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TDMS Study 05097-01 Pathology Tables

NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48




       Facility:  Battelle Northwest

       Chemical CAS #:  532-27-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|             
                                           | 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Anus, Parasite Metazoan              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  A|             
      Parasite Metazoan                    | X                                         X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X              X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  1     1     1  2  2     1  2  3  2  3  2           1     1  1     1  1|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  |                1                             2           2               |             
      Hematopoietic Cell Proliferation     |             2           1                             1     1        1   |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |          X                       X     X                                 |             
      Inflammation, Focal, Granulomatous   | 2  1     1        1  2  2  2  1     2     1           1     1        1  1|             
      Leukocytosis                         |                               2                                          |             
      Necrosis                             |       2  1                       1     1           2              2      |             
      Bile Duct, Hyperplasia               |       2  1     2                 2                 2        1            |             
      Hepatocyte, Hyperplasia              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +  +                                                            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal, Suppurative          |          3                                                               |             
      Fat, Inflammation, Chronic           |       3                                                                  |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     1                                    |             
      Acinus, Atrophy                      |       3     2        1     2        2                                    |             
      Acinus, Cytomegaly                   |                         1              1                                 |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Duct, Hyperplasia                    |       1                 1           1                 1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|             
                                           | 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
      Inflammation, Chronic, Suppurative   |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1     2        1  2  2  2  3  1  2  2  2  2     1  1     1  2     1  2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2        1     2  1  3  2              1        2  2        3         |             
      Focal Cellular Change                |             2                       2  1                                 |             
      Hematopoietic Cell Proliferation     |             1        1                                2              2   |             
      Hyperplasia                          | 2        1                          2                             4     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hyperplasia                          |    2  2  1        3     2        2     2     1                 2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Angiectasis           |                                                    3                     |             
      Pars Distalis, Cyst                  |                                                          1               |             
      Pars Distalis, Degeneration, Cystic  |                3                                                         |             
      Pars Distalis, Hyperplasia           |             1        1           2     3           2  2                  |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Mixed Cell                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  A|             
      Cyst                                 |                                                                X         |             
      C-Cell, Hyperplasia                  |       2        3  2  2  4     1  1  2        2     2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  M  +  +  +  M  +|             
      Cyst                                 |                         X                 X                              |             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Chronic                |                                     4                                    |             
      Inflammation, Suppurative            |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|             
                                           | 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Hyperplasia                    |                                     4                                    |             
      Duct, Inflammation, Suppurative      |                1                                                         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3  3        3  3     3              3                              |             
      Cyst                                 |                            X              X        X  X                  |             
      Interstitium, Hyperplasia            |                            3                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Cyst, Multiple          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Myelofibrosis                        |          2                                1                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Axillary, Hematopoietic Cell         |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  A  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  M|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    2  2  2        2     2           2                    4  2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         1                                                |             
      Hematopoietic Cell Proliferation     |             3           2                             1              2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  M  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Galactocele                          |       1        2        1  2                       1                     |             
      Hyperplasia                          |                2                                               1  1      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                4         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     2                                    |             
      Inflammation, Suppurative            |                                                                1         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|             
                                           | 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Suppurative   |                                                          3               |             
      Osteopetrosis                        |          2              2                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Pigmentation, Hemosiderin            |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation                         |                2                                                         |             
      Inflammation, Suppurative            |          1           2                       1        1        2         |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         4|             
      Hemorrhage                           |                                  2                 2              1      |             
      Infiltration Cellular, Mixed Cell    |             3                                                            |             
      Inflammation, Chronic, Focal         |       1  2                                         2                     |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          1     1                 1                 3              2      |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                         2           1                       1        1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Foreign Body                         |       1                 1                                                |             
      Inflammation                         | 1  1  2  1        1  2  2  2     1  2  1  2        1  1     1  1     2   |             
      Inflammation, Suppurative            |    1  2     1        1     1  1     1  1           1  1  4  1  1     1   |             
      Thrombosis                           |       2                          2                                2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                         2                                            2   |             
      Olfactory Epithelium, Degeneration   |                      1  1                                                |             
      Olfactory Epithelium, Metaplasia     |    1  2                 1                                      2         |             
      Respiratory Epithelium, Hyperplasia  |       2  1           1           1  1  1           1  1  3        1      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                          1               |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |    1                             1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|             
      Inflammation                         |          2                    1                                          |             
      Inflammation, Suppurative            |    1                                                        1            |             
      Epithelium, Hyperplasia              |                               2                                      2   |             
      Epithelium, Metaplasia, Squamous     |          1                    3  1                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|             
                                           | 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Synechia                             |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Lens, Degeneration                   |                                     1                                    |             
      Lens, Mineralization                 |                                                                          |             
      Retina, Atrophy                      |    1                                1                    1               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +     +     +                    +     +                              |             
      Inflammation                         |                                     2                                    |             
      Inflammation, Suppurative            |          1     1                                                         |             
      Metaplasia, Squamous                 |    1                                      1                              |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +                                   +              +                  |             
      Acinus, Atrophy                      |    2                                   1              2                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Hematopoietic Cell Proliferation     |             1                                                            |             
      Nephropathy                          | 1  3  1  3  1  1  3  1  2  2  2  1  1  1  3  2     2  1     3  2  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7|            |
                                           | 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Anus, Parasite Metazoan              |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                                          X               |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Parasite Metazoan                    |                                              X                           |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                   2  2                                      2  2         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | 2  1        1     2  1     2  1        2  1     1     1     2  1     1   |     31  1.5|
      Clear Cell Focus                     |                               1                                          |      1  1.0|
      Degeneration, Fatty                  |       2              1  2           4  2              3  3     1  3     3|     13  2.2|
      Hematopoietic Cell Proliferation     |             1              1                                             |      7  1.1|
      Hemorrhage                           |                                                    4                     |      1  4.0|
      Hepatodiaphragmatic Nodule           | X                                                  X                     |      5     |
      Inflammation, Focal, Granulomatous   |    2        2  1  2  2     2  1  1     2  1                 2        2   |     26  1.5|
      Leukocytosis                         |                                                                          |      1  2.0|
      Necrosis                             |                                                    3                     |      7  1.7|
      Bile Duct, Hyperplasia               |       2  1     1     1           1  1        1  2  1              1     1|     17  1.4|
      Hepatocyte, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +                                      +                     |   6        |
      Hemorrhage                           |             3                                                            |      1  3.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal, Suppurative          |                                                                          |      1  3.0|
      Fat, Inflammation, Chronic           |       3                                                                  |      2  3.0|
      Fat, Necrosis                        |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         | 1  1           1                                                         |      4  1.0|
      Acinus, Atrophy                      | 1  1  1        2  1  3        3     1              1           1         |     15  1.7|
      Acinus, Cytomegaly                   |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                            +                                             |   1        |
      Palate, Inflammation, Chronic        |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7|            |
                                           | 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Hyperplasia                    |       1     2        1     1        1        1           1        1  1  2|     14  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Hyperplasia, Squamous                |                         3                                         4      |      2  3.5|
      Inflammation                         |                                                                   2      |      1  2.0|
      Ulcer                                |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Chronic, Suppurative   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                | 2  3     1  1     2  1  1  2  2  1  2  1  3  2        1  1  1        1  2|     38  1.6|
      Atrium, Thrombosis                   |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  | 2                 1  1  2        1  2  2  1  2  2           1     2      |     22  1.7|
      Focal Cellular Change                | 2  2                    1                       1                       2|      8  1.6|
      Hematopoietic Cell Proliferation     |                                     1                                    |      5  1.4|
      Hyperplasia                          |                            2        2                 2  2        2      |     10  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |          2                             3  1  2     2     3               |     15  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  M  M  +  +  +  M  +  +  +  M  +  +  M  +  M  M  +|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                2         |      1  2.0|
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Degeneration, Cystic  |          3                                3                              |      3  3.0|
      Pars Distalis, Hyperplasia           |          2           2        3  1  4                 2     3            |     13  2.2|
      Pars Distalis, Infiltration Cellular,|                                                                          |            |
           Mixed Cell                      |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 3     1     1  2  2  1     3     1           2     2     3  2  2  3      |     24  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7|            |
                                           | 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                          |      2     |
      Hyperplasia                          | 3                                                                        |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            | 2     2     4                                   2           2            |      6  2.2|
      Duct, Hyperplasia                    |                               3                                          |      2  3.5|
      Duct, Inflammation, Suppurative      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |       3                                      3                           |      8  3.0|
      Cyst                                 |                X                                               X         |      6     |
      Interstitium, Hyperplasia            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                    3                     |      1  3.0|
      Endometrium, Cyst, Multiple          |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Cellular                   | 2                                                                        |      1  2.0|
      Myelofibrosis                        |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Axillary, Hematopoietic Cell         |                                                                          |            |
          Proliferation                    |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia                          |                                                                      2   |      1  2.0|
      Inflammation, Granulomatous          |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hematopoietic Cell Proliferation     |                                                    2                     |      1  2.0|
      Hyperplasia                          |                   2  2     2        2        2        2                 2|     15  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |          1                                                               |      2  1.0|
      Hematopoietic Cell Proliferation     |                            2                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +|  38        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7|            |
                                           | 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Galactocele                          | 1              2  2  1                                   1               |     10  1.4|
