TDMS Study 05097-01 Pathology Tables
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
Facility: Battelle Northwest
Chemical CAS #: 532-27-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|
DAY ON TEST | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|
| 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + M + + + + + + + +|
Anus, Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + M + + + + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M M + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + M + + M + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + M + + + + + + I A|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Basophilic Focus | 1 1 1 1 2 2 1 2 3 2 3 2 1 1 1 1 1|
Clear Cell Focus | |
Degeneration, Fatty | 1 2 2 |
Hematopoietic Cell Proliferation | 2 1 1 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Focal, Granulomatous | 2 1 1 1 2 2 2 1 2 1 1 1 1 1|
Leukocytosis | 2 |
Necrosis | 2 1 1 1 2 2 |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 |
Hepatocyte, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | |
Inflammation, Granulomatous, | |
Multifocal, Suppurative | 3 |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation | 1 |
Acinus, Atrophy | 3 2 1 2 2 |
Acinus, Cytomegaly | 1 1 |
__________________________________________________________________________|
Pharynx | |
Palate, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + A + + + + + + + +|
Duct, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + I + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|
DAY ON TEST | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|
| 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Chronic | 2 1 2 1 2 2 2 3 1 2 2 2 2 1 1 1 2 1 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Degeneration, Fatty | 2 1 2 1 3 2 1 2 2 3 |
Focal Cellular Change | 2 2 1 |
Hematopoietic Cell Proliferation | 1 1 2 2 |
Hyperplasia | 2 1 2 4 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 1 3 2 2 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + M + + + M M + M M M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Degeneration, Cystic | 3 |
Pars Distalis, Hyperplasia | 1 1 2 3 2 2 |
Pars Distalis, Infiltration Cellular,| |
Mixed Cell | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + M + + + + A|
Cyst | X |
C-Cell, Hyperplasia | 2 3 2 2 4 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + A + + M + + + M +|
Cyst | X X |
Hyperplasia | 2 |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|
DAY ON TEST | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|
| 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Hyperplasia | 4 |
Duct, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | 3 3 3 3 3 3 |
Cyst | X X X X |
Interstitium, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Suppurative | |
Endometrium, Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +|
Depletion Cellular | |
Myelofibrosis | 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + A + + + + + + + +|
Axillary, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + I + + A + + + + + + M +|
Hyperplasia | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + A + + + + + + + M|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 2 2 4 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 2 1 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + M + + + + A M + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Galactocele | 1 2 1 2 1 |
Hyperplasia | 2 1 1 |
Inflammation, Chronic | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + A + + + + + + + +|
Acanthosis | 2 |
Inflammation, Suppurative | 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + A + + + + + + + +|
Fracture | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|
DAY ON TEST | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|
| 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Inflammation, Chronic, Suppurative | 3 |
Osteopetrosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hemorrhage | 3 |
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + M + + + + + + + + + + + + + A + + + + + + + +|
Inflammation | 2 |
Inflammation, Suppurative | 1 2 1 1 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +|
Congestion | 4|
Hemorrhage | 2 2 1 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic, Focal | 1 2 2 |
Pigmentation, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 3 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + A|
Foreign Body | 1 1 |
Inflammation | 1 1 2 1 1 2 2 2 1 2 1 2 1 1 1 1 2 |
Inflammation, Suppurative | 1 2 1 1 1 1 1 1 1 1 4 1 1 1 |
Thrombosis | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 |
Olfactory Epithelium, Degeneration | 1 1 |
Olfactory Epithelium, Metaplasia | 1 2 1 2 |
Respiratory Epithelium, Hyperplasia | 2 1 1 1 1 1 1 1 3 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + A|
Inflammation | 2 1 |
Inflammation, Suppurative | 1 1 |
Epithelium, Hyperplasia | 2 2 |
Epithelium, Metaplasia, Squamous | 1 3 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 6| 0| 6| 7| 6| 5| 5|
DAY ON TEST | 5| 3| 5| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 0| 3| 3| 7| 0| 0| 4| 0| 3| 5| 3| 8|
| 9| 7| 8| 5| 1| 5| 5| 5| 5| 5| 5| 7| 5| 0| 5| 1| 7| 0| 2| 8| 9| 5| 4| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + M + + + + + + + +|
Synechia | |
Cornea, Inflammation, Suppurative | |
Lens, Degeneration | 1 |
Lens, Mineralization | |
Retina, Atrophy | 1 1 1 |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Inflammation | 2 |
Inflammation, Suppurative | 1 1 |
Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Lacrimal Gland | + + + |
Acinus, Atrophy | 2 1 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | 1 |
Nephropathy | 1 3 1 3 1 1 3 1 2 2 2 1 1 1 3 2 2 1 3 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7| |
| 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Anus, Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + I M + + + + + + + + + + + + +| 44 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Lymphoid | 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | 2 1 1 2 1 2 1 2 1 1 1 2 1 1 | 31 1.5|
Clear Cell Focus | 1 | 1 1.0|
Degeneration, Fatty | 2 1 2 4 2 3 3 1 3 3| 13 2.2|
Hematopoietic Cell Proliferation | 1 1 | 7 1.1|
Hemorrhage | 4 | 1 4.0|
Hepatodiaphragmatic Nodule | X X | 5 |
Inflammation, Focal, Granulomatous | 2 2 1 2 2 2 1 1 2 1 2 2 | 26 1.5|
Leukocytosis | | 1 2.0|
Necrosis | 3 | 7 1.7|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 2 1 1 1| 17 1.4|
Hepatocyte, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Granulomatous, | | |
Multifocal, Suppurative | | 1 3.0|
Fat, Inflammation, Chronic | 3 | 2 3.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 1 | 4 1.0|
Acinus, Atrophy | 1 1 1 2 1 3 3 1 1 1 | 15 1.7|
Acinus, Cytomegaly | | 2 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7| |
| 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Hyperplasia | 1 2 1 1 1 1 1 1 1 2| 14 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Hyperplasia, Squamous | 3 4 | 2 3.5|
Inflammation | 2 | 1 2.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 3 1 1 2 1 1 2 2 1 2 1 3 2 1 1 1 1 2| 38 1.6|
Atrium, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2 1 1 2 1 2 2 1 2 2 1 2 | 22 1.7|
Focal Cellular Change | 2 2 1 1 2| 8 1.6|
Hematopoietic Cell Proliferation | 1 | 5 1.4|
Hyperplasia | 2 2 2 2 2 | 10 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 3 1 2 2 3 | 15 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + M M + + + M + + + M + + M + M M +| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Degeneration, Cystic | 3 3 | 3 3.0|
Pars Distalis, Hyperplasia | 2 2 3 1 4 2 3 | 13 2.2|
Pars Distalis, Infiltration Cellular,| | |
Mixed Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | | 1 |
C-Cell, Hyperplasia | 3 1 1 2 2 1 3 1 2 2 3 2 2 3 | 24 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7| |
| 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Cyst | | 2 |
Hyperplasia | 3 | 2 2.5|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | 2 2 4 2 2 | 6 2.2|
Duct, Hyperplasia | 3 | 2 3.5|
Duct, Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 | 8 3.0|
Cyst | X X | 6 |
Interstitium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 | 1 3.0|
Endometrium, Cyst, Multiple | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Cellular | 2 | 1 2.0|
Myelofibrosis | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Axillary, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + I + + M + + + + + + + +| 44 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2| 15 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 1 | 2 1.0|
Hematopoietic Cell Proliferation | 2 | 5 2.0|
