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https://ntp.niehs.nih.gov/go/876

TDMS Study 05098-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           P-NITROPHENOL


NTP Experiment-Test: 05098-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37




       Facility:  Hazleton, Maryland

       Chemical CAS #:  100-02-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           27           22           25                                     
    Natural Death                                      5            7            5            7                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           26           33           27                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (59)         (59)         (59)                                   
      Amyloid Deposition                                            2 (3%)       3 (5%)       1 (2%)                                
   Gallbladder                                        (53)         (53)         (56)         (54)                                   
      Cyst                                                                       1 (2%)                                             
   Intestine Large, Cecum                             (57)         (56)         (59)         (56)                                   
      Amyloid Deposition                                                         1 (2%)       1 (2%)                                
      Polyarteritis                                    1 (2%)                                                                       
   Intestine Large, Colon                             (56)         (56)         (58)         (57)                                   
      Amyloid Deposition                               1 (2%)                    1 (2%)       1 (2%)                                
      Edema                                            2 (4%)                    3 (5%)                                             
      Polyarteritis                                                                           1 (2%)                                
   Intestine Large, Rectum                            (57)         (55)         (54)         (59)                                   
      Amyloid Deposition                                                         1 (2%)       1 (2%)                                
   Intestine Small, Duodenum                          (58)         (56)         (57)         (53)                                   
      Amyloid Deposition                              24 (41%)     23 (41%)     16 (28%)     19 (36%)                               
   Intestine Small, Ileum                             (57)         (57)         (60)         (56)                                   
      Amyloid Deposition                              37 (65%)     45 (79%)     41 (68%)     38 (68%)                               
      Edema                                                                      2 (3%)                                             
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Mucosa, Inflammation, Focal                                   1 (2%)                                                          
   Intestine Small, Jejunum                           (55)         (54)         (56)         (55)                                   
      Amyloid Deposition                              25 (45%)     30 (56%)     20 (36%)     28 (51%)                               
   Liver                                              (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                              30 (50%)     37 (62%)     27 (45%)     33 (55%)                               
      Angiectasis, Focal                               1 (2%)       1 (2%)                                                          
      Clear Cell Focus                                                                        1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Inflammation, Chronic, Focal                    24 (40%)     21 (35%)     24 (40%)     24 (40%)                               
      Necrosis                                         2 (3%)                                 1 (2%)                                
      Necrosis, Focal                                  1 (2%)       2 (3%)       6 (10%)      3 (5%)                                
      Centrilobular, Hypertrophy                                                              1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (1)                       (2)          (1)                                    
      Hemorrhage, Focal                                                                       1 (100%)                              
      Polyarteritis                                                              1 (50%)                                            
   Pancreas                                           (60)         (57)         (60)         (60)                                   
      Edema                                                                      1 (2%)                                             
      Focal Cellular Change                            2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
      Necrosis, Focal                                               1 (2%)                                                          
      Polyarteritis                                                                           1 (2%)                                
      Acinus, Amyloid Deposition                       2 (3%)       1 (2%)       1 (2%)                                             
      Acinus, Hypertrophy, Focal                       2 (3%)       1 (2%)       6 (10%)      1 (2%)                                
      Interlobular, Edema                             15 (25%)     15 (26%)     14 (23%)     15 (25%)                               
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
      Amyloid Deposition                              27 (45%)     29 (49%)     32 (53%)     32 (53%)                               
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Interlobular, Edema                             18 (30%)     21 (36%)      8 (13%)     11 (18%)                               
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Ulcer                                                                                   1 (2%)                                
      Submucosa, Inflammation, Subacute                                                       1 (2%)                                
   Stomach, Glandular                                 (60)         (59)         (60)         (60)                                   
      Amyloid Deposition                               5 (8%)                    1 (2%)       3 (5%)                                
      Necrosis                                         1 (2%)                                                                       
      Epithelium, Vacuolization Cytoplasmic            1 (2%)                                                                       