      Hyperplasia                          |             1                                                        2  1|      6  1.3|
      Inflammation, Chronic                |                                                 3                        |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                               2                 3                        |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fracture                             |                                        X                                 |      1     |
      Inflammation, Chronic, Suppurative   |                                                                          |      1  3.0|
      Osteopetrosis                        |                                                       2                  |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |                                                    2                     |      2  2.0|
      Inflammation, Suppurative            |    1  2  1  1  1              1        2     1           1  1     1  1  1|     18  1.2|
      Metaplasia, Squamous                 |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage                           |                                     1                                    |      4  1.5|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 1                                                                    1   |      5  1.4|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                      3   |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       1  2     1              1           1              1               |     11  1.4|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |    1        1     1  1     1  1     1  1  1                    1         |     14  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                     1                                    |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7|            |
                                           | 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         | 1  2  1  2  1  1  1  1     1  2  1  1  1  2  1  1  1  1  1  2  1  1  2  3|     41  1.4|
      Inflammation, Suppurative            | 1  1  1              1     1  1     1  1     1  1  1     1  1  1        3|     29  1.2|
      Thrombosis                           |       2                             1                 2                 2|      7  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             2                       1        2     2     1               |      7  1.7|
      Olfactory Epithelium, Degeneration   |                                                                          |      2  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      4  1.5|
      Respiratory Epithelium, Hyperplasia  | 1     1                       1  1        1  1           1     1     1  1|     20  1.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |    2                 1                       1                 1         |      6  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation                         |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                                     1                                    |      3  1.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
      Epithelium, Metaplasia, Squamous     |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Synechia                             |                                        3                                 |      1  3.0|
      Cornea, Inflammation, Suppurative    |                                        1                                 |      1  1.0|
      Lens, Degeneration                   |                                        3                             1   |      3  1.7|
      Lens, Mineralization                 |                                        3                                 |      1  3.0|
      Retina, Atrophy                      |                                  1     4                             1   |      6  1.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   5        |
      Inflammation                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Metaplasia, Squamous                 |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   3        |
      Acinus, Atrophy                      |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Nephropathy                          | 2  2  2  2  2  3  2  3  2  3  2  2  2  4  2  2  3  1  2  1  2  3  2  3  2|     48  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|             
                                           | 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     I  +  +        +  +     +     +     +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +        +  +     +     A     +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A     +  +  +        +  +     +     A     +  +           +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +        +  +     +     A     M  +           +  +   |             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +        +  +     +     A     +  M           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A     +  +  +        +  +     +     +     +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A     +  +  +        +  +     +     +     +  +           +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A     +  +  +        +  +     +     A     +  +           +  +   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A     +  +  +        +  +     +     A     +  +           +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +     +  +  +  +  +     +  +  +  +        +  +  +   |             
      Angiectasis                          |    1  3                                      1                           |             
      Basophilic Focus                     |    X  1        2     1     1  1  1  2        1     1              1      |             
      Degeneration, Fatty                  | 2              1                       2              2        1     3   |             
      Eosinophilic Focus                   |                                                                   3      |             
      Hematopoietic Cell Proliferation     |                                                                   1      |             
      Hepatodiaphragmatic Nodule           |                            X     X  X                                    |             
      Inflammation, Focal, Granulomatous   |    2  2        3  1  2     1  1  1  1        2                 1  2      |             
      Necrosis                             |                                                    1                     |             
      Bile Duct, Hyperplasia               | 1                                      2              2                  |             
      Hepatocyte, Hyperplasia, Focal       |                                                                3         |             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                +   |             
      Fat, Inflammation, Chronic           |                                     3                                    |             
      Fat, Necrosis                        |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +        +  +     +     +     +  +           +  +   |             
      Acinus, Atrophy                      |                1                       2                          1      |             
      Acinus, Cytomegaly                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +        +  +     +           +  +           +  +   |             
      Inflammation, Suppurative            |                               1                                          |             
      Duct, Hyperplasia                    |    1                          1        1              1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                3  2      |             
      Inflammation                         |                                                                2  1      |             
      Ulcer                                |                                                                1         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|             
                                           | 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +        +  +     +     +     +  +           +  +   |             
      Inflammation, Chronic                |          3     2                       1     2     1  1           2  1   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2  1     2  1  1  1  2     1  1  2              1           2  1  2  2|             
      Degeneration                         |                                                 2                        |             
      Focal Cellular Change                |             1              1                                             |             
      Hematopoietic Cell Proliferation     | 1  1                                      1                              |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                                    1                     |             
      Bilateral, Hypertrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2           3                    1                             3     3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +     +     +     +  +           +  M   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  I  +  M     M  M  +        +  M     +     +     +  +           +  M   |             
      Hyperplasia                          |                                                       4                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |                                     3                 3  3               |             
      Pars Distalis, Mineralization        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +        +  +     +     +     +  +           +  +   |             
      C-Cell, Hyperplasia                  |                   1  1                             1              1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  I        +  +     +     +     +  +        M  +  +   |             
      Hyperplasia                          |                                  2                                       |             
      Inflammation, Suppurative            |                2              1        2              1           3  2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +        +  +  +  +     +     +  +           +      |             
      Atrophy                              |                                  2                    2                  |             
      Cyst                                 |       1     3     1                 X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +     +  +     +  +  +     +  +           +  +   |             
      Dilatation                           |                                           2                              |             
      Prolapse                             |                         X                                                |             
      Endometrium, Cyst, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|             
                                           | 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +        +  +     +     +     +  +           +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +     +  +     +     +     +  +           +  +   |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +     M  M  +  +     +  M     +     +     +  +           +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +        +  +     +     +     +  +           +  +   |             
      Hyperplasia                          |       2        2  2           2  3                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +        +  +  +  +     +  +  +  +           +  +   |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +     +  +  +        +  M     +     +     +  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |       1     1                                         1                 1|             
      Hyperplasia                          | 2              2     2                                                   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +        +        M           +  +           +  +   |             
      Inflammation, Suppurative            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
      Subcutaneous Tissue, Thrombosis      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +        +  +     +     +     +  +           +  +   |             
      Fibrous Osteodystrophy               |                                                                          |             
      Osteopetrosis                        | 2                                      2           3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +        +  +     +     +     +  +           +  +   |             
      Hemorrhage                           |          1                                         1                     |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +     +  +  +        +  +     +     I     +  +           +  +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +     +  +     +     +  +  +  +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|             
                                           | 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |          2     1                                                  1  1   |             
      Inflammation, Chronic, Focal         | 1                                      1                             1   |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         1                                         3     2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1                                      1                           |             
      Mediastinum, Inflammation,           |                                                                          |             
          Granulomatous                    |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |    1           1     1  2                                1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 1                                                                        |             
      Inflammation                         | 1  2  2  1  2  3  1     1  3  2  2  2     2  1  1     1  3     2  1     1|             
      Inflammation, Suppurative            | 1        1     2              1                 1  1  1     1     1      |             
      Thrombosis                           |                                        2                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          1     2     1              2              1  2           1      |             
      Olfactory Epithelium, Metaplasia     | 2           1                                                            |             
      Respiratory Epithelium, Hyperplasia  | 2     1  2  2  1        1  2  1     1        1  1     1        2     1  1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                1                             1                       3   |             
      Respiratory Epithelium, Ulcer        |                                                                          |             
      Vomeronasal Organ, Inflammation      | 1     1                                                                  |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |          1                                   1                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +        +  +     +     I     +  +           +  +   |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |                                                                      1   |             
      Epithelium, Metaplasia, Squamous     |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Synechia                             |                                                                          |             
      Lens, Degeneration                   |                                                                          |             
      Lens, Mineralization                 |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Inflammation, Suppurative            |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                +        +|             
      Acinus, Atrophy                      |                                                                2        2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +     +  +     +     +     +  +        +  +  +   |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|             
                                           | 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 1  2  2  2     2  2  2  2     2  3     2     1     2  2        4  2  2   |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +        +  +     +  +  +     +  +           +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3|            |
                                           | 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  28        |
      Parasite Metazoan                    |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  28        |
      Parasite Metazoan                    |                                           X                             X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +        +  +        +  +  +              +  M     +  +  +|  27        |
      Hyperplasia, Lymphoid                |                2                                                  2      |      2  2.0|
      Parasite Metazoan                    |                                                          X               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +|  41        |
      Angiectasis                          |                                                    1                     |      4  1.5|
      Basophilic Focus                     | 2  2  1  1     1     1           2              2  1  1  2  1     1     1|     25  1.3|
      Degeneration, Fatty                  |    2        1  1           3        3  2                          2      |     13  1.9|
      Eosinophilic Focus                   |                2                                                         |      2  2.5|
      Hematopoietic Cell Proliferation     |                                           2                              |      2  1.5|
      Hepatodiaphragmatic Nodule           |                      X     X                    X                        |      6     |
      Inflammation, Focal, Granulomatous   |    2  1  1     2     1           1        1     1  1  1  1     1        1|     25  1.4|
      Necrosis                             |                         1                                                |      2  1.0|
      Bile Duct, Hyperplasia               | 1           1                       1  2                             1   |      8  1.4|
      Hepatocyte, Hyperplasia, Focal       |                                  3                                       |      2  3.0|
      Hepatocyte, Hyperplasia              |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Inflammation, Chronic           |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  30        |
      Acinus, Atrophy                      |             2                                                     1  2   |      6  1.5|
      Acinus, Cytomegaly                   |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  29        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Duct, Hyperplasia                    | 1           1                                                     1     2|      8  1.1|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |    3                    2  2                                            3|      6  2.5|
      Inflammation                         |    3                    2  2        1                                   2|      7  1.9|
