TDMS Study 05097-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ALPHA-CHLOROACETOPHENONE DATE: 09/13/94
EXPERIMENT: 05097 TEST: 01 TIME: 06:34:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55107
PATHOLOGIST: R. MILLER CAS: 532-27-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ALPHA-CHLOROACETOPHENONE DATE: 09/13/94
EXPERIMENT: 05097 TEST: 01 TIME: 06:34:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55107
PATHOLOGIST: R. MILLER CAS: 532-27-4
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ALPHA-CHLOROACETOPHENONE DATE: 09/13/94
EXPERIMENT: 05097 TEST: 01 TIME: 06:34:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 55107
PATHOLOGIST: R. MILLER CAS: 532-27-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ALPHA-CHLOROACETOPHENONE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)
Papilloma Squamous or Papilloma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Pharynx Squamous Cell Papilloma
All Organs Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Carcinoma
Carcinoma or Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 2/49 (4%) 1/50 (2%) | 5/49 (10%) 4/50 (8%) 4/48 (8%) |
|ADJUSTED (b) | 5.0% 9.1% 5.9% | 19.2% 14.9% 16.7% |
|TERMINAL (d) | 0/14 (0%) 2/22 (9%) 1/17 (6%) | 3/23 (13%) 2/20 (10%) 4/24 (17%) |
|FIRST INCIDENCE (DAYS) | 715 735 (T) 735 (T) | 679 640 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.586N P=0.629 P=0.739N | P=0.399N P=0.542N P=0.473N |
|INCIDENTAL TUMOR | P=0.619N P=0.552 P=0.742 | P=0.451N P=0.481N P=0.490N |
|LOGISTIC REGRESSION | P=0.611N P=0.591 P=0.756N | P=0.424N P=0.479N P=0.481N |
|COCHRAN-ARMITAGE | P=0.603N | P=0.441N |
|FISHER EXACT | P=0.516 P=0.737N | P=0.487N P=0.513N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/46 (30%) 15/49 (31%) 20/50 (40%) | 5/49 (10%) 4/50 (8%) 3/48 (6%) |
|ADJUSTED (b) | 56.1% 51.2% 71.1% | 16.6% 15.6% 12.1% |
|TERMINAL (d) | 5/14 (36%) 8/22 (36%) 10/17 (59%) | 2/23 (9%) 2/20 (10%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 602 631 532 | 602 626 705 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.186 P=0.303N P=0.229 | P=0.288N P=0.512N P=0.350N |
|INCIDENTAL TUMOR | P=0.117 P=0.526 P=0.174 | P=0.377N P=0.494N P=0.463N |
|LOGISTIC REGRESSION | P=0.124 P=0.483N P=0.165 | P=0.301N P=0.476N P=0.371N |
|COCHRAN-ARMITAGE | P=0.185 | P=0.299N |
|FISHER EXACT | P=0.581 P=0.222 | P=0.487N P=0.369N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/46 (4%) 1/49 (2%) 2/50 (4%) | 0/49 (0%) 0/50 (0%) 0/48 (0%) |
|ADJUSTED (b) | 9.8% 4.5% 5.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/14 (7%) 1/22 (5%) 0/17 (0%) | 0/23 (0%) 0/20 (0%) 0/23 (0%) |
|FIRST INCIDENCE (DAYS) | 619 735 (T) 539 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.586N P=0.390N P=0.672N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.522N P=0.375N P=0.619N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.580N P=0.458N P=0.661N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.580N | (e) |
|FISHER EXACT | P=0.476N P=0.659N | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/46 (33%) 16/49 (33%) 21/50 (42%) | 5/49 (10%) 4/50 (8%) 3/48 (6%) |
|ADJUSTED (b) | 57.3% 54.7% 72.2% | 16.6% 15.6% 12.1% |
|TERMINAL (d) | 5/14 (36%) 9/22 (41%) 10/17 (59%) | 2/23 (9%) 2/20 (10%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 602 631 532 | 602 626 705 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.197 P=0.290N P=0.238 | P=0.288N P=0.512N P=0.350N |
|INCIDENTAL TUMOR | P=0.116 P=0.554 P=0.167 | P=0.377N P=0.494N P=0.463N |
