TDMS Study 05097-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ALPHA-CHLOROACETOPHENONE
NTP Experiment-Test: 05097-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
Facility: Battelle Northwest
Chemical CAS #: 532-27-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 22 28 22
Dead 5 2 4
Survivors
Terminal Sacrifice 23 20 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (49) (29) (48)
Anus, Parasite Metazoan 1 (2%)
Intestine Large, Cecum (47) (28) (41)
Inflammation 1 (2%)
Parasite Metazoan 3 (6%) 1 (4%) 4 (10%)
Ulcer 1 (2%)
Intestine Large, Colon (48) (28) (48)
Parasite Metazoan 2 (4%) 3 (11%) 4 (8%)
Intestine Large, Rectum (44) (28) (43)
Parasite Metazoan 2 (5%) 4 (9%)
Intestine Small, Ileum (46) (27) (45)
Hyperplasia, Lymphoid 4 (9%) 2 (7%) 6 (13%)
Parasite Metazoan 1 (4%)
Liver (49) (41) (49)
Angiectasis 4 (10%) 3 (6%)
Basophilic Focus 31 (63%) 25 (61%) 33 (67%)
Clear Cell Focus 1 (2%)
Degeneration, Fatty 13 (27%) 13 (32%) 10 (20%)
Eosinophilic Focus 2 (5%)
Hematopoietic Cell Proliferation 7 (14%) 2 (5%) 5 (10%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%) 6 (15%) 4 (8%)
Inflammation, Focal, Granulomatous 26 (53%) 25 (61%) 26 (53%)
Leukocytosis 1 (2%) 3 (6%)
Necrosis 7 (14%) 2 (5%) 7 (14%)
Pigmentation, Hemosiderin 1 (2%)
Bile Duct, Hyperplasia 17 (35%) 8 (20%) 13 (27%)
Hepatocyte, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Hepatocyte, Hyperplasia, Focal 2 (5%)
Mesentery (6) (2) (2)
Hemorrhage 1 (17%)
Inflammation, Granulomatous, Multifocal,
Suppurative 1 (17%)
Fat, Inflammation, Chronic 2 (33%) 1 (50%) 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 1 (17%) 1 (50%) 1 (50%)
Pancreas (49) (30) (47)
Inflammation 4 (8%) 2 (4%)
Acinus, Atrophy 15 (31%) 6 (20%) 14 (30%)
Acinus, Cytomegaly 2 (4%) 1 (3%) 1 (2%)
Pharynx (1)
Palate, Inflammation, Chronic 1 (100%)
Salivary Glands (49) (29) (49)
Inflammation, Suppurative 1 (3%) 4 (8%)
Duct, Hyperplasia 14 (29%) 8 (28%) 19 (39%)
Stomach, Forestomach (47) (49) (49)
Hyperplasia, Squamous 2 (4%) 6 (12%) 8 (16%)
Inflammation 1 (2%) 7 (14%) 8 (16%)
Ulcer 1 (2%) 4 (8%) 5 (10%)
Stomach, Glandular (49) (50) (49)
Erosion 1 (2%)
Inflammation 1 (2%) 1 (2%) 2 (4%)
Mineralization 1 (2%)
Ulcer 1 (2%)
Tooth (1) (1) (1)
Inflammation, Chronic 1 (100%)
Inflammation, Chronic, Suppurative 1 (100%)
Inflammation, Suppurative 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Inflammation 2 (100%)
Heart (49) (30) (50)
Inflammation, Chronic 38 (78%) 16 (53%) 37 (74%)
Atrium, Thrombosis 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (48)
Degeneration 2 (4%) 1 (2%)
Degeneration, Cystic 1 (2%)
Degeneration, Fatty 22 (45%) 29 (58%) 28 (58%)
Focal Cellular Change 8 (16%) 5 (10%) 3 (6%)
Hematopoietic Cell Proliferation 5 (10%) 7 (14%) 10 (21%)
Hyperplasia 10 (20%) 2 (4%) 11 (23%)
Hypertrophy 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%) 1 (2%)
Bilateral, Hypertrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Gland, Medulla (49) (50) (48)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 15 (31%) 10 (20%) 11 (23%)
Parathyroid Gland (32) (22) (38)
Hyperplasia 1 (5%) 2 (5%)
Pituitary Gland (49) (48) (49)
Cyst 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Degeneration, Cystic 3 (6%) 2 (4%)
Pars Distalis, Hyperplasia 13 (27%) 5 (10%) 7 (14%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Pars Distalis, Infiltration Cellular, Mixed