      Ulcer                                |    3                       1                                            2|      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3|            |
                                           | 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                            3                                             |      1  3.0|
      Ulcer                                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +               |   1        |
      Inflammation, Suppurative            |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  30        |
      Inflammation, Chronic                | 2  1           1        1           1  2                          2  2   |     16  1.6|
      Atrium, Thrombosis                   |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  | 1  2           1  3     2  1        2  1  2  1     2  1     1  2         |     29  1.5|
      Degeneration                         |                   3                                                      |      2  2.5|
      Focal Cellular Change                |    1                          1                                   2      |      5  1.2|
      Hematopoietic Cell Proliferation     |                         1                 2     1  1                     |      7  1.1|
      Hyperplasia                          |                         2        2                                       |      2  2.0|
      Hypertrophy                          |                                                       3                  |      1  3.0|
      Necrosis                             |                                                                          |      1  1.0|
      Bilateral, Hypertrophy               |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                1  3           1        2                                1|     10  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     +  +  +        M  +        +  +  +              +  +     +  +  M|  22        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |      1  2.0|
      Pars Distalis, Hyperplasia           |             4                                               3            |      5  3.2|
      Pars Distalis, Mineralization        |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  30        |
      C-Cell, Hyperplasia                  | 2  1     1     2           1              1                       1  1  1|     14  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +     +  +        +  +  +  +  +  +     +  +     +  +  M|  33        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3|            |
                                           | 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          | 2                                                                 1      |      3  1.7|
      Inflammation, Suppurative            |       2     3  2                                2                        |     10  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  31        |
      Atrophy                              |                                                                      2   |      3  2.0|
      Cyst                                 |                                                                          |      4  1.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +  +        +  +  +     +  +  +              +  +     +  +  +|  33        |
      Dilatation                           |                                                                          |      1  2.0|
      Prolapse                             |                                                                          |      1     |
      Endometrium, Cyst, Multiple          |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                  +                                       |   1        |
      Hypertrophy                          |                                  3                                       |      1  3.0|
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  31        |
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +     M  +  +        +  +        +  +  +              M  +     +  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  30        |
      Hyperplasia                          |    2           2                          2                              |      8  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +     +  +        +  +  +        +     +  +     +  +  +|  35        |
      Fibrosis                             | 2                                                                        |      1  2.0|
      Hematopoietic Cell Proliferation     |                                           2                              |      1  2.0|
      Hyperplasia, Lymphoid                |                   2                                                      |      1  2.0|
      Inflammation, Focal, Granulomatous   |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +  +  +        M  +        +  I  +              +  +     +  M  +|  24        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |       1                                            2           1     1   |      8  1.1|
      Hyperplasia                          |          2        2           1                    3        3  1         |      9  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  27        |
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                             4            |      1  4.0|
      Subcutaneous Tissue, Necrosis        |                                                             4            |      1  4.0|
      Subcutaneous Tissue, Thrombosis      |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3|            |
                                           | 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  30        |
      Fibrous Osteodystrophy               |                                                                         2|      1  2.0|
      Osteopetrosis                        |                                                                   1      |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  30        |
      Hemorrhage                           |                                                                          |      2  1.0|
      Hydrocephalus                        |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +        +  +  +        +  +        +  +  +              +  I     +  +  +|  27        |
      Hyperplasia                          |                                           1                              |      1  1.0|
      Inflammation, Suppurative            |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +        +  +  +  +     +  +  +|  40        |
      Hemorrhage                           |          1  1                                               1            |      7  1.1|
      Inflammation, Chronic, Focal         | 2           1           1              1              1           1      |      9  1.1|
      Thrombosis                           |                            1                                             |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                               3                                          |      4  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      1     3        1                                2   |      6  1.5|
      Mediastinum, Inflammation,           |                                                                          |            |
          Granulomatous                    |                                                    3                     |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                   1     1                 1        2     1               |     10  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  1.0|
      Inflammation                         | 3  1  1  1     1  2  2     2  2  2     1  1  2  2  1  1  1     3  1  1  2|     41  1.6|
      Inflammation, Suppurative            | 2  1  1  1        1  1     2  1  1  1  1  1  1  1     1        1  1  1   |     27  1.1|
      Thrombosis                           |                            1                                             |      2  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |          1                                   2        2           1      |     11  1.5|
      Olfactory Epithelium, Metaplasia     |                      1                                                   |      3  1.3|
      Respiratory Epithelium, Hyperplasia  | 3        1        2  2  1  1  3  1     2     1  1  1  1     1  3     1   |     31  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2                          1                                2        1   |      7  1.6|
      Respiratory Epithelium, Ulcer        |                            3                                             |      1  3.0|
      Vomeronasal Organ, Inflammation      |                                                                          |      2  1.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7|            |
                             DAY ON TEST   | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3|            |
                                           | 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Suppurative                     |                            1                                             |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  29        |
      Inflammation, Suppurative            |                            1                                            1|      2  1.0|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
      Epithelium, Metaplasia, Squamous     | 1                                                                        |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   2        |
      Synechia                             |                                                       4                  |      1  4.0|
      Lens, Degeneration                   |                                                       3                  |      1  3.0|
      Lens, Mineralization                 |                                                       2                  |      1  2.0|
      Retina, Atrophy                      |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   2        |
      Inflammation, Suppurative            |          2                                                               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                     +                                    |   3        |
      Acinus, Atrophy                      |                                     1                                    |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +     +  +  +  +  +  +  +        +     +  +  +  +  +  +|  37        |
      Cyst                                 |                                        2                                 |      1  2.0|
      Nephropathy                          | 2  3     2  2  2  2     1  2  2  3  2  2  2        2     1  2  3  2  1  4|     37  2.1|
      Renal Tubule, Hyperplasia            |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +        +  +        +  +  +              +  +     +  +  +|  31        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|             
                                           | 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  I  +  +  +  +  A  M  +  +  +  +  +  +  A  +  +  M  +  +  +  +  M  +|             
      Inflammation                         |                   3                                                      |             
      Parasite Metazoan                    |                                        X                    X     X      |             
      Ulcer                                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                  X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                             2  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Basophilic Focus                     | 1  1     2        1  1        1  1  2  1  1  1     1  1  2  1  3     1  2|             
      Degeneration, Fatty                  |                3  2        1                    2     1                  |             
      Hematopoietic Cell Proliferation     |                   2           2                          1               |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Inflammation, Focal, Granulomatous   | 1     3  2     1              1  2  1     1  2        1  2        1     3|             
      Leukocytosis                         |                                  2           2                 2         |             
      Necrosis                             |             1                                      1                    1|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Bile Duct, Hyperplasia               |             1        1                 1           1     1              2|             
      Hepatocyte, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Fat, Inflammation, Chronic           |                            1                                             |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           1                              |             
      Acinus, Atrophy                      |       3        1        1                    2     2                    2|             
      Acinus, Cytomegaly                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1                 1                                      1|             
      Duct, Hyperplasia                    |       1  1     2              1  2        1  1     1     1              1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       2        3  2     2  3                             2               |             
      Inflammation                         |       1        3  2     2  1                             4               |             
      Ulcer                                |                1  2     2                                4               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|             
                                           | 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                 2        1               |             
      Mineralization                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +                                                                  |             
      Inflammation                         |       2                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2     2  1  3  2  1  2  1     1     2  2  2  2           2     2  2     2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Degeneration, Fatty                  | 1     2  1     2                    2  2           3     1  2  2  2     1|             
      Degeneration                         |                            3                                             |             
      Focal Cellular Change                |          1                                3                              |             
      Hematopoietic Cell Proliferation     |             1     2                    2  1     1           1            |             
      Hyperplasia                          |       3     2                       1  2                          2     2|             
      Hypertrophy                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |          1  2  1                    2              2              2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |             1  2                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Degeneration, Cystic  |                                                                      2   |             
      Pars Distalis, Hyperplasia           |                                                    2                 2  2|             
      Pars Intermedia, Hyperplasia         |             3                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     2     4     2           3  4  3     2                 2            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic                |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|             
                                           | 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |          2                    1                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            3                 3           2               |             
      Cyst                                 |             X                                                            |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Cyst                    |                                                          X               |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous                    |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | I  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |    2           2                                                         |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       2                       2     2  2     2           2        2  3  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                         1|             
      Hematopoietic Cell Proliferation     |                   3                                      2               |             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Inflammation, Focal, Granulomatous   |          2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                  2                                       |             
      Hyperplasia                          |                         1     2  2        1                    2  1      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Suppurative            |    2                    2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|             
                                           | 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                              3  2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
      Inflammation, Suppurative            | 1                 1     1  1  2  2  1           1  2     1  2     1     1|             
      Metaplasia, Squamous                 |                               2                             1            |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        4                                 |             
      Infiltration Cellular, Mixed Cell    |                   1                                                      |             
      Inflammation, Chronic, Diffuse       |                                        3                                 |             
      Inflammation, Chronic, Focal         |       2                                                           1      |             
      Metaplasia, Squamous                 |       1                                                                  |             
      Pigmentation, Hemosiderin            |                                        2                                 |             
      Alveolar Epithelium, Hyperplasia     |       2                          2  2                             1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1           2  1                       2           1              1      |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Bronchus, Mineralization             |                   2                                                      |             
      Bronchus, Epithelium, Hyperplasia    |                                                    2                     |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                | 2  2           2        1     1                                      2   |             
      Pleura, Hyperplasia                  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               1                                          |             
      Inflammation                         | 2     2  2  2  2  2        1  1  2  2  2  2  1  1  2     3  2  2  2     2|             