|LOGISTIC REGRESSION | P=0.130 P=0.479N P=0.173 | P=0.301N P=0.476N P=0.371N |
|COCHRAN-ARMITAGE | P=0.193 | P=0.299N |
|FISHER EXACT | P=0.585 P=0.230 | P=0.487N P=0.369N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 1/50 (2%) | 0/49 (0%) 0/30 (0%) 1/50 (2%) |
|ADJUSTED (b) | 5.4% 0.0% 2.0% | 0.0% 0.0% 4.2% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 0/17 (0%) | 0/23 (0%) 0/0 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 577 --- 444 | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.376N P=0.237N P=0.520N | P=0.316 (e) P=0.508 |
|INCIDENTAL TUMOR | P=0.320N P=0.272N P=0.461N | P=0.316 (e) P=0.508 |
|LOGISTIC REGRESSION | P=0.350N P=0.242N P=0.487N | P=0.316 (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.355N | P=0.286 |
|FISHER EXACT | P=0.242N P=0.492N | (e) P=0.505 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/45 (4%) 6/48 (13%) 5/50 (10%) | 5/45 (11%) 2/33 (6%) 3/42 (7%) |
|ADJUSTED (b) | 12.3% 23.7% 25.7% | 17.8% 40.0% 11.8% |
|TERMINAL (d) | 1/13 (8%) 4/22 (18%) 4/17 (24%) | 3/22 (14%) 2/5 (40%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 715 631 605 | 577 735 (T) 700 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248 P=0.308 P=0.293 | P=0.272N P=0.675 P=0.340N |
|INCIDENTAL TUMOR | P=0.208 P=0.206 P=0.264 | P=0.360N P=0.640 P=0.512N |
|LOGISTIC REGRESSION | P=0.199 P=0.209 P=0.238 | P=0.306N P=0.420N P=0.396N |
|COCHRAN-ARMITAGE | P=0.232 | P=0.314N |
|FISHER EXACT | P=0.156 P=0.264 | P=0.363N P=0.396N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/45 (4%) 7/48 (15%) 5/50 (10%) | 5/45 (11%) 3/33 (9%) 4/42 (10%) |
|ADJUSTED (b) | 12.3% 27.9% 25.7% | 17.8% 42.9% 14.2% |
|TERMINAL (d) | 1/13 (8%) 5/22 (23%) 4/17 (24%) | 3/22 (14%) 2/5 (40%) 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 715 631 605 | 577 731 666 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.263 P=0.228 P=0.293 | P=0.405N P=0.480 P=0.470N |
|INCIDENTAL TUMOR | P=0.222 P=0.146 P=0.264 | P=0.514N P=0.488 P=0.625 |
|LOGISTIC REGRESSION | P=0.209 P=0.141 P=0.238 | P=0.460N P=0.640N P=0.547N |
|COCHRAN-ARMITAGE | P=0.244 | P=0.471N |
|FISHER EXACT | P=0.095 P=0.264 | P=0.541N P=0.544N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/47 (6%) 7/50 (14%) 1/48 (2%) | 2/48 (4%) 0/29 (0%) 1/46 (2%) |
|ADJUSTED (b) | 19.3% 20.1% 2.9% | 9.1% 0.0% 4.3% |
|TERMINAL (d) | 2/14 (14%) 1/22 (5%) 0/17 (0%) | 2/22 (9%) 0/0 1/23 (4%) |
|FIRST INCIDENCE (DAYS) | 722 556 612 | 735 (T) --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.279N P=0.278 P=0.266N | P=0.369N (e) P=0.484N |
|INCIDENTAL TUMOR | P=0.368N P=0.159 P=0.325N | P=0.369N (e) P=0.484N |
|LOGISTIC REGRESSION | P=0.274N P=0.190 P=0.305N | P=0.369N (e) P=0.484N |
|COCHRAN-ARMITAGE | P=0.271N | P=0.381N |
|FISHER EXACT | P=0.185 P=0.301N | P=0.386N P=0.516N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 0/50 (0%) 0/48 (0%) | 0/48 (0%) 0/29 (0%) 2/46 (4%) |
|ADJUSTED (b) | 7.1% 0.0% 0.0% | 0.0% 0.0% 8.7% |
|TERMINAL (d) | 1/14 (7%) 0/22 (0%) 0/17 (0%) | 0/22 (0%) 0/0 2/23 (9%) |
|FIRST INCIDENCE (DAYS) | 735 (T) --- --- | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.233N P=0.410N P=0.461N | P=0.149 (e) P=0.247 |
|INCIDENTAL TUMOR | P=0.233N P=0.410N P=0.461N | P=0.149 (e) P=0.247 |
|LOGISTIC REGRESSION | P=0.231N P=0.410N P=0.461N | P=0.149 (e) P=0.247 |
|COCHRAN-ARMITAGE | P=0.265N | P=0.106 |
|FISHER EXACT | P=0.485N P=0.495N | (e) P=0.237 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/47 (9%) 7/50 (14%) 1/48 (2%) | 2/48 (4%) 0/29 (0%) 3/46 (7%) |
