     0/44 (0%)       1/38 (3%)       0/39 (0%)      |
|ADJUSTED (b)           |      3.0%            0.0%            7.1%          |      0.0%            4.3%            0.0%          |
|TERMINAL (d)           |     1/33 (3%)       0/35 (0%)       2/28 (7%)      |     0/35 (0%)       1/23 (4%)       0/25 (0%)      |
|FIRST INCIDENCE (DAYS) |      736 (T)         ---             736 (T)       |      ---             735 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.315         P=0.488N        P=0.442        |     P=0.674         P=0.416           (e)          |
|INCIDENTAL TUMOR       |     P=0.315         P=0.488N        P=0.442        |     P=0.674         P=0.416           (e)          |
|LOGISTIC REGRESSION    |     P=0.315         P=0.488N        P=0.442        |     P=0.674         P=0.416           (e)          |
|COCHRAN-ARMITAGE       |     P=0.319                                        |     P=0.711                                        |
|FISHER EXACT           |                     P=0.522N        P=0.440        |                     P=0.463           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       7/50 (14%)      3/50 (6%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      8.0%           18.8%            9.1%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/34 (6%)       6/36 (17%)      3/33 (9%)      |     0/40 (0%)       0/28 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      666             676             736 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.547         P=0.171         P=0.642        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.531         P=0.089         P=0.635        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.533         P=0.132         P=0.637        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.571N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.159         P=0.661N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   2
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/50 (6%)       7/50 (14%)      3/50 (6%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      8.0%           18.8%            9.1%          |      0.0%            3.6%            3.1%          |
|TERMINAL (d)           |     2/34 (6%)       6/36 (17%)      3/33 (9%)      |     0/40 (0%)       1/28 (4%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      666             676             736 (T)       |      ---             735 (T)         735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.547         P=0.171         P=0.642        |     P=0.289         P=0.429         P=0.455        |
|INCIDENTAL TUMOR       |     P=0.531         P=0.089         P=0.635        |     P=0.289         P=0.429         P=0.455        |
|LOGISTIC REGRESSION    |     P=0.533         P=0.132         P=0.637        |     P=0.289         P=0.429         P=0.455        |
|COCHRAN-ARMITAGE       |     P=0.571N                                       |     P=0.331                                        |
|FISHER EXACT           |                     P=0.159         P=0.661N       |                     P=0.500         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      5.6%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/34 (3%)       0/36 (0%)       0/33 (0%)      |     0/40 (0%)       0/28 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      730             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.099N        P=0.231N        P=0.249N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.127N        P=0.362N        P=0.265N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.103N        P=0.250N        P=0.253N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.095N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.247N        P=0.247N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   3
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/48 (2%)       4/49 (8%)      |     0/50 (0%)       0/49 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |      0.0%            2.8%           10.5%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/34 (0%)       1/36 (3%)       2/33 (6%)      |     0/40 (0%)       0/28 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             736 (T)         604           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.025 *       P=0.511         P=0.061        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.028 *       P=0.511         P=0.069        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.024 *       P=0.511         P=0.062        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.025 *                                      |       (e)                                          |
|FISHER EXACT           |                     P=0.490         P=0.056        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/50 (10%)      8/48 (17%)      9/49 (18%)     |     4/50 (8%)       8/49 (16%)      3/49 (6%)      |