      Inflammation, Suppurative            | 1        1  1  1  3        1  1  1  1  1     1  1  1  1  1     1  1     1|             
      Thrombosis                           |             1                                      3                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             1  2                                         2               |             
      Olfactory Epithelium, Degeneration   |                                                 1                        |             
      Olfactory Epithelium, Metaplasia     |                                                 1                        |             
      Respiratory Epithelium, Hyperplasia  | 2     2  3  2  2  3     1  1     2  1  2  2  1     2     3  2  2  2  1  3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 3     1  1  2        2  1              2     1     4     2  1     1  2  2|             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                        1     1     1                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|             
                             DAY ON TEST   | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|             
                                           | 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Epithelium, Metaplasia, Squamous     |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Synechia                             |                                  3                                       |             
      Lens, Degeneration                   | 1                                4           2                           |             
      Lens, Mineralization                 |                                  2                                       |             
      Retina, Atrophy                      | 1                                4  1  1                                1|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                          +                       +              +     +|             
      Inflammation, Suppurative            | 1                          1                       1              1      |             
      Metaplasia, Squamous                 |                                                    1                    1|             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |             +                                                            |             
      Acinus, Atrophy                      |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    2                                                                     |             
      Nephropathy                          | 2     2  2  4  3  2  2  1  2  3  2  3  1  2  1  2  1  3  3  1  2  3  1  2|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3|            |
                                           | 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Inflammation                         |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                           X                              |      4     |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                        X                                 |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  A  +  +  +  +  +  +  +  I  M  +  +  +  +  +  M  +  +  +  +  +  +  +|  43        |
      Parasite Metazoan                    |                         X              X  X                              |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                                              2        2           2      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |    2                    1                                                |      3  1.7|
      Basophilic Focus                     | 1  2     2     1     2     1     1  1  1  2  1        1     2        1  1|     33  1.3|
      Degeneration, Fatty                  | 1                             3     1                    2     1         |     10  1.7|
      Hematopoietic Cell Proliferation     |                               2                                      1   |      5  1.6|
      Hepatodiaphragmatic Nodule           |             X                       X                          X         |      4     |
      Inflammation, Focal, Granulomatous   |          2                 1        2  1  2  2  1        2  2  1  2  2  2|     26  1.7|
      Leukocytosis                         |                                                                          |      3  2.0|
      Necrosis                             | 1                 1        2              1                              |      7  1.1|
      Pigmentation, Hemosiderin            | 2                                                                        |      1  2.0|
      Bile Duct, Hyperplasia               |                   1                       2  1     1           2  1     1|     13  1.2|
      Hepatocyte, Hyperplasia              |                                              2           2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                                          |   2        |
      Fat, Inflammation, Chronic           |                                                                          |      1  1.0|
      Fat, Necrosis                        |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation                         |                                                                   2      |      2  1.5|
      Acinus, Atrophy                      | 1  2              2              1  1  1                       2  2      |     14  1.6|
      Acinus, Cytomegaly                   |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                             1            |      4  1.0|
      Duct, Hyperplasia                    |                   1                 1  1  1     2     1     3        1  1|     19  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3|            |
                                           | 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                               2                                      4   |      8  2.5|
      Inflammation                         |                               2                                      4   |      8  2.4|
      Ulcer                                |                                                                      2   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                         +|   1        |
      Inflammation, Chronic                |                                                                         2|      1  2.0|
      Inflammation, Suppurative            |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                         +                                                |   2        |
      Inflammation                         |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    1     2  1  1  2  1  2  1     1  2  3  1  1  1  1  2  1  2     1     3|     37  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Degeneration, Cystic                 |                                                                         3|      1  3.0|
      Degeneration, Fatty                  | 1           2  1  2  1  2  2  3              1  3  2  2  1  1  1        1|     28  1.7|
      Degeneration                         |                                                                          |      1  3.0|
      Focal Cellular Change                |                                  2                                       |      3  2.0|
      Hematopoietic Cell Proliferation     |                      1                                1     1     1      |     10  1.2|
      Hyperplasia                          |                2  2  2  3                                            2   |     11  2.1|
      Hypertrophy                          |          2                                                               |      1  2.0|
      Inflammation, Chronic                |                                     1                                    |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                       1                  |      1  1.0|
      Hyperplasia                          | 2                 2        1  2                                2         |     11  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  M  +  +  +  M  +  +  +  M  +  M  M  +  M  +  +  +  +  +  +|  38        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Degeneration, Cystic  |                            3                                             |      2  2.5|
      Pars Distalis, Hyperplasia           |                            3  4        2                    4            |      7  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3|            |
                                           | 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  45        |
      C-Cell, Hyperplasia                  |    2     2     2  4  4  3                 2                 1  2  1  2  3|     21  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                      2                                1        1     1  1|      7  1.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                   2                                            2     2   |      6  2.3|
      Cyst                                 |                                                                          |      1     |
      Infiltration Cellular, Mixed Cell    |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                    +                     |   1        |
      Cyst                                 |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Endometrium, Cyst                    |                                                                          |      1     |
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | I  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Myelofibrosis                        |                                              1                    1      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mesenteric, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  A  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Hematopoietic Cell Proliferation     |                               1                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Granulomatous          |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  A  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hematopoietic Cell Proliferation     |                               2                                          |      1  2.0|
      Hyperplasia                          |          3     2              2  2  2                       2     2  3   |     17  2.2|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                      2   |      3  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3|            |
                                           | 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  A  +  M  +  +  M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |          1                                      1                        |      3  1.3|
      Hyperplasia                          |          1        1     1                       1                    1   |     11  1.3|
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        | 4                                      3           2                     |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                          3               |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                  1                                       |      2  1.0|
      Inflammation, Suppurative            |                   1     1  1  1  1        1     1           2  2         |     22  1.3|
      Metaplasia, Squamous                 |                                                                          |      2  1.5|
      Epithelium, Hyperplasia              |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  1.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |    1     1     3     1     1                 1           1               |      9  1.3|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            |                   2                                                      |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                3                             1                           |      6  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                3  2                    1  1     1                        |     11  1.5|
      Bronchiole, Epithelium, Hyperplasia  |                2                                                         |      1  2.0|
      Bronchus, Mineralization             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3|            |
                                           | 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchus, Epithelium, Hyperplasia    |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |          1                       1     2              1  1  1        1  1|     14  1.4|
      Pleura, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1  1.0|
      Inflammation                         | 1  2     2     1  2  1  2  2  2     1  1  2  2  2  1  2  2  2  1  3  1  3|     42  1.8|
      Inflammation, Suppurative            | 1  1     1     1        1  1  1  1     1        1  1  1        1  1  1   |     33  1.1|
      Thrombosis                           |                   2                                                      |      3  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    2                                   1                       1  1      |      7  1.4|
      Olfactory Epithelium, Degeneration   |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     | 2                 1                                                      |      3  1.3|
      Respiratory Epithelium, Hyperplasia  | 1  2     3     2  2  1     3  3     3     3  3  3     2  3  2  3  3     3|     38  2.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2  1     1        2           2     1     1     2        2  3     1     2|     26  1.7|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                              1                       1   |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |    1                       1  1                                          |      4  1.0|
      Epithelium, Metaplasia, Squamous     |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Synechia                             |    4                                                        3            |      3  3.3|
      Lens, Degeneration                   | 2  3                             1  1                       3            |      8  2.1|
      Lens, Mineralization                 | 1  3                                                        3            |      4  2.3|
      Retina, Atrophy                      | 3  4                             1                          4            |      9  2.2|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +           +  +                  |   8        |
      Inflammation, Suppurative            |                                        1              1                  |      6  1.0|
      Metaplasia, Squamous                 |                                                    1                     |      3  1.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |             2                                                            |      2  2.0|
      Nephropathy                          | 1  3     2  1  2  2  3  3  3  2  1  2  3  2  2  3  2  3  3  1  1  2  2  3|     48  2.1|
      Papilla, Necrosis                    |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7|            |
                             DAY ON TEST   | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3|            |
                                           | 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyperplasia            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |             3                                                            |      1  3.0|
      Transitional Epithelium, Hyperplasia |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|             
                                           | 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  A  +  M  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |       X        X                       X     X  X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Angiectasis                          |                               4                          1  1        2   |             
      Basophilic Focus                     |    1        1  1  1  1     1  1     2  2           2  1              2   |             
      Clear Cell Focus                     |                                     1                                    |             
      Congestion                           |                                                             4            |             
      Degeneration, Cystic                 |                2                                                         |             
      Degeneration, Fatty                  |                                  3        3                    4        2|             
      Eosinophilic Focus                   |                3                                                         |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Inflammation, Focal, Granulomatous   |             1     1  1     1  1                                      1   |             
      Necrosis                             |          3           1                                      1            |             
      Bile Duct, Hyperplasia               | 1     2  1        1  1  2  1     2  1  2  1     2  2                 1   |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Hepatocyte, Hyperplasia              |                   1           2                                      4   |             
      Hepatocyte, Necrosis                 |       1     1                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +                                 |             
      Fat, Inflammation, Chronic           |                                     3  2                                 |             
      Fat, Necrosis                        |                                     3  3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Acinus, Atrophy                      |       3           3  1     2        1  2        2                    1  1|             
      Acinus, Cytomegaly                   |                                                          2              1|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |    3                                                                     |             
      Inflammation                         |                               1        1           1                     |             
      Duct, Hyperplasia                    |                      1        1                    1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  A  +  +|             
      Hyperplasia, Squamous                |                2                 2                    4        2         |             
      Inflammation                         |                                  3                    3                  |             
      Ulcer                                |                                  3                    4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|             
                                           | 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Inflammation                         |                               2  1                                      2|             
      Mineralization                       |                               2           3                              |             
      Ulcer                                |          2                                                     2        2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic                | 1  2  1  2  2  3  2  2  2  1  3  2  2  3  4  1  2  2  1  2  2  2     2  2|             
