TDMS Study 05099-08 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst SALICYLAZOSULFAPYRIDINE DATE: 04/03/96
EXPERIMENT: 05099 TEST: 08 TIME: 20:35:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85233 ROUTE: GAVAGE NTP C#: 61552B
PATHOLOGIST: R.B. THOMPSON CAS: 599-79-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst SALICYLAZOSULFAPYRIDINE DATE: 04/03/96
EXPERIMENT: 05099 TEST: 08 TIME: 20:35:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85233 ROUTE: GAVAGE NTP C#: 61552B
PATHOLOGIST: R.B. THOMPSON CAS: 599-79-1
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst SALICYLAZOSULFAPYRIDINE DATE: 04/03/96
EXPERIMENT: 05099 TEST: 08 TIME: 20:35:39
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85233 ROUTE: GAVAGE NTP C#: 61552B
PATHOLOGIST: R.B. THOMPSON CAS: 599-79-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF SALICYLAZOSULFAPYRIDINE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Stomach, Forestomach Squamous Cell Papilloma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Skin Squamous Cell Papilloma
Stomach, Forestomach Squamous Cell Papilloma
All Organs Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
Cell Type
Benign Tumors
====================================================================================================
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/120 (1%) 0/59 (0%) 2/59 (3%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 1.2% 0.0% 5.0% 0.0% | 0.0% 2.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/85 (1%) 0/40 (0%) 2/40 (5%) 0/46 (0%) | 0/41 (0%) 1/41 (2%) 0/37 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- 728 (T) --- | --- 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.601N P=0.650N P=0.250 P=0.622N | P=0.580N P=0.500 (e) (e) |
|INCIDENTAL TUMOR | P=0.601N P=0.650N P=0.250 P=0.622N | P=0.580N P=0.500 (e) (e) |
|LOGISTIC REGRESSION | P=0.601N P=0.650N P=0.250 P=0.622N | P=0.580N P=0.500 (e) (e) |
|COCHRAN-ARMITAGE | P=0.622N | P=0.567N |
|FISHER EXACT | P=0.670N P=0.253 P=0.667N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/120 (0%) 0/59 (0%) 0/59 (0%) 0/60 (0%) | 1/60 (2%) 2/60 (3%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 4.7% 0.0% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/85 (0%) 0/40 (0%) 0/40 (0%) 0/46 (0%) | 1/41 (2%) 1/41 (2%) 0/37 (0%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 735 (T) 620 --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.522N P=0.503 P=0.520N P=0.745 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.427N P=0.578 P=0.520N P=0.745 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.510N P=0.505 P=0.520N P=0.745 |
|COCHRAN-ARMITAGE | (e) | P=0.500N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.500N P=0.752N |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/120 (2%) 4/60 (7%) 1/60 (2%) 2/60 (3%) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 2.4% 9.8% 2.4% 4.3% | 4.9% 0.0% 2.7% 5.3% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/85 (2%) 4/41 (10%) 1/41 (2%) 2/46 (4%) | 2/41 (5%) 0/41 (0%) 1/37 (3%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 728 (T) 728 (T) 728 (T) | 735 (T) --- 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.498 P=0.084 P=0.723 P=0.460 | P=0.439 P=0.238N P=0.536N P=0.667 |
|INCIDENTAL TUMOR | P=0.498 P=0.084 P=0.723 P=0.460 | P=0.439 P=0.238N P=0.536N P=0.667 |
|LOGISTIC REGRESSION | P=0.498 P=0.084 P=0.723 P=0.460 | P=0.439 P=0.238N P=0.536N P=0.667 |
|COCHRAN-ARMITAGE | P=0.464 | P=0.469 |