Cell 1 (2%)
Pars Distalis, Mineralization 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (47) (30) (45)
Cyst 1 (2%)
C-Cell, Hyperplasia 24 (51%) 14 (47%) 21 (47%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (33) (42)
Cyst 2 (4%)
Hyperplasia 2 (4%) 3 (9%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 6 (13%) 10 (30%) 7 (17%)
Duct, Hyperplasia 2 (4%)
Duct, Inflammation, Suppurative 1 (2%)
Ovary (49) (31) (49)
Atrophy 8 (16%) 3 (10%) 6 (12%)
Cyst 6 (12%) 4 (13%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Interstitium, Hyperplasia 1 (2%)
Oviduct (1)
Cyst 1 (100%)
Uterus (49) (33) (48)
Dilatation 1 (3%)
Inflammation, Suppurative 1 (2%)
Prolapse 1 (3%)
Endometrium, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Endometrium, Cyst, Multiple 1 (2%) 1 (3%)
Endometrium, Inflammation, Suppurative 1 (2%)
Vagina (1)
Hypertrophy 1 (100%)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (30) (47)
Depletion Cellular 1 (2%)
Myelofibrosis 2 (4%) 2 (4%)
Lymph Node (49) (31) (49)
Axillary, Hematopoietic Cell Proliferation 1 (2%)
Mesenteric, Inflammation, Granulomatous 1 (2%)
Pancreatic, Inflammation, Granulomatous 1 (3%)
Lymph Node, Bronchial (44) (26) (41)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%) 2 (5%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Lymph Node, Mandibular (46) (30) (47)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 15 (33%) 8 (27%) 17 (36%)
Spleen (49) (35) (49)
Fibrosis 2 (4%) 1 (3%) 1 (2%)
Hematopoietic Cell Proliferation 5 (10%) 1 (3%) 3 (6%)
Hyperplasia, Lymphoid 1 (3%) 1 (2%)
Inflammation, Focal, Granulomatous 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (50)
Galactocele 10 (21%) 8 (16%) 3 (6%)
Hyperplasia 6 (13%) 9 (18%) 11 (22%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Skin (49) (27) (47)
Acanthosis 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (4%) 2 (4%)
Subcutaneous Tissue, Inflammation, Chronic 2 (4%) 1 (4%)
Subcutaneous Tissue, Necrosis 1 (4%)
Subcutaneous Tissue, Thrombosis 1 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (30) (50)
Fibrous Osteodystrophy 1 (3%)
Fracture 1 (2%)
Inflammation, Chronic, Suppurative 1 (2%)
Osteopetrosis 3 (6%) 4 (13%) 3 (6%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (30) (50)
Compression 1 (2%)
Hemorrhage 1 (2%) 2 (7%) 2 (4%)
Hydrocephalus 1 (3%)
Pigmentation, Hemosiderin 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (27) (49)
Hyperplasia 1 (4%) 2 (4%)
Inflammation 2 (4%)
Inflammation, Suppurative 18 (38%) 1 (4%) 22 (45%)
Metaplasia, Squamous 1 (2%) 2 (4%)
Epithelium, Hyperplasia 1 (2%)
Lung (49) (40) (49)
Congestion 1 (2%)
Hemorrhage 4 (8%) 7 (18%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic, Focal 5 (10%) 9 (23%) 9 (18%)
Metaplasia, Squamous 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 2 (4%)
Thrombosis 1 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%) 4 (10%) 6 (12%)
Alveolus, Infiltration Cellular, Histiocyte 11 (22%) 6 (15%) 11 (22%)
Bronchiole, Epithelium, Hyperplasia 1 (2%)
Bronchus, Mineralization 1 (2%)
Bronchus, Epithelium, Hyperplasia 1 (2%)
Mediastinum, Inflammation, Granulomatous 1 (3%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 14 (29%) 10 (25%) 14 (29%)
Pleura, Hyperplasia 1 (2%)
Nose (48) (50) (49)
Foreign Body 3 (6%) 1 (2%) 1 (2%)
Inflammation 41 (85%) 41 (82%) 42 (86%)