|ADJUSTED (b) | 26.1% 20.1% 2.9% | 9.1% 0.0% 13.0% |
|TERMINAL (d) | 3/14 (21%) 1/22 (5%) 0/17 (0%) | 2/22 (9%) 0/0 3/23 (13%) |
|FIRST INCIDENCE (DAYS) | 722 556 612 | 735 (T) --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.169N P=0.426 P=0.143N | P=0.428 (e) P=0.521 |
|INCIDENTAL TUMOR | P=0.234N P=0.287 P=0.180N | P=0.428 (e) P=0.521 |
|LOGISTIC REGRESSION | P=0.171N P=0.309 P=0.177N | P=0.428 (e) P=0.521 |
|COCHRAN-ARMITAGE | P=0.168N | P=0.381 |
|FISHER EXACT | P=0.299 P=0.174N | P=0.386N P=0.480 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 2/50 (4%) 1/50 (2%) | 1/49 (2%) 1/40 (3%) 1/49 (2%) |
|ADJUSTED (b) | 12.6% 7.1% 2.9% | 4.3% 10.0% 4.2% |
|TERMINAL (d) | 1/14 (7%) 1/22 (5%) 0/17 (0%) | 1/23 (4%) 1/10 (10%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 722 631 630 | 735 (T) 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359N P=0.570N P=0.465N | P=0.614N P=0.566 P=0.753N |
|INCIDENTAL TUMOR | P=0.411N P=0.643N P=0.539N | P=0.614N P=0.566 P=0.753N |
|LOGISTIC REGRESSION | P=0.389N P=0.657N P=0.502N | P=0.614N P=0.566 P=0.753N |
|COCHRAN-ARMITAGE | P=0.383N | P=0.635N |
|FISHER EXACT | P=0.684N P=0.492N | P=0.700 P=0.753N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 5.9% | 0.0% 7.6% 3.1% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 1/17 (6%) | 0/23 (0%) 1/20 (5%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 735 (T) | --- 658 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.281 (e) P=0.539 | P=0.383 P=0.230 P=0.520 |
|INCIDENTAL TUMOR | P=0.281 (e) P=0.539 | P=0.361 P=0.259 P=0.500 |
|LOGISTIC REGRESSION | P=0.281 (e) P=0.539 | P=0.359 P=0.245 P=0.500 |
|COCHRAN-ARMITAGE | P=0.269 | P=0.360 |
|FISHER EXACT | (e) P=0.500 | P=0.247 P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 4.5% 0.0% | 8.7% 8.0% 4.2% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 0/17 (0%) | 2/23 (9%) 0/20 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) --- | 735 (T) 707 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.719N P=0.590 (e) | P=0.378N P=0.668 P=0.485N |
|INCIDENTAL TUMOR | P=0.719N P=0.590 (e) | P=0.380N P=0.662N P=0.485N |
|LOGISTIC REGRESSION | P=0.719N P=0.590 (e) | P=0.375N P=0.697N P=0.485N |
|COCHRAN-ARMITAGE | P=0.731 | P=0.390N |
|FISHER EXACT | P=0.500 (e) | P=0.691N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | 2/50 (4%) 4/50 (8%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 4.5% 5.9% | 8.7% 15.0% 7.2% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 1/17 (6%) | 2/23 (9%) 1/20 (5%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) 735 (T) | 735 (T) 658 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359 P=0.590 P=0.539 | P=0.561N P=0.312 P=0.674N |
|INCIDENTAL TUMOR | P=0.359 P=0.590 P=0.539 | P=0.579N P=0.379 P=0.683N |
|LOGISTIC REGRESSION | P=0.359 P=0.590 P=0.539 | P=0.581N P=0.347 P=0.684N |
|COCHRAN-ARMITAGE | P=0.331 | P=0.588N |
|FISHER EXACT | P=0.500 P=0.500 | P=0.339 P=0.691N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 12/50 (24%) 19/50 (38%) 23/50 (46%) |
|ADJUSTED (b) | 0.0% 4.5% 0.0% | 42.2% 64.4% 61.9% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 0/17 (0%) | 8/23 (35%) 11/20 (55%) 11/24 (46%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) --- | 533 553 490 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.719N P=0.590 (e) | P=0.031 * P=0.070 P=0.038 * |
|INCIDENTAL TUMOR | P=0.719N P=0.590 (e) | P=0.023 * P=0.075 P=0.034 * |
|LOGISTIC REGRESSION | P=0.719N P=0.590 (e) | P=0.013 * P=0.117 P=0.017 * |