|FISHER EXACT | P=0.096 P=0.742N P=0.407 | P=0.248N P=0.500N P=0.691N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/120 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 3.5% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/85 (4%) 0/41 (0%) 0/41 (0%) 0/46 (0%) | 0/41 (0%) 0/41 (0%) 0/37 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.104N P=0.277N P=0.277N P=0.250N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.104N P=0.277N P=0.277N P=0.250N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.104N P=0.277N P=0.277N P=0.250N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.107N | (e) |
|FISHER EXACT | P=0.294N P=0.294N P=0.294N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/120 (4%) 4/60 (7%) 1/60 (2%) 2/60 (3%) | 2/60 (3%) 0/60 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 5.9% 9.8% 2.4% 4.3% | 4.9% 0.0% 2.7% 5.3% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/85 (6%) 4/41 (10%) 1/41 (2%) 2/46 (4%) | 2/41 (5%) 0/41 (0%) 1/37 (3%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | 728 (T) 728 (T) 728 (T) 728 (T) | 735 (T) --- 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.328N P=0.337 P=0.344N P=0.514N | P=0.439 P=0.238N P=0.536N P=0.667 |
|INCIDENTAL TUMOR | P=0.328N P=0.337 P=0.344N P=0.514N | P=0.439 P=0.238N P=0.536N P=0.667 |
|LOGISTIC REGRESSION | P=0.328N P=0.337 P=0.344N P=0.514N | P=0.439 P=0.238N P=0.536N P=0.667 |
|COCHRAN-ARMITAGE | P=0.361N | P=0.469 |
|FISHER EXACT | P=0.347 P=0.347N P=0.571N | P=0.248N P=0.500N P=0.691N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/120 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 2.4% 0.0% 0.0% 0.0% | 4.9% 2.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/85 (2%) 0/41 (0%) 0/41 (0%) 0/46 (0%) | 2/41 (5%) 1/41 (2%) 0/37 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- --- | 735 (T) 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.192N P=0.410N P=0.410N P=0.382N | P=0.111N P=0.500N P=0.261N P=0.255N |
|INCIDENTAL TUMOR | P=0.192N P=0.410N P=0.410N P=0.382N | P=0.111N P=0.500N P=0.261N P=0.255N |
|LOGISTIC REGRESSION | P=0.192N P=0.410N P=0.410N P=0.382N | P=0.111N P=0.500N P=0.261N P=0.255N |
|COCHRAN-ARMITAGE | P=0.197N | P=0.102N |
|FISHER EXACT | P=0.443N P=0.443N P=0.443N | P=0.500N P=0.248N P=0.252N |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/120 (20%) 34/60 (57%) 28/60 (47%) 44/60 (73%) | 13/60 (22%) 28/60 (47%) 26/60 (43%) 30/59 (51%) |
|ADJUSTED (b) | 26.7% 77.0% 66.6% 87.9% | 30.5% 63.6% 66.3% 72.8% |
|INTERIM SACRIFICE 1 (c)| 3/20 (15%) 2/10 (20%) 0/10 (0%) 2/10 (20%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 2/10 (20%) |
|TERMINAL (d) | 21/85 (25%) 31/41 (76%) 27/41 (66%) 40/46 (87%) | 12/41 (29%) 25/41 (61%) 24/37 (65%) 27/38 (71%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 678 456 (I) | 457 (I) 539 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.002 ** P=0.002 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.003 ** P=0.002 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.001 ** P=0.002 ** P=0.005 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.004 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.003 ** P=0.009 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/120 (16%) 15/60 (25%) 24/60 (40%) 8/60 (13%) | 3/60 (5%) 10/60 (17%) 10/60 (17%) 10/59 (17%) |
|ADJUSTED (b) | 20.8% 33.8% 51.8% 17.4% | 6.6% 23.7% 27.0% 25.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 14/85 (16%) 12/41 (29%) 19/41 (46%) 8/46 (17%) | 2/41 (5%) 9/41 (22%) 10/37 (27%) 9/38 (24%) |