__________________________________________________________________________|____________|
Thymus | M + + M + M + + + + + + + + + + + M + + + M M M +| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7| |
| 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | 1 2 2 1 1 | 10 1.4|
Hyperplasia | 1 2 1| 6 1.3|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fracture | X | 1 |
Inflammation, Chronic, Suppurative | | 1 3.0|
Osteopetrosis | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | 2 | 2 2.0|
Inflammation, Suppurative | 1 2 1 1 1 1 2 1 1 1 1 1 1| 18 1.2|
Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 4.0|
Hemorrhage | 1 | 4 1.5|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 | 5 1.4|
Pigmentation, Hemosiderin | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 1 1 1 1 | 11 1.4|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 1 1 1 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 6| 6| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 7| 7| 7| 3| 3| 9| 5| 3| 3| 0| 7| 3| 3| 3| 7| 3| 9| 3| 3| 8| 3| 7| |
| 5| 5| 1| 7| 7| 0| 5| 5| 7| 9| 5| 5| 2| 9| 5| 5| 5| 3| 3| 4| 5| 5| 7| 5| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation | 1 2 1 2 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 1 2 3| 41 1.4|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3| 29 1.2|
Thrombosis | 2 1 2 2| 7 1.9|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 2 2 1 | 7 1.7|
Olfactory Epithelium, Degeneration | | 2 1.0|
Olfactory Epithelium, Metaplasia | | 4 1.5|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1| 20 1.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2 1 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation | | 2 1.5|
Inflammation, Suppurative | 1 | 3 1.0|
Epithelium, Hyperplasia | | 2 2.0|
Epithelium, Metaplasia, Squamous | | 3 1.7|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Synechia | 3 | 1 3.0|
Cornea, Inflammation, Suppurative | 1 | 1 1.0|
Lens, Degeneration | 3 1 | 3 1.7|
Lens, Mineralization | 3 | 1 3.0|
Retina, Atrophy | 1 4 1 | 6 1.5|
__________________________________________________________________________|____________|
Harderian Gland | | 5 |
Inflammation | | 1 2.0|
Inflammation, Suppurative | | 2 1.0|
Metaplasia, Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 3 |
Acinus, Atrophy | | 3 1.7|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | | 1 1.0|
Nephropathy | 2 2 2 2 2 3 2 3 2 3 2 2 2 4 2 2 3 1 2 1 2 3 2 3 2| 48 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|
| 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + I + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + A + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A M + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + A + M + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + A + + + + |
Hyperplasia, Lymphoid | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 3 1 |
Basophilic Focus | X 1 2 1 1 1 1 2 1 1 1 |
Degeneration, Fatty | 2 1 2 2 1 3 |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Focal, Granulomatous | 2 2 3 1 2 1 1 1 1 2 1 2 |
Necrosis | 1 |
Bile Duct, Hyperplasia | 1 2 2 |
Hepatocyte, Hyperplasia, Focal | 3 |
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Acinus, Atrophy | 1 2 1 |
Acinus, Cytomegaly | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + |
Inflammation, Suppurative | 1 |
Duct, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | I + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 2 |
Inflammation | 2 1 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|
| 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 2 1 2 1 1 2 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 2 1 1 1 2 1 1 2 1 2 1 2 2|
Degeneration | 2 |
Focal Cellular Change | 1 1 |
Hematopoietic Cell Proliferation | 1 1 1 |
Hyperplasia | |
Hypertrophy | |
Necrosis | 1 |
Bilateral, Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M |
__________________________________________________________________________|
Parathyroid Gland | + I + M M M + + M + + + + + M |
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 3 3 3 |
Pars Distalis, Mineralization | |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + I + + + + + + M + + |
Hyperplasia | 2 |
Inflammation, Suppurative | 2 1 2 1 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Atrophy | 2 2 |
Cyst | 1 3 1 X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + |
Dilatation | 2 |
Prolapse | X |
Endometrium, Cyst, Multiple | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|
| 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hypertrophy | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + |
Pancreatic, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M + + + M + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Inflammation, Focal, Granulomatous | |
__________________________________________________________________________|
Thymus | + M M + + + + + M + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 1 1 1|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + |
Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Necrosis | |
Subcutaneous Tissue, Thrombosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | |
Osteopetrosis | 2 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Hemorrhage | 1 1 |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + I + + + + |
Hyperplasia | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|
| 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 2 1 1 1 |
Inflammation, Chronic, Focal | 1 1 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 3 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Mediastinum, Inflammation, | |
Granulomatous | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation | 1 2 2 1 2 3 1 1 3 2 2 2 2 1 1 1 3 2 1 1|
Inflammation, Suppurative | 1 1 2 1 1 1 1 1 1 |
Thrombosis | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 2 1 2 1 |
Olfactory Epithelium, Metaplasia | 2 1 |
Respiratory Epithelium, Hyperplasia | 2 1 2 2 1 1 2 1 1 1 1 1 2 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 3 |
Respiratory Epithelium, Ulcer | |
Vomeronasal Organ, Inflammation | 1 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + I + + + + |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 1 |
Epithelium, Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Synechia | |
Lens, Degeneration | |
Lens, Mineralization | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Lacrimal Gland | + +|
Acinus, Atrophy | 2 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 6| 3| 3| 1| 3| 3| 3| 1| 3| 3| 0| 5| 3| 0| 3| 7| 3| 8| 4| 3| 3| 3| 1| 8| 3|
| 0| 1| 8| 3| 7| 1| 7| 6| 7| 7| 7| 3| 7| 0| 7| 1| 7| 7| 0| 7| 7| 7| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 2 2 2 2 2 2 2 2 3 2 1 2 2 4 2 2 |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3| |
| 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + +| 28 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + +| 28 |
Parasite Metazoan | X X| 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + M + + +| 27 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + +| 41 |
Angiectasis | 1 | 4 1.5|
Basophilic Focus | 2 2 1 1 1 1 2 2 1 1 2 1 1 1| 25 1.3|
Degeneration, Fatty | 2 1 1 3 3 2 2 | 13 1.9|
Eosinophilic Focus | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hepatodiaphragmatic Nodule | X X X | 6 |
Inflammation, Focal, Granulomatous | 2 1 1 2 1 1 1 1 1 1 1 1 1| 25 1.4|
Necrosis | 1 | 2 1.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 | 8 1.4|
Hepatocyte, Hyperplasia, Focal | 3 | 2 3.0|
Hepatocyte, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + +| 30 |
Acinus, Atrophy | 2 1 2 | 6 1.5|
Acinus, Cytomegaly | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + +| 29 |
Inflammation, Suppurative | | 1 1.0|
Duct, Hyperplasia | 1 1 1 2| 8 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 3 2 2 3| 6 2.5|
Inflammation | 3 2 2 1 2| 7 1.9|
Ulcer | 3 1 2| 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3| |
| 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + +| 30 |
Inflammation, Chronic | 2 1 1 1 1 2 2 2 | 16 1.6|
Atrium, Thrombosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 2 1 3 2 1 2 1 2 1 2 1 1 2 | 29 1.5|
Degeneration | 3 | 2 2.5|
Focal Cellular Change | 1 1 2 | 5 1.2|
Hematopoietic Cell Proliferation | 1 2 1 1 | 7 1.1|
Hyperplasia | 2 2 | 2 2.0|
Hypertrophy | 3 | 1 3.0|
Necrosis | | 1 1.0|
Bilateral, Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 3 1 2 1| 10 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M| 22 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 4 3 | 5 3.2|
Pars Distalis, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + +| 30 |
C-Cell, Hyperplasia | 2 1 1 2 1 1 1 1 1| 14 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3| |
| 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 1 | 3 1.7|