|ADJUSTED (b)           |     12.5%           20.1%           22.6%          |     10.0%           25.0%            9.4%          |
|TERMINAL (d)           |     3/34 (9%)       5/36 (14%)      4/33 (12%)     |     4/40 (10%)      6/28 (21%)      3/32 (9%)      |
|FIRST INCIDENCE (DAYS) |      514             559             339           |      735 (T)         403             735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.155         P=0.285         P=0.187        |     P=0.550         P=0.066         P=0.621N       |
|INCIDENTAL TUMOR       |     P=0.223         P=0.362         P=0.257        |     P=0.543N        P=0.092         P=0.621N       |
|LOGISTIC REGRESSION    |     P=0.183         P=0.294         P=0.232        |     P=0.490N        P=0.160         P=0.621N       |
|COCHRAN-ARMITAGE       |     P=0.152                                        |     P=0.447N                                       |
|FISHER EXACT           |                     P=0.250         P=0.183        |                     P=0.168         P=0.511N       |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   4
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/50 (22%)     12/48 (25%)     12/49 (24%)     |     8/50 (16%)      5/49 (10%)      4/49 (8%)      |
|ADJUSTED (b)           |     25.9%           25.6%           29.0%          |     18.3%           14.1%            9.7%          |
|TERMINAL (d)           |     4/34 (12%)      4/36 (11%)      6/33 (18%)     |     5/40 (13%)      2/28 (7%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      535             470             339           |      423             493             382           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.410         P=0.487         P=0.451        |     P=0.234N        P=0.478N        P=0.280N       |
|INCIDENTAL TUMOR       |     P=0.434         P=0.512         P=0.505        |     P=0.097N        P=0.216N        P=0.113N       |
|LOGISTIC REGRESSION    |     P=0.456         P=0.521N        P=0.564        |     P=0.093N        P=0.246N        P=0.119N       |
|COCHRAN-ARMITAGE       |     P=0.431                                        |     P=0.143N                                       |
|FISHER EXACT           |                     P=0.455         P=0.478        |                     P=0.290N        P=0.188N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/50 (22%)     12/48 (25%)     12/49 (24%)     |     8/50 (16%)      6/49 (12%)      4/49 (8%)      |
|ADJUSTED (b)           |     25.9%           25.6%           29.0%          |     18.3%           16.1%            9.7%          |
|TERMINAL (d)           |     4/34 (12%)      4/36 (11%)      6/33 (18%)     |     5/40 (13%)      2/28 (7%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      535             470             339           |      423             493             382           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.410         P=0.487         P=0.451        |     P=0.243N        P=0.592N        P=0.280N       |
|INCIDENTAL TUMOR       |     P=0.434         P=0.512         P=0.505        |     P=0.088N        P=0.271N        P=0.113N       |
|LOGISTIC REGRESSION    |     P=0.456         P=0.521N        P=0.564        |     P=0.091N        P=0.335N        P=0.119N       |
|COCHRAN-ARMITAGE       |     P=0.431                                        |     P=0.149N                                       |
|FISHER EXACT           |                     P=0.455         P=0.478        |                     P=0.403N        P=0.188N       |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   5
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    16/50 (32%)     19/48 (40%)     20/49 (41%)     |    12/50 (24%)     13/49 (27%)      7/49 (14%)     |
|ADJUSTED (b)           |     36.0%           39.6%           45.6%          |     27.7%           37.0%           18.4%          |
|TERMINAL (d)           |     7/34 (21%)      8/36 (22%)     10/33 (30%)     |     9/40 (23%)      8/28 (29%)      4/32 (13%)     |
|FIRST INCIDENCE (DAYS) |      514             470             339           |      423             403             382           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.225         P=0.351         P=0.249        |     P=0.298N        P=0.210         P=0.295N       |
|INCIDENTAL TUMOR       |     P=0.194         P=0.391         P=0.243        |     P=0.154N        P=0.434         P=0.149N       |
|LOGISTIC REGRESSION    |     P=0.193         P=0.471         P=0.222        |     P=0.123N        P=0.509         P=0.144N       |
|COCHRAN-ARMITAGE       |     P=0.211                                        |     P=0.148N                                       |
