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TDMS Study 05098-01 Pathology Tables

NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12




       Facility:  Hazleton, Maryland

       Chemical CAS #:  100-02-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|             
                                           | 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  A  +  A  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                             4            |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2        2              3              2     2        3  2     2  1|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  3        4  3           4  4     3  4     3  3        3  3     3  3|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  3        4  2              3           2              3  2     2  2|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                   3           3  2     2     2     2        2  2     2  2|             
      Angiectasis, Focal                   | 2                                                                        |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic, Focal         |    2        2  1        1     2  3  1     2           2  1  2            |             
      Necrosis, Focal                      |             2                                                            |             
      Necrosis                             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Acinus, Amyloid Deposition           |                               3                                3         |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
      Interlobular, Edema                  |    3           2     2           2     3           2           3     2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                               3  3     2  3  3              4  3     3  3|             
      Inflammation, Chronic                |                                        2                                 |             
      Interlobular, Edema                  |    3  2        2     2        2        3  2        4        2            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                               3                             3  2         |             
      Necrosis                             |             2                                                            |             
      Epithelium, Vacuolization Cytoplasmic|                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  2     2  2  2           3  2     2  3  2     3        4  3     2  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|             
                                           | 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                           X                 X  X        X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3  2  3  2  2     3  2  2  3  2  2  3  2  3  2     3  2  2  2  2  2  2  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |    4  2     3  4  2           4     1  2     3     3        4  2     2  4|             
      Corticomedullary Junction, Hemorrhage|             2  3                                                         |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2     3  3        4     3  3     4  3        1        2  4     3  3  2  3|             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                4                    2     4                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hypertrophy, Focal                   |                                  2                 2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  M  I  M  +  +  +  +  M  +  +  M  +  M  +  +  +  M|             
      Amyloid Deposition                   |                                        2  3        3           4     2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
      Pars Distalis, Cyst                  |             X                                      X                     |             
      Pars Distalis, Hyperplasia, Focal    |                         1                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3           2           4  3     2  2  3     3        4  3     3  3|             
      Inflammation, Chronic                |                                                                2         |             
      Follicle, Dilatation                 | 2                                      2     3        2  1               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |          3                                                               |             
      Amyloid Deposition                   |    4        2  4              4  4     4  3  4                       4   |             
      Atrophy                              |                                     3              3     3        2  3   |             
      Cyst                                 |                      X                             X                     |             
      Hemorrhage                           |                                                 3                        |             
      Bilateral, Hemorrhage                |    4                                                                     |             
      Periovarian Tissue, Cyst             | X                                            X              X     X     X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                               3                             3            |             
      Congestion                           | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|             
                                           | 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                   1                                                      |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Hypertrophy                  |                            3                                             |             
      Endometrium, Hyperplasia, Cystic     | 3  4  3  3  3  3  4        4  2  2  3  3  4  4     3  4  4     3  4  4  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                                                                          |             
      Sternal, Myelofibrosis               |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2                          4           2  2     4        4  2     2  1|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  3  3  2  4  2  3  2     2  2  2  3  3     2  2  1  2  2  2  2|             
      Hyperplasia, Lymphoid                |                                  4                                       |             
      Pigmentation, Hemosiderin            | 2  3     2        2  2  2     2        2           3           2     3  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  I  M  +  M  M  +  M  +  +  +  +  +  +  M  +  +  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  M  M  +  +  +  +  M  +  M  +  +  +  +  M  +  M  +  +|             
      Hyperplasia                          |       3                                                        3     3   |             
      Hyperplastic Alveolar Nodule         |                   X                                X     X               |             
      Lactation                            |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Subcutaneous Tissue, Edema|    2                 2        2  4     3                       3     2   |             
      Face, Acanthosis                     |                                                                          |             
      Forelimb, Ulcer                      |                                                                          |             
      Other, Inflammation, Chronic         |                                                                          |             
      Thoracic, Acanthosis                 |                                                                          |             
      Thoracic, Ventral, Acanthosis        |                                                                          |             
      Thoracic, Ventral, Exudate           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
      Dermis, Inflammation, Chronic        |                      2                                                   |             
      Subcutaneous Tissue, Edema           |    3                 2                 3  1        2                     |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                           3                              |             
      Hyperkeratosis                       |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|             
                                           | 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                 2                        |             
      Dermis, Inflammation, Chronic        |    2                 2                    2                 2           2|             
      Subcutaneous Tissue, Edema           |                               2                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |                         1           1     1              1           2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                4                                                         |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                  3                                       |             
      Inflammation, Chronic, Focal         |                                           1                    1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                3                                            3           3|             
      Interstitium, Inflammation, Chronic  |             1                                               4            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Bilateral, Ulcer                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    4  4     3  4  3           4  4     4  4  3     4        3  4     4  4|             
      Hypertrophy                          |                         3                                                |             
      Infarct                              |             3                                                            |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                3                                                         |             
      Inflammation, Suppurative            |             4                                                            |             
      Nephropathy                          |                            2        1           3                        |             
      Cortex, Atrophy, Focal               |                                                                          |             
      Pelvis, Dilatation                   |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 5| 3| 4| 5| 4| 5| 5| 5| 5| 5| 4| 4| 4| 1| 5| 5| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 5| 7| 5| 5| 7| 9| 5| 8| 5| 5| 2| 1| 5| 4| 7| 4| 2| 5| 5| 5| 1| 5| 5| 5| 5|             
                                           | 6| 2| 6| 6| 0| 7| 2| 5| 2| 2| 8| 1| 5| 2| 5| 8| 0| 5| 2| 2| 0| 2| 2| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Degeneration, Hyaline           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                   2                                         3           2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|             
                             DAY ON TEST   | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|             
                                           | 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  3  2     2  2              2  1           2  2        1        2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  2  3  2  3  4  4              4  3  2     3  4     3  3  3  3     4   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  3  2     3  3              4              2  2        2        2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3  2  2  2     2  2              2  2        2  2  1  2  2  3        3   |             
      Angiectasis, Focal                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                                                         3|             
      Inflammation, Chronic, Focal         | 2  1     2                    2        2     2           2           2  2|             
      Necrosis, Focal                      |                                                                          |             
      Necrosis                             |                            1                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |       X                                                     X            |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Hypertrophy, Focal           |                2                                                     2   |             
      Interlobular, Edema                  |    3                             3  2           3     3     2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    4  3  2                       3  3  2     2     1  2  3  4  2     2   |             
      Inflammation, Chronic                |                                                                          |             
      Interlobular, Edema                  | 3  4           2                 3  3           3           1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2                                1                                       |             
      Necrosis                             |                                                                          |             
      Epithelium, Vacuolization Cytoplasmic|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  1  2  4     2  2           1  2  2        3  4  2  2  3  2        4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|             
                             DAY ON TEST   | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|             
                                           | 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrium, Thrombosis                   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  3  4  2  3  3  3  3  2  2  2  3  2  2     2  2  2  3  2  3  2  2  2  3|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 4  4  3  2     2  2           1  4  2  2     3  4  4  3  2  2        2   |             
      Corticomedullary Junction, Hemorrhage|                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |       2  4  3  4  2  3  3  2  2        2           2     3  4     2  3  3|             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                         3  3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4                                                                        |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  A  +  +  M  +  M  +  M  +  M  M  +  +  M  M  M  M  +  +  M  +  M  +  M|             
      Amyloid Deposition                   |       2  3                          2                    3           3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                 X                        |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Amyloid Deposition                   |       1  3     2  3              3  2        3           2  1        2   |             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Dilatation                 |                            2        2                                    |             
      Follicular Cell, Hyperplasia         |                               2                    1        3            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |    3              4              4  3        4  3  3  2                  |             
      Atrophy                              |          2              2     2                          2  3            |             
      Cyst                                 |                X                                               X     X   |             
      Hemorrhage                           |                                  3                                       |             
      Bilateral, Hemorrhage                |                                                                          |             
      Periovarian Tissue, Cyst             |                      X     X  X     X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2                                                                     |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|             
                             DAY ON TEST   | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|             
                                           | 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Hypertrophy                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 4  3  4  3  3  3  3  4  4  4  4  4  4  3     3  3  3  3  4  3  4  4  3  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             | 3  3                             2              2                        |             
      Sternal, Myelofibrosis               |                         2  2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Hyperplasia, Plasma Cell             |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                   3                                                      |             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 1  2     2                       2  2        2  4  2  1     2        3   |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  3  2  2  1  2  3  2  2  2  2  3     1  2  2  2  2  3  2  2  2|             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Pigmentation, Hemosiderin            |    2  2              2        2  2              1                 2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  M  +  +  +  +  +  +  +  M  M  +  M  M  M  +  M  M  +  M  +  +  M|             
      Hyperplasia                          |                                                                          |             
      Hyperplastic Alveolar Nodule         |                X                                                         |             
      Lactation                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Subcutaneous Tissue, Edema| 4  3                             3  3        2        3                  |             
      Face, Acanthosis                     |                                                    2                     |             
      Forelimb, Ulcer                      |             4                                                            |             
      Other, Inflammation, Chronic         |                                                                          |             
      Thoracic, Acanthosis                 |                                                    2                     |             
      Thoracic, Ventral, Acanthosis        |             3                                                            |             
      Thoracic, Ventral, Exudate           |             3                                                            |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                     2                                    |             
      Dermis, Inflammation, Chronic        |    2                                                                     |             
      Subcutaneous Tissue, Edema           | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                1                                   2           1         |             
      Hyperkeratosis                       |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|             
                             DAY ON TEST   | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|             
                                           | 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                    2           3         |             
      Dermis, Inflammation, Chronic        |    2  2                          2              2           1            |             
      Subcutaneous Tissue, Edema           |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |       1  1     1                    1     2              1  1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Chronic, Focal         | 2     1           2                          2  3           2     2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                             3            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                          |             
      Interstitium, Inflammation, Chronic  |          2                                         2              2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                          2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
      Bilateral, Ulcer                     |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  4  4  4     4  4        1     4  3  3     3  4  3  4  3  4  2     3   |             
      Hypertrophy                          |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |                      1                                                   |             
      Cortex, Atrophy, Focal               |                                        4                                 |             
      Pelvis, Dilatation                   |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 2| 5| 5| 5| 5| 5| 5| 4| 4| 5| 3| 5| 5| 5| 4| 5| 4| 5| 5| 5| 5|             
                             DAY ON TEST   | 6| 7| 5| 5| 9| 5| 5| 5| 5| 5| 5| 8| 3| 5| 7| 5| 2| 5| 4| 5| 5| 5| 5| 5| 5|             
                                           | 3| 5| 3| 3| 5| 4| 4| 4| 4| 4| 4| 3| 8| 3| 3| 3| 0| 4| 7| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Degeneration, Hyaline           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Amyloid Deposition                   |       3                                                                  |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 5| 5| 5| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1|                                            |            |
                                           | 3| 2| 4| 5| 3| 3| 3| 3| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Edema                                |                   3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   | 2  1     2  1                                                            |     24  1.9|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   | 4  3     3  3     4        2                                             |     37  3.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Amyloid Deposition                   | 2  1     2  1     2                                                      |     25  2.4|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2  2     2  2     1                                                      |     30  2.1|
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                            2                                             |      2  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |    2           1  2  2                                                   |     24  1.8|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Focal Cellular Change                |                                                                          |      2     |
      Acinus, Amyloid Deposition           |                                                                          |      2  3.0|
      Acinus, Hypertrophy, Focal           |                                                                          |      2  2.0|
      Interlobular, Edema                  |                   3                                                      |     15  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2  3     2  2     2                                                      |     27  2.6|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Interlobular, Edema                  |          3        2                                                      |     18  2.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      5  2.2|
      Necrosis                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 5| 5| 5| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1|                                            |            |
                                           | 3| 2| 4| 5| 3| 3| 3| 3| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Vacuolization Cytoplasmic|                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2  2     3  3     4        2                                             |     37  2.5|
      Atrium, Thrombosis                   |                   X                                                      |      6     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Capsule, Hyperplasia                 | 3     3  2  2  2  3  3  2  2                                             |     56  2.4|
      Corticomedullary Junction, Amyloid   |                                                                          |            |
          Deposition                       |    3     2  2  1  2        2                                             |     37  2.6|
      Corticomedullary Junction, Hemorrhage|                                                                          |      2  2.5|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     |          3  4     3  2  2  2                                             |     37  2.8|
      Corticomedullary Junction,           |                                                                          |            |
          Vacuolization Cytoplasmic        |       4                                                                  |      6  3.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Hypertrophy, Focal                   |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  M  M                                             |  34        |
      Amyloid Deposition                   |          2  2                                                            |     12  2.6|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  M                                             |  54        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M                                             |  58        |
      Amyloid Deposition                   |             3                                                            |     23  2.6|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Follicle, Dilatation                 |    2                                                                     |      8  2.0|
      Follicular Cell, Hyperplasia         |    2                                                                     |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 5| 5| 5| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1|                                            |            |
                                           | 3| 2| 4| 5| 3| 3| 3| 3| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Abscess                              |                                                                          |      1  3.0|
      Amyloid Deposition                   |    3        2     2                                                      |     20  3.3|
      Atrophy                              | 3           3     2                                                      |     13  2.5|
      Cyst                                 |          X                                                               |      6     |
      Hemorrhage                           |                                                                          |      2  3.0|
      Bilateral, Hemorrhage                |                                                                          |      1  4.0|
      Periovarian Tissue, Cyst             | X  X  X                    X                                             |     13     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      3  2.7|
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
      Cervix, Cyst                         |                            X                                             |      1     |
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  3  4  3  3  4  3  4  4  4                                             |     55  3.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Calvarium, Myelofibrosis             |                                                                          |      4  2.5|
      Sternal, Myelofibrosis               |                         2                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Amyloid Deposition                   |    2                                                                     |      1  2.0|
      Hyperplasia, Lymphoid                | 3           3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2  3     1  2     2                                                      |     25  2.2|
      Hematopoietic Cell Proliferation     |    3     2  2  2  2  3  2  3                                             |     55  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Pigmentation, Hemosiderin            |                   2  2  2                                                |     22  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  M                                             |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  +  +  +  M  +  M                                             |  38        |
      Hyperplasia                          |                                                                          |      3  3.0|
      Hyperplastic Alveolar Nodule         |                   X                                                      |      5     |
      Lactation                            |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 5| 5| 5| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1|                                            |            |
                                           | 3| 2| 4| 5| 3| 3| 3| 3| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abdominal, Subcutaneous Tissue, Edema| 3  2     3        2        3                                             |     19  2.8|
      Face, Acanthosis                     |                                                                          |      1  2.0|
      Forelimb, Ulcer                      |                                                                          |      1  4.0|
      Other, Inflammation, Chronic         | 2                                                                        |      1  2.0|
      Thoracic, Acanthosis                 |                                                                          |      1  2.0|
      Thoracic, Ventral, Acanthosis        |                                                                          |      1  3.0|
