TDMS Study 05098-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD P-NITROPHENOL DATE: 09/13/94
EXPERIMENT: 05098 TEST: 01 TIME: 13:11:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES45040 ROUTE: DERMAL,SOLUTION NTP C#: 55992B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 100-02-7
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD P-NITROPHENOL DATE: 09/13/94
EXPERIMENT: 05098 TEST: 01 TIME: 13:11:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES45040 ROUTE: DERMAL,SOLUTION NTP C#: 55992B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 100-02-7
35( )
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD P-NITROPHENOL DATE: 09/13/94
EXPERIMENT: 05098 TEST: 01 TIME: 13:11:31
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES45040 ROUTE: DERMAL,SOLUTION NTP C#: 55992B
PATHOLOGIST: R. CARDY S. EUSTIS CAS: 100-02-7
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF P-NITROPHENOL
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Stomach, Forestomach Squamous Cell Papilloma
Uterus Schwannoma Malignant
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant and Benign Tumors
====================================================================================================
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 7/58 (12%) 6/59 (10%) 6/59 (10%) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 13.2% 37.3% 20.6% 20.5% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/29 (10%) 6/17 (35%) 4/25 (16%) 3/23 (13%) | 0/35 (0%) 0/26 (0%) 0/33 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 536 503 435 442 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.326 P=0.060 P=0.305 P=0.250 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.338 P=0.080 P=0.351 P=0.334 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.299 P=0.115 P=0.332 P=0.272 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.392 | (e) |
|FISHER EXACT | P=0.245 P=0.361 P=0.361 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 5.9% 0.0% 0.0% | 0.0% 3.8% 0.0% 5.6% |
|TERMINAL (d) | 0/29 (0%) 1/17 (6%) 0/26 (0%) 0/24 (0%) | 0/35 (0%) 1/26 (4%) 0/33 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | --- 552 (T) --- --- | --- 552 (T) --- 468 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.573N P=0.393 (e) (e) | P=0.126 P=0.441 (e) P=0.215 |
|INCIDENTAL TUMOR | P=0.573N P=0.393 (e) (e) | P=0.136 P=0.441 (e) P=0.245 |
|LOGISTIC REGRESSION | P=0.573N P=0.393 (e) (e) | P=0.141 P=0.441 (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.567N | P=0.140 |
|FISHER EXACT | P=0.500 (e) (e) | P=0.500 (e) P=0.248 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 7.7% 4.2% | 0.0% 0.0% 0.0% 3.7% |
|TERMINAL (d) | 0/29 (0%) 0/17 (0%) 2/26 (8%) 1/24 (4%) | 0/35 (0%) 0/26 (0%) 0/33 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- 552 (T) 552 (T) | --- --- --- 552 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.239 (e) P=0.214 P=0.462 | P=0.179 (e) (e) P=0.448 |
|INCIDENTAL TUMOR | P=0.239 (e) P=0.214 P=0.462 | P=0.179 (e) (e) P=0.448 |
|LOGISTIC REGRESSION | P=0.239 (e) P=0.214 P=0.462 | P=0.178 (e) (e) P=0.448 |