|FIRST INCIDENCE (DAYS) | 420 567 456 (I) 728 (T) | 457 (I) 551 735 (T) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529 P=0.090 P<0.001 ** P=0.346N | P=0.050 P=0.040 * P=0.024 * P=0.029 * |
|INCIDENTAL TUMOR | P=0.335 P=0.089 P<0.001 ** P=0.508N | P=0.060 P=0.048 * P=0.024 * P=0.029 * |
|LOGISTIC REGRESSION | P=0.369 P=0.111 P<0.001 ** P=0.396N | P=0.061 P=0.040 * P=0.033 * P=0.035 * |
|COCHRAN-ARMITAGE | P=0.441 | P=0.071 |
|FISHER EXACT | P=0.102 P<0.001 ** P=0.419N | P=0.037 * P=0.037 * P=0.035 * |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/120 (16%) 15/60 (25%) 24/60 (40%) 8/60 (13%) | 3/60 (5%) 10/60 (17%) 10/60 (17%) 10/59 (17%) |
|ADJUSTED (b) | 20.8% 33.8% 51.8% 17.4% | 6.6% 23.7% 27.0% 25.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 14/85 (16%) 12/41 (29%) 19/41 (46%) 8/46 (17%) | 2/41 (5%) 9/41 (22%) 10/37 (27%) 9/38 (24%) |
|FIRST INCIDENCE (DAYS) | 420 567 456 (I) 728 (T) | 457 (I) 551 735 (T) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529 P=0.090 P<0.001 ** P=0.346N | P=0.050 P=0.040 * P=0.024 * P=0.029 * |
|INCIDENTAL TUMOR | P=0.335 P=0.089 P<0.001 ** P=0.508N | P=0.060 P=0.048 * P=0.024 * P=0.029 * |
|LOGISTIC REGRESSION | P=0.369 P=0.111 P<0.001 ** P=0.396N | P=0.061 P=0.040 * P=0.033 * P=0.035 * |
|COCHRAN-ARMITAGE | P=0.441 | P=0.071 |
|FISHER EXACT | P=0.102 P<0.001 ** P=0.419N | P=0.037 * P=0.037 * P=0.035 * |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 41/120 (34%) 40/60 (67%) 39/60 (65%) 46/60 (77%) | 15/60 (25%) 32/60 (53%) 29/60 (48%) 31/59 (53%) |
|ADJUSTED (b) | 43.5% 84.9% 82.9% 92.0% | 35.3% 71.1% 74.1% 75.2% |
|INTERIM SACRIFICE 1 (c)| 3/20 (15%) 2/10 (20%) 1/10 (10%) 2/10 (20%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 2/10 (20%) |
|TERMINAL (d) | 33/85 (39%) 34/41 (83%) 33/41 (80%) 42/46 (91%) | 14/41 (34%) 28/41 (68%) 27/37 (73%) 28/38 (74%) |
|FIRST INCIDENCE (DAYS) | 420 456 (I) 456 (I) 456 (I) | 457 (I) 539 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.002 ** P=0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.003 ** P<0.001 ** P=0.003 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.009 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.001 ** P=0.007 ** P=0.002 ** |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 41/120 (34%) 40/60 (67%) 39/60 (65%) 46/60 (77%) | 15/60 (25%) 32/60 (53%) 29/60 (48%) 31/59 (53%) |
|ADJUSTED (b) | 43.5% 84.9% 82.9% 92.0% | 35.3% 71.1% 74.1% 75.2% |
|INTERIM SACRIFICE 1 (c)| 3/20 (15%) 2/10 (20%) 1/10 (10%) 2/10 (20%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 2/10 (20%) |
|TERMINAL (d) | 33/85 (39%) 34/41 (83%) 33/41 (80%) 42/46 (91%) | 14/41 (34%) 28/41 (68%) 27/37 (73%) 28/38 (74%) |
|FIRST INCIDENCE (DAYS) | 420 456 (I) 456 (I) 456 (I) | 457 (I) 539 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.002 ** P=0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.003 ** P<0.001 ** P=0.003 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.009 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.001 ** P=0.007 ** P=0.002 ** |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/120 (15%) 11/60 (18%) 16/60 (27%) 6/60 (10%) | 3/60 (5%) 3/60 (5%) 3/60 (5%) 4/60 (7%) |
|ADJUSTED (b) | 20.1% 26.8% 35.5% 13.0% | 6.6% 7.0% 8.1% 10.5% |
