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TDMS Study 05097-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                      ALPHA-CHLOROACETOPHENONE


NTP Experiment-Test: 05097-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01




       Facility:  Battelle Northwest

       Chemical CAS #:  532-27-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          22           28           22                                                  
    Dead                                               5            2            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           20           24                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (28)         (41)                                                
      Leiomyoma                                                                  1 (2%)                                             
   Intestine Large, Colon                             (48)         (28)         (48)                                                
   Intestine Small, Ileum                             (46)         (27)         (45)                                                
   Intestine Small, Jejunum                           (48)         (28)         (46)                                                
   Liver                                              (49)         (41)         (49)                                                
   Mesentery                                          (6)          (2)          (2)                                                 
      Sarcoma                                          1 (17%)                                                                      
   Pancreas                                           (49)         (30)         (47)                                                
      Acinus, Adenoma                                                            1 (2%)                                             
   Salivary Glands                                    (49)         (29)         (49)                                                
   Stomach, Forestomach                               (47)         (49)         (49)                                                
   Stomach, Glandular                                 (49)         (50)         (49)                                                
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (30)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (48)                                                
      Adenoma                                          5 (10%)      4 (8%)       4 (8%)                                             
      Carcinoma                                                                  1 (2%)                                             
      Sarcoma, Metastatic, Uterus                                                1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (48)                                                
      Ganglioneuroma                                   1 (2%)                                                                       
      Pheochromocytoma Benign                          3 (6%)       4 (8%)       3 (6%)                                             
      Bilateral, Pheochromocytoma Benign               2 (4%)                                                                       
   Islets, Pancreatic                                 (48)         (29)         (46)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                          2 (4%)                    1 (2%)                                             
      Carcinoma                                                                  2 (4%)                                             
   Parathyroid Gland                                  (32)         (22)         (38)                                                
      Adenoma                                                                    1 (3%)                                             
   Pituitary Gland                                    (49)         (48)         (49)                                                
      Pars Distalis, Adenoma                          27 (55%)     40 (83%)     30 (61%)                                            
      Pars Distalis, Carcinoma                         3 (6%)                    5 (10%)                                            
   Thyroid Gland                                      (47)         (30)         (45)                                                
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  1 (2%)       3 (10%)      6 (13%)                                            
      Follicular Cell, Adenocarcinoma                  2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (33)         (42)                                                
      Adenoma                                          5 (11%)      2 (6%)       2 (5%)                                             
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                                     1 (3%)       1 (2%)                                             
   Ovary                                              (49)         (31)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Granulosa-Theca Tumor Malignant                  1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
   Uterus                                             (49)         (33)         (48)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Adenoma                                          2 (4%)                                                                       
      Deciduoma Benign                                                           1 (2%)                                             
      Fibroma                                          1 (2%)                                                                       
      Polyp Stromal                                    6 (12%)      6 (18%)      5 (10%)                                            
      Sarcoma Stromal                                               1 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (30)         (47)                                                
   Lymph Node                                         (49)         (31)         (49)                                                
   Lymph Node, Bronchial                              (44)         (26)         (41)                                                
   Lymph Node, Mandibular                             (46)         (30)         (47)                                                
   Spleen                                             (49)         (35)         (49)                                                
   Thymus                                             (38)         (24)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)         (50)                                                
      Adenocarcinoma                                   2 (4%)       2 (4%)       1 (2%)                                             
      Adenoma                                                       2 (4%)       1 (2%)                                             
      Fibroadenoma                                    11 (23%)     15 (30%)     21 (42%)                                            
      Fibroadenoma, Multiple                           1 (2%)       4 (8%)       2 (4%)                                             
   Skin                                               (49)         (27)         (47)                                                
      Keratoacanthoma                                  1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Thoracic, Subcutaneous Tissue, Ventral,                                                                                       
          Leukemia Mononuclear                         4 (8%)       1 (4%)       4 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
      Schwannoma Malignant                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (30)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland           3 (6%)                    5 (10%)                                            
      Glioma Benign                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (40)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (3%)                                                          
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Adrenal Gland                                       1 (2%)                                             
      Neoplasm NOS, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (3%)                                                          
      Sarcoma, Metastatic, Uterus                                                1 (2%)                                             
      Mediastinum, Hemangioma                          1 (2%)                                                                       
      Mediastinum, Sarcoma                                                       1 (2%)                                             
   Nose                                               (48)         (50)         (49)                                                
      Fibrosarcoma                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (2)          (48)                                                
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (37)         (49)                                                
      Capsule, Sarcoma, Metastatic, Uterus                                       1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (3%)                                                          
   Urinary Bladder                                    (48)         (31)         (48)                                                
      Transitional Epithelium, Papilloma               1 (2%)       1 (3%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            27 (54%)     23 (46%)     20 (40%)                                            
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      1 MG/M3      2 MG/M3                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          50          48                                                   
     Total Primary Neoplasms                          113         110         120                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          47          43                                                   
     Total Benign Neoplasms                            74          83          84                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              32          26          29                                                   
     Total Malignant Neoplasms                         39          27          36                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1           7                                                   