Inflammation, Suppurative | 2 3 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + +| 31 |
Atrophy | 2 | 3 2.0|
Cyst | | 4 1.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + +| 33 |
Dilatation | | 1 2.0|
Prolapse | | 1 |
Endometrium, Cyst, Multiple | 1 | 1 1.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Hypertrophy | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + +| 31 |
Pancreatic, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + + + M + + + +| 26 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +| 30 |
Hyperplasia | 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 35 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + I + + + + M +| 24 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 2 1 1 | 8 1.1|
Hyperplasia | 2 2 1 3 3 1 | 9 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + +| 27 |
Inflammation, Suppurative | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 | 1 4.0|
Subcutaneous Tissue, Necrosis | 4 | 1 4.0|
Subcutaneous Tissue, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3| |
| 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + +| 30 |
Fibrous Osteodystrophy | 2| 1 2.0|
Osteopetrosis | 1 | 4 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + +| 30 |
Hemorrhage | | 2 1.0|
Hydrocephalus | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + I + + +| 27 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + +| 40 |
Hemorrhage | 1 1 1 | 7 1.1|
Inflammation, Chronic, Focal | 2 1 1 1 1 1 | 9 1.1|
Thrombosis | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 3 1 2 | 6 1.5|
Mediastinum, Inflammation, | | |
Granulomatous | 3 | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 2 1 | 10 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 1.0|
Inflammation | 3 1 1 1 1 2 2 2 2 2 1 1 2 2 1 1 1 3 1 1 2| 41 1.6|
Inflammation, Suppurative | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 | 27 1.1|
Thrombosis | 1 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 2 1 | 11 1.5|
Olfactory Epithelium, Metaplasia | 1 | 3 1.3|
Respiratory Epithelium, Hyperplasia | 3 1 2 2 1 1 3 1 2 1 1 1 1 1 3 1 | 31 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 2 1 | 7 1.6|
Respiratory Epithelium, Ulcer | 3 | 1 3.0|
Vomeronasal Organ, Inflammation | | 2 1.0|
Vomeronasal Organ, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7| 6| 6| 7| |
DAY ON TEST | 7| 5| 3| 9| 6| 5| 3| 3| 8| 0| 3| 3| 2| 4| 0| 3| 3| 3| 3| 4| 1| 3| 1| 7| 3| |
| 9| 8| 7| 4| 6| 8| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 9| 7| 6| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + +| 29 |
Inflammation, Suppurative | 1 1| 2 1.0|
Epithelium, Hyperplasia | | 1 1.0|
Epithelium, Metaplasia, Squamous | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Synechia | 4 | 1 4.0|
Lens, Degeneration | 3 | 1 3.0|
Lens, Mineralization | 2 | 1 2.0|
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Inflammation, Suppurative | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 3 |
Acinus, Atrophy | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + +| 37 |
Cyst | 2 | 1 2.0|
Nephropathy | 2 3 2 2 2 2 1 2 2 3 2 2 2 2 1 2 3 2 1 4| 37 2.1|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|
| 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + M I + + + + A M + + + + + + A + + M + + + + M +|
Inflammation | 3 |
Parasite Metazoan | X X X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + M|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + A M + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + A + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 2 1 1 1 1 2 1 1 1 1 1 2 1 3 1 2|
Degeneration, Fatty | 3 2 1 2 1 |
Hematopoietic Cell Proliferation | 2 2 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 1 3 2 1 1 2 1 1 2 1 2 1 3|
Leukocytosis | 2 2 2 |
Necrosis | 1 1 1|
Pigmentation, Hemosiderin | |
Bile Duct, Hyperplasia | 1 1 1 1 1 2|
Hepatocyte, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic | 1 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + I + + + + + + + +|
Inflammation | 1 |
Acinus, Atrophy | 3 1 1 2 2 2|
Acinus, Cytomegaly | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1|
Duct, Hyperplasia | 1 1 2 1 2 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 2 2 3 2 |
Inflammation | 1 3 2 2 1 4 |
Ulcer | 1 2 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|
| 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | 2 1 |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 3 2 1 2 1 1 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Degeneration, Fatty | 1 2 1 2 2 2 3 1 2 2 2 1|
Degeneration | 3 |
Focal Cellular Change | 1 3 |
Hematopoietic Cell Proliferation | 1 2 2 1 1 1 |
Hyperplasia | 3 2 1 2 2 2|
Hypertrophy | |
Inflammation, Chronic | |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 2 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + M + M + + + + + + M + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Degeneration, Cystic | 2 |
Pars Distalis, Hyperplasia | 2 2 2|
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + A + A + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 4 2 3 4 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + M M M + + + + + M + + + + M + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|
| 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 |
Cyst | X |
Infiltration Cellular, Mixed Cell | |
__________________________________________________________________________|
Oviduct | |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Cyst | X |
Endometrium, Inflammation, | |
Suppurative | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Inflammation, | |
Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | I + + + + + M + + + + M + + + + + + + M + M + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + I + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 2 2 2 3 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1|
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Focal, Granulomatous | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
Hyperplasia | 1 2 2 1 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|
| 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Suppurative | 1 1 1 1 2 2 1 1 2 1 2 1 1|
Metaplasia, Squamous | 2 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Chronic, Focal | 2 1 |
Metaplasia, Squamous | 1 |
Pigmentation, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 2 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
Bronchus, Mineralization | 2 |
Bronchus, Epithelium, Hyperplasia | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 2 2 1 1 2 |
Pleura, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation | 2 2 2 2 2 2 1 1 2 2 2 2 1 1 2 3 2 2 2 2|
Inflammation, Suppurative | 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | 1 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 2 |
Olfactory Epithelium, Degeneration | 1 |
Olfactory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Hyperplasia | 2 2 3 2 2 3 1 1 2 1 2 2 1 2 3 2 2 2 1 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 1 1 2 2 1 2 1 4 2 1 1 2 2|
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 6| 7| 4| 5| 6| 7| 7| 6| 7| 6| 5| 7| 5| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 0| 8| 0| 7| 2| 1| 3| 3| 8| 3| 8| 1| 3| 1| 3| 1| 3| 3| 9| 3|
| 6| 8| 6| 6| 0| 0| 6| 5| 7| 3| 0| 6| 6| 2| 6| 2| 4| 1| 2| 6| 2| 6| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Epithelium, Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + A + + + + + + + + + + + + + + + + +|
Synechia | 3 |
Lens, Degeneration | 1 4 2 |
Lens, Mineralization | 2 |
Retina, Atrophy | 1 4 1 1 1|
__________________________________________________________________________|
Harderian Gland | + + + + +|
Inflammation, Suppurative | 1 1 1 1 |
Metaplasia, Squamous | 1 1|
__________________________________________________________________________|
Lacrimal Gland | + |
Acinus, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy | 2 2 2 4 3 2 2 1 2 3 2 3 1 2 1 2 1 3 3 1 2 3 1 2|
Papilla, Necrosis | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| |
DAY ON TEST | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3| |
| 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + + + + + + M + M + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + + + + + + M + + + + + + + + + + + + + +| 41 |
Inflammation | | 1 3.0|
Parasite Metazoan | X | 4 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M A + + + + + + + I M + + + + + M + + + + + + +| 43 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + I + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + M + + + + + + +| 45 |
Hyperplasia, Lymphoid | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 1 | 3 1.7|
Basophilic Focus | 1 2 2 1 2 1 1 1 1 2 1 1 2 1 1| 33 1.3|