      Thoracic, Ventral, Exudate           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                                                                          |      1  2.0|
      Dermis, Inflammation, Chronic        |    1                                                                     |      3  1.7|
      Subcutaneous Tissue, Edema           |          3                                                               |      8  2.3|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      4  1.8|
      Hyperkeratosis                       |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      3  2.3|
      Dermis, Inflammation, Chronic        |    2                                                                     |     11  1.9|
      Subcutaneous Tissue, Edema           |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thalamus, Mineralization, Focal      |                1     1  1                                                |     15  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |    2        2        2                                                   |     12  1.8|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                      3                                                   |      4  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 5| 5| 5| 5| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 5| 0| 5| 5| 9| 5| 5| 1|                                            |            |
                                           | 3| 2| 4| 5| 3| 3| 3| 3| 3| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VF                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +                                                               |   2        |
      Bilateral, Ulcer                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 4  4     3  3     4        3                                             |     39  3.5|
      Hypertrophy                          |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Nephropathy                          |                         1                                                |      5  1.6|
      Cortex, Atrophy, Focal               |                                                                          |      1  4.0|
      Pelvis, Dilatation                   |    3                                                                     |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Degeneration, Hyaline           |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |          3                                                               |      5  2.6|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|             
                             DAY ON TEST   | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|             
                                           | 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                              1        2                  |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 1           2  3           2        2           2     2     4  2         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  3  4  3  4  4  3  3  2  4  4  1  3     4  2  3  3  4     4  3     3  4|             
      Mucosa, Inflammation, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2     4  3  2  3     2     2        2           2  2  2     2  3     2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  3  2  2  2  2     2     2  2     2     3  1  3  2        2  2     2   |             
      Angiectasis, Focal                   |       2                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic, Focal         | 1        1     1        3     2  2           1     2  2        1         |             
      Necrosis, Focal                      |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                X                                                         |             
      Necrosis, Focal                      |                                                                          |             
      Acinus, Amyloid Deposition           |                                                                2         |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
      Interlobular, Edema                  |                   3                       3           3     2        3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    4  4  3  2  2  3        2        3     3        2        3  4     3   |             
      Interlobular, Edema                  |    3  3           2  4              2     3     3     2     3            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  2  3  3  2  2  2  2     2        3     1     3  3  3     2  4         |             
      Fibrosis                             |                                                                      2   |             
      Inflammation, Acute                  |                         3                                                |             
      Necrosis, Focal                      |                         3                                                |             
      Atrium, Thrombosis                   |                                     X                       X        X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|             
                             DAY ON TEST   | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|             
                                           | 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Hyperplasia                 | 2  3  3  2  3  3  3  2  2  3     2  3  2  3  3  2  2  3  2  2  3  3  2  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 4  4     2  3  3     2     3  2     2     4  2  4  3  4     4  2     3   |             
      Corticomedullary Junction, Hemorrhage|                2                                                         |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2     3           3  4        3     2  3     2     2     2     3  3      |             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |          2              3     2  2                       2              4|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                             4            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  +  +  I  +  +  M  +  M  M  +  M  +  +  M  M  M  +  M  +  M  +|             
      Amyloid Deposition                   |       3        3     2                       2  3           4            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2     2  3  3  3     2                       1  3  2  1     4  3     2   |             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Dilatation                 |                                        2                          2  2   |             
      Follicular Cell, Hyperplasia         |          2                    2     1     2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    4  2  4  4  3  2                          4     3  4                  |             
      Atrophy                              |       3              3                 3        4  3                     |             
      Congestion                           |                                                 3                        |             
      Cyst                                 |       X              X                 X        X           X        X   |             
      Hematocyst                           |                                     X                                    |             
      Hemorrhage                           | 2                 4                                         2            |             
      Periovarian Tissue, Cyst             |          X  X        X           X                       X     X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2                                                                  |             
      Endometrium, Hyperplasia, Cystic     | 4  2  2  4  3  3  3  4  3     3  3  4  4     4  3  3  3  3  3  2  3  3  3|             
      Myometrium, Degeneration             |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                                                                          |             
      Sternal, Myelofibrosis               |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|             
                             DAY ON TEST   | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|             
                                           | 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                           2                              |             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |          3                                                               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  3        2        2     1        2     2           3     3  4     2   |             
      Hematopoietic Cell Proliferation     |       2  2     2  3  2  2  2  3  2  2  2  3  2  2  2  2  1  2  1  2  2  2|             
      Hyperplasia, Lymphoid                |          3                                   3                           |             
      Pigmentation, Hemosiderin            |       2        1     2  2     2     2     2  2  2  2  3     1        2   |             
      Capsule, Hyperplasia, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
      Hyperplastic Alveolar Nodule         |             X                                X                           |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                   2                                         2            |             
      Abdominal, Subcutaneous Tissue, Edema| 2  4  3  3  2     3  4     3              4           2     3        3   |             
      Head, Ulcer                          |                                                                          |             
      Neck, Ulcer                          |                                                                          |             
      Tail, Abscess                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |                                                                          |             
      Subcutaneous Tissue, Edema           |    3  2     3     3        2                    2     3                  |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Dermis, Inflammation, Chronic        |       2                                   2           2     2            |             
      Subcutaneous Tissue, Edema           | 3  3  3           2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |    2        1                    2  2  1        1     1     1            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 5| 4| 5| 4| 4| 3| 4| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 4| 3|             
                             DAY ON TEST   | 5| 9| 5| 5| 7| 5| 4| 9| 6| 8| 5| 5| 3| 5| 9| 5| 5| 5| 2| 5| 9| 5| 5| 4| 6|             
                                           | 2| 7| 6| 2| 7| 2| 9| 2| 7| 2| 2| 2| 0| 4| 7| 4| 4| 4| 7| 4| 7| 4| 4| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                               2                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |       2                                   4        2     1               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                         3                                                |             
      Interstitium, Inflammation, Chronic  |                2        3     3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         3                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  4  4  4  3  3  4  4     4  2     4     4  3  4  4  4     4  4     3   |             
      Infarct                              |                                                                          |             
      Nephropathy                          |                                  1                                1      |             
      Cortex, Atrophy, Focal               |                                                    3                     |             
      Cortex, Cyst                         |                                     X                                    |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|             
                                           | 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
      Amyloid Deposition                   | 2           1        3  2        2     2  2     2  2              3     3|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
      Amyloid Deposition                   | 3  3        3  3     4  4  2  2  2     4  3     4  3        3     3     4|             
      Mucosa, Inflammation, Focal          |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
      Amyloid Deposition                   | 2  2                 3  4        2     2  2     2  2        2     2     3|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  2        3        3  4  2     2     2  2     2  2        2  2  1     2|             
      Angiectasis, Focal                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                          3               |             
      Inflammation, Chronic, Focal         |       2     2  3  3  2        2     2                             1  2   |             
      Necrosis, Focal                      |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Necrosis, Focal                      |                                                                         2|             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Hypertrophy, Focal           |                                                          2               |             
      Interlobular, Edema                  |             3        3  2  3           2        2        1               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3        3  2        4  3     2        3     2  2        3  3  1     3|             
      Interlobular, Edema                  | 2  3        2        3  3              4                 2  3            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  2     2  2  2     2  3  2     3        3     3  2        2  2  2     2|             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Atrium, Thrombosis                   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|             
                                           | 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Hyperplasia                 | 3  3  3     3  3  2  2  3  3  2  2  2  3  3  2  3  3  2           3  2  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 3  3  2  2  4  3     3  3  3     3     3  3     3  2  1     3     3     3|             
      Corticomedullary Junction, Hemorrhage|                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2  2     2        2  2  4     3  3  4  2     3     2  2           2  4   |             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                                       2  4               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  M  M  +  M  M  M  +  A  +  +  +  M  M  +  +  M  M  M  M|             
      Amyloid Deposition                   |    2        3           3                 4     3           3            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  1        3        3                    4     3  3        3  4  2     2|             
      Inflammation, Chronic                |                         3                                                |             
      Follicle, Dilatation                 | 2  2                                         2                           |             
      Follicular Cell, Hyperplasia         | 2                 3                    1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |    4           2     3  3        3        4        3        4           4|             
      Atrophy                              | 2     2     3  2              2     2  3           2                 2   |             
      Congestion                           |                                                                          |             
      Cyst                                 |                   X                          X        X                  |             
      Hematocyst                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Periovarian Tissue, Cyst             |                            X                       X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |                                        3                                 |             
      Endometrium, Hyperplasia, Cystic     | 3  3  4  3  3  3  4  3  3  3  4  4  3  4  3  3  3  3  4  4  3     4  3  2|             
      Myometrium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                         2     2                                          |             
      Sternal, Myelofibrosis               |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|             
                                           | 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Granuloma                            |                                                          4               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                 3                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3  2        3        2  3        3              2     2     2            |             
      Hematopoietic Cell Proliferation     | 2     2     2  3  2  2  3  3  2     2  2  2  2  2  3     4  2     2  2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            | 2     2     1        3  2  2        2  2                       2     2  3|             
      Capsule, Hyperplasia, Focal          |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  I  +  +  +  +  M  +  +  +  +|             
      Depletion Lymphoid                   |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                         2                                                |             
      Hyperplastic Alveolar Nodule         |                                  X                                       |             
      Duct, Hyperplasia                    |                                                          2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                                                          2               |             
      Abdominal, Subcutaneous Tissue, Edema|    2        3        3  3  4           4        3        3  3  3         |             
      Head, Ulcer                          |                   4                                                      |             
      Neck, Ulcer                          |                   4                                                      |             
      Tail, Abscess                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |                                  2     2                                 |             
      Subcutaneous Tissue, Edema           |             3           3        3     3                       2         |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      1                                                   |             
      Dermis, Inflammation, Chronic        |             2        1     2           2                                 |             
      Subcutaneous Tissue, Edema           |                         2  2           3                       3         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |    1        1                    1                             1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 5| 7| 7| 5| 4| 3| 1| 4| 5| 9| 5| 7| 5| 5| 8| 5| 5| 6| 2| 4| 5| 5| 9|             
                                           | 5| 0| 5| 5| 8| 3| 5| 2| 4| 9| 3| 8| 3| 3| 3| 3| 6| 4| 4| 3| 9| 0| 4| 5| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                                3         |             
      Hemorrhage                           |                                                       2        3         |             
      Inflammation, Chronic, Focal         |       2     2        2     2                                             |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                      1                                                   |             
      Interstitium, Inflammation, Chronic  |                                  2                                      2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  A  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  4  1  3  4  4     4  4  4  1  4     4  4     4  4  1  2  3  3  3     3|             
      Infarct                              |                                                                          |             
      Nephropathy                          |                                                                      2   |             
      Cortex, Atrophy, Focal               |                                                                          |             
      Cortex, Cyst                         |                      X                                                   |             
      Pelvis, Dilatation                   |                                  3              3                        |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +|             
      Amyloid Deposition                   |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 2| 5| 5| 5| 4| 5|                                            |            |
                             DAY ON TEST   | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5|                                            |            |
                                           | 5| 2| 0| 7| 6| 2| 0| 5| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  M  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   |    4           2  2                                                      |     23  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |    3     3  3  3  3     3  3                                             |     45  3.2|
      Mucosa, Inflammation, Focal          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  M  +                                             |  54        |
      Amyloid Deposition                   |    1        3  2  2                                                      |     30  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2     2     2  2     2                                                |     37  2.1|
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 2                          1                                             |     21  1.8|
      Necrosis, Focal                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Focal Cellular Change                |                                                                          |      1     |
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Acinus, Amyloid Deposition           |                                                                          |      1  2.0|
      Acinus, Hypertrophy, Focal           |                                                                          |      1  2.0|
      Interlobular, Edema                  |    3           3  3                                                      |     15  2.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |          3        3     2                                                |     29  2.8|
      Interlobular, Edema                  |    3           3  3     3                                                |     21  2.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2              1     2                                                |     35  2.3|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 2| 5| 5| 5| 4| 5|                                            |            |
                             DAY ON TEST   | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5|                                            |            |
                                           | 5| 2| 0| 7| 6| 2| 0| 5| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                X                                                         |      5     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Capsule, Hyperplasia                 | 2  2     2  2  3  2  2  2  2                                             |     54  2.5|
      Corticomedullary Junction, Amyloid   |                                                                          |            |
          Deposition                       |    3     2     2  2     2                                                |     40  2.8|
      Corticomedullary Junction, Hemorrhage|                                                                          |      1  2.0|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     | 2           2  2  3  2  2  2                                             |     34  2.5|
      Corticomedullary Junction,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                            3                                             |      9  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  M  +                                             |  30        |
      Amyloid Deposition                   |    2              2                                                      |     14  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +                                             |  56        |
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   |    2     2                                                               |     26  2.5|
      Inflammation, Chronic                |                            2                                             |      2  2.5|
      Follicle, Dilatation                 |                         2                                                |      7  2.0|
      Follicular Cell, Hyperplasia         | 1                                                                        |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |    4              4     2                                                |     21  3.3|
      Atrophy                              |                                                                          |     14  2.6|
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 | X                                                                        |     10     |
      Hematocyst                           |                   X                                                      |      2     |
      Hemorrhage                           |                                                                          |      3  2.7|
      Periovarian Tissue, Cyst             |                X                                                         |      9     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 2| 5| 5| 5| 4| 5|                                            |            |
                             DAY ON TEST   | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5|                                            |            |
                                           | 5| 2| 0| 7| 6| 2| 0| 5| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   |                                                                          |      2  2.5|
      Endometrium, Hyperplasia, Cystic     | 3  3  2  3  4  4  3  3  3  3                                             |     57  3.2|
      Myometrium, Degeneration             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Calvarium, Myelofibrosis             |                                                                          |      2  2.0|
      Sternal, Myelofibrosis               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |                         2                                                |      2  2.0|
      Granuloma                            |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2     2              2                                                |     23  2.3|
      Hematopoietic Cell Proliferation     | 3  1  2  2  2  2  2  2  2  2                                             |     52  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Pigmentation, Hemosiderin            |          2     3  2                                                      |     27  2.0|
      Capsule, Hyperplasia, Focal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  +  M  M  +  +  +                                             |  49        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  +  M  +  +  +  +                                             |  43        |
      Hyperplasia                          |             1                                                            |      2  1.5|
      Hyperplastic Alveolar Nodule         |                   X                                                      |      4     |
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abdominal, Dermis, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      3  2.0|
      Abdominal, Subcutaneous Tissue, Edema|    3     3     3  3     2                                                |     27  3.0|
      Head, Ulcer                          |                                                                          |      1  4.0|
      Neck, Ulcer                          |                                                                          |      1  4.0|
      Tail, Abscess                        |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dermis, Inflammation, Chronic        |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 2| 5| 5| 5| 4| 5|                                            |            |
                             DAY ON TEST   | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5|                                            |            |
                                           | 5| 2| 0| 7| 6| 2| 0| 5| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Edema           |          2     2        3                                                |     15  2.6|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  1.0|
      Dermis, Inflammation, Chronic        |                2                                                         |      9  1.9|
      Subcutaneous Tissue, Edema           |          3                                                               |      9  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thalamus, Mineralization, Focal      | 1  1  2           1     1                                                |     17  1.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |       2                                                                  |      3  2.3|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         |                            2                                             |      9  2.1|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 2                                                                        |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                                                                          |      2  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  M  M  +  +  +  +  +  +  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    3     4     4  4     4                                                |     45  3.5|
