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TDMS Study 05097-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                      ALPHA-CHLOROACETOPHENONE


NTP Experiment-Test: 05097-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59




       Facility:  Battelle Northwest

       Chemical CAS #:  532-27-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          22           28           22                                                  
    Dead                                               5            2            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           20           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (49)         (29)         (48)                                                
      Anus, Parasite Metazoan                          1 (2%)                                                                       
   Intestine Large, Cecum                             (47)         (28)         (41)                                                
      Inflammation                                                               1 (2%)                                             
      Parasite Metazoan                                3 (6%)       1 (4%)       4 (10%)                                            
      Ulcer                                                                      1 (2%)                                             
   Intestine Large, Colon                             (48)         (28)         (48)                                                
      Parasite Metazoan                                2 (4%)       3 (11%)      4 (8%)                                             
   Intestine Large, Rectum                            (44)         (28)         (43)                                                
      Parasite Metazoan                                2 (5%)                    4 (9%)                                             
   Intestine Small, Ileum                             (46)         (27)         (45)                                                
      Hyperplasia, Lymphoid                            4 (9%)       2 (7%)       6 (13%)                                            
      Parasite Metazoan                                             1 (4%)                                                          
   Liver                                              (49)         (41)         (49)                                                
      Angiectasis                                                   4 (10%)      3 (6%)                                             
      Basophilic Focus                                31 (63%)     25 (61%)     33 (67%)                                            
      Clear Cell Focus                                 1 (2%)                                                                       
      Degeneration, Fatty                             13 (27%)     13 (32%)     10 (20%)                                            
      Eosinophilic Focus                                            2 (5%)                                                          
      Hematopoietic Cell Proliferation                 7 (14%)      2 (5%)       5 (10%)                                            
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       5 (10%)      6 (15%)      4 (8%)                                             
      Inflammation, Focal, Granulomatous              26 (53%)     25 (61%)     26 (53%)                                            
      Leukocytosis                                     1 (2%)                    3 (6%)                                             
      Necrosis                                         7 (14%)      2 (5%)       7 (14%)                                            
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Bile Duct, Hyperplasia                          17 (35%)      8 (20%)     13 (27%)                                            
      Hepatocyte, Hyperplasia                          1 (2%)       1 (2%)       2 (4%)                                             
      Hepatocyte, Hyperplasia, Focal                                2 (5%)                                                          
   Mesentery                                          (6)          (2)          (2)                                                 
      Hemorrhage                                       1 (17%)                                                                      
      Inflammation, Granulomatous, Multifocal,                                                                                      
           Suppurative                                 1 (17%)                                                                      
      Fat, Inflammation, Chronic                       2 (33%)      1 (50%)      1 (50%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    1 (17%)      1 (50%)      1 (50%)                                            
   Pancreas                                           (49)         (30)         (47)                                                
      Inflammation                                     4 (8%)                    2 (4%)                                             
      Acinus, Atrophy                                 15 (31%)      6 (20%)     14 (30%)                                            
      Acinus, Cytomegaly                               2 (4%)       1 (3%)       1 (2%)                                             
   Pharynx                                            (1)                                                                           
      Palate, Inflammation, Chronic                    1 (100%)                                                                     
   Salivary Glands                                    (49)         (29)         (49)                                                
      Inflammation, Suppurative                                     1 (3%)       4 (8%)                                             
      Duct, Hyperplasia                               14 (29%)      8 (28%)     19 (39%)                                            
   Stomach, Forestomach                               (47)         (49)         (49)                                                
      Hyperplasia, Squamous                            2 (4%)       6 (12%)      8 (16%)                                            
      Inflammation                                     1 (2%)       7 (14%)      8 (16%)                                            
      Ulcer                                            1 (2%)       4 (8%)       5 (10%)                                            
   Stomach, Glandular                                 (49)         (50)         (49)                                                
      Erosion                                                                    1 (2%)                                             
      Inflammation                                     1 (2%)       1 (2%)       2 (4%)                                             
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                         1 (2%)                                                          
   Tooth                                              (1)          (1)          (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