Degeneration, Fatty | 1 3 1 2 1 | 10 1.7|
Hematopoietic Cell Proliferation | 2 1 | 5 1.6|
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation, Focal, Granulomatous | 2 1 2 1 2 2 1 2 2 1 2 2 2| 26 1.7|
Leukocytosis | | 3 2.0|
Necrosis | 1 1 2 1 | 7 1.1|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 2 1 1 2 1 1| 13 1.2|
Hepatocyte, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Inflammation, Chronic | | 1 1.0|
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation | 2 | 2 1.5|
Acinus, Atrophy | 1 2 2 1 1 1 2 2 | 14 1.6|
Acinus, Cytomegaly | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 4 1.0|
Duct, Hyperplasia | 1 1 1 1 2 1 3 1 1| 19 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| |
DAY ON TEST | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3| |
| 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | 2 4 | 8 2.5|
Inflammation | 2 4 | 8 2.4|
Ulcer | 2 | 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 4.0|
Inflammation | | 2 1.5|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | +| 1 |
Inflammation, Chronic | 2| 1 2.0|
Inflammation, Suppurative | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Inflammation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 1 1 2 1 2 1 1 2 3 1 1 1 1 2 1 2 1 3| 37 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration, Cystic | 3| 1 3.0|
Degeneration, Fatty | 1 2 1 2 1 2 2 3 1 3 2 2 1 1 1 1| 28 1.7|
Degeneration | | 1 3.0|
Focal Cellular Change | 2 | 3 2.0|
Hematopoietic Cell Proliferation | 1 1 1 1 | 10 1.2|
Hyperplasia | 2 2 2 3 2 | 11 2.1|
Hypertrophy | 2 | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 2 2 1 2 2 | 11 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + M + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M + + + M + + + M + M M + M + + + + + +| 38 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Degeneration, Cystic | 3 | 2 2.5|
Pars Distalis, Hyperplasia | 3 4 2 4 | 7 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| |
DAY ON TEST | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3| |
| 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + + + + + + + M + + + + + + + +| 45 |
C-Cell, Hyperplasia | 2 2 2 4 4 3 2 1 2 1 2 3| 21 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + + M + + + + + + + + + + + + +| 42 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 1 1 1 1| 7 1.3|
__________________________________________________________________________|____________|
Ovary | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 2 2 | 6 2.3|
Cyst | | 1 |
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + A + + + + + + + + + + + + + + + + + + + + M +| 48 |
Endometrium, Cyst | | 1 |
Endometrium, Inflammation, | | |
Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | I + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Myelofibrosis | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesenteric, Inflammation, | | |
Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + A + + + M + + + + M M + + + + + + + + + + + +| 41 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | | 2 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + A + I + + + + + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 3 2 2 2 2 2 2 3 | 17 2.2|
__________________________________________________________________________|____________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 3 2.3|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| |
DAY ON TEST | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3| |
| 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Focal, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + A + M + + M I + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 1 | 3 1.3|
Hyperplasia | 1 1 1 1 1 | 11 1.3|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + M + + + M + + + + + + + + +| 47 |
Inflammation, Suppurative | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteopetrosis | 4 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 1 3.0|
Hemorrhage | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 2 1.0|
Inflammation, Suppurative | 1 1 1 1 1 1 1 2 2 | 22 1.3|
Metaplasia, Squamous | | 2 1.5|
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 3 1 1 1 1 | 9 1.3|
Metaplasia, Squamous | | 1 1.0|
Pigmentation, Hemosiderin | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 3 1 | 6 1.8|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 2 1 1 1 | 11 1.5|
Bronchiole, Epithelium, Hyperplasia | 2 | 1 2.0|
Bronchus, Mineralization | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| |
DAY ON TEST | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3| |
| 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchus, Epithelium, Hyperplasia | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 2 1 1 1 1 1| 14 1.4|
Pleura, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 1 1.0|
Inflammation | 1 2 2 1 2 1 2 2 2 1 1 2 2 2 1 2 2 2 1 3 1 3| 42 1.8|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.1|
Thrombosis | 2 | 3 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 1 1 | 7 1.4|
Olfactory Epithelium, Degeneration | | 1 1.0|
Olfactory Epithelium, Metaplasia | 2 1 | 3 1.3|
Respiratory Epithelium, Hyperplasia | 1 2 3 2 2 1 3 3 3 3 3 3 2 3 2 3 3 3| 38 2.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 2 2 1 1 2 2 3 1 2| 26 1.7|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 1 1 | 4 1.0|
Epithelium, Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Synechia | 4 3 | 3 3.3|
Lens, Degeneration | 2 3 1 1 3 | 8 2.1|
Lens, Mineralization | 1 3 3 | 4 2.3|
Retina, Atrophy | 3 4 1 4 | 9 2.2|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 8 |
Inflammation, Suppurative | 1 1 | 6 1.0|
Metaplasia, Squamous | 1 | 3 1.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Acinus, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 2 | 2 2.0|
Nephropathy | 1 3 2 1 2 2 3 3 3 2 1 2 3 2 2 3 2 3 3 1 1 2 2 3| 48 2.1|
Papilla, Necrosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 5| 7| |
DAY ON TEST | 1| 3| 9| 3| 7| 3| 7| 3| 3| 3| 0| 1| 3| 3| 3| 3| 7| 3| 3| 8| 6| 8| 3| 4| 3| |
| 6| 6| 7| 6| 5| 6| 5| 6| 6| 6| 5| 0| 6| 6| 6| 6| 2| 6| 6| 7| 6| 6| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|
| 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + A M + + + + A + M + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + A + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + A + + + + + M + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + A + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +|
Angiectasis | 4 1 1 2 |
Basophilic Focus | 1 1 1 1 1 1 1 2 2 2 1 2 |
Clear Cell Focus | 1 |
Congestion | 4 |
Degeneration, Cystic | 2 |
Degeneration, Fatty | 3 3 4 2|
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 |
Necrosis | 3 1 1 |
Bile Duct, Hyperplasia | 1 2 1 1 1 2 1 2 1 2 1 2 2 1 |
Hepatocyte, Hyperplasia, Focal | |
Hepatocyte, Hyperplasia | 1 2 4 |
Hepatocyte, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 3 2 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + A + +|
Acinus, Atrophy | 3 3 1 2 1 2 2 1 1|
Acinus, Cytomegaly | 2 1|
__________________________________________________________________________|
Pharynx | +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + A + +|
Hemorrhage | 3 |
Inflammation | 1 1 1 |
Duct, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + M + + A + +|
Hyperplasia, Squamous | 2 2 4 2 |
Inflammation | 3 3 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|
| 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ectopic Tissue | |
Inflammation | 2 1 2|
Mineralization | 2 3 |
Ulcer | 2 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | 1 2 1 2 2 3 2 2 2 1 3 2 2 3 4 1 2 2 1 2 2 2 2 2|
Mineralization | 3 |
Pigmentation, Hemosiderin | |
Atrium, Thrombosis | 2 2 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + A + + + + + + + A + +|
Degeneration, Fatty | 1 2 1 2 3 2 3 1 1|
Focal Cellular Change | 2 3 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 2 1 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + A + + + + + + + A + +|
Hyperplasia | 1 2 2 2 3 1 2 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Parathyroid Gland | I M + + + M M + + + + + + + + M M + + M + + A + +|
Hyperplasia | 2 2 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A M +|
Pars Distalis, Hyperplasia | 3 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + A + +|
C-Cell, Hyperplasia | 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | M + M + + + + + M + + M + + M + + + M + + + M + +|
Granuloma Sperm | 4 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + M + + + A + +|
Cyst | |
Inflammation, Suppurative | 3 2 3 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | 2 |
Inflammation, Suppurative | 3 4 2 2 3 2 2 1 1|
