TDMS Study 05098-01 Pathology Tables
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
Facility: Hazleton, Maryland
Chemical CAS #: 100-02-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|
| 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M A + A + + + + + + + + M + + + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + A + + + + + + + A + + + + + + + + +|
Polyarteritis | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + A + + + + + + + A + + + + + + + + +|
Amyloid Deposition | 4 |
Edema | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + M + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 2 3 2 2 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + A + + + + + + + + +|
Amyloid Deposition | 3 3 4 3 4 4 3 4 3 3 3 3 3 3|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + M + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 2 3 2 3 2 2 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 2 2 2 2 2 2|
Angiectasis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 2 2 1 1 2 3 1 2 2 1 2 |
Necrosis, Focal | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Acinus, Amyloid Deposition | 3 3 |
Acinus, Hypertrophy, Focal | |
Interlobular, Edema | 3 2 2 2 3 2 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 3 3 4 3 3 3|
Inflammation, Chronic | 2 |
Interlobular, Edema | 3 2 2 2 2 3 2 4 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 |
Necrosis | 2 |
Epithelium, Vacuolization Cytoplasmic| 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 2 2 3 2 2 3 2 3 4 3 2 3|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|
| 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 2 3 2 2 3 2 2 3 2 2 3 2 3 2 3 2 2 2 2 2 2 2|
Corticomedullary Junction, Amyloid | |
Deposition | 4 2 3 4 2 4 1 2 3 3 4 2 2 4|
Corticomedullary Junction, Hemorrhage| 2 3 |
Corticomedullary Junction, | |
Pigmentation | 2 3 3 4 3 3 4 3 1 2 4 3 3 2 3|
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 4 2 4 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hypertrophy, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + M I M + + + + M + + M + M + + + M|
Amyloid Deposition | 2 3 3 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + M + + + + + M + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 4 3 2 2 3 3 4 3 3 3|
Inflammation, Chronic | 2 |
Follicle, Dilatation | 2 2 3 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Amyloid Deposition | 4 2 4 4 4 4 3 4 4 |
Atrophy | 3 3 3 2 3 |
Cyst | X X |
Hemorrhage | 3 |
Bilateral, Hemorrhage | 4 |
Periovarian Tissue, Cyst | X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 |
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|
| 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 1 |
Cervix, Cyst | |
Cervix, Hypertrophy | 3 |
Endometrium, Hyperplasia, Cystic | 3 4 3 3 3 3 4 4 2 2 3 3 4 4 3 4 4 3 4 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + M + + + + + + + +|
Calvarium, Myelofibrosis | |
Sternal, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 2 2 4 4 2 2 1|
Hematopoietic Cell Proliferation | 2 2 2 2 3 3 2 4 2 3 2 2 2 2 3 3 2 2 1 2 2 2 2|
Hyperplasia, Lymphoid | 4 |
Pigmentation, Hemosiderin | 2 3 2 2 2 2 2 2 3 2 3 3|
__________________________________________________________________________|
Thymus | + + + + + + + I M + M M + M + + + + + + M + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + M M + + + + M + M + + + + M + M + +|
Hyperplasia | 3 3 3 |
Hyperplastic Alveolar Nodule | X X X |
Lactation | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Subcutaneous Tissue, Edema| 2 2 2 4 3 3 2 |
Face, Acanthosis | |
Forelimb, Ulcer | |
Other, Inflammation, Chronic | |
Thoracic, Acanthosis | |
Thoracic, Ventral, Acanthosis | |
Thoracic, Ventral, Exudate | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | 3 2 3 1 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|
| 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 2 |
Dermis, Inflammation, Chronic | 2 2 2 2 2|
Subcutaneous Tissue, Edema | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
Inflammation, Chronic, Focal | 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 3 3|
Interstitium, Inflammation, Chronic | 1 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Bilateral, Ulcer | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 3 4 3 4 4 4 4 3 4 3 4 4 4|
Hypertrophy | 3 |
Infarct | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
Inflammation, Suppurative | 4 |
Nephropathy | 2 1 3 |
Cortex, Atrophy, Focal | |
Pelvis, Dilatation | |
Proximal Convoluted Renal Tubule, | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|
| 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2|
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|
DAY ON TEST | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|
| 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Edema | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 2 2 1 2 2 1 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 3 2 3 4 4 4 3 2 3 4 3 3 3 3 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + A + + + + + +|
Amyloid Deposition | 3 3 2 3 3 4 2 2 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 2 2 2 2 2 2 2 1 2 2 3 3 |
Angiectasis, Focal | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 3|
Inflammation, Chronic, Focal | 2 1 2 2 2 2 2 2 2|
Necrosis, Focal | |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X |
Acinus, Amyloid Deposition | |
Acinus, Hypertrophy, Focal | 2 2 |
Interlobular, Edema | 3 3 2 3 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 2 3 3 2 2 1 2 3 4 2 2 |
Inflammation, Chronic | |
Interlobular, Edema | 3 4 2 3 3 3 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 |
Necrosis | |
Epithelium, Vacuolization Cytoplasmic| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 4 2 2 1 2 2 3 4 2 2 3 2 4 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|
DAY ON TEST | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|
| 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 3 4 2 3 3 3 3 2 2 2 3 2 2 2 2 2 3 2 3 2 2 2 3|
Corticomedullary Junction, Amyloid | |
Deposition | 4 4 3 2 2 2 1 4 2 2 3 4 4 3 2 2 2 |
Corticomedullary Junction, Hemorrhage| |
Corticomedullary Junction, | |
Pigmentation | 2 4 3 4 2 3 3 2 2 2 2 3 4 2 3 3|
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + A + + M + M + M + M M + + M M M M + + M + M + M|
Amyloid Deposition | 2 3 2 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Amyloid Deposition | 1 3 2 3 3 2 3 2 1 2 |
Inflammation, Chronic | |
Follicle, Dilatation | 2 2 |
Follicular Cell, Hyperplasia | 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 3 4 4 3 4 3 3 2 |
Atrophy | 2 2 2 2 3 |
Cyst | X X X |
Hemorrhage | 3 |
Bilateral, Hemorrhage | |
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Congestion | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|
DAY ON TEST | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|
| 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Cervix, Cyst | |
Cervix, Hypertrophy | |
Endometrium, Hyperplasia, Cystic | 4 3 4 3 3 3 3 4 4 4 4 4 4 3 3 3 3 3 4 3 4 4 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 3 3 2 2 |
Sternal, Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Amyloid Deposition | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 2 2 2 2 4 2 1 2 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 1 2 3 2 2 2 2 3 1 2 2 2 2 3 2 2 2|
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + I + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + + + + + + M M + M M M + M M + M + + M|
Hyperplasia | |
Hyperplastic Alveolar Nodule | X |
Lactation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Subcutaneous Tissue, Edema| 4 3 3 3 2 3 |
Face, Acanthosis | 2 |
Forelimb, Ulcer | 4 |
Other, Inflammation, Chronic | |
Thoracic, Acanthosis | 2 |
Thoracic, Ventral, Acanthosis | 3 |
Thoracic, Ventral, Exudate | 3 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | 2 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 1 |
Hyperkeratosis | 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|
DAY ON TEST | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|
| 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Ulcer | 2 3 |
Dermis, Inflammation, Chronic | 2 2 2 2 1 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic, Focal | 2 1 2 2 3 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | |
Interstitium, Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Bilateral, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 4 4 4 4 1 4 3 3 3 4 3 4 3 4 2 3 |
Hypertrophy | |
Infarct | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Suppurative | |
Nephropathy | 1 |
Cortex, Atrophy, Focal | 4 |
Pelvis, Dilatation | |
Proximal Convoluted Renal Tubule, | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|
DAY ON TEST | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|
| 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + I + + + + +|
Amyloid Deposition | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| | |
DAY ON TEST | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1| | |
| 3| 2| 4| 5| 3| 3| 3| 3| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
Amyloid Deposition | | 1 4.0|
Edema | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Amyloid Deposition | 2 1 2 1 | 24 1.9|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
Amyloid Deposition | 4 3 3 3 4 2 | 37 3.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 55 |
Amyloid Deposition | 2 1 2 1 2 | 25 2.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 2 2 1 | 30 2.1|
Angiectasis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hyperplasia, Focal | | 1 3.0|
Inflammation, Chronic, Focal | 2 1 2 2 | 24 1.8|
Necrosis, Focal | | 1 2.0|
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Focal Cellular Change | | 2 |
Acinus, Amyloid Deposition | | 2 3.0|
Acinus, Hypertrophy, Focal | | 2 2.0|
Interlobular, Edema | 3 | 15 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 2 2 2 | 27 2.6|
Inflammation, Chronic | | 1 2.0|
Interlobular, Edema | 3 2 | 18 2.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Amyloid Deposition | | 5 2.2|
Necrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| | |
DAY ON TEST | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1| | |
| 3| 2| 4| 5| 3| 3| 3| 3| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Vacuolization Cytoplasmic| | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 3 3 4 2 | 37 2.5|
Atrium, Thrombosis | X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
Capsule, Hyperplasia | 3 3 2 2 2 3 3 2 2 | 56 2.4|
Corticomedullary Junction, Amyloid | | |
Deposition | 3 2 2 1 2 2 | 37 2.6|
Corticomedullary Junction, Hemorrhage| | 2 2.5|
Corticomedullary Junction, | | |
Pigmentation | 3 4 3 2 2 2 | 37 2.8|
Corticomedullary Junction, | | |
Vacuolization Cytoplasmic | 4 | 6 3.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 4.0|
Hypertrophy, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + M M | 34 |
Amyloid Deposition | 2 2 | 12 2.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + M | 54 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M | 58 |
Amyloid Deposition | 3 | 23 2.6|
Inflammation, Chronic | | 1 2.0|
Follicle, Dilatation | 2 | 8 2.0|
Follicular Cell, Hyperplasia | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| | |
DAY ON TEST | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1| | |
| 3| 2| 4| 5| 3| 3| 3| 3| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Abscess | | 1 3.0|
Amyloid Deposition | 3 2 2 | 20 3.3|
Atrophy | 3 3 2 | 13 2.5|
Cyst | X | 6 |
Hemorrhage | | 2 3.0|
Bilateral, Hemorrhage | | 1 4.0|
Periovarian Tissue, Cyst | X X X X | 13 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Amyloid Deposition | | 3 2.7|
Congestion | | 1 2.0|
Hyperplasia | | 1 1.0|
Cervix, Cyst | X | 1 |
Cervix, Hypertrophy | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 3 4 3 3 4 3 4 4 4 | 55 3.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Calvarium, Myelofibrosis | | 4 2.5|
Sternal, Myelofibrosis | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Amyloid Deposition | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 1 2 2 | 25 2.2|
Hematopoietic Cell Proliferation | 3 2 2 2 2 3 2 3 | 55 2.2|
Hyperplasia, Lymphoid | | 2 3.0|
Pigmentation, Hemosiderin | 2 2 2 | 22 2.1|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + M | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + M + M | 38 |
Hyperplasia | | 3 3.0|
Hyperplastic Alveolar Nodule | X | 5 |
Lactation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| | |
DAY ON TEST | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1| | |
| 3| 2| 4| 5| 3| 3| 3| 3| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abdominal, Subcutaneous Tissue, Edema| 3 2 3 2 3 | 19 2.8|
Face, Acanthosis | | 1 2.0|
Forelimb, Ulcer | | 1 4.0|
Other, Inflammation, Chronic | 2 | 1 2.0|
Thoracic, Acanthosis | | 1 2.0|
Thoracic, Ventral, Acanthosis | | 1 3.0|
Thoracic, Ventral, Exudate | | 1 3.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Exudate | | 1 2.0|
Dermis, Inflammation, Chronic | 1 | 3 1.7|
Subcutaneous Tissue, Edema | 3 | 8 2.3|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | | 4 1.8|
Hyperkeratosis | | 2 2.0|
Ulcer | | 3 2.3|
Dermis, Inflammation, Chronic | 2 | 11 1.9|
Subcutaneous Tissue, Edema | | 3 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization, Focal | 1 1 1 | 15 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
Inflammation, Chronic, Focal | 2 2 2 | 12 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 3 | 4 3.0|
Interstitium, Inflammation, Chronic | | 5 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| | |
DAY ON TEST | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1| | |
| 3| 2| 4| 5| 3| 3| 3| 3| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Bilateral, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | 4 4 3 3 4 3 | 39 3.5|
Hypertrophy | | 1 3.0|
Infarct | | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Nephropathy | 1 | 5 1.6|
Cortex, Atrophy, Focal | | 1 4.0|
Pelvis, Dilatation | 3 | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Amyloid Deposition | 3 | 5 2.6|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|
DAY ON TEST | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|
| 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 |
__________________________________________________________________________|
Gallbladder | + + M + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 3 2 2 2 2 4 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 3 4 4 3 3 2 4 4 1 3 4 2 3 3 4 4 3 3 4|
Mucosa, Inflammation, Focal | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 3 2 3 2 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 2 2 2 2 2 2 3 1 3 2 2 2 2 |
Angiectasis, Focal | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic, Focal | 1 1 1 3 2 2 1 2 2 1 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Necrosis, Focal | |
Acinus, Amyloid Deposition | 2 |
Acinus, Hypertrophy, Focal | |
