TDMS Study 05097-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ALPHA-CHLOROACETOPHENONE
NTP Experiment-Test: 05097-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
Facility: Battelle Northwest
Chemical CAS #: 532-27-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 22 28 22
Dead 5 2 4
Survivors
Terminal Sacrifice 23 20 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (28) (41)
Leiomyoma 1 (2%)
Intestine Large, Colon (48) (28) (48)
Intestine Small, Ileum (46) (27) (45)
Intestine Small, Jejunum (48) (28) (46)
Liver (49) (41) (49)
Mesentery (6) (2) (2)
Sarcoma 1 (17%)
Pancreas (49) (30) (47)
Acinus, Adenoma 1 (2%)
Salivary Glands (49) (29) (49)
Stomach, Forestomach (47) (49) (49)
Stomach, Glandular (49) (50) (49)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (30) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (48)
Adenoma 5 (10%) 4 (8%) 4 (8%)
Carcinoma 1 (2%)
Sarcoma, Metastatic, Uterus 1 (2%)
Adrenal Gland, Medulla (49) (50) (48)
Ganglioneuroma 1 (2%)
Pheochromocytoma Benign 3 (6%) 4 (8%) 3 (6%)
Bilateral, Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (48) (29) (46)
Page 2
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Adenoma 2 (4%) 1 (2%)
Carcinoma 2 (4%)
Parathyroid Gland (32) (22) (38)
Adenoma 1 (3%)
Pituitary Gland (49) (48) (49)
Pars Distalis, Adenoma 27 (55%) 40 (83%) 30 (61%)
Pars Distalis, Carcinoma 3 (6%) 5 (10%)
Thyroid Gland (47) (30) (45)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 1 (2%) 3 (10%) 6 (13%)
Follicular Cell, Adenocarcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (45) (33) (42)
Adenoma 5 (11%) 2 (6%) 2 (5%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (3%) 1 (2%)
Ovary (49) (31) (49)
Adenoma 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Uterus (49) (33) (48)
Adenocarcinoma 1 (2%)
Adenoma 2 (4%)
Deciduoma Benign 1 (2%)
Fibroma 1 (2%)
Polyp Stromal 6 (12%) 6 (18%) 5 (10%)
Sarcoma Stromal 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (30) (47)
Lymph Node (49) (31) (49)
Lymph Node, Bronchial (44) (26) (41)
Lymph Node, Mandibular (46) (30) (47)
Spleen (49) (35) (49)
Thymus (38) (24) (46)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (50)
Adenocarcinoma 2 (4%) 2 (4%) 1 (2%)
Adenoma 2 (4%) 1 (2%)
Fibroadenoma 11 (23%) 15 (30%) 21 (42%)
Fibroadenoma, Multiple 1 (2%) 4 (8%) 2 (4%)
Skin (49) (27) (47)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Thoracic, Subcutaneous Tissue, Ventral,
Leukemia Mononuclear 4 (8%) 1 (4%) 4 (9%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (30) (50)
Carcinoma, Metastatic, Pituitary Gland 3 (6%) 5 (10%)
Glioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (40) (49)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (3%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Adrenal Gland 1 (2%)
Neoplasm NOS, Metastatic, Uncertain Primary
Site 1 (3%)
Sarcoma, Metastatic, Uterus 1 (2%)
Mediastinum, Hemangioma 1 (2%)
Mediastinum, Sarcoma 1 (2%)
Nose (48) (50) (49)
Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (2) (48)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (37) (49)
Capsule, Sarcoma, Metastatic, Uterus 1 (2%)
Renal Tubule, Adenoma 1 (3%)
Urinary Bladder (48) (31) (48)
Transitional Epithelium, Papilloma 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 27 (54%) 23 (46%) 20 (40%)
Lymphoma Malignant Histiocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1 MG/M3 2 MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 50 48
Total Primary Neoplasms 113 110 120
Total Animals with Benign Neoplasms 39 47 43
Total Benign Neoplasms 74 83 84
Total Animals with Malignant Neoplasms 32 26 29
Total Malignant Neoplasms 39 27 36
Total Animals with Metastatic Neoplasms 3 1 7
Total Metastatic Neoplasm 3 1 9
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 26 22 24