Epithelium, Hyperplasia | 1 4 1 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|
| 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + |
Hemorrhage | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1|
Perivascular, Inflammation | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + A + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + A + + + + + + + A + +|
Mesenteric, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + A + M + + + + + A + +|
Congestion | 3 |
Hyperplasia | 2 |
Pigmentation, Hemosiderin | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + A + + + + + + + M + +|
Congestion | 4 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 1 2 2 2 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + A + +|
Fibrosis | 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + M + M + + + + A + + M M + + + A M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + M + + + M M + + M M M + M + M M M M|
Galactocele | 2 1 2 |
Hyperplasia | 1 1 2 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst Epithelial Inclusion | X |
Inflammation, Suppurative | 3 |
Prepuce, Inflammation, Suppurative | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + A + +|
Fibrous Osteodystrophy | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | 3 |
Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|
| 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + A + +|
Inflammation, Suppurative | 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | 2 |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Chronic, Focal | 1 2 2 1 1 3 1 |
Metaplasia, Osseous | 1 |
Mineralization | 2 2 |
Pigmentation, Hemosiderin | 2 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 1 1 |
Bronchiole, Epithelium, Hyperplasia | 1 |
Peribronchial, Infiltration Cellular,| |
Mononuclear Cell | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 2 |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + A + + + + + + + A + +|
Foreign Body | 1 1 |
Inflammation | 1 1 1 1 2 2 2 1 1 2 1 1 2 1 3 1|
Inflammation, Suppurative | 1 1 1 1 1 2 1 1 1 2 1 2 3 1|
Thrombosis | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 1 |
Olfactory Epithelium, Degeneration | 1 1 3 |
Olfactory Epithelium, Metaplasia | 2 2 2 |
Respiratory Epithelium, Hyperplasia | 1 2 1 3 2 1 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + A + +|
Inflammation | |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | 2 |
Epithelium, Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 4| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 6| 7| 5| 7| 6| 4| 7| 7|
DAY ON TEST | 2| 7| 0| 5| 7| 3| 0| 3| 3| 3| 2| 2| 3| 0| 7| 1| 3| 0| 0| 8| 1| 0| 5| 3| 3|
| 7| 7| 5| 0| 2| 5| 7| 5| 3| 5| 1| 1| 5| 5| 1| 8| 5| 2| 6| 3| 4| 2| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Suppurative | 2 1 |
Cornea, Inflammation, Suppurative | 1 1 |
Lens, Degeneration | 1 2 3 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Cyst | 2 |
Mineralization | 3 2 |
Nephropathy | 1 2 1 1 3 4 2 3 3 3 4 3 3 2 4 3 2 4 3 3 2 3 4|
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X |
Hemorrhage | 3 |
Inflammation, Suppurative | 1 2 |
Mineralization | 2 |
Transitional Epithelium, Hyperplasia | 2 4 1 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5| |
DAY ON TEST | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7| |
| 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + I + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + A + + + + + + + + A + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + M + + + + + + A + A + + + + + + + M +| 40 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + A + + + + A + + + A + + + + + + + + +| 44 |
Parasite Metazoan | X X X X X | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M M A + M + + + + A + + + A + + + M + + + A +| 40 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + A + + + + + + + + A + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + A + + + + A + + + A + + + + + + + A +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + + + + A + + + A + + + + + + + A +| 41 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + A + + + + + + + + A + + + + + + + A +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 4 2.0|
Basophilic Focus | 1 1 2 1 1 2 2 1 2 1| 22 1.4|
Clear Cell Focus | | 1 1.0|
Congestion | | 1 4.0|
Degeneration, Cystic | 1 | 2 1.5|
Degeneration, Fatty | 3 2 | 6 2.8|
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1| 12 1.0|
Necrosis | 2 4 1 1 1 | 8 1.8|
Bile Duct, Hyperplasia | 2 2 2 1 2 2 1 1 1 1 2 1 2 1 1 1 1 1| 32 1.4|
Hepatocyte, Hyperplasia, Focal | 2 | 1 2.0|
Hepatocyte, Hyperplasia | 1 | 4 2.0|
Hepatocyte, Necrosis | 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Inflammation, Chronic | | 2 2.5|
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Acinus, Atrophy | 4 1 1 2 2 3 1 1 1| 18 1.8|
Acinus, Cytomegaly | | 2 1.5|
__________________________________________________________________________|____________|
Pharynx | + +| 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + A + A + + + + + + + + + + + + + + + + + +| 46 |
Hemorrhage | | 1 3.0|
Inflammation | 1 | 4 1.0|
Duct, Hyperplasia | 1 1 1 1 2 2 1 1 | 11 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5| |
DAY ON TEST | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7| |
| 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Squamous | 3 2 | 6 2.5|
Inflammation | 3 2 | 4 2.8|
Ulcer | 4 2 | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Ectopic Tissue | X | 1 |
Inflammation | 1 | 4 1.5|
Mineralization | | 2 2.5|
Ulcer | | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 2 1 2 1 2 3 2 1 1 3 2 2 2 1 2 2 2 2 1 3 3 2| 47 2.0|
Mineralization | | 1 3.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Atrium, Thrombosis | 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Degeneration, Fatty | 1 2 1 1 2 1 3 2 1 1| 19 1.6|
Focal Cellular Change | | 3 2.0|
Hematopoietic Cell Proliferation | 1 2 | 2 1.5|
Hyperplasia | 2 2 2 | 6 2.0|
Hypertrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + A + + + + + + + + + + M + + + + + + + + +| 46 |
Hyperplasia | 2 2 1 2 3 2 1 3 4 3 2 | 20 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + M + + + M M I + M + + + + + + + +| 35 |
Hyperplasia | 2 | 4 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 2 4 2 4 | 7 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + M + + + + + + + + + + + + + + + + A +| 45 |
C-Cell, Hyperplasia | 2 2 2 2 3 2 1 1| 11 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5| |
DAY ON TEST | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7| |
| 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + M M + + + + + + + + M +| 40 |
Granuloma Sperm | | 1 4.0|
Vacuolization Cytoplasmic | 2 2 2 2 2 3 2 | 8 2.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + A + + + + + + + + + + + + + + + + + M M +| 45 |
Cyst | 2 | 1 2.0|
Inflammation, Suppurative | 1 3 1 2 2 3 1 2 1 | 17 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | 2 3 2 2 1 2 2 1 1| 18 2.0|
Epithelium, Hyperplasia | 2 2 1 | 7 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 3 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 3 | 8 2.9|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 | 13 1.0|
Perivascular, Inflammation | 2 3 1 | 5 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + A + + + + + + + + + + + + + + + + + +| 46 |
Myelofibrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mesenteric, Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + + + + + + + + + M +| 44 |
Congestion | | 1 3.0|
Hyperplasia | 1 | 2 1.5|
Pigmentation, Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + I + + + + + + + + + +| 45 |
Congestion | | 1 4.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2| 16 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | 1 2 1 | 6 1.7|
__________________________________________________________________________|____________|
Thymus | + M M M M + I + + + + + + + + M + + + + M M + + M| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M A M M + M M + + + M + M + M + M + M M + M| 23 |
Galactocele | 2 1 1 2 | 7 1.6|
Hyperplasia | 2 2 2 1 | 10 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5| |
DAY ON TEST | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7| |
| 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + I M + + + + I + + + + + + + + + + +| 46 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Suppurative | | 1 3.0|
Prepuce, Inflammation, Suppurative | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + A + A + + + + + + + + + + + + + + + + + +| 47 |
Fibrous Osteodystrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 1 1 1 1 1 2 1 | 15 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 1 | 2 1.5|
Inflammation, Chronic, Diffuse | | 1 3.0|