Interlobular, Edema | 3 3 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 3 2 2 3 2 3 3 2 3 4 3 |
Interlobular, Edema | 3 3 2 4 2 3 3 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 3 2 2 2 2 2 3 1 3 3 3 2 4 |
Fibrosis | 2 |
Inflammation, Acute | 3 |
Necrosis, Focal | 3 |
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|
DAY ON TEST | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|
| 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 2 3 3 2 3 3 3 2 2 3 2 3 2 3 3 2 2 3 2 2 3 3 2 2|
Corticomedullary Junction, Amyloid | |
Deposition | 4 4 2 3 3 2 3 2 2 4 2 4 3 4 4 2 3 |
Corticomedullary Junction, Hemorrhage| 2 |
Corticomedullary Junction, | |
Pigmentation | 2 3 3 4 3 2 3 2 2 2 3 3 |
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 2 3 2 2 2 4|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M + + I + + M + M M + M + + M M M + M + M +|
Amyloid Deposition | 3 3 2 2 3 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + I + + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 3 3 2 1 3 2 1 4 3 2 |
Inflammation, Chronic | |
Follicle, Dilatation | 2 2 2 |
Follicular Cell, Hyperplasia | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Amyloid Deposition | 4 2 4 4 3 2 4 3 4 |
Atrophy | 3 3 3 4 3 |
Congestion | 3 |
Cyst | X X X X X X |
Hematocyst | X |
Hemorrhage | 2 4 2 |
Periovarian Tissue, Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Amyloid Deposition | 2 |
Endometrium, Hyperplasia, Cystic | 4 2 2 4 3 3 3 4 3 3 3 4 4 4 3 3 3 3 3 2 3 3 3|
Myometrium, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | |
Sternal, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|
DAY ON TEST | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|
| 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + I + + + + + + + + + + + + + + + + M + + + + + +|
Amyloid Deposition | 2 |
Granuloma | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 1 2 2 3 3 4 2 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 2 3 2 2 2 3 2 2 2 2 1 2 1 2 2 2|
Hyperplasia, Lymphoid | 3 3 |
Pigmentation, Hemosiderin | 2 1 2 2 2 2 2 2 2 2 3 1 2 |
Capsule, Hyperplasia, Focal | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + + M + + M + M + + + + + + + + + + + + M|
Hyperplasia | |
Hyperplastic Alveolar Nodule | X X |
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Dermis, Inflammation, | |
Chronic | 2 2 |
Abdominal, Subcutaneous Tissue, Edema| 2 4 3 3 2 3 4 3 4 2 3 3 |
Head, Ulcer | |
Neck, Ulcer | |
Tail, Abscess | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 3 2 3 3 2 2 3 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Dermis, Inflammation, Chronic | 2 2 2 2 |
Subcutaneous Tissue, Edema | 3 3 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 2 1 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|
DAY ON TEST | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|
| 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 |
Hemorrhage | |
Inflammation, Chronic, Focal | 2 4 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 |
Interstitium, Inflammation, Chronic | 2 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 4 4 3 3 4 4 4 2 4 4 3 4 4 4 4 4 3 |
Infarct | |
Nephropathy | 1 1 |
Cortex, Atrophy, Focal | 3 |
Cortex, Cyst | X |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|
| 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + A + A + + +|
Amyloid Deposition | 2 1 3 2 2 2 2 2 2 3 3|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + A + A + + +|
Amyloid Deposition | 3 3 3 3 4 4 2 2 2 4 3 4 3 3 3 4|
Mucosa, Inflammation, Focal | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + A + A + + +|
Amyloid Deposition | 2 2 3 4 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 3 4 2 2 2 2 2 2 2 2 1 2|
Angiectasis, Focal | |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic, Focal | 2 2 3 3 2 2 2 1 2 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + A + + +|
Focal Cellular Change | |
Necrosis, Focal | 2|
Acinus, Amyloid Deposition | |
Acinus, Hypertrophy, Focal | 2 |
Interlobular, Edema | 3 3 2 3 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 4 3 2 3 2 2 3 3 1 3|
Interlobular, Edema | 2 3 2 3 3 4 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2 2 3 2 3 3 3 2 2 2 2 2|
Fibrosis | |
Inflammation, Acute | |
Necrosis, Focal | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|
| 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 3 3 3 3 3 2 2 3 3 2 2 2 3 3 2 3 3 2 3 2 2|
Corticomedullary Junction, Amyloid | |
Deposition | 3 3 2 2 4 3 3 3 3 3 3 3 3 2 1 3 3 3|
Corticomedullary Junction, Hemorrhage| |
Corticomedullary Junction, | |
Pigmentation | 2 2 2 2 2 4 3 3 4 2 3 2 2 2 4 |
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 2 4 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M M M + M M M + A + + + M M + + M M M M|
Amyloid Deposition | 2 3 3 4 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 3 3 4 3 3 3 4 2 2|
Inflammation, Chronic | 3 |
Follicle, Dilatation | 2 2 2 |
Follicular Cell, Hyperplasia | 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | 4 2 3 3 3 4 3 4 4|
Atrophy | 2 2 3 2 2 2 3 2 2 |
Congestion | |
Cyst | X X X |
Hematocyst | |
Hemorrhage | |
Periovarian Tissue, Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 4 3 3 3 4 3 3 3 4 4 3 4 3 3 3 3 4 4 3 4 3 2|
Myometrium, Degeneration | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 2 2 |
Sternal, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|
| 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | |
Granuloma | 4 |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 3 2 3 3 2 2 2 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 3 3 2 2 2 2 2 2 3 4 2 2 2 2|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 1 3 2 2 2 2 2 2 3|
Capsule, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + M M + + + I + + + + M + + + +|
Depletion Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + + + M + + + + M M + + + + + + + M + + +|
Hyperplasia | 2 |
Hyperplastic Alveolar Nodule | X |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Dermis, Inflammation, | |
Chronic | 2 |
Abdominal, Subcutaneous Tissue, Edema| 2 3 3 3 4 4 3 3 3 3 |
Head, Ulcer | 4 |
Neck, Ulcer | 4 |
Tail, Abscess | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 2 2 |
Subcutaneous Tissue, Edema | 3 3 3 3 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Dermis, Inflammation, Chronic | 2 1 2 2 |
Subcutaneous Tissue, Edema | 2 2 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|
| 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 |
Hemorrhage | 2 3 |
Inflammation, Chronic, Focal | 2 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 1 |
Interstitium, Inflammation, Chronic | 2 2|
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + I + + + + + + + + + A + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 1 3 4 4 4 4 4 1 4 4 4 4 4 1 2 3 3 3 3|
Infarct | |
Nephropathy | 2 |
Cortex, Atrophy, Focal | |
Cortex, Cyst | X |
Pelvis, Dilatation | 3 3 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + M A + + + + + + + + + + + + + + + + + A + M +|
Amyloid Deposition | 3 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 2| 5| 5| 5| 4| 5| | |
DAY ON TEST | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5| | |
| 5| 2| 0| 7| 6| 2| 0| 5| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + + | 59 |
Amyloid Deposition | | 2 1.5|
__________________________________________________________________________|____________|
Gallbladder | + + A M + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
Amyloid Deposition | 4 2 2 | 23 2.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
Amyloid Deposition | 3 3 3 3 3 3 3 | 45 3.2|
Mucosa, Inflammation, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M + + + + M + | 54 |
Amyloid Deposition | 1 3 2 2 | 30 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 2 2 2 | 37 2.1|
Angiectasis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Inflammation, Chronic, Focal | 2 1 | 21 1.8|
Necrosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 57 |
Focal Cellular Change | | 1 |
Necrosis, Focal | | 1 2.0|
Acinus, Amyloid Deposition | | 1 2.0|
Acinus, Hypertrophy, Focal | | 1 2.0|
Interlobular, Edema | 3 3 3 | 15 2.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 3 2 | 29 2.8|
Interlobular, Edema | 3 3 3 3 | 21 2.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 1 2 | 35 2.3|
Fibrosis | | 1 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 2| 5| 5| 5| 4| 5| | |
DAY ON TEST | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5| | |
| 5| 2| 0| 7| 6| 2| 0| 5| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Necrosis, Focal | | 1 3.0|
Atrium, Thrombosis | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
Capsule, Hyperplasia | 2 2 2 2 3 2 2 2 2 | 54 2.5|
Corticomedullary Junction, Amyloid | | |
Deposition | 3 2 2 2 2 | 40 2.8|
Corticomedullary Junction, Hemorrhage| | 1 2.0|
Corticomedullary Junction, | | |
Pigmentation | 2 2 2 3 2 2 2 | 34 2.5|
Corticomedullary Junction, | | |
Vacuolization Cytoplasmic | 3 | 9 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + M + | 30 |
Amyloid Deposition | 2 2 | 14 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + | 56 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + | 58 |
Amyloid Deposition | 2 2 | 26 2.5|
Inflammation, Chronic | 2 | 2 2.5|
Follicle, Dilatation | 2 | 7 2.0|
Follicular Cell, Hyperplasia | 1 | 8 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + M + + + + + + | 57 |
Amyloid Deposition | 4 4 2 | 21 3.3|
Atrophy | | 14 2.6|
Congestion | | 1 3.0|
Cyst | X | 10 |
Hematocyst | X | 2 |
Hemorrhage | | 3 2.7|
Periovarian Tissue, Cyst | X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 2| 5| 5| 5| 4| 5| | |
DAY ON TEST | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5| | |
| 5| 2| 0| 7| 6| 2| 0| 5| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 58 |
Amyloid Deposition | | 2 2.5|
Endometrium, Hyperplasia, Cystic | 3 3 2 3 4 4 3 3 3 3 | 57 3.2|
Myometrium, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Calvarium, Myelofibrosis | | 2 2.0|
Sternal, Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Amyloid Deposition | 2 | 2 2.0|
Granuloma | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 2 | 23 2.3|
Hematopoietic Cell Proliferation | 3 1 2 2 2 2 2 2 2 2 | 52 2.1|
Hyperplasia, Lymphoid | | 2 3.0|
Pigmentation, Hemosiderin | 2 3 2 | 27 2.0|
Capsule, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + M M + + + | 49 |
Depletion Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M + M + + + + | 43 |
Hyperplasia | 1 | 2 1.5|
Hyperplastic Alveolar Nodule | X | 4 |
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abdominal, Dermis, Inflammation, | | |
Chronic | | 3 2.0|
Abdominal, Subcutaneous Tissue, Edema| 3 3 3 3 2 | 27 3.0|
Head, Ulcer | | 1 4.0|
Neck, Ulcer | | 1 4.0|
Tail, Abscess | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Dermis, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 2| 5| 5| 5| 4| 5| | |
DAY ON TEST | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5| | |
| 5| 2| 0| 7| 6| 2| 0| 5| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Edema | 2 2 3 | 15 2.6|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | | 1 1.0|
Dermis, Inflammation, Chronic | 2 | 9 1.9|
Subcutaneous Tissue, Edema | 3 | 9 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization, Focal | 1 1 2 1 1 | 17 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 | 3 2.3|
Hemorrhage | | 2 2.5|
Inflammation, Chronic, Focal | 2 | 9 2.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | | 2 2.0|
Interstitium, Inflammation, Chronic | | 5 2.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + M M + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 4 4 4 4 | 45 3.5|
Infarct | 4 | 1 4.0|
Nephropathy | 1 | 4 1.3|
Cortex, Atrophy, Focal | | 1 3.0|
Cortex, Cyst | X | 3 |
Pelvis, Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 2| 5| 5| 5| 4| 5| | |
DAY ON TEST | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5| | |
| 5| 2| 0| 7| 6| 2| 0| 5| 0| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Bulbourethral Gland, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + | 54 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|
| 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + M + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + M +|
Amyloid Deposition | |
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + A + + + + + + + M + + M +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + M + + M +|
Amyloid Deposition | 1 2 2 2 1 2 2 1 2|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 3 3 3 2 3 3 4 4 3 4 3 3 4 3 3 4 3 3 3|
Edema | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + M + + + +|
Amyloid Deposition | 1 2 3 2 2 2 1 2 2 3 1 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 4 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Inflammation, Chronic, Focal | 1 2 2 2 1 2 1 2 2 |
Necrosis, Focal | 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Polyarteritis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1|
Focal Cellular Change | |
Acinus, Amyloid Deposition | 4 |
Acinus, Hypertrophy, Focal | 2 |
Interlobular, Edema | 2 2 3 2 2 2 3 3|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 3 2 2 2 2 3 3 3 3 3 3 3 3 2 |
Inflammation, Focal, Suppurative | 3 |
Interlobular, Edema | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Mucosa, Degeneration | 3 |
Mucosa, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|
| 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 2 3 2 2 1 2 2 2 3 2 2 2 2 2 2|
Polyarteritis | 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 3 2 2 2 2 2 2 2 3 2 2 3 2 1 3 3 3 3 2 2 2|
Corticomedullary Junction, Amyloid | |
Deposition | 4 3 2 3 3 2 3 3 2 3 2 3 4 3 |
Corticomedullary Junction, | |
Pigmentation | 3 2 2 3 2 3 2 1 2 2 2 3 3 2 3 2|
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + M +|
__________________________________________________________________________|
Parathyroid Gland | + + M M M M + M M + + + A M + + + M M M M M + M +|
Amyloid Deposition | 2 2 2 2 1 2 2 2|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + M + + + + + M + + + +|
Necrosis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + A + + + +|
Amyloid Deposition | 2 2 2 2 2 3 2 2 2 3 1 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Follicle, Dilatation | 2 |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 3 2 4 3 4 3 4 4 2 4 4 2|
Atrophy | 3 3 2 3 3 3 |
Cyst | X X X X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|
| 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Hemorrhage | |
Periovarian Tissue, Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Amyloid Deposition | 3 |
Angiectasis, Focal | |
Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 3 4 4 3 3 4 4 3 4 3 3 4 1 3 3 3 3 3 4 4 3 4 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + M A + + + +|
Sternal, Myelofibrosis | 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | 2 2 1 |
Lymphocyte, Necrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 2 1 2 1 3 2 4 4 2|