|FISHER EXACT           |                     P=0.284         P=0.241        |                     P=0.477         P=0.166N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    16/50 (32%)     19/48 (40%)     20/49 (41%)     |    12/50 (24%)     14/49 (29%)      7/49 (14%)     |
|ADJUSTED (b)           |     36.0%           39.6%           45.6%          |     27.7%           38.4%           18.4%          |
|TERMINAL (d)           |     7/34 (21%)      8/36 (22%)     10/33 (30%)     |     9/40 (23%)      8/28 (29%)      4/32 (13%)     |
|FIRST INCIDENCE (DAYS) |      514             470             339           |      423             403             382           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.225         P=0.351         P=0.249        |     P=0.303N        P=0.156         P=0.295N       |
|INCIDENTAL TUMOR       |     P=0.194         P=0.391         P=0.243        |     P=0.143N        P=0.390         P=0.149N       |
|LOGISTIC REGRESSION    |     P=0.193         P=0.471         P=0.222        |     P=0.119N        P=0.434         P=0.144N       |
|COCHRAN-ARMITAGE       |     P=0.211                                        |     P=0.151N                                       |
|FISHER EXACT           |                     P=0.284         P=0.241        |                     P=0.387         P=0.166N       |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   6
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      8/49 (16%)      4/49 (8%)      |     4/50 (8%)       1/47 (2%)       5/49 (10%)     |
|ADJUSTED (b)           |     19.9%           21.0%           11.0%          |      9.5%            3.7%           15.6%          |
|TERMINAL (d)           |     6/34 (18%)      6/36 (17%)      2/33 (6%)      |     3/40 (8%)       1/27 (4%)       5/32 (16%)     |
|FIRST INCIDENCE (DAYS) |      730             676             661           |      590             735 (T)         735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.249N        P=0.538         P=0.286N       |     P=0.313         P=0.291N        P=0.371        |
|INCIDENTAL TUMOR       |     P=0.284N        P=0.345         P=0.307N       |     P=0.347         P=0.206N        P=0.435        |
|LOGISTIC REGRESSION    |     P=0.268N        P=0.437         P=0.301N       |     P=0.347         P=0.208N        P=0.423        |
|COCHRAN-ARMITAGE       |     P=0.238N                                       |     P=0.411                                        |
|FISHER EXACT           |                     P=0.483         P=0.274N       |                     P=0.201N        P=0.487        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      3/49 (6%)       9/49 (18%)     |     3/50 (6%)       1/47 (2%)       1/49 (2%)      |
|ADJUSTED (b)           |     17.1%            8.3%           26.0%          |      6.9%            3.7%            3.1%          |
|TERMINAL (d)           |     5/34 (15%)      3/36 (8%)       8/33 (24%)     |     1/40 (3%)       1/27 (4%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      730             736 (T)         643           |      590             735 (T)         735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.200         P=0.217N        P=0.264        |     P=0.270N        P=0.418N        P=0.376N       |
|INCIDENTAL TUMOR       |     P=0.206         P=0.277N        P=0.277        |     P=0.192N        P=0.221N        P=0.252N       |
|LOGISTIC REGRESSION    |     P=0.181         P=0.242N        P=0.236        |     P=0.221N        P=0.323N        P=0.311N       |
|COCHRAN-ARMITAGE       |     P=0.210                                        |     P=0.209N                                       |
|FISHER EXACT           |                     P=0.254N        P=0.274        |                     P=0.332N        P=0.316N       |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   7
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/50 (22%)      9/49 (18%)     13/49 (27%)     |     6/50 (12%)      2/47 (4%)       6/49 (12%)     |
|ADJUSTED (b)           |     31.4%           23.6%           35.5%          |     14.1%            7.4%           18.8%          |
|TERMINAL (d)           |    10/34 (29%)      7/36 (19%)     10/33 (30%)     |     4/40 (10%)      2/27 (7%)       6/32 (19%)     |
|FIRST INCIDENCE (DAYS) |      730             676             643           |      590             735 (T)         735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.326         P=0.355N        P=0.372        |     P=0.424         P=0.273N        P=0.468        |
|INCIDENTAL TUMOR       |     P=0.307         P=0.524N        P=0.370        |     P=0.474         P=0.156N        P=0.550        |
|LOGISTIC REGRESSION    |     P=0.288         P=0.469N        P=0.329        |     P=0.464         P=0.183N        P=0.524        |