      Inflammation, Chronic, Suppurative               1 (100%)                                                                     
      Inflammation, Suppurative                                     1 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (2)                                                 
      Inflammation                                                               2 (100%)                                           
   Heart                                              (49)         (30)         (50)                                                
      Inflammation, Chronic                           38 (78%)     16 (53%)     37 (74%)                                            
      Atrium, Thrombosis                               1 (2%)       1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (48)                                                
      Degeneration                                                  2 (4%)       1 (2%)                                             
      Degeneration, Cystic                                                       1 (2%)                                             
      Degeneration, Fatty                             22 (45%)     29 (58%)     28 (58%)                                            
      Focal Cellular Change                            8 (16%)      5 (10%)      3 (6%)                                             
      Hematopoietic Cell Proliferation                 5 (10%)      7 (14%)     10 (21%)                                            
      Hyperplasia                                     10 (20%)      2 (4%)      11 (23%)                                            
      Hypertrophy                                                   1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Bilateral, Hypertrophy                                        1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Gland, Medulla                             (49)         (50)         (48)                                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hyperplasia                                     15 (31%)     10 (20%)     11 (23%)                                            
   Parathyroid Gland                                  (32)         (22)         (38)                                                
      Hyperplasia                                                   1 (5%)       2 (5%)                                             
   Pituitary Gland                                    (49)         (48)         (49)                                                
      Cyst                                             1 (2%)                                                                       
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Degeneration, Cystic              3 (6%)                    2 (4%)                                             
      Pars Distalis, Hyperplasia                      13 (27%)      5 (10%)      7 (14%)                                            
      Pars Distalis, Hyperplasia, Focal                             1 (2%)                                                          
      Pars Distalis, Infiltration Cellular, Mixed                                                                                   
          Cell                                         1 (2%)                                                                       
      Pars Distalis, Mineralization                                 1 (2%)                                                          
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (47)         (30)         (45)                                                
      Cyst                                             1 (2%)                                                                       
      C-Cell, Hyperplasia                             24 (51%)     14 (47%)     21 (47%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (33)         (42)                                                
      Cyst                                             2 (4%)                                                                       
      Hyperplasia                                      2 (4%)       3 (9%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                        6 (13%)     10 (30%)      7 (17%)                                            
      Duct, Hyperplasia                                2 (4%)                                                                       
      Duct, Inflammation, Suppurative                  1 (2%)                                                                       
   Ovary                                              (49)         (31)         (49)                                                
      Atrophy                                          8 (16%)      3 (10%)      6 (12%)                                            
      Cyst                                             6 (12%)      4 (13%)      1 (2%)                                             
      Infiltration Cellular, Mixed Cell                                          1 (2%)                                             
      Interstitium, Hyperplasia                        1 (2%)                                                                       
   Oviduct                                                                      (1)                                                 
      Cyst                                                                       1 (100%)                                           
   Uterus                                             (49)         (33)         (48)                                                
      Dilatation                                                    1 (3%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Prolapse                                                      1 (3%)                                                          
      Endometrium, Cyst                                                          1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Endometrium, Cyst, Multiple                      1 (2%)       1 (3%)                                                          
      Endometrium, Inflammation, Suppurative                                     1 (2%)                                             
   Vagina                                                          (1)                                                              
      Hypertrophy                                                   1 (100%)                                                        
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (30)         (47)                                                
      Depletion Cellular                               1 (2%)                                                                       
      Myelofibrosis                                    2 (4%)                    2 (4%)                                             
   Lymph Node                                         (49)         (31)         (49)                                                
      Axillary, Hematopoietic Cell Proliferation       1 (2%)                                                                       
      Mesenteric, Inflammation, Granulomatous                                    1 (2%)                                             