|INTERIM SACRIFICE 1 (c)| 1/20 (5%) 0/10 (0%) 2/10 (20%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 15/85 (18%) 11/41 (27%) 13/41 (32%) 6/46 (13%) | 2/41 (5%) 2/41 (5%) 3/37 (8%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 728 (T) 456 (I) 728 (T) | 457 (I) 620 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296N P=0.324 P=0.038 * P=0.194N | P=0.363 P=0.659N P=0.622 P=0.465 |
|INCIDENTAL TUMOR | P=0.364N P=0.324 P=0.030 * P=0.280N | P=0.416 P=0.610N P=0.622 P=0.465 |
|LOGISTIC REGRESSION | P=0.339N P=0.351 P=0.048 * P=0.227N | P=0.387 P=0.658N P=0.658 P=0.489 |
|COCHRAN-ARMITAGE | P=0.363N | P=0.405 |
|FISHER EXACT | P=0.355 P=0.048 * P=0.246N | P=0.660N P=0.660N P=0.500 |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/120 (6%) 8/60 (13%) 3/60 (5%) 5/60 (8%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 8.1% 18.4% 6.5% 10.9% | 2.4% 2.4% 2.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/85 (7%) 6/41 (15%) 2/41 (5%) 5/46 (11%) | 1/41 (2%) 1/41 (2%) 1/37 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 689 588 456 (I) 728 (T) | 735 (T) 735 (T) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.504 P=0.069 P=0.565N P=0.428 | P=0.332N P=0.762 P=0.739 P=0.515N |
|INCIDENTAL TUMOR | P=0.433 P=0.098 P=0.502N P=0.390 | P=0.332N P=0.762 P=0.739 P=0.515N |
|LOGISTIC REGRESSION | P=0.471 P=0.072 P=0.541N P=0.410 | P=0.332N P=0.762 P=0.739 P=0.515N |
|COCHRAN-ARMITAGE | P=0.454 | P=0.312N |
|FISHER EXACT | P=0.079 P=0.559N P=0.366 | P=0.752N P=0.752N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 24/120 (20%) 18/60 (30%) 17/60 (28%) 11/60 (18%) | 4/60 (7%) 4/60 (7%) 4/60 (7%) 4/60 (7%) |
|ADJUSTED (b) | 26.7% 41.7% 37.8% 23.9% | 9.0% 9.4% 10.8% 10.5% |
|INTERIM SACRIFICE 1 (c)| 1/20 (5%) 0/10 (0%) 2/10 (20%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 20/85 (24%) 16/41 (39%) 14/41 (34%) 11/46 (24%) | 3/41 (7%) 3/41 (7%) 4/37 (11%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 588 456 (I) 728 (T) | 457 (I) 620 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372N P=0.076 P=0.120 P=0.386N | P=0.520 P=0.640N P=0.593 P=0.606 |
|INCIDENTAL TUMOR | P=0.482N P=0.093 P=0.121 P=0.513N | P=0.569N P=0.596N P=0.593 P=0.606 |
|LOGISTIC REGRESSION | P=0.429N P=0.085 P=0.146 P=0.442N | P=0.548 P=0.635N P=0.636 P=0.631 |
|COCHRAN-ARMITAGE | P=0.464N | P=0.569 |
|FISHER EXACT | P=0.096 P=0.143 P=0.479N | P=0.641N P=0.641N P=0.641N |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/59 (3%) 5/59 (8%) 5/59 (8%) 2/59 (3%) |
|ADJUSTED (b) | | 4.2% 12.5% 13.1% 5.3% |
|INTERIM SACRIFICE 1 (c)| | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/40 (3%) 5/40 (13%) 4/36 (11%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | | 457 (I) 735 (T) 618 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.496N P=0.218 P=0.193 P=0.679 |
|INCIDENTAL TUMOR | | P=0.443N P=0.218 P=0.226 P=0.679 |
|LOGISTIC REGRESSION | | P=0.470N P=0.223 P=0.215 P=0.694 |
|COCHRAN-ARMITAGE | | P=0.463N |
|FISHER EXACT | | P=0.219 P=0.219 P=0.691N |
|=================================================================================================================================|
| |
|Ovary |
| Luteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/59 (0%) 1/59 (2%) 3/59 (5%) 1/59 (2%) |
|ADJUSTED (b) | | 0.0% 2.5% 8.3% 2.6% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/40 (0%) 1/40 (3%) 3/36 (8%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 735 (T) 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.331 P=0.500 P=0.103 P=0.490 |
|INCIDENTAL TUMOR | | P=0.331 P=0.500 P=0.103 P=0.490 |
|LOGISTIC REGRESSION | | P=0.331 P=0.500 P=0.103 P=0.490 |