      Mucosa, Degeneration                                                       2 (3%)                                             
      Mucosa, Necrosis, Focal                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                              37 (62%)     35 (58%)     33 (55%)     31 (52%)                               
      Fibrosis                                                      1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Polyarteritis                                                              3 (5%)       1 (2%)                                
      Atrium, Inflammation, Suppurative                                                       1 (2%)                                
      Atrium, Thrombosis                               6 (10%)      5 (8%)       3 (5%)       3 (5%)                                
      Myocardium, Inflammation, Focal, Suppurative                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (59)         (60)         (60)                                   
      Capsule, Hyperplasia                            56 (93%)     54 (92%)     58 (97%)     55 (92%)                               
      Corticomedullary Junction, Amyloid Deposition   37 (62%)     40 (68%)     31 (52%)     33 (55%)                               
      Corticomedullary Junction, Hemorrhage            2 (3%)       1 (2%)                                                          
      Corticomedullary Junction, Pigmentation         37 (62%)     34 (58%)     38 (63%)     33 (55%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Corticomedullary Junction, Vacuolization                                                                                      
          Cytoplasmic                                  6 (10%)      9 (15%)      5 (8%)       6 (10%)                               
   Adrenal Gland, Cortex                              (60)         (59)         (60)         (60)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation                                                        2 (3%)                                
      Hypertrophy, Focal                               2 (3%)                                 1 (2%)                                
      Necrosis                                                      1 (2%)                                                          
   Adrenal Gland, Medulla                             (59)         (58)         (59)         (60)                                   
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (34)         (30)         (30)         (25)                                   
      Amyloid Deposition                              12 (35%)     14 (47%)     15 (50%)      8 (32%)                               
      Cyst                                                                       1 (3%)                                             
   Pituitary Gland                                    (54)         (56)         (54)         (56)                                   
      Necrosis                                                                   1 (2%)                                             
      Pars Distalis, Cyst                              3 (6%)                    2 (4%)       3 (5%)                                
      Pars Distalis, Hyperplasia, Focal                1 (2%)       1 (2%)       3 (6%)                                             
   Thyroid Gland                                      (58)         (58)         (56)         (59)                                   
      Amyloid Deposition                              23 (40%)     26 (45%)     22 (39%)     17 (29%)                               
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
      C-Cell, Hyperplasia                                                                     1 (2%)                                
      Follicle, Dilatation                             8 (14%)      7 (12%)      6 (11%)     10 (17%)                               
      Follicular Cell, Hyperplasia                     4 (7%)       8 (14%)      5 (9%)       9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)          (1)                                    
      Granuloma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (60)         (57)         (60)         (59)                                   
      Abscess                                          1 (2%)                                 1 (2%)                                
      Amyloid Deposition                              20 (33%)     21 (37%)     27 (45%)     31 (53%)                               
      Atrophy                                         13 (22%)     14 (25%)     16 (27%)     10 (17%)                               
      Congestion                                                    1 (2%)                                                          
      Cyst                                             6 (10%)     10 (18%)      9 (15%)     13 (22%)                               
      Hematocyst                                                    2 (4%)                    1 (2%)                                
      Hemorrhage                                       2 (3%)       3 (5%)       1 (2%)       3 (5%)                                
      Bilateral, Hemorrhage                            1 (2%)                    1 (2%)                                             
      Follicle, Cyst                                                                          1 (2%)                                
      Periovarian Tissue, Cyst                        13 (22%)      9 (16%)      8 (13%)     12 (20%)                               
   Uterus                                             (60)         (58)         (60)         (59)                                   
      Abscess                                                                    1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Amyloid Deposition                               3 (5%)       2 (3%)       1 (2%)       1 (2%)                                
      Angiectasis, Focal                                                         1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Cervix, Cyst                                     1 (2%)                                                                       
      Cervix, Hypertrophy                              1 (2%)                                 1 (2%)                                
      Cervix, Inflammation, Subacute                                                          1 (2%)                                
      Endometrium, Hyperplasia, Cystic                55 (92%)     57 (98%)     58 (97%)     57 (97%)                               
      Myometrium, Degeneration                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (58)         (60)                                   
      Calvarium, Myelofibrosis                         4 (7%)       2 (3%)                    1 (2%)                                
      Sternal, Myelofibrosis                           4 (7%)       2 (3%)       7 (12%)      2 (3%)                                
   Lymph Node                                         (60)         (60)         (60)         (60)                                   