      Mineralization                       |                                           3                              |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Atrium, Thrombosis                   |          2                       2        2                 3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Degeneration, Fatty                  |             1  2  1  2  3     2                       3        1        1|             
      Focal Cellular Change                |                            2           3           1                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       3                    2        1                                    |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |    1        2           2  2  3        1        2     3        1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | I  M  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  A  +  +|             
      Hyperplasia                          |                      2        2           4                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +|             
      Pars Distalis, Hyperplasia           | 3                                   4                          2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      C-Cell, Hyperplasia                  |                2                    1  3                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +              +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | M  +  M  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  +|             
      Granuloma Sperm                      |                                                          4               |             
      Vacuolization Cytoplasmic            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                   3     2           3     2     2  2     2              2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |                               2                                          |             
      Inflammation, Suppurative            | 3                 4        2  2  3                 2     2     1        1|             
      Epithelium, Hyperplasia              |       1              4              1           1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|             
                                           | 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +                                                      |             
      Hemorrhage                           |                   3                                                      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3  3  3              3              3|             
      Interstitial Cell, Hyperplasia       | 1     1           1           1                    1  1  1              1|             
      Perivascular, Inflammation           |                                           2                             2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Myelofibrosis                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Mesenteric, Angiectasis              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  A  +  +|             
      Congestion                           |    3                                                                     |             
      Hyperplasia                          |                            2                                             |             
      Pigmentation, Hemosiderin            |                                                             4            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +|             
      Congestion                           |                                                             4            |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hyperplasia                          |                1           2           2        2  3     2              2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Fibrosis                             |                   2              2              2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  M  +  M  +  +  +  +  A  +  +  M  M  +  +  +  A  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  +  M  +  +  +  M  M  +  +  M  M  M  +  M  +  M  M  M  M|             
      Galactocele                          |                         2              1              2                  |             
      Hyperplasia                          |                1  1        2  1           1                 2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst Epithelial Inclusion            |    X                                                                     |             
      Inflammation, Suppurative            |                            3                                             |             
      Prepuce, Inflammation, Suppurative   | 2                                                                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                               2                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Fibrous Osteodystrophy               |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |                                                                3         |             
      Metaplasia, Osseous                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|             
                                           | 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
      Hemorrhage                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Suppurative            | 1              2     1                 1                 1  1  1         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |                                                             2            |             
      Inflammation, Chronic, Diffuse       |             3                                                            |             
      Inflammation, Chronic, Focal         |    1           2     2  1              1              3              1   |             
      Metaplasia, Osseous                  |                                        1                                 |             
      Mineralization                       |                               2           2                              |             
      Pigmentation, Hemosiderin            |                                  2  1                       1            |             
      Alveolar Epithelium, Hyperplasia     |                1                                      2              1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2              1        2  1                       1            |             
      Bronchiole, Epithelium, Hyperplasia  |                1                                                         |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Mononuclear Cell                |    2                                                                     |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                | 1  1                       1                             2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Foreign Body                         |                         1                          1                     |             
      Inflammation                         | 1           1  1  1     2  2  2  1  1  2     1  1  2     1     3        1|             
      Inflammation, Suppurative            | 1              1  1     1  1  2  1     1        1  2     1  2  3        1|             
      Thrombosis                           |                                  3                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                  1  1                                    |             
      Olfactory Epithelium, Degeneration   |                         1                          1        3            |             
      Olfactory Epithelium, Metaplasia     | 2                                      2           2                     |             
      Respiratory Epithelium, Hyperplasia  |                1        2  1  3  2  1              2           2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                               1                                1         |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                         1                                   3            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia              |    2                                                                     |             
      Epithelium, Metaplasia, Squamous     |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Inflammation,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|             
                             DAY ON TEST   | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|             
                                           | 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                           2           1                  |             
      Cornea, Inflammation, Suppurative    |                         1                 1                              |             
      Lens, Degeneration                   |          1                                2                       3      |             
      Retina, Atrophy                      |                                     2                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Cyst                                 |                            2                                             |             
      Mineralization                       |                               3           2                              |             
      Nephropathy                          | 1  2  1  1  3  4  2  3  3  3  4  3  3  2  4     3  2  4  3  3  2     3  4|             
      Renal Tubule, Hyperplasia            |                1                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Calculus Gross Observation           | X                 X                                                      |             
      Calculus Micro Observation Only      | X                 X                                                      |             
      Hemorrhage                           |                               3                                          |             
      Inflammation, Suppurative            | 1                             2                                          |             
      Mineralization                       |                               2                                          |             
      Transitional Epithelium, Hyperplasia | 2                 4           1                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5|            |
                             DAY ON TEST   | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7|            |
                                           | 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  M  +  M  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  M  +|  40        |
      Parasite Metazoan                    |                                  X                                       |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|  44        |
      Parasite Metazoan                    |          X           X                          X        X           X   |     10     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  M  A  +  M  +  +  +  +  A  +  +  +  A  +  +  +  M  +  +  +  A  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      4  2.0|
      Basophilic Focus                     |       1  1           2           1  1  2        2     1           2     1|     22  1.4|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  4.0|
      Degeneration, Cystic                 | 1                                                                        |      2  1.5|
      Degeneration, Fatty                  | 3                                         2                              |      6  2.8|
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |          X                                                        X      |      3     |
      Inflammation, Focal, Granulomatous   |       1  1              1           1           1                       1|     12  1.0|
      Necrosis                             |                2  4                       1  1                 1         |      8  1.8|
      Bile Duct, Hyperplasia               |    2     2     2     1     2  2  1  1  1  1  2  1  2     1  1  1  1     1|     32  1.4|
      Hepatocyte, Hyperplasia, Focal       |    2                                                                     |      1  2.0|
      Hepatocyte, Hyperplasia              | 1                                                                        |      4  2.0|
      Hepatocyte, Necrosis                 |                                                 1                        |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Inflammation, Chronic           |                                                                          |      2  2.5|
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acinus, Atrophy                      |    4           1     1        2  2     3  1                    1        1|     18  1.8|
      Acinus, Cytomegaly                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                              +                          +|   3        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                     1                                    |      4  1.0|
      Duct, Hyperplasia                    |          1           1        1     1           2  2  1  1               |     11  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5|            |
                             DAY ON TEST   | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7|            |
                                           | 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Squamous                | 3                       2                                                |      6  2.5|
      Inflammation                         | 3                       2                                                |      4  2.8|
      Ulcer                                | 4                       2                                                |      4  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectopic Tissue                       |                         X                                                |      1     |
      Inflammation                         |                         1                                                |      4  1.5|
      Mineralization                       |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                | 3  2  1  2     1  2  3  2  1  1  3  2  2     2  1  2  2  2  2  1  3  3  2|     47  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                      1   |      1  1.0|
      Atrium, Thrombosis                   |                                              2                           |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Degeneration, Fatty                  | 1  2  1        1     2  1  3                                2  1        1|     19  1.6|
      Focal Cellular Change                |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     |          1                             2                                 |      2  1.5|
      Hyperplasia                          |                                        2              2           2      |      6  2.0|
      Hypertrophy                          |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          | 2  2  1  2           3     2              1     3  4        3  2         |     20  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  M  +  +  +  M  M  I  +  M  +  +  +  +  +  +  +  +|  35        |
      Hyperplasia                          |                                                                   2      |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |                                  2        4  2        4                  |      7  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  45        |
      C-Cell, Hyperplasia                  | 2  2     2           2  3              2                          1     1|     11  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5|            |
                             DAY ON TEST   | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7|            |
                                           | 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +|  40        |
      Granuloma Sperm                      |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            | 2  2                                2           2     2  3        2      |      8  2.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|  45        |
      Cyst                                 |                         2                                                |      1  2.0|
      Inflammation, Suppurative            | 1  3  1        2              2        3        1  2  1                  |     17  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 2  3     2           2        1              2                 2     1  1|     18  2.0|
      Epithelium, Hyperplasia              |       2                             2                             1      |      7  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                        +                             +   |   3        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                        1                             2   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          3           2           3                                       |      8  2.9|
      Interstitial Cell, Hyperplasia       | 1                 1  1                          1        1               |     13  1.0|
      Perivascular, Inflammation           | 2                    3           1                                       |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Myelofibrosis                        |                3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mesenteric, Angiectasis              |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  44        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                                       1                  |      2  1.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  45        |
      Congestion                           |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |          2           2              2  2     2  2              2     2  2|     16  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             | 1                    2                                         1         |      6  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  M  M  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  M|  33        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  A  M  M  +  M  M  +  +  +  M  +  M  +  M  +  M  +  M  M  +  M|  23        |
      Galactocele                          |                      2        1                 1                    2   |      7  1.6|
      Hyperplasia                          | 2                                   2                 2     1            |     10  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5|            |
                             DAY ON TEST   | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7|            |
                                           | 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  I  M  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Prepuce, Inflammation, Suppurative   |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |    2                                                  2           2      |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrous Osteodystrophy               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |    1        1     1                    1              1     1  2  1      |     15  1.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |    1                                                                     |      2  1.5|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |    2                    1  2                       2        2  1         |     13  1.6|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      3  1.3|