|COCHRAN-ARMITAGE | | P=0.351 |
|FISHER EXACT | | P=0.500 P=0.122 P=0.500 |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/110 (1%) 0/56 (0%) 0/57 (0%) 0/57 (0%) | 7/59 (12%) 7/55 (13%) 7/60 (12%) 2/56 (4%) |
|ADJUSTED (b) | 1.3% 0.0% 0.0% 0.0% | 17.5% 17.5% 17.8% 5.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/76 (1%) 0/40 (0%) 0/39 (0%) 0/44 (0%) | 7/40 (18%) 7/40 (18%) 5/37 (14%) 1/35 (3%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- --- | 735 (T) 735 (T) 663 603 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.378N P=0.628N P=0.633N P=0.609N | P=0.097N P=0.615 P=0.553 P=0.112N |
|INCIDENTAL TUMOR | P=0.378N P=0.628N P=0.633N P=0.609N | P=0.056N P=0.615 P=0.555N P=0.080N |
|LOGISTIC REGRESSION | P=0.378N P=0.628N P=0.633N P=0.609N | P=0.084N P=0.615 P=0.594 P=0.104N |
|COCHRAN-ARMITAGE | P=0.389N | P=0.070N |
|FISHER EXACT | P=0.663N P=0.659N P=0.659N | P=0.556 P=0.598N P=0.094N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/110 (0%) 1/56 (2%) 0/57 (0%) 0/57 (0%) | 1/59 (2%) 0/55 (0%) 0/60 (0%) 2/56 (4%) |
|ADJUSTED (b) | 0.0% 2.5% 0.0% 0.0% | 2.5% 0.0% 0.0% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/76 (0%) 1/40 (3%) 0/39 (0%) 0/44 (0%) | 1/40 (3%) 0/40 (0%) 0/37 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | --- 728 (T) --- --- | 735 (T) --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.634N P=0.372 (e) (e) | P=0.214 P=0.500N P=0.516N P=0.453 |
|INCIDENTAL TUMOR | P=0.634N P=0.372 (e) (e) | P=0.214 P=0.500N P=0.516N P=0.453 |
|LOGISTIC REGRESSION | P=0.634N P=0.372 (e) (e) | P=0.214 P=0.500N P=0.516N P=0.453 |
|COCHRAN-ARMITAGE | P=0.650N | P=0.239 |
|FISHER EXACT | P=0.337 (e) (e) | P=0.518N P=0.496N P=0.480 |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/110 (1%) 1/56 (2%) 0/57 (0%) 0/57 (0%) | 1/59 (2%) 0/55 (0%) 0/60 (0%) 2/56 (4%) |
|ADJUSTED (b) | 1.1% 2.5% 0.0% 0.0% | 2.5% 0.0% 0.0% 5.7% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/76 (0%) 1/40 (3%) 0/39 (0%) 0/44 (0%) | 1/40 (3%) 0/40 (0%) 0/37 (0%) 2/35 (6%) |
|FIRST INCIDENCE (DAYS) | 610 728 (T) --- --- | 735 (T) --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.340N P=0.604 P=0.636N P=0.636N | P=0.214 P=0.500N P=0.516N P=0.453 |
|INCIDENTAL TUMOR | P=0.505N P=0.605 P=0.846N (e) | P=0.214 P=0.500N P=0.516N P=0.453 |
|LOGISTIC REGRESSION | P=0.345N P=0.605 P=0.637N P=0.626N | P=0.214 P=0.500N P=0.516N P=0.453 |
|COCHRAN-ARMITAGE | P=0.345N | P=0.239 |
|FISHER EXACT | P=0.562 P=0.659N P=0.659N | P=0.518N P=0.496N P=0.480 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/120 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 5.3% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/85 (0%) 0/41 (0%) 0/41 (0%) 0/46 (0%) | 0/41 (0%) 0/41 (0%) 0/37 (0%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.042 * (e) (e) P=0.222 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.042 * (e) (e) P=0.222 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.042 * (e) (e) P=0.222 |
|COCHRAN-ARMITAGE | (e) | P=0.046 * |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.248 |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/120 (2%) 0/60 (0%) 0/59 (0%) 1/60 (2%) | 0/60 (0%) 2/60 (3%) 4/60 (7%) 1/59 (2%) |
|ADJUSTED (b) | 2.2% 0.0% 0.0% 2.2% | 0.0% 4.7% 10.3% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/85 (1%) 0/41 (0%) 0/41 (0%) 1/46 (2%) | 0/41 (0%) 1/41 (2%) 3/37 (8%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 601 --- --- 728 (T) | --- 620 661 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.607N P=0.408N P=0.406N P=0.714N | P=0.391 P=0.242 P=0.055 P=0.485 |