Hematopoietic Cell Proliferation | 2 2 2 2 1 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 1 2 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + M I + + M M M I + I M|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M + M + + M M + + + + + + + + M M + + + +|
Hyperplasia | 1 1 |
Hyperplastic Alveolar Nodule | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Abdominal, Dermis, Inflammation, | |
Chronic | 2 |
Abdominal, Subcutaneous Tissue, Edema| 3 3 3 3 3 4 2 3 3|
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | 4 3 2 3 3|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Focal | |
Dermis, Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|
DAY ON TEST | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|
| 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Thalamus, Mineralization, Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Inflammation, Chronic, Focal | 3 2 1 2 3 3 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 |
Artery, Amyloid Deposition | 3 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia, Focal | 2 |
Septum, Amyloid Deposition | 2 |
__________________________________________________________________________|
Trachea | + + + + + + I + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 1 3 4 4 1 4 4 4 4 4 4 3 4 3 3 3 4 3 3 4|
Hydronephrosis | 3 |
Metaplasia, Osseous | |
Nephropathy | 1 |
Capsule, Inflammation, Focal | |
Cortex, Atrophy, Focal | 2 |
Cortex, Atrophy | 3 |
Cortex, Cyst | X |
Cortex, Renal Tubule, Mineralization,| |
Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + M M + + M +|
Amyloid Deposition | 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|
DAY ON TEST | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|
| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + A + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Edema | 3 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 4 3 2 2 3 3 3 3 3 3|
Edema | 2 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 3 2 2 2 2 2 2|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic, Focal | 2 2 3 1 1 1 1 1 1 2 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Mesentery | + |
Polyarteritis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Focal Cellular Change | X |
Acinus, Amyloid Deposition | |
Acinus, Hypertrophy, Focal | 2 2 2 |
Interlobular, Edema | 2 2 2 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 4 3 2 2 2 2 2 3|
Inflammation, Focal, Suppurative | |
Interlobular, Edema | 3 3 3 2 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Mucosa, Degeneration | 3 |
Mucosa, Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|
DAY ON TEST | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|
| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 1 2 2 2 3 2 2 1 3 3|
Polyarteritis | 3 |
Atrium, Thrombosis | X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 3 2 3 2 3 2 3 2 2 2 3 2 3 2 2 2 2 2 2 2 3 3 3 2|
Corticomedullary Junction, Amyloid | |
Deposition | 3 3 2 3 2 3 2 3 2 3 2 3 3 |
Corticomedullary Junction, | |
Pigmentation | 2 4 2 1 3 2 2 3 3 3 2 3 2 2 4|
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 4 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M + M M M + M + + + + + + + M M M + + + M|
Amyloid Deposition | 3 2 2 2 |
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + M + + + + + +|
Necrosis | 4 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Amyloid Deposition | 2 2 1 3 2 2 2 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Follicle, Dilatation | 2 3 2 2 |
Follicular Cell, Hyperplasia | 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 3 4 3 3 2 2 2 4 2|
Atrophy | 2 3 3 3 3 3 2 2 |
Cyst | X X X X |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|
DAY ON TEST | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|
| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Hemorrhage | 4 |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | |
Angiectasis, Focal | 3 |
Hemorrhage | 4 |
Endometrium, Hyperplasia, Cystic | 4 3 3 3 3 3 3 3 3 3 3 4 3 3 3 3 4 3 3 3 3 3 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 3 2 2 3 2 2 1 |
Hematopoietic Cell Proliferation | 3 3 2 2 3 3 2 2 2 2 2 2 2 2 4 2 2 2 2 4 1 2 2 3|
Pigmentation, Hemosiderin | 2 2 2 2 2|
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + M M + + + + M M + + + + +|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + M + + + + + + + M + + + M + M + + + +|
Hyperplasia | |
Hyperplastic Alveolar Nodule | X |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Abdominal, Dermis, Inflammation, | |
Chronic | |
Abdominal, Subcutaneous Tissue, Edema| 3 3 3 4 3 3 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | 3 3 3 3 2|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate, Focal | 1 |
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|
DAY ON TEST | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|
| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Thalamus, Mineralization, Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Inflammation, Chronic, Focal | 3 3 2 2 2 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3|
Artery, Amyloid Deposition | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia, Focal | |
Septum, Amyloid Deposition | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 4 3 3 3 2 4 4 3 2 4 3 4|
Hydronephrosis | |
Metaplasia, Osseous | |
Nephropathy | 1 |
Capsule, Inflammation, Focal | |
Cortex, Atrophy, Focal | |
Cortex, Atrophy | |
Cortex, Cyst | X |
Cortex, Renal Tubule, Mineralization,| |
Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| | |
DAY ON TEST | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5| | |
| 0| 5| 7| 6| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Amyloid Deposition | | 3 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 56 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Amyloid Deposition | | 1 3.0|
Edema | | 3 3.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + | 54 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
Amyloid Deposition | 2 1 | 16 1.8|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 3 3 3 3 3 3 | 41 3.1|
Edema | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Amyloid Deposition | 2 1 | 20 1.9|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 | 27 2.1|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic, Focal | 3 2 2 1 2 | 24 1.7|
Necrosis, Focal | 2 3 | 6 2.3|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Polyarteritis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Edema | | 1 1.0|
Focal Cellular Change | | 1 |
Acinus, Amyloid Deposition | | 1 4.0|
Acinus, Hypertrophy, Focal | 2 2 | 6 2.0|
Interlobular, Edema | 3 | 14 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 1 2 1 2 | 32 2.4|
Inflammation, Focal, Suppurative | | 1 3.0|
Interlobular, Edema | 2 2 | 8 2.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| | |
DAY ON TEST | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5| | |
| 0| 5| 7| 6| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 3.0|
Mucosa, Degeneration | | 2 3.0|
Mucosa, Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 | 33 2.2|
Polyarteritis | 2 | 3 2.7|
Atrium, Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
Capsule, Hyperplasia | 2 2 2 2 2 1 2 2 2 3 | 58 2.3|
Corticomedullary Junction, Amyloid | | |
Deposition | 2 4 2 2 | 32 2.7|
Corticomedullary Junction, | | |
Pigmentation | 4 2 3 2 3 2 2 | 38 2.4|
Corticomedullary Junction, | | |
Vacuolization Cytoplasmic | 3 2 | 5 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M M + + M M | 30 |
Amyloid Deposition | 3 2 2 | 15 2.1|
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + | 54 |
Necrosis | | 1 4.0|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + M + | 56 |
Amyloid Deposition | 3 1 2 | 22 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Follicle, Dilatation | 2 | 6 2.2|
Follicular Cell, Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| | |
DAY ON TEST | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5| | |
| 0| 5| 7| 6| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 1 | 27 3.0|
Atrophy | 3 2 | 16 2.7|
Cyst | X | 9 |
Hemorrhage | | 1 4.0|
Bilateral, Hemorrhage | | 1 4.0|
Periovarian Tissue, Cyst | X | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Amyloid Deposition | | 1 3.0|
Angiectasis, Focal | | 1 3.0|
Hemorrhage | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 4 2 3 4 4 4 3 | 58 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Sternal, Myelofibrosis | 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Amyloid Deposition | | 3 1.7|
Lymphocyte, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 | 22 2.1|
Hematopoietic Cell Proliferation | 3 2 2 3 2 2 2 2 2 2 | 56 2.2|
Pigmentation, Hemosiderin | 2 1 2 2 | 17 2.0|
__________________________________________________________________________|____________|
Thymus | M + M + M + + M + + | 42 |
Amyloid Deposition | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + M | 44 |
Hyperplasia | | 2 1.0|
Hyperplastic Alveolar Nodule | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| | |
DAY ON TEST | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5| | |
| 0| 5| 7| 6| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | | 1 1.0|
Abdominal, Dermis, Inflammation, | | |
Chronic | | 1 2.0|
Abdominal, Subcutaneous Tissue, Edema| 3 3 | 17 3.1|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Dermis, Inflammation, Chronic | 1 | 3 1.7|
Subcutaneous Tissue, Edema | 2 3 | 12 2.8|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Exudate, Focal | | 1 1.0|
Dermis, Inflammation, Chronic | 1 | 2 1.5|
Subcutaneous Tissue, Edema | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage, Focal | | 1 2.0|
Thalamus, Mineralization, Focal | 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 | 4 2.5|
Inflammation, Chronic, Focal | 2 2 | 14 2.3|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | | 2 3.0|
Artery, Amyloid Deposition | | 1 3.0|
Interstitium, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Glands, Hyperplasia, Focal | | 1 2.0|
Septum, Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| | |
DAY ON TEST | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5| | |
| 0| 5| 7| 6| 5| 5| 5| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 4 1 1 3 2 | 42 3.2|
Hydronephrosis | | 1 3.0|
Metaplasia, Osseous | 2 | 1 2.0|
Nephropathy | | 2 1.0|
Capsule, Inflammation, Focal | 3 | 1 3.0|
Cortex, Atrophy, Focal | | 1 2.0|
Cortex, Atrophy | | 1 3.0|
Cortex, Cyst | | 2 |
Cortex, Renal Tubule, Mineralization,| | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 56 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|
| 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
Amyloid Deposition | |
Polyarteritis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M M + + + + A + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 1 2 2 2 2 2|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 3 4 4 3 4 4 3 4 4 4 3 3 3 4 4|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Amyloid Deposition | 2 1 1 3 2 1 3 3 2 2 4 2 2 3 2 2 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 2 2 2 3 3 2 2 2 3 2 2 2 2 2|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic, Focal | 1 2 1 1 2 2 2 2 2|
Necrosis, Focal | 2 |
Necrosis | 4 |
Centrilobular, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Polyarteritis | |
Acinus, Hypertrophy, Focal | 2 |
Interlobular, Edema | 2 3 2 2 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 3 3 3 4 3 3 2 3 3 3 3|
Inflammation, Chronic | 2 |
Interlobular, Edema | 3 3 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Submucosa, Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|
| 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 1 2 1 2 3 2 3 3 3 3 2 3 3 3 2|
Polyarteritis | |
Atrium, Inflammation, Suppurative | 4 |
Atrium, Thrombosis | X |
Myocardium, Inflammation, Focal, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 2 3 2 3 2 2 2 2 2 3 2 3 2 2 2 2 3 3 3 2 2|
Corticomedullary Junction, Amyloid | |
Deposition | 1 2 2 2 2 3 4 2 3 2 4 3 3 2 4|
Corticomedullary Junction, | |
Pigmentation | 2 3 2 3 2 4 2 3 2 4 2 3 3 3 2|
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M + + M + + + M A + + + M M + M M + + M M|
Amyloid Deposition | 2 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + M M + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 3 3 3 3 3|
Inflammation, Chronic | 2 |
C-Cell, Hyperplasia | |
Follicle, Dilatation | 2 3 3 2 3 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Granuloma | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 3 4 3 4 4 2 3 2 3 4 4 4 3 4 3|
Atrophy | 3 4 3 4 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|
| 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X X X |
Hematocyst | |
Hemorrhage | 3 3 3|
Follicle, Cyst | |
Periovarian Tissue, Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | |
Cervix, Hypertrophy | |
Cervix, Inflammation, Subacute | |
Endometrium, Hyperplasia, Cystic | 3 4 3 4 4 3 3 3 4 3 3 3 3 3 3 3 3 4 4 3 3 4 4 2|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 3 |
Sternal, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Amyloid Deposition | 2 2 |
Granuloma | |
Hyperplasia, Lymphoid | |
Hyperplasia | 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 2 2 2 4 1 2 2 2|
Hematopoietic Cell Proliferation | 3 2 3 1 2 2 4 2 2 2 3 2 2 2 3 3 1 2 3 3 2 2 2 2|
Hyperplasia, Lymphoid | 3 |
Pigmentation, Hemosiderin | 3 2 2 3 2|
__________________________________________________________________________|
Thymus | + + M I + + + + + + + + + + + + + M + + M M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + M + M + + + + + + + M M + + M + + M M|
Hyperplasia | 3 |
Hyperplastic Alveolar Nodule | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Dermis, Inflammation, | |
Chronic | |
Abdominal, Subcutaneous Tissue, Edema| 2 2 3 2 4 2 3 2 2|
Neck, Ulcer | 4 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|
| 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | |
Subcutaneous Tissue, Edema | 2 1 3 3|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Ulcer | 2 |
Dermis, Inflammation, Chronic | 1 2 2 2|
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 4 3|
Interstitium, Inflammation, Chronic | 3 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
__________________________________________________________________________|
Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Anterior Chamber, Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Amyloid Deposition | 4 3 3 4 4 3 3 4 4 2 4 4 4 3 4 3 4 4|
Hydronephrosis | |
Nephropathy | 1 2 |
Cortex, Atrophy, Focal | |
Cortex, Cyst | X |
Pelvis, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|
DAY ON TEST | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|
| 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|
| 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + M + + A + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Polyarteritis | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + A + + + + + +|