Inflammation, Chronic, Focal | 2 1 2 2 2 1 | 13 1.6|
Metaplasia, Osseous | | 1 1.0|
Mineralization | | 2 2.0|
Pigmentation, Hemosiderin | | 3 1.3|
Alveolar Epithelium, Hyperplasia | 4 2 | 5 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 2 1 1 | 11 1.3|
Bronchiole, Epithelium, Hyperplasia | | 1 1.0|
Peribronchial, Infiltration Cellular,| | |
Mononuclear Cell | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 2 1| 9 1.2|
__________________________________________________________________________|____________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
Foreign Body | 1 | 3 1.0|
Inflammation | 1 1 1 1 1 2 1 2 2 2 1 2 1 1 | 30 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 6| 4| 7| 6| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 4| 5| |
DAY ON TEST | 0| 2| 5| 3| 5| 0| 4| 3| 8| 5| 5| 1| 3| 3| 6| 5| 3| 2| 3| 1| 1| 5| 3| 4| 7| |
| 0| 2| 8| 5| 6| 2| 7| 5| 7| 9| 9| 7| 5| 5| 6| 2| 5| 2| 5| 9| 5| 9| 5| 2| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 1 1 1 1 3 2 1 1 1 1 1 1 | 26 1.3|
Thrombosis | 2 2 2 2 1 1 | 7 1.9|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 1 2 2 1 1 | 9 1.2|
Olfactory Epithelium, Degeneration | 2 | 4 1.8|
Olfactory Epithelium, Metaplasia | 1 | 4 1.8|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 | 12 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.0|
Vomeronasal Organ, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + A + A + + + + + + + + + + + + + + + + + +| 46 |
Inflammation | 2 | 1 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
Epithelium, Metaplasia, Squamous | 1 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Anterior Chamber, Inflammation, | | |
Suppurative | | 2 1.5|
Cornea, Inflammation, Suppurative | | 2 1.0|
Lens, Degeneration | 2 1 1 | 6 1.7|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Mineralization | | 2 2.5|
Nephropathy | 4 2 3 3 1 2 1 3 3 3 3 2 2 3 2 1 3 2 3 2 3 2 3 2 2| 48 2.6|
Renal Tubule, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Gross Observation | | 2 |
Calculus Micro Observation Only | | 2 |
Hemorrhage | 2 | 2 2.5|
Inflammation, Suppurative | 2 | 3 1.7|
Mineralization | | 1 2.0|
Transitional Epithelium, Hyperplasia | 3 | 5 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|
| 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M I + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + I + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + M + + A + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | I + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + A + +|
Hyperplasia, Lymphoid | 2 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A A + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 |
Basophilic Focus | 1 2 X 1 1 1 1 1 |
Degeneration, Cystic | 1 2 2 2 |
Degeneration, Fatty | 2 |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | 2|
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 |
Leukocytosis | 2 |
Necrosis | 3 1 1 2 1 1 |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 2 1 2 3 2 1 2 2 1 1 2 1 2 2 1|
Hepatocyte, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation | 1 2 2 |
Duct, Hyperplasia | 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 |
Inflammation | 2 2 1 |
Ulcer | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|
| 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ectopic Tissue | X |
Erosion | 3 |
Inflammation | 2 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 2 2 2 2 1 1 1 1 2 2 3 1 3 2 2 1 2|
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 2 1 1 2 2 1 2 2 2 1 2 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 3 3 1 4 3 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + M + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + I + + + + + + + + A + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + I + + M + + I + + + + + + M + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 |
Inflammation, Suppurative | 1 1 3 1 1 1 4 2 3 2|
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 4 1 2 2 1 1 1 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|
| 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 1 2 4 4 |
Interstitial Cell, Hyperplasia | 1 3 1 1 2 |
Perivascular, Inflammation | 1 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + + + + + + + + M + + + M + + + + +|
Angiectasis | |
Hyperplasia | 2 3 2 3 2 2 1 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis | 2 1 3 |
Hematopoietic Cell Proliferation | 2 2|
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + M M + + M + + M + M M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + + + M + + M M + M + M M + M M + M M M +|
Galactocele | 1 4 1 |
Hyperplasia | 2 2 1 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Prepuce, Inflammation, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Chronic | 4 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 |
Hemorrhage | 1 2 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|
| 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 2 1 2 4 1 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 2 3 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic, Focal | 3 1 2 1 1 2 1 |
Leukocytosis | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 1 4 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 3 1 |
Bronchiole, Inflammation, Suppurative| |
Bronchiole, Epithelium, Hyperplasia | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 |
Inflammation | 2 1 1 2 2 3 2 2 2 1 1 2 2 2 2 2|
Inflammation, Suppurative | 1 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1 2 4 1 1|
Thrombosis | 2 3 1 |
Mucosa, Cyst | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 2 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 2 2 1 1 2 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 |
Epithelium, Hyperplasia | 1 |
Epithelium, Metaplasia, Squamous | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 6| 5| 7| 6| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 4| 0| 7| 3| 3| 3| 6| 5| 3| 8| 3| 3| 3| 0| 0| 3| 7| 3| 1| 6| 3| 3| 0| 1| 0|
| 0| 2| 9| 7| 7| 7| 6| 6| 7| 7| 7| 1| 7| 2| 6| 1| 7| 7| 6| 8| 7| 7| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 3 2 2 3 2 3 2 2 3 3 2 2 3 2 2 2 3 2 2 3 3 3 2 2|
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Transitional Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3| |
| 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M + + + + + + M + + + + + I + + + + + A + +| 44 |
Parasite Metazoan | X X X| 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + A + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Parasite Metazoan | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + M + + A + M + + + + I + + +| 42 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + I A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + A + + + + A + + + + +| 45 |
Hyperplasia, Lymphoid | 2 2 2 3 1 | 7 2.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + A + + + + + + + A + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 1| 7 1.4|
Basophilic Focus | 1 1 1 X 1 2 2 1 1 1| 18 1.2|
Degeneration, Cystic | 2 2 1 | 7 1.7|
Degeneration, Fatty | 2 1 | 3 1.7|
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | 1 1 2 1 | 5 1.4|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 2 2 1 1 | 19 1.1|
Leukocytosis | | 1 2.0|
Necrosis | 3 3 | 8 1.9|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 2 2 2 1 1 1 1 1 1 1 1 1 2 1 1| 32 1.4|
Hepatocyte, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Inflammation, Chronic | 2 | 2 2.5|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 3 1 2 2 1 1 | 15 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 2 1 | 6 1.5|
Duct, Hyperplasia | 1 1 1 1 2 2 1 1| 16 1.2|
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3| |
| 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 2 1 | 4 2.0|
Inflammation | | 3 1.7|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | | 1 |
Erosion | | 1 3.0|
Inflammation | 1 2 2 | 5 1.8|
Ulcer | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 1 1 1 2 3 1 1 2 1 2 2 2 2 1 2 3 2 1 2 3 2 1 2| 44 1.7|
Atrium, Thrombosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 1 1 1 1 1 1 2 1 1 2 1 2 2 1 2 1 1 | 30 1.4|
Focal Cellular Change | 1 1 | 3 1.3|
Hematopoietic Cell Proliferation | 1 1 2 | 3 1.3|
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 2 2 1 2| 15 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + M M I + + M + M + M M + + M + I + M + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 3 1 2 3 1 2 3 | 10 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + A + + + + + + + + + +| 46 |
C-Cell, Hyperplasia | 2 3 2 1 | 5 1.8|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + M + + + M M + + M + + + M + + M + M + + M I| 36 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3| |