|INCIDENTAL TUMOR | P=0.567 P=0.406N P=0.522N P=0.618 | P=0.509 P=0.314 P=0.083 P=0.485 |
|LOGISTIC REGRESSION | P=0.621N P=0.401N P=0.404N P=0.730N | P=0.408 P=0.241 P=0.059 P=0.485 |
|COCHRAN-ARMITAGE | P=0.623N | P=0.416 |
|FISHER EXACT | P=0.443N P=0.448N P=0.742N | P=0.248 P=0.059 P=0.496 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 9/120 (8%) 0/60 (0%) 1/60 (2%) 0/60 (0%) | 5/60 (8%) 2/60 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 10.0% 0.0% 2.4% 0.0% | 12.2% 4.1% 2.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/20 (5%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/85 (8%) 0/41 (0%) 1/41 (2%) 0/46 (0%) | 5/41 (12%) 1/41 (2%) 1/37 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 456 (I) --- 728 (T) --- | 735 (T) 457 (I) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009N** P=0.038N* P=0.111N P=0.031N* | P=0.018N* P=0.219N P=0.128N P=0.040N* |
|INCIDENTAL TUMOR | P=0.011N* P=0.038N* P=0.132N P=0.041N* | P=0.018N* P=0.219N P=0.128N P=0.040N* |
|LOGISTIC REGRESSION | P=0.009N** P=0.035N* P=0.101N P=0.034N* | P=0.015N* P=0.211N P=0.128N P=0.040N* |
|COCHRAN-ARMITAGE | P=0.009N** | P=0.014N* |
|FISHER EXACT | P=0.023N* P=0.097N P=0.023N* | P=0.219N P=0.103N P=0.029N* |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/120 (3%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 3.5% 0.0% 0.0% 2.2% | 2.4% 0.0% 5.1% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/85 (4%) 0/41 (0%) 0/41 (0%) 1/46 (2%) | 1/41 (2%) 0/41 (0%) 1/37 (3%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- 728 (T) | 735 (T) --- 686 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.401N P=0.277N P=0.277N P=0.540N | P=0.472 P=0.500N P=0.468 P=0.745 |
|INCIDENTAL TUMOR | P=0.401N P=0.277N P=0.277N P=0.540N | P=0.534 P=0.500N P=0.595 P=0.745 |
|LOGISTIC REGRESSION | P=0.401N P=0.277N P=0.277N P=0.540N | P=0.485 P=0.500N P=0.490 P=0.745 |
|COCHRAN-ARMITAGE | P=0.420N | P=0.500 |
|FISHER EXACT | P=0.294N P=0.294N P=0.593N | P=0.500N P=0.500 P=0.752N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/120 (3%) 0/60 (0%) 0/60 (0%) 2/60 (3%) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 3.5% 0.0% 0.0% 4.3% | 2.4% 0.0% 5.1% 5.3% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/85 (4%) 0/41 (0%) 0/41 (0%) 2/46 (4%) | 1/41 (2%) 0/41 (0%) 1/37 (3%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- 728 (T) | 735 (T) --- 686 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.524 P=0.277N P=0.277N P=0.596 | P=0.222 P=0.500N P=0.468 P=0.473 |
|INCIDENTAL TUMOR | P=0.524 P=0.277N P=0.277N P=0.596 | P=0.262 P=0.500N P=0.595 P=0.473 |
|LOGISTIC REGRESSION | P=0.524 P=0.277N P=0.277N P=0.596 | P=0.230 P=0.500N P=0.490 P=0.473 |
|COCHRAN-ARMITAGE | P=0.500 | P=0.246 |
|FISHER EXACT | P=0.294N P=0.294N P=0.541 | P=0.500N P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/120 (1%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 1.2% 0.0% 0.0% 2.2% | 2.4% 0.0% 5.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/85 (1%) 0/41 (0%) 0/41 (0%) 1/46 (2%) | 1/41 (2%) 0/41 (0%) 1/37 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 728 (T) --- --- 728 (T) | 735 (T) --- 686 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.478 P=0.645N P=0.645N P=0.618 | P=0.486N P=0.500N P=0.468 P=0.515N |
|INCIDENTAL TUMOR | P=0.478 P=0.645N P=0.645N P=0.618 | P=0.413N P=0.500N P=0.595 P=0.515N |