      Pancreatic, Inflammation, Granulomatous                       1 (3%)                                                          
   Lymph Node, Bronchial                              (44)         (26)         (41)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                      1 (2%)                    2 (5%)                                             
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                                             
   Lymph Node, Mandibular                             (46)         (30)         (47)                                                
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hyperplasia                                     15 (33%)      8 (27%)     17 (36%)                                            
   Spleen                                             (49)         (35)         (49)                                                
      Fibrosis                                         2 (4%)       1 (3%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 5 (10%)      1 (3%)       3 (6%)                                             
      Hyperplasia, Lymphoid                                         1 (3%)       1 (2%)                                             
      Inflammation, Focal, Granulomatous                            1 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)                                                
      Galactocele                                     10 (21%)      8 (16%)      3 (6%)                                             
      Hyperplasia                                      6 (13%)      9 (18%)     11 (22%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
   Skin                                               (49)         (27)         (47)                                                
      Acanthosis                                       1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)       1 (4%)       2 (4%)                                             
      Subcutaneous Tissue, Inflammation, Chronic       2 (4%)       1 (4%)                                                          
      Subcutaneous Tissue, Necrosis                                 1 (4%)                                                          
      Subcutaneous Tissue, Thrombosis                               1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (30)         (50)                                                
      Fibrous Osteodystrophy                                        1 (3%)                                                          
      Fracture                                         1 (2%)                                                                       
      Inflammation, Chronic, Suppurative               1 (2%)                                                                       
      Osteopetrosis                                    3 (6%)       4 (13%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (30)         (50)                                                
      Compression                                                                1 (2%)                                             
      Hemorrhage                                       1 (2%)       2 (7%)       2 (4%)                                             
      Hydrocephalus                                                 1 (3%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (48)         (27)         (49)                                                
      Hyperplasia                                                   1 (4%)       2 (4%)                                             
      Inflammation                                     2 (4%)                                                                       
      Inflammation, Suppurative                       18 (38%)      1 (4%)      22 (45%)                                            
      Metaplasia, Squamous                             1 (2%)                    2 (4%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Lung                                               (49)         (40)         (49)                                                
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       4 (8%)       7 (18%)      1 (2%)                                             
      Infiltration Cellular, Mixed Cell                1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Inflammation, Chronic, Focal                     5 (10%)      9 (23%)      9 (18%)                                            
      Metaplasia, Squamous                                                       1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                    2 (4%)                                             
      Thrombosis                                                    1 (3%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)       4 (10%)      6 (12%)                                            
      Alveolus, Infiltration Cellular, Histiocyte     11 (22%)      6 (15%)     11 (22%)                                            
      Bronchiole, Epithelium, Hyperplasia                                        1 (2%)                                             
      Bronchus, Mineralization                                                   1 (2%)                                             
      Bronchus, Epithelium, Hyperplasia                                          1 (2%)                                             
      Mediastinum, Inflammation, Granulomatous                      1 (3%)                                                          
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                            14 (29%)     10 (25%)     14 (29%)                                            
      Pleura, Hyperplasia                                                        1 (2%)                                             
   Nose                                               (48)         (50)         (49)                                                
      Foreign Body                                     3 (6%)       1 (2%)       1 (2%)                                             
      Inflammation                                    41 (85%)     41 (82%)     42 (86%)                                            
      Inflammation, Suppurative                       29 (60%)     27 (54%)     33 (67%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Thrombosis                                       7 (15%)      2 (4%)       3 (6%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     7 (15%)     11 (22%)      7 (14%)                                            
      Olfactory Epithelium, Degeneration               2 (4%)                    1 (2%)                                             
      Olfactory Epithelium, Metaplasia                 4 (8%)       3 (6%)       3 (6%)                                             
      Respiratory Epithelium, Hyperplasia             20 (42%)     31 (62%)     38 (78%)                                            
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       7 (14%)     26 (53%)                                            
      Respiratory Epithelium, Ulcer                                 1 (2%)                                                          
      Vomeronasal Organ, Inflammation                               2 (4%)                                                          