Inflammation, Suppurative 29 (60%) 27 (54%) 33 (67%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Thrombosis 7 (15%) 2 (4%) 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 7 (15%) 11 (22%) 7 (14%)
Olfactory Epithelium, Degeneration 2 (4%) 1 (2%)
Olfactory Epithelium, Metaplasia 4 (8%) 3 (6%) 3 (6%)
Respiratory Epithelium, Hyperplasia 20 (42%) 31 (62%) 38 (78%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 7 (14%) 26 (53%)
Respiratory Epithelium, Ulcer 1 (2%)
Vomeronasal Organ, Inflammation 2 (4%)
Vomeronasal Organ, Inflammation, Suppurative 6 (13%) 3 (6%) 5 (10%)
Trachea (48) (29) (48)
Inflammation 2 (4%)
Inflammation, Suppurative 3 (6%) 2 (7%) 4 (8%)
Epithelium, Hyperplasia 2 (4%) 1 (3%)
Epithelium, Metaplasia, Squamous 3 (6%) 2 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (2) (48)
Synechia 1 (2%) 1 (50%) 3 (6%)
Cornea, Inflammation, Suppurative 1 (2%)
Lens, Degeneration 3 (6%) 1 (50%) 8 (17%)
Lens, Mineralization 1 (2%) 1 (50%) 4 (8%)
Retina, Atrophy 6 (12%) 1 (50%) 9 (19%)
Harderian Gland (5) (2) (8)
Inflammation 1 (20%)
Inflammation, Suppurative 2 (40%) 2 (100%) 6 (75%)
Metaplasia, Squamous 2 (40%) 3 (38%)
Lacrimal Gland (3) (3) (1)
Acinus, Atrophy 3 (100%) 3 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (37) (49)
Cyst 1 (2%) 1 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Hydronephrosis 2 (4%)
Nephropathy 48 (98%) 37 (100%) 48 (98%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Hyperplasia 1 (3%) 1 (2%)
Urinary Bladder (48) (31) (48)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 26 22 24
Dead 10 6 9
Survivors
Terminal Sacrifice 14 22 17
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large (45) (48) (50)
Anus, Parasite Metazoan 1 (2%)
Intestine Large, Cecum (40) (44) (39)
Parasite Metazoan 2 (5%) 3 (7%) 3 (8%)
Intestine Large, Colon (44) (47) (46)
Diverticulum 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation 1 (2%)
Parasite Metazoan 10 (23%) 4 (9%) 4 (9%)
Intestine Large, Rectum (40) (42) (47)
Parasite Metazoan 2 (5%) 1 (2%)
Intestine Small, Ileum (41) (45) (43)
Hyperplasia, Lymphoid 7 (16%)
Parasite Metazoan 2 (4%)
Liver (49) (50) (50)
Angiectasis 4 (8%) 7 (14%) 5 (10%)
Basophilic Focus 22 (45%) 18 (36%) 21 (42%)
Clear Cell Focus 1 (2%)
Congestion 1 (2%)
Degeneration 1 (2%)
Degeneration, Cystic 2 (4%) 7 (14%) 8 (16%)
Degeneration, Fatty 6 (12%) 3 (6%) 8 (16%)
Eosinophilic Focus 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 5 (10%) 3 (6%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 3 (6%) 4 (8%)
Inflammation, Focal, Granulomatous 12 (24%) 19 (38%) 16 (32%)
Leukocytosis 1 (2%) 1 (2%)
Necrosis 8 (16%) 8 (16%) 5 (10%)
Thrombosis 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 32 (65%) 32 (64%) 29 (58%)
Hepatocyte, Hyperplasia 4 (8%) 1 (2%)
Hepatocyte, Hyperplasia, Focal 1 (2%) 1 (2%)
Hepatocyte, Necrosis 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (2) (3) (3)
Fat, Inflammation, Chronic 2 (100%) 2 (67%) 3 (100%)
Fat, Necrosis 2 (100%) 1 (33%) 2 (67%)
Pancreas (47) (50) (49)
Inflammation 3 (6%)
Acinus, Atrophy 18 (38%) 15 (30%) 25 (51%)
Acinus, Cytomegaly 2 (4%)
Salivary Glands (46) (49) (49)
Hemorrhage 1 (2%)
Inflammation 4 (9%) 6 (12%) 6 (12%)
Necrosis 1 (2%)
Duct, Hyperplasia 11 (24%) 16 (33%) 13 (27%)
Duct, Inflammation, Suppurative 1 (2%)
Duct, Metaplasia, Squamous 1 (2%)
Parotid Gland, Atrophy 1 (2%)
Stomach, Forestomach (46) (49) (49)