|LOGISTIC REGRESSION | P=0.478 P=0.645N P=0.645N P=0.618 | P=0.472N P=0.500N P=0.490 P=0.515N |
|COCHRAN-ARMITAGE | P=0.462 | P=0.461N |
|FISHER EXACT | P=0.667N P=0.667N P=0.557 | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/120 (4%) 0/60 (0%) 0/60 (0%) 1/60 (2%) | 3/60 (5%) 2/60 (3%) 4/60 (7%) 2/60 (3%) |
|ADJUSTED (b) | 5.6% 0.0% 0.0% 2.2% | 7.3% 4.7% 10.3% 5.3% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/85 (4%) 0/41 (0%) 0/41 (0%) 1/46 (2%) | 3/41 (7%) 1/41 (2%) 3/37 (8%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | 574 --- --- 728 (T) | 735 (T) 620 661 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.168N P=0.138N P=0.138N P=0.311N | P=0.522N P=0.498N P=0.450 P=0.535N |
|INCIDENTAL TUMOR | P=0.289N P=0.131N P=0.205N P=0.540N | P=0.426N P=0.439N P=0.530 P=0.535N |
|LOGISTIC REGRESSION | P=0.229N P=0.131N P=0.130N P=0.479N | P=0.501N P=0.493N P=0.479 P=0.535N |
|COCHRAN-ARMITAGE | P=0.174N | P=0.479N |
|FISHER EXACT | P=0.128N P=0.128N P=0.347N | P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/120 (5%) 0/60 (0%) 0/60 (0%) 2/60 (3%) | 4/60 (7%) 2/60 (3%) 6/60 (10%) 2/60 (3%) |
|ADJUSTED (b) | 6.7% 0.0% 0.0% 4.3% | 9.8% 4.7% 15.1% 5.3% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/85 (5%) 0/41 (0%) 0/41 (0%) 2/46 (4%) | 4/41 (10%) 1/41 (2%) 4/37 (11%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | 574 --- --- 728 (T) | 735 (T) 620 661 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.283N P=0.100N P=0.099N P=0.419N | P=0.439N P=0.337N P=0.316 P=0.372N |
|INCIDENTAL TUMOR | P=0.433N P=0.094N P=0.146N P=0.634N | P=0.323N P=0.287N P=0.444 P=0.372N |
|LOGISTIC REGRESSION | P=0.295N P=0.094N P=0.092N P=0.582N | P=0.413N P=0.330N P=0.347 P=0.372N |
|COCHRAN-ARMITAGE | P=0.299N | P=0.390N |
|FISHER EXACT | P=0.084N P=0.084N P=0.466N | P=0.340N P=0.372 P=0.340N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/120 (0%) 0/60 (0%) 2/60 (3%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 4/60 (7%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.9% 0.0% | 4.9% 0.0% 9.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/85 (0%) 0/41 (0%) 2/41 (5%) 0/46 (0%) | 2/41 (5%) 0/41 (0%) 2/37 (5%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 728 (T) --- | 735 (T) --- 420 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.478 (e) P=0.099 (e) | P=0.365N P=0.238N P=0.303 P=0.255N |
|INCIDENTAL TUMOR | P=0.478 (e) P=0.099 (e) | P=0.403N P=0.238N P=0.350 P=0.255N |
|LOGISTIC REGRESSION | P=0.478 (e) P=0.099 (e) | P=0.345N P=0.238N P=0.334 P=0.255N |
|COCHRAN-ARMITAGE | P=0.462 | P=0.338N |
|FISHER EXACT | (e) P=0.110 (e) | P=0.248N P=0.340 P=0.248N |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 7/120 (6%) 3/60 (5%) 1/60 (2%) 2/60 (3%) | 13/60 (22%) 6/60 (10%) 7/60 (12%) 6/60 (10%) |
|ADJUSTED (b) | 8.0% 7.3% 2.4% 4.3% | 30.2% 13.7% 17.4% 14.7% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/85 (6%) 3/41 (7%) 1/41 (2%) 2/46 (4%) | 11/41 (27%) 4/41 (10%) 5/37 (14%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 633 728 (T) 728 (T) 728 (T) | 708 493 618 583 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.191N P=0.564N P=0.194N P=0.323N | P=0.113N P=0.068N P=0.160N P=0.095N |
|INCIDENTAL TUMOR | P=0.238N P=0.517N P=0.184N P=0.452N | P=0.050N* P=0.057N P=0.062N P=0.033N* |
|LOGISTIC REGRESSION | P=0.200N P=0.551N P=0.182N P=0.344N | P=0.039N* P=0.058N P=0.119N P=0.073N |
|COCHRAN-ARMITAGE | P=0.213N | P=0.079N |
