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TDMS Study 05099-08 Pathology Tables

NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96
Route: GAVAGE                                                                                                     Time: 20:30:27




       Facility:  Southern Research Institute

       Chemical CAS #:  599-79-1

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      675          1350         2700                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Accidently Killed                                  1                         1                                                  
    Moribund Sacrifice                                 5            6            8            6                                     
    Natural Death                                      2            3            4            4                                     
    Dosing Accident                                    1                                      2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           41           36           38                                     
    Accidently Killed                                                            1                                                  

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (59)         (60)         (59)         (56)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Large, Cecum                             (59)         (59)         (58)         (56)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Jejunum                           (59)         (59)         (58)         (56)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Intestine Small, Ileum                             (59)         (59)         (58)         (55)                                   
   Liver                                              (60)         (60)         (60)         (59)                                   
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  2 (3%)       1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (5%)       8 (13%)      9 (15%)      9 (15%)                               
      Hepatocellular Carcinoma, Multiple                            2 (3%)       1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                          10 (17%)     16 (27%)     14 (23%)     16 (27%)                               
      Hepatocellular Adenoma, Multiple                 3 (5%)      12 (20%)     12 (20%)     14 (24%)                               
      Histiocytic Sarcoma                              1 (2%)                    2 (3%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Mesentery                                          (7)          (11)         (3)          (5)                                    
      Histiocytic Sarcoma                                                        1 (33%)                                            
      Leiomyosarcoma, Metastatic, Uterus                                         1 (33%)                                            
   Pancreas                                           (60)         (59)         (60)         (59)                                   
      Hemangioma                                                                 1 (2%)                                             
   Salivary Glands                                    (59)         (60)         (60)         (60)                                   
   Stomach, Forestomach                               (60)         (59)         (60)         (59)                                   
      Squamous Cell Papilloma                          5 (8%)       2 (3%)       1 (2%)                                             
   Stomach, Glandular                                 (60)         (59)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      675          1350         2700                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                       1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Rectum                                                                             1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                          1 (2%)       2 (3%)                    1 (2%)                                
   Pituitary Gland                                    (59)         (55)         (60)         (56)                                   
      Pars Distalis, Adenoma                           7 (12%)      7 (13%)      7 (12%)      2 (4%)                                
      Pars Intermedia, Adenoma                         1 (2%)                                 2 (4%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)                    2 (3%)       1 (2%)                                
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (59)         (59)         (59)                                   
      Cystadenoma                                      2 (3%)       5 (8%)       5 (8%)       2 (3%)                                
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Uterus                                         1 (2%)                                             
      Luteoma                                                       1 (2%)       3 (5%)       1 (2%)                                
      Teratoma Malignant                                                         1 (2%)                                             
      Thecoma Malignant                                             1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                    3 (5%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      675          1350         2700                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (8)          (7)          (11)         (4)                                    
      Iliac, Histiocytic Sarcoma                       1 (13%)                                                                      
      Inguinal, Histiocytic Sarcoma                                              1 (9%)                                             
      Inguinal, Mast Cell Tumor NOS                                              1 (9%)                                             
      Mediastinal, Histiocytic Sarcoma                 1 (13%)                                                                      
      Renal, Histiocytic Sarcoma                       1 (13%)                                                                      
      Renal, Teratoma Malignant, Metastatic, Ovary                               1 (9%)                                             
   Lymph Node, Mandibular                             (59)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (58)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (60)         (60)         (60)         (59)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               2 (3%)       4 (7%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (60)         (59)         (59)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenoacanthoma                                                             1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Skin                                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                                                 2 (3%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Cranium, Osteosarcoma                                                                   1 (2%)                                
      Vertebra, Osteosarcoma                                        1 (2%)                                                          
   Skeletal Muscle                                    (1)                       (2)          (1)                                    
      Fibrosarcoma                                                               1 (50%)                                            
      Leiomyosarcoma, Metastatic, Uterus                                         1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      675          1350         2700                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Spinal Cord                                        (2)          (1)                       (2)                                    
      Osteosarcoma, Metastatic, Bone                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Adenoacanthoma, Metastatic, Mammary Gland                                  1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     3 (5%)       3 (5%)       3 (5%)       4 (7%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                    1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Leiomyosarcoma, Metastatic, Uterus                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (2)                       (1)          (2)                                    
      Adenoma                                          2 (100%)                  1 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              2 (3%)                    4 (7%)                                             
      Lymphoma Malignant                              13 (22%)      6 (10%)      7 (12%)      6 (10%)                               
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      675          1350         2700                                      
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          38          43          38                                       
     Total Primary Neoplasms                           61          73          85          70                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          33          35          34                                       
     Total Benign Neoplasms                            38          49          50          48                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          19          26          18                                       
     Total Malignant Neoplasms                         23          24          34          22                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           3           2                                       
     Total Metastatic Neoplasm                          2           4           6           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      675          1350         2700                         
                                                                FEED RTD     MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60           60                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 5            3            4            3            4                        
    Natural Death                                      3            1            5            6                                     
    Dosing Accident                                    2            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           45           41           41           46                        