Hyperplasia, Squamous 6 (13%) 4 (8%) 7 (14%)
Inflammation 4 (9%) 3 (6%) 6 (12%)
Mineralization 1 (2%)
Ulcer 4 (9%) 2 (4%) 3 (6%)
Stomach, Glandular (48) (49) (49)
Ectopic Tissue 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%)
Inflammation 4 (8%) 5 (10%) 1 (2%)
Mineralization 2 (4%) 3 (6%)
Ulcer 3 (6%) 2 (4%)
Tooth (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (4)
Inflammation 2 (50%)
Mineralization 2 (50%)
Heart (49) (50) (50)
Inflammation, Chronic 47 (96%) 44 (88%) 41 (82%)
Mineralization 1 (2%) 3 (6%)
Pigmentation, Hemosiderin 1 (2%)
Atrium, Thrombosis 5 (10%) 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (47) (49) (50)
Degeneration, Fatty 19 (40%) 30 (61%) 18 (36%)
Focal Cellular Change 3 (6%) 3 (6%) 3 (6%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 3 (6%)
Hyperplasia 6 (13%) 2 (4%) 3 (6%)
Hypertrophy 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 1 (2%)
Adrenal Gland, Medulla (46) (49) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 20 (43%) 15 (31%) 14 (28%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Islets, Pancreatic (47) (50) (48)
Cytomegaly 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (35) (33) (44)
Hyperplasia 4 (11%) 4 (9%)
Pituitary Gland (47) (50) (48)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 7 (15%) 10 (20%) 6 (13%)
Pars Intermedia, Degeneration, Cystic 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (45) (46) (48)
C-Cell, Hyperplasia 11 (24%) 5 (11%) 10 (21%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (40) (36) (39)
Granuloma Sperm 1 (3%)
Inflammation, Chronic 1 (3%)
Mineralization 1 (3%)
Necrosis 1 (3%)
Vacuolization Cytoplasmic 8 (20%) 4 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Serosa, Hyperplasia 1 (3%)
Preputial Gland (45) (48) (50)
Cyst 1 (2%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Suppurative 17 (38%) 15 (31%) 23 (46%)
Duct, Ectasia 1 (2%)
Duct, Hyperplasia 1 (2%)
Prostate (49) (49) (47)
Hemorrhage 1 (2%)
Inflammation, Suppurative 18 (37%) 23 (47%) 15 (32%)
Epithelium, Hyperplasia 7 (14%) 3 (6%) 9 (19%)
Seminal Vesicle (3) (3) (2)
Hemorrhage 1 (33%)
Inflammation, Suppurative 2 (67%) 3 (100%) 2 (100%)
Testes (50) (50) (50)
Atrophy 8 (16%) 11 (22%) 14 (28%)
Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 13 (26%) 9 (18%) 12 (24%)
Perivascular, Inflammation 5 (10%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (46) (49) (50)
Depletion Cellular 1 (2%)
Myelofibrosis 2 (4%) 3 (6%)
Lymph Node (48) (50) (49)
Mesenteric, Angiectasis 1 (2%)
Renal, Hyperplasia 1 (2%)
Lymph Node, Bronchial (44) (48) (46)
Angiectasis 2 (4%)
Congestion 1 (2%) 1 (2%)
Hyperplasia 2 (5%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mandibular (45) (43) (45)
Angiectasis 1 (2%) 1 (2%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 16 (36%) 16 (37%) 15 (33%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Spleen (48) (49) (49)
Developmental Malformation 1 (2%)
Ectopic Tissue 1 (2%)
Fibrosis 6 (13%) 8 (16%) 8 (16%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (23) (20) (23)
Galactocele 7 (30%) 4 (20%) 10 (43%)
Hyperplasia 10 (43%) 8 (40%) 8 (35%)
Skin (46) (49) (47)
Acanthosis 2 (4%)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Suppurative 1 (2%)
Prepuce, Inflammation, Suppurative 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 5 (11%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (47) (50) (50)
