TDMS Study 05098-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Hazelton, MD DATE: 09/13/94
EXP: 05098 P-NITROPHENOL TIME: 14:12:51
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DERMAL,SOLUTION NTP C#: 55992B
CONT: NO1ES45040 CAS: 100-02-7
PATHOLOGIST: R. CARDY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Hazelton, MD DATE: 09/13/94
EXP: 05098 P-NITROPHENOL TIME: 14:12:51
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DERMAL,SOLUTION NTP C#: 55992B
CONT: NO1ES45040 CAS: 100-02-7
PATHOLOGIST: R. CARDY S. EUSTIS
P-NITROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 552 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 4 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 222 397 409 412 419 423 475 485 486 486 |
| 486 492 493 508 510 510 510 512 514 517 |
| 519 520 521 530 532 536 549 |
| CENSORED DEATHS |
| 126 354 420 421 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 40MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 42 CENSORED DEATHS 1 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 121 290 292 304 332 397 420 438 442 442 |
| 443 447 449 463 470 470 475 482 486 486 |
| 486 486 490 493 493 497 503 503 508 512 |
| 514 514 524 526 528 528 542 545 545 547 |
| 549 549 |
| CENSORED DEATHS |
| 53 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 121 293 325 362 383 421 423 435 437 442 |
| 450 452 454 458 464 475 493 500 510 510 |
| 510 512 512 514 517 518 519 520 531 533 |
| 536 545 547 550 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 552 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 160MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 33 CENSORED DEATHS 3 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 195 268 317 385 395 412 427 437 441 442 |
| 445 447 463 474 478 478 480 482 484 484 |
| 486 486 487 493 504 507 509 513 514 517 |
| 528 528 542 |
| CENSORED DEATHS |
| 400 420 471 |
| |
==================================================================================
P-NITROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 552 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 552 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0MG/KG | 100.0 100.0 98.3 98.3 89.6 86.0 53.8 52.0 52.0 52.0 |
| | |
| | |
|40MG/KG | 100.0 98.3 98.3 91.5 88.1 69.5 33.9 28.8 28.8 28.8 |
| | |
| | |
|80MG/KG | 100.0 98.3 98.3 93.3 88.3 73.3 46.7 43.3 43.3 43.3 |
| | |
| | |
|160MG/KG | 100.0 100.0 96.7 95.0 90.0 65.5 42.5 42.5 42.5 42.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.0% 28.8% 43.3% 42.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.498 P=0.013 P=0.387 P=0.186 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 480.5 465.0 463.9 456.0 |
|NATURAL DEATHS (C) | (12.8) (13.3) (15.0) (13.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 505.0 482.8 502.1 493.1 |
|(STANDARD ERROR) | (10.3) (12.8) (10.2) ( 9.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 552 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 120 295 370 373 438 442 447 448 450 463 |
| 472 475 475 483 485 493 493 497 505 510 |
| 511 512 512 520 528 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 40MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 263 266 361 367 375 440 442 449 450 450 |
| 456 473 477 478 482 482 486 492 497 497 |
| 497 497 497 498 500 500 514 527 529 530 |
| 532 542 545 549 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 349 401 427 442 442 446 458 458 463 464 |
| 470 475 477 493 503 504 507 507 510 510 |
| 521 532 532 538 545 545 548 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
P-NITROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 552 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 160MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 32 CENSORED DEATHS 1 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 84 405 411 443 454 458 463 468 470 473 |
| 475 475 475 480 486 492 497 500 506 507 |
| 508 509 517 521 524 531 531 532 532 542 |
| 545 546 |
| CENSORED DEATHS |
| 371 |
| |
==================================================================================
P-NITROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 552 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 552 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0MG/KG | 100.0 98.3 98.3 96.7 93.3 75.0 58.3 58.3 58.3 58.3 |
| | |
| | |
|40MG/KG | 100.0 100.0 96.7 95.0 91.7 73.3 45.0 43.3 43.3 43.3 |
| | |
| | |
|80MG/KG | 100.0 100.0 100.0 98.3 96.7 78.3 56.7 55.0 55.0 55.0 |
| | |
| | |
|160MG/KG | 98.3 98.3 98.3 98.3 94.9 76.3 47.5 45.8 45.8 45.8 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0MG/KG 40MG/KG 80MG/KG 160MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 58.3% 43.3% 55.0% 45.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.614 P=0.203 P=0.990 P=0.386 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 452.7 468.8 484.0 480.0 |
|NATURAL DEATHS (C) | (17.5) (11.9) ( 9.2) (14.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 510.6 504.9 521.4 510.6 |
|(STANDARD ERROR) | ( 9.6) ( 8.6) ( 6.0) ( 9.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
P-NITROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0MG/KG = 1
40MG/KG = 2
80MG/KG = 3
160MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 4 1
| 2 4 1 4 2 43 1 1
| 2 2 43 3 4
| 2 2 3 3 2 111
90 + 2 421 1
| 23 22 1 1
| 33
| 3 3
P 80 + 2 2 4 11
E | 2322 1 1
R | 33 4
C | 3 3 3
E 70 + 2 22 311
N |
T | 31 1
|
S 60 + 22 11
U | 4 443 3
R | 2 2 11 1
V | 224 333 1
I 50 + 22
V | 4 433 3
A | 2 22 4
L | 4 3
40 + 2 2
|
| 2 2
|
30 + 2
|
|
|
20 +
|
---+------------+------------+------------+------------+------------+------------+------------+------------+--
0 10 20 30 40 50 60 70 80
WEEK
NOTE: 48 obs hidden.
P-NITROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0MG/KG = 1
40MG/KG = 2
80MG/KG = 3
160MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 1 2 3
| 4 1 2 1 3 21 3 4 3
| 211 4 3 3
| 21 11 44
P 90 + 22 34
E | 1 1334
R | 1 1
C | 2211
E 80 + 2 2
N | 1 113 3
T | 11
| 222 33
S 70 + 1 41
U | 3 3
R | 11 33
V | 2 241 133
I 60 + 4 1133
V | 2 2 41 3 1
A | 2 2 3
L |
50 + 4 4
| 2 2
| 2 2
| 2
40 +
|
---+------------+------------+------------+------------+------------+------------+------------+------------+--
0 10 20 30 40 50 60 70 80
WEEK
NOTE: 45 obs hidden.