      Vomeronasal Organ, Inflammation, Suppurative     6 (13%)      3 (6%)       5 (10%)                                            
   Trachea                                            (48)         (29)         (48)                                                
      Inflammation                                     2 (4%)                                                                       
      Inflammation, Suppurative                        3 (6%)       2 (7%)       4 (8%)                                             
      Epithelium, Hyperplasia                          2 (4%)       1 (3%)                                                          
      Epithelium, Metaplasia, Squamous                 3 (6%)       2 (7%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (2)          (48)                                                
      Synechia                                         1 (2%)       1 (50%)      3 (6%)                                             
      Cornea, Inflammation, Suppurative                1 (2%)                                                                       
      Lens, Degeneration                               3 (6%)       1 (50%)      8 (17%)                                            
      Lens, Mineralization                             1 (2%)       1 (50%)      4 (8%)                                             
      Retina, Atrophy                                  6 (12%)      1 (50%)      9 (19%)                                            
   Harderian Gland                                    (5)          (2)          (8)                                                 
      Inflammation                                     1 (20%)                                                                      
      Inflammation, Suppurative                        2 (40%)      2 (100%)     6 (75%)                                            
      Metaplasia, Squamous                             2 (40%)                   3 (38%)                                            
   Lacrimal Gland                                     (3)          (3)          (1)                                                 
      Acinus, Atrophy                                  3 (100%)     3 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (37)         (49)                                                
      Cyst                                             1 (2%)       1 (3%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hydronephrosis                                                             2 (4%)                                             
      Nephropathy                                     48 (98%)     37 (100%)    48 (98%)                                            
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Hyperplasia                                     1 (3%)       1 (2%)                                             
   Urinary Bladder                                    (48)         (31)         (48)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          26           22           24                                                  
    Dead                                              10            6            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           22           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (45)         (48)         (50)                                                
      Anus, Parasite Metazoan                                                    1 (2%)                                             
   Intestine Large, Cecum                             (40)         (44)         (39)                                                
      Parasite Metazoan                                2 (5%)       3 (7%)       3 (8%)                                             
   Intestine Large, Colon                             (44)         (47)         (46)                                                
      Diverticulum                                                               1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation                                                               1 (2%)                                             
      Parasite Metazoan                               10 (23%)      4 (9%)       4 (9%)                                             
   Intestine Large, Rectum                            (40)         (42)         (47)                                                
      Parasite Metazoan                                             2 (5%)       1 (2%)                                             
   Intestine Small, Ileum                             (41)         (45)         (43)                                                
      Hyperplasia, Lymphoid                                         7 (16%)                                                         
      Parasite Metazoan                                             2 (4%)                                                          
   Liver                                              (49)         (50)         (50)                                                
      Angiectasis                                      4 (8%)       7 (14%)      5 (10%)                                            
      Basophilic Focus                                22 (45%)     18 (36%)     21 (42%)                                            
      Clear Cell Focus                                 1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Degeneration                                                               1 (2%)                                             
      Degeneration, Cystic                             2 (4%)       7 (14%)      8 (16%)                                            
      Degeneration, Fatty                              6 (12%)      3 (6%)       8 (16%)                                            
      Eosinophilic Focus                               1 (2%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       5 (10%)      3 (6%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       3 (6%)       3 (6%)       4 (8%)                                             
      Inflammation, Focal, Granulomatous              12 (24%)     19 (38%)     16 (32%)                                            
      Leukocytosis                                                  1 (2%)       1 (2%)                                             
      Necrosis                                         8 (16%)      8 (16%)      5 (10%)                                            
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Bile Duct, Hyperplasia                          32 (65%)     32 (64%)     29 (58%)                                            
      Hepatocyte, Hyperplasia                          4 (8%)                    1 (2%)                                             
      Hepatocyte, Hyperplasia, Focal                   1 (2%)       1 (2%)                                                          
      Hepatocyte, Necrosis                             3 (6%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (2)          (3)          (3)                                                 
      Fat, Inflammation, Chronic                       2 (100%)     2 (67%)      3 (100%)                                           
      Fat, Necrosis                                    2 (100%)     1 (33%)      2 (67%)                                            