      Hyperplasia                                                                1 (2%)                                             
      Renal, Hyperplasia                                                                      1 (2%)                                
   Lymph Node, Mandibular                             (57)         (60)         (60)         (60)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Plasma Cell                         1 (2%)                                 1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (57)         (59)         (58)                                   
      Abscess                                          1 (2%)                                                                       
      Amyloid Deposition                               1 (2%)       2 (4%)       3 (5%)       3 (5%)                                
      Granuloma                                                     1 (2%)                    1 (2%)                                
      Hyperplasia                                                   1 (2%)                    3 (5%)                                
      Hyperplasia, Lymphoid                            2 (3%)       1 (2%)                    3 (5%)                                
      Lymphocyte, Necrosis                                                       1 (2%)                                             
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                              25 (42%)     23 (38%)     22 (37%)     19 (32%)                               
      Hematopoietic Cell Proliferation                55 (92%)     52 (87%)     56 (93%)     56 (93%)                               
      Hyperplasia, Lymphoid                            2 (3%)       2 (3%)                    2 (3%)                                
      Pigmentation, Hemosiderin                       22 (37%)     27 (45%)     17 (28%)     24 (40%)                               
      Capsule, Hyperplasia, Focal                                   1 (2%)                                                          
   Thymus                                             (47)         (49)         (42)         (47)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Depletion Lymphoid                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (43)         (44)         (42)                                   
      Hyperplasia                                      3 (8%)       2 (5%)       2 (5%)       1 (2%)                                
      Hyperplastic Alveolar Nodule                     5 (13%)      4 (9%)       1 (2%)       4 (10%)                               
      Inflammation, Chronic                                                      1 (2%)                                             
      Lactation                                        1 (3%)                                                                       
      Duct, Hyperplasia                                             1 (2%)                                                          
   Skin                                               (60)         (60)         (60)         (60)                                   
      Edema                                                                      1 (2%)                                             
      Abdominal, Dermis, Inflammation, Chronic                      3 (5%)       1 (2%)       1 (2%)                                
      Abdominal, Subcutaneous Tissue, Edema           18 (30%)     27 (45%)     17 (28%)     20 (33%)                               
      Face, Acanthosis                                 1 (2%)                                                                       
      Forelimb, Ulcer                                  1 (2%)                                                                       
      Head, Ulcer                                                   1 (2%)                                                          
      Neck, Ulcer                                                   1 (2%)                    1 (2%)                                
      Other, Inflammation, Chronic                     1 (2%)                                                                       
      Tail, Abscess                                                 1 (2%)                                                          
      Thoracic, Acanthosis                             1 (2%)                                                                       
      Thoracic, Ventral, Acanthosis                    1 (2%)                                                                       
      Thoracic, Ventral, Exudate                       1 (2%)                                                                       
   Skin, Control                                      (60)         (60)         (60)         (60)                                   
      Exudate                                          1 (2%)                                                                       
      Hyperkeratosis                                                                          1 (2%)                                
      Dermis, Inflammation, Chronic                    3 (5%)       2 (3%)       3 (5%)                                             
      Subcutaneous Tissue, Edema                       8 (13%)     15 (25%)     12 (20%)      9 (15%)                               
   Skin, Site of Application-No Mass                  (60)         (60)         (60)         (60)                                   
      Acanthosis                                       4 (7%)       1 (2%)                    1 (2%)                                
      Exudate, Focal                                                             1 (2%)                                             
      Hyperkeratosis                                   2 (3%)                                 1 (2%)                                
      Ulcer                                            3 (5%)                                 1 (2%)                                
      Dermis, Inflammation, Chronic                   11 (18%)      9 (15%)      2 (3%)       7 (12%)                               
      Subcutaneous Tissue, Edema                       3 (5%)       9 (15%)      2 (3%)       6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Hemorrhage, Focal                                                          1 (2%)                                             
      Thalamus, Mineralization, Focal                 15 (25%)     17 (28%)      9 (15%)     13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                       2 (3%)       3 (5%)       4 (7%)       2 (3%)                                
      Hemorrhage                                                    2 (3%)                    3 (5%)                                
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Inflammation, Chronic, Focal                    12 (20%)      9 (15%)     14 (23%)      4 (7%)                                
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       1 (2%)                    1 (2%)                                
