TDMS Study 05097-02 Pathology Tables
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
Facility: Battelle Northwest
Chemical CAS #: 532-27-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3|
| 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | 1 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1|
Cyst | X |
Degeneration, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
Developmental Malformation | X |
Hyperplasia, Squamous | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + I + + + + + + + I + + + + + + + + + I + +|
Degeneration | 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3|
| 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Fibrosis | 2 1 1 2 1 2 2 2 2 1 1 2 2 1 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + I + + + + + + + I + + + + + M + + + I + +|
Degeneration | 3 |
Hyperplasia, Focal | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + I + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + M M + + M + + M M + + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M I + M + + +|
Pars Distalis, Hyperplasia | 2 3 3 3 2 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 2 4 1 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Necrotizing | 3 |
Endometrium, Hyperplasia, Cystic | 1 2 2 3 2 3 2 3 3 2 3 2 3 2 2 3 2 2|
Lumen, Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + M + + + M M M + + M M M M + + M + M + M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Hyperplasia, Lymphoid | 2 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 |
Hyperplasia, Lymphoid | |
Necrosis | 4 |
Capsule, Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3|
| 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + M M + + + + + M + + + + M + M + + +|
Duct, Dilatation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Hair Follicle, Atrophy | 4 4 |
Subcutaneous Tissue, Inflammation, | |
Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hypothalamus, Atrophy | 2 2 3 |
Thalamus, Mineralization | 2 2 |
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Erosion | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Multifocal | 2 2 2 1 2 2 2 2 2 2 2 1 2 1|
Leukocytosis | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 3 |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7|
DAY ON TEST | 4| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 7| 3|
| 7| 5| 5| 5| 3| 5| 0| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 5| 5| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | M + + A + + + + + + A + + + + + + + + + + + + M +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 3 3.3|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | | 2 1.5|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 16 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 1.5|
Cyst | | 1 |
Degeneration, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Developmental Malformation | | 1 |
Hyperplasia, Squamous | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 49 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + I +| 46 |
Degeneration | 2 2 1 2 2 2 2 2 2 1 2 1 2 2 2 2 2 1 1 1 2 2| 41 1.8|
Fibrosis | 1 2 1 1 1 1 2 2 1 2 2 1 1 1 1 1 1 1 2 2| 37 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + I +| 44 |
Degeneration | | 1 3.0|
Hyperplasia, Focal | 1 | 1 1.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M + + M M + + M M + M M M M M M + + + M + M| 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + I + + +| 45 |
Pars Distalis, Hyperplasia | 2 2 1 2 | 11 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 2 1 | 3 1.3|
Follicular Cell, Hyperplasia | 2 1 | 8 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X X X X | 22 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Inflammation, Necrotizing | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 1 2 | 35 2.1|
Lumen, Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sternal, Myelofibrosis | 2 2 2 2 2 2 2 2 2 2 3 | 21 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hyperplasia, Lymphoid | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M M M M + I + + M I + M + M + + + + + + +| 26 |
Hyperplasia, Lymphoid | 2 2| 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M M + + + M + + + M + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage, Acute | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 3| 5 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 | 4 2.8|
Hyperplasia, Lymphoid | 2 2 2 | 3 2.0|
Necrosis | | 1 4.0|
Capsule, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + M + + + M + M M + + + + + + + M + + + + M| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M + + + + + + + M + M + M + + + + + + + +| 39 |
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
Hair Follicle, Atrophy | 3 3 3 | 5 3.4|
Subcutaneous Tissue, Inflammation, | | |
Subacute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hypothalamus, Atrophy | 2 | 4 2.3|
Thalamus, Mineralization | 2 2 2 | 5 2.0|
Ventricle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Erosion | 3 | 1 3.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic, Multifocal | 1 1 2 2 2 2 1 2 2 1 1 2 | 26 1.7|
Leukocytosis | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| |
| 2| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | I + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | A + + A + + + + + + + + + + + + + A + + + + + + +| 47 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | | 2 2.5|
Inflammation, Chronic | 2 2 | 4 2.0|
Nephropathy | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic | 2 1 | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2|