|COCHRAN-ARMITAGE       |     P=0.339                                        |     P=0.555                                        |
|FISHER EXACT           |                     P=0.421N        P=0.385        |                     P=0.155N        P=0.606        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     4/50 (8%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     10.0%            3.3%            2.3%          |
|TERMINAL (d)           |     0/34 (0%)       0/36 (0%)       0/33 (0%)      |     4/40 (10%)      0/28 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      735 (T)         720             583           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.154N        P=0.299N        P=0.245N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.098N        P=0.217N        P=0.167N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.115N        P=0.269N        P=0.190N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.101N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.181N        P=0.181N       |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   8
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     5/50 (10%)      1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     12.5%            3.3%            2.3%          |
|TERMINAL (d)           |     0/34 (0%)       0/36 (0%)       0/33 (0%)      |     5/40 (13%)      0/28 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      735 (T)         720             583           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.086N        P=0.202N        P=0.156N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.051N        P=0.142N        P=0.103N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.060N        P=0.177N        P=0.117N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.049N*                                      |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.102N        P=0.102N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/44 (0%)       1/37 (3%)       0/46 (0%)      |    20/45 (44%)     15/43 (35%)     12/45 (27%)     |
|ADJUSTED (b)           |      0.0%            3.3%            0.0%          |     52.4%           54.7%           35.6%          |
|TERMINAL (d)           |     0/33 (0%)       1/30 (3%)       0/31 (0%)      |    18/36 (50%)     12/24 (50%)      9/30 (30%)     |
|FIRST INCIDENCE (DAYS) |      ---             736 (T)         ---           |      715             685             646           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.719         P=0.481           (e)          |     P=0.178N        P=0.431         P=0.190N       |
|INCIDENTAL TUMOR       |     P=0.719         P=0.481           (e)          |     P=0.094N        P=0.486N        P=0.100N       |
|LOGISTIC REGRESSION    |     P=0.719         P=0.481           (e)          |     P=0.113N        P=0.567         P=0.119N       |
|COCHRAN-ARMITAGE       |     P=0.718N                                       |     P=0.049N*                                      |
|FISHER EXACT           |                     P=0.457           (e)          |                     P=0.243N        P=0.061N       |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE   9
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/44 (0%)       1/37 (3%)       0/46 (0%)      |    20/45 (44%)     15/43 (35%)     13/45 (29%)     |
|ADJUSTED (b)           |      0.0%            3.3%            0.0%          |     52.4%           54.7%           37.1%          |
|TERMINAL (d)           |     0/33 (0%)       1/30 (3%)       0/31 (0%)      |    18/36 (50%)     12/24 (50%)      9/30 (30%)     |
|FIRST INCIDENCE (DAYS) |      ---             736 (T)         ---           |      715             685             583           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.719         P=0.481           (e)          |     P=0.244N        P=0.431         P=0.262N       |
|INCIDENTAL TUMOR       |     P=0.719         P=0.481           (e)          |     P=0.134N        P=0.486N        P=0.135N       |
|LOGISTIC REGRESSION    |     P=0.719         P=0.481           (e)          |     P=0.151N        P=0.567         P=0.158N       |
|COCHRAN-ARMITAGE       |     P=0.718N                                       |     P=0.077N                                       |
|FISHER EXACT           |                     P=0.457           (e)          |                     P=0.243N        P=0.095N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/50 (2%)       0/50 (0%)      |     1/50 (2%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |      5.9%            2.6%            0.0%          |      2.2%            3.6%            6.3%          |