      Alveolus, Infiltration Cellular, Focal,                                                                                       
          Histiocyte                                   4 (7%)       2 (3%)       2 (3%)       6 (10%)                               
      Artery, Amyloid Deposition                                                 1 (2%)                                             
      Interstitium, Inflammation, Chronic              5 (8%)       5 (8%)       1 (2%)       7 (12%)                               
   Nose                                               (60)         (59)         (60)         (60)                                   
      Exudate                                                                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Glands, Hyperplasia, Focal                                                 1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
      Septum, Amyloid Deposition                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                                                                           
      Bilateral, Ulcer                                 1 (50%)                                                                      
   Eye                                                                          (1)          (1)                                    
      Anterior Chamber, Hemorrhage                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Abscess                                                                                 1 (2%)                                
      Amyloid Deposition                              39 (65%)     45 (75%)     42 (70%)     41 (68%)                               
      Hydronephrosis                                                             1 (2%)       1 (2%)                                
      Hypertrophy                                      1 (2%)                                                                       
      Infarct                                          1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Metaplasia, Osseous                                                        1 (2%)                                             
      Nephropathy                                      5 (8%)       4 (7%)       2 (3%)       5 (8%)                                
      Capsule, Inflammation, Focal                                               1 (2%)                                             
      Cortex, Atrophy                                                            1 (2%)                                             
      Cortex, Atrophy, Focal                           1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Cortex, Cyst                                                  3 (5%)       2 (3%)       1 (2%)                                
      Cortex, Renal Tubule, Mineralization, Focal                                1 (2%)                                             
      Pelvis, Dilatation                               1 (2%)       2 (3%)                    3 (5%)                                
      Proximal Convoluted Renal Tubule,                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE FEMALE                 0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VF           LF           MF            HF                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
          Degeneration, Hyaline                        1 (2%)                                                                       
   Urethra                                                         (1)                                                              
      Bulbourethral Gland, Dilatation                               1 (100%)                                                        
   Urinary Bladder                                    (57)         (54)         (56)         (57)                                   
      Amyloid Deposition                               5 (9%)       1 (2%)       1 (2%)       1 (2%)                                
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Early Deaths                                                                                                                      
    Accidently Killed                                  4            1                         3                                     
    Moribund Sacrifice                                22           34           23           21                                     
    Natural Death                                      5            8           11           12                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                      1                                     
    Terminal Sacrifice                                28           17           26           23                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (57)         (60)         (59)                                   
      Amyloid Deposition                               1 (2%)       1 (2%)                    1 (2%)                                
   Gallbladder                                        (51)         (47)         (50)         (48)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Chronic                            2 (4%)                    1 (2%)                                             
   Intestine Large, Cecum                             (55)         (53)         (50)         (54)                                   
      Amyloid Deposition                                            2 (4%)                    1 (2%)                                
      Edema                                                         1 (2%)                    1 (2%)                                
   Intestine Large, Colon                             (55)         (54)         (53)         (54)                                   
      Amyloid Deposition                                            1 (2%)                    1 (2%)                                
      Edema                                            1 (2%)       7 (13%)      4 (8%)       1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Polyarteritis                                                              1 (2%)       2 (4%)                                
   Intestine Large, Rectum                            (54)         (51)         (51)         (53)                                   
      Amyloid Deposition                                            2 (4%)                    1 (2%)                                
   Intestine Small                                    (60)         (59)         (59)         (59)                                   
      Mucosa, Abscess                                  1 (2%)                                                                       
   Intestine Small, Duodenum                          (57)         (54)         (50)         (49)                                   
      Amyloid Deposition                              27 (47%)     19 (35%)     12 (24%)     12 (24%)                               