      Infarct                              |             4                                                            |      1  4.0|
      Nephropathy                          |                            1                                             |      4  1.3|
      Cortex, Atrophy, Focal               |                                                                          |      1  3.0|
      Cortex, Cyst                         |                         X                                                |      3     |
      Pelvis, Dilatation                   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                      +                                                   |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 2| 5| 5| 5| 4| 5|                                            |            |
                             DAY ON TEST   | 5| 8| 0| 9| 6| 4| 0| 5| 5| 5|                                            |            |
                                           | 5| 2| 0| 7| 6| 2| 0| 5| 0| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bulbourethral Gland, Dilatation      |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +                                             |  54        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|             
                                           | 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            2     2     2                                 |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  M  +  +  M  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  M  +|             
      Amyloid Deposition                   |    1     2  2              2     1     2              2           1     2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  3  4  3  3  3  2        3  3  4  4  3  4  3     3  4  3  3  4  3  3  3|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +|             
      Amyloid Deposition                   |    1  2  3  2              2     2     1  2           2        3  1     2|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  1  2     2  2  2        2  2  2  2  2     2        2     2  4         |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |       2                                                                  |             
      Inflammation, Chronic, Focal         |                1     2  2                 2  1        2  1     2  2      |             
      Necrosis, Focal                      |                2        2                             2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Polyarteritis                        |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         1|             
      Focal Cellular Change                |                                                                          |             
      Acinus, Amyloid Deposition           |                                                             4            |             
      Acinus, Hypertrophy, Focal           |                                                 2                        |             
      Interlobular, Edema                  | 2        2  3     2                    2     2                 3        3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3  2  3     2              2  2  2  3  3  3  3     3  3     3  3  2      |             
      Inflammation, Focal, Suppurative     |                               3                                          |             
      Interlobular, Edema                  |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                   3                                                      |             
      Mucosa, Degeneration                 |                                                    3                     |             
      Mucosa, Necrosis, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|             
                                           | 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2     2  3  2     2        3  2  2  1  2  2  2     3  2     2  2  2  2  2|             
      Polyarteritis                        |                   3                                                      |             
      Atrium, Thrombosis                   |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3  3     3  2  2  2  2  2  2  2  3  2  2  3  2  1  3  3  3  3  2  2     2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 4        3  2     3        3  2  3  3  2  3  2        3        4     3   |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |    3     2     2  3  2  3  2     1     2  2  2  3  3              2  3  2|             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Focal                   |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  M  M  +  M  M  +  +  +  A  M  +  +  +  M  M  M  M  M  +  M  +|             
      Amyloid Deposition                   | 2  2                       2  2  1        2  2                          2|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Amyloid Deposition                   | 2     2  2                 2  2  3  2  2  2        3           1         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Follicle, Dilatation                 |                2                                                         |             
      Follicular Cell, Hyperplasia         |       2                                   2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4     3  3  2     4        3     4  3     4           4  2  4  4        2|             
      Atrophy                              |    3        3           2  3           3                 3               |             
      Cyst                                 |    X                          X        X     X                           |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|             
                                           | 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Hemorrhage                |                                                                          |             
      Periovarian Tissue, Cyst             |             X  X        X           X           X                    X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |       3                                                                  |             
      Amyloid Deposition                   |                                                                3         |             
      Angiectasis, Focal                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  4  4  3  3  4  4  3  4  3  3  4  1  3  3  3  3  3  4     4  3  4  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
      Sternal, Myelofibrosis               |                                                    2              2     2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             2              2     1                                       |             
      Lymphocyte, Necrosis                 |                               3                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 1                          2  2  1  2     1  3        2     4  4        2|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  1  2  2  2  2  2  2  2  3  2  2  2  2  2  2  3     1     2   |             
      Pigmentation, Hemosiderin            | 2                             2     2        2  2              2     3  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  I  +  +  M  M  M  I  +  I  M|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Hyperplasia                          |                1                                               1         |             
      Hyperplastic Alveolar Nodule         |                                                                          |             
      Inflammation, Chronic                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                                     2                                    |             
      Abdominal, Subcutaneous Tissue, Edema| 3           3                 3     3  3     4                 2     3  3|             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |                                     2                                    |             
      Subcutaneous Tissue, Edema           |                                     4        3              2        3  3|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Focal                       |                                                                          |             
      Dermis, Inflammation, Chronic        |                                                                          |             
      Subcutaneous Tissue, Edema           | 2                                                           2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 4| 5|             
                             DAY ON TEST   | 2| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 6| 5| 5| 5| 0| 3| 4| 5| 7| 0|             
                                           | 1| 6| 6| 6| 0| 6| 4| 4| 4| 4| 8| 4| 8| 3| 3| 3| 3| 3| 2| 7| 8| 6| 2| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                2         |             
      Thalamus, Mineralization, Focal      | 1                                         1  1                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                                    |             
      Inflammation, Chronic, Focal         |    3                                2     1           2     3  3         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                3         |             
      Artery, Amyloid Deposition           |    3                                                                     |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia, Focal           |                2                                                         |             
      Septum, Amyloid Deposition           |                                           2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  1  3  4  4  1  4        4  4  4  4  4  3  4        3  3  3  4  3  3  4|             
      Hydronephrosis                       |          3                                                               |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                         1                                                |             
      Capsule, Inflammation, Focal         |                                                                          |             
      Cortex, Atrophy, Focal               |             2                                                            |             
      Cortex, Atrophy                      |                                                                      3   |             
      Cortex, Cyst                         |       X                                                                  |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +  +  M  +|             
      Amyloid Deposition                   |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|             
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3                                                               |             
      Edema                                |                   3           4                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2                 2                                      2           2  2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4                 2  4  3              2        2     3  3  3     3  3  3|             
      Edema                                |                   2           4                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2                 2                                      2        2  2  2|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        2        2  3                 2              2  2        2  2  2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Chronic, Focal         |    2        2  3     1        1  1  1           1        1     2         |             
      Necrosis, Focal                      |                                           3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Focal Cellular Change                |                                                          X               |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Hypertrophy, Focal           |             2              2           2                                 |             
      Interlobular, Edema                  | 2                    2                          2           2           2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        2        2  4                 3  2     2     2  2           2  3|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Interlobular, Edema                  |                   3  3        3                       2           4      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Mucosa, Degeneration                 |                                        3                                 |             
      Mucosa, Necrosis, Focal              |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|             
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3        3        1  2                 2        2     3  2  2     1  3  3|             
      Polyarteritis                        |                         3                                                |             
      Atrium, Thrombosis                   | X                                                                       X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  3  2  3  2  3  2  3  2  2  2  3  2  3  2  2  2  2  2  2  2  3  3  3  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 3        3        2  3        2        3  2     3     2  3  2     3  3   |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2  4  2  1  3     2  2  3  3        3              2  3        2  2     4|             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                                              4                 3         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  +  M  M  M  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  M|             
      Amyloid Deposition                   | 3                                               2                 2  2   |             
      Cyst                                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Necrosis                             |                                                 4                        |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia, Focal    |    1                       3                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        2        1  3                          2        2        2  2   |             
      Inflammation, Acute                  |                                           2                              |             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Dilatation                 |       2                       3        2                             2   |             
      Follicular Cell, Hyperplasia         | 3     1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4        3        3  4                 3        3     2  2        2  4  2|             
      Atrophy                              |       2     3  3  3                    3              3  2  2            |             
      Cyst                                 |          X     X                    X           X                        |             
      Hemorrhage                           |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|             
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Hemorrhage                |                                                 4                        |             
      Periovarian Tissue, Cyst             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Angiectasis, Focal                   |             3                                                            |             
      Hemorrhage                           |                                                                4         |             
      Endometrium, Hyperplasia, Cystic     |    4  3  3  3  3  3  3  3  3  3  3  4  3  3  3  3  4  3  3  3  3  3  4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Myelofibrosis               |       3                                            2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Lymphocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        2        2  3                 2        2     3  2        2  1   |             
      Hematopoietic Cell Proliferation     | 3  3  2  2  3  3  2  2  2  2  2  2  2  2  4  2  2  2     2  4  1  2  2  3|             
      Pigmentation, Hemosiderin            |                   2  2                                         2  2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +  +  +  +  +|             
      Amyloid Deposition                   |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplastic Alveolar Nodule         |                            X                                             |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      1                                                   |             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Abdominal, Subcutaneous Tissue, Edema| 3                 3  3        4                       3           3      |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |                                                                2         |             
      Subcutaneous Tissue, Edema           |                      3        3                 3                 3     2|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Focal                       |          1                                                               |             
      Dermis, Inflammation, Chronic        |                      2                                                   |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 5| 4| 4| 5| 5| 5| 5| 5| 5| 4| 3| 4| 5| 5| 5| 5| 4| 4| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 3| 5| 5| 7| 4| 5| 5| 0| 5| 5| 4| 4| 4| 7| 5| 3| 5| 0| 0| 6| 5| 4|             
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 4| 2| 2| 8| 2| 9| 7| 3| 2| 3| 7| 1| 4| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Thalamus, Mineralization, Focal      |       1                                            1           1         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3                       3                           |             
      Inflammation, Chronic, Focal         |          3  3                          2  2              2        2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                         3|             
      Artery, Amyloid Deposition           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia, Focal           |                                                                          |             
      Septum, Amyloid Deposition           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4        3        4  4  3     3        3  2     4     4  3  2     4  3  4|             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                                                                1         |             
      Capsule, Inflammation, Focal         |                                                                          |             
      Cortex, Atrophy, Focal               |                                                                          |             
      Cortex, Atrophy                      |                                                                          |             
      Cortex, Cyst                         |                                     X                                    |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
           Focal                           |                                                                2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 5| 7| 6| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Cyst                                 |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Edema                                |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +                                             |  54        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |    2              1                                                      |     16  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    3  3  3     3  3     3  3                                             |     41  3.1|
      Edema                                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   |    2              1                                                      |     20  1.9|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2  2                                                                  |     27  2.1|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |    3     2        2  1  2                                                |     24  1.7|
      Necrosis, Focal                      |          2     3                                                         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Polyarteritis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  1.0|
      Focal Cellular Change                |                                                                          |      1     |
      Acinus, Amyloid Deposition           |                                                                          |      1  4.0|
      Acinus, Hypertrophy, Focal           |    2           2                                                         |      6  2.0|
      Interlobular, Edema                  |    3                                                                     |     14  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |       3        1  2     1  2                                             |     32  2.4|
      Inflammation, Focal, Suppurative     |                                                                          |      1  3.0|
      Interlobular, Edema                  |    2                    2                                                |      8  2.6|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 5| 7| 6| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Mucosa, Degeneration                 |                                                                          |      2  3.0|
      Mucosa, Necrosis, Focal              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |       2           3                                                      |     33  2.2|
      Polyarteritis                        |          2                                                               |      3  2.7|
      Atrium, Thrombosis                   |                                                                          |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Capsule, Hyperplasia                 | 2  2  2  2  2  1  2  2  2  3                                             |     58  2.3|
      Corticomedullary Junction, Amyloid   |                                                                          |            |
          Deposition                       |    2  4              2  2                                                |     32  2.7|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     |    4     2  3  2  3     2  2                                             |     38  2.4|
      Corticomedullary Junction,           |                                                                          |            |
          Vacuolization Cytoplasmic        |                      3  2                                                |      5  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  M  +  +  M  M                                             |  30        |
      Amyloid Deposition                   |    3  2           2                                                      |     15  2.1|
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +                                             |  54        |
      Necrosis                             |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |                         X                                                |      2     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +                                             |  56        |
      Amyloid Deposition                   |    3  1           2                                                      |     22  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Follicle, Dilatation                 |                      2                                                   |      6  2.2|
      Follicular Cell, Hyperplasia         |                      2                                                   |      5  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 5| 7| 6| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |       3           1                                                      |     27  3.0|
      Atrophy                              |       3     2                                                            |     16  2.7|
      Cyst                                 |    X                                                                     |      9     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Bilateral, Hemorrhage                |                                                                          |      1  4.0|
      Periovarian Tissue, Cyst             |                         X                                                |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     | 3  3  3  4  2  3  4  4  4  3                                             |     58  3.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Sternal, Myelofibrosis               |    2  2                                                                  |      7  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      3  1.7|
      Lymphocyte, Necrosis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                   2                                                      |     22  2.1|
      Hematopoietic Cell Proliferation     | 3  2  2  3  2  2  2  2  2  2                                             |     56  2.2|
      Pigmentation, Hemosiderin            |       2     1           2  2                                             |     17  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  M  +  +  M  +  +                                             |  42        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  M                                             |  44        |
      Hyperplasia                          |                                                                          |      2  1.0|
      Hyperplastic Alveolar Nodule         |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 5| 7| 6| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  1.0|
      Abdominal, Dermis, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Abdominal, Subcutaneous Tissue, Edema|    3  3                                                                  |     17  3.1|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dermis, Inflammation, Chronic        |    1                                                                     |      3  1.7|
      Subcutaneous Tissue, Edema           |    2  3                                                                  |     12  2.8|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate, Focal                       |                                                                          |      1  1.0|
      Dermis, Inflammation, Chronic        |    1                                                                     |      2  1.5|
      Subcutaneous Tissue, Edema           |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Thalamus, Mineralization, Focal      |          1  1              1                                             |      9  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |       2                                                                  |      4  2.5|
      Inflammation, Chronic, Focal         | 2                    2                                                   |     14  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                                                                          |      2  3.0|
      Artery, Amyloid Deposition           |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Glands, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Septum, Amyloid Deposition           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 4| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 2| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 5| 7| 6| 5| 5| 5| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    3  4  1     1  3        2                                             |     42  3.2|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |    2                                                                     |      1  2.0|
      Nephropathy                          |                                                                          |      2  1.0|
      Capsule, Inflammation, Focal         |          3                                                               |      1  3.0|
      Cortex, Atrophy, Focal               |                                                                          |      1  2.0|
      Cortex, Atrophy                      |                                                                          |      1  3.0|
      Cortex, Cyst                         |                                                                          |      2     |
      Cortex, Renal Tubule, Mineralization,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|             
                             DAY ON TEST   | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|             
                                           | 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2     3  2  1  2                             2  2     2           2|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2     3  3  3  4  4     3  4  4        3  4  4  4  3     3     3  4  4|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Amyloid Deposition                   |    2  1  1  3  2  1  3     3  2  2           4  2  2  3     2     2  4   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    1     2  2  2     2     3  3  2           2  2  3  2     2     2  2  2|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic, Focal         | 1           2           1  1     2        2              2  2           2|             
      Necrosis, Focal                      |          2                                                               |             
      Necrosis                             |                                     4                                    |             