|TERMINAL (d)           |     2/34 (6%)       0/36 (0%)       0/33 (0%)      |     0/40 (0%)       1/28 (4%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      736 (T)         676             ---           |      647             735 (T)         735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.149N        P=0.495N        P=0.245N       |     P=0.314         P=0.704         P=0.426        |
|INCIDENTAL TUMOR       |     P=0.171N        P=0.624N        P=0.245N       |     P=0.333         P=0.723N        P=0.469        |
|LOGISTIC REGRESSION    |     P=0.150N        P=0.517N        P=0.245N       |     P=0.347         P=0.765N        P=0.482        |
|COCHRAN-ARMITAGE       |     P=0.142N                                       |     P=0.378                                        |
|FISHER EXACT           |                     P=0.500N        P=0.247N       |                     P=0.753N        P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE  10
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/50 (2%)       0/50 (0%)      |     0/50 (0%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |      5.9%            2.6%            0.0%          |      0.0%            3.6%            6.3%          |
|TERMINAL (d)           |     2/34 (6%)       0/36 (0%)       0/33 (0%)      |     0/40 (0%)       1/28 (4%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      736 (T)         676             ---           |      ---             735 (T)         735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.149N        P=0.495N        P=0.245N       |     P=0.115         P=0.429         P=0.191        |
|INCIDENTAL TUMOR       |     P=0.171N        P=0.624N        P=0.245N       |     P=0.115         P=0.429         P=0.191        |
|LOGISTIC REGRESSION    |     P=0.150N        P=0.517N        P=0.245N       |     P=0.115         P=0.429         P=0.191        |
|COCHRAN-ARMITAGE       |     P=0.142N                                       |     P=0.142                                        |
|FISHER EXACT           |                     P=0.500N        P=0.247N       |                     P=0.500         P=0.247        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       1/45 (2%)       1/48 (2%)      |     0/49 (0%)       0/46 (0%)       2/49 (4%)      |
|ADJUSTED (b)           |      0.0%            2.8%            3.0%          |      0.0%            0.0%            6.3%          |
|TERMINAL (d)           |     0/34 (0%)       1/36 (3%)       1/33 (3%)      |     0/40 (0%)       0/27 (0%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      ---             736 (T)         736 (T)       |      ---             ---             735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.324         P=0.511         P=0.494        |     P=0.082           (e)           P=0.191        |
|INCIDENTAL TUMOR       |     P=0.324         P=0.511         P=0.494        |     P=0.082           (e)           P=0.191        |
|LOGISTIC REGRESSION    |     P=0.324         P=0.511         P=0.494        |     P=0.082           (e)           P=0.191        |
|COCHRAN-ARMITAGE       |     P=0.325                                        |     P=0.098                                        |
|FISHER EXACT           |                     P=0.474         P=0.490        |                       (e)           P=0.247        |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE  11
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     3/50 (6%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |                                                    |      7.5%            6.9%            6.3%          |
|TERMINAL (d)           |                                                    |     3/40 (8%)       1/28 (4%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      735 (T)         722             735 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.509N        P=0.655N        P=0.602N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.488N        P=0.562N        P=0.602N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.508N        P=0.632N        P=0.602N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.406N                                       |
|FISHER EXACT           |                                                    |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/50 (2%)       4/50 (8%)      |     0/50 (0%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |      2.9%            2.8%           10.5%          |      0.0%            6.4%            5.2%          |
|TERMINAL (d)           |     1/34 (3%)       1/36 (3%)       2/33 (6%)      |     0/40 (0%)       1/28 (4%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      736 (T)         736 (T)         604           |      ---             685             472           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.096         P=0.749N        P=0.172        |     P=0.147         P=0.177         P=0.211        |
