TDMS Study 05097-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05097 ALPHA-CHLOROACETOPHENONE TIME: 08:21:09
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55107
CONT: N01-ES-38061 CAS: 532-27-4
PATHOLOGIST: R. BUSCH
--------------------------------------------------------------------------------
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05097 ALPHA-CHLOROACETOPHENONE TIME: 08:21:09
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55107
CONT: N01-ES-38061 CAS: 532-27-4
PATHOLOGIST: R. BUSCH
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 514 520 535 588 605 666 673 674 697 713 |
| 714 716 717 723 730 735 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 470 494 516 520 520 539 541 559 599 611 |
| 640 676 708 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 4 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 182 339 429 455 604 605 623 643 661 665 |
| 675 682 685 715 718 723 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 90.0 90.0 68.0 |
| | |
| | |
|2 MG/M3 | 100.0 100.0 100.0 100.0 100.0 98.0 86.0 82.0 78.0 72.0 |
| | |
| | |
|4 MG/M3 | 100.0 100.0 98.0 96.0 96.0 92.0 92.0 88.0 80.0 66.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2 MG/M3 4 MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 72.0% 66.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.807 P=0.982N P=0.869 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 657.5 580.4 596.3 |
|NATURAL DEATHS (C) | (19.7) (22.0) (37.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 710.9 692.4 688.5 |
|(STANDARD ERROR) | ( 8.1) (11.6) (15.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 423 473 522 583 590 647 666 710 715 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 237 371 403 493 543 556 583 590 618 639 |
| 643 648 658 665 667 680 685 687 693 707 |
| 720 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 4 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 350 382 417 472 505 527 557 583 611 618 |
| 638 641 646 662 673 690 695 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 90.0 88.0 80.0 |
| | |
| | |
|2 MG/M3 | 100.0 100.0 98.0 98.0 94.0 94.0 90.0 84.0 72.0 56.0 |
| | |
| | |
|4 MG/M3 | 100.0 100.0 100.0 98.0 94.0 92.0 88.0 84.0 72.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 2 MG/M3 4 MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 56.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.095 P=0.017 P=0.099 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 605.0 600.4 577.3 |
|NATURAL DEATHS (C) | (33.4) (26.7) (26.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 709.0 675.8 678.2 |
|(STANDARD ERROR) | ( 9.8) (15.0) (14.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALPHA-CHLOROACETOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2 MG/M3 = 2
4 MG/M3 = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
|
| 3 3 2 2 1 1
|
96 + 3 3 2 2 1 1
|
| 3 3 2 2 1 1
|
92 + 3 1 1
|
P | 2 2 1 1
E |
R 88 + 22 3 3 11
C |
E | 2 2 3 3
N |
T 84 + 2 2 3 3 1 1
|
S | 2 2 1 1
U |
R 80 + 2 2 3 3
V |
I | 2 23 11
V |
A 76 + 2 2
L |
| 3 211 2
|
72 + 1 12
|
| 33
|
68 + 3 11
|
| 33
|
64 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.
ALPHA-CHLOROACETOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
2 MG/M3 = 2
4 MG/M3 = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 2 3 1
| 2 3 2 3 1 1
P 96 + 2 3 2 3 1 1
E | 2 3 3 2 1 1
R | 3 2 3 2 1 1
C | 3 3 2 2 1 1
E 88 + 3 2 2 1 1
N | 3 2 2 1 1
T | 3 2 32 11
| 32 2
S 80 + 3 3 1 1
U | 22
R | 322
V | 32 2
I 72 + 223
V | 2323
A | 33
L | 223 3
64 + 3 3
| 2 2
| 2 2
| 22
56 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.
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