      Centrilobular, Hypertrophy           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Hemorrhage, Focal                    |                            3                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                X                                                         |             
      Polyarteritis                        |                                                                          |             
      Acinus, Hypertrophy, Focal           |                                           2                              |             
      Interlobular, Edema                  |                2  3                          2     2              3  3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2  3  3  3     3     3  4              3  3     2     3     3  3  3|             
      Inflammation, Chronic                |                                                 2                        |             
      Interlobular, Edema                  |          3     3  3                                               2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Submucosa, Inflammation, Subacute    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            2                 2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|             
                             DAY ON TEST   | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|             
                                           | 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2  2  1  2  1  2     3  2  3           3  3  3  2     3     3  3  2|             
      Polyarteritis                        |                                                                          |             
      Atrium, Inflammation, Suppurative    |                                              4                           |             
      Atrium, Thrombosis                   |                                              X                           |             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Suppurative                     |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3  3  2     3  2  3  2  2  2  2  2     3  2  3  2  2  2  2  3  3  3  2  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |    1  2     2  2  2  3     4  2              3  2  4        3     3  2  4|             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2  3           2  3     2        4     2        3  2  4  2  3  3     3  2|             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |             3                             3                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4                                                                     |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  +  +  M  +  +  +  M  A  +  +  +  M  M  +  M  M  +  +  M  M|             
      Amyloid Deposition                   |                            2                 2        2           2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2     2              2                 2  3  3        3     3     3|             
      Inflammation, Chronic                |       2                                                                  |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 | 2  3     3              2     3                       2                  |             
      Follicular Cell, Hyperplasia         |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
      Granuloma                            |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |    3  4  3  4  4     2     3     2        3  4  4  4        3     4     3|             
      Atrophy                              | 3        4  3                                   4                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|             
                             DAY ON TEST   | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|             
                                           | 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |             X        X           X              X                 X  X   |             
      Hematocyst                           |                                                                          |             
      Hemorrhage                           |                3              3                                         3|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                X        X     X        X  X        X     X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Cervix, Hypertrophy                  |                                                                          |             
      Cervix, Inflammation, Subacute       |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  4  3  4  4  3  3  3  4  3  3  3     3  3  3  3  3  4  4  3  3  4  4  2|             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                                                 3                        |             
      Sternal, Myelofibrosis               |                                                                1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |       3                                                                  |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2                 2                                                   |             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                       4           3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3           2     2  2              2  2  4        1     2  2  2|             
      Hematopoietic Cell Proliferation     | 3  2  3  1  2  2  4  2  2  2  3  2  2     2  3  3  1  2  3  3  2  2  2  2|             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Pigmentation, Hemosiderin            |          3     2           2                       3                    2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M  M  +  +  M  +  +  M  M|             
      Hyperplasia                          |                                                       3                  |             
      Hyperplastic Alveolar Nodule         |                X                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Abdominal, Subcutaneous Tissue, Edema|          2     2           3  2                    4        2     3  2  2|             
      Neck, Ulcer                          |    4                                                                     |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|             
                             DAY ON TEST   | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|             
                                           | 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Edema           |          2        1        3                                            3|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                 2                        |             
      Dermis, Inflammation, Chronic        |       1                    2                    2                       2|             
      Subcutaneous Tissue, Edema           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |          1           1     1                       2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                           2                              |             
      Inflammation, Chronic, Focal         |          2        2                                                      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                 4                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                              3  4                       3|             
      Interstitium, Inflammation, Chronic  |                                              3                          3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    4                                                                     |             
      Amyloid Deposition                   |    4  3  3  4  4  3  3     4  4  2           4  4  4  3     4     3  4  4|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          |                         1                                2               |             
      Cortex, Atrophy, Focal               |                                                                          |             
      Cortex, Cyst                         |                               X                                          |             
      Pelvis, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 4| 4| 5| 5| 4| 5| 5| 5| 4| 5| 0| 5| 3| 4| 5| 5| 5| 5| 5| 5| 4| 5| 4|             
                             DAY ON TEST   | 5| 7| 8| 7| 5| 4| 6| 5| 5| 0| 7| 5| 8| 5| 7| 9| 5| 4| 5| 5| 3| 5| 4| 2| 8|             
                                           | 5| 5| 6| 5| 5| 6| 3| 5| 5| 9| 3| 5| 4| 6| 1| 2| 6| 2| 6| 6| 2| 6| 3| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|             
                                           | 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Amyloid Deposition                   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                         4                                                |             
      Polyarteritis                        |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Amyloid Deposition                   |          2        1        2  1        1     2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3     3  2     4  4     4  3     4  3     4  4     4              3  4|             
      Hyperplasia, Lymphoid                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3        3  4        2     3        2                       1  3|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        1        2     2  2  2     2  2     2  2     3                 2|             
      Clear Cell Focus                     |                                                    X                     |             
      Hematopoietic Cell Proliferation     |             3                                                            |             
      Inflammation, Chronic, Focal         |    1  2              2     2              2        2  1        2     2   |             
      Necrosis, Focal                      |                      2                                                   |             
      Necrosis                             |                                                                          |             
      Centrilobular, Hypertrophy           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                             X            |             
      Polyarteritis                        |                                                       2                  |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
      Interlobular, Edema                  |          3              3  3  2     2        2  2                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4  2     3        3  2  3     4     3  2     3  3     3              1   |             
      Inflammation, Chronic                |                                                                          |             
      Interlobular, Edema                  |          3                 3                 2  3                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                      2                                                   |             
      Submucosa, Inflammation, Subacute    |                      3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|             
                                           | 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  1     1        2  1  3           2        2                       1  1|             
      Polyarteritis                        |                                                       2                  |             
      Atrium, Inflammation, Suppurative    |                                                                          |             
      Atrium, Thrombosis                   |                         X                                               X|             
      Myocardium, Inflammation, Focal,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    3  3  2  2  2  2  3  3  2  2  2  3  3  3  3  3  3  3  3  2  2  2  2   |             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |    3     2        3  3  3  3  2     4  2     3  3     4              2  3|             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |    3        3  2              2  3              2  3  1  3  4  2  2  2   |             
      Corticomedullary Junction,           |                                                                          |             
          Vacuolization Cytoplasmic        |                3                                                     3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  +  +  +  M  M  M  +  M  M  M  +  M  M  M  +  +  M  M  +  M  M|             
      Amyloid Deposition                   |                   2           2                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Amyloid Deposition                   | 3                 2     2           2                 1                  |             
      Inflammation, Chronic                |                                                                          |             
      C-Cell, Hyperplasia                  |                      1                                                   |             
      Follicle, Dilatation                 |                2                    3                             2      |             
      Follicular Cell, Hyperplasia         |    2           1                    1  1        1              3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Granuloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                4         |             
      Amyloid Deposition                   | 4  4     4        4  2  4  2  3              3  2                    4   |             
      Atrophy                              |                2                    3                       3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|             
                                           | 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                         X        X              X     X  X     X         |             
      Hematocyst                           |                   X                                                      |             
      Hemorrhage                           |                                                                          |             
      Follicle, Cyst                       |                                                    X                     |             
      Periovarian Tissue, Cyst             |          X     X  X                       X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |             4                                                            |             
      Amyloid Deposition                   |    3                                                                     |             
      Cervix, Hypertrophy                  |                   3                                                      |             
      Cervix, Inflammation, Subacute       |                   3                                                      |             
      Endometrium, Hyperplasia, Cystic     | 3  4     3  4  3  3     4  2  3  4  4  4  4  3  3  4  4  3  3  3  4  4  4|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                                                                          |             
      Sternal, Myelofibrosis               |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia                   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Necrosis                             |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             2                                                            |             
      Granuloma                            |                                           4                              |             
      Hyperplasia, Lymphoid                |                                     2                                3   |             
      Hyperplasia                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            3  2              2  2     2                  |             
      Hematopoietic Cell Proliferation     | 1  2     2  3  2  2  3  3  2     2  2  2  3  2     2  3  3  3  4  2  3  1|             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Pigmentation, Hemosiderin            |                2  2     2     3  2        2     1  2  2  2  2     2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  I  M  M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +  M  M  M  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
      Hyperplastic Alveolar Nodule         |             X     X                                               X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                                              2                           |             
      Abdominal, Subcutaneous Tissue, Edema|          3        2     3  3  2     3        3  2                        |             
      Neck, Ulcer                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|             
                                           | 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                               1                                          |             
      Subcutaneous Tissue, Edema           |                            2                    2                       3|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                2         |             
      Hyperkeratosis                       |                                                                2         |             
      Ulcer                                |                                                                          |             
      Dermis, Inflammation, Chronic        |                            2                                   2         |             
      Subcutaneous Tissue, Edema           |                            2        2           2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |       1     1           1     2     2           1                       1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 1                                                                        |             
      Hemorrhage                           |                                                          2           3   |             
      Inflammation, Chronic, Focal         |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |             3                                   1                        |             
      Interstitium, Inflammation, Chronic  |             4                                                  2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Anterior Chamber, Hemorrhage         |                            3                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +              +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   | 4  3     4  2     4  2  4  4  4     4  3     4  4     4              3  4|             
      Hydronephrosis                       |                                     4                                    |             
      Nephropathy                          |                                  2                 2                     |             
      Cortex, Atrophy, Focal               |             2                                                            |             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Dilatation                   |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 5| 4| 4| 5| 4| 4| 5| 4| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5|             
                             DAY ON TEST   | 1| 5| 5| 0| 5| 5| 5| 7| 3| 6| 5| 5| 9| 5| 5| 2| 0| 5| 7| 1| 5| 5| 5| 5| 3|             
                                           | 1| 2| 2| 7| 2| 4| 8| 5| 1| 8| 4| 6| 7| 6| 6| 4| 0| 5| 0| 7| 5| 5| 5| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0|                                            |            |
                                           | 6| 8| 6| 1| 2| 2| 2| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  M  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  A  +                                             |  56        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  A  +                                             |  53        |
      Amyloid Deposition                   |    2     3     2                                                         |     19  1.9|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  A  +                                             |  56        |
      Amyloid Deposition                   | 3  3  3  4     4           4                                             |     38  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  A  +                                             |  55        |
      Amyloid Deposition                   |    1     3     4                                                         |     28  2.4|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    3     2     2        2  2                                             |     33  2.1|
      Clear Cell Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 2     1     1  2  1  1                                                   |     24  1.6|
      Necrosis, Focal                      | 2                                                                        |      3  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Centrilobular, Hypertrophy           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Focal Cellular Change                |    X                                                                     |      3     |
      Polyarteritis                        |                                                                          |      1  2.0|
      Acinus, Hypertrophy, Focal           |                                                                          |      1  2.0|
      Interlobular, Edema                  |          2                 2                                             |     15  2.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2  3     2     3           3                                             |     32  2.8|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Interlobular, Edema                  |          3              2  3                                             |     11  2.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0|                                            |            |
                                           | 6| 8| 6| 1| 2| 2| 2| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |                                                                          |      1  2.0|
      Submucosa, Inflammation, Subacute    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    1                                                                     |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2     2              1                                                |     31  2.0|
      Polyarteritis                        |                                                                          |      1  2.0|
      Atrium, Inflammation, Suppurative    |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                                                                          |      3     |
      Myocardium, Inflammation, Focal,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Capsule, Hyperplasia                 | 2  3  3  2  2  2  3  2  2                                                |     55  2.4|
      Corticomedullary Junction, Amyloid   |                                                                          |            |
          Deposition                       |    3           2        3  3                                             |     33  2.7|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     | 2     4  4  2     4                                                      |     33  2.7|
      Corticomedullary Junction,           |                                                                          |            |
          Vacuolization Cytoplasmic        | 3           2                                                            |      6  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hypertrophy, Focal                   |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  M  +  M  +  M                                             |  25        |
      Amyloid Deposition                   |    3     2                                                               |      8  2.1|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Pars Distalis, Cyst                  |                            X                                             |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |    3           1        2                                                |     17  2.3|
      Inflammation, Chronic                |                1                                                         |      2  1.5|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicle, Dilatation                 |          2                                                               |     10  2.4|
      Follicular Cell, Hyperplasia         |             2              2                                             |      9  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0|                                            |            |
                                           | 6| 8| 6| 1| 2| 2| 2| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Granuloma                            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   | 3  3           4        4  3                                             |     31  3.3|
      Atrophy                              |    3  3                    3                                             |     10  3.1|
      Cyst                                 |                   X                                                      |     13     |
      Hematocyst                           |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      3  3.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Cyst             | X                                                                        |     12     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Cervix, Inflammation, Subacute       |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 3  3  4  3  3  4  3  3  3  3                                             |     58  3.4|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Calvarium, Myelofibrosis             |                                                                          |      1  3.0|
      Sternal, Myelofibrosis               |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +                                             |  58        |
      Amyloid Deposition                   |                                                                          |      3  2.0|
      Granuloma                            |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |    3                                                                     |      3  2.7|
      Hyperplasia                          |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2     2              3                                                |     19  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0|                                            |            |
                                           | 6| 8| 6| 1| 2| 2| 2| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  3  2  2  1  2                                             |     56  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Pigmentation, Hemosiderin            |    2  2  3           2  2  2                                             |     24  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  I                                             |  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  M                                             |  42        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Hyperplastic Alveolar Nodule         |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abdominal, Dermis, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Abdominal, Subcutaneous Tissue, Edema|    2     3                 3                                             |     21  2.5|
      Neck, Ulcer                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Subcutaneous Tissue, Edema           |                         2  3                                             |      9  2.3|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Dermis, Inflammation, Chronic        |                            2                                             |      7  1.9|
      Subcutaneous Tissue, Edema           |                         2  3                                             |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thalamus, Mineralization, Focal      |          1     2                                                         |     13  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                      3                                                   |      2  2.0|
      Hemorrhage                           |                                                                          |      3  2.3|
      Inflammation, Chronic, Focal         |                2                                                         |      4  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 5| 5| 4|                                            |            |
                             DAY ON TEST   | 5| 0| 5| 3| 5| 5| 5| 0| 4| 0|                                            |            |
                                           | 6| 8| 6| 1| 2| 2| 2| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE FEMALE               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    MG/KG HF                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal, Histiocyte               | 2                                                                        |      6  2.7|
      Interstitium, Inflammation, Chronic  | 2           2           2                                                |      7  2.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Anterior Chamber, Hemorrhage         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  4.0|
      Amyloid Deposition                   | 2  4  2  4     3        4  4                                             |     41  3.5|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Nephropathy                          |             1                                                            |      5  1.6|
      Cortex, Atrophy, Focal               |                                                                          |      1  2.0|
      Cortex, Cyst                         |                                                                          |      1     |