| 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Cyst | X X | 2 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 2 2 1 1 2| 15 1.8|
Duct, Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 2 1 1 2 2 2 1 2 1 1 2 2 2 | 23 1.7|
Epithelium, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
Inflammation, Suppurative | 1 | 3 1.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 4 2 2 3 | 11 3.1|
Interstitial Cell, Hyperplasia | 2 2 2 2 | 9 1.8|
Perivascular, Inflammation | | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 3 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Congestion | 3 | 1 3.0|
Inflammation, Granulomatous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M M + M + + + + + + + + + +| 43 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 3 2 2 2 3 2 2 1 2| 16 2.1|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectopic Tissue | X| 1 |
Fibrosis | 2 1 3 1 2 | 8 1.9|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Necrosis | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thymus | M + + A + + + + + + + + + + A + + + + + + + + + M| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + M I M M M + + M + M M M + + M M + M M + M| 20 |
Galactocele | 2 | 4 2.0|
Hyperplasia | 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3| |
| 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | 3 2 | 2 2.5|
Prepuce, Inflammation, Suppurative | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 2.5|
Hemorrhage | 2 2 2 2 | 7 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 1 1 1 1 1 | 14 1.4|
Metaplasia, Squamous | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 3 3.0|
Hemorrhage | 1 1 | 5 1.8|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic, Focal | 3 2 1 1 1 1 | 13 1.5|
Leukocytosis | 3 2 | 2 2.5|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 5 2.2|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 | 7 1.4|
Bronchiole, Inflammation, Suppurative| 1 | 1 1.0|
Bronchiole, Epithelium, Hyperplasia | 1 | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 2 1.0|
Inflammation | 2 1 2 2 1 1 1 2 2 2 1 1 3 2 2 2 2 2| 34 1.8|
Inflammation, Suppurative | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1| 36 1.3|
Thrombosis | | 3 2.0|
Mucosa, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 2| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 6| 5| 7| 7| 7| 6| 7| 7| 5| 7| 7| |
DAY ON TEST | 7| 0| 3| 6| 0| 3| 3| 3| 6| 3| 4| 3| 3| 3| 7| 5| 3| 3| 3| 3| 3| 3| 9| 3| 3| |
| 0| 6| 1| 1| 5| 7| 7| 7| 1| 7| 9| 7| 1| 7| 2| 9| 7| 7| 7| 9| 7| 7| 6| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 2| 5 1.8|
Olfactory Epithelium, Metaplasia | 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia | 2 1 1 1 2 2 1 2| 17 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 1| 11 1.3|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 1 | 6 1.2|
Epithelium, Hyperplasia | | 1 1.0|
Epithelium, Metaplasia, Squamous | 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy | 2 2 2 2 3 2 2 1 3 3 2 3 3 3 2 2 2 2 3 3 2 2 3 4| 49 2.4|
Renal Tubule, Hyperplasia | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.5|
Transitional Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|
| 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anus, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + A + + + + + A A + A + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + A + A + + + + +|
Diverticulum | 3 |
Inflammation | 2 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + M + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + A + + + + + A + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + + + A + + + + + A A + A + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Basophilic Focus | 2 2 2 2 2 1 2 2 2 2 |
Degeneration, Cystic | 1 1 1 2 |
Degeneration, Fatty | 3 1 1 |
Degeneration | |
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 |
Leukocytosis | |
Necrosis | 2 1 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 1 2 2 1 1 1 3 2 3 1 2 2 1 1|
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic | 3 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Acinus, Atrophy | 3 3 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 1 |
Necrosis | 2 |
Duct, Hyperplasia | 1 1 1 2 2 1 2 1 2|
Duct, Inflammation, Suppurative | 1 |
Duct, Metaplasia, Squamous | 1 |
Parotid Gland, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|
| 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 3 |
Inflammation | 2 3 |
Mineralization | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation | |
Mineralization | 3 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | |
Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 2 3 2 2 3 3 2 2 2 3 2 3 2 3 2 2 2|
Mineralization | 3 3 |
Atrium, Thrombosis | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 4 2 2 2|
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 2|
Inflammation, Chronic | 3 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 3 |
Thrombosis | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 2 3 2 |
Inflammation, Chronic | 3 |
Necrosis | 3 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + I +|
Cytomegaly | 1 |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + I + + + + + + + +|
Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|
| 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 2 3 2 3 |
Pars Intermedia, Degeneration, Cystic| |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | A + + + + + M + + + + M M + + M + + M + M + + + +|
Inflammation, Chronic | 4 |
Mineralization | 3 |
Necrosis | 4 |
Vacuolization Cytoplasmic | 3 2 2 2 |
Serosa, Hyperplasia | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 1 2 2 3 2 2 1 1 3 1 2|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + M + + + + +|
Inflammation, Suppurative | 1 2 2 2 2 |
Epithelium, Hyperplasia | 4 3 1 1 3 1|
__________________________________________________________________________|
Seminal Vesicle | + |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 4 4 4 3 4 |
Mineralization | 3 |
Interstitial Cell, Hyperplasia | 1 2 3 1 |
Perivascular, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | A + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|
| 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + M + + + + + + + + + M + + + +|
Angiectasis | |
Hyperplasia | 2 1 2 2 2 2 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 1 3 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | A + + + + + + + + + M + + + + + M M + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + + + + M M + + M M + M M + M + + + + M|
Galactocele | 1 2 1 |
Hyperplasia | 2 2 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 4 |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 2 2 1 2 1 1 2 |
Metaplasia, Squamous | 1 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 4 3 3|
Foreign Body | |
Hemorrhage | 3 2 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | 2 1 |
Inflammation, Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|
| 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukocytosis | X |
Mineralization | 1 |
Pigmentation, Hemosiderin | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 2 1 2 3 |
Alveolus, Inflammation, Suppurative | 2 |
Artery, Intima, Inflammation, Chronic| |
Bronchiole, Inflammation, Suppurative| |
Bronchiole, Epithelium, Hyperplasia | |
Bronchus, Inflammation, Suppurative | 3 2 |
Bronchus, Epithelium, Hyperplasia | |
Bronchus, Epithelium, Metaplasia, | |
Squamous | |
Peribronchiolar, Infiltration | |
Cellular, Mononuclear Cell | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 2 2 1 2 |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation | 1 2 2 1 1 2 1 2 2 1 2 2 2 1 2 2 2 2 2 1|
Inflammation, Suppurative | 4 1 1 2 1 1 1 1 1 3 1 1 1 1 1 1 2 1 1 1 1 2 1 |
Thrombosis | 2 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 2 2 2 2 2 2 |
Olfactory Epithelium, Degeneration | 1 1 1 |
Olfactory Epithelium, Metaplasia | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 1 1 1 1 1 1 3 1 2 1 2 2 3 2 2 2 2 1 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 1 2 1 1 1 1 3 1 1 2|
Vomeronasal Organ, Inflammation, | |
Suppurative | 2 2 2 1 |
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Inflammation, Suppurative | 1 |
Mineralization | 2 |
Epithelium, Metaplasia, Squamous | 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Synechia | |
Anterior Chamber, Inflammation, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 5| 6| 7| 7| 5| 7| 6| 5| 6| 7| 6| 5| 6| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 3| 3| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 5| 7| 3| 9| 3| 3| 5| 3| 3| 3| 0| 3|
| 6| 6| 6| 8| 1| 6| 0| 2| 6| 6| 9| 6| 6| 9| 5| 6| 9| 2| 8| 8| 6| 6| 6| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Hyperplasia | |