      Alveolar Epithelium, Hyperplasia     |                         4                                      2         |      5  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                               1           1  1     2  1     1            |     11  1.3|
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |          1                          1           1     2                 1|      9  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Foreign Body                         |                                                          1               |      3  1.0|
      Inflammation                         | 1  1  1  1     1     2           1     2        2  2  1  2        1  1   |     30  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5|            |
                             DAY ON TEST   | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7|            |
                                           | 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |       1              1     1        1        3  2  1  1  1     1  1  1   |     26  1.3|
      Thrombosis                           |                2           2  2           2              1     1         |      7  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1                 1                 1        2     2              1  1   |      9  1.2|
      Olfactory Epithelium, Degeneration   |                                                 2                        |      4  1.8|
      Olfactory Epithelium, Metaplasia     |                                                 1                        |      4  1.8|
      Respiratory Epithelium, Hyperplasia  |                                        1  1     1        1               |     12  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  1.0|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation                         |                                  2                                       |      1  2.0|
      Inflammation, Suppurative            |                                                                2         |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
      Epithelium, Metaplasia, Squamous     |                                        1              1              1   |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      2  1.5|
      Cornea, Inflammation, Suppurative    |                                                                          |      2  1.0|
      Lens, Degeneration                   |             2                    1                                   1   |      6  1.7|
      Retina, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.5|
      Nephropathy                          | 4  2  3  3  1  2  1  3  3  3  3  2  2  3  2  1  3  2  3  2  3  2  3  2  2|     48  2.6|
      Renal Tubule, Hyperplasia            |                      2                                                   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Gross Observation           |                                                                          |      2     |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Hemorrhage                           |                               2                                          |      2  2.5|
      Inflammation, Suppurative            |                               2                                          |      3  1.7|
      Mineralization                       |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                      3                                                   |      5  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|             
                                           | 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  I  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | I  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |             2                          2                                 |             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1           2  2                                         1   |             
      Basophilic Focus                     |          1  2              X  1        1           1        1  1         |             
      Degeneration, Cystic                 |             1  2                 2  2                                    |             
      Degeneration, Fatty                  |    2                                                                     |             
      Eosinophilic Focus                   |                                     3                                    |             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hemorrhage                           |                      3                                                   |             
      Hepatodiaphragmatic Nodule           |             X                                                  X         |             
      Inflammation, Focal, Granulomatous   |             1     1        1  1     1  1           1        1            |             
      Leukocytosis                         |                                           2                              |             
      Necrosis                             |                      3     1        1     2  1  1                        |             
      Thrombosis                           |             2                                                            |             
      Bile Duct, Hyperplasia               |    1  2  1  2  3     2  1        2  2  1     1  2     1           2  2  1|             
      Hepatocyte, Hyperplasia, Focal       |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +              +                              |             
      Fat, Inflammation, Chronic           |                            3                                             |             
      Fat, Necrosis                        |                            3                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                2     1  1  1           2     1        1           2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                1                                   2        2            |             
      Duct, Hyperplasia                    |          1        1           1        1     1              2  1     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                   2        3                                             |             
      Inflammation                         |                   2        2                                      1      |             
      Ulcer                                |                   1                                               3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|             
                                           | 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ectopic Tissue                       |                                                       X                  |             
      Erosion                              |                                                                   3      |             
      Inflammation                         |    2                                2                                    |             
      Ulcer                                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2     1     1  2  2     2  2  1     1  1  1  2  2  3     1  3  2  2  1  2|             
      Atrium, Thrombosis                   |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1  1        2     1  1     2  2        1  2        2     2  1  2         |             
      Focal Cellular Change                |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3  1  3           3  1        4                          3  3  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                      1                                               2  1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  I  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                              1                           |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +  +  I  +  +  M  +  +  I  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                          3               |             
      Inflammation, Suppurative            |       1                 1  3           1           1  1  4  2  3        2|             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2     2  4  1  2     2     1                    1  1                  |             
      Epithelium, Hyperplasia              | 1                                                                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +                          +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|             
                                           | 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |             3                          1                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                4     4        1     2     4                    4         |             
      Interstitial Cell, Hyperplasia       |                   1  3     1                    1                    2   |             
      Perivascular, Inflammation           |                            1        2                          3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                  1                                2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |          2        3        2        3  2                    2  1         |             
      Inflammation, Granulomatous          |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis                             |                      2              1                             3      |             
      Hematopoietic Cell Proliferation     |                                           2                             2|             
      Necrosis                             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  M  +  +  M  +  +  M  +  M  M  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  +  +  +  M  +  +  M  M  +  M  +  M  M  +  M  M  +  M  M  M  +|             
      Galactocele                          |             1                       4                       1            |             
      Hyperplasia                          |    2           2  1        2                       2                    1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                            4                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            3           2                                 |             
      Hemorrhage                           |    1                             2           4                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|             
                                           | 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1        1           1                 2        1     2     4  1   |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   3      |             
      Hemorrhage                           |                      2  2                             3                  |             
      Infiltration Cellular, Mixed Cell    |                                           3                              |             
      Inflammation, Chronic, Focal         |    3     1  2        1  1     2                                1         |             
      Leukocytosis                         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    3  1                                            4                    1|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     1              2  3     1            |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                   1                 1                    1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             1                                         1                  |             
      Inflammation                         | 2     1  1  2     2     3  2  2     2  1  1        2  2     2  2        2|             
      Inflammation, Suppurative            | 1  1     1  2  1  1  1  1  1  1  1  2     2     1  1  1        2  4  1  1|             
      Thrombosis                           |                2                          3     1                        |             
      Mucosa, Cyst                         |                                                          2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    1                       2                                             |             
      Olfactory Epithelium, Metaplasia     |                   2                                                      |             
      Respiratory Epithelium, Hyperplasia  |             1           1  1     1  2        1  1     1        1         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    1                       1     2  2     1  1        2           1      |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |    1                                               1        1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             1                          2     1                 1         |             
      Epithelium, Hyperplasia              |                                        1                                 |             
      Epithelium, Metaplasia, Squamous     |                1        1     1                    1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +  +                                             |             
      Inflammation, Suppurative            |                         2  1                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|             
                                           | 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  3  2  2  3  2  3  2  2  3  3  2  2  3  2  2  2  3  2  2  3  3  3  2  2|             
      Renal Tubule, Hyperplasia            |                                     1                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2                                                            |             
      Transitional Epithelium, Hyperplasia |             2                                               2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3|            |
                                           | 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  A  +  +|  44        |
      Parasite Metazoan                    |    X                                      X                             X|      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |             2                                                            |      1  2.0|
      Parasite Metazoan                    |                            X           X                 X        X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  M  +  +  A  +  M  +  +  +  +  I  +  +  +|  42        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                2     2     2                       3        1            |      7  2.0|
      Parasite Metazoan                    |                                                 X                        |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |       2                                                        1        1|      7  1.4|
      Basophilic Focus                     |                1  1  1                    X     1     2        2  1  1  1|     18  1.2|
      Degeneration, Cystic                 |       2        2  1                                                      |      7  1.7|
      Degeneration, Fatty                  |                               2                          1               |      3  1.7|
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                         1        1           2     1                     |      5  1.4|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                  X                                       |      3     |
      Inflammation, Focal, Granulomatous   |                1  1              1  1        1  1  1     2     2  1  1   |     19  1.1|
      Leukocytosis                         |                                                                          |      1  2.0|
      Necrosis                             |       3  3                                                               |      8  1.9|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1  2  2     2  1  1  1              1     1     1  1  1  1  2        1  1|     32  1.4|
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   3        |
      Fat, Inflammation, Chronic           |       2                                                                  |      2  2.5|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |             1        3              1        2     2  1        1         |     15  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                         1                             2     1            |      6  1.5|
      Duct, Hyperplasia                    |    1                 1                       1     1  2  2  1           1|     16  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3|            |
                                           | 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |                               2                          1               |      4  2.0|
      Inflammation                         |                                                                          |      3  1.7|
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |                                                                          |      1     |
      Erosion                              |                                                                          |      1  3.0|
      Inflammation                         |    1  2                                                  2               |      5  1.8|
      Ulcer                                |                                           2                              |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  1  1  1     2  3  1  1  2  1  2  2  2  2  1  2  3  2  1  2  3  2  1  2|     44  1.7|
      Atrium, Thrombosis                   |                                                                   2      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |    1        1     1  1  1  1  2  1  1     2  1  2     2  1  2  1  1      |     30  1.4|
      Focal Cellular Change                |                               1     1                                    |      3  1.3|
      Hematopoietic Cell Proliferation     |                      1                 1  2                              |      3  1.3|
      Hyperplasia                          |                                                       3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |             1     2                             2        2           1  2|     15  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M  +  M  M  I  +  +  M  +  M  +  M  M  +  +  M  +  I  +  M  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                        X                                 |      1     |
      Pars Distalis, Hyperplasia           |             3  1  2     3        1     2                    3            |     10  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Hyperplasia                  |                2           3     2     1                                 |      5  1.8|
      Follicular Cell, Hyperplasia         |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  M  +  +  +  M  M  +  +  M  +  +  +  M  +  +  M  +  M  +  +  M  I|  36        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3|            |
                                           | 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