| 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Gallbladder | + + M I + I + + + + + + + + + M A + + M A + M M A|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + A + + + + A + + + A + + A + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + A + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + A + A|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + A + + + A + + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + A + + + A + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + A + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + A + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic, Multifocal | 1 2 |
Inflammation, Suppurative | 4 |
Necrosis | 4 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 2 |
Vein, Thrombosis | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + A + +|
Atrophy | 4 |
Cyst | |
Fibrosis, Focal | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + + + + + A + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + A + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Inflammation, Suppurative | 2 |
Atrium, Thrombosis | |
Myocardium, Fibrosis | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2|
| 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + A + + + + + A + + + A + + + + +|
Subcapsular, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + I + + + + A + + + + + A + + + A + + A + +|
Degeneration | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Fibrosis | 2 1 1 2 2 2 2 2 1 1 2 2|
Focal Cellular Change | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + I + + + A + + + + + A + + + A I + A + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + I + A + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + M M M M M M M M + M M + M + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + M + +|
Pars Distalis, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + A + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 2 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + I M + + + + + + I M + + + + + + + A + +|
Abscess | |
Cyst | X X X X X X X X |
Inflammation, Chronic | 2 2 2 2 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Necrotizing | 2 |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 3 2 2 2 2 2 2 1 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + M + + + + + + + + + + + + + A + +|
Sternal, Myelofibrosis | 3 3 2 2 4 2 2 2 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Abscess | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + M + + + + + + + + + + + + + M + I|
Hemorrhage, Acute | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + M + + M +|
Hemorrhage, Acute | |
Hyperplasia, Lymphoid | 2 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + A + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2|
| 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 3 2 3 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation, Hemosiderin | 2 2|
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + I + + + + M + + I M + A + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + M + M M + + + M + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + M + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic, Focal | 2 |
Hypothalamus, Atrophy | 4|
Thalamus, Atrophy | 4|
Thalamus, Mineralization | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | |
Inflammation, Chronic, Multifocal | 2 2 2 2 2 1 2 2 2 2 |
Inflammation, Multifocal, Suppurative| 3 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3|
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + A + +|
Peritracheal Tissue, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 2| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 8| 1| 6| 3| 3| 9| 4| 2| 3| 3| 8| 8| 3| 3| 3| 2|
| 8| 8| 8| 3| 8| 8| 8| 8| 8| 3| 8| 7| 8| 8| 3| 3| 0| 8| 8| 5| 7| 8| 7| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Amyloid Deposition | 4 |
Cyst, Multiple | X |
Inflammation, Chronic | 2 2 2 2 |
Nephropathy | |
Renal Tubule, Dilatation | 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| |
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| |
| 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + M + + M + + + + + A A + + + A + + +| 33 |
Inflammation, Suppurative | 3| 2 2.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + M + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + A + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Multifocal | 1 | 3 1.3|
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 1 4.0|
Serosa, Inflammation, Suppurative | 2| 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 13 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 3| 2 3.0|
Fat, Necrosis | | 1 2.0|
Vein, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 4 | 2 4.0|
Cyst | X | 1 |
Fibrosis, Focal | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 2| 1 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | 2 2 | 2 2.0|
Duct, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| |
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| |
| 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Inflammation, Suppurative | | 1 2.0|
Atrium, Thrombosis | X X | 2 |
Myocardium, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 |
Subcapsular, Hyperplasia | 2 1 2 1 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 42 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| 44 |
Degeneration | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 39 1.9|
Fibrosis | 1 1 2 2 1 2 1 1 1 2 2| 23 1.6|
Focal Cellular Change | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + I + + + M + + + + + + + + + + + + + M + + +| 38 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + I + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M M M M M + M M + + M M M M M + M + + M M| 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + I + + + M + + + + + + + + M M + + +| 43 |