      Pelvis, Dilatation                   |                   1     3                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|             
                             DAY ON TEST   | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|             
                                           | 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  M  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  A  A  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Abscess                      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |       2  4  2     2  3              4        2              3  4         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |    3  3  4  3     3  3     3        4        2  3  2        3  4  4  3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |    3  2  3        2  3     2        2        2  3           3  4  4      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2  3  2  2  2  2     3        3           2        2  1  3     2   |             
      Degeneration, Fatty                  |                                                                          |             
      Inflammation, Chronic, Focal         |       1     2           2     1        2           1     2     2         |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Focal                      |                                                             3            |             
      Centrilobular, Hypertrophy           |                                              2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Granuloma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                X                                                         |             
      Acinus, Amyloid Deposition           |          3                                                               |             
      Acinus, Hypertrophy, Focal           |             2                                                            |             
      Interlobular, Edema                  |                2     2     2        3                    3     3  2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3        3        4     3        4        3  2  2              2  2   |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Interlobular, Edema                  |                4     2                       2                 3     3   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|             
                             DAY ON TEST   | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|             
                                           | 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
      Aorta, Thrombosis                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2     3  3  1  2     4        4        4     1        2  3     2   |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Atrium, Thrombosis                   |    X     X     X           X        X                          X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    3  3  1  2  1  2  3     2     2     2  2  3     2           3     2   |             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |    2  3  4  2  3     4     2        3        3  3        3  1  4     2   |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |    3  2     3  3  2        3  2  2  3  2     3     3        2           2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          3                                                               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  M  M  M  M  M  +  M  +  M  M  +  M  M  +  +  M  M  +  M  M  +|             
      Amyloid Deposition                   |          4                 4                                   3         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia, Focal    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       1  3  2  3  2  1     4        3           1        3     3     3   |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 |          3  1                    3           3  3     2           3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                      +   |             
      Dilatation                           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Fat, Necrosis                        |                                        2                                 |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|             
                             DAY ON TEST   | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|             
                                           | 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Dilatation                           |          4                 2     2                       3               |             
      Hemorrhage                           |    3                                                                     |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                               3                                          |             
      Seminiferous Tubule, Atrophy         |          4                                                               |             
      Seminiferous Tubule, Degeneration    |             3                 3                    2                     |             
      Seminiferous Tubule, Mineralization  |                                              3                           |             
      Seminiferous Tubule, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Amyloid Deposition                   |                                                 2                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2  4     4  3  4     4        3        1  3        2     4     4   |             
      Hematopoietic Cell Proliferation     | 2  2  2     2  3        2     2  2  2  2  3  2     2     2  3  1  2  2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                     2              2                 2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  I  +  A  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  M  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  +  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Abdominal, Edema                     |                                                    2                     |             
      Abdominal, Subcutaneous Tissue, Edema|                            2        2        2        1  2  3  2     3   |             
      Neck, Ulcer                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |    2           2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|             
                             DAY ON TEST   | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|             
                                           | 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Edema           |                2     2              2                          2     2   |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             2                                                            |             
      Hyperkeratosis                       |             2                                                            |             
      Subcutaneous Tissue, Edema           |                                     2                    3           2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |       1           1     1     1     1  1                       2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3           2|             
      Foreign Body                         |                                                 2                        |             
      Hemorrhage                           |                                           3                              |             
      Inflammation, Chronic, Focal         |    3     3                 3                                   2         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    3  2                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |          3                          3                                    |             
      Artery, Amyloid Deposition           |                3                                         3     2         |             
      Interstitium, Inflammation, Chronic  |                                     3                    2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
      Foreign Body                         |                                                 4                        |             
      Fungus                               |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Cataract                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  4  4  4  4  3  4  1  4        4        4  4  1     4  2  4  2  4   |             
      Nephropathy                          |                               2        2                          2      |             
      Cortex, Atrophy, Focal               |                   3                                                      |             
      Cortex, Cyst                         |                                                                          |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 4| 4| 4| 5| 5| 4| 3| 4| 3| 4| 5|             
                             DAY ON TEST   | 2| 4| 5| 1| 5| 8| 5| 3| 5| 3| 5| 5| 2| 5| 2| 9| 1| 5| 5| 8| 9| 8| 5| 1| 5|             
                                           | 6| 9| 2| 0| 2| 5| 4| 0| 4| 6| 4| 4| 1| 3| 0| 3| 2| 3| 3| 6| 7| 6| 4| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Focal                           |                2                             2                          2|             
      Pelvis, Dilatation                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|             
                                           | 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          2                                                               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic                |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       2                  |             
      Hyperplasia, Lymphoid                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Abscess                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3     1  1  1        2     2        1  1           2  2        2  2  3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3  4  2  3     3     3  4     4  4           4  3  2     4  3  3  3|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Amyloid Deposition                   | 3     2  1  1        3              2  4           2  2  2     3  2  3   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3        2  2  2     2  2  3  2     3  2     2           2     2  2  3  2|             
      Degeneration, Fatty                  |                                                                          |             
      Inflammation, Chronic, Focal         |                         2  1        1     1                       1      |             
      Mitotic Alteration                   |                                                    2                     |             
      Necrosis, Focal                      |       3                                                                  |             
      Centrilobular, Hypertrophy           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Granuloma                            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Hypertrophy, Focal           |                                                                          |             
      Interlobular, Edema                  | 3           1                 2     4  3     3        2              2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2     2        3  3     4     2  4     3     1  3  2     2  1  4  3|             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |                            2                                             |             
      Interlobular, Edema                  | 4                             4     2  4              3              2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                        X                                 |             
      Inflammation, Chronic                |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1                                          |             
      Amyloid Deposition                   |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|             
                                           | 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Thrombosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3     2  3  4        2     4  2     2  2     3     3  2  2     1  3  2  2|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Atrium, Thrombosis                   |             X                                X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3     3  1     2  2     2  2     2  2  2  2  2  2     1  2  2  4  2  3  3|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 3     3  2  2  3        3  2  3     1  3     4     3  3  3     2  3  4  2|             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |       2           2     3     4     4  3  3  2  2        2     1  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                            2                                             |             
      Necrosis                             |                      4                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  +  +  +  +  M  +  +  M  M  M  M  +  M  +  M  M  +  +  M|             
      Amyloid Deposition                   |       3                    2        4              1     2        2  2   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  I  +|             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3     2  2  3        1  2  3        2  2     2     2  3  3     1  2  3  2|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 | 3                 2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        3                                 |             
      Necrosis                             |                      4                                                   |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                +                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                                                     |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|             
                                           | 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I|             
      Inflammation, Chronic                |                3                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Dilatation                           |                                        3                                 |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
      Seminiferous Tubule, Necrosis        |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Myelofibrosis             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Amyloid Deposition                   |                      2                                                   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                      2                                         2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4        3  4        3     3        4  4     3        3  2     2  1  3   |             
      Hematopoietic Cell Proliferation     | 2  2  3  2     4  2     3  2     2     3  2     2  2     2     2  2  2  3|             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Pigmentation, Hemosiderin            |                         2                 2     2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Amyloid Deposition                   |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             1                                                            |             
      Abdominal, Edema                     |                                                                          |             
      Abdominal, Subcutaneous Tissue, Edema| 2           3                       2  2     2     3  3              3   |             
      Neck, Ulcer                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|             
                                           | 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Edema           | 2                                      3                                 |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Subcutaneous Tissue, Edema           |                                     2  2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      | 2  2              2     2        1        1  1  1        2     2  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |          2  3                                3           2     2         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                   2                                               2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                   2                                                      |             
      Artery, Amyloid Deposition           |                                     2                                    |             
      Interstitium, Inflammation, Chronic  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       X                                                                  |             
      Foreign Body                         |                      4  2                                                |             
      Fungus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |          +                                                               |             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Eye                                     | +              +                                                         |             
      Cataract                             | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4     3  4  4  4     4  4  3  4     4  4     4     3  4  4     3  4  4  2|             
      Nephropathy                          |    2                                                                    2|             
      Cortex, Atrophy, Focal               |                            3                             3               |             
      Cortex, Cyst                         |                   X                 X                    X               |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 1| 5| 5| 1| 2| 5| 0| 2| 5| 2| 5| 3| 0| 5| 1| 5| 5| 1| 5| 2| 5| 5| 7| 5|             
                                           | 6| 9| 3| 3| 2| 3| 3| 9| 1| 3| 0| 5| 2| 8| 5| 0| 5| 3| 4| 3| 2| 3| 3| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 MG/KG                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Focal                           |                                           1                              |             
      Pelvis, Dilatation                   |                                                                      3   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +                                      +|             
      Bulbourethral Gland, Dilatation      |                                  3                                      3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       1                                               3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5|                                            |            |
                                           | 7| 5| 5| 3| 4| 4| 4| 2| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Inflammation, Chronic                |       3                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Edema                                |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mucosa, Abscess                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |          2     2  3  2  4                                                |     27  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   | 3              3  4  3  4  3                                             |     37  3.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   |          2     2  3  2  4                                                |     30  2.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |          3     2  2  2                                                   |     34  2.2|
      Degeneration, Fatty                  |             2                                                            |      1  2.0|
      Inflammation, Chronic, Focal         | 2  1              2     3  1                                             |     18  1.6|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      2  3.0|
      Centrilobular, Hypertrophy           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Granuloma                            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Focal Cellular Change                | X                                                                        |      2     |
      Acinus, Amyloid Deposition           |                                                                          |      1  3.0|
      Acinus, Hypertrophy, Focal           |                                                                          |      1  2.0|
      Interlobular, Edema                  |          2              3                                                |     17  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2              2  3  3                                                   |     29  2.7|
      Infarct                              |          4                                                               |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Interlobular, Edema                  |                                                                          |     11  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5|                                            |            |
                                           | 7| 5| 5| 3| 4| 4| 4| 2| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |                                                                          |      1  1.0|
      Amyloid Deposition                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Thrombosis                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 1        3     2  2  3  3                                                |     35  2.5|
      Inflammation, Chronic, Focal         |                            2                                             |      1  2.0|
      Atrium, Thrombosis                   |          X           X                                                   |     10     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Capsule, Hyperplasia                 | 2     3  2  2  2  2  2  3  2                                             |     44  2.2|
      Corticomedullary Junction, Amyloid   |                                                                          |            |
          Deposition                       | 2        2        2  3  4                                                |     37  2.7|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     |    3  4     1  3     2     2                                             |     33  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Focal                   |                3                                                         |      3  2.7|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  M  M  +  +  +  M  M  M  M                                             |  24        |
      Amyloid Deposition                   |          4     2                                                         |     12  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Pars Distalis, Cyst                  |                      X                                                   |      3     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |          4     2  2  3                                                   |     33  2.4|
      C-Cell, Hyperplasia                  |       2                                                                  |      1  2.0|
      Follicle, Dilatation                 | 3        3                                                               |     11  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5|                                            |            |
                                           | 7| 5| 5| 3| 4| 4| 4| 2| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                                                                  |   2        |
      Abscess                              |       3                                                                  |      1  3.0|
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  M  +  +  +  +  +  +  +  +                                             |  56        |
      Inflammation, Chronic                |       2                                                                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Concretion                           |                3                                                         |      1  3.0|
      Dilatation                           |                3                                                         |      6  2.8|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
      Seminiferous Tubule, Atrophy         | 2                    2                                                   |      3  2.7|
      Seminiferous Tubule, Degeneration    |                                                                          |      3  2.7|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  3.0|
      Seminiferous Tubule, Necrosis        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Calvarium, Myelofibrosis             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 3                                                                        |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |                         3                                                |      4  2.3|
      Hematopoietic Cell Proliferation     | 3                                                                        |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Polyarteritis                        |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |          4     3     3  2                                                |     30  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5|                                            |            |
                                           | 7| 5| 5| 3| 4| 4| 4| 2| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     | 4  2  2     2  2  2  2  3  2                                             |     46  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |       2     1                                                            |      8  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  M  +  +  +  M  +                                             |  46        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  1.0|
      Abdominal, Edema                     |                                                                          |      1  2.0|
      Abdominal, Subcutaneous Tissue, Edema|                         3                                                |     18  2.3|
      Neck, Ulcer                          | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dermis, Inflammation, Chronic        |                                                                          |      2  2.0|
      Subcutaneous Tissue, Edema           |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |                      2                                                   |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thalamus, Mineralization, Focal      |                   2                                                      |     19  1.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  2.5|
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           | 2                                                                        |      2  2.5|
      Inflammation, Chronic, Focal         | 2  1              3  3                                                   |     13  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                      3                                                   |      5  2.4|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |          3           2  1                                                |      6  2.3|
      Artery, Amyloid Deposition           |                                                                          |      4  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 5| 5| 5| 5| 4| 5| 5|                                            |            |
                             DAY ON TEST   | 1| 5| 5| 5| 5| 5| 5| 9| 1| 5|                                            |            |
                                           | 7| 5| 5| 3| 4| 4| 4| 2| 0| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 MG/KG                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    VM                                     | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Inflammation, Chronic  |          3                                                               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                                                                          |      1     |
      Foreign Body                         |       3                                                                  |      4  3.3|
      Fungus                               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 3        4     4  3  4  4  2                                             |     44  3.5|
      Nephropathy                          |       1     1                                                            |      7  1.7|
      Cortex, Atrophy, Focal               |    3                                                                     |      4  3.0|
      Cortex, Cyst                         |          X        X        X                                             |      6     |
      Cortex, Renal Tubule, Mineralization,|                                                                          |            |
           Focal                           |                                                                          |      4  1.8|
      Pelvis, Dilatation                   |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Bulbourethral Gland, Dilatation      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|             
                                           | 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  A  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |                         2                                                |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |             3           3           3  2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2                 2                          2              3      |             