|COCHRAN-ARMITAGE | P=0.247 | P=0.199 |
|FISHER EXACT | (e) P=0.248 P=0.500 | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/59 (5%) 5/60 (8%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.4% 14.7% 17.9% 4.2% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/29 (3%) 1/17 (6%) 4/26 (15%) 1/24 (4%) | 0/35 (0%) 0/26 (0%) 0/33 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 552 (T) 545 519 552 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.583N P=0.167 P=0.082 P=0.720 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.575 P=0.313 P=0.085 P=0.720 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.569 P=0.192 P=0.092 P=0.720 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.541N | (e) |
|FISHER EXACT | P=0.303 P=0.103 P=0.752N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 11/58 (19%) 12/60 (20%) 6/60 (10%) | 7/60 (12%) 8/60 (13%) 8/60 (13%) 6/60 (10%) |
|ADJUSTED (b) | 11.2% 35.8% 34.0% 20.2% | 16.7% 22.3% 19.9% 18.0% |
|TERMINAL (d) | 2/29 (7%) 3/17 (18%) 6/26 (23%) 4/24 (17%) | 4/35 (11%) 2/26 (8%) 5/33 (15%) 3/27 (11%) |
|FIRST INCIDENCE (DAYS) | 409 438 454 442 | 438 449 446 454 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.409 P=0.014 * P=0.024 * P=0.282 | P=0.476N P=0.360 P=0.479 P=0.609N |
|INCIDENTAL TUMOR | P=0.506 P=0.045 * P=0.025 * P=0.350 | P=0.388N P=0.594N P=0.498 P=0.491N |
|LOGISTIC REGRESSION | P=0.467 P=0.034 * P=0.028 * P=0.341 | P=0.403N P=0.491 P=0.500 P=0.501N |
|COCHRAN-ARMITAGE | P=0.498 | P=0.407N |
|FISHER EXACT | P=0.041 * P=0.029 * P=0.372 | P=0.500 P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 9/58 (16%) 6/60 (10%) 7/60 (12%) | 4/60 (7%) 1/60 (2%) 5/60 (8%) 5/60 (8%) |
|ADJUSTED (b) | 16.6% 35.6% 14.6% 27.6% | 11.4% 2.4% 11.9% 18.5% |
|TERMINAL (d) | 4/29 (14%) 4/17 (24%) 1/26 (4%) 6/24 (25%) | 4/35 (11%) 0/26 (0%) 2/33 (6%) 5/27 (19%) |
|FIRST INCIDENCE (DAYS) | 536 486 293 514 | 552 (T) 497 427 552 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.387 P=0.047 * P=0.469 P=0.247 | P=0.191 P=0.260N P=0.486 P=0.338 |
|INCIDENTAL TUMOR | P=0.477 P=0.091 P=0.495 P=0.292 | P=0.220 P=0.238N P=0.493 P=0.338 |
|LOGISTIC REGRESSION | P=0.417 P=0.099 P=0.499 P=0.231 | P=0.250 P=0.211N P=0.516 P=0.338 |
|COCHRAN-ARMITAGE | P=0.468 | P=0.249 |
|FISHER EXACT | P=0.179 P=0.500 P=0.381 | P=0.182N P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 20/58 (34%) 17/60 (28%) 11/60 (18%) | 11/60 (18%) 9/60 (15%) 12/60 (20%) 11/60 (18%) |
|ADJUSTED (b) | 26.8% 61.4% 42.4% 38.3% | 27.4% 24.1% 28.8% 35.1% |
|TERMINAL (d) | 6/29 (21%) 7/17 (41%) 7/26 (27%) 8/24 (33%) | 8/35 (23%) 2/26 (8%) 7/33 (21%) 8/27 (30%) |
|FIRST INCIDENCE (DAYS) | 409 438 293 442 | 438 449 427 454 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.494 P=0.001 ** P=0.051 P=0.248 | P=0.366 P=0.589N P=0.473 P=0.395 |
|INCIDENTAL TUMOR | P=0.442N P=0.006 ** P=0.053 P=0.333 | P=0.453 P=0.333N P=0.490 P=0.492 |
|LOGISTIC REGRESSION | P=0.505N P=0.005 ** P=0.058 P=0.287 | P=0.475 P=0.426N P=0.517 P=0.576 |
|COCHRAN-ARMITAGE | P=0.455N | P=0.466 |
|FISHER EXACT | P=0.012 * P=0.060 P=0.404 | P=0.404N P=0.500 P=0.593N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 3.1% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 5.7% |