      Cyst                                 | X                                                                 X      |      2     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |          2     2                          1                          1  2|     15  1.8|
      Duct, Hyperplasia                    |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            | 1                 2  1  1  2        2  2  1  2        1  1  2     2  2   |     23  1.7|
      Epithelium, Hyperplasia              |                                                 1           1            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                          +               |   3        |
      Inflammation, Suppurative            |                                                          1               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       4                       4           2        2        3            |     11  3.1|
      Interstitial Cell, Hyperplasia       |                                     2                    2     2  2      |      9  1.8|
      Perivascular, Inflammation           |                                                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |       3                                                                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                              3                           |      1  3.0|
      Inflammation, Granulomatous          |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +|  43        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Hyperplasia                          |                   3     2  2  2              3     2              2  1  2|     16  2.1|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |                                                                         X|      1     |
      Fibrosis                             |       2                             1  3           1           2         |      8  1.9|
      Hematopoietic Cell Proliferation     |                         2                                                |      3  2.0|
      Necrosis                             |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M|  38        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  M  I  M  M  M  +  +  M  +  M  M  M  +  +  M  M  +  M  M  +  M|  20        |
      Galactocele                          |                                     2                                    |      4  2.0|
      Hyperplasia                          |       2                       2                                          |      8  1.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3|            |
                                           | 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |                                                 3  2                     |      2  2.5|
      Prepuce, Inflammation, Suppurative   |                         2                                                |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  2.5|
      Hemorrhage                           |    2        2                                2                    2      |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |    2  1                 1     1           1              1               |     14  1.4|
      Metaplasia, Squamous                 |                                     1                             1      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                          3        3      |      3  3.0|
      Hemorrhage                           |       1                                                              1   |      5  1.8|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |    3  2                 1                          1        1     1      |     13  1.5|
      Leukocytosis                         |          3                                      2                        |      2  2.5|
      Thrombosis                           |                                              2                           |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                  2                                       |      5  2.2|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                               1  1  1                                    |      7  1.4|
      Bronchiole, Inflammation, Suppurative|    1                                                                     |      1  1.0|
      Bronchiole, Epithelium, Hyperplasia  |    1                                                                     |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                         1                    1     1                 1   |      7  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      2  1.0|
      Inflammation                         |             2  1  2  2  1  1  1  2  2  2  1        1  3  2     2  2  2  2|     34  1.8|
      Inflammation, Suppurative            |                   1        1  1  1  1  1  1  1  1     2  1  1  1  1  2  1|     36  1.3|
      Thrombosis                           |                                                                          |      3  2.0|
      Mucosa, Cyst                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3|            |
                                           | 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    1 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   2                                               2     2|      5  1.8|
      Olfactory Epithelium, Metaplasia     |                                     1                                    |      2  1.5|
      Respiratory Epithelium, Hyperplasia  |          2                 1  1     1                 2     2        1  2|     17  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                           1                 1           1|     11  1.3|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                              2                           |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |    1                                                              1      |      6  1.2|
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
      Epithelium, Metaplasia, Squamous     | 1                                   1                                    |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy                          | 2  2  2     2  3  2  2  1  3  3  2  3  3  3  2  2  2  2  3  3  2  2  3  4|     49  2.4|
      Renal Tubule, Hyperplasia            |                                  2                                   1   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                               1                                          |      2  1.5|
      Transitional Epithelium, Hyperplasia |                               2                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|             
                                           | 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anus, Parasite Metazoan              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  +  +  +|             
      Parasite Metazoan                    |                X                 X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +|             
      Diverticulum                         |                                              3                           |             
      Inflammation                         |                                              2                           |             
      Parasite Metazoan                    |             X                                                     X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                    2        2        2                              |             
      Basophilic Focus                     |    2  2     2  2        2  1                 2              2  2  2      |             
      Degeneration, Cystic                 |                            1                          1     1     2      |             
      Degeneration, Fatty                  | 3                 1  1                                                   |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |                                        3                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Inflammation, Focal, Granulomatous   |       1  1                       1     1     1                    1  1   |             
      Leukocytosis                         |                                                                          |             
      Necrosis                             |                                                 2        1               |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    2  1  2     2        1  1  1     3  2  3  1  2     2        1        1|             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Hepatocyte, Necrosis                 |                                     1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Inflammation, Chronic           |                   3                                                      |             
      Fat, Necrosis                        |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             2                                                            |             
      Acinus, Atrophy                      |    3        3              2     1     2  2  2              2        1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1           1           2              1            |             
      Necrosis                             |                                                                      2   |             
      Duct, Hyperplasia                    |                      1  1        1        2  2  1     2     1           2|             
      Duct, Inflammation, Suppurative      |       1                                                                  |             
      Duct, Metaplasia, Squamous           |       1                                                                  |             
      Parotid Gland, Atrophy               |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|             
                                           | 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                      2     3                                             |             
      Inflammation                         |                      2     3                                             |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                            3                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                          2               |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                               3                    2                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                    4                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  2  1  2  3     2  2  3  3  2  2  2  3  2     3     2     3  2  2  2|             
      Mineralization                       |                               3                    3                     |             
      Atrium, Thrombosis                   |                               3                 3                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 4        2                                      2                       2|             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                         1                                                |             
      Hyperplasia                          |       2                                                                 2|             
      Inflammation, Chronic                |    3                                                                     |             
      Necrosis                             |    3                                                                     |             
      Pigmentation, Hemosiderin            |    3                                                                     |             
      Thrombosis                           |                               1                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       2           2              2  2                    2  3  2         |             
      Inflammation, Chronic                |    3                                                                     |             
      Necrosis                             |    3                                                                     |             
      Pigmentation, Hemosiderin            |    3                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
      Cytomegaly                           |                                                          1               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|             
                                           | 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                                                      4   |             
      Pars Distalis, Hyperplasia           |    3                             2                    3     2  3         |             
      Pars Intermedia, Degeneration, Cystic|                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2                                1     2                 2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | A  +  +  +  +  +  M  +  +  +  +  M  M  +  +  M  +  +  M  +  M  +  +  +  +|             
      Inflammation, Chronic                |                                                    4                     |             
      Mineralization                       |                                                    3                     |             
      Necrosis                             |                                                    4                     |             
      Vacuolization Cytoplasmic            |                      3        2        2                             2   |             
      Serosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |    1     2                    2  3  2  2  1     1  3  1                 2|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        1  2     2           2        2   |             
      Epithelium, Hyperplasia              |             4  3        1           1        3                          1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                  +                                       |             
      Inflammation, Suppurative            |                                  1                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3           3  3     4           4                 4              3  4   |             
      Mineralization                       |                                                    3                     |             
      Interstitial Cell, Hyperplasia       |          1        2                                3     1               |             
      Perivascular, Inflammation           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|             
                                           | 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                      2  1        2     2              2        2     2   |             
      Inflammation, Granulomatous          |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |    2                 1     3                    2                        |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Hemorrhage                           |                                                          4               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  +  +  +  M  M  +  +  M  M  +  M  M  +  M  +  +  +  +  M|             
      Galactocele                          |                      1                                      2        1   |             
      Hyperplasia                          |                2        2        1                                3      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               3                    4                     |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            |       1     1  1     1     1     2     2  1        2           1  1  2   |             
      Metaplasia, Squamous                 |          1                                   3                           |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 4           4                 3                                         3|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                   3                       2           2                  |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Inflammation, Chronic, Focal         |                   2              1                                       |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|             
                                           | 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukocytosis                         |                                                          X               |             
      Mineralization                       |                                                    1                     |             
      Pigmentation, Hemosiderin            |                               2                                          |             
      Alveolar Epithelium, Hyperplasia     |       2                                            1                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             1     2           2           1        2  3                  |             
      Alveolus, Inflammation, Suppurative  | 2                                                                        |             
      Artery, Intima, Inflammation, Chronic|                                                                          |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Bronchus, Inflammation, Suppurative  | 3                                                                    2   |             
      Bronchus, Epithelium, Hyperplasia    |                                                                          |             
      Bronchus, Epithelium, Metaplasia,    |                                                                          |             
           Squamous                        |                                                                          |             
      Peribronchiolar, Infiltration        |                                                                          |             
          Cellular, Mononuclear Cell       |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |             1  1        2              2                       1  2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                      1   |             
      Inflammation                         |    1  2  2        1        1  2  1  2  2  1  2  2  2  1  2  2  2  2  2  1|             
      Inflammation, Suppurative            | 4  1  1  2  1     1  1  1  1  3  1  1  1  1  1  1  2  1  1  1  1  2  1   |             
      Thrombosis                           |                                           2     3     2                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       1                 2  2        2  2           2     2     2         |             
      Olfactory Epithelium, Degeneration   |    1                          1  1                                       |             
      Olfactory Epithelium, Metaplasia     |                                  2                 2                     |             
      Respiratory Epithelium, Hyperplasia  | 2  1  1  1  1     1        1  3  1  2     1  2  2  3  2  2  2  2  1  1  1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2        2        1                 2     1  1  1  1  3  1  1           2|             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                        2        2  2     1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                                                                1         |             
      Mineralization                       |                                                    2                     |             