Pars Distalis, Hyperplasia | 1 2 2 3 3 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + M +| 46 |
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Cyst | X | 2 |
Follicular Cell, Hyperplasia | 1 3 | 6 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M +| 44 |
Abscess | 2| 1 2.0|
Cyst | X 2 X X X X X | 15 2.0|
Inflammation, Chronic | | 5 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Necrotizing | 4 | 2 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2 2 2 2 2 | 35 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Sternal, Myelofibrosis | 1 2 3 3 2 2 2 2 2 | 19 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| |
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| |
| 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + M + + + + + M +| 48 |
Mesenteric, Abscess | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + + M I + + + I + M +| 38 |
Hemorrhage, Acute | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + M + + + + + M + + + + + M M| 41 |
Hemorrhage, Acute | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 | 8 2.4|
Hyperplasia, Lymphoid | 2 2 3 2 | 6 2.2|
Pigmentation, Hemosiderin | | 2 2.0|
Capsule, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + M + M A + + + + + + + + M M + + + + + + +| 37 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + M I + + M M + + + + + M + + + M + + M| 37 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | 3 3 3 4 | 8 2.9|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Focal | | 1 2.0|
Hypothalamus, Atrophy | | 1 4.0|
Thalamus, Atrophy | | 1 4.0|
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 | 12 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + I + + A + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + A + + + + + + + + + + + + + I + + +| 47 |
Inflammation, Chronic | 2 3 | 2 2.5|
Inflammation, Chronic, Multifocal | 2 2 2 1 2 1 2 2 1 | 19 1.8|
Inflammation, Multifocal, Suppurative| | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 5| 5| |
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 5| 8| 3| 3| 3| 6| 3| 9| 4| |
| 8| 8| 3| 8| 8| 8| 8| 5| 8| 8| 8| 1| 7| 8| 8| 8| 6| 0| 9| 8| 8| 5| 8| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Mucosa, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + I +| 46 |
Peritracheal Tissue, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | M | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 4.0|
Cyst, Multiple | | 1 |
Inflammation, Chronic | 1 2 2 2 2 2 1| 11 1.8|
Nephropathy | 3 3 3 | 3 3.0|
Renal Tubule, Dilatation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 | 13 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3|
| 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Gallbladder | + + + M + + + + A M + + + + A + + + + M + + A + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + M + + + + + M + + + + + + + A + +|
Ulcer, Multifocal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + A + + + + + + + A + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + M + + + + + + + A + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytomegaly | |
Inflammation, Chronic, Multifocal | 1 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | |
Vein, Thrombosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Amyloid Deposition, Focal | |
Atrophy | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Dysplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3|
| 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | I + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cyst | |
Degeneration | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Fibrosis | 1 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | I + + + + + + + + + + + + + + I + + + I + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + I + + + + I + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + M + + + M M + M + M M + M M M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + M + I + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 2 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 2 2 3 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + I + + + + + A + + + + + I + + + + + + + + + +|
Abscess | |
Cyst | X X X X X X X |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 2 2 2 4 2 1 2 4 2 2 2 2 2|
Endometrium, Metaplasia, Squamous | 4 |
Lumen, Dilatation | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Hyperplasia | 3 |
Sternal, Myelofibrosis | 2 2 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + M M + + + + + + + + + + + +|
Mediastinal, Inflammation, Chronic | |
Mesenteric, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M M + + + + + M M + + + + M + + + + M + +|
Amyloid Deposition | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3|
| 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + + M + M M + + M M + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Congestion | 2 |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + M + M M + + + + + M + + + + + M + M + +|
Amyloid Deposition | |
Inflammation, Chronic, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + + + + + M + + M + + + M + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
Hair Follicle, Atrophy | 3 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Focal, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute, Multifocal | |
Hyperplasia, Lymphoid | 2 |
Hypothalamus, Atrophy | 2|
Thalamus, Mineralization | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 2 |
Inflammation, Chronic, Multifocal | 2 1 2 2 1 2 2 2 2|
Leukocytosis | 3 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Amyloid Deposition, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Suppurative | 1 2 |
Olfactory Epithelium, Cytoplasmic | |
Alteration | |