|TERMINAL (d) | 0/29 (0%) 0/17 (0%) 0/26 (0%) 0/24 (0%) | 0/35 (0%) 0/26 (0%) 0/33 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | 532 --- --- --- | --- --- --- 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.325N P=0.566N P=0.506N P=0.549N | P=0.042 * (e) (e) P=0.211 |
|INCIDENTAL TUMOR | P=0.291N P=0.454N P=0.493N P=0.460N | P=0.050 * (e) (e) P=0.245 |
|LOGISTIC REGRESSION | P=0.316N P=0.532N P=0.505N P=0.526N | P=0.046 * (e) (e) P=0.238 |
|COCHRAN-ARMITAGE | P=0.306N | P=0.046 * |
|FISHER EXACT | P=0.500N P=0.500N P=0.500N | (e) (e) P=0.248 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|Tissue NOS |
| Lipoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 3/60 (5%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.4% 0.0% 11.5% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/29 (3%) 0/17 (0%) 3/26 (12%) 0/24 (0%) | 0/35 (0%) 0/26 (0%) 0/33 (0%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 552 (T) --- 552 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.517N P=0.607N P=0.265 P=0.538N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.517N P=0.607N P=0.265 P=0.538N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.517N P=0.607N P=0.265 P=0.538N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.500N | (e) |
|FISHER EXACT | P=0.500N P=0.309 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 4/60 (7%) 2/60 (3%) 6/60 (10%) 1/60 (2%) |
|ADJUSTED (b) | | 10.4% 6.5% 14.3% 3.7% |
|TERMINAL (d) | | 3/35 (9%) 1/26 (4%) 2/33 (6%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | | 463 500 401 552 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.277N P=0.448N P=0.368 P=0.245N |
|INCIDENTAL TUMOR | | P=0.226N P=0.388N P=0.379 P=0.224N |
|LOGISTIC REGRESSION | | P=0.231N P=0.359N P=0.375 P=0.186N |
|COCHRAN-ARMITAGE | | P=0.235N |
|FISHER EXACT | | P=0.340N P=0.372 P=0.182N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/60 (2%) 2/60 (3%) 1/60 (2%) 3/60 (5%) |
|ADJUSTED (b) | | 2.0% 5.9% 3.0% 9.1% |
|TERMINAL (d) | | 0/35 (0%) 1/26 (4%) 1/33 (3%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | | 475 482 552 (T) 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.218 P=0.461 P=0.754 P=0.283 |
|INCIDENTAL TUMOR | | P=0.262 P=0.527 P=0.758N P=0.372 |
|LOGISTIC REGRESSION | | P=0.240 P=0.502 P=0.762 P=0.305 |
|COCHRAN-ARMITAGE | | P=0.238 |
|FISHER EXACT | | P=0.500 P=0.752N P=0.309 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 5/60 (8%) 4/60 (7%) 7/60 (12%) 4/60 (7%) |
|ADJUSTED (b) | | 12.2% 12.2% 17.1% 12.6% |
|TERMINAL (d) | | 3/35 (9%) 2/26 (8%) 3/33 (9%) 2/27 (7%) |
|FIRST INCIDENCE (DAYS) | | 463 482 401 517 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.556N P=0.615N P=0.375 P=0.586N |
|INCIDENTAL TUMOR | | P=0.473N P=0.529N P=0.390 P=0.499N |
|LOGISTIC REGRESSION | | P=0.495N P=0.513N P=0.383 P=0.505N |
|COCHRAN-ARMITAGE | | P=0.500N |
|FISHER EXACT | | P=0.500N P=0.381 P=0.500N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|Uterus |
| Schwannoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | | 0.0% 0.0% 0.0% 5.7% |