   Pancreas                                           (47)         (50)         (49)                                                
      Inflammation                                                               3 (6%)                                             
      Acinus, Atrophy                                 18 (38%)     15 (30%)     25 (51%)                                            
      Acinus, Cytomegaly                               2 (4%)                                                                       
   Salivary Glands                                    (46)         (49)         (49)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation                                     4 (9%)       6 (12%)      6 (12%)                                            
      Necrosis                                                                   1 (2%)                                             
      Duct, Hyperplasia                               11 (24%)     16 (33%)     13 (27%)                                            
      Duct, Inflammation, Suppurative                                            1 (2%)                                             
      Duct, Metaplasia, Squamous                                                 1 (2%)                                             
      Parotid Gland, Atrophy                                                     1 (2%)                                             
   Stomach, Forestomach                               (46)         (49)         (49)                                                
      Hyperplasia, Squamous                            6 (13%)      4 (8%)       7 (14%)                                            
      Inflammation                                     4 (9%)       3 (6%)       6 (12%)                                            
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            4 (9%)       2 (4%)       3 (6%)                                             
   Stomach, Glandular                                 (48)         (49)         (49)                                                
      Ectopic Tissue                                   1 (2%)       1 (2%)                                                          
      Erosion                                                       1 (2%)       1 (2%)                                             
      Inflammation                                     4 (8%)       5 (10%)      1 (2%)                                             
      Mineralization                                   2 (4%)                    3 (6%)                                             
      Ulcer                                            3 (6%)       2 (4%)                                                          
   Tooth                                                                        (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (4)                                                 
      Inflammation                                                               2 (50%)                                            
      Mineralization                                                             2 (50%)                                            
   Heart                                              (49)         (50)         (50)                                                
      Inflammation, Chronic                           47 (96%)     44 (88%)     41 (82%)                                            
      Mineralization                                   1 (2%)                    3 (6%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Atrium, Thrombosis                               5 (10%)      2 (4%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (47)         (49)         (50)                                                
      Degeneration, Fatty                             19 (40%)     30 (61%)     18 (36%)                                            
      Focal Cellular Change                            3 (6%)       3 (6%)       3 (6%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       3 (6%)       3 (6%)                                             
      Hyperplasia                                      6 (13%)      2 (4%)       3 (6%)                                             
      Hypertrophy                                      1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
   Adrenal Gland, Medulla                             (46)         (49)         (50)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                     20 (43%)     15 (31%)     14 (28%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
   Islets, Pancreatic                                 (47)         (50)         (48)                                                
      Cytomegaly                                                                 1 (2%)                                             
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (35)         (33)         (44)                                                
      Hyperplasia                                      4 (11%)                   4 (9%)                                             
   Pituitary Gland                                    (47)         (50)         (48)                                                
      Pars Distalis, Angiectasis                                                 1 (2%)                                             
      Pars Distalis, Cyst                                           1 (2%)       1 (2%)                                             
      Pars Distalis, Hemorrhage                                                  1 (2%)                                             
      Pars Distalis, Hyperplasia                       7 (15%)     10 (20%)      6 (13%)                                            
      Pars Intermedia, Degeneration, Cystic                                      1 (2%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (45)         (46)         (48)                                                
      C-Cell, Hyperplasia                             11 (24%)      5 (11%)     10 (21%)                                            
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (40)         (36)         (39)                                                
      Granuloma Sperm                                  1 (3%)                                                                       
      Inflammation, Chronic                                                      1 (3%)                                             
      Mineralization                                                             1 (3%)                                             
      Necrosis                                                                   1 (3%)                                             
      Vacuolization Cytoplasmic                        8 (20%)                   4 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Serosa, Hyperplasia                                                        1 (3%)                                             
   Preputial Gland                                    (45)         (48)         (50)                                                
      Cyst                                             1 (2%)       2 (4%)                                                          