|INCIDENTAL TUMOR       |     P=0.111         P=0.749N        P=0.204        |     P=0.182         P=0.277         P=0.267        |
|LOGISTIC REGRESSION    |     P=0.097         P=0.749N        P=0.178        |     P=0.192         P=0.217         P=0.309        |
|COCHRAN-ARMITAGE       |     P=0.101                                        |     P=0.176                                        |
|FISHER EXACT           |                     P=0.753N        P=0.181        |                     P=0.247         P=0.247        |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE  12
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/50 (2%)       4/50 (8%)      |     0/50 (0%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |      5.9%            2.8%           10.5%          |      0.0%            6.4%            5.2%          |
|TERMINAL (d)           |     2/34 (6%)       1/36 (3%)       2/33 (6%)      |     0/40 (0%)       1/28 (4%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      736 (T)         736 (T)         604           |      ---             685             472           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.228         P=0.480N        P=0.323        |     P=0.147         P=0.177         P=0.211        |
|INCIDENTAL TUMOR       |     P=0.250         P=0.480N        P=0.365        |     P=0.182         P=0.277         P=0.267        |
|LOGISTIC REGRESSION    |     P=0.227         P=0.480N        P=0.329        |     P=0.192         P=0.217         P=0.309        |
|COCHRAN-ARMITAGE       |     P=0.238                                        |     P=0.176                                        |
|FISHER EXACT           |                     P=0.500N        P=0.339        |                     P=0.247         P=0.247        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     1/50 (2%)       0/50 (0%)       3/50 (6%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      2.5%            0.0%            8.0%          |
|TERMINAL (d)           |     0/34 (0%)       0/36 (0%)       0/33 (0%)      |     1/40 (3%)       0/28 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      735 (T)         ---             641           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.144         P=0.571N        P=0.243        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.206         P=0.571N        P=0.410        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.177         P=0.571N        P=0.317        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.176                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500N        P=0.309        |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE  13
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      6/50 (12%)      8/50 (16%)     |    23/50 (46%)     19/50 (38%)     16/50 (32%)     |
|ADJUSTED (b)           |     14.0%           15.1%           20.6%          |     50.9%           52.7%           44.1%          |
|TERMINAL (d)           |     2/34 (6%)       3/36 (8%)       5/33 (15%)     |    18/40 (45%)     12/28 (43%)     12/32 (38%)     |
|FIRST INCIDENCE (DAYS) |      520             559             182           |      473             371             641           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.307         P=0.596         P=0.361        |     P=0.340N        P=0.400         P=0.358N       |
|INCIDENTAL TUMOR       |     P=0.406         P=0.490         P=0.444        |     P=0.146N        P=0.331N        P=0.175N       |
|LOGISTIC REGRESSION    |     P=0.440         P=0.591         P=0.543        |     P=0.146N        P=0.341N        P=0.182N       |
|COCHRAN-ARMITAGE       |     P=0.330                                        |     P=0.091N                                       |
|FISHER EXACT           |                     P=0.620N        P=0.387        |                     P=0.272N        P=0.109N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      6/50 (12%)      8/50 (16%)     |    22/50 (44%)     19/50 (38%)     13/50 (26%)     |
|ADJUSTED (b)           |     14.0%           15.1%           20.6%          |     48.6%           52.7%           39.2%          |
|TERMINAL (d)           |     2/34 (6%)       3/36 (8%)       5/33 (15%)     |    17/40 (43%)     12/28 (43%)     12/32 (38%)     |
|FIRST INCIDENCE (DAYS) |      520             559             182           |      473             371             673           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.307         P=0.596         P=0.361        |     P=0.191N        P=0.342         P=0.189N       |
|INCIDENTAL TUMOR       |     P=0.406         P=0.490         P=0.444        |     P=0.077N        P=0.394N        P=0.104N       |
|LOGISTIC REGRESSION    |     P=0.440         P=0.591         P=0.543        |     P=0.069N        P=0.412N        P=0.091N       |