Amyloid Deposition | 2 1 2 1 1 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 4 4 4 3 4 3 4 4 4 3 4|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + A + + + + + +|
Amyloid Deposition | 3 3 4 2 3 2 1 3|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 2 2 2 2 2 2 2 3 2|
Clear Cell Focus | X |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic, Focal | 1 2 2 2 2 2 1 2 2 |
Necrosis, Focal | 2 |
Necrosis | |
Centrilobular, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | |
Hemorrhage, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Polyarteritis | 2 |
Acinus, Hypertrophy, Focal | |
Interlobular, Edema | 3 3 3 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 3 3 2 3 4 3 2 3 3 3 1 |
Inflammation, Chronic | |
Interlobular, Edema | 3 3 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Submucosa, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|
| 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 1 2 1 3 2 2 1 1|
Polyarteritis | 2 |
Atrium, Inflammation, Suppurative | |
Atrium, Thrombosis | X X|
Myocardium, Inflammation, Focal, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 2 2 2 2 3 3 2 2 2 3 3 3 3 3 3 3 3 2 2 2 2 |
Corticomedullary Junction, Amyloid | |
Deposition | 3 2 3 3 3 3 2 4 2 3 3 4 2 3|
Corticomedullary Junction, | |
Pigmentation | 3 3 2 2 3 2 3 1 3 4 2 2 2 |
Corticomedullary Junction, | |
Vacuolization Cytoplasmic | 3 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M + + + M M M + M M M + M M M + + M M + M M|
Amyloid Deposition | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Amyloid Deposition | 3 2 2 2 1 |
Inflammation, Chronic | |
C-Cell, Hyperplasia | 1 |
Follicle, Dilatation | 2 3 2 |
Follicular Cell, Hyperplasia | 2 1 1 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Granuloma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Amyloid Deposition | 4 4 4 4 2 4 2 3 3 2 4 |
Atrophy | 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|
| 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X X X X X X |
Hematocyst | X |
Hemorrhage | |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Amyloid Deposition | 3 |
Cervix, Hypertrophy | 3 |
Cervix, Inflammation, Subacute | 3 |
Endometrium, Hyperplasia, Cystic | 3 4 3 4 3 3 4 2 3 4 4 4 4 3 3 4 4 3 3 3 4 4 4|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | |
Sternal, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Granuloma | 4 |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 2 2 |
Hematopoietic Cell Proliferation | 1 2 2 3 2 2 3 3 2 2 2 2 3 2 2 3 3 3 4 2 3 1|
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 2 2 2 3 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + M + I M M + + + + + + + + I + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M M M + + M + + M M M + + + + + M|
Hyperplasia | |
Hyperplastic Alveolar Nodule | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abdominal, Dermis, Inflammation, | |
Chronic | 2 |
Abdominal, Subcutaneous Tissue, Edema| 3 2 3 3 2 3 3 2 |
Neck, Ulcer | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|
| 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperkeratosis | 1 |
Subcutaneous Tissue, Edema | 2 2 3|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Ulcer | |
Dermis, Inflammation, Chronic | 2 2 |
Subcutaneous Tissue, Edema | 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage | 2 3 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 1 |
Interstitium, Inflammation, Chronic | 4 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Hemorrhage | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 4 3 4 2 4 2 4 4 4 4 3 4 4 4 3 4|
Hydronephrosis | 4 |
Nephropathy | 2 2 |
Cortex, Atrophy, Focal | 2 |
Cortex, Cyst | |
Pelvis, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|
DAY ON TEST | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|
| 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + M + + + M + M + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | |
DAY ON TEST | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0| | |
| 6| 8| 6| 1| 2| 2| 2| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M M + | 54 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A A + | 56 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + | 57 |
Amyloid Deposition | | 1 4.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A A + | 53 |
Amyloid Deposition | 2 3 2 | 19 1.9|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A A + | 56 |
Amyloid Deposition | 3 3 3 4 4 4 | 38 3.5|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A A + | 55 |
Amyloid Deposition | 1 3 4 | 28 2.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 2 2 2 2 | 33 2.1|
Clear Cell Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
Inflammation, Chronic, Focal | 2 1 1 2 1 1 | 24 1.6|
Necrosis, Focal | 2 | 3 2.0|
Necrosis | | 1 4.0|
Centrilobular, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Focal Cellular Change | X | 3 |
Polyarteritis | | 1 2.0|
Acinus, Hypertrophy, Focal | | 1 2.0|
Interlobular, Edema | 2 2 | 15 2.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 2 3 3 | 32 2.8|
Inflammation, Chronic | | 1 2.0|
Interlobular, Edema | 3 2 3 | 11 2.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | |
DAY ON TEST | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0| | |
| 6| 8| 6| 1| 2| 2| 2| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Ulcer | | 1 2.0|
Submucosa, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 1 | 31 2.0|
Polyarteritis | | 1 2.0|
Atrium, Inflammation, Suppurative | | 1 4.0|
Atrium, Thrombosis | | 3 |
Myocardium, Inflammation, Focal, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
Capsule, Hyperplasia | 2 3 3 2 2 2 3 2 2 | 55 2.4|
Corticomedullary Junction, Amyloid | | |
Deposition | 3 2 3 3 | 33 2.7|
Corticomedullary Junction, | | |
Pigmentation | 2 4 4 2 4 | 33 2.7|
Corticomedullary Junction, | | |
Vacuolization Cytoplasmic | 3 2 | 6 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 2 3.0|
Hypertrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M + M + M | 25 |
Amyloid Deposition | 3 2 | 8 2.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 56 |
Pars Distalis, Cyst | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 1 2 | 17 2.3|
Inflammation, Chronic | 1 | 2 1.5|
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Dilatation | 2 | 10 2.4|
Follicular Cell, Hyperplasia | 2 2 | 9 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | |
DAY ON TEST | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0| | |
| 6| 8| 6| 1| 2| 2| 2| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Granuloma | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Abscess | | 1 4.0|
Amyloid Deposition | 3 3 4 4 3 | 31 3.3|
Atrophy | 3 3 3 | 10 3.1|
Cyst | X | 13 |
Hematocyst | | 1 |
Hemorrhage | | 3 3.0|
Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | X | 12 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Abscess | | 1 4.0|
Amyloid Deposition | | 1 3.0|
Cervix, Hypertrophy | | 1 3.0|
Cervix, Inflammation, Subacute | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 4 3 3 4 3 3 3 3 | 58 3.4|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Calvarium, Myelofibrosis | | 1 3.0|
Sternal, Myelofibrosis | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hyperplasia, Plasma Cell | | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + | 58 |
Amyloid Deposition | | 3 2.0|
Granuloma | | 1 4.0|
Hyperplasia, Lymphoid | 3 | 3 2.7|
Hyperplasia | | 3 3.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 3 | 19 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | |
DAY ON TEST | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0| | |
| 6| 8| 6| 1| 2| 2| 2| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 2 1 2 | 56 2.3|
Hyperplasia, Lymphoid | | 2 2.5|
Pigmentation, Hemosiderin | 2 2 3 2 2 2 | 24 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + I | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + M | 42 |
Hyperplasia | | 1 3.0|
Hyperplastic Alveolar Nodule | | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abdominal, Dermis, Inflammation, | | |
Chronic | | 1 2.0|
Abdominal, Subcutaneous Tissue, Edema| 2 3 3 | 21 2.5|
Neck, Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 1.0|
Subcutaneous Tissue, Edema | 2 3 | 9 2.3|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Ulcer | | 1 2.0|
Dermis, Inflammation, Chronic | 2 | 7 1.9|
Subcutaneous Tissue, Edema | 2 3 | 6 2.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization, Focal | 1 2 | 13 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 | 2 2.0|
Hemorrhage | | 3 2.3|
Inflammation, Chronic, Focal | 2 | 4 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 4.0|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | |
DAY ON TEST | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0| | |
| 6| 8| 6| 1| 2| 2| 2| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HF | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal, Histiocyte | 2 | 6 2.7|
Interstitium, Inflammation, Chronic | 2 2 2 | 7 2.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Anterior Chamber, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Amyloid Deposition | 2 4 2 4 3 4 4 | 41 3.5|
Hydronephrosis | | 1 4.0|
Nephropathy | 1 | 5 1.6|
Cortex, Atrophy, Focal | | 1 2.0|
Cortex, Cyst | | 1 |
Pelvis, Dilatation | 1 3 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|
DAY ON TEST | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|
| 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Gallbladder | + M + + + A + M + + + + + + + + + + + M A + + M +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + M A A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + M + + + + + + A A + + + +|
Edema | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Abscess | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + A + + + + +|
Amyloid Deposition | 2 4 2 2 3 4 2 3 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + A + + + + +|
Amyloid Deposition | 3 3 4 3 3 3 3 4 2 3 2 3 4 4 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + A + + + + +|
Amyloid Deposition | 3 2 3 2 3 2 2 2 3 3 4 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 2 2 2 3 3 2 2 1 3 2 |
Degeneration, Fatty | |
Inflammation, Chronic, Focal | 1 2 2 1 2 1 2 2 |
Mitotic Alteration | |
Necrosis, Focal | 3 |
Centrilobular, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | + |
Granuloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Acinus, Amyloid Deposition | 3 |
Acinus, Hypertrophy, Focal | 2 |
Interlobular, Edema | 2 2 2 3 3 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 3 4 3 2 2 2 2 |
Infarct | |
Inflammation, Chronic | |
Interlobular, Edema | 4 2 2 3 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Acanthosis | |
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|
DAY ON TEST | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|
| 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 1 2 4 4 4 1 2 3 2 |
Inflammation, Chronic, Focal | |
Atrium, Thrombosis | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 1 2 1 2 3 2 2 2 2 3 2 3 2 |
Corticomedullary Junction, Amyloid | |
Deposition | 2 3 4 2 3 4 2 3 3 3 3 1 4 2 |
Corticomedullary Junction, | |
Pigmentation | 3 2 3 3 2 3 2 2 3 2 3 3 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M M M M M + M + M M + M M + + M M + M M +|
Amyloid Deposition | 4 4 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + M M + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 3 2 3 2 1 4 3 1 3 3 3 |
C-Cell, Hyperplasia | |
Follicle, Dilatation | 3 1 3 3 3 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Necrosis | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|
DAY ON TEST | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|
| 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Dilatation | 4 2 2 3 |
Hemorrhage | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + I + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 |
Seminiferous Tubule, Atrophy | 4 |
Seminiferous Tubule, Degeneration | 3 3 2 |
Seminiferous Tubule, Mineralization | 3 |
Seminiferous Tubule, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + + + + + + + + + + + + + + + M + + +|
Amyloid Deposition | |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + A + + + +|
Amyloid Deposition | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Polyarteritis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 4 4 3 4 4 3 1 3 2 4 4 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 3 2 2 2 3 1 2 2 2|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thymus | + M + + + I + A + + + + M + + + + + + A + + + M +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + + M M M M M M + M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Abdominal, Edema | 2 |
Abdominal, Subcutaneous Tissue, Edema| 2 2 2 1 2 3 2 3 |
Neck, Ulcer | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|
DAY ON TEST | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|
| 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Edema | 2 2 2 2 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Subcutaneous Tissue, Edema | 2 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2|
Foreign Body | 2 |
Hemorrhage | 3 |
Inflammation, Chronic, Focal | 3 3 3 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 3 |
Artery, Amyloid Deposition | 3 3 2 |
Interstitium, Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Foreign Body | 4 |
Fungus | 2 |
__________________________________________________________________________|
Trachea | + M + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Ulcer | |
__________________________________________________________________________|
Eye | + |
Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 4 4 3 4 1 4 4 4 4 1 4 2 4 2 4 |
Nephropathy | 2 2 2 |
Cortex, Atrophy, Focal | 3 |
Cortex, Cyst | |
Cortex, Renal Tubule, Mineralization,| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|
DAY ON TEST | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|
| 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Focal | 2 2 2|
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|
DAY ON TEST | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|
| 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + M + + + + + + M + + + +|
Inflammation, Chronic | 3|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + M + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Abscess | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 1 1 2 2 1 1 2 2 2 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 2 3 3 3 4 4 4 4 3 2 4 3 3 3|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + A + + + +|
Amyloid Deposition | 3 2 1 1 3 2 4 2 2 2 3 2 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 2 2 2 3 2 3 2 2 2 2 2 3 2|
Degeneration, Fatty | |
Inflammation, Chronic, Focal | 2 1 1 1 1 |
Mitotic Alteration | 2 |
Necrosis, Focal | 3 |
Centrilobular, Hypertrophy | 3 |
__________________________________________________________________________|
Mesentery | + |
Granuloma | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Acinus, Amyloid Deposition | |