|COCHRAN-ARMITAGE | P=0.731 | P=0.014 * |
|FISHER EXACT | P=0.500 (e) | P=0.097 P=0.018 * |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 1/50 (2%) | 12/50 (24%) 20/50 (40%) 23/50 (46%) |
|ADJUSTED (b) | 0.0% 4.5% 5.9% | 42.2% 65.4% 61.9% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 1/17 (6%) | 8/23 (35%) 11/20 (55%) 11/24 (46%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) 735 (T) | 533 553 490 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.359 P=0.590 P=0.539 | P=0.033 * P=0.050 P=0.038 * |
|INCIDENTAL TUMOR | P=0.359 P=0.590 P=0.539 | P=0.023 * P=0.054 P=0.034 * |
|LOGISTIC REGRESSION | P=0.359 P=0.590 P=0.539 | P=0.013 * P=0.082 P=0.017 * |
|COCHRAN-ARMITAGE | P=0.331 | P=0.015 * |
|FISHER EXACT | P=0.500 P=0.500 | P=0.066 P=0.018 * |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 13/50 (26%) 22/50 (44%) 23/50 (46%) |
|ADJUSTED (b) | 0.0% 9.1% 5.9% | 46.0% 68.2% 61.9% |
|TERMINAL (d) | 0/14 (0%) 2/22 (9%) 1/17 (6%) | 9/23 (39%) 11/20 (55%) 11/24 (46%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) 735 (T) | 533 553 490 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.399 P=0.341 P=0.539 | P=0.054 P=0.037 * P=0.057 |
|INCIDENTAL TUMOR | P=0.399 P=0.341 P=0.539 | P=0.039 * P=0.042 * P=0.055 |
|LOGISTIC REGRESSION | P=0.399 P=0.341 P=0.539 | P=0.022 * P=0.058 P=0.028 * |
|COCHRAN-ARMITAGE | P=0.360 | P=0.026 * |
|FISHER EXACT | P=0.247 P=0.500 | P=0.046 * P=0.030 * |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 12.0% 0.0% 0.0% | 0.0% 0.0% 4.2% |
|TERMINAL (d) | 1/14 (7%) 0/22 (0%) 0/17 (0%) | 0/23 (0%) 0/20 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 577 --- --- | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.036N* P=0.100N P=0.126N | P=0.281 (e) P=0.508 |
|INCIDENTAL TUMOR | P=0.043N* P=0.112N P=0.143N | P=0.281 (e) P=0.508 |
|LOGISTIC REGRESSION | P=0.037N* P=0.121N P=0.121N | P=0.281 (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.269 |
|FISHER EXACT | P=0.121N P=0.121N | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 12.0% 0.0% 0.0% | 0.0% 0.0% 4.2% |
|TERMINAL (d) | 1/14 (7%) 0/22 (0%) 0/17 (0%) | 0/23 (0%) 0/20 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 577 --- --- | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.036N* P=0.100N P=0.126N | P=0.281 (e) P=0.508 |
|INCIDENTAL TUMOR | P=0.043N* P=0.112N P=0.143N | P=0.281 (e) P=0.508 |
|LOGISTIC REGRESSION | P=0.037N* P=0.121N P=0.121N | P=0.281 (e) P=0.508 |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.269 |
|FISHER EXACT | P=0.121N P=0.121N | (e) P=0.500 |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/35 (0%) 2/33 (6%) 1/44 (2%) | 0/32 (0%) 0/22 (0%) 1/38 (3%) |
|ADJUSTED (b) | 0.0% 6.8% 6.7% | 0.0% 0.0% 5.6% |
|TERMINAL (d) | 0/8 (0%) 0/16 (0%) 1/15 (7%) | 0/19 (0%) 0/0 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | --- 700 735 (T) | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.385 P=0.287 P=0.625 | P=0.299 (e) P=0.489 |
|INCIDENTAL TUMOR | P=0.339 P=0.072 P=0.625 | P=0.299 (e) P=0.489 |
|LOGISTIC REGRESSION | P=0.421 P=0.242 P=0.625 | P=0.299 (e) P=0.489 |
|COCHRAN-ARMITAGE | P=0.428 | P=0.308 |
|FISHER EXACT | P=0.232 P=0.557 | (e) P=0.543 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Pharynx |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 12.0% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/14 (7%) 0/22 (0%) 0/17 (0%) | 0/23 (0%) 0/20 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 577 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.036N* P=0.100N P=0.126N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.043N* P=0.112N P=0.143N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.037N* P=0.121N P=0.121N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.037N* | (e) |