      Epithelium, Metaplasia, Squamous     |    1           1                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Synechia                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|             
                                           | 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    2 MG/M3                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cornea, Hyperplasia                  |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                    2                     |             
      Cornea, Mineralization               |    1                                               1                     |             
      Lens, Degeneration                   | 2           2                                                  1         |             
      Lens, Mineralization                 |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
      Sclera, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hydronephrosis                       |                                                    3                     |             
      Nephropathy                          | 3  3  3  3  3  3  1  3  3  4  4  4  3  2  2  3  3  4  2     3  3  4  3  3|             
      Pelvis, Inflammation, Suppurative    |                                                    2                     |             
      Renal Tubule, Hyperplasia            |                                                                   2      |             
      Renal Tubule, Inflammation,          |                                                                          |             
          Suppurative                      | 1                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3|            |
                                           | 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Anus, Parasite Metazoan              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  M  +  +  +  M  +  +  M  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +|  39        |
      Parasite Metazoan                    |                                                    X                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Diverticulum                         |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                            X                       X                     |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          2                                                               |      5  2.0|
      Basophilic Focus                     |    1     2  1  1        2     1        1        1  1  1           1      |     21  1.5|
      Degeneration, Cystic                 |          2           1                 3           1                     |      8  1.5|
      Degeneration, Fatty                  |                                     1        3  2           2  3         |      8  2.0|
      Degeneration                         |                                                                      4   |      1  4.0|
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |             2                       1                 2                  |      3  1.7|
      Hepatodiaphragmatic Nodule           |          X     X                       X                                 |      4     |
      Inflammation, Focal, Granulomatous   | 1  1           1  1           1           1  1  1     1                  |     16  1.0|
      Leukocytosis                         |                                           X                              |      1     |
      Necrosis                             |                                           1           1                 2|      5  1.4|
      Thrombosis                           |                                                                         2|      1  2.0|
      Bile Duct, Hyperplasia               | 1        1  1  2     1                 1        1     1  2  3  3  2  3  2|     29  1.7|
      Hepatocyte, Hyperplasia              |                                        2                                 |      1  2.0|
      Hepatocyte, Necrosis                 |                                                 1                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +           +                                                |   3        |
      Fat, Inflammation, Chronic           |             4           3                                                |      3  3.3|
      Fat, Necrosis                        |             4                                                            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                1                             1                           |      3  1.3|
      Acinus, Atrophy                      |          3  2  1  1  2  2     4     1  1  1     1     2     2  1  3  1   |     25  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Inflammation                         |    1                                                                 1   |      6  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3|            |
                                           | 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |    1                                1     1                          1   |     13  1.3|
      Duct, Inflammation, Suppurative      |                                                                          |      1  1.0|
      Duct, Metaplasia, Squamous           |                                                                          |      1  1.0|
      Parotid Gland, Atrophy               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Squamous                |                                     3     4  3  1              4         |      7  2.9|
      Inflammation                         |                                     3     3     1              4         |      6  2.7|
      Mineralization                       |                      2                                                   |      1  2.0|
      Ulcer                                |                                           1                    4         |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation                         |                                                             2            |      1  2.0|
      Mineralization                       |                      4                                                   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                        +                                 |   1        |
      Inflammation, Chronic                |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                 +  +                                                |   4        |
      Inflammation                         |    3                    2                                                |      2  2.5|
      Mineralization                       |                      3                                                   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1  2     2  2  2  1  4  2  2  2  1  4  2  1     2  2  1  1     1  2      |     41  2.0|
      Mineralization                       |                      3                                                   |      3  3.0|
      Atrium, Thrombosis                   |             2                                                  3         |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |    1     2  2  2     1  2              1  3     2     2  2  1  2  1      |     18  1.9|
      Focal Cellular Change                |             1                 2                       1                  |      3  1.3|
      Hematopoietic Cell Proliferation     |             1                                                     2      |      3  1.3|
      Hyperplasia                          |                               2                                          |      3  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3|            |
                                           | 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |             1                                                            |      1  1.0|
      Hyperplasia                          |    2     2                    2        3  2        2  2                  |     14  2.1|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cytomegaly                           |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  44        |
      Hyperplasia                          |                      4                    2                              |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                        3                                 |      1  3.0|
      Pars Distalis, Cyst                  |       2                                                                  |      1  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                                   2      |      6  2.5|
      Pars Intermedia, Degeneration, Cystic|       2                                                                  |      1  2.0|
      Pars Intermedia, Hyperplasia         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |          2  4  2              2                             1     1      |     10  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  M  +  +  +  +  +  +  +  +  +  M  I  +  +  +  +  +  +  +  M  +  +  +|  39        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  2.3|
      Serosa, Hyperplasia                  |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    3                     |      1  3.0|
      Inflammation, Suppurative            |    1     4  3  1        2     3     2  2                 2     2  1     1|     23  1.9|
      Duct, Ectasia                        |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |             2           2  2  2     1  2  1              2        1  2   |     15  1.7|
      Epithelium, Hyperplasia              |                      1                                1              1   |      9  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                  +                                       |   2        |
      Inflammation, Suppurative            |                                  1                                       |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3|            |
                                           | 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          3        1  4                       1  1           4            |     14  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |       1        1  1     1        1  1     1              1               |     12  1.3|
      Perivascular, Inflammation           |                                           2                              |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                         3                                                |      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |          3                                                        3      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|  45        |
      Angiectasis                          |                                                       2                  |      1  2.0|
      Hyperplasia                          |       2  2  2        2     2                    2  2  3                  |     15  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Developmental Malformation           |          X                                                               |      1     |
      Fibrosis                             |                      2                    3        3              2      |      8  2.3|
      Hematopoietic Cell Proliferation     |             3                       2                                    |      3  2.3|
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M  M  I  +  I  M  +  +  +  +  +  M  M  M  +  I  M  +  M  +  M|  23        |
      Galactocele                          |                      1           1  1     2           2        2     1   |     10  1.4|
      Hyperplasia                          |    1  2                       2        2                                 |      8  1.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |             4                                                            |      1  4.0|
      Subcutaneous Tissue, Necrosis        |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                      3                                                   |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3|            |
                                           | 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Hyperostosis                         |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                           4                          3   |      2  3.5|
      Thrombosis                           |                                           4                              |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    1     1  2  1              1        1                 1     1        2|     21  1.3|
      Metaplasia, Squamous                 |                               1                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      4  3.5|
      Foreign Body                         |       1                                                                  |      1  1.0|
      Hemorrhage                           |          2           1  2                                   1            |      7  1.9|
      Infiltration Cellular, Mixed Cell    |             2                                                            |      1  2.0|
      Inflammation, Chronic, Diffuse       |                      3                                                   |      1  3.0|
      Inflammation, Chronic, Focal         |                         2              2                 2               |      5  1.8|
      Inflammation, Focal, Granulomatous   |       3  4                                                               |      2  3.5|
      Leukocytosis                         | 2                                                                        |      2  2.0|
      Mineralization                       |                      4                                                   |      2  2.5|
      Pigmentation, Hemosiderin            |          3                                                               |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |       1  3     3                       2                                 |      6  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      3                                   2               |      8  2.0|
      Alveolus, Inflammation, Suppurative  |                                                                          |      1  2.0|
      Artery, Intima, Inflammation, Chronic|                                                                2         |      1  2.0|
      Bronchiole, Inflammation, Suppurative|       2                                                                  |      1  2.0|
      Bronchiole, Epithelium, Hyperplasia  |       2                                1                                 |      2  1.5|
      Bronchus, Inflammation, Suppurative  |                                                                          |      2  2.5|
      Bronchus, Epithelium, Hyperplasia    |                                        2                                 |      1  2.0|
      Bronchus, Epithelium, Metaplasia,    |                                                                          |            |
           Squamous                        |                                        1                                 |      1  1.0|
      Peribronchiolar, Infiltration        |                                                                          |            |
          Cellular, Mononuclear Cell       |                         2                                                |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |    1           1  2     2     1        2              1                  |     13  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3|            |
                                           | 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Foreign Body                         |       1              1                                                   |      3  1.0|
      Inflammation                         | 1  1  3  2  1  1  1  3  2  2  2  2  3  2  2     1  3  3  2  2  2  2  2  2|     44  1.8|
      Inflammation, Suppurative            |    1  3  1  1  1     2  1  1  2  1  2  1  1  1  1  1  2  1  2  1  1  1  2|     46  1.3|
      Thrombosis                           |                                                                2        3|      5  2.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                      2                    2  1        2  1           2   |     14  1.8|
      Olfactory Epithelium, Degeneration   |                                                 1     2              1   |      6  1.2|
      Olfactory Epithelium, Metaplasia     | 1     2           1                          1                       1   |      7  1.4|
      Respiratory Epithelium, Hyperplasia  | 1  2  3  1  2  1  1  3     2  1     2  1  3  1  1  2  2  1  2  2  1  1  2|     44  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |       2     1     1  2     2              3  1  2  2  3  2  2  2  2     3|     27  1.8|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                           2                 2            |      6  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                         2                                                |      1  2.0|
      Inflammation, Suppurative            |                      2                                            1  1  1|      5  1.2|
      Mineralization                       |                      2                                                   |      2  2.0|
      Epithelium, Metaplasia, Squamous     |                      1        1                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Synechia                             |                                                       2                  |      1  2.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                      2                                                   |      2  2.0|
      Cornea, Hyperplasia                  |                      2                                                   |      1  2.0|
      Cornea, Inflammation, Suppurative    |                1     2                                                   |      3  1.7|
      Cornea, Mineralization               |                      1                                                   |      3  1.0|
      Lens, Degeneration                   | 3        4                                         2  3                  |      7  2.4|
      Lens, Mineralization                 |          2                                            2                  |      2  2.0|
      Retina, Atrophy                      |          4                                            4                  |      2  4.0|
      Sclera, Inflammation                 |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Nephropathy                          | 1  3     2  3  3  2  4  3  1  3  3  2  4  4  1  3  3  3  2  2  2  1  1  2|     48  2.7|
      Pelvis, Inflammation, Suppurative    | 2                                                                        |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05097-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      ALPHA-CHLOROACETOPHENONE                                 Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 09:03:48  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3|            |
                                           | 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    2 MG/M3                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|
      Renal Tubule, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
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