Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/874

TDMS Study 05097-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/13/94   
EXP: 05097                ALPHA-CHLOROACETOPHENONE             TIME: 06:34:37   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55107    
CONT: N01-ES-38061                                             CAS: 532-27-4    
PATHOLOGIST: R. MILLER                                                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/13/94  
EXP: 05097                ALPHA-CHLOROACETOPHENONE             TIME: 06:34:37  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55107   
CONT: N01-ES-38061                                             CAS: 532-27-4   
PATHOLOGIST: R. MILLER                                                         

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      318   427   442   447   456   457   577   577   583   602                 |
 |      602   602   605   605   617   619   650   652   658   659                 |
 |      659   659   666   671   672   687   700   706   707   714                 |
 |      715   721   721   722   722   733                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      261   449   505   540   556   559   561   568   570   577                 |
 |      596   605   617   631   631   639   666   672   679   687                 |
 |      700   702   702   706   706   716   731   731                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      318   444   486   493   527   532   534   539   540   540                 |
 |      546   559   595   598   605   612   630   630   638   638                 |
 |      658   669   675   686   686   694   694   694   699   706                 |
 |      716   731   731                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.0  98.0  88.0  88.0  72.0  56.0  28.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1 MG/M3    |   100.0 100.0  98.0  98.0  98.0  96.0  92.0  76.0  68.0  44.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2 MG/M3    |   100.0 100.0 100.0  98.0  98.0  96.0  80.0  70.0  58.0  34.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          1 MG/M3          2 MG/M3       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       28.0%            44.0%            34.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.815N         P=0.183N         P=0.851N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       620.3            616.5            607.4         |
 |NATURAL DEATHS (C)      |       (17.0)           (19.2)           (16.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       652.4            668.7            650.8         |
 |(STANDARD ERROR)        |       (14.2)           (13.6)           (13.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      48    477   533   570   573   577   577   587   594   597                 |
 |      602   602   609   633   651   654   658   659   659   679                 |
 |      679   687   687   700   700   731   731                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 1 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      519   553   560   605   610   616   616   626   631   637                 |
 |      638   640   647   647   658   658   666   671   679   679                 |
 |      687   687   687   694   700   707   707   713   731   731                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      258   477   490   497   505   512   514   523   549   575                 |
 |      610   610   612   666   672   675   682   682   686   686                 |
 |      687   700   700   705   716   731                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                             ALPHA-CHLOROACETOPHENONE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 735 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   735 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.0  98.0  98.0  98.0  98.0  96.0  94.0  76.0  62.0  46.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1 MG/M3    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  92.0  68.0  40.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2 MG/M3    |   100.0 100.0  98.0  98.0  98.0  96.0  84.0  80.0  74.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          1 MG/M3          2 MG/M3       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       46.0%            40.0%            48.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.874N         P=0.932          P=0.945N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       609.4            653.3            604.6         |
 |NATURAL DEATHS (C)      |       (24.6)           ( 9.4)           (21.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       667.2            686.0            667.2         |
 |(STANDARD ERROR)        |       (15.9)           ( 8.0)           (14.5)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                      ALPHA-CHLOROACETOPHENONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        1 MG/M3          = 2
                                                        2 MG/M3          = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                         2        1
      |                                           2        1               1  3 2
      |                                                                    1  1 2    33 2     2
      |                                                                       1  1    3     3 2 2
   90 +
      |                                                                          1          33  22 1
      |                                                                                      33  2211
      |                                                                                           221  1
P  80 +                                                                                            2   2
E     |                                                                                       3 3      22
R     |                                                                                         3     311 2 2
C     |                                                                                                31 1
E  70 +                                                                                                 33  22
N     |                                                                                                  313 21   2
T     |                                                                                                    3 311  22
      |                                                                                                        1 1 2 2
S  60 +                                                                                                      3 3     22
U     |                                                                                                        3  3   22
R     |                                                                                                          1133
V     |
I  50 +                                                                                                           1 3132 2
V     |                                                                                                              11  2  2
A     |                                                                                                               11    2
L     |                                                                                                               311
   40 +                                                                                                                311
      |                                                                                                                  3  3
      |                                                                                                                  11 3
      |
   30 +                                                                                                                   1 1
      |                                                                                                                     1
      |
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.

                                                      ALPHA-CHLOROACETOPHENONE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        1 MG/M3          = 2
                                                        2 MG/M3          = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1       1                                3                                         2
      |         1                                3                                  1      2   2
      |                                                                             133      1 22 1     2
      |                                                                               3 3               22
P  90 +                                                                                 33        11
E     |
R     |                                                                                  3 3   3   11 1  2 22
C     |                                                                                        3   3  11
E  80 +                                                                                            3     3  22
N     |
T     |                                                                                                113  122   3
      |                                                                                                     1 12
S  70 +                                                                                                       11  33
U     |                                                                                                        2  233
R     |                                                                                                        1 122
V     |                                                                                                          1 1
I  60 +                                                                                                            232
V     |                                                                                                            1 13
A     |                                                                                                              113
L     |                                                                                                                3 3
   50 +                                                                                                               12 3  1
      |                                                                                                                     3
      |                                                                                                                22   1
      |
   40 +                                                                                                                     2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 21 obs hidden.

--multipart-boundary
Content-type: text/plain
Range: bytes 26059-26059/26059


--multipart-boundary--