      Intussusception                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |       3     2           3     3  3  3  3  2  3     4        4  3  3  4  3|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   |       3     2        2  2     3  1        2        2        1  2  3  2  2|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2  2  2           2  3  2  1  2     2  3     3        1  1  2  2  2|             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Inflammation, Chronic, Focal         |          2  2  2                       1              1     2  2  2      |             
      Necrosis, Focal                      |                                                                   1      |             
      Pigmentation                         |                                                                   2      |             
      Centrilobular, Hypertrophy           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Polyarteritis                        |                                                                         4|             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition, Focal            |       3                                                                  |             
      Focal Cellular Change                |                                                                          |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
      Acinus, Hypertrophy, Focal           |                                                                   2      |             
      Interlobular, Edema                  |       2     2           3     2  3  2     3  3     2           2     2  2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3  2  3  2        3     3     3  4  4  4     3        3     2  4  3|             
      Interlobular, Edema                  |                         3        3  3     2  3     2                 3  3|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pylorus, Amyloid Deposition          |                                                                          |             
      Submucosa, Edema                     |                                              3                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|             
                                           | 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                               2                    2                     |             
      Submucosa, Inflammation, Acute       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3  3  2  2        3     3  2  1     2  2     3        2     3  2  2|             
      Atrium, Thrombosis                   |       X  X              X              X  X        X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2     2     2  2  2  3  3     2  3  2     2  2  2  2  3           3  2  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |       2  2  2  3        3     2  3  3     2  2     3           2  2  2  3|             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2  2  2  2  2  2  3  3  2              3  3  2  3        3        4      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                        2                                 |             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  M  M  +  M  M  M  +  M  M  M  M  I  M  M  M  M  +  +  +  M  +|             
      Amyloid Deposition                   |          4                    1                                2  2     3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Amyloid Deposition                   |       3  4              3     2           1  3     3           3  2     3|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Dilatation                 |                                  2                                2      |             
      Follicular Cell, Hyperplasia         |                                                       2     1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                         +               |             
      Hemorrhage                           |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                                                                2         |             
      Fat, Inflammation, Focal, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|             
                                           | 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                           2  3                 3         |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                             4            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                         3|             
      Granuloma                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3                 4     3  1  2  1  1  3     3           4     3   |             
      Hematopoietic Cell Proliferation     | 2  1     3  2  3  2           2  2  2  2  3  2  3  2  2  3  4     2  2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |          2                       2     2     2                       2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  A  +  I  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Abscess                              |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  A  M  M  M  M  M  +  M  M  M  M  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |             1                                                            |             
      Exudate, Focal                       |                                                                          |             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Abdominal, Subcutaneous Tissue, Edema|          3  3           3     3  3  4  3  2  3                 2     3   |             
      Face, Acanthosis                     |                                                                          |             
      Face, Exudate                        |                                                                          |             
      Forelimb, Right, Ulcer               |                                                                          |             
      Head, Ventral, Ulcer                 |                                                                          |             
      Neck, Acanthosis                     |                                                                          |             
      Neck, Fungus                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|             
                                           | 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Neck, Inflammation, Subacute         |                                                                          |             
      Neck, Ulcer                          |                                                             4            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |                                                                          |             
      Subcutaneous Tissue, Edema           |          2  3              2     3  3        3     2           2     2  3|             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Dermis, Inflammation, Chronic        |                                              1              1            |             
      Subcutaneous Tissue, Edema           |                                     3     3                    2     2  2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                         2|             
      Thalamus, Mineralization, Focal      |       1                       2                             3  1  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition, Focal            |                                                                          |             
      Congestion                           |          3        3                                                      |             
      Hemorrhage                           |                   3                                                      |             
      Inflammation, Chronic, Focal         |                         3                          3  2        2         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                                                      2   |             
      Artery, Amyloid Deposition           |                                                                          |             
      Interstitium, Inflammation, Chronic  |       2  2                             2           2        1        2   |             
      Vein, Embolus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                       2     2            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 4| 2| 4| 5| 3| 4| 4| 5| 5| 4|             
                             DAY ON TEST   | 5| 5| 4| 2| 4| 8| 5| 9| 5| 2| 4| 0| 5| 5| 4| 8| 9| 9| 5| 0| 4| 8| 5| 0| 9|             
                                           | 6| 6| 9| 6| 5| 6| 2| 7| 2| 0| 9| 3| 2| 2| 2| 6| 2| 3| 3| 4| 3| 2| 3| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                             4            |             
      Bilateral, Ulcer                     |                                                                          |             
      External Ear, Acanthosis             |                                                             4            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2  4  3  3     2  3  4  3  4  3  4  4  4     4        3  3  3  4  4|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |                   1                                                      |             
      Cortex, Atrophy, Focal               |                                                                          |             
      Cortex, Cyst                         |             X                    X                                       |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
           Focal                           |                                                       2  2               |             
      Pelvis, Dilatation                   |                               2              3                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                   3      |             
      Crystals                             |                                           2                              |             
      Mucosa, Hyperplasia                  |                                           2              3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|             
                             DAY ON TEST   | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|             
                                           | 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  M  M  +  A  +  M  +  M  +  +  +  +  +  +  +  +  A  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +|             
      Amyloid Deposition                   |                                     2                                    |             
      Edema                                |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |                   3                             3           3            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  M  +  M|             
      Amyloid Deposition                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          2     2     2  2  4  3                 2           2        2   |             
      Intussusception                      |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3  4  3  4  3  3  3  3  2     3  2     3  3        3  3     4  4   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  A  +  +  M  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  3  2     2  3     2  2  2                 2        3  3     4  3   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2  3  2  2  2  2  2  3  3     3  3     2  2           2     2  2   |             
      Hematopoietic Cell Proliferation     |                                                          3               |             
      Inflammation, Chronic, Focal         |                      1                    2  2                           |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         |                                                                          |             
      Centrilobular, Hypertrophy           |                                                                         2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Polyarteritis                        |                                                                          |             
      Fat, Necrosis, Focal                 |                                                          3               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition, Focal            |                                                                          |             
      Focal Cellular Change                |             X                                                            |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                       2                  |             
      Acinus, Hypertrophy, Focal           |                               3                                          |             
      Interlobular, Edema                  |    3     2     3  2                          3  2           2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  2  3  3  4  3  3     4  3     4  2     3  3        2        3  2   |             
      Interlobular, Edema                  |    3     3     2     3              4        3                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Pylorus, Amyloid Deposition          |                                                                   3      |             
      Submucosa, Edema                     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|             
                             DAY ON TEST   | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|             
                                           | 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                               2                                      2   |             
      Submucosa, Inflammation, Acute       |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2  3  3  4  3  2  3  3  4     2  2     2  3        2  2     3  3   |             
      Atrium, Thrombosis                   |             X  X  X        X  X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    2  2  2  2  2     1  3  2  3  2     2              2     2     2      |             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |    4  3  2  3  2  2     4  4  3     2  2     2  4           3     2  2   |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 3           2  2  2  1  3              3  2              2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
      Hypoplasia                           |                                           3                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  M  +  +  M  M  +  M  M  +  M  M  +  M  +  +  +  M  +|             
      Amyloid Deposition                   |    2        2           1  2                                2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2  3  2     2  2  2  2  1     2        2  3           2     2  2   |             
      Inflammation, Chronic                |                                        2                 2               |             
      Follicle, Dilatation                 |                   2                 3                    3     2         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Edema                                |                                                             3            |             
      Inflammation, Chronic                |          2                 2                                             |             
      Fat, Inflammation, Focal, Suppurative|                                                          4               |             
                                            __________________________________________________________________________|             
   Penis                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                    A                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|             
                             DAY ON TEST   | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|             
                                           | 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                           2                       1      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +|             
      Concretion                           |                                              3                           |             
      Dilatation                           |          2              1  3     3                    2                  |             
      Inflammation, Chronic                |                            2     2                          2            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                             2            |             
      Seminiferous Tubule, Atrophy         |    3              3        2                                3            |             
      Seminiferous Tubule, Degeneration    |                                  3                                       |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             2        2              2                                    |             
      Granuloma                            | 4                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  3  2  2  3  2  1  2  3  4     2  1     2  3           2     2      |             
      Hematopoietic Cell Proliferation     | 3  3  2  2  3     2  2  2  2     2  2  4  2  2  2     2  3  3  2  2     2|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
      Pigmentation, Hemosiderin            |                   2                          2  2              2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  A  +  +  +  +  M  M  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  A  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Exudate, Focal                       |                                                             2            |             
      Abdominal, Dermis, Inflammation,     |                                                                          |             
           Chronic                         |                                                          2               |             
      Abdominal, Subcutaneous Tissue, Edema|    4     3     4  3                 2        3           3        2      |             
      Face, Acanthosis                     |    2                                                                     |             
      Face, Exudate                        |    2                                                                     |             
      Forelimb, Right, Ulcer               |                                                                          |             
      Head, Ventral, Ulcer                 |                                                                          |             
      Neck, Acanthosis                     |                                        2                                 |             
      Neck, Fungus                         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|             
                             DAY ON TEST   | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|             
                                           | 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Neck, Inflammation, Subacute         |                                        4                                 |             
      Neck, Ulcer                          |                                        4                                 |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |          2                                                               |             
      Subcutaneous Tissue, Edema           |          3     3     2              2                       3     2      |             
      Subcutaneous Tissue, Hemorrhage      |                      2                                                   |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                         2                                                |             
      Hyperkeratosis                       |                         2                                                |             
      Ulcer                                |                                                 2                        |             
      Dermis, Inflammation, Chronic        |                                     3                                    |             
      Subcutaneous Tissue, Edema           |    4           3                    2                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Thalamus, Mineralization, Focal      | 1           2     3        1                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition, Focal            |                   2                             3                        |             
      Congestion                           |       3     3                          2                                 |             
      Hemorrhage                           |                                     2                                    |             
      Inflammation, Chronic, Focal         |                         2  3  2                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                      2                                                   |             
      Artery, Amyloid Deposition           |                                                                          |             
      Interstitium, Inflammation, Chronic  | 4                                      2                 1        2      |             
      Vein, Embolus                        |                                                                         4|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 5| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 4| 5| 5| 4| 5| 3| 5| 3| 5| 5| 4| 5| 0|             
                             DAY ON TEST   | 9| 0| 3| 8| 7| 1| 6| 9| 5| 2| 5| 5| 4| 4| 5| 4| 1| 9| 5| 3| 2| 5| 7| 1| 5|             
                                           | 0| 3| 8| 6| 0| 4| 3| 0| 2| 8| 2| 5| 7| 7| 5| 2| 2| 7| 4| 2| 4| 4| 0| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    40 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Bilateral, Ulcer                     |                                                                          |             
      External Ear, Acanthosis             |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                    M   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    4  3  4  3  4  3  3  4  4  3     4  4     3           2  4     4  4   |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                    4                     |             
      Nephropathy                          |                                  1              4     2                  |             
      Cortex, Atrophy, Focal               |                               3                                          |             
      Cortex, Cyst                         |             X     X  X                 X                    X            |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
           Focal                           |                                                                          |             
      Pelvis, Dilatation                   |    2                                   2                                 |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                     +                                    |             
      Bulbourethral Gland, Dilatation      |                                     4                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Crystals                             |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 5| 5| 1| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4|                                            |            |
                                           | 9| 6| 5| 5| 2| 2| 1| 8| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Amyloid Deposition                   |                                                                          |      2  2.0|
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Amyloid Deposition                   |    3                                                                     |      1  3.0|
      Edema                                |                                                                          |      7  2.9|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Amyloid Deposition                   |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Amyloid Deposition                   | 2  4     3     2     2     3                                             |     19  2.4|
      Intussusception                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Amyloid Deposition                   | 3  3  4  4  3  3     3     4                                             |     40  3.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  M  +  +  +  +  +  +  +  +                                             |  51        |
      Amyloid Deposition                   | 2     2  1     2     2     4                                             |     32  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   | 2  3  3  3  1  2     2     2                                             |     41  2.2|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         |       2                                                                  |     12  1.8|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Centrilobular, Hypertrophy           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Polyarteritis                        |                                                                          |      1  4.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition, Focal            |                                                                          |      1  3.0|
      Focal Cellular Change                |                                                                          |      1     |
      Acinus, Amyloid Deposition           |    3                                                                     |      1  3.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
      Acinus, Hypertrophy, Focal           |                                                                          |      2  2.5|
      Interlobular, Edema                  |    2     3     2           2                                             |     23  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   | 3  3  2  3  2  2     3     3                                             |     39  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 5| 5| 1| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4|                                            |            |
                                           | 9| 6| 5| 5| 2| 2| 1| 8| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Interlobular, Edema                  |                                                                          |     14  2.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pylorus, Amyloid Deposition          |                                                                          |      1  3.0|
      Submucosa, Edema                     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   |    2                                                                     |      5  2.0|
      Submucosa, Inflammation, Acute       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                      +                                                   |   1        |
      Polyarteritis                        |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2  4  3  4  1  3     2     2                                             |     41  2.5|
      Atrium, Thrombosis                   | X  X  X  X     X                                                         |     16     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Capsule, Hyperplasia                 | 2  2  2        2           2                                             |     37  2.2|
      Corticomedullary Junction, Amyloid   |                                                                          |            |
          Deposition                       | 2  2  3  2  2  2     3     2                                             |     39  2.5|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     | 2  2        2              2                                             |     28  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Hypoplasia                           |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  M  +  M  M  +  M                                             |  25        |
      Amyloid Deposition                   | 2  4           2                                                         |     13  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Pars Distalis, Cyst                  |       X        X                                                         |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Amyloid Deposition                   | 3  4  4  3     2           2                                             |     30  2.5|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Follicle, Dilatation                 |                         2                                                |      7  2.3|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 5| 5| 1| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4|                                            |            |
                                           | 9| 6| 5| 5| 2| 2| 1| 8| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Fat, Inflammation, Focal, Suppurative|                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |       +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia, Focal                   |             2                                                            |      2  2.0|
      Inflammation, Chronic                |                         2                                                |      3  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Concretion                           |                                                                          |      1  3.0|
      Dilatation                           |                            2                                             |      6  2.2|
      Inflammation, Chronic                |       2                    2                                             |      5  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                      3                                                   |      8  2.8|
      Seminiferous Tubule, Degeneration    |                                                                          |      1  3.0|