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                       17 (38%)     15 (31%)     23 (46%)                                            
      Duct, Ectasia                                                              1 (2%)                                             
      Duct, Hyperplasia                                             1 (2%)                                                          
   Prostate                                           (49)         (49)         (47)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                       18 (37%)     23 (47%)     15 (32%)                                            
      Epithelium, Hyperplasia                          7 (14%)      3 (6%)       9 (19%)                                            
   Seminal Vesicle                                    (3)          (3)          (2)                                                 
      Hemorrhage                                       1 (33%)                                                                      
      Inflammation, Suppurative                        2 (67%)      3 (100%)     2 (100%)                                           
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                          8 (16%)     11 (22%)     14 (28%)                                            
      Mineralization                                                             1 (2%)                                             
      Interstitial Cell, Hyperplasia                  13 (26%)      9 (18%)     12 (24%)                                            
      Perivascular, Inflammation                       5 (10%)      3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (46)         (49)         (50)                                                
      Depletion Cellular                                                         1 (2%)                                             
      Myelofibrosis                                    2 (4%)       3 (6%)                                                          
   Lymph Node                                         (48)         (50)         (49)                                                
      Mesenteric, Angiectasis                          1 (2%)                                                                       
      Renal, Hyperplasia                                                         1 (2%)                                             
   Lymph Node, Bronchial                              (44)         (48)         (46)                                                
      Angiectasis                                                                2 (4%)                                             
      Congestion                                       1 (2%)       1 (2%)                                                          
      Hyperplasia                                      2 (5%)                    1 (2%)                                             
      Inflammation, Granulomatous                                   1 (2%)       2 (4%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Lymph Node, Mandibular                             (45)         (43)         (45)                                                
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                     16 (36%)     16 (37%)     15 (33%)                                            
      Inflammation, Granulomatous                                   1 (2%)       1 (2%)                                             
   Spleen                                             (48)         (49)         (49)                                                
      Developmental Malformation                                                 1 (2%)                                             
      Ectopic Tissue                                                1 (2%)                                                          
      Fibrosis                                         6 (13%)      8 (16%)      8 (16%)                                            
      Hematopoietic Cell Proliferation                              3 (6%)       3 (6%)                                             
      Hemorrhage                                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                                      2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (23)         (20)         (23)                                                
      Galactocele                                      7 (30%)      4 (20%)     10 (43%)                                            
      Hyperplasia                                     10 (43%)      8 (40%)      8 (35%)                                            
   Skin                                               (46)         (49)         (47)                                                
      Acanthosis                                                    2 (4%)                                                          
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Prepuce, Inflammation, Suppurative               1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       5 (11%)      1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                               1 (2%)                                                          
      Subcutaneous Tissue, Necrosis                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (47)         (50)         (50)                                                
      Fibrous Osteodystrophy                           1 (2%)                    3 (6%)                                             
      Hyperostosis                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
      Compression                                                   2 (4%)                                                          
      Hemorrhage                                       1 (2%)       7 (14%)      2 (4%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
   Spinal Cord                                        (1)                                                                           
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (48)         (48)         (49)                                                
      Inflammation, Suppurative                       15 (31%)     14 (29%)     21 (43%)                                            
      Metaplasia, Squamous                                          2 (4%)       3 (6%)                                             
   Lung                                               (49)         (50)         (50)                                                
      Congestion                                                    3 (6%)       4 (8%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage                                       2 (4%)       5 (10%)      7 (14%)                                            
      Infiltration Cellular, Mixed Cell                             1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic, Diffuse                   1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                    13 (27%)     13 (26%)      5 (10%)                                            
      Inflammation, Focal, Granulomatous                                         2 (4%)                                             