Acinus, Hypertrophy, Focal | |
Interlobular, Edema | 3 1 2 4 3 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 3 4 2 4 3 1 3 2 2 1 4 3|
Infarct | |
Inflammation, Chronic | 2 |
Interlobular, Edema | 4 4 2 4 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|
DAY ON TEST | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|
| 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 3 4 2 4 2 2 2 3 3 2 2 1 3 2 2|
Inflammation, Chronic, Focal | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 3 3 1 2 2 2 2 2 2 2 2 2 2 1 2 2 4 2 3 3|
Corticomedullary Junction, Amyloid | |
Deposition | 3 3 2 2 3 3 2 3 1 3 4 3 3 3 2 3 4 2|
Corticomedullary Junction, | |
Pigmentation | 2 2 3 4 4 3 3 2 2 2 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + + + + M + + M M M M + M + M M + + M|
Amyloid Deposition | 3 2 4 1 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + I + + + M + + + + + + I +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 3 1 2 3 2 2 2 2 3 3 1 2 3 2|
C-Cell, Hyperplasia | |
Follicle, Dilatation | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Necrosis | 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|
DAY ON TEST | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|
| 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + M + + + + + + + I|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Dilatation | 3 |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Degeneration | |
Seminiferous Tubule, Mineralization | |
Seminiferous Tubule, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Amyloid Deposition | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Polyarteritis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 3 3 4 4 3 3 2 2 1 3 |
Hematopoietic Cell Proliferation | 2 2 3 2 4 2 3 2 2 3 2 2 2 2 2 2 2 3|
Hyperplasia, Lymphoid | 3 |
Pigmentation, Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thymus | + I + + + + + M + + + + + + + + M + + M + + + + +|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M + M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Abdominal, Edema | |
Abdominal, Subcutaneous Tissue, Edema| 2 3 2 2 2 3 3 3 |
Neck, Ulcer | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|
DAY ON TEST | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|
| 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Edema | 2 3 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Subcutaneous Tissue, Edema | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 2 2 2 2 1 1 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Hemorrhage | |
Inflammation, Chronic, Focal | 2 3 3 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 |
Artery, Amyloid Deposition | 2 |
Interstitium, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Foreign Body | 4 2 |
Fungus | |
__________________________________________________________________________|
Trachea | + + + + I + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Ulcer | 4 |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 4 4 4 4 3 4 4 4 4 3 4 4 3 4 4 2|
Nephropathy | 2 2|
Cortex, Atrophy, Focal | 3 3 |
Cortex, Cyst | X X X |
Cortex, Renal Tubule, Mineralization,| |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|
DAY ON TEST | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|
| 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Focal | 1 |
Pelvis, Dilatation | 3 |
__________________________________________________________________________|
Urethra | + +|
Bulbourethral Gland, Dilatation | 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + A + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 3 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
DAY ON TEST | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5| | |
| 7| 5| 5| 3| 4| 4| 4| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 51 |
Inflammation, Chronic | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 55 |
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
Mucosa, Abscess | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
Amyloid Deposition | 2 2 3 2 4 | 27 2.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + + + + + + | 56 |
Amyloid Deposition | 3 3 4 3 4 3 | 37 3.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Amyloid Deposition | 2 2 3 2 4 | 30 2.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 2 2 2 | 34 2.2|
Degeneration, Fatty | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 1 2 3 1 | 18 1.6|
Mitotic Alteration | | 1 2.0|
Necrosis, Focal | | 2 3.0|
Centrilobular, Hypertrophy | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Granuloma | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Focal Cellular Change | X | 2 |
Acinus, Amyloid Deposition | | 1 3.0|
Acinus, Hypertrophy, Focal | | 1 2.0|
Interlobular, Edema | 2 3 | 17 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 3 3 | 29 2.7|
Infarct | 4 | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Interlobular, Edema | | 11 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
DAY ON TEST | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5| | |
| 7| 5| 5| 3| 4| 4| 4| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Acanthosis | | 1 1.0|
Amyloid Deposition | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 3 2 2 3 3 | 35 2.5|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Atrium, Thrombosis | X X | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
Capsule, Hyperplasia | 2 3 2 2 2 2 2 3 2 | 44 2.2|
Corticomedullary Junction, Amyloid | | |
Deposition | 2 2 2 3 4 | 37 2.7|
Corticomedullary Junction, | | |
Pigmentation | 3 4 1 3 2 2 | 33 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Hyperplasia, Focal | 3 | 3 2.7|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | I M M + + + M M M M | 24 |
Amyloid Deposition | 4 2 | 12 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 54 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Amyloid Deposition | 4 2 2 3 | 33 2.4|
C-Cell, Hyperplasia | 2 | 1 2.0|
Follicle, Dilatation | 3 3 | 11 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
DAY ON TEST | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5| | |
| 7| 5| 5| 3| 4| 4| 4| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 3.0|
Necrosis | | 1 4.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Abscess | 3 | 1 3.0|
Cyst | | 1 |
__________________________________________________________________________|____________|
Prostate | + M + + + + + + + + | 56 |
Inflammation, Chronic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Concretion | 3 | 1 3.0|
Dilatation | 3 | 6 2.8|
Hemorrhage | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Interstitial Cell, Hyperplasia | | 1 3.0|
Seminiferous Tubule, Atrophy | 2 2 | 3 2.7|
Seminiferous Tubule, Degeneration | | 3 2.7|
Seminiferous Tubule, Mineralization | | 1 3.0|
Seminiferous Tubule, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Calvarium, Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Amyloid Deposition | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 57 |
Amyloid Deposition | 3 | 4 2.3|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Polyarteritis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 4 3 3 2 | 30 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
DAY ON TEST | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5| | |
| 7| 5| 5| 3| 4| 4| 4| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 4 2 2 2 2 2 2 3 2 | 46 2.2|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation, Hemosiderin | 2 1 | 8 1.9|
__________________________________________________________________________|____________|
Thymus | + M M + M + + + M + | 46 |
Amyloid Deposition | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | | 1 1.0|
Abdominal, Edema | | 1 2.0|
Abdominal, Subcutaneous Tissue, Edema| 3 | 18 2.3|
Neck, Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Dermis, Inflammation, Chronic | | 2 2.0|
Subcutaneous Tissue, Edema | | 7 2.1|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Subcutaneous Tissue, Edema | 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization, Focal | 2 | 19 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.5|
Foreign Body | | 1 2.0|
Hemorrhage | 2 | 2 2.5|
Inflammation, Chronic, Focal | 2 1 3 3 | 13 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 5 2.4|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 3 2 1 | 6 2.3|
Artery, Amyloid Deposition | | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| | |
DAY ON TEST | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5| | |
| 7| 5| 5| 3| 4| 4| 4| 2| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
VM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Inflammation, Chronic | 3 | 4 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 1 |
Foreign Body | 3 | 4 3.3|
Fungus | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 4 4 3 4 4 2 | 44 3.5|
Nephropathy | 1 1 | 7 1.7|
Cortex, Atrophy, Focal | 3 | 4 3.0|
Cortex, Cyst | X X X | 6 |
Cortex, Renal Tubule, Mineralization,| | |
Focal | | 4 1.8|
Pelvis, Dilatation | | 2 2.5|
__________________________________________________________________________|____________|
Urethra | | 2 |
Bulbourethral Gland, Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Amyloid Deposition | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|
| 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + A + + + + + M + M + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + M + + A + + A + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + A + + + + + + + + + A + + + + +|
Amyloid Deposition | 2 |
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + A + + + + + + + + + A + + + + +|
Amyloid Deposition | |
Edema | 3 3 3 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + A + + + + + + + + + A + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 3 |
Intussusception | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + A + + + + + + + + + A + + + + +|
Amyloid Deposition | 3 2 3 3 3 3 3 2 3 4 4 3 3 4 3|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + A + + + + + + + + + A + + + + +|
Amyloid Deposition | 3 2 2 2 3 1 2 2 1 2 3 2 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 3 2 1 2 2 3 3 1 1 2 2 2|
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic, Focal | 2 2 2 1 1 2 2 2 |
Necrosis, Focal | 1 |
Pigmentation | 2 |
Centrilobular, Hypertrophy | 2 |
__________________________________________________________________________|
Mesentery | +|
Polyarteritis | 4|
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition, Focal | 3 |
Focal Cellular Change | |
Acinus, Amyloid Deposition | |
Acinus, Hyperplasia, Focal | |
Acinus, Hypertrophy, Focal | 2 |
Interlobular, Edema | 2 2 3 2 3 2 3 3 2 2 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 3 2 3 3 3 4 4 4 3 3 2 4 3|
Interlobular, Edema | 3 3 3 2 3 2 3 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pylorus, Amyloid Deposition | |
Submucosa, Edema | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|
| 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 |
Submucosa, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 3 3 2 1 2 2 3 2 3 2 2|
Atrium, Thrombosis | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 3 3 2 3 2 2 2 2 2 3 3 2 2|
Corticomedullary Junction, Amyloid | |
Deposition | 2 2 2 3 3 2 3 3 2 2 3 2 2 2 3|
Corticomedullary Junction, | |
Pigmentation | 2 2 2 2 2 2 3 3 2 3 3 2 3 3 4 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 2 |
Hypoplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M M + M M M + M M M M I M M M M + + + M +|
Amyloid Deposition | 4 1 2 2 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + A + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + M + + + + +|
Amyloid Deposition | 3 4 3 2 1 3 3 3 2 3|
Inflammation, Chronic | |
Follicle, Dilatation | 2 2 |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + A + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 2 |
Fat, Inflammation, Focal, Suppurative| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|
| 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + M + + + + + + A + + + + + + + M + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + A + + + + + + + + + + + + + + +|
Concretion | |
Dilatation | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + A + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Seminiferous Tubule, Atrophy | 2 3 3 |
Seminiferous Tubule, Degeneration | |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition | 3|
Granuloma | |
Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 3 1 2 1 1 3 3 4 3 |
Hematopoietic Cell Proliferation | 2 1 3 2 3 2 2 2 2 2 3 2 3 2 2 3 4 2 2 2|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + A + I + + + + + M + + + M + + +|
Abscess | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M A M M M M M + M M M M M + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Exudate, Focal | |
Abdominal, Dermis, Inflammation, | |
Chronic | |
Abdominal, Subcutaneous Tissue, Edema| 3 3 3 3 3 4 3 2 3 2 3 |
Face, Acanthosis | |
Face, Exudate | |
Forelimb, Right, Ulcer | |
Head, Ventral, Ulcer | |
Neck, Acanthosis | |
Neck, Fungus | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|
| 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Neck, Inflammation, Subacute | |
Neck, Ulcer | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 2 3 2 3 3 3 2 2 2 3|
Subcutaneous Tissue, Hemorrhage | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Ulcer | |
Dermis, Inflammation, Chronic | 1 1 |
Subcutaneous Tissue, Edema | 3 3 2 2 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2|
Thalamus, Mineralization, Focal | 1 2 3 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition, Focal | |
Congestion | 3 3 |
Hemorrhage | 3 |
Inflammation, Chronic, Focal | 3 3 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 |
Artery, Amyloid Deposition | |
Interstitium, Inflammation, Chronic | 2 2 2 2 1 2 |
Vein, Embolus | |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + I +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|
DAY ON TEST | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|
| 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Ulcer | 4 |
Bilateral, Ulcer | |
External Ear, Acanthosis | 4 |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 3 3 2 3 4 3 4 3 4 4 4 4 3 3 3 4 4|
Hydronephrosis | |
Inflammation, Suppurative | |
Nephropathy | 1 |
Cortex, Atrophy, Focal | |
Cortex, Cyst | X X |
Cortex, Renal Tubule, Mineralization,| |
Focal | 2 2 |
Pelvis, Dilatation | 2 3 |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + A + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Crystals | 2 |
Mucosa, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|
DAY ON TEST | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|
| 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Gallbladder | A M M + A + M + M + + + + + + + + A + + M + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + + + + + + + + + + + + A + + + + A + +|
Amyloid Deposition | 2 |
Edema | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A M + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | |
Edema | 3 3 3 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + A + + + + + + M + + + + + A + + + + M + M|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + M + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 2 2 2 2 4 3 2 2 2 |
Intussusception | X |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 3 4 3 4 3 3 3 3 2 3 2 3 3 3 3 4 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + M + + + + A + + + + A + + + + + + +|
Amyloid Deposition | 2 3 2 2 3 2 2 2 2 3 3 4 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 2 2 3 2 2 2 2 2 3 3 3 3 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic, Focal | 1 2 2 |
Necrosis, Focal | |
Pigmentation | |
Centrilobular, Hypertrophy | 2|
__________________________________________________________________________|
Mesentery | + |
Polyarteritis | |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition, Focal | |
Focal Cellular Change | X |
Acinus, Amyloid Deposition | |
Acinus, Hyperplasia, Focal | 2 |
Acinus, Hypertrophy, Focal | 3 |
Interlobular, Edema | 3 2 3 2 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 3 2 3 3 4 3 3 4 3 4 2 3 3 2 3 2 |
Interlobular, Edema | 3 3 2 3 4 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
Pylorus, Amyloid Deposition | 3 |
Submucosa, Edema | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|
DAY ON TEST | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|
| 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 2 2 |
Submucosa, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Polyarteritis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 3 4 3 2 3 3 4 2 2 2 3 2 2 3 3 |
Atrium, Thrombosis | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 1 3 2 3 2 2 2 2 2 |
Corticomedullary Junction, Amyloid | |
Deposition | 4 3 2 3 2 2 4 4 3 2 2 2 4 3 2 2 |
Corticomedullary Junction, | |
Pigmentation | 3 2 2 2 1 3 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hypertrophy, Focal | |
Hypoplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + M + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + M + + M M + M M + M M + M + + + M +|
Amyloid Deposition | 2 2 1 2 2 |
__________________________________________________________________________|
Pituitary Gland | I + + M + + + + M + + + + + + + + M + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 2 3 2 2 2 2 2 1 2 2 3 2 2 2 |
Inflammation, Chronic | 2 2 |
Follicle, Dilatation | 2 3 3 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + A + + + + + + +|
Edema | 3 |
Inflammation, Chronic | 2 2 |
Fat, Inflammation, Focal, Suppurative| 4 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | A |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|
DAY ON TEST | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|
| 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + M M + + + + + + + + + A + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + M A + + + + + + +|
Concretion | 3 |
Dilatation | 2 1 3 3 2 |
Inflammation, Chronic | 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + A + + + + + + +|
Granuloma Sperm | 2 |
Seminiferous Tubule, Atrophy | 3 3 2 3 |
Seminiferous Tubule, Degeneration | 3 |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + A + + + + + + M|
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 2 2 2 |
Granuloma | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | 2 3 2 2 3 2 1 2 3 4 2 1 2 3 2 2 |
Hematopoietic Cell Proliferation | 3 3 2 2 3 2 2 2 2 2 2 4 2 2 2 2 3 3 2 2 2|
Hyperplasia, Lymphoid | 3 |
Pigmentation, Hemosiderin | 2 2 2 2 |
__________________________________________________________________________|
Thymus | + I + + + + + + + + M + + + + + M A + + + + M M +|
Abscess | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M M M M M M M A M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Exudate, Focal | 2 |
Abdominal, Dermis, Inflammation, | |
Chronic | 2 |
Abdominal, Subcutaneous Tissue, Edema| 4 3 4 3 2 3 3 2 |
Face, Acanthosis | 2 |
Face, Exudate | 2 |
Forelimb, Right, Ulcer | |
Head, Ventral, Ulcer | |
Neck, Acanthosis | 2 |
Neck, Fungus | 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|
DAY ON TEST | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|
| 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Neck, Inflammation, Subacute | 4 |
Neck, Ulcer | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | 3 3 2 2 3 2 |
Subcutaneous Tissue, Hemorrhage | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Ulcer | 2 |
Dermis, Inflammation, Chronic | 3 |
Subcutaneous Tissue, Edema | 4 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + A + + + + + + +|
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
Thalamus, Mineralization, Focal | 1 2 3 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition, Focal | 2 3 |
Congestion | 3 3 2 |
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 2 3 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 |
Artery, Amyloid Deposition | |
Interstitium, Inflammation, Chronic | 4 2 1 2 |
Vein, Embolus | 4|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + M + + + + + + + + + + + + + + I A + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|
DAY ON TEST | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|
| 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
40 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Ulcer | |
Bilateral, Ulcer | |
External Ear, Acanthosis | |
__________________________________________________________________________|
Eye | + M |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 3 4 3 3 4 4 3 4 4 3 2 4 4 4 |
Hydronephrosis | |
Inflammation, Suppurative | 4 |
Nephropathy | 1 4 2 |
Cortex, Atrophy, Focal | 3 |
Cortex, Cyst | X X X X X |
Cortex, Renal Tubule, Mineralization,| |
Focal | |
Pelvis, Dilatation | 2 2 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 4 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + A + + M + + + +|
Amyloid Deposition | |
Crystals | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 5| 5| 1| 5| 5| 5| | |
DAY ON TEST | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4| | |
| 9| 6| 5| 5| 2| 2| 1| 8| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 53 |
Amyloid Deposition | | 2 2.0|
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 54 |
Amyloid Deposition | 3 | 1 3.0|
Edema | | 7 2.9|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 51 |
Amyloid Deposition | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 54 |
Amyloid Deposition | 2 4 3 2 2 3 | 19 2.4|
Intussusception | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
Amyloid Deposition | 3 3 4 4 3 3 3 4 | 40 3.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + M + + + + + + + + | 51 |
Amyloid Deposition | 2 2 1 2 2 4 | 32 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Amyloid Deposition | 2 3 3 3 1 2 2 2 | 41 2.2|
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Chronic, Focal | 2 | 12 1.8|
Necrosis, Focal | | 1 1.0|
Pigmentation | | 1 2.0|
Centrilobular, Hypertrophy | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Polyarteritis | | 1 4.0|
Fat, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Amyloid Deposition, Focal | | 1 3.0|
Focal Cellular Change | | 1 |
Acinus, Amyloid Deposition | 3 | 1 3.0|
Acinus, Hyperplasia, Focal | | 1 2.0|
Acinus, Hypertrophy, Focal | | 2 2.5|
Interlobular, Edema | 2 3 2 2 | 23 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
Amyloid Deposition | 3 3 2 3 2 2 3 3 | 39 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 5| 5| 1| 5| 5| 5| | |
DAY ON TEST | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4| | |
| 9| 6| 5| 5| 2| 2| 1| 8| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Interlobular, Edema | | 14 2.9|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
Pylorus, Amyloid Deposition | | 1 3.0|
Submucosa, Edema | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Amyloid Deposition | 2 | 5 2.0|
Submucosa, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Polyarteritis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 4 3 4 1 3 2 2 | 41 2.5|
Atrium, Thrombosis | X X X X X | 16 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 58 |
Capsule, Hyperplasia | 2 2 2 2 2 | 37 2.2|
Corticomedullary Junction, Amyloid | | |
Deposition | 2 2 3 2 2 2 3 2 | 39 2.5|
Corticomedullary Junction, | | |
Pigmentation | 2 2 2 2 | 28 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 58 |
Hypertrophy, Focal | | 1 2.0|
Hypoplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M M + M M + M | 25 |
Amyloid Deposition | 2 4 2 | 13 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 54 |
Pars Distalis, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 56 |
Amyloid Deposition | 3 4 4 3 2 2 | 30 2.5|
Inflammation, Chronic | | 2 2.0|
Follicle, Dilatation | 2 | 7 2.3|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 5| 5| 1| 5| 5| 5| | |
DAY ON TEST | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4| | |
| 9| 6| 5| 5| 2| 2| 1| 8| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
Edema | | 1 3.0|
Inflammation, Chronic | | 3 2.0|
Fat, Inflammation, Focal, Suppurative| | 1 4.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 54 |
Hyperplasia, Focal | 2 | 2 2.0|
Inflammation, Chronic | 2 | 3 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 57 |
Concretion | | 1 3.0|
Dilatation | 2 | 6 2.2|
Inflammation, Chronic | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Granuloma Sperm | | 1 2.0|
Seminiferous Tubule, Atrophy | 3 | 8 2.8|
Seminiferous Tubule, Degeneration | | 1 3.0|
Seminiferous Tubule, Mineralization | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Hyperplasia, Plasma Cell | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Amyloid Deposition | 2 | 5 2.2|
Granuloma | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Amyloid Deposition | 4 4 4 4 2 3 | 33 2.6|
Hematopoietic Cell Proliferation | 1 2 2 2 3 2 2 2 | 49 2.3|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation, Hemosiderin | | 9 2.0|
__________________________________________________________________________|____________|
Thymus | M M I + + I + + + + | 45 |
Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 5| 5| 1| 5| 5| 5| | |
DAY ON TEST | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4| | |
| 9| 6| 5| 5| 2| 2| 1| 8| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | | 1 1.0|
Exudate, Focal | | 1 2.0|
Abdominal, Dermis, Inflammation, | | |
Chronic | | 1 2.0|
Abdominal, Subcutaneous Tissue, Edema| 3 2 3 2 3 | 24 2.9|
Face, Acanthosis | | 1 2.0|
Face, Exudate | | 1 2.0|
Forelimb, Right, Ulcer | 4 | 1 4.0|
Head, Ventral, Ulcer | 4 | 1 4.0|
Neck, Acanthosis | | 1 2.0|
Neck, Fungus | | 1 2.0|
Neck, Inflammation, Subacute | | 1 4.0|
Neck, Ulcer | | 2 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Dermis, Inflammation, Chronic | | 1 2.0|
Subcutaneous Tissue, Edema | 2 | 17 2.5|
Subcutaneous Tissue, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | 2 2 | 3 2.0|
Hyperkeratosis | | 1 2.0|
Ulcer | | 1 2.0|
Dermis, Inflammation, Chronic | 2 2 | 6 1.8|
Subcutaneous Tissue, Edema | | 8 2.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Thalamus, Mineralization, Focal | 2 1 | 11 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 5| 5| 1| 5| 5| 5| | |
DAY ON TEST | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4| | |
| 9| 6| 5| 5| 2| 2| 1| 8| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Amyloid Deposition, Focal | | 2 2.5|
Congestion | | 5 2.8|
Hemorrhage | | 2 2.5|
Inflammation, Chronic, Focal | 3 2 | 9 2.4|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 4 3 3 | 5 2.8|
Artery, Amyloid Deposition | 3 | 1 3.0|
Interstitium, Inflammation, Chronic | 4 3 3 2 3 | 15 2.3|
Vein, Embolus | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Foreign Body | | 2 2.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 3 |
Ulcer | | 1 4.0|
Bilateral, Ulcer | 4 4 | 2 4.0|
External Ear, Acanthosis | | 1 4.0|
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 4 4 4 2 3 4 4 | 44 3.5|
Hydronephrosis | 2 | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
Nephropathy | | 4 2.0|
Cortex, Atrophy, Focal | 2 2 | 3 2.3|
Cortex, Cyst | X X | 9 |
Cortex, Renal Tubule, Mineralization,| | |
Focal | | 2 2.0|
Pelvis, Dilatation | | 4 2.3|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 5| 4| 5| 4| 5| 5| 1| 5| 5| 5| | |
DAY ON TEST | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4| | |
| 9| 6| 5| 5| 2| 2| 1| 8| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
40 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
LM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 55 |
Amyloid Deposition | | 1 3.0|
Crystals | | 1 2.0|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|
DAY ON TEST | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|
| 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A + + + + + M + + A|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + A + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + A + + + + +|
Edema | 3 3 |
Hemorrhage | |
Polyarteritis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + A + M + A + + + + M|
Amyloid Deposition | 2 2 2 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + A + + + A + + + + +|
Amyloid Deposition | 2 3 2 3 3 3 4 2 3 3 4 3 4 4|
Edema | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + + + A + + + + +|
Amyloid Deposition | 2 1 2 2 2 3 2 2 3 3 3 2 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 2 3 2 2 2 3 2 3 3 3 |
Granuloma | 3 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic, Focal | 2 1 2 2 1 2 2 |
Mitotic Alteration | |
Necrosis, Focal | |
Necrosis | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Polyarteritis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Inflammation, Focal, Suppurative | |
Polyarteritis | |
Acinus, Amyloid Deposition | |
Duct, Cyst | |
Interlobular, Edema | 2 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 3 3 2 2 3 3 2 4 4 3 2|
Inflammation, Focal, Suppurative | |
Interlobular, Edema | 3 2 2 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|
DAY ON TEST | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|
| 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis | 3 |
Aorta, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + M + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2 3 4 3 3 2 3 4 2 2 |
Fibrosis | 4 |
Inflammation, Acute | |
Necrosis, Focal | 2 |
Polyarteritis | 2 |
Atrium, Thrombosis | X X X X |
Pericardium, Inflammation, Focal, | |
Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 1 2 2 2 3 2 1 2 2 2 3 2 2 1 2 2 2|
Corticomedullary Junction, Amyloid | |
Deposition | 3 2 2 2 2 3 1 2 4 2 3 3 2 3 2 |
Corticomedullary Junction, | |
Pigmentation | 3 2 2 2 2 3 3 2 3 2 2 2 2 2 3 2|
Extra Adrenal Tissue, Hemorrhage | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Hypoplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M M M M M + + M + M + + + M + M M + M + M|
Amyloid Deposition | 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M + + + + + + + + M + + I M + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 1 2 2 2 2 3 4 2 |