|FISHER EXACT | P=0.121N P=0.121N | (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 31/47 (66%) 35/50 (70%) 32/48 (67%) | 27/49 (55%) 40/48 (83%) 30/49 (61%) |
|ADJUSTED (b) | 84.4% 86.8% 77.7% | 73.1% 90.2% 84.8% |
|TERMINAL (d) | 8/13 (62%) 17/22 (77%) 8/16 (50%) | 14/23 (61%) 14/18 (78%) 19/24 (79%) |
|FIRST INCIDENCE (DAYS) | 318 449 444 | 533 553 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.491N P=0.273N P=0.523N | P=0.427 P=0.017 * P=0.442 |
|INCIDENTAL TUMOR | P=0.465 P=0.381 P=0.479 | P=0.165 P=0.006 ** P=0.267 |
|LOGISTIC REGRESSION | P=0.495 P=0.452 P=0.550 | P=0.270 P=0.003 ** P=0.316 |
|COCHRAN-ARMITAGE | P=0.515 | P=0.296 |
|FISHER EXACT | P=0.417 P=0.557 | P=0.002 ** P=0.341 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/47 (2%) 0/50 (0%) 1/48 (2%) | 3/49 (6%) 0/48 (0%) 5/49 (10%) |
|ADJUSTED (b) | 7.7% 0.0% 2.6% | 12.3% 0.0% 16.8% |
|TERMINAL (d) | 1/13 (8%) 0/22 (0%) 0/16 (0%) | 2/23 (9%) 0/18 (0%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | 735 (T) --- 559 | 731 --- 523 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.669N P=0.395N P=0.751N | P=0.271 P=0.161N P=0.374 |
|INCIDENTAL TUMOR | P=0.676 P=0.395N P=0.760 | P=0.357 P=0.130N P=0.470 |
|LOGISTIC REGRESSION | P=0.663N P=0.395N P=0.757N | P=0.252 P=0.152N P=0.355 |
|COCHRAN-ARMITAGE | P=0.666N | P=0.253 |
|FISHER EXACT | P=0.485N P=0.747N | P=0.125N P=0.357 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 32/47 (68%) 35/50 (70%) 33/48 (69%) | 30/49 (61%) 40/48 (83%) 35/49 (71%) |
|ADJUSTED (b) | 87.5% 86.8% 78.3% | 80.0% 90.2% 91.7% |
|TERMINAL (d) | 9/13 (69%) 17/22 (77%) 8/16 (50%) | 16/23 (70%) 14/18 (78%) 21/24 (88%) |
|FIRST INCIDENCE (DAYS) | 318 449 444 | 533 553 512 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.489N P=0.215N P=0.521N | P=0.318 P=0.043 * P=0.323 |
|INCIDENTAL TUMOR | P=0.464 P=0.488 P=0.478 | P=0.089 P=0.025 * P=0.174 |
|LOGISTIC REGRESSION | P=0.497 P=0.547 P=0.554 | P=0.124 P=0.018 * P=0.160 |
|COCHRAN-ARMITAGE | P=0.517 | P=0.156 |
|FISHER EXACT | P=0.506 P=0.560 | P=0.013 * P=0.196 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 4/50 (8%) | 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 21.2% 5.4% 20.1% | 3.2% 0.0% 4.2% |
|TERMINAL (d) | 1/14 (7%) 0/22 (0%) 3/17 (18%) | 0/23 (0%) 0/20 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 706 631 630 | 679 --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.550N P=0.243N P=0.586N | P=0.651N P=0.494N P=0.745N |
|INCIDENTAL TUMOR | P=0.527 P=0.390N P=0.602 | P=0.665N P=0.435N P=0.756N |
|LOGISTIC REGRESSION | P=0.576 P=0.306N P=0.647 | P=0.668N P=0.499N P=0.761N |
|COCHRAN-ARMITAGE | P=0.579 | P=0.669N |
|FISHER EXACT | P=0.339N P=0.643N | P=0.500N P=0.753N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 7.7% 2.1% | 0.0% 0.0% 3.4% |
|TERMINAL (d) | 0/14 (0%) 1/22 (5%) 0/17 (0%) | 0/23 (0%) 0/20 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 700 493 | --- --- 700 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.367 P=0.316 P=0.513 | P=0.282 (e) P=0.514 |
|INCIDENTAL TUMOR | P=0.411 P=0.227 P=0.638 | P=0.258 (e) P=0.500 |
|LOGISTIC REGRESSION | P=0.361 P=0.272 P=0.486 | P=0.268 (e) P=0.500 |
|COCHRAN-ARMITAGE | P=0.360 | P=0.269 |