|TERMINAL (d) | | 0/35 (0%) 0/26 (0%) 0/33 (0%) 1/27 (4%) |
|FIRST INCIDENCE (DAYS) | | --- --- --- 475 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.042 * (e) (e) P=0.211 |
|INCIDENTAL TUMOR | | P=0.050 * (e) (e) P=0.245 |
|LOGISTIC REGRESSION | | P=0.046 * (e) (e) P=0.238 |
|COCHRAN-ARMITAGE | | P=0.046 * |
|FISHER EXACT | | (e) (e) P=0.248 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 3/60 (5%) 2/60 (3%) | 0/60 (0%) 1/60 (2%) 3/60 (5%) 3/60 (5%) |
|ADJUSTED (b) | 3.4% 0.0% 11.5% 6.6% | 0.0% 1.9% 8.5% 11.1% |
|TERMINAL (d) | 1/29 (3%) 0/17 (0%) 3/26 (12%) 1/24 (4%) | 0/35 (0%) 0/26 (0%) 1/33 (3%) 3/27 (11%) |
|FIRST INCIDENCE (DAYS) | 552 (T) --- 552 (T) 482 | --- 450 545 552 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225 P=0.607N P=0.265 P=0.433 | P=0.052 P=0.500 P=0.121 P=0.079 |
|INCIDENTAL TUMOR | P=0.239 P=0.607N P=0.265 P=0.479 | P=0.046 * P=0.553 P=0.242 P=0.079 |
|LOGISTIC REGRESSION | P=0.206 P=0.607N P=0.265 P=0.461 | P=0.067 P=0.494 P=0.126 P=0.079 |
|COCHRAN-ARMITAGE | P=0.242 | P=0.068 |
|FISHER EXACT | P=0.500N P=0.309 P=0.500 | P=0.500 P=0.122 P=0.122 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 3/60 (5%) 2/60 (3%) | 0/60 (0%) 1/60 (2%) 3/60 (5%) 3/60 (5%) |
|ADJUSTED (b) | 3.4% 0.0% 11.5% 6.6% | 0.0% 1.9% 8.5% 11.1% |
|TERMINAL (d) | 1/29 (3%) 0/17 (0%) 3/26 (12%) 1/24 (4%) | 0/35 (0%) 0/26 (0%) 1/33 (3%) 3/27 (11%) |
|FIRST INCIDENCE (DAYS) | 552 (T) --- 552 (T) 482 | --- 450 545 552 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225 P=0.607N P=0.265 P=0.433 | P=0.052 P=0.500 P=0.121 P=0.079 |
|INCIDENTAL TUMOR | P=0.239 P=0.607N P=0.265 P=0.479 | P=0.046 * P=0.553 P=0.242 P=0.079 |
|LOGISTIC REGRESSION | P=0.206 P=0.607N P=0.265 P=0.461 | P=0.067 P=0.494 P=0.126 P=0.079 |
|COCHRAN-ARMITAGE | P=0.242 | P=0.068 |
|FISHER EXACT | P=0.500N P=0.309 P=0.500 | P=0.500 P=0.122 P=0.122 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 5/60 (8%) 2/60 (3%) | 4/60 (7%) 2/60 (3%) 5/60 (8%) 2/60 (3%) |
|ADJUSTED (b) | 5.3% 10.4% 15.3% 5.1% | 9.4% 4.0% 13.8% 4.0% |
|TERMINAL (d) | 1/29 (3%) 1/17 (6%) 3/26 (12%) 0/24 (0%) | 2/35 (6%) 0/26 (0%) 3/33 (9%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 423 442 362 437 | 373 449 507 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.543 P=0.389 P=0.200 P=0.651 | P=0.408N P=0.391N P=0.487 P=0.379N |
|INCIDENTAL TUMOR | P=0.568N P=0.467 P=0.216 P=0.657N | P=0.346N P=0.302N P=0.639 P=0.278N |
|LOGISTIC REGRESSION | P=0.579N P=0.501 P=0.219 P=0.686N | P=0.371N P=0.333N P=0.505 P=0.338N |
|COCHRAN-ARMITAGE | P=0.579 | P=0.368N |
|FISHER EXACT | P=0.500 P=0.219 P=0.691N | P=0.340N P=0.500 P=0.340N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 5/60 (8%) 2/60 (3%) | 4/60 (7%) 2/60 (3%) 5/60 (8%) 2/60 (3%) |
|ADJUSTED (b) | 5.3% 10.4% 15.3% 5.1% | 9.4% 4.0% 13.8% 4.0% |
|TERMINAL (d) | 1/29 (3%) 1/17 (6%) 3/26 (12%) 0/24 (0%) | 2/35 (6%) 0/26 (0%) 3/33 (9%) 0/27 (0%) |
|FIRST INCIDENCE (DAYS) | 423 442 362 437 | 373 449 507 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.543 P=0.389 P=0.200 P=0.651 | P=0.408N P=0.391N P=0.487 P=0.379N |