Respiratory Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 3| 7| 6| 4| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 9| 8| 3| 6| 1| 4| 3| 3| 4| 3| 3| 3| 3| 3| 3| 5| 3| 3| 7| 3| 3|
| 8| 5| 8| 8| 0| 2| 8| 2| 7| 1| 8| 8| 6| 8| 8| 8| 8| 8| 8| 7| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + A + + + + + A + + + + + + + A + +|
Sclera, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | 2 |
Nephropathy | 2 2 |
Renal Tubule, Crystals | 3 |
Renal Tubule, Cytomegaly | |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| |
| 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + A + M + + A + + + + + A| 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + M + + + + + M + + + + + + + + + A| 42 |
Ulcer, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + M + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + A + + A + + + + + A| 43 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + I + M A + M + + + A| 41 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + A + + A + + + + + A| 43 |
Amyloid Deposition | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + + A + + + + + A| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Cyst | X | 1 |
Cytomegaly | 2 | 1 2.0|
Inflammation, Chronic, Multifocal | | 1 1.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 | 1 1.0|
Vein, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 19 |
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Amyloid Deposition, Focal | 2 | 1 2.0|
Atrophy | 4 2 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + M + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + A| 48 |
Hyperkeratosis | 4 | 1 4.0|
Hyperplasia, Squamous | 3 2 4 | 6 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| |
| 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Amyloid Deposition, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + A| 48 |
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 46 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + M + + + I + + + + + + + + + + + A| 46 |
Amyloid Deposition | 2 | 1 2.0|
Cyst | X X | 2 |
Degeneration | 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 | 37 1.9|
Fibrosis | 2 1 1 1 1 1 2 1 1 2 2 2 2 2 1 2 1 | 36 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | I + + M + + + + M I I + I + + + + + + + + + + + A| 39 |
Amyloid Deposition | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + + + M M M M M M M M M + + + M M M + M| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + I + + + +| 45 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 3 2 2 3 2 | 13 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Inflammation, Chronic | | 1 4.0|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 1 3 4 2 2 | 11 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M A| 45 |
Abscess | 4 | 1 4.0|
Cyst | X X X X X X X | 14 |
Inflammation, Chronic | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Inflammation, Necrotizing | 4 3 | 3 3.7|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 3 1 2 2 2 | 28 2.1|
Endometrium, Metaplasia, Squamous | 4 | 2 4.0|
Lumen, Dilatation | | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| |
| 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Sternal, Hyperplasia | | 1 3.0|
Sternal, Myelofibrosis | 2 1 2 2 2 2 2 2 2 | 18 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + A| 46 |
Mediastinal, Inflammation, Chronic | 4 | 1 4.0|
Mesenteric, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + M + + + + + + M + M + + + + M + M + + A| 36 |
Amyloid Deposition | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + M + + + + + + + + A| 40 |
Hyperplasia, Lymphoid | 4 | 4 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Amyloid Deposition | 2 | 1 2.0|
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 3.0|
Hyperplasia, Lymphoid | | 6 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + M M + M + M M + + M + A| 35 |
Amyloid Deposition | 4 | 1 4.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + M + + + + M + + M + + + + + + + M| 39 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + I + + + + + + + + + + + + + + A| 48 |
Ulcer | | 1 4.0|
Hair Follicle, Atrophy | 3 3 2 3 | 7 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Focal, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute, Multifocal | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hypothalamus, Atrophy | 4 | 2 3.0|
Thalamus, Mineralization | 2 2 2 2 2 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 5| 4| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 3| 8| 7| 0| 2| 3| 3| 2| 3| 3| 3| 3| 3| 1| |
| 8| 8| 8| 8| 8| 8| 1| 8| 0| 8| 8| 8| 3| 2| 5| 7| 8| 8| 4| 8| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Hemorrhage | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 3 2.0|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 1 2 | 18 1.8|
Leukocytosis | | 2 2.5|
Alveolar Epithelium, Hyperplasia | 2 3 2 2 | 4 2.3|
Alveolus, Amyloid Deposition, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Mucosa, Inflammation, Suppurative | 2 | 3 1.7|
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 | 2 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Glands, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + A + A + + + + A + A + + A + + + + + +| 42 |
Sclera, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Amyloid Deposition | 3 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | 1 | 2 1.5|
Nephropathy | 3 3 2 | 5 2.4|
Renal Tubule, Crystals | | 1 3.0|
Renal Tubule, Cytomegaly | 2 | 1 2.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + M M M + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | + |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic, Multifocal | 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion | 4 |
