TDMS Study 05097-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05097 ALPHA-CHLOROACETOPHENONE TIME: 06:34:37
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55107
CONT: N01-ES-38061 CAS: 532-27-4
PATHOLOGIST: R. MILLER
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05097 ALPHA-CHLOROACETOPHENONE TIME: 06:34:37
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55107
CONT: N01-ES-38061 CAS: 532-27-4
PATHOLOGIST: R. MILLER
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 318 427 442 447 456 457 577 577 583 602 |
| 602 602 605 605 617 619 650 652 658 659 |
| 659 659 666 671 672 687 700 706 707 714 |
| 715 721 721 722 722 733 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 261 449 505 540 556 559 561 568 570 577 |
| 596 605 617 631 631 639 666 672 679 687 |
| 700 702 702 706 706 716 731 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 318 444 486 493 527 532 534 539 540 540 |
| 546 559 595 598 605 612 630 630 638 638 |
| 658 669 675 686 686 694 694 694 699 706 |
| 716 731 731 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 88.0 88.0 72.0 56.0 28.0 |
| | |
| | |
|1 MG/M3 | 100.0 100.0 98.0 98.0 98.0 96.0 92.0 76.0 68.0 44.0 |
| | |
| | |
|2 MG/M3 | 100.0 100.0 100.0 98.0 98.0 96.0 80.0 70.0 58.0 34.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1 MG/M3 2 MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 28.0% 44.0% 34.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.815N P=0.183N P=0.851N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 620.3 616.5 607.4 |
|NATURAL DEATHS (C) | (17.0) (19.2) (16.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 652.4 668.7 650.8 |
|(STANDARD ERROR) | (14.2) (13.6) (13.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 48 477 533 570 573 577 577 587 594 597 |
| 602 602 609 633 651 654 658 659 659 679 |
| 679 687 687 700 700 731 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 519 553 560 605 610 616 616 626 631 637 |
| 638 640 647 647 658 658 666 671 679 679 |
| 687 687 687 694 700 707 707 713 731 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 258 477 490 497 505 512 514 523 549 575 |
| 610 610 612 666 672 675 682 682 686 686 |
| 687 700 700 705 716 731 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALPHA-CHLOROACETOPHENONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 735 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 735 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 98.0 98.0 98.0 96.0 94.0 76.0 62.0 46.0 |
| | |
| | |
|1 MG/M3 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 68.0 40.0 |
| | |
| | |
|2 MG/M3 | 100.0 100.0 98.0 98.0 98.0 96.0 84.0 80.0 74.0 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1 MG/M3 2 MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 46.0% 40.0% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.874N P=0.932 P=0.945N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 609.4 653.3 604.6 |
|NATURAL DEATHS (C) | (24.6) ( 9.4) (21.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 667.2 686.0 667.2 |
|(STANDARD ERROR) | (15.9) ( 8.0) (14.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALPHA-CHLOROACETOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1 MG/M3 = 2
2 MG/M3 = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 1 1 3 2
| 1 1 2 33 2 2
| 1 1 3 3 2 2
90 +
| 1 33 22 1
| 33 2211
| 221 1
P 80 + 2 2
E | 3 3 22
R | 3 311 2 2
C | 31 1
E 70 + 33 22
N | 313 21 2
T | 3 311 22
| 1 1 2 2
S 60 + 3 3 22
U | 3 3 22
R | 1133
V |
I 50 + 1 3132 2
V | 11 2 2
A | 11 2
L | 311
40 + 311
| 3 3
| 11 3
|
30 + 1 1
| 1
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
ALPHA-CHLOROACETOPHENONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1 MG/M3 = 2
2 MG/M3 = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
| 1 3 1 2 2
| 133 1 22 1 2
| 3 3 22
P 90 + 33 11
E |
R | 3 3 3 11 1 2 22
C | 3 3 11
E 80 + 3 3 22
N |
T | 113 122 3
| 1 12
S 70 + 11 33
U | 2 233
R | 1 122
V | 1 1
I 60 + 232
V | 1 13
A | 113
L | 3 3
50 + 12 3 1
| 3
| 22 1
|
40 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.
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