|COCHRAN-ARMITAGE       |     P=0.330                                        |     P=0.038N*                                      |
|FISHER EXACT           |                     P=0.620N        P=0.387        |                     P=0.342N        P=0.046N*      |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE  14
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    17/50 (34%)     21/50 (42%)     17/50 (34%)     |    29/50 (58%)     24/50 (48%)     24/50 (48%)     |
|ADJUSTED (b)           |     43.7%           51.1%           42.7%          |     67.4%           72.2%           68.4%          |
|TERMINAL (d)           |    13/34 (38%)     16/36 (44%)     11/33 (33%)     |    26/40 (65%)     19/28 (68%)     21/32 (66%)     |
|FIRST INCIDENCE (DAYS) |      514             559             339           |      590             403             646           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.488         P=0.317         P=0.529        |     P=0.462         P=0.277         P=0.518        |
|INCIDENTAL TUMOR       |     P=0.496N        P=0.220         P=0.541N       |     P=0.493N        P=0.584         P=0.524N       |
|LOGISTIC REGRESSION    |     P=0.493         P=0.212         P=0.568        |     P=0.485N        P=0.559N        P=0.518N       |
|COCHRAN-ARMITAGE       |     P=0.541N                                       |     P=0.184N                                       |
|FISHER EXACT           |                     P=0.268         P=0.583N       |                     P=0.212N        P=0.212N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    23/50 (46%)     23/50 (46%)     29/50 (58%)     |    30/50 (60%)     29/50 (58%)     25/50 (50%)     |
|ADJUSTED (b)           |     52.7%           48.3%           64.7%          |     61.2%           67.8%           58.9%          |
|TERMINAL (d)           |    14/34 (41%)     12/36 (33%)     18/33 (55%)     |    21/40 (53%)     15/28 (54%)     15/32 (47%)     |
|FIRST INCIDENCE (DAYS) |      520             470             182           |      423             371             382           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.143         P=0.555N        P=0.160        |     P=0.487         P=0.165         P=0.543        |
|INCIDENTAL TUMOR       |     P=0.183         P=0.525N        P=0.213        |     P=0.138N        P=0.319N        P=0.159N       |
|LOGISTIC REGRESSION    |     P=0.194         P=0.434N        P=0.217        |     P=0.141N        P=0.466N        P=0.194N       |
|COCHRAN-ARMITAGE       |     P=0.136                                        |     P=0.182N                                       |
|FISHER EXACT           |                     P=0.579N        P=0.158        |                     P=0.500N        P=0.211N       |
|=================================================================================================================================|
 
         DATE: 09/13/94                     EXPERIMENT: 05097 TEST: 02                                                 PAGE  15
                          STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALPHA-CHLOROACETOPHENONE
 
                                                 MALE TERMINAL SACRIFICE AT 106 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      CONTROL         2 MG/M3         4 MG/M3       |      CONTROL         2 MG/M3         4 MG/M3       |
|                       |      MALE            MALE            MALE          |      FEMALE          FEMALE          FEMALE        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    33/50 (66%)     35/50 (70%)     39/50 (78%)     |    42/50 (84%)     40/50 (80%)     38/50 (76%)     |
|ADJUSTED (b)           |     72.8%           71.4%           82.7%          |     85.7%           90.6%           88.2%          |
|TERMINAL (d)           |    22/34 (65%)     22/36 (61%)     25/33 (76%)     |    33/40 (83%)     24/28 (86%)     27/32 (84%)     |
|FIRST INCIDENCE (DAYS) |      514             470             182           |      423             371             382           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.140         P=0.474         P=0.153        |     P=0.248         P=0.061         P=0.286        |
|INCIDENTAL TUMOR       |     P=0.150         P=0.564         P=0.165        |     P=0.309N        P=0.497N        P=0.372N       |
|LOGISTIC REGRESSION    |     P=0.148         P=0.517         P=0.171        |     P=0.288N        P=0.484N        P=0.358N       |
|COCHRAN-ARMITAGE       |     P=0.112                                        |     P=0.191N                                       |
|FISHER EXACT           |                     P=0.415         P=0.133        |                     P=0.398N        P=0.227N       |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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