      Intussusception                                               1 (2%)                                                          
   Intestine Small, Ileum                             (56)         (55)         (53)         (55)                                   
      Amyloid Deposition                              37 (66%)     40 (73%)     36 (68%)     39 (71%)                               
      Edema                                                                      1 (2%)       1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Intestine Small, Jejunum                           (56)         (51)         (51)         (51)                                   
      Amyloid Deposition                              30 (54%)     32 (63%)     28 (55%)     23 (45%)                               
   Liver                                              (60)         (59)         (60)         (60)                                   
      Amyloid Deposition                              34 (57%)     41 (69%)     31 (52%)     34 (57%)                               
      Degeneration, Fatty                              1 (2%)                                                                       
      Granuloma                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hematopoietic Cell Proliferation                              2 (3%)       2 (3%)       2 (3%)                                
      Inflammation, Chronic, Focal                    18 (30%)     12 (20%)     17 (28%)     17 (28%)                               
      Mitotic Alteration                               1 (2%)                    1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Necrosis, Focal                                  2 (3%)       1 (2%)       1 (2%)       4 (7%)                                
      Pigmentation                                                  1 (2%)                                                          
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
      Centrilobular, Hypertrophy                       2 (3%)       2 (3%)                                                          
   Mesentery                                          (2)          (2)          (1)                                                 
      Granuloma                                        1 (50%)                                                                      
      Polyarteritis                                                 1 (50%)      1 (100%)                                           
      Fat, Necrosis, Focal                                          1 (50%)                                                         
   Pancreas                                           (60)         (58)         (60)         (60)                                   
      Amyloid Deposition, Focal                                     1 (2%)                                                          
      Focal Cellular Change                            2 (3%)       1 (2%)       2 (3%)                                             
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Polyarteritis                                                              1 (2%)       1 (2%)                                
      Acinus, Amyloid Deposition                       1 (2%)       1 (2%)       3 (5%)       1 (2%)                                
      Acinus, Hyperplasia, Focal                                    1 (2%)                                                          
      Acinus, Hypertrophy, Focal                       1 (2%)       2 (3%)                                                          
      Duct, Cyst                                                                 1 (2%)                                             
      Interlobular, Edema                             17 (28%)     23 (40%)     11 (18%)     14 (23%)                               
   Salivary Glands                                    (60)         (58)         (60)         (60)                                   
      Amyloid Deposition                              29 (48%)     39 (67%)     33 (55%)     29 (48%)                               
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Focal, Suppurative                                           1 (2%)       1 (2%)                                
      Interlobular, Edema                             11 (18%)     14 (24%)      9 (15%)     10 (17%)                               
   Stomach                                            (60)         (59)         (60)         (60)                                   
      Pylorus, Amyloid Deposition                                   1 (2%)                                                          
      Submucosa, Edema                                              2 (3%)                    1 (2%)                                
   Stomach, Forestomach                               (59)         (58)         (60)         (60)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                                                          1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (58)         (59)         (60)                                   
      Acanthosis                                       1 (2%)                                                                       
      Amyloid Deposition                               1 (2%)       5 (9%)       4 (7%)       1 (2%)                                
      Submucosa, Inflammation, Acute                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)          (2)          (2)                                    
      Polyarteritis                                                 1 (100%)     1 (50%)                                            
      Aorta, Inflammation, Chronic                                               1 (50%)      1 (50%)                               
      Aorta, Thrombosis                                1 (100%)                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
   Heart                                              (60)         (60)         (59)         (60)                                   
      Amyloid Deposition                              35 (58%)     41 (68%)     34 (58%)     34 (57%)                               
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Necrosis, Focal                                                            2 (3%)       1 (2%)                                
      Polyarteritis                                                              2 (3%)       1 (2%)                                
      Atrium, Thrombosis                              10 (17%)     16 (27%)      9 (15%)      4 (7%)                                
      Pericardium, Inflammation, Focal, Subacute                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (58)         (60)         (60)                                   
      Capsule, Hyperplasia                            44 (73%)     37 (64%)     40 (67%)     39 (65%)                               
      Corticomedullary Junction, Amyloid Deposition   37 (62%)     39 (67%)     32 (53%)     30 (50%)                               