Hyperkeratosis | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic, Focal | |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | 3 |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Tooth | + + + |
Abscess | 2 2 |
Developmental Malformation | X |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 1 1 2 2 1 2 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + I + + + + + + + + I + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + M M M + M M + M + + + M + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + I + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | I + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Abscess | 3 2 4 |
Cyst | X |
Inflammation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Inflammation, Chronic | 4 |
Mesenteric, Autolysis | 4 |
Mesenteric, Hyperplasia, Lymphoid | |
Mesenteric, Inflammation, Chronic | 4 4 |
Mesenteric, Inflammation, Suppurative| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + M + M + M M M + + M + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + M + M + + M + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Infiltration Cellular, Histiocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + M M M M + M + + M M M M + + M M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | 3 |
Prepuce, Ulcer | 3 2 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Coccygeal, Inflammation, Multifocal, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Acute | |
Inflammation, Chronic, Multifocal | 1 2 2 2 1 1 2 2 1 1 2|
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Bronchiole, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Glands, Inflammation, Focal, | |
Suppurative | 2 |
Mucosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + A + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infiltration Cellular, Lymphocyte | 2 1 1 2 2 1 1 1 4 1 1 1 2 1 3 1 2 1 1 2|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 6| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 3| 6| 6| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Nephropathy | 2 2 4 2 2 4 |
Pelvis, Dilatation | |
Pelvis, Inflammation, Suppurative | 2 2 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 3 4 4 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| |
| 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M + M + + + M + + + + + + + + M| 41 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + M + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 2 2 | 4 2.0|
Inflammation, Chronic, Multifocal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Erosion | | 1 4.0|
Hyperkeratosis | 2 2 | 3 2.3|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Ulcer, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | | 1 3.0|
Ulcer, Multiple | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 5 |
Abscess | 2 | 3 2.0|
Developmental Malformation | | 1 |
Dysplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| |
| 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | 2 2 2 1 2 2 2 1 | 17 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 1 | 5 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M M + + M + M M + + M M + + + M M + M M M +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I + I + A + + + + + M + + + + + + +| 44 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia, Focal | 1 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + M + + + + + + + + M + + + +| 47 |
__________________________________________________________________________|____________|
Penis | +| 1 |
Inflammation, Suppurative | 4| 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 10 |
Abscess | | 3 3.0|
Cyst | X X | 3 |
Inflammation | 4 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3| 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | | 2 2.5|
Inflammation, Suppurative | 1| 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| |
| 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Inflammation, Chronic | | 1 4.0|
Mesenteric, Autolysis | | 1 4.0|
Mesenteric, Hyperplasia, Lymphoid | 2 3 | 2 2.5|
Mesenteric, Inflammation, Chronic | | 2 4.0|
Mesenteric, Inflammation, Suppurative| 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + M M + + + + M + + M + + M M M +| 35 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + M M + M + +| 41 |
Hyperplasia, Lymphoid | 2 2 2 3 | 6 2.3|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 2 2 2 2| 10 2.4|
Hyperplasia, Lymphoid | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + M M + M + M M M + M + + M + + M| 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M M M M M M M M M M + M M M M M M M M M M M| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | | 1 3.0|
Prepuce, Ulcer | 4 4 4 4| 8 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Coccygeal, Inflammation, Multifocal, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2| 19 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Acute | 3| 1 3.0|
Inflammation, Chronic, Multifocal | 1 2 1 1 1 1 1 2 2 1 | 21 1.4|
Leukocytosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 3 1.7|
Bronchiole, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 9| 3| 3| 1| 3| 3| 7| 3| 7| 3| 1| 3| 3| 3| 3| 1| 2| 3| 3| 3| 0| 3| 3| 2| |
| 6| 7| 6| 6| 7| 6| 6| 4| 6| 3| 6| 4| 6| 6| 6| 0| 4| 0| 6| 6| 6| 5| 6| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 1| 1 1.0|
Glands, Inflammation, Focal, | | |
Suppurative | 1 | 2 1.5|
Mucosa, Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + A + + + + + + + + + A + + + + + A + + + + + + +| 45 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 2 1 1 1 1 1 2 1 1 2 2 1 1 3 1 2 1| 41 1.5|
Inflammation, Suppurative | 4 2 | 2 3.0|
Nephropathy | | 6 2.7|
Pelvis, Dilatation | 3 | 1 3.0|
Pelvis, Inflammation, Suppurative | 2 2| 4 2.0|
Renal Tubule, Hyperplasia, Focal | 2 | 1 2.0|
Renal Tubule, Inflammation, | | |
Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic | 4 4 2 4| 5 3.6|
Inflammation, Suppurative | | 3 3.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|
| 9| 6| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Gallbladder | + A + + + A M + + + + + + + + + + + + + + M + A +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + M + + + A + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + A +|
Inflammation, Chronic, Multifocal | 2 |
Necrosis | 4 4 |
Sinusoid, Ectasia | 2 |
__________________________________________________________________________|
Pancreas | + + + + + M + + + + + + + + + + + + + + + + + M +|
Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + A +|
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Chronic, Multifocal | 2 |
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + + A +|
Congestion | 2 |
Cyst | X |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + A +|
Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | +|
Abscess | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + A +|
Subcapsular, Hyperplasia | 4 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + A +|
Hypertrophy | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M + M M + + M + + M M M + M + + + + A M|
__________________________________________________________________________|
Pituitary Gland | + I + + + A + M + + M + + M + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|
| 9| 6| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + A +|
Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + A + + + + + + + + M M + + + + + + + A M|
__________________________________________________________________________|
Preputial Gland | + + + M +|
Cyst | X X|
Inflammation | 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Prostate | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + + A |
__________________________________________________________________________|
Testes | + + + + + A + + + + + + + + + + + + + + + + + A +|
Atrophy | 3 3 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + A + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Lymph Node | + + + + + A + + + + + + + + + + + + + + + + + A +|
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
Mesenteric, Hyperplasia, Re Cell | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M A M + M + + + + M + + + + + M + + A +|
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + A + + + M + + + + + M + + M + + M + A +|
Hyperplasia, Lymphoid | 3 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + A +|
Ectopic Tissue | X |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 2 1 2 |
__________________________________________________________________________|
Thymus | + M + I + A M + + + + + M + + M + + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + M + + + + + M M M M + M M M M + M + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + A +|
Abscess | 2 |
Atrophy | 4 |
Hyperplasia, Lymphoid | 4 |
Hair Follicle, Atrophy | 2 |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3|
| 9| 6| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 9| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + A + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic, Multifocal | 2 1 1 2 2 2 2 2 1 2 2 2 |
Leukocytosis | 4 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +|
Glands, Cyst | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X|
Infarct | 2 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 2 1 1 1|
Inflammation, Suppurative | 4 |
Nephropathy | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + A +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| |
| 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | I + + + + + + + + A I + + M M + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + A + A M M + A + + + + + M M A A + +| 36 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A A + + A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + M + + A A + + A + + + + + + + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A A + + A + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A A + + M + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A A + + M + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + A A + + M + + + + + + + A + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic, Multifocal | | 1 2.0|
Necrosis | | 2 4.0|
Sinusoid, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + A + + + + + + + A + + +| 45 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + A A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A A + + + + + + + + + + + + + +| 46 |
Congestion | | 1 2.0|
Cyst | | 1 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + A + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + I + + + + + + + A + + + A + + + + + + + + + + +| 45 |
Subcapsular, Hyperplasia | 4 | 5 2.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + I + + + + + + + A + + + A + + + + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| |
| 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + I + + + + + I + A + + + A + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + I + + + + + + + A + + I A + I + + + + I + + + +| 42 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + + A M M M M M + + M M + M M M + +| 24 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + A I I + I + I + + + + + M + I +| 37 |
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A A + + A + + + + + + + + + + +| 45 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + A M + + A + + + + + + + A + + +| 41 |
__________________________________________________________________________|____________|
Preputial Gland | + | 5 |
Cyst | X | 3 |