      Seminiferous Tubule, Mineralization  |                      3  2                                                |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Plasma Cell             |                   4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   |                            2                                             |      5  2.2|
      Granuloma                            |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition                   | 4  4  4  4     2     3                                                   |     33  2.6|
      Hematopoietic Cell Proliferation     |       1  2  2  2  3  2  2  2                                             |     49  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      9  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  I  +  +  I  +  +  +  +                                             |  45        |
      Abscess                              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 5| 5| 1| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4|                                            |            |
                                           | 9| 6| 5| 5| 2| 2| 1| 8| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  1.0|
      Exudate, Focal                       |                                                                          |      1  2.0|
      Abdominal, Dermis, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Abdominal, Subcutaneous Tissue, Edema| 3              2     3  2  3                                             |     24  2.9|
      Face, Acanthosis                     |                                                                          |      1  2.0|
      Face, Exudate                        |                                                                          |      1  2.0|
      Forelimb, Right, Ulcer               |                   4                                                      |      1  4.0|
      Head, Ventral, Ulcer                 |                   4                                                      |      1  4.0|
      Neck, Acanthosis                     |                                                                          |      1  2.0|
      Neck, Fungus                         |                                                                          |      1  2.0|
      Neck, Inflammation, Subacute         |                                                                          |      1  4.0|
      Neck, Ulcer                          |                                                                          |      2  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dermis, Inflammation, Chronic        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |                2                                                         |     17  2.5|
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                   2     2                                                |      3  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Dermis, Inflammation, Chronic        |       2                 2                                                |      6  1.8|
      Subcutaneous Tissue, Edema           |                                                                          |      8  2.6|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Thalamus, Mineralization, Focal      |    2                 1                                                   |     11  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 5| 5| 1| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4|                                            |            |
                                           | 9| 6| 5| 5| 2| 2| 1| 8| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Amyloid Deposition, Focal            |                                                                          |      2  2.5|
      Congestion                           |                                                                          |      5  2.8|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Chronic, Focal         | 3              2                                                         |      9  2.4|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                         1                                                |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |    4  3  3                                                               |      5  2.8|
      Artery, Amyloid Deposition           |    3                                                                     |      1  3.0|
      Interstitium, Inflammation, Chronic  |    4  3  3           2  3                                                |     15  2.3|
      Vein, Embolus                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Foreign Body                         |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                   +     +                                                |   3        |
      Ulcer                                |                                                                          |      1  4.0|
      Bilateral, Ulcer                     |                   4     4                                                |      2  4.0|
      External Ear, Acanthosis             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 3  4  4  4  2  3     4     4                                             |     44  3.5|
      Hydronephrosis                       |                         2                                                |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Nephropathy                          |                                                                          |      4  2.0|
      Cortex, Atrophy, Focal               |    2                    2                                                |      3  2.3|
      Cortex, Cyst                         |                X        X                                                |      9     |
      Cortex, Renal Tubule, Mineralization,|                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
      Pelvis, Dilatation                   |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Bulbourethral Gland, Dilatation      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 5| 4| 5| 5| 1| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 4| 8| 5| 7| 5| 4| 2| 2| 5| 4|                                            |            |
                                           | 9| 6| 5| 5| 2| 2| 1| 8| 2| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    40 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     LM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Crystals                             |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|             
                                           | 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  A|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Edema                                |                3                                                  3      |             
      Hemorrhage                           |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +  +  M|             
      Amyloid Deposition                   | 2        2  2                       1     1     1                 1      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   | 2     3  2  3  3     3        4     2     3     3  4        3     4     4|             
      Edema                                |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|             
      Amyloid Deposition                   | 2     1  2  2  2     3        2     2     3     3  3        2     3      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3        2  2  2        3     2     2     2  3  2  3        3     3      |             
      Granuloma                            |                                           3                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic, Focal         |       2     1              2  2                       1  2  2            |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Polyarteritis                        |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                       X                  |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Duct, Cyst                           |                                                                          |             
      Interlobular, Edema                  |          2  2  2              2     2        2     2              3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        3  3  3  3  2                       2  3  3     2  4     4  3  2|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Interlobular, Edema                  |          3  2     2                       2                       3      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3                                         3                 2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|             
                                           | 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Polyarteritis                        |                                                    3                     |             
      Aorta, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        2  2  2        2     3     4     3  3  2  3        4     2  2   |             
      Fibrosis                             |                                                             4            |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Focal                      |                                                          2               |             
      Polyarteritis                        |                      2                                                   |             
      Atrium, Thrombosis                   |             X     X                 X                             X      |             
      Pericardium, Inflammation, Focal,    |                                                                          |             
           Subacute                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1  2     2           2  3  2     1  2  2     2  3  2  2  1        2  2  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 3        2  2  2  2     3     1  2  4        2  3  3        2     3  2   |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |             3     2  2  2  2  3           3  2  3  2  2  2  2     2  3  2|             
      Extra Adrenal Tissue, Hemorrhage     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  M  M  M  M  +  +  M  +  M  +  +  +  M  +  M  M  +  M  +  M|             
      Amyloid Deposition                   | 3                                   2        2                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  I  M  +  +  +|             
      Pars Distalis, Cyst                  |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2        2  2     2     1     2     2        2     2        3     4  2   |             
      Inflammation, Chronic                |    2                                                                     |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 |                         2                             2  3               |             
      Follicular Cell, Hyperplasia         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|             
                                           | 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |    +                                   +     +                           |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                      M   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  I  +  +|             
      Inflammation, Chronic                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                    3  3                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Granuloma Sperm                      |                         2                                                |             
      Seminiferous Tubule, Atrophy         |                                     1                                    |             
      Seminiferous Tubule, Degeneration    |                            1  1                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                           2              2               |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 4        2     2  3                 2        4     3  2     3     2      |             
      Hematopoietic Cell Proliferation     |    2  3        3  2  2     2  3  2  2     3  2  3  3     2  2  2  2  2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                           2              2     1     2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  I  +  +  M  +  I  M  +|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Abdominal, Subcutaneous Tissue, Edema|             2     3  2        4                    3              3      |             
      Foot, Ulcer                          |                                                                          |             
      Neck, Subcutaneous Tissue, Hemorrhage|       3                                                                  |             
      Tail, Inflammation, Chronic          |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|             
                                           | 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |             2  2              4     3                                    |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 3                        |             
      Exudate                              |                                                 2                        |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                 2                        |             
      Dermis, Inflammation, Chronic        |                                                                          |             
      Subcutaneous Tissue, Edema           |             3                 3                             1     2      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Hyperostosis                |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |    1     1  2     1  1     1        1                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Hemorrhage                           |                      2                                                   |             
      Inflammation, Chronic, Focal         |    3     1  3                 2     2           3  2        2     3      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                     2                 2                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                      3  3                                         3     4|             
      Artery, Amyloid Deposition           |                                                             3            |             
      Interstitium, Inflammation, Chronic  |                      3                                   2              3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |       3                                                                  |             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
      Septum, Amyloid Deposition           |                                                                          |             
      Sinus, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Ulcer                                |                                                                          |             
      Bilateral, Ulcer                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 4| 5| 2|             
                             DAY ON TEST   | 5| 5| 2| 9| 7| 1| 3| 3| 1| 5| 3| 2| 1| 1| 5| 1| 5| 1| 5| 8| 1| 5| 5| 5| 9|             
                                           | 3| 3| 1| 3| 5| 0| 7| 3| 2| 6| 1| 0| 9| 2| 2| 0| 2| 0| 2| 3| 8| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3        3  3  4  3  3  3     4  2  4     3  3  3  4     2  4     4  3   |             
      Hemorrhage                           |                                                          3               |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |                                                       1                  |             
      Cortex, Atrophy, Focal               |                            3                                             |             
      Cortex, Cyst                         |                                     X                 X                  |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
           Focal                           |                                                                          |             
      Pelvis, Dilatation                   |             3  2                                            2            |             
      Perirenal Tissue, Hemorrhage         |                                                          3               |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +                                       |             
      Bulbourethral Gland, Dilatation      |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                     2                                    |             
      Hemorrhage                           |                                              2                           |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|             
                                           | 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  A  +  +  +  +  +  A  +  M  +  +  A  M  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  A  +|             
      Edema                                |          3                                                               |             
      Hemorrhage                           |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  A  +  M  M  +  +  +  +  +  +  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Amyloid Deposition                   |                                        3                                3|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
      Amyloid Deposition                   |    2     1  2  3     4           3  4  4           3  2  3     3     3  4|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  A  +|             
      Amyloid Deposition                   |          3  2        2                 4           2  2  3     3        3|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3  2  2     3        2  1                 1  2  2        2  4  3|             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Inflammation, Chronic, Focal         | 2     2        2           2           2        2              2     2   |             
      Mitotic Alteration                   |                                                                3         |             
      Necrosis, Focal                      |                2                                                         |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Acinus, Amyloid Deposition           |                                                                      2  3|             
      Duct, Cyst                           |                                                    X                     |             
      Interlobular, Edema                  |          3     2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3     4  4  3     1        4  3           3     2  2  3        3  3  4|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Interlobular, Edema                  |          2                    2  3                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|             
                                           | 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
      Polyarteritis                        |                                                                          |             
      Aorta, Inflammation, Chronic         |                               3                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2     2  4  3     4        2                       3  2     2  2  2  4|             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Atrium, Thrombosis                   |    X        X        X                                            X     X|             
      Pericardium, Inflammation, Focal,    |                                                                          |             
           Subacute                        |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  2  3  2  2     4     2  2           2     2  2     1     2        1  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |    2     2  2  3     4           1           3     2  2        1  3     3|             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2     3     2           2  3                 2  2     2  2  2  2     2   |             
      Extra Adrenal Tissue, Hemorrhage     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2                                                                        |             
      Hypertrophy, Focal                   |                            3                       3                     |             
      Hypoplasia                           |                                                 3                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  M  M  +  +  M  M  +  M  M  +  M  M  M  M  M|             
      Amyloid Deposition                   |    3        2        3                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Cyst                  |                X                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3        2  1     4        4                    2              2  2  3|             
      Inflammation, Chronic                |                                                                          |             
      C-Cell, Hyperplasia                  |                         1                                                |             
      Follicle, Dilatation                 | 2     2     2     2                             2              2         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                             +              +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|             
                                           | 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          3                                                               |             
      Granuloma Sperm                      |                                                          2               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
      Granuloma Sperm                      |                                                                          |             
      Seminiferous Tubule, Atrophy         |          3     4                 3                       3               |             
      Seminiferous Tubule, Degeneration    |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                     3  3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |             2                    3                                2     2|             
      Granuloma                            |                                        4                                 |             
      Hemorrhage                           |                                              4                       3   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          2  3        3        4                       1  3        2  3  4|             
      Hematopoietic Cell Proliferation     | 2  2  2  3     2     2  2     1  2  3  3  1  3  2  3  3     3  3  2  3   |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Pigmentation, Hemosiderin            |                         2                       2  2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  A  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  M  M|             
      Depletion Lymphoid                   |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               1                                          |             
      Abdominal, Subcutaneous Tissue, Edema|          1     2              3  3                       3        2      |             
      Foot, Ulcer                          |                                                                          |             
      Neck, Subcutaneous Tissue, Hemorrhage|                                                                          |             
      Tail, Inflammation, Chronic          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|             
                                           | 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema           |          2                    3                          2               |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                2         |             
      Exudate                              |                                                    X                     |             
      Hyperkeratosis                       |                                                                2         |             
      Ulcer                                |                                                                      4   |             
      Dermis, Inflammation, Chronic        |                               1                                2         |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternum, Hyperostosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization, Focal      |    1                             2           1  1                       1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                 3                                      2   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |                      3                                                  2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                                              4                           |             
      Artery, Amyloid Deposition           |                                                                          |             
      Interstitium, Inflammation, Chronic  |    2        2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                       2                  |             
      Fungus                               |                                                                          |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Hyperplasia       |                                     2                                    |             
      Septum, Amyloid Deposition           |                                                       2                  |             
      Sinus, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +  +                    +        +   |             
      Ulcer                                |                                        4                    4            |             
      Bilateral, Ulcer                     |                                     4                                    |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 4| 5| 1| 3| 5| 4| 5| 5| 5| 5| 5| 5| 5| 4| 5|             
                             DAY ON TEST   | 5| 4| 5| 4| 4| 1| 5| 5| 5| 5| 2| 1| 2| 2| 5| 3| 5| 5| 5| 0| 5| 5| 3| 5| 5|             
                                           | 5| 5| 5| 2| 7| 7| 3| 3| 3| 3| 3| 4| 1| 5| 6| 5| 6| 6| 6| 0| 6| 6| 6| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    80 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3     4  3  4     4        4  4           3     3  3  4     3  4  3  4|             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                          4               |             
      Inflammation, Suppurative            |                         1                                                |             
      Nephropathy                          | 1     2           1        1                    1                        |             
      Cortex, Atrophy, Focal               |                                                                      3   |             
      Cortex, Cyst                         |             X                                         X  X               |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
           Focal                           |                         1                                                |             
      Pelvis, Dilatation                   |                                                                          |             
      Perirenal Tissue, Hemorrhage         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +               |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                  3                       2               |             
      Hemorrhage                           |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 5| 4| 5| 4| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5|                                            |            |
                                           | 2| 2| 2| 4| 4| 8| 4| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Edema                                |                2                                                         |      4  2.8|
      Hemorrhage                           |          4                                                               |      1  4.0|
      Polyarteritis                        |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +                                             |  50        |
      Amyloid Deposition                   |    2  2              2                                                   |     12  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Amyloid Deposition                   | 3  2  3  3     3  3  2  3                                                |     36  2.9|
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +                                             |  51        |
      Amyloid Deposition                   |    2  3  2        1  2  3                                                |     28  2.4|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2  2  3     1     2  2                                                |     31  2.3|
      Granuloma                            |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                   3                                                      |      2  2.5|
      Inflammation, Chronic, Focal         |                   3     2                                                |     17  1.9|
      Mitotic Alteration                   |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Necrosis                             | 2                                                                        |      1  2.0|
      Bile Duct, Hyperplasia               |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Polyarteritis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Focal Cellular Change                |          X                                                               |      2     |