Dead 10 6 9
Survivors
Terminal Sacrifice 14 22 17
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (44) (47) (46)
Intestine Small, Duodenum (43) (45) (45)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (41) (45) (43)
Intestine Small, Jejunum (43) (44) (40)
Liver (49) (50) (50)
Adenoma 1 (2%)
Mesentery (2) (3) (3)
Pancreas (47) (50) (49)
Acinus, Adenoma 1 (2%)
Pharynx (3)
Palate, Squamous Cell Papilloma 3 (100%)
Salivary Glands (46) (49) (49)
Stomach, Forestomach (46) (49) (49)
Stomach, Glandular (48) (49) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (47) (49) (50)
Adenoma 1 (2%) 2 (4%) 1 (2%)
Adrenal Gland, Medulla (46) (49) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%) 2 (4%)
Pheochromocytoma Benign 11 (24%) 10 (20%) 16 (32%)
Bilateral, Pheochromocytoma Benign 3 (7%) 5 (10%) 4 (8%)
Islets, Pancreatic (47) (50) (48)
Adenoma 3 (6%) 6 (12%) 1 (2%)
Adenoma, Multiple 1 (2%)
Page 7
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Carcinoma 1 (2%)
Parathyroid Gland (35) (33) (44)
Adenoma 2 (6%) 1 (2%)
Pituitary Gland (47) (50) (48)
Pars Distalis, Adenoma 31 (66%) 35 (70%) 32 (67%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (45) (46) (48)
C-Cell, Adenoma 5 (11%) 5 (11%) 2 (4%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Adenocarcinoma 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Chordoma 1 (50%)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (40) (36) (39)
Penis (1)
Preputial Gland (45) (48) (50)
Adenoma 2 (4%) 6 (13%) 5 (10%)
Carcinoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Prostate (49) (49) (47)
Adenoma 1 (2%)
Testes (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 18 (36%) 21 (42%) 20 (40%)
Interstitial Cell, Adenoma 11 (22%) 10 (20%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (46) (49) (50)
Lymph Node (48) (50) (49)
Lymph Node, Bronchial (44) (48) (46)
Sarcoma, Metastatic 1 (2%)
Lymph Node, Mandibular (45) (43) (45)
Spleen (48) (49) (49)
Thymus (33) (38) (41)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (23) (20) (23)
Adenocarcinoma 1 (5%)
Adenoma 1 (4%)
Fibroadenoma 1 (5%)
Skin (46) (49) (47)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Keratoacanthoma 4 (9%) 2 (4%) 4 (9%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (47) (50) (50)
Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Hemangioma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
Glioma Benign 1 (2%)
Glioma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Neoplasm NOS, Metastatic, Tissue NOS 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Sarcoma, Metastatic, Eye 1 (2%)
Sarcoma, Metastatic, Tissue NOS 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Page 9
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Nose (46) (50) (49)
Carcinoma, Metastatic, Skin 1 (2%)
Trachea (46) (48) (49)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (2) (50)
Sarcoma 1 (50%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (49) (50)
Lipoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (49) (50) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 29 (58%) 26 (52%) 27 (54%)
Mesothelioma Benign 2 (4%) 2 (4%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05097-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:22:01
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1 MG/M3 2 MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 50 49
Total Primary Neoplasms 145 151 138
Total Animals with Benign Neoplasms 44 48 48
Total Benign Neoplasms 102 113 102
Total Animals with Malignant Neoplasms 34 35 30
Total Malignant Neoplasms 43 38 36
Total Animals with Metastatic Neoplasms 4 4 2
Total Metastatic Neoplasm 7 5 2
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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