      Corticomedullary Junction, Mineralization,                                                                                    
           Focal                                                                              1 (2%)                                
      Corticomedullary Junction, Pigmentation         33 (55%)     28 (48%)     35 (58%)     35 (58%)                               
      Extra Adrenal Tissue, Hemorrhage                                           1 (2%)                                             
   Adrenal Gland, Cortex                              (60)         (58)         (59)         (59)                                   
      Atrophy                                                                                 1 (2%)                                
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia, Focal                               3 (5%)                    1 (2%)       1 (2%)                                
      Hypertrophy, Focal                                            1 (2%)       2 (3%)       1 (2%)                                
      Hypoplasia                                                    2 (3%)       1 (2%)                                             
      Necrosis                                         1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (24)         (25)         (26)         (30)                                   
      Amyloid Deposition                              12 (50%)     13 (52%)      6 (23%)      8 (27%)                               
   Pituitary Gland                                    (54)         (54)         (50)         (52)                                   
      Pars Distalis, Cyst                              3 (6%)       3 (6%)       3 (6%)       1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                1 (2%)                                                                       
   Thyroid Gland                                      (60)         (56)         (57)         (59)                                   
      Amyloid Deposition                              33 (55%)     30 (54%)     24 (42%)     20 (34%)                               
      Inflammation, Chronic                                         2 (4%)       1 (2%)       1 (2%)                                
      C-Cell, Hyperplasia                              1 (2%)                    1 (2%)       2 (3%)                                
      Follicle, Dilatation                            11 (18%)      7 (13%)     11 (19%)     11 (19%)                               
      Follicular Cell, Hyperplasia                                  2 (4%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (2)          (3)                                                 
      Hemorrhage                                                    1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)                                    (1)                                    
      Dilatation                                       1 (100%)                               1 (100%)                              
   Epididymis                                         (60)         (58)         (60)         (59)                                   
      Edema                                                         1 (2%)       1 (2%)                                             
      Granuloma Sperm                                                            1 (2%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       3 (5%)       2 (3%)       1 (2%)                                
      Necrosis                                         1 (2%)                                                                       
      Fat, Inflammation, Focal, Suppurative                         1 (2%)                                                          
      Fat, Necrosis                                    1 (2%)                                                                       
   Penis                                              (3)          (2)          (4)          (2)                                    
      Inflammation, Acute                                                                     1 (50%)                               
   Preputial Gland                                    (2)                                    (1)                                    
      Abscess                                          1 (50%)                                1 (100%)                              
      Cyst                                             1 (50%)                                                                      
   Prostate                                           (56)         (54)         (54)         (47)                                   
      Hyperplasia, Focal                                            2 (4%)                                                          
      Inflammation, Chronic                            2 (4%)       3 (6%)       1 (2%)                                             
      Inflammation, Suppurative                                                               3 (6%)                                
   Seminal Vesicle                                    (60)         (57)         (60)         (60)                                   
      Abscess                                                                                 1 (2%)                                
      Concretion                                       1 (2%)       1 (2%)                                                          
      Dilatation                                       6 (10%)      6 (11%)      3 (5%)       4 (7%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       5 (9%)                    1 (2%)                                
   Testes                                             (59)         (58)         (59)         (59)                                   
      Cyst                                                                       1 (2%)                                             
      Granuloma Sperm                                               1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                   1 (2%)                                                                       
      Seminiferous Tubule, Atrophy                     3 (5%)       8 (14%)      7 (12%)      9 (15%)                               
      Seminiferous Tubule, Degeneration                3 (5%)       1 (2%)       3 (5%)       1 (2%)                                
      Seminiferous Tubule, Mineralization              1 (2%)       2 (3%)                    1 (2%)                                
      Seminiferous Tubule, Necrosis                    1 (2%)                                                                       
      Tunic, Inflammation, Suppurative                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (58)         (59)         (59)                                   
      Calvarium, Myelofibrosis                         1 (2%)                                                                       