      Inflammation, Focal, Suppurative     |          2                                                               |      1  2.0|
      Polyarteritis                        |       3                                                                  |      1  3.0|
      Acinus, Amyloid Deposition           |                   1                                                      |      3  2.0|
      Duct, Cyst                           |                                                                          |      1     |
      Interlobular, Edema                  |                3                                                         |     11  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |    2  2  3     2  3                                                      |     33  2.8|
      Inflammation, Focal, Suppurative     |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 5| 4| 5| 4| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5|                                            |            |
                                           | 2| 2| 2| 4| 4| 8| 4| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Interlobular, Edema                  |          2                                                               |      9  2.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Polyarteritis                        |                                                                          |      1  3.0|
      Aorta, Inflammation, Chronic         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Amyloid Deposition                   | 3  2  3  3     2  2  3  2                                                |     34  2.6|
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Acute                  | 2                                                                        |      1  2.0|
      Necrosis, Focal                      | 2                                                                        |      2  2.0|
      Polyarteritis                        |    2                                                                     |      2  2.0|
      Atrium, Thrombosis                   |                                                                          |      9     |
      Pericardium, Inflammation, Focal,    |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Capsule, Hyperplasia                 | 2     2  2     1  2  2  2  2                                             |     40  2.0|
      Corticomedullary Junction, Amyloid   |                                                                          |            |
          Deposition                       |    2  2  3           2  3                                                |     32  2.4|
      Corticomedullary Junction,           |                                                                          |            |
          Pigmentation                     | 2        3     2  2  2  3  2                                             |     35  2.3|
      Extra Adrenal Tissue, Hemorrhage     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      2  3.0|
      Hypoplasia                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  M  +  M  M  M  +                                             |  26        |
      Amyloid Deposition                   |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  M  +  +  +  +  +                                             |  50        |
      Pars Distalis, Cyst                  |                         X                                                |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  M  +  +  +                                             |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 5| 4| 5| 4| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5|                                            |            |
                                           | 2| 2| 2| 4| 4| 8| 4| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Amyloid Deposition                   |       2              2  1                                                |     24  2.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicle, Dilatation                 |                2        3                                                |     11  2.2|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  3.0|
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Inflammation, Chronic                |                2  3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Penis                                   |          M           +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                            2                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1     |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                3  2                                                      |      7  2.7|
      Seminiferous Tubule, Degeneration    |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |             4                                                            |      1  4.0|
      Amyloid Deposition                   |                                                                          |      6  2.2|
      Granuloma                            |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      2  3.5|
      Hyperplasia                          |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 5| 4| 5| 4| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5|                                            |            |
                                           | 2| 2| 2| 4| 4| 8| 4| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Amyloid Deposition                   |    1     3     3     2                                                   |     23  2.7|
      Hematopoietic Cell Proliferation     | 3  2  2     2  2  3  2  2  2                                             |     48  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                2                                                         |      9  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +                                             |  43        |
      Depletion Lymphoid                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  1.0|
      Abdominal, Subcutaneous Tissue, Edema|          3     3  4  2                                                   |     16  2.7|
      Foot, Ulcer                          |    4                                                                     |      1  4.0|
      Neck, Subcutaneous Tissue, Hemorrhage|                                                                          |      1  3.0|
      Tail, Inflammation, Chronic          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Subcutaneous Tissue, Edema           |          3        1                                                      |      9  2.4|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |    2                                                                     |      3  2.3|
      Exudate                              |                                                                          |      2  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Ulcer                                |    2                                                                     |      3  2.7|
      Dermis, Inflammation, Chronic        |                   1  2                                                   |      5  1.6|
      Subcutaneous Tissue, Edema           |          2                                                               |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Sternum, Hyperostosis                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Thalamus, Mineralization, Focal      |    1     1  2  2                                                         |     16  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      4  2.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                   3  2                                                   |     13  2.4|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 5| 4| 5| 4| 4| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 5| 5| 5| 5| 5| 6| 5| 5| 5|                                            |            |
                                           | 2| 2| 2| 4| 4| 8| 4| 0| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SWISS WEBSTER MICE MALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    80 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     MM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                   3                                                      |      6  3.3|
      Artery, Amyloid Deposition           |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  | 2                                                                        |      6  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               |          2                                                               |      1  2.0|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  3.0|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  2.0|
      Septum, Amyloid Deposition           |                                                                          |      1  2.0|
      Sinus, Inflammation, Chronic         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  M  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   4        |
      Ulcer                                |                                                                          |      2  4.0|
      Bilateral, Ulcer                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   | 2  4  3  4     3  4  4  3                                                |     41  3.4|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydronephrosis                       |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Nephropathy                          |                                                                          |      6  1.2|
      Cortex, Atrophy, Focal               |                                                                          |      2  3.0|
      Cortex, Cyst                         |    X     X                                                               |      7     |
      Cortex, Renal Tubule, Mineralization,|                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Pelvis, Dilatation                   |    2                                                                     |      4  2.3|
      Perirenal Tissue, Hemorrhage         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +                                                            |   3        |
      Bulbourethral Gland, Dilatation      |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Amyloid Deposition                   |                                                                          |      3  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|             
                             DAY ON TEST   | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|             
                                           | 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Edema                                |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  M  +  +  +  +  +  +  A  A  +  +  +  +  A  A  +  +  +|             
      Amyloid Deposition                   |    2     3                                      2        3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3  3  3  3     3  3  3  3              3        2     3  4  4  4  2  4  4|             
      Edema                                |                                                                          |             
      Hemorrhage                           | 4                                                                        |             
      Necrosis                             | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  A  A  +  +  +|             
      Amyloid Deposition                   |    2     3     3  2  3  3                       2     2  3           1   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  2  2  2     2  3  2  2                 2     2     2  2  2  1         |             
      Hematopoietic Cell Proliferation     |                                                                   4      |             
      Inflammation, Chronic, Focal         |                                        2                                 |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                3                                                         |             
      Acinus, Amyloid Deposition           |                                                                          |             
      Interlobular, Edema                  |    2           2  3  4                                   2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  2  1     3  3  3  2                 3     3     2  3  3  1     3  2|             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Interlobular, Edema                  |                3        2                                            2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|             
                             DAY ON TEST   | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|             
                                           | 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Aorta, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  2  2  2     2  2  3  3                 3     3     2  3  2  2     3   |             
      Necrosis, Focal                      |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Atrium, Thrombosis                   |                      X                    X           X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    2  2  2  2  1     2        2     3     2     3  3  3  2        2  3  2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       | 2  2     3        3  2  1                       2     3  2  2  1        1|             
      Corticomedullary Junction,           |                                                                          |             
          Mineralization, Focal            |                                                                          |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     | 2  1  3  2     3     2  2        2  4        2  2     3        2  2  3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  M  +  M  M  M  M  +  +  +  M  +  +  M  +  +  M  +  M  M  +  +|             
      Amyloid Deposition                   |                                           4           2                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2           2     2                 4     2     2  2              1|             
      Inflammation, Chronic                |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 |                                  2  2                             2  3   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                 +                        |             
      Dilatation                           |                                                 2                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|             
                             DAY ON TEST   | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|             
                                           | 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                         |             
      Inflammation, Acute                  |                2                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Abscess                              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  I  +  M  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                   4      |             
      Dilatation                           |                                     2                                    |             
      Inflammation, Chronic                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Testes                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |    2                             3                                       |             
      Seminiferous Tubule, Degeneration    |          2                                                               |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
      Tunic, Inflammation, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |                                                                2        3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          3               |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 2  3  2  2     3  3  3  2                 3     1     2  4  2            |             
      Hematopoietic Cell Proliferation     | 2        2  2  2        3  2  2  2  2  2  2     2  3  2     2  3  3  3  2|             
      Pigmentation, Hemosiderin            |    2                                                                    2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  M  M  +  +  I  +  M  +  +  +  I  +  M  M  +  M  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1                                          |             
      Edema                                |                                                                          |             
      Abdominal, Inflammation, Chronic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|             
                             DAY ON TEST   | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|             
                                           | 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abdominal, Subcutaneous Tissue, Edema|    2           3  3  4                    3                       2      |             
      Face, Ulcer                          |                                                                          |             
      Head, Ulcer                          |                         4                                                |             
      Other, Inflammation, Chronic         |                                                                          |             
      Other, Ulcer                         |                                                                          |             
      Subcutaneous Tissue, Other, Abscess  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Inflammation, Chronic        |                   2                                                      |             
      Subcutaneous Tissue, Edema           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Dermis, Inflammation, Chronic        |                               2                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Thalamus, Mineralization, Focal      |          1                                         2  2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                 2                                            2        2|             
      Hemorrhage                           |                         2                          3                     |             
      Inflammation, Chronic, Focal         |                                     2     1                    2     1   |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |          2                                                               |             
      Interstitium, Inflammation, Chronic  |                         2                             3           2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                4         |             
      Hemorrhage                           |                                                    3                     |             
      Inflammation, Suppurative            |                                                                4         |             
      Septum, Amyloid Deposition           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                         +     +                       +                  |             
      Ulcer                                |                         4     4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 5| 5| 5| 5| 4| 1| 5| 4| 5| 5| 5| 3| 5| 4| 4|             
                             DAY ON TEST   | 8| 6| 5| 5| 5| 8| 4| 7| 9| 5| 5| 5| 5| 5| 4| 9| 5| 2| 5| 5| 1| 8| 2| 0| 4|             
                                           | 7| 3| 3| 3| 3| 4| 2| 8| 3| 3| 3| 3| 6| 5| 2| 5| 6| 0| 3| 6| 3| 5| 8| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    160                                    | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Pinna, Inflammation, Chronic         |                                                       4                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Lids, Inflammation, Chronic          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   | 3  3  2  3     4  3  3  4              2  4     3     4  4  3  2     3   |             
      Atrophy, Diffuse                     |                               4                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                   3      |             
      Inflammation, Suppurative            |                         4                                            3   |             
      Nephropathy                          |                                  1                                      1|             
      Cortex, Cyst                         |    X                          X                          X               |             
      Cortex, Renal Tubule, Mineralization,|                                                                          |             
           Focal                           |                                                                   1      |             
      Pelvis, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 | +                                                                        |             
      Bulbourethral Gland, Dilatation      | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Crystals                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|             
                             DAY ON TEST   | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|             
                                           | 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  M  +  +  M  +  +  +  +  A  +  +  +  +  +  A  +  A  +|             
      Hyperplasia, Lymphoid                |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |                         1                                                |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                         2                                                |             
      Edema                                |                                                                   3      |             
      Polyarteritis                        |                                           2     3                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  A  +  +  M  +  +  A  +  +  +|             
      Amyloid Deposition                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |    2                    2                 1           1           1      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    3  4  3  1  4  3     4  4     4        3     3  4  4        4  4  3   |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
      Amyloid Deposition                   |          3        3     2        1        2           3           2  3   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2  2        2     3  2  2  3        2     2     2        3  2      |             
      Hematopoietic Cell Proliferation     |             4                                                            |             
      Inflammation, Chronic, Focal         | 1              2  2     2  2        2  2           2     1  2           1|             
      Necrosis, Focal                      |                2        3  2     3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                                                                          |             
      Acinus, Amyloid Deposition           |                2                                                         |             
      Interlobular, Edema                  |       3  2        2                       2     2     2           2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |    2  2           2     4     2  3        3     3              3  2      |             
      Inflammation, Focal, Suppurative     |                   3                                                      |             
      Interlobular, Edema                  |                   3        1              2  3                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Edema                     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 109                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|             
                             DAY ON TEST   | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|             
                                           | 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Aorta, Inflammation, Chronic         |                                                    4                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       2  1  2           1  2  2  2        1  2  2     4        2  2      |             
      Necrosis, Focal                      |                                                    3                     |             
      Polyarteritis                        |          2                                                               |             
      Atrium, Thrombosis                   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  2  2  2  3  1  2     2  2  2  2     3  2     2     2  3              2|             
      Corticomedullary Junction, Amyloid   |                                                                          |             
          Deposition                       |       2  3     2        3  2  2  4        2     2     3        2         |             
      Corticomedullary Junction,           |                                                                          |             
          Mineralization, Focal            |                         2                                                |             
      Corticomedullary Junction,           |                                                                          |             
          Pigmentation                     |    3        3     2  2  4     3     2  2     2  2     3  2  2  2        2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                               3                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |    2                                                                     |             
      Necrosis                             |                                                                   4      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  M  +  M  M  +  M|             
      Amyloid Deposition                   |          1  2                             2           3                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |             2              2  2  2           2        3        3         |             
      Inflammation, Chronic                |                                                                          |             
      C-Cell, Hyperplasia                  |                                        2                                 |             
      Follicle, Dilatation                 |       3              2                    3        3           2         |             
      Follicular Cell, Hyperplasia         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 110                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|             
                             DAY ON TEST   | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|             
                                           | 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    160                                    | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    MG/KG HM                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Granuloma Sperm                      |       2                                                                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                +         |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                                    |             
      Abscess                              |                                     4                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         3                          4                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Dilatation                           |                                              2                       3  3|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |       2  2                             2  3                       3      |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
      Tunic, Inflammation, Suppurative     |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia             |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Amyloid Deposition                   |       2                                                                  |             
      Hematopoietic Cell Proliferation     |                         4                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                3                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |       3  3              3        2        2  3  2     2           2      |             
      Hematopoietic Cell Proliferation     | 2  3  2     4  3  3  2  3  3     3  2  2  2  2  2  3  2  2  2  3  2  2  2|             
      Pigmentation, Hemosiderin            | 2     2                 3              2     2              1            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  I  +  +  +  +  M  M  +  +  M  +  I  I  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Edema                                |                                           1                              |             
      Abdominal, Inflammation, Chronic     |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 111                                                               
NTP Experiment-Test: 05098-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           P-NITROPHENOL                                       Date: 04/28/97  
Route: DERMAL,SOLUTION                                                                                            Time: 07:07:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 4| 4| 4| 3| 4| 5| 4| 5| 4| 4| 5| 5| 5| 4| 5| 2| 5| 5| 5| 4| 4| 3| 5|             
                             DAY ON TEST   | 5| 5| 8| 7| 7| 9| 8| 5| 2| 5| 3| 8| 5| 5| 0| 8| 0| 6| 2| 5| 5| 1| 4| 1| 5|             
                                           | 5| 5| 2| 8| 4| 5| 4| 3| 7| 3| 7| 6| 6| 6| 9| 0| 4| 8| 8| 6| 6| 2| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SWISS WEBSTER MICE MALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9|