Inflammation, Chronic | 2 |
C-Cell, Hyperplasia | |
Follicle, Dilatation | 2 2 3 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|
DAY ON TEST | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|
| 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Granuloma Sperm | |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | M |
__________________________________________________________________________|
Prostate | + + + + + + M + + + M + M + + + M + + + + + I + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Granuloma Sperm | 2 |
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Degeneration | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 2 |
Granuloma | |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 2 3 2 4 3 2 3 2 |
Hematopoietic Cell Proliferation | 2 3 3 2 2 2 3 2 2 3 2 3 3 2 2 2 2 2 2|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 2 2 1 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + M + + + I + + M + I M +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Abdominal, Subcutaneous Tissue, Edema| 2 3 2 4 3 3 |
Foot, Ulcer | |
Neck, Subcutaneous Tissue, Hemorrhage| 3 |
Tail, Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|
DAY ON TEST | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|
| 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 2 2 4 3 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Exudate | 2 |
Hyperkeratosis | |
Ulcer | 2 |
Dermis, Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 3 3 1 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Inflammation, Chronic, Focal | 3 1 3 2 2 3 2 2 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 3 3 4|
Artery, Amyloid Deposition | 3 |
Interstitium, Inflammation, Chronic | 3 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
Nasolacrimal Duct, Hemorrhage | 3 |
Nasolacrimal Duct, Hyperplasia | |
Septum, Amyloid Deposition | |
Sinus, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Ulcer | |
Bilateral, Ulcer | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|
DAY ON TEST | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|
| 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 4 3 3 3 4 2 4 3 3 3 4 2 4 4 3 |
Hemorrhage | 3 |
Hydronephrosis | |
Inflammation, Suppurative | |
Nephropathy | 1 |
Cortex, Atrophy, Focal | 3 |
Cortex, Cyst | X X |
Cortex, Renal Tubule, Mineralization,| |
Focal | |
Pelvis, Dilatation | 3 2 2 |
Perirenal Tissue, Hemorrhage | 3 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Hemorrhage | 2 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|
DAY ON TEST | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|
| 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + A + + + + + A + M + + A M + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + A + + + + + A + + + + A + + + + + + A A +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + A + + + + A + + + + + + A A +|
Edema | 3 |
Hemorrhage | |
Polyarteritis | |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + A + M M + + + + + + + + A A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + A + + + + + + + + + + + A A +|
Amyloid Deposition | 3 3|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + A + + + + A + + + + + + A + +|
Amyloid Deposition | 2 1 2 3 4 3 4 4 3 2 3 3 3 4|
Edema | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + A + + + + A + + + + + + A A +|
Amyloid Deposition | 3 2 2 4 2 2 3 3 3|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 3 2 1 1 2 2 2 4 3|
Granuloma | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 2 |
Mitotic Alteration | 3 |
Necrosis, Focal | 2 |
Necrosis | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | |
Polyarteritis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Inflammation, Focal, Suppurative | |
Polyarteritis | |
Acinus, Amyloid Deposition | 2 3|
Duct, Cyst | X |
Interlobular, Edema | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 3 1 4 3 3 2 2 3 3 3 4|
Inflammation, Focal, Suppurative | |
Interlobular, Edema | 2 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|
DAY ON TEST | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|
| 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Polyarteritis | |
Aorta, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 4 3 4 2 3 2 2 2 2 4|
Fibrosis | |
Inflammation, Acute | |
Necrosis, Focal | |
Polyarteritis | |
Atrium, Thrombosis | X X X X X|
Pericardium, Inflammation, Focal, | |
Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 3 2 2 4 2 2 2 2 2 1 2 1 2|
Corticomedullary Junction, Amyloid | |
Deposition | 2 2 2 3 4 1 3 2 2 1 3 3|
Corticomedullary Junction, | |
Pigmentation | 2 3 2 2 3 2 2 2 2 2 2 2 |
Extra Adrenal Tissue, Hemorrhage | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 3 3 |
Hypoplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + M M + + M M + M M + M M M M M|
Amyloid Deposition | 3 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M M + + + + + + + + + + M +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 1 4 4 2 2 2 3|
Inflammation, Chronic | |
C-Cell, Hyperplasia | 1 |
Follicle, Dilatation | 2 2 2 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|
DAY ON TEST | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|
| 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Granuloma Sperm | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + A + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Granuloma Sperm | |
Seminiferous Tubule, Atrophy | 3 4 3 3 |
Seminiferous Tubule, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 3 2 2|
Granuloma | 4 |
Hemorrhage | 4 3 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 4 1 3 2 3 4|
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 2 1 2 3 3 1 3 2 3 3 3 3 2 3 |
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thymus | + M + A + M + + + + + M + + M + + + + M + + + M M|
Depletion Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Abdominal, Subcutaneous Tissue, Edema| 1 2 3 3 3 2 |
Foot, Ulcer | |
Neck, Subcutaneous Tissue, Hemorrhage| |
Tail, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|
DAY ON TEST | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|
| 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 2 3 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Exudate | X |
Hyperkeratosis | 2 |
Ulcer | 4 |
Dermis, Inflammation, Chronic | 1 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + M + + + + + + + + + + + +|
Sternum, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 2 |
Hemorrhage | |
Inflammation, Chronic, Focal | 3 2|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 4 |
Artery, Amyloid Deposition | |
Interstitium, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Hyperplasia | 2 |
Septum, Amyloid Deposition | 2 |
Sinus, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + |
Ulcer | 4 4 |
Bilateral, Ulcer | 4 |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|
DAY ON TEST | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|
| 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
80 MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 3 4 4 4 4 3 3 3 4 3 4 3 4|
Hemorrhage | |
Hydronephrosis | 4 |
Inflammation, Suppurative | 1 |
Nephropathy | 1 2 1 1 1 |
Cortex, Atrophy, Focal | 3 |
Cortex, Cyst | X X X |
Cortex, Renal Tubule, Mineralization,| |
Focal | 1 |
Pelvis, Dilatation | |
Perirenal Tissue, Hemorrhage | |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + A + + + + + + + + +|
Amyloid Deposition | 3 2 |
Hemorrhage | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 3| 5| 5| 4| 5| 4| 4| 5| 5| 5| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
| 2| 2| 2| 4| 4| 8| 4| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | A + + + + + + + + + | 50 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 53 |
Edema | 2 | 4 2.8|
Hemorrhage | 4 | 1 4.0|
Polyarteritis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + | 50 |
Amyloid Deposition | 2 2 2 | 12 1.8|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 53 |
Amyloid Deposition | 3 2 3 3 3 3 2 3 | 36 2.9|
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + | 51 |
Amyloid Deposition | 2 3 2 1 2 3 | 28 2.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 3 1 2 2 | 31 2.3|
Granuloma | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Inflammation, Chronic, Focal | 3 2 | 17 1.9|
Mitotic Alteration | | 1 3.0|
Necrosis, Focal | | 1 2.0|
Necrosis | 2 | 1 2.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Polyarteritis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Focal Cellular Change | X | 2 |
Inflammation, Focal, Suppurative | 2 | 1 2.0|
Polyarteritis | 3 | 1 3.0|
Acinus, Amyloid Deposition | 1 | 3 2.0|
Duct, Cyst | | 1 |
Interlobular, Edema | 3 | 11 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 3 2 3 | 33 2.8|
Inflammation, Focal, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 3| 5| 5| 4| 5| 4| 4| 5| 5| 5| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
| 2| 2| 2| 4| 4| 8| 4| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Interlobular, Edema | 2 | 9 2.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Amyloid Deposition | | 4 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Polyarteritis | | 1 3.0|
Aorta, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 2 3 3 2 2 3 2 | 34 2.6|
Fibrosis | | 1 4.0|
Inflammation, Acute | 2 | 1 2.0|
Necrosis, Focal | 2 | 2 2.0|
Polyarteritis | 2 | 2 2.0|
Atrium, Thrombosis | | 9 |
Pericardium, Inflammation, Focal, | | |
Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
Capsule, Hyperplasia | 2 2 2 1 2 2 2 2 | 40 2.0|
Corticomedullary Junction, Amyloid | | |
Deposition | 2 2 3 2 3 | 32 2.4|
Corticomedullary Junction, | | |
Pigmentation | 2 3 2 2 2 3 2 | 35 2.3|
Extra Adrenal Tissue, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 2 3.0|
Hypoplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M + M M M + | 26 |
Amyloid Deposition | | 6 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + M + + + + + | 50 |
Pars Distalis, Cyst | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + M + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 3| 5| 5| 4| 5| 4| 4| 5| 5| 5| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
| 2| 2| 2| 4| 4| 8| 4| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Amyloid Deposition | 2 2 1 | 24 2.3|
Inflammation, Chronic | | 1 2.0|
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Dilatation | 2 3 | 11 2.2|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Penis | M + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 54 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 2 | 3 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Cyst | | 1 |
Granuloma Sperm | | 1 2.0|
Seminiferous Tubule, Atrophy | 3 2 | 7 2.7|
Seminiferous Tubule, Degeneration | | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Abscess | 4 | 1 4.0|
Amyloid Deposition | | 6 2.2|
Granuloma | | 1 4.0|
Hemorrhage | | 2 3.5|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 3| 5| 5| 4| 5| 4| 4| 5| 5| 5| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
| 2| 2| 2| 4| 4| 8| 4| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Amyloid Deposition | 1 3 3 2 | 23 2.7|
Hematopoietic Cell Proliferation | 3 2 2 2 2 3 2 2 2 | 48 2.3|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 9 1.9|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + | 43 |
Depletion Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | | 1 1.0|
Abdominal, Subcutaneous Tissue, Edema| 3 3 4 2 | 16 2.7|
Foot, Ulcer | 4 | 1 4.0|
Neck, Subcutaneous Tissue, Hemorrhage| | 1 3.0|
Tail, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Edema | 3 1 | 9 2.4|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | 2 | 3 2.3|
Exudate | | 2 2.0|
Hyperkeratosis | | 1 2.0|
Ulcer | 2 | 3 2.7|
Dermis, Inflammation, Chronic | 1 2 | 5 1.6|
Subcutaneous Tissue, Edema | 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Sternum, Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization, Focal | 1 1 2 2 | 16 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 4 2.5|
Hemorrhage | | 1 2.0|
Inflammation, Chronic, Focal | 3 2 | 13 2.4|
Alveolar Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 3| 5| 5| 4| 5| 4| 4| 5| 5| 5| | |
DAY ON TEST | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| | |
| 2| 2| 2| 4| 4| 8| 4| 0| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
80 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 3 | 6 3.3|
Artery, Amyloid Deposition | | 1 3.0|
Interstitium, Inflammation, Chronic | 2 | 6 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 1 2.0|
Fungus | 2 | 1 2.0|
Nasolacrimal Duct, Hemorrhage | | 1 3.0|
Nasolacrimal Duct, Hyperplasia | | 1 2.0|
Septum, Amyloid Deposition | | 1 2.0|
Sinus, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + M + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 4 |
Ulcer | | 2 4.0|
Bilateral, Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 4 3 4 3 4 4 3 | 41 3.4|
Hemorrhage | | 1 3.0|
Hydronephrosis | | 1 4.0|
Inflammation, Suppurative | | 1 1.0|
Nephropathy | | 6 1.2|
Cortex, Atrophy, Focal | | 2 3.0|
Cortex, Cyst | X X | 7 |
Cortex, Renal Tubule, Mineralization,| | |
Focal | | 1 1.0|
Pelvis, Dilatation | 2 | 4 2.3|
Perirenal Tissue, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | + | 3 |
Bulbourethral Gland, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Amyloid Deposition | | 3 2.3|
Hemorrhage | | 1 2.0|
Mucosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|
DAY ON TEST | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|
| 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + M + + + + M A + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + M + + + + + + + + + + + + A + + + + + + + + + +|
Amyloid Deposition | |
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + A + + +|
Amyloid Deposition | |
Edema | |
Polyarteritis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M M + + + + + + A A + + + + A A + + +|
Amyloid Deposition | 2 3 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A A + + + + + + + + +|
Amyloid Deposition | 3 3 3 3 3 3 3 3 3 2 3 4 4 4 2 4 4|
Edema | |
Hemorrhage | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A A + + + + A A + + +|
Amyloid Deposition | 2 3 3 2 3 3 2 2 3 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2 3 2 2 2 2 2 2 2 1 |
Hematopoietic Cell Proliferation | 4 |
Inflammation, Chronic, Focal | 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 3 |
Acinus, Amyloid Deposition | |
Interlobular, Edema | 2 2 3 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 1 3 3 3 2 3 3 2 3 3 1 3 2|
Inflammation, Focal, Suppurative | |
Interlobular, Edema | 3 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Edema | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|
DAY ON TEST | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|
| 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2 2 3 3 3 3 2 3 2 2 3 |
Necrosis, Focal | |
Polyarteritis | |
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 1 2 2 3 2 3 3 3 2 2 3 2|
