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TDMS Study 05097-02 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/13/94   
EXP: 05097                ALPHA-CHLOROACETOPHENONE             TIME: 08:21:09   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55107    
CONT: N01-ES-38061                                             CAS: 532-27-4    
PATHOLOGIST: R. BUSCH                                                           
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


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TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/13/94  
EXP: 05097                ALPHA-CHLOROACETOPHENONE             TIME: 08:21:09  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55107   
CONT: N01-ES-38061                                             CAS: 532-27-4   
PATHOLOGIST: R. BUSCH                                                          

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      514   520   535   588   605   666   673   674   697   713                 |
 |      714   716   717   723   730   735                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      470   494   516   520   520   539   541   559   599   611                 |
 |      640   676   708   732                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 4 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      182   339   429   455   604   605   623   643   661   665                 |
 |      675   682   685   715   718   723   733                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  90.0  90.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2 MG/M3    |   100.0 100.0 100.0 100.0 100.0  98.0  86.0  82.0  78.0  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 |4 MG/M3    |   100.0 100.0  98.0  96.0  96.0  92.0  92.0  88.0  80.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          2 MG/M3          4 MG/M3       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.0%            72.0%            66.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.807          P=0.982N         P=0.869       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       657.5            580.4            596.3         |
 |NATURAL DEATHS (C)      |       (19.7)           (22.0)           (37.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       710.9            692.4            688.5         |
 |(STANDARD ERROR)        |       ( 8.1)           (11.6)           (15.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      423   473   522   583   590   647   666   710   715   721                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      237   371   403   493   543   556   583   590   618   639                 |
 |      643   648   658   665   667   680   685   687   693   707                 |
 |      720   722                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 4 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      350   382   417   472   505   527   557   583   611   618                 |
 |      638   641   646   662   673   690   695   724                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  98.0  96.0  94.0  90.0  88.0  80.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2 MG/M3    |   100.0 100.0  98.0  98.0  94.0  94.0  90.0  84.0  72.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |4 MG/M3    |   100.0 100.0 100.0  98.0  94.0  92.0  88.0  84.0  72.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          2 MG/M3          4 MG/M3       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       80.0%            56.0%            64.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.095          P=0.017          P=0.099       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       605.0            600.4            577.3         |
 |NATURAL DEATHS (C)      |       (33.4)           (26.7)           (26.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       709.0            675.8            678.2         |
 |(STANDARD ERROR)        |       ( 9.8)           (15.0)           (14.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                      ALPHA-CHLOROACETOPHENONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2 MG/M3          = 2
                                                        4 MG/M3          = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                            3                                             2     1
      |
      |                              3                        3                    2  2  1 1
      |
   96 +                                                       3             3         2  2 1 1
      |
      |                                                                     3   3        2 2 1      1
      |
   92 +                                                                         3                   1   1
      |
P     |                                                                                    2 2          1         1
E     |
R  88 +                                                                                      22         3 3       11
C     |
E     |                                                                                       2 2         3  3
N     |
T  84 +                                                                                         2      2     3   3 1  1
      |
S     |                                                                                                2 2            1 1
U     |
R  80 +                                                                                                  2   2   3 3
V     |
I     |                                                                                                      2     23   11
V     |
A  76 +                                                                                                            2    2
L     |
      |                                                                                                             3   211 2
      |
   72 +                                                                                                                   1 12
      |
      |                                                                                                                  33
      |
   68 +                                                                                                                   3 11
      |
      |                                                                                                                     33
      |
   64 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 7 obs hidden.

                                                      ALPHA-CHLOROACETOPHENONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2 MG/M3          = 2
                                                        4 MG/M3          = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1                                    2                 3           1
      |                                      2                 3  2  3     1       1
P  96 +                                                           2  3  2 3        1       1
E     |                                                                 2 3        3  2    1        1
R     |                                                                            3  2 3     2     1 1
C     |                                                                                 3   3 2 2     1       1
E  88 +                                                                                     3   2   2         1   1
N     |                                                                                         3   2 2           1     1
T     |                                                                                             3 2  32             11
      |                                                                                                  32  2
S  80 +                                                                                                   3  3           1  1
U     |                                                                                                      22
R     |                                                                                                      322
V     |                                                                                                       32 2
I  72 +                                                                                                          223
V     |                                                                                                           2323
A     |                                                                                                              33
L     |                                                                                                             223   3
   64 +                                                                                                                   3 3
      |                                                                                                              2 2
      |                                                                                                                2 2
      |                                                                                                                  22
   56 +                                                                                                                   2 2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.

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