Fibrous Osteodystrophy 1 (2%) 3 (6%)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50)
Compression 2 (4%)
Hemorrhage 1 (2%) 7 (14%) 2 (4%)
Metaplasia, Osseous 1 (2%)
Thrombosis 1 (2%)
Spinal Cord (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (48) (49)
Inflammation, Suppurative 15 (31%) 14 (29%) 21 (43%)
Metaplasia, Squamous 2 (4%) 3 (6%)
Lung (49) (50) (50)
Congestion 3 (6%) 4 (8%)
Foreign Body 1 (2%)
Hemorrhage 2 (4%) 5 (10%) 7 (14%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic, Diffuse 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 13 (27%) 13 (26%) 5 (10%)
Inflammation, Focal, Granulomatous 2 (4%)
Leukocytosis 2 (4%) 2 (4%)
Metaplasia, Osseous 1 (2%)
Mineralization 2 (4%) 2 (4%)
Pigmentation, Hemosiderin 3 (6%) 2 (4%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 5 (10%) 6 (12%)
Alveolus, Infiltration Cellular, Histiocyte 11 (22%) 7 (14%) 8 (16%)
Alveolus, Inflammation, Suppurative 1 (2%)
Artery, Intima, Inflammation, Chronic 1 (2%)
Bronchiole, Inflammation, Suppurative 1 (2%) 1 (2%)
Bronchiole, Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Bronchus, Inflammation, Suppurative 2 (4%)
Bronchus, Epithelium, Hyperplasia 1 (2%)
Bronchus, Epithelium, Metaplasia, Squamous 1 (2%)
Peribronchial, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Peribronchiolar, Infiltration Cellular,
Mononuclear Cell 1 (2%)
Perivascular, Infiltration Cellular,
Mononuclear Cell 9 (18%) 7 (14%) 13 (26%)
Nose (46) (50) (49)
Foreign Body 3 (7%) 2 (4%) 3 (6%)
Inflammation 30 (65%) 34 (68%) 44 (90%)
Inflammation, Suppurative 26 (57%) 36 (72%) 46 (94%)
Thrombosis 7 (15%) 3 (6%) 5 (10%)
Mucosa, Cyst 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 9 (20%) 5 (10%) 14 (29%)
Olfactory Epithelium, Degeneration 4 (9%) 6 (12%)
Olfactory Epithelium, Metaplasia 4 (9%) 2 (4%) 7 (14%)
Respiratory Epithelium, Hyperplasia 12 (26%) 17 (34%) 44 (90%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 11 (22%) 27 (55%)
Vomeronasal Organ, Inflammation, Suppurative 2 (4%) 4 (8%) 6 (12%)
Trachea (46) (48) (49)
Inflammation 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 6 (13%) 5 (10%)
Mineralization 2 (4%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Epithelium, Metaplasia, Squamous 4 (9%) 6 (13%) 4 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:21:59
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (2) (50)
Synechia 1 (2%)
Anterior Chamber, Inflammation, Suppurative 2 (4%) 2 (4%)
Cornea, Hyperplasia 1 (2%)
Cornea, Inflammation, Suppurative 2 (4%) 3 (6%)
Cornea, Mineralization 3 (6%)
Lens, Degeneration 6 (12%) 7 (14%)
Lens, Mineralization 2 (4%)
Retina, Atrophy 1 (2%) 2 (4%)
Sclera, Inflammation 1 (2%)
Harderian Gland (1) (2)
Inflammation, Suppurative 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hydronephrosis 1 (2%)
Mineralization 2 (4%)
Nephropathy 48 (98%) 49 (100%) 48 (96%)
Pelvis, Inflammation, Suppurative 2 (4%)
Renal Tubule, Hyperplasia 2 (4%) 3 (6%) 1 (2%)
Renal Tubule, Inflammation, Suppurative 1 (2%)
Urinary Bladder (49) (50) (49)
Calculus Gross Observation 2 (4%)
Calculus Micro Observation Only 2 (4%)
Hemorrhage 2 (4%) 1 (2%)
Inflammation, Suppurative 3 (6%) 2 (4%) 1 (2%)
Mineralization 1 (2%)
Transitional Epithelium, Hyperplasia 5 (10%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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