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Mediastinal, Hyperplasia                                                                1 (2%)                                
      Mediastinal, Hyperplasia, Plasma Cell                                                   1 (2%)                                
   Lymph Node, Mandibular                             (56)         (57)         (60)         (60)                                   
      Amyloid Deposition                               1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Plasma Cell                         2 (4%)       2 (4%)       2 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mesenteric                             (57)         (58)         (60)         (58)                                   
      Abscess                                                                    1 (2%)       1 (2%)                                
      Amyloid Deposition                               4 (7%)       5 (9%)       6 (10%)      6 (10%)                               
      Granuloma                                                     1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                 1 (2%)                                
      Hemorrhage                                                                 2 (3%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Plasma Cell                                                                1 (2%)                                
      Polyarteritis                                    1 (2%)                                                                       
   Spleen                                             (60)         (58)         (60)         (60)                                   
      Amyloid Deposition                              30 (50%)     33 (57%)     23 (38%)     28 (47%)                               
      Hematopoietic Cell Proliferation                46 (77%)     49 (84%)     48 (80%)     50 (83%)                               
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
      Pigmentation, Hemosiderin                        8 (13%)      9 (16%)      9 (15%)     11 (18%)                               
   Thymus                                             (46)         (45)         (43)         (40)                                   
      Abscess                                                       1 (2%)                                                          
      Amyloid Deposition                               1 (2%)                                                                       
      Cyst                                                                                    1 (3%)                                
      Depletion Lymphoid                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)                                   
      Acanthosis                                                                              1 (2%)                                
      Edema                                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Exudate, Focal                                                1 (2%)                                                          
      Abdominal, Edema                                 1 (2%)                                                                       
      Abdominal, Inflammation, Chronic                                                        1 (2%)                                
      Abdominal, Dermis, Inflammation, Chronic                      1 (2%)                                                          
      Abdominal, Subcutaneous Tissue, Edema           17 (28%)     24 (40%)     16 (27%)     18 (30%)                               
      Face, Acanthosis                                              1 (2%)                                                          
      Face, Exudate                                                 1 (2%)                                                          
      Face, Ulcer                                                                             1 (2%)                                
      Foot, Ulcer                                                                1 (2%)                                             
      Forelimb, Right, Ulcer                                        1 (2%)                                                          
      Head, Ulcer                                                                             1 (2%)                                
      Head, Ventral, Ulcer                                          1 (2%)                                                          
      Neck, Acanthosis                                              1 (2%)                                                          
      Neck, Fungus                                                  1 (2%)                                                          
      Neck, Inflammation, Subacute                                  1 (2%)                                                          
      Neck, Ulcer                                      1 (2%)       2 (3%)                                                          
      Neck, Subcutaneous Tissue, Hemorrhage                                      1 (2%)                                             
      Other, Inflammation, Chronic                                                            2 (3%)                                
      Other, Ulcer                                                                            2 (3%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Other, Abscess                                                     1 (2%)                                
      Tail, Inflammation, Chronic                                                1 (2%)                                             
   Skin, Control                                      (60)         (60)         (60)         (60)                                   
      Dermis, Inflammation, Chronic                    2 (3%)       1 (2%)                    3 (5%)                                
      Subcutaneous Tissue, Edema                       7 (12%)     17 (28%)      9 (15%)      6 (10%)                               
      Subcutaneous Tissue, Hemorrhage                               1 (2%)                                                          
   Skin, Site of Application-No Mass                  (60)         (60)         (60)         (60)                                   
      Acanthosis                                       1 (2%)       3 (5%)       3 (5%)       1 (2%)                                
      Exudate                                                                    2 (3%)                                             
      Hyperkeratosis                                   1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Ulcer                                                         1 (2%)       3 (5%)                                             
      Dermis, Inflammation, Chronic                                 5 (8%)       4 (7%)       3 (5%)                                
      Subcutaneous Tissue, Edema                       6 (10%)      8 (13%)      5 (8%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (59)         (60)                                   