|FISHER EXACT | P=0.247 P=0.500 | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 6/50 (12%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 21.2% 12.7% 24.7% | 3.2% 0.0% 7.5% |
|TERMINAL (d) | 1/14 (7%) 1/22 (5%) 3/17 (18%) | 0/23 (0%) 0/20 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 706 631 493 | 679 --- 700 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.333 P=0.497N P=0.433 | P=0.382 P=0.494N P=0.524 |
|INCIDENTAL TUMOR | P=0.265 P=0.593 P=0.346 | P=0.361 P=0.435N P=0.505 |
|LOGISTIC REGRESSION | P=0.296 P=0.599N P=0.362 | P=0.361 P=0.499N P=0.502 |
|COCHRAN-ARMITAGE | P=0.303 | P=0.360 |
|FISHER EXACT | P=0.643N P=0.370 | P=0.500N P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.0% 4.4% 5.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 1/17 (6%) | 0/23 (0%) 0/20 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 318 540 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.622 P=0.505 P=0.739N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.549N P=0.463 P=0.739N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.613 P=0.444 P=0.759 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.622N | (e) |
|FISHER EXACT | P=0.500 P=0.753N | (e) (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.3% 4.4% 11.8% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/22 (0%) 2/17 (12%) | 0/23 (0%) 0/20 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 318 540 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.598N P=0.673N P=0.667N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.560N P=0.618 P=0.691 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.599 P=0.655 P=0.695N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.601 | (e) |
|FISHER EXACT | P=0.691N P=0.691N | (e) (e) |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 31/50 (62%) 27/50 (54%) | |
|ADJUSTED (b) | 89.3% 85.4% 92.3% | |
|TERMINAL (d) | 11/14 (79%) 17/22 (77%) 15/17 (88%) | |
|FIRST INCIDENCE (DAYS) | 577 505 444 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.255N P=0.182N P=0.281N | |
|INCIDENTAL TUMOR | P=0.451N P=0.555 P=0.515N | |
|LOGISTIC REGRESSION | P=0.406N P=0.558 P=0.452N | |
|COCHRAN-ARMITAGE | P=0.381N | |
|FISHER EXACT | P=0.419 P=0.420N | |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/45 (11%) 5/46 (11%) 2/48 (4%) | 2/47 (4%) 3/30 (10%) 6/45 (13%) |
|ADJUSTED (b) | 25.7% 18.1% 11.8% | 8.7% 100.0% 21.6% |
|TERMINAL (d) | 3/14 (21%) 3/21 (14%) 2/17 (12%) | 2/23 (9%) 1/1 (100%) 3/24 (13%) |
|FIRST INCIDENCE (DAYS) | 602 559 735 (T) | 735 (T) 626 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139N P=0.471N P=0.171N | P=0.128 P=0.045 * P=0.151 |
|INCIDENTAL TUMOR | P=0.144N P=0.478N P=0.185N | P=0.078 P=0.049 * P=0.100 |
|LOGISTIC REGRESSION | P=0.165N P=0.614N P=0.210N | P=0.092 P=0.190 P=0.122 |
|COCHRAN-ARMITAGE | P=0.154N | P=0.090 |
|FISHER EXACT | P=0.616N P=0.192N | P=0.295 P=0.120 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/45 (4%) 1/46 (2%) 1/48 (2%) | 0/47 (0%) 0/30 (0%) 0/45 (0%) |
|ADJUSTED (b) | 4.7% 4.0% 5.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 0/21 (0%) 1/17 (6%) | 0/23 (0%) 0/1 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 577 716 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.381N P=0.482N P=0.510N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.413N P=0.531N P=0.502N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.353N P=0.509N P=0.464N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.358N | (e) |
|FISHER EXACT | P=0.492N P=0.476N | (e) (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/45 (13%) 6/46 (13%) 3/48 (6%) | 2/47 (4%) 3/30 (10%) 6/45 (13%) |