Cornea, Inflammation, Suppurative | 2 |
Cornea, Mineralization | 1 1 |
Lens, Degeneration | 2 2 1 |
Lens, Mineralization | |
Retina, Atrophy | |
Sclera, Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hydronephrosis | 3 |
Nephropathy | 3 3 3 3 3 3 1 3 3 4 4 4 3 2 2 3 3 4 2 3 3 4 3 3|
Pelvis, Inflammation, Suppurative | 2 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3| |
| 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Anus, Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + M + + + M + + M + + + I + M + + + + + + + + +| 39 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Diverticulum | | 1 3.0|
Inflammation | | 1 2.0|
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| 47 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + A + + + + + + + A + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + A + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + A + + + + + + + A + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + M + + + + + + + A + + + + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 5 2.0|
Basophilic Focus | 1 2 1 1 2 1 1 1 1 1 1 | 21 1.5|
Degeneration, Cystic | 2 1 3 1 | 8 1.5|
Degeneration, Fatty | 1 3 2 2 3 | 8 2.0|
Degeneration | 4 | 1 4.0|
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | 2 1 2 | 3 1.7|
Hepatodiaphragmatic Nodule | X X X | 4 |
Inflammation, Focal, Granulomatous | 1 1 1 1 1 1 1 1 1 | 16 1.0|
Leukocytosis | X | 1 |
Necrosis | 1 1 2| 5 1.4|
Thrombosis | 2| 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 1 2 3 3 2 3 2| 29 1.7|
Hepatocyte, Hyperplasia | 2 | 1 2.0|
Hepatocyte, Necrosis | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Inflammation, Chronic | 4 3 | 3 3.3|
Fat, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 1 1 | 3 1.3|
Acinus, Atrophy | 3 2 1 1 2 2 4 1 1 1 1 2 2 1 3 1 | 25 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Inflammation | 1 1 | 6 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3| |
| 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | | 1 2.0|
Duct, Hyperplasia | 1 1 1 1 | 13 1.3|
Duct, Inflammation, Suppurative | | 1 1.0|
Duct, Metaplasia, Squamous | | 1 1.0|
Parotid Gland, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 3 4 3 1 4 | 7 2.9|
Inflammation | 3 3 1 4 | 6 2.7|
Mineralization | 2 | 1 2.0|
Ulcer | 1 4 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 2.0|
Inflammation | 2 | 1 2.0|
Mineralization | 4 | 3 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 4 |
Inflammation | 3 2 | 2 2.5|
Mineralization | 3 | 2 3.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 2 2 2 1 4 2 2 2 1 4 2 1 2 2 1 1 1 2 | 41 2.0|
Mineralization | 3 | 3 3.0|
Atrium, Thrombosis | 2 3 | 4 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 2 2 2 1 2 1 3 2 2 2 1 2 1 | 18 1.9|
Focal Cellular Change | 1 2 1 | 3 1.3|
Hematopoietic Cell Proliferation | 1 2 | 3 1.3|
Hyperplasia | 2 | 3 2.0|
Inflammation, Chronic | | 1 3.0|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3| |
| 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 2 2 2 3 2 2 2 | 14 2.1|
Inflammation, Chronic | | 1 3.0|
Necrosis | | 1 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cytomegaly | | 1 1.0|
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + M + + + + M + + + M + + + + +| 44 |
Hyperplasia | 4 2 | 4 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 48 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 | 6 2.5|
Pars Intermedia, Degeneration, Cystic| 2 | 1 2.0|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 2 4 2 2 1 1 | 10 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + M + + + + + + + + + M I + + + + + + + M + + +| 39 |
Inflammation, Chronic | | 1 4.0|
Mineralization | | 1 3.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | | 4 2.3|
Serosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Suppurative | 1 4 3 1 2 3 2 2 2 2 1 1| 23 1.9|
Duct, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Suppurative | 2 2 2 2 1 2 1 2 1 2 | 15 1.7|
Epithelium, Hyperplasia | 1 1 1 | 9 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 2 |
Inflammation, Suppurative | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3| |
| 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 1 4 1 1 4 | 14 3.0|
Mineralization | | 1 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 | 12 1.3|
Perivascular, Inflammation | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Cellular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + M M + + + + + + +| 46 |
Angiectasis | 3 | 2 2.5|
Hyperplasia | | 1 2.0|
Inflammation, Granulomatous | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + M + + +| 45 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 3 | 15 2.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Developmental Malformation | X | 1 |
Fibrosis | 2 3 3 2 | 8 2.3|
Hematopoietic Cell Proliferation | 3 2 | 3 2.3|
Hemorrhage | | 1 4.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M M + + + + + + M + + + + + + + M + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M M I + I M + + + + + M M M + I M + M + M| 23 |
Galactocele | 1 1 1 2 2 2 1 | 10 1.4|
Hyperplasia | 1 2 2 2 | 8 1.9|
__________________________________________________________________________|____________|
Skin | M + + + + M + + + + + + + + + + M + + + + + + + +| 47 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 | 1 4.0|
Subcutaneous Tissue, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3| |
| 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hyperostosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 3 | 2 3.5|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 2 1 1 1 1 1 2| 21 1.3|
Metaplasia, Squamous | 1 | 3 1.7|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 4 3.5|
Foreign Body | 1 | 1 1.0|
Hemorrhage | 2 1 2 1 | 7 1.9|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Inflammation, Chronic, Diffuse | 3 | 1 3.0|
Inflammation, Chronic, Focal | 2 2 2 | 5 1.8|
Inflammation, Focal, Granulomatous | 3 4 | 2 3.5|
Leukocytosis | 2 | 2 2.0|
Mineralization | 4 | 2 2.5|
Pigmentation, Hemosiderin | 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 1 3 3 2 | 6 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 2 | 8 2.0|
Alveolus, Inflammation, Suppurative | | 1 2.0|
Artery, Intima, Inflammation, Chronic| 2 | 1 2.0|
Bronchiole, Inflammation, Suppurative| 2 | 1 2.0|
Bronchiole, Epithelium, Hyperplasia | 2 1 | 2 1.5|
Bronchus, Inflammation, Suppurative | | 2 2.5|
Bronchus, Epithelium, Hyperplasia | 2 | 1 2.0|
Bronchus, Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
Peribronchiolar, Infiltration | | |
Cellular, Mononuclear Cell | 2 | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 2 2 1 2 1 | 13 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3| |
| 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 1 1 | 3 1.0|
Inflammation | 1 1 3 2 1 1 1 3 2 2 2 2 3 2 2 1 3 3 2 2 2 2 2 2| 44 1.8|
Inflammation, Suppurative | 1 3 1 1 1 2 1 1 2 1 2 1 1 1 1 1 2 1 2 1 1 1 2| 46 1.3|
Thrombosis | 2 3| 5 2.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 2 1 2 1 2 | 14 1.8|
Olfactory Epithelium, Degeneration | 1 2 1 | 6 1.2|
Olfactory Epithelium, Metaplasia | 1 2 1 1 1 | 7 1.4|
Respiratory Epithelium, Hyperplasia | 1 2 3 1 2 1 1 3 2 1 2 1 3 1 1 2 2 1 2 2 1 1 2| 44 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 1 2 2 3 1 2 2 3 2 2 2 2 3| 27 1.8|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
Inflammation, Suppurative | 2 1 1 1| 5 1.2|
Mineralization | 2 | 2 2.0|
Epithelium, Metaplasia, Squamous | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Synechia | 2 | 1 2.0|
Anterior Chamber, Inflammation, | | |
Suppurative | 2 | 2 2.0|
Cornea, Hyperplasia | 2 | 1 2.0|
Cornea, Inflammation, Suppurative | 1 2 | 3 1.7|
Cornea, Mineralization | 1 | 3 1.0|
Lens, Degeneration | 3 4 2 3 | 7 2.4|
Lens, Mineralization | 2 2 | 2 2.0|
Retina, Atrophy | 4 4 | 2 4.0|
Sclera, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hydronephrosis | | 1 3.0|
Nephropathy | 1 3 2 3 3 2 4 3 1 3 3 2 4 4 1 3 3 3 2 2 2 1 1 2| 48 2.7|
Pelvis, Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05097-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALPHA-CHLOROACETOPHENONE Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:03:48
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 7| 7| 7| 4| 7| 7| 4| 7| 5| 5| 7| 7| 4| 5| 6| 6| 5| 6| 6| 6| 6| 6| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 8| 1| 3| 9| 3| 2| 4| 3| 0| 4| 9| 6| 8| 9| 9| 9| 9| 3| 3| |
| 4| 6| 8| 6| 6| 6| 6| 6| 6| 3| 6| 7| 0| 6| 6| 4| 8| 9| 6| 5| 4| 4| 4| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Inflammation, | | |
Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
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