Inflammation | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + A + + + A + M + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + A + A A + | 15 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 |
Atrophy | 2 2 2| 8 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + A + + + A + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + A + + + M + + + + + + + + + + +| 46 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mesenteric, Hyperplasia, Re Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + A + + + M + + + + + + + M + + +| 38 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + + M M A + M + M + + M + M + M M + M +| 29 |
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Ectopic Tissue | X | 2 |
Hematopoietic Cell Proliferation | 2 2 2 3 | 5 2.2|
Hyperplasia, Lymphoid | | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| |
| 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + M + + + M + + A A M + A + + + + + + + M M + +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + M M + A M M + M M M M M M M M M M + M| 19 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + A + + I + + + + + + + + + + + +| 47 |
Abscess | | 1 2.0|
Atrophy | | 1 4.0|
Hyperplasia, Lymphoid | | 1 4.0|
Hair Follicle, Atrophy | 4 2 4| 4 3.0|
Prepuce, Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 |
Thalamus, Mineralization | 2 2 1 2 2 2 2 2 1 2 2 1| 21 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + I + + + + + + + + + + +| 47 |
Epithelium, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic, Multifocal | 2 2 1 2 2 2 1 | 19 1.7|
Leukocytosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 1 4 2 | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A A + + A + + + + + + + + + + +| 46 |
Glands, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 7 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Cyst | X | 3 |
Infarct | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 2 1 1 2 1 1 1 2 2 1 2 | 38 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 5| 7| 7| 4| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 2| 0| 3| 7| 9| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 5| 1| 3| 3| |
| 0| 9| 1| 9| 9| 9| 0| 8| 9| 0| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 4.0|
Nephropathy | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A A + + A + + + + + + + A + + +| 44 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0|
| 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + M A A + M + M M M + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + A + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M A + + M + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + A + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + M + + + + + A + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + A + A M + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + M + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cytomegaly | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Infarct | 4 |
Inflammation, Chronic, Multifocal | 1 2 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | 3 2 2 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic, Multifocal | 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + M + + + + I +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + I M I +|
Hyperkeratosis | 2 |
Hyperplasia | 2 |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + + + + I +|
Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Abscess | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + A + + + + + +|
Cardiomyopathy, Focal | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | 2 |
Myocardium, Necrosis | 3 |
Valve, Degeneration, Mucoid | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0|
| 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + I +|
Subcapsular, Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + + I +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + I + + + + I + + + + + + + M + I I + I +|
Degeneration, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + + I + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + M M + M + M + M + + M M M M M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + I + + + + I + + + + + + + + + + M + + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Follicular Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + M + + M M + +|
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 3 4 |
Cyst | |
Inflammation | 4 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + M + + + + + + M + + + + I M|
Abscess | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + A + + M + + + + + +|
Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M M + + + + + + + M + + M M + M + + M + + M|
Hyperplasia, Lymphoid | 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Lymphoid | 3 3 2 3 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2|
Hyperplasia, Lymphoid | 3 2 2 |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0|
| 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + M + M M M M + M M + + + M M M + + M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M + M + M + M M M M M M + M M + M M|
Duct, Cyst | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + M + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hair Follicle, Atrophy | 3 4 |
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Hyperplasia, | |
Lymphoid | 2 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + M + + + + + +|
Thalamus, Mineralization | 2 2 2 2 2 |
Ventricle, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + A + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic, Multifocal | 1 2 1 1 1 1 2 |
Inflammation, Suppurative | |
Leukocytosis | 4 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Pigmentation, Diffuse | 2 |
Bronchiole, Hyperplasia | 2 |