|ADJUSTED (b) | 27.4% 21.4% 17.6% | 8.7% 100.0% 21.6% |
|TERMINAL (d) | 3/14 (21%) 3/21 (14%) 3/17 (18%) | 2/23 (9%) 1/1 (100%) 3/24 (13%) |
|FIRST INCIDENCE (DAYS) | 577 559 735 (T) | 735 (T) 626 687 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.164N P=0.462N P=0.196N | P=0.128 P=0.045 * P=0.151 |
|INCIDENTAL TUMOR | P=0.181N P=0.507N P=0.206N | P=0.078 P=0.049 * P=0.100 |
|LOGISTIC REGRESSION | P=0.185N P=0.606N P=0.232N | P=0.092 P=0.190 P=0.122 |
|COCHRAN-ARMITAGE | P=0.173N | P=0.090 |
|FISHER EXACT | P=0.605N P=0.211N | P=0.295 P=0.120 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/45 (0%) 2/46 (4%) 1/48 (2%) | 2/47 (4%) 0/30 (0%) 0/45 (0%) |
|ADJUSTED (b) | 0.0% 9.5% 5.9% | 6.3% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 2/21 (10%) 1/17 (6%) | 1/23 (4%) 0/1 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) 735 (T) | 533 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.401 P=0.330 P=0.539 | P=0.123N P=0.465N P=0.250N |
|INCIDENTAL TUMOR | P=0.401 P=0.330 P=0.539 | P=0.038N* P=0.469N P=0.077N |
|LOGISTIC REGRESSION | P=0.401 P=0.330 P=0.539 | P=0.086N P=0.279N P=0.205N |
|COCHRAN-ARMITAGE | P=0.378 | P=0.114N |
|FISHER EXACT | P=0.253 P=0.516 | P=0.369N P=0.258N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/45 (2%) 2/46 (4%) 1/48 (2%) | 2/47 (4%) 0/30 (0%) 0/45 (0%) |
|ADJUSTED (b) | 2.4% 9.5% 5.9% | 6.3% 0.0% 0.0% |
|TERMINAL (d) | 0/14 (0%) 2/21 (10%) 1/17 (6%) | 1/23 (4%) 0/1 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 602 735 (T) 735 (T) | 533 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595N P=0.588 P=0.754N | P=0.123N P=0.465N P=0.250N |
|INCIDENTAL TUMOR | P=0.593N P=0.614 P=0.751N | P=0.038N* P=0.469N P=0.077N |
|LOGISTIC REGRESSION | P=0.619N P=0.513 P=0.751N | P=0.086N P=0.279N P=0.205N |
|COCHRAN-ARMITAGE | P=0.601N | P=0.114N |
|FISHER EXACT | P=0.508 P=0.736N | P=0.369N P=0.258N |
|=================================================================================================================================|
| |
|Uterus |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | | 8.2% 0.0% 0.0% |
|TERMINAL (d) | | 1/23 (4%) 0/20 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | | 731 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.100N P=0.270N P=0.235N |
|INCIDENTAL TUMOR | | P=0.091N P=0.218N P=0.235N |
|LOGISTIC REGRESSION | | P=0.094N P=0.255N P=0.228N |
|COCHRAN-ARMITAGE | | P=0.095N |
|FISHER EXACT | | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 6/50 (12%) 6/50 (12%) 5/50 (10%) |
|ADJUSTED (b) | | 16.2% 16.3% 17.8% |
|TERMINAL (d) | | 1/23 (4%) 1/20 (5%) 3/24 (13%) |
|FIRST INCIDENCE (DAYS) | | 573 560 666 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.425N P=0.588N P=0.476N |
|INCIDENTAL TUMOR | | P=0.503 P=0.583N P=0.622 |
|LOGISTIC REGRESSION | | P=0.533 P=0.556 P=0.500N |
|COCHRAN-ARMITAGE | | P=0.437N |
|FISHER EXACT | | P=0.620N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 6/50 (12%) 7/50 (14%) 6/50 (12%) |
|ADJUSTED (b) | | 16.2% 18.1% 19.8% |
|TERMINAL (d) | | 1/23 (4%) 1/20 (5%) 3/24 (13%) |
|FIRST INCIDENCE (DAYS) | | 573 560 575 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.544N P=0.538 P=0.598N |
|INCIDENTAL TUMOR | | P=0.321 P=0.543 P=0.448 |
|LOGISTIC REGRESSION | | P=0.360 P=0.420 P=0.445 |
|COCHRAN-ARMITAGE | | P=0.560N |
|FISHER EXACT | | P=0.500 P=0.620N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 26/50 (52%) 27/50 (54%) | 27/50 (54%) 23/50 (46%) 20/50 (40%) |