     Total Metastatic Neoplasm                          3           1           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          26           22           24                                                  
    Dead                                              10            6            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           22           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (44)         (47)         (46)                                                
   Intestine Small, Duodenum                          (43)         (45)         (45)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (41)         (45)         (43)                                                
   Intestine Small, Jejunum                           (43)         (44)         (40)                                                
   Liver                                              (49)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Mesentery                                          (2)          (3)          (3)                                                 
   Pancreas                                           (47)         (50)         (49)                                                
      Acinus, Adenoma                                               1 (2%)                                                          
   Pharynx                                            (3)                                                                           
      Palate, Squamous Cell Papilloma                  3 (100%)                                                                     
   Salivary Glands                                    (46)         (49)         (49)                                                
   Stomach, Forestomach                               (46)         (49)         (49)                                                
   Stomach, Glandular                                 (48)         (49)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (47)         (49)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (46)         (49)         (50)                                                
      Pheochromocytoma Malignant                       2 (4%)       1 (2%)       2 (4%)                                             
      Pheochromocytoma Benign                         11 (24%)     10 (20%)     16 (32%)                                            
      Bilateral, Pheochromocytoma Benign               3 (7%)       5 (10%)      4 (8%)                                             
   Islets, Pancreatic                                 (47)         (50)         (48)                                                
      Adenoma                                          3 (6%)       6 (12%)      1 (2%)                                             
      Adenoma, Multiple                                             1 (2%)                                                          
                                                             Page   7                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (35)         (33)         (44)                                                
      Adenoma                                                       2 (6%)       1 (2%)                                             
   Pituitary Gland                                    (47)         (50)         (48)                                                
      Pars Distalis, Adenoma                          31 (66%)     35 (70%)     32 (67%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (45)         (46)         (48)                                                
      C-Cell, Adenoma                                  5 (11%)      5 (11%)      2 (4%)                                             
      C-Cell, Carcinoma                                2 (4%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Adenocarcinoma                               2 (4%)       1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                                                                           
      Chordoma                                         1 (50%)                                                                      
      Sarcoma                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (40)         (36)         (39)                                                
   Penis                                                           (1)                                                              
   Preputial Gland                                    (45)         (48)         (50)                                                
      Adenoma                                          2 (4%)       6 (13%)      5 (10%)                                            
      Carcinoma                                                     1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Prostate                                           (49)         (49)         (47)                                                
      Adenoma                                          1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           18 (36%)     21 (42%)     20 (40%)                                            
      Interstitial Cell, Adenoma                      11 (22%)     10 (20%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (46)         (49)         (50)                                                
   Lymph Node                                         (48)         (50)         (49)                                                
   Lymph Node, Bronchial                              (44)         (48)         (46)                                                
      Sarcoma, Metastatic                              1 (2%)                                                                       
   Lymph Node, Mandibular                             (45)         (43)         (45)                                                
   Spleen                                             (48)         (49)         (49)                                                
   Thymus                                             (33)         (38)         (41)                                                
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (23)         (20)         (23)                                                
      Adenocarcinoma                                                1 (5%)                                                          
      Adenoma                                                                    1 (4%)                                             
      Fibroadenoma                                                  1 (5%)                                                          
   Skin                                               (46)         (49)         (47)                                                
      Basal Cell Adenoma                                                         1 (2%)                                             
      Basal Cell Carcinoma                             1 (2%)                    1 (2%)                                             
      Keratoacanthoma                                  4 (9%)       2 (4%)       4 (9%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma           1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (47)         (50)         (50)                                                
      Femur, Osteosarcoma                                           1 (2%)                                                          
   Skeletal Muscle                                                              (1)                                                 
      Hemangioma                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                    1 (2%)                                             
      Glioma Benign                                    1 (2%)                                                                       
      Glioma Malignant                                 1 (2%)                                                                       
      Granular Cell Tumor Benign                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Neoplasm NOS, Metastatic, Tissue NOS             1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
      Sarcoma, Metastatic, Eye                                      1 (2%)                                                          
      Sarcoma, Metastatic, Tissue NOS                  1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Skin                     1 (2%)                                                          
                                                             Page   9                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
   Nose                                               (46)         (50)         (49)                                                
      Carcinoma, Metastatic, Skin                                                1 (2%)                                             
   Trachea                                            (46)         (48)         (49)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (2)          (50)                                                
      Sarcoma                                                       1 (50%)                                                         
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (50)                                                
      Lipoma                                           1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            29 (58%)     26 (52%)     27 (54%)                                            
      Mesothelioma Benign                              2 (4%)       2 (4%)                                                          
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05097-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:22:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      1 MG/M3      2 MG/M3                                                
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          50          49                                                   
     Total Primary Neoplasms                          145         151         138                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          48          48                                                   
     Total Benign Neoplasms                           102         113         102                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          35          30                                                   
     Total Malignant Neoplasms                         43          38          36                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           4           2                                                   
     Total Metastatic Neoplasm                          7           5           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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