  Animals Examined Microscopically                    60           60           60           60           60                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (58)         (60)         (57)         (57)         (60)                      
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Large, Cecum                             (57)         (60)         (56)         (56)         (60)                      
      Adenocarcinoma                                                                                       1 (2%)                   
   Intestine Small, Jejunum                           (57)         (60)         (56)         (57)         (60)                      
      Adenocarcinoma                                                                          1 (2%)                                
   Intestine Small, Ileum                             (57)         (60)         (56)         (56)         (60)                      
   Liver                                              (60)         (60)         (60)         (60)         (60)                      
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  2 (3%)                                                                       
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                        12 (20%)      6 (10%)     11 (18%)     19 (32%)      8 (13%)                  
      Hepatocellular Carcinoma, Multiple               1 (2%)                    4 (7%)       5 (8%)                                
      Hepatocellular Adenoma                          14 (23%)      9 (15%)     13 (22%)     13 (22%)     17 (28%)                  
      Hepatocellular Adenoma, Multiple                 1 (2%)                   21 (35%)     15 (25%)     27 (45%)                  
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Mesentery                                          (4)          (2)          (4)          (1)          (1)                       
   Pancreas                                           (60)         (60)         (60)         (60)         (60)                      
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Acinus, Adenoma                                  1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (59)         (60)                      
      Squamous Cell Papilloma                          4 (7%)       5 (8%)                    1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (58)         (60)                      
      Adenoma                                                                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      675          1350         2700                         
                                                                FEED RTD     MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)         (60)         (60)         (60)                      
      Aorta, Alveolar/Bronchiolar Carcinoma,                                                                                        
          Metastatic, Lung                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (59)         (59)         (60)                      
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
      Capsule, Adenoma                                 1 (2%)                                 2 (3%)                                
   Adrenal Medulla                                    (60)         (60)         (59)         (59)         (60)                      
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)         (60)                      
      Adenoma                                          1 (2%)                                              1 (2%)                   
   Pituitary Gland                                    (54)         (56)         (56)         (57)         (57)                      
      Pars Distalis, Adenoma                           1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
      Pars Intermedia, Carcinoma                       1 (2%)                                                                       
   Thyroid Gland                                      (60)         (60)         (60)         (60)         (60)                      
      Follicular Cell, Adenoma                         1 (2%)       2 (3%)                                 1 (2%)                   
      Follicular Cell, Carcinoma                                                                           1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)         (60)                      
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Preputial Gland                                    (59)         (60)         (59)         (59)         (60)                      
      Adenoma                                                                                              1 (2%)                   
   Prostate                                           (60)         (60)         (60)         (60)         (60)                      
   Seminal Vesicle                                    (60)         (60)         (60)         (60)         (60)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)         (60)                      
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (3)          (1)          (3)          (3)          (4)                       
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                   1 (33%)                               
      Mediastinal, Histiocytic Sarcoma                                                        1 (33%)                               

                                                             Page   8                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      675          1350         2700                         
                                                                FEED RTD     MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Pancreatic, Histiocytic Sarcoma                                                         1 (33%)                               
   Lymph Node, Mandibular                             (60)         (59)         (59)         (59)         (59)                      
   Lymph Node, Mesenteric                             (60)         (58)         (60)         (60)         (60)                      
      Hemangiosarcoma                                                                                      1 (2%)                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Spleen                                             (60)         (60)         (60)         (59)         (60)                      
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                 1 (2%)                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Thymus                                             (54)         (56)         (53)         (56)         (56)                      
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)         (60)                      
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                                  1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                                                                    1 (2%)                                
      Subcutaneous Tissue, Plasma Cell Tumor Benign                                                        1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)         (60)                      
      Vertebra, Osteosarcoma                                                                  1 (2%)                                
   Skeletal Muscle                                                 (1)                                                              
      Hemangiosarcoma                                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)         (60)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)         (60)                      
      Alveolar/Bronchiolar Adenoma                    10 (17%)      6 (10%)     10 (17%)     13 (22%)      4 (7%)                   
      Alveolar/Bronchiolar Adenoma, Multiple           2 (3%)                                 3 (5%)       2 (3%)                   
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       4 (7%)       8 (13%)      3 (5%)       4 (7%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (2%)                   
      Carcinoma, Metastatic, Tissue NOS                                                                    1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      4 (7%)       1 (2%)       2 (3%)                                             
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Alveolar Epithelium, Alveolar/Bronchiolar                                                                                     

                                                             Page   9                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      675          1350         2700                         
                                                                FEED RTD     MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
          Adenoma                                                                1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (5)          (1)          (2)                       
      Adenoma                                          2 (67%)                   4 (80%)      1 (100%)     2 (100%)                 
      Carcinoma                                        1 (33%)      2 (67%)                                                         
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)         (60)                      
   Urinary Bladder                                    (60)         (60)         (60)         (60)         (60)                      
      Hemangioma                                                                                           1 (2%)                   
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)        *(60)                      
      Histiocytic Sarcoma                                                                     2 (3%)                                
      Lymphoma Malignant                               5 (8%)       2 (3%)       3 (5%)       1 (2%)       1 (2%)                   
      Lymphoma Malignant Lymphocytic                                                                       1 (2%)                   
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05099-08  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 20:30:27  
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         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      675          1350         2700                         
                                                                FEED RTD     MG/KG        MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          31          47          44          47                           
     Total Primary Neoplasms                           66          39          79          81          77                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          20          38          34          45                           
     Total Benign Neoplasms                            39          22          50          48          58                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          16          26          30          14                           
     Total Malignant Neoplasms                         27          17          29          33          19                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           1           2           2           1                           
     Total Metastatic Neoplasm                          8           1           2           5           1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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