|ADJUSTED (b) | 83.2% 65.1% 80.3% | 72.4% 57.0% 53.8% |
|TERMINAL (d) | 9/14 (64%) 9/22 (41%) 11/17 (65%) | 13/23 (57%) 5/20 (25%) 8/24 (33%) |
|FIRST INCIDENCE (DAYS) | 447 540 540 | 577 519 505 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.323N P=0.102N P=0.329N | P=0.120N P=0.360N P=0.128N |
|INCIDENTAL TUMOR | P=0.498 P=0.403N P=0.572 | P=0.071N P=0.153N P=0.077N |
|LOGISTIC REGRESSION | P=0.390N P=0.297N P=0.435N | P=0.096N P=0.143N P=0.114N |
|COCHRAN-ARMITAGE | P=0.382N | P=0.096N |
|FISHER EXACT | P=0.344N P=0.420N | P=0.274N P=0.115N |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 14.3% 11.3% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/14 (14%) 1/22 (5%) 0/17 (0%) | 0/23 (0%) 0/20 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 735 (T) 702 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.172N P=0.655 P=0.194N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.219N P=0.531 P=0.194N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.188N P=0.590 P=0.194N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.202N | (e) |
|FISHER EXACT | P=0.500 P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 44/50 (88%) 48/50 (96%) 48/50 (96%) | 39/50 (78%) 47/50 (94%) 43/50 (86%) |
|ADJUSTED (b) | 97.8% 100.0% 100.0% | 88.2% 97.9% 100.0% |
|TERMINAL (d) | 13/14 (93%) 22/22 (100%) 17/17 (100%) | 18/23 (78%) 19/20 (95%) 24/24 (100%) |
|FIRST INCIDENCE (DAYS) | 318 449 444 | 533 553 490 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.434 P=0.205N P=0.469 | P=0.396 P=0.125 P=0.411 |
|INCIDENTAL TUMOR | P=0.030 * P=0.163 P=0.054 | P=0.026 * P=0.050 P=0.064 |
|LOGISTIC REGRESSION | P=0.074 P=0.186 P=0.122 | P=0.027 * P=0.038 * P=0.155 |
|COCHRAN-ARMITAGE | P=0.080 | P=0.157 |
|FISHER EXACT | P=0.134 P=0.134 | P=0.020 * P=0.218 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 34/50 (68%) 35/50 (70%) 30/50 (60%) | 32/50 (64%) 26/50 (52%) 29/50 (58%) |
|ADJUSTED (b) | 88.3% 82.7% 81.7% | 77.4% 61.5% 71.6% |
|TERMINAL (d) | 10/14 (71%) 15/22 (68%) 11/17 (65%) | 14/23 (61%) 5/20 (25%) 13/24 (54%) |
|FIRST INCIDENCE (DAYS) | 447 261 444 | 533 519 258 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.228N P=0.188N P=0.252N | P=0.304N P=0.266N P=0.325N |
|INCIDENTAL TUMOR | P=0.385N P=0.523 P=0.410N | P=0.292N P=0.068N P=0.320N |
|LOGISTIC REGRESSION | P=0.232N P=0.550 P=0.268N | P=0.306N P=0.080N P=0.343N |
|COCHRAN-ARMITAGE | P=0.230N | P=0.306N |
|FISHER EXACT | P=0.500 P=0.266N | P=0.156N P=0.341N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05097 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- ALPHA-CHLOROACETOPHENONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 1 MG/M3 2 MG/M3 | CONTROL 1 MG/M3 2 MG/M3 |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 48/50 (96%) 50/50 (100%) 49/50 (98%) | 45/50 (90%) 50/50 (100%) 48/50 (96%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 93.8% 100.0% 100.0% |
|TERMINAL (d) | 14/14 (100%) 22/22 (100%) 17/17 (100%) | 20/23 (87%) 20/20 (100%) 24/24 (100%) |
|FIRST INCIDENCE (DAYS) | 318 261 444 | 533 519 258 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.458N P=0.137N P=0.474N | P=0.452 P=0.235 P=0.469 |
|INCIDENTAL TUMOR | P=0.233 P=0.347 P=0.341 | P=0.029 * P=0.102 P=0.055 |
|LOGISTIC REGRESSION | P=0.389 P=0.236 P=0.608 | P=0.113 P=0.063 P=0.202 |
|COCHRAN-ARMITAGE | P=0.360 | P=0.118 |
|FISHER EXACT | P=0.247 P=0.500 | P=0.028 * P=0.218 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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