|FISHER EXACT | P=0.559N P=0.189N P=0.372N | P=0.066N P=0.110N P=0.066N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 50/120 (42%) 38/60 (63%) 34/60 (57%) 45/60 (75%) | 25/60 (42%) 33/60 (55%) 35/60 (58%) 34/60 (57%) |
|ADJUSTED (b) | 53.1% 86.2% 75.2% 89.9% | 56.1% 73.2% 83.2% 80.6% |
|INTERIM SACRIFICE 1 (c)| 5/20 (25%) 2/10 (20%) 2/10 (20%) 2/10 (20%) | 3/10 (30%) 1/10 (10%) 1/10 (10%) 2/10 (20%) |
|TERMINAL (d) | 42/85 (49%) 35/41 (85%) 30/41 (73%) 41/46 (89%) | 22/41 (54%) 29/41 (71%) 30/37 (81%) 30/38 (79%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 (I) 456 (I) 456 (I) | 457 (I) 457 (I) 457 (I) 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.001 ** P=0.023 * P<0.001 ** | P=0.018 * P=0.086 P=0.009 ** P=0.021 * |
|INCIDENTAL TUMOR | P<0.001 ** P=0.002 ** P=0.018 * P<0.001 ** | P=0.033 * P=0.095 P=0.021 * P=0.031 * |
|LOGISTIC REGRESSION | P<0.001 ** P=0.003 ** P=0.039 * P<0.001 ** | P=0.038 * P=0.095 P=0.026 * P=0.042 * |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.084 |
|FISHER EXACT | P=0.005 ** P=0.041 * P<0.001 ** | P=0.100 P=0.050 * P=0.072 |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 675 1350 2700 | 0 MG/KG 675 1350 2700 |
| | FEED RTD MG/KG MG/KG MG/KG | MG/KG MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 41/120 (34%) 26/60 (43%) 30/60 (50%) 15/60 (25%) | 20/60 (33%) 19/60 (32%) 26/60 (43%) 18/60 (30%) |
|ADJUSTED (b) | 43.0% 55.2% 62.2% 32.6% | 43.9% 41.3% 57.1% 42.2% |
|INTERIM SACRIFICE 1 (c)| 0/20 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 31/85 (36%) 20/41 (49%) 23/41 (56%) 15/46 (33%) | 16/41 (39%) 14/41 (34%) 18/37 (49%) 14/38 (37%) |
|FIRST INCIDENCE (DAYS) | 420 567 456 (I) 728 (T) | 429 493 171 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.146N P=0.132 P=0.028 * P=0.090N | P=0.488 P=0.493N P=0.108 P=0.520N |
|INCIDENTAL TUMOR | P=0.351N P=0.154 P=0.028 * P=0.253N | P=0.364N P=0.444N P=0.243 P=0.413N |
|LOGISTIC REGRESSION | P=0.293N P=0.173 P=0.030 * P=0.207N | P=0.499N P=0.475N P=0.157 P=0.451N |
|COCHRAN-ARMITAGE | P=0.217N | P=0.454N |
|FISHER EXACT | P=0.150 P=0.030 * P=0.139N | P=0.500N P=0.174 P=0.422N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 75/120 (63%) 47/60 (78%) 44/60 (73%) 47/60 (78%) | 37/60 (62%) 38/60 (63%) 43/60 (72%) 38/60 (63%) |
|ADJUSTED (b) | 74.0% 94.0% 87.9% 94.0% | 78.4% 79.1% 91.3% 86.1% |
|INTERIM SACRIFICE 1 (c)| 5/20 (25%) 2/10 (20%) 3/10 (30%) 2/10 (20%) | 3/10 (30%) 1/10 (10%) 1/10 (10%) 2/10 (20%) |
|TERMINAL (d) | 59/85 (69%) 38/41 (93%) 35/41 (85%) 43/46 (93%) | 31/41 (76%) 31/41 (76%) 33/37 (89%) 32/38 (84%) |
|FIRST INCIDENCE (DAYS) | 420 456 (I) 456 (I) 456 (I) | 429 457 (I) 171 457 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.098 P=0.019 * P=0.081 P=0.099 | P=0.203 P=0.508 P=0.051 P=0.302 |
|INCIDENTAL TUMOR | P=0.003 ** P=0.012 * P=0.082 P=0.005 ** | P=0.367 P=0.557 P=0.150 P=0.422 |
|LOGISTIC REGRESSION | P=0.007 ** P=0.016 * P=0.114 P=0.009 ** | P=0.345 P=0.557 P=0.118 P=0.457 |
|COCHRAN-ARMITAGE | P=0.022 * | P=0.427 |
|FISHER EXACT | P=0.023 * P=0.099 P=0.023 * | P=0.500 P=0.166 P=0.500 |
|=================================================================================================================================|
DATE: 04/03/96 EXPERIMENT: 05099 TEST: 08 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SALICYLAZOSULFAPYRIDINE
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 456
Female interim sacrifices(days): 457
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).