      Leukocytosis                                                  2 (4%)       2 (4%)                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                   2 (4%)                    2 (4%)                                             
      Pigmentation, Hemosiderin                        3 (6%)                    2 (4%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 5 (10%)      5 (10%)      6 (12%)                                            
      Alveolus, Infiltration Cellular, Histiocyte     11 (22%)      7 (14%)      8 (16%)                                            
      Alveolus, Inflammation, Suppurative                                        1 (2%)                                             
      Artery, Intima, Inflammation, Chronic                                      1 (2%)                                             
      Bronchiole, Inflammation, Suppurative                         1 (2%)       1 (2%)                                             
      Bronchiole, Epithelium, Hyperplasia              1 (2%)       1 (2%)       2 (4%)                                             
      Bronchus, Inflammation, Suppurative                                        2 (4%)                                             
      Bronchus, Epithelium, Hyperplasia                                          1 (2%)                                             
      Bronchus, Epithelium, Metaplasia, Squamous                                 1 (2%)                                             
      Peribronchial, Infiltration Cellular,                                                                                         
          Mononuclear Cell                             1 (2%)                                                                       
      Peribronchiolar, Infiltration Cellular,                                                                                       
          Mononuclear Cell                                                       1 (2%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                             9 (18%)      7 (14%)     13 (26%)                                            
   Nose                                               (46)         (50)         (49)                                                
      Foreign Body                                     3 (7%)       2 (4%)       3 (6%)                                             
      Inflammation                                    30 (65%)     34 (68%)     44 (90%)                                            
      Inflammation, Suppurative                       26 (57%)     36 (72%)     46 (94%)                                            
      Thrombosis                                       7 (15%)      3 (6%)       5 (10%)                                            
      Mucosa, Cyst                                                  1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     9 (20%)      5 (10%)     14 (29%)                                            
      Olfactory Epithelium, Degeneration               4 (9%)                    6 (12%)                                            
      Olfactory Epithelium, Metaplasia                 4 (9%)       2 (4%)       7 (14%)                                            
      Respiratory Epithelium, Hyperplasia             12 (26%)     17 (34%)     44 (90%)                                            
      Respiratory Epithelium, Metaplasia, Squamous     2 (4%)      11 (22%)     27 (55%)                                            
      Vomeronasal Organ, Inflammation, Suppurative     2 (4%)       4 (8%)       6 (12%)                                            
   Trachea                                            (46)         (48)         (49)                                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)       6 (13%)      5 (10%)                                            
      Mineralization                                                             2 (4%)                                             
      Epithelium, Hyperplasia                          1 (2%)       1 (2%)                                                          
      Epithelium, Metaplasia, Squamous                 4 (9%)       6 (13%)      4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05097-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:21:59  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (2)          (50)                                                
      Synechia                                                                   1 (2%)                                             
      Anterior Chamber, Inflammation, Suppurative      2 (4%)                    2 (4%)                                             
      Cornea, Hyperplasia                                                        1 (2%)                                             
      Cornea, Inflammation, Suppurative                2 (4%)                    3 (6%)                                             
      Cornea, Mineralization                                                     3 (6%)                                             
      Lens, Degeneration                               6 (12%)                   7 (14%)                                            
      Lens, Mineralization                                                       2 (4%)                                             
      Retina, Atrophy                                  1 (2%)                    2 (4%)                                             
      Sclera, Inflammation                                                       1 (2%)                                             
   Harderian Gland                                    (1)          (2)                                                              
      Inflammation, Suppurative                                     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hydronephrosis                                                             1 (2%)                                             
      Mineralization                                   2 (4%)                                                                       
      Nephropathy                                     48 (98%)     49 (100%)    48 (96%)                                            
      Pelvis, Inflammation, Suppurative                                          2 (4%)                                             
      Renal Tubule, Hyperplasia                        2 (4%)       3 (6%)       1 (2%)                                             
      Renal Tubule, Inflammation, Suppurative                                    1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (49)                                                
      Calculus Gross Observation                       2 (4%)                                                                       
      Calculus Micro Observation Only                  2 (4%)                                                                       
      Hemorrhage                                       2 (4%)                    1 (2%)                                             
      Inflammation, Suppurative                        3 (6%)       2 (4%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             5 (10%)      3 (6%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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