      Sternum, Hyperostosis                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)         (60)                                   
      Hydrocephalus                                                                           1 (2%)                                
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                1 (2%)                                                          
      Thalamus, Mineralization, Focal                 19 (32%)     11 (19%)     16 (27%)     13 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (58)         (60)         (60)                                   
      Amyloid Deposition, Focal                                     2 (3%)                                                          
      Congestion                                       2 (3%)       5 (9%)       4 (7%)       9 (15%)                               
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       2 (3%)       2 (3%)       1 (2%)       4 (7%)                                
      Inflammation, Chronic, Focal                    13 (22%)      9 (16%)     13 (22%)      8 (13%)                               
      Inflammation, Focal, Subacute                                                           1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Focal          5 (8%)       1 (2%)       2 (3%)       2 (3%)                                
      Alveolus, Infiltration Cellular, Focal,                                                                                       
          Histiocyte                                   6 (10%)      5 (9%)       6 (10%)      6 (10%)                               
      Artery, Amyloid Deposition                       4 (7%)       1 (2%)       1 (2%)                                             
      Interstitium, Inflammation, Chronic              4 (7%)      15 (26%)      6 (10%)     12 (20%)                               
      Vein, Embolus                                                 1 (2%)                                                          
   Nose                                               (60)         (58)         (60)         (60)                                   
      Exudate                                          1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Foreign Body                                     4 (7%)       2 (3%)       1 (2%)       1 (2%)                                
      Fungus                                           1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)                    1 (2%)                                
      Nasolacrimal Duct, Hemorrhage                                              1 (2%)                                             
      Nasolacrimal Duct, Hyperplasia                                             1 (2%)                                             
      Septum, Amyloid Deposition                                                 1 (2%)       1 (2%)                                
      Sinus, Inflammation, Chronic                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (3)          (4)          (4)                                    
      Ulcer                                            1 (100%)     1 (33%)      2 (50%)      3 (75%)                               
      Bilateral, Ulcer                                              2 (67%)      1 (25%)                                            
      External Ear, Acanthosis                                      1 (33%)                                                         
      Pinna, Inflammation, Chronic                                                            1 (25%)                               
   Eye                                                (3)          (2)          (1)          (3)                                    
      Cataract                                         1 (33%)                                1 (33%)                               
      Lids, Inflammation, Chronic                                                             1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Amyloid Deposition                              44 (73%)     44 (73%)     41 (68%)     40 (67%)                               
      Atrophy, Diffuse                                                                        1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Infarct                                                                                 1 (2%)                                
      Inflammation, Chronic, Focal                                                            1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       3 (5%)                                
      Nephropathy                                      7 (12%)      4 (7%)       6 (10%)      5 (8%)                                
      Cortex, Atrophy, Focal                           4 (7%)       3 (5%)       2 (3%)                                             
      Cortex, Cyst                                     6 (10%)      9 (15%)      7 (12%)      7 (12%)                               
      Cortex, Renal Tubule, Mineralization, Focal      4 (7%)       2 (3%)       1 (2%)       1 (2%)                                
      Pelvis, Dilatation                               2 (3%)       4 (7%)       4 (7%)       2 (3%)                                
      Perirenal Tissue, Hemorrhage                                               1 (2%)                                             
   Urethra                                            (2)          (1)          (3)          (2)                                    
      Bulbourethral Gland, Dilatation                  2 (100%)     1 (100%)     2 (67%)      2 (100%)                              
   Urinary Bladder                                    (57)         (55)         (57)         (59)                                   
      Amyloid Deposition                               2 (4%)       1 (2%)       3 (5%)       2 (3%)                                
      Crystals                                                      1 (2%)                    1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Suppurative                                                               2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05098-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 09/13/94  
Route: DERMAL,SOLUTION                                                                                            Time: 11:02:37  
____________________________________________________________________________________________________________________________________
         SWISS WEBSTER MICE MALE                   0MG/KG       40MG/KG      80MG/KG      160MG/KG                                  
                                                   VM           LM           MM            HM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Hyperplasia                                           2 (4%)       1 (2%)       2 (3%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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