Corticomedullary Junction, Amyloid | |
Deposition | 2 2 3 3 2 1 2 3 2 2 1 1|
Corticomedullary Junction, | |
Mineralization, Focal | |
Corticomedullary Junction, | |
Pigmentation | 2 1 3 2 3 2 2 2 4 2 2 3 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M + M M M M + + + M + + M + + M + M M + +|
Amyloid Deposition | 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + M + + + + + + + + + + M I + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 4 2 2 2 1|
Inflammation, Chronic | |
C-Cell, Hyperplasia | |
Follicle, Dilatation | 2 2 2 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 2 |
__________________________________________________________________________|
Epididymis | I + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|
DAY ON TEST | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|
| 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granuloma Sperm | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
__________________________________________________________________________|
Prostate | M + + + + M + + + + + + + + + + M I + M + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Dilatation | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | I + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 3 |
Seminiferous Tubule, Degeneration | 2 |
Seminiferous Tubule, Mineralization | |
Tunic, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + I + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 3|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 3 3 3 2 3 1 2 4 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 2 2 3 2 2 3 3 3 2|
Pigmentation, Hemosiderin | 2 2|
__________________________________________________________________________|
Thymus | + M + + + + + M M + + I + M + + + I + M M + M + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Edema | |
Abdominal, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|
DAY ON TEST | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|
| 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abdominal, Subcutaneous Tissue, Edema| 2 3 3 4 3 2 |
Face, Ulcer | |
Head, Ulcer | 4 |
Other, Inflammation, Chronic | |
Other, Ulcer | |
Subcutaneous Tissue, Other, Abscess | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Thalamus, Mineralization, Focal | 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2|
Hemorrhage | 2 3 |
Inflammation, Chronic, Focal | 2 1 2 1 |
Inflammation, Focal, Subacute | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 2 |
Interstitium, Inflammation, Chronic | 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Hemorrhage | 3 |
Inflammation, Suppurative | 4 |
Septum, Amyloid Deposition | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
Ulcer | 4 4 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|
DAY ON TEST | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|
| 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Pinna, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Eye | |
Cataract | |
Lids, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 3 4 3 3 4 2 4 3 4 4 3 2 3 |
Atrophy, Diffuse | 4 |
Infarct | |
Inflammation, Chronic, Focal | 3 |
Inflammation, Suppurative | 4 3 |
Nephropathy | 1 1|
Cortex, Cyst | X X X |
Cortex, Renal Tubule, Mineralization,| |
Focal | 1 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Crystals | |
Inflammation, Suppurative | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|
DAY ON TEST | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|
| 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Gallbladder | + + + + + A + M + + M + + + + A + + + + + A + A +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + A + + + + + A + + +|
Amyloid Deposition | 1 |
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + A + + + + + + + + +|
Amyloid Deposition | 2 |
Edema | 3 |
Polyarteritis | 2 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + M + + + A + + M + + A + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + M + A + + + + + A + + +|
Amyloid Deposition | 2 2 1 1 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + A + + + + + + + + +|
Amyloid Deposition | 3 4 3 1 4 3 4 4 4 3 3 4 4 4 4 3 |
Edema | |
Hemorrhage | |
Necrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + A + + + + + + + + + A + + + + + A + + +|
Amyloid Deposition | 3 3 2 1 2 3 2 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 3 2 2 3 2 2 2 3 2 |
Hematopoietic Cell Proliferation | 4 |
Inflammation, Chronic, Focal | 1 2 2 2 2 2 2 2 1 2 1|
Necrosis, Focal | 2 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
Acinus, Amyloid Deposition | 2 |
Interlobular, Edema | 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 4 2 3 3 3 3 2 |
Inflammation, Focal, Suppurative | 3 |
Interlobular, Edema | 3 1 2 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Edema | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|
DAY ON TEST | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|
| 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 1 2 2 2 1 2 2 4 2 2 |
Necrosis, Focal | 3 |
Polyarteritis | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 3 1 2 2 2 2 2 3 2 2 2 3 2|
Corticomedullary Junction, Amyloid | |
Deposition | 2 3 2 3 2 2 4 2 2 3 2 |
Corticomedullary Junction, | |
Mineralization, Focal | 2 |
Corticomedullary Junction, | |
Pigmentation | 3 3 2 2 4 3 2 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + M M + + M + + M + + M + M M + M|
Amyloid Deposition | 1 2 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M M + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2 3 3 |
Inflammation, Chronic | |
C-Cell, Hyperplasia | 2 |
Follicle, Dilatation | 3 2 3 3 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|
DAY ON TEST | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|
| 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granuloma Sperm | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 4 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + M + M M + + + + + + + +|
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Dilatation | 2 3 3|
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 2 2 3 3 |
Seminiferous Tubule, Degeneration | |
Seminiferous Tubule, Mineralization | |
Tunic, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 2 2 3 2 2 2 |
Hematopoietic Cell Proliferation | 2 3 2 4 3 3 2 3 3 3 2 2 2 2 2 3 2 2 2 3 2 2 2|
Pigmentation, Hemosiderin | 2 2 3 2 2 1 |
__________________________________________________________________________|
Thymus | + + + M + I + + + + M M + + M + I I + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Edema | 1 |
Abdominal, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|
DAY ON TEST | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|
| 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Abdominal, Subcutaneous Tissue, Edema| 3 3 2 3 2 3 3 2 2 |
Face, Ulcer | 4 |
Head, Ulcer | |
Other, Inflammation, Chronic | 2 |
Other, Ulcer | 3 |
Subcutaneous Tissue, Other, Abscess | 4 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Inflammation, Chronic | |
Subcutaneous Tissue, Edema | 3 2 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 1 |
Dermis, Inflammation, Chronic | 2 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1|
Thalamus, Mineralization, Focal | 1 2 1 2 2 2 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 3 |
Hemorrhage | 2 3 |
Inflammation, Chronic, Focal | 3 |
Inflammation, Focal, Subacute | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | 3 2 |
Interstitium, Inflammation, Chronic | 2 3 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | |
Inflammation, Suppurative | |
Septum, Amyloid Deposition | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
_____________________________________________________________________________________________________________________
| 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|
DAY ON TEST | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|
| 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
160 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Pinna, Inflammation, Chronic | |
__________________________________________________________________________|
Eye | + + |
Cataract | 2 |
Lids, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 3 3 3 4 4 3 4 4 4 3 4 4 4 |
Atrophy, Diffuse | |
Infarct | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Suppurative | 4 |
Nephropathy | 1 1 |
Cortex, Cyst | X X |
Cortex, Renal Tubule, Mineralization,| |
Focal | |
Pelvis, Dilatation | 2 2 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Crystals | 3 |
Inflammation, Suppurative | 4 4 |
Mucosa, Hyperplasia | 3 4 |
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| | |
DAY ON TEST | 7| 5| 1| 5| 0| 4| 5| 5| 8| 1| | |
| 1| 2| 7| 2| 7| 1| 4| 4| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Amyloid Deposition | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + M A + + + + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + | 54 |
Amyloid Deposition | | 1 1.0|
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + M + | 54 |
Amyloid Deposition | | 1 2.0|
Edema | | 1 3.0|
Polyarteritis | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + | 53 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 49 |
Amyloid Deposition | 1 1 2 | 12 1.8|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 55 |
Amyloid Deposition | 3 3 4 3 1 3 | 39 3.2|
Edema | 3 | 1 3.0|
Hemorrhage | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 51 |
Amyloid Deposition | 2 1 3 1 3 | 23 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 2 2 2 2 2 | 34 2.1|
Hematopoietic Cell Proliferation | | 2 4.0|
Inflammation, Chronic, Focal | 2 2 2 1 1 | 17 1.7|
Necrosis, Focal | | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Polyarteritis | | 1 3.0|
Acinus, Amyloid Deposition | | 1 2.0|
Interlobular, Edema | 2 2 | 14 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 4 3 3 | 29 2.6|
Inflammation, Focal, Suppurative | | 1 3.0|
Interlobular, Edema | 3 2 2 | 10 2.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
Submucosa, Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| | |
DAY ON TEST | 7| 5| 1| 5| 0| 4| 5| 5| 8| 1| | |
| 1| 2| 7| 2| 7| 1| 4| 4| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 3 2 2 3 | 34 2.2|
Necrosis, Focal | | 1 3.0|
Polyarteritis | | 1 2.0|
Atrium, Thrombosis | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
Capsule, Hyperplasia | 3 3 2 2 2 2 | 39 2.2|
Corticomedullary Junction, Amyloid | | |
Deposition | 1 2 3 2 2 3 3 | 30 2.2|
Corticomedullary Junction, | | |
Mineralization, Focal | | 1 2.0|
Corticomedullary Junction, | | |
Pigmentation | 4 2 2 2 2 | 35 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Focal | 3 | 1 3.0|
Hypertrophy, Focal | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + M M M M | 30 |
Amyloid Deposition | 2 2 | 8 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + I | 52 |
Pars Distalis, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + | 59 |
Amyloid Deposition | 2 2 3 2 | 20 2.2|
Inflammation, Chronic | 1 | 1 1.0|
C-Cell, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| | |
DAY ON TEST | 7| 5| 1| 5| 0| 4| 5| 5| 8| 1| | |
| 1| 2| 7| 2| 7| 1| 4| 4| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Dilatation | 2 2 | 11 2.4|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 2 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + M + M + + + + M I | 47 |
Inflammation, Suppurative | | 3 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Dilatation | | 4 2.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Seminiferous Tubule, Atrophy | 2 3 | 9 2.4|
Seminiferous Tubule, Degeneration | | 1 2.0|
Seminiferous Tubule, Mineralization | 3 | 1 3.0|
Tunic, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hyperplasia | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + | 58 |
Abscess | 3 | 1 3.0|
Amyloid Deposition | 3 1 2 | 6 2.2|
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| | |
DAY ON TEST | 7| 5| 1| 5| 0| 4| 5| 5| 8| 1| | |
| 1| 2| 7| 2| 7| 1| 4| 4| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 4 3 1 3 2 | 28 2.5|
Hematopoietic Cell Proliferation | 2 3 3 2 2 2 2 3 | 50 2.4|
Pigmentation, Hemosiderin | 2 1 2 | 11 1.9|
__________________________________________________________________________|____________|
Thymus | M + + M + + + M + M | 40 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 1.0|
Edema | | 1 1.0|
Abdominal, Inflammation, Chronic | | 1 2.0|
Abdominal, Subcutaneous Tissue, Edema| 4 2 3 | 18 2.7|
Face, Ulcer | | 1 4.0|
Head, Ulcer | | 1 4.0|
Other, Inflammation, Chronic | 4 | 2 3.0|
Other, Ulcer | 4 | 2 3.5|
Subcutaneous Tissue, Other, Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + | 60 |
Dermis, Inflammation, Chronic | 2 2 | 3 2.0|
Subcutaneous Tissue, Edema | 3 3 3 | 6 2.7|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 1.0|
Dermis, Inflammation, Chronic | 3 | 3 2.3|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hydrocephalus | | 1 1.0|
Thalamus, Mineralization, Focal | 2 2 | 13 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| | |
DAY ON TEST | 7| 5| 1| 5| 0| 4| 5| 5| 8| 1| | |
| 1| 2| 7| 2| 7| 1| 4| 4| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 3 | 9 2.2|
Hemorrhage | | 4 2.5|
Inflammation, Chronic, Focal | 2 2 2 | 8 1.9|
Inflammation, Focal, Subacute | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 3 3 2 | 6 2.5|
Interstitium, Inflammation, Chronic | 2 2 2 3 | 12 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 1 4.0|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Septum, Amyloid Deposition | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 4 |
Ulcer | 4 | 3 4.0|
Pinna, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 2.0|
Lids, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 4 3 3 4 3 4 3 | 40 3.4|
Atrophy, Diffuse | | 1 4.0|
Infarct | | 1 3.0|
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Suppurative | | 3 3.7|
Nephropathy | 2 | 5 1.2|
Cortex, Cyst | X X | 7 |
Cortex, Renal Tubule, Mineralization,| | |
Focal | | 1 1.0|
Pelvis, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Urethra | | 2 |
Bulbourethral Gland, Dilatation | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05098-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC P-NITROPHENOL Date: 04/28/97
Route: DERMAL,SOLUTION Time: 07:07:12
__________________________________________________________________________________________________________________________________
| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| | |
DAY ON TEST | 7| 5| 1| 5| 0| 4| 5| 5| 8| 1| | |
| 1| 2| 7| 2| 7| 1| 4| 4| 6| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
160 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MG/KG HM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 2 | 2 2.5|
Crystals | | 1 3.0|
Inflammation, Suppurative | | 2 4.0|
Mucosa, Hyperplasia | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
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---------- END OF REPORT ----------
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