|INCIDENTAL TUMOR | P=0.568N P=0.467 P=0.216 P=0.657N | P=0.346N P=0.302N P=0.639 P=0.278N |
|LOGISTIC REGRESSION | P=0.579N P=0.501 P=0.219 P=0.686N | P=0.371N P=0.333N P=0.505 P=0.338N |
|COCHRAN-ARMITAGE | P=0.579 | P=0.368N |
|FISHER EXACT | P=0.500 P=0.219 P=0.691N | P=0.340N P=0.500 P=0.340N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 13/60 (22%) 23/60 (38%) 22/60 (37%) 12/60 (20%) | 15/60 (25%) 10/60 (17%) 15/60 (25%) 14/60 (23%) |
|ADJUSTED (b) | 38.4% 76.6% 60.6% 38.3% | 34.1% 28.8% 34.8% 37.5% |
|TERMINAL (d) | 9/29 (31%) 11/17 (65%) 13/26 (50%) 7/24 (29%) | 9/35 (26%) 4/26 (15%) 8/33 (24%) 7/27 (26%) |
|FIRST INCIDENCE (DAYS) | 409 438 435 442 | 370 449 401 411 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.386N P<0.001 ** P=0.033 * P=0.474 | P=0.380 P=0.372N P=0.554 P=0.489 |
|INCIDENTAL TUMOR | P=0.297N P=0.007 ** P=0.038 * P=0.556N | P=0.502 P=0.148N P=0.580N P=0.495N |
|LOGISTIC REGRESSION | P=0.355N P=0.007 ** P=0.040 * P=0.548 | P=0.484 P=0.194N P=0.579 P=0.500N |
|COCHRAN-ARMITAGE | P=0.266N | P=0.479 |
|FISHER EXACT | P=0.036 * P=0.054 P=0.500N | P=0.184N P=0.583N P=0.500N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 40MG/KG 80MG/KG 160MG/KG | 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| | VM LM MM HM | VF LF MF HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 13/60 (22%) 14/60 (23%) 13/60 (22%) | 13/60 (22%) 8/60 (13%) 16/60 (27%) 17/60 (28%) |
|ADJUSTED (b) | 28.0% 44.6% 36.9% 41.6% | 30.9% 18.2% 36.0% 46.6% |
|TERMINAL (d) | 7/29 (24%) 5/17 (29%) 6/26 (23%) 8/24 (33%) | 8/35 (23%) 1/26 (4%) 7/33 (21%) 10/27 (37%) |
|FIRST INCIDENCE (DAYS) | 423 442 293 427 | 373 375 427 463 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.190 P=0.051 P=0.148 P=0.124 | P=0.070 P=0.300N P=0.331 P=0.140 |
|INCIDENTAL TUMOR | P=0.264 P=0.112 P=0.161 P=0.184 | P=0.114 P=0.150N P=0.423 P=0.237 |
|LOGISTIC REGRESSION | P=0.218 P=0.156 P=0.172 P=0.159 | P=0.097 P=0.166N P=0.349 P=0.259 |
|COCHRAN-ARMITAGE | P=0.249 | P=0.096 |
|FISHER EXACT | P=0.240 P=0.177 P=0.240 | P=0.168N P=0.335 P=0.264 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 20/60 (33%) 33/60 (55%) 33/60 (55%) 21/60 (35%) | 25/60 (42%) 16/60 (27%) 28/60 (47%) 26/60 (43%) |
|ADJUSTED (b) | 57.7% 87.7% 79.1% 58.7% | 52.0% 39.9% 56.8% 63.9% |
|TERMINAL (d) | 15/29 (52%) 13/17 (76%) 18/26 (69%) 11/24 (46%) | 14/35 (40%) 5/26 (19%) 13/33 (39%) 14/27 (52%) |
|FIRST INCIDENCE (DAYS) | 409 438 293 427 | 120 375 401 411 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.503 P<0.001 ** P=0.008 ** P=0.250 | P=0.152 P=0.228N P=0.356 P=0.273 |
|INCIDENTAL TUMOR | P=0.407N P=0.001 ** P=0.007 ** P=0.424 | P=0.245 P=0.039N* P=0.418 P=0.475 |
|LOGISTIC REGRESSION | P=0.479N P=0.002 ** P=0.009 ** P=0.350 | P=0.218 P=0.058N P=0.317 P=0.500 |
|COCHRAN-ARMITAGE | P=0.388N | P=0.217 |
|FISHER EXACT | P=0.013 * P=0.013 * P=0.500 | P=0.062N P=0.357 P=0.500 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05098 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN 35( ) -- P-NITROPHENOL
TERMINAL SACRIFICE AT 79 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).