Venule, Thrombosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A A + + + + + +|
Glands, Hyperplasia, Focal | |
Mucosa, Inflammation, Suppurative | 3 |
Olfactory Epithelium, Atrophy | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 6| 6| 7| 7| 6| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 3| 8| 3| 3| 8| 2| 3| 3| 6| 3| 3| 0|
| 7| 7| 7| 9| 2| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 5| 3| 7| 7| 1| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
4 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + A + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + M + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1|
Inflammation, Chronic, Multifocal | |
Inflammation, Suppurative | 2 2 |
Nephropathy | 2 2 2 2 2 |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 2 |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| |
| 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | M + A + + I + + M M A + + + + M M + + + + A + + +| 32 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M A + + + + + + + + + + + + + A + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + M + + + + + + + + A + + A + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + + + + +| 44 |
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A + + + + + + + + + + + + A + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cytomegaly | 3 | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Infarct | | 1 4.0|
Inflammation, Chronic, Multifocal | 4 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________|____________|
Pancreas | + M + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 | 6 2.2|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation, Chronic, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Stomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperkeratosis | 2 | 2 2.0|
Hyperplasia | | 1 2.0|
Hyperplasia, Squamous | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Abscess | 3 3 | 2 3.0|
Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy, Focal | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| |
| 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 2.0|
Myocardium, Necrosis | | 1 3.0|
Valve, Degeneration, Mucoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Subcapsular, Hyperplasia | 2 1 | 6 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M M + + + + + + + + + + + + + + I + + + + + + + +| 41 |
Degeneration, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M M M M M + M M M + + M M + M M + M M M M| 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 46 |
Pars Distalis, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia, Focal | 3 2 1 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + M + + + + + A M + + I + + M +| 42 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 8 |
Abscess | 3 | 3 3.3|
Cyst | X X | 2 |
Inflammation | 4 | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + M + + + + + + + + + + + + + + A + + + + + + + +| 43 |
Abscess | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +| 44 |
Dilatation | 3 | 2 3.0|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Atrophy | 3 2 | 4 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + M + + + + M + + + + + + + +| 47 |
Mediastinal, Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| |
| 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Hyperplasia, Lymphoid | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + + + + M + M + + + + M + + M + + + + +| 36 |
Hyperplasia, Lymphoid | | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + M M + M M M + + M + M M + M + + +| 38 |
Hyperplasia, Lymphoid | | 4 2.8|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 5 2.0|
Hyperplasia, Lymphoid | | 3 2.3|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + M + M M M + M A + M + + + + + +| 29 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M + M M + + M + M M M + + M M M M M + + + M| 15 |
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Hyperplasia, Lymphoid | | 1 2.0|
Hair Follicle, Atrophy | | 2 3.5|
Prepuce, Inflammation, Suppurative | 4 | 1 4.0|
Subcutaneous Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Thalamus, Mineralization | 2 2 2 2 | 9 2.0|
Ventricle, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + A + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic, Multifocal | 2 2 2 2 1 1 2 2 1| 16 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05097-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:12:40
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 2| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 1| 6| 3| 3| 3| 3| 5| 3| 3| 3| |
| 7| 9| 3| 8| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
4 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 4 | 1 4.0|
Leukocytosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Pigmentation, Diffuse | | 1 2.0|
Bronchiole, Hyperplasia | | 1 2.0|
Venule, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Glands, Hyperplasia, Focal | 3 | 1 3.0|
Mucosa, Inflammation, Suppurative | 1 | 2 2.0|
Olfactory Epithelium, Atrophy | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + A + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + A + + + + + + + + + + + + + A + + + A + + +| 45 |
__________________________________________________________________________|____________|
Harderian Gland | +| 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 2 1 1 2 2 1 1 1 2 1 2 1 1 1 1 1 1 2 2 1 1 | 42 1.3|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
Nephropathy | 1 2 2 2 2 | 10 1.9|
Pelvis, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + A + + + + + + + +| 47 |
Dilatation | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Lumen, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
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