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TDMS Study 05099-07 Pathology Tables

NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96
Route: GAVAGE                                                                                                     Time: 19:12:10




       Facility:  Southern Research Institute

       Chemical CAS #:  599-79-1

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            2            5            4                                     
    Moribund Sacrifice                                12           13           14           11                                     
    Dosing Accident                                    1            1                         9                                     
  Survivors                                                                                                                         
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                34           33           31           26                                     
    Moribund Sacrifice                                 1                                                                            

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (60)         (60)         (60)         (59)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
      Leiomyoma                                                     1 (2%)                                                          
   Liver                                              (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
   Mesentery                                          (4)          (8)          (5)          (6)                                    
      Carcinoma, Metastatic, Uterus                                 1 (13%)                                                         
      Fibroma                                                       1 (13%)                                                         
   Pancreas                                           (60)         (60)         (60)         (60)                                   
   Pharynx                                            (1)                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
   Tongue                                             (1)          (1)          (1)                                                 
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma Malignant                             3 (5%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Ganglioneuroma                                   1 (2%)                                                                       
      Pheochromocytoma Benign                                                    3 (5%)                                             
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (60)         (59)         (60)         (60)                                   
      Pars Distalis, Adenoma                          27 (45%)     20 (34%)     24 (40%)     13 (22%)                               
      Pars Distalis, Carcinoma                                      2 (3%)                                                          
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Adenoma                                  3 (5%)       5 (8%)       2 (3%)       5 (8%)                                
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                                                   2 (3%)                                             
      Follicular Cell, Carcinoma                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                          2 (3%)       3 (5%)       2 (3%)       2 (3%)                                
      Carcinoma                                        1 (2%)       2 (3%)       1 (2%)                                             
   Ovary                                              (60)         (60)         (60)         (60)                                   
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                                     1 (2%)                                                          
      Polyp Stromal                                    6 (10%)      8 (13%)      8 (13%)      4 (7%)                                
      Polyp Stromal, Multiple                                                                 1 (2%)                                
      Sarcoma Stromal                                                                         1 (2%)                                
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
   Lymph Node                                         (12)         (9)          (9)          (7)                                    
   Lymph Node, Mandibular                             (60)         (58)         (60)         (60)                                   
   Lymph Node, Mesenteric                             (60)         (60)         (59)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
   Thymus                                             (59)         (59)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (58)                                   
      Adenoma                                                       1 (2%)       2 (3%)                                             
      Carcinoma                                        2 (3%)                    3 (5%)       1 (2%)                                
      Fibroadenoma                                    18 (30%)      8 (13%)     18 (30%)      5 (9%)                                
      Fibroadenoma, Multiple                           4 (7%)       1 (2%)       2 (3%)                                             
   Skin                                               (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Keratoacanthoma                                  1 (2%)                    1 (2%)       1 (2%)                                
      Sarcoma                                                                                 1 (2%)                                
      Squamous Cell Papilloma                          3 (5%)                                                                       
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)                       (1)                                    
      Carcinoma, Metastatic, Uterus                                 1 (100%)                                                        
      Rhabdomyosarcoma                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland                        3 (5%)                                                          
      Glioma Malignant, Mixed                                       1 (2%)                                                          
      Meningioma Malignant                                          1 (2%)                                                          
   Spinal Cord                                                                               (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Nose                                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Carcinoma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
      Transitional Epithelium, Papilloma                                                      2 (3%)                                
   Urinary Bladder                                    (59)         (60)         (60)         (60)                                   
      Papilloma                                                                  2 (3%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leukemia Mononuclear                            15 (25%)      9 (15%)      9 (15%)      3 (5%)                                
      Lymphoma Malignant                                            1 (2%)                    1 (2%)                                
      Lymphoma Malignant Mixed                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      84 MG/KG     168          337.5                                     
                                                                             MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          43          49          33                                       
     Total Primary Neoplasms                           91          72          88          50                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          32          45          27                                       
     Total Benign Neoplasms                            69          50          70          37                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          20          17          12                                       
     Total Malignant Neoplasms                         22          21          18          13                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          5                       2                                       
     Total Metastatic Neoplasm                                      8                       3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           60           60           60           60           70           

  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           16           11           16           15           13           
    Natural Death                                      1            1            2            2           10            4           
    Dosing Accident                                    1            2            4            1            2            3           
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           31           33           30           23           30           
    Natural Death                                                                             1                                     

  Animals Examined Microscopically                    70           60           60           60           60           70           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (69)         (60)         (59)         (60)         (58)         (68)         
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (1%)                                                                       
   Intestine Large, Rectum                            (69)         (60)         (60)         (60)         (59)         (69)         
      Polyp                                                         1 (2%)                                                          
   Intestine Large, Cecum                             (70)         (60)         (60)         (60)         (60)         (70)         
      Sarcoma                                                       1 (2%)                                                          
   Intestine Small, Duodenum                          (70)         (60)         (60)         (60)         (60)         (69)         
      Carcinoma                                                                                                         1 (1%)      
   Intestine Small, Jejunum                           (70)         (60)         (59)         (60)         (59)         (69)         
   Intestine Small, Ileum                             (69)         (60)         (59)         (60)         (60)         (69)         
      Leiomyosarcoma                                   1 (1%)                                                                       
   Liver                                              (70)         (60)         (60)         (60)         (60)         (70)         
      Fibrous Histiocytoma, Metastatic, Skin                                                               1 (2%)                   
      Hepatocellular Carcinoma                                                   1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           2 (3%)       2 (3%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (1%)                                                                       
      Osteosarcoma, Metastatic, Bone                                                                       1 (2%)                   
      Osteosarcoma, Metastatic, Tissue NOS                                                    1 (2%)                                
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (2%)                                                          
   Mesentery                                          (19)         (19)         (17)         (19)         (14)         (18)         
      Fibrous Histiocytoma                             1 (5%)                                                                       
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (5%)                                                                       
      Osteosarcoma, Metastatic, Tissue NOS                                                    1 (5%)                                
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (5%)                                                          
   Pancreas                                           (70)         (60)         (60)         (60)         (60)         (68)         

                                                             Page   7                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Fibrous Histiocytoma                             1 (1%)                                                                       
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (1%)                                                                       
      Mixed Tumor Benign                                                         1 (2%)                    1 (2%)                   
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (2%)                                                          
      Acinar Cell, Adenoma                             9 (13%)     10 (17%)      6 (10%)      5 (8%)      10 (17%)      2 (3%)      
      Acinar Cell, Adenoma, Multiple                   3 (4%)       2 (3%)                    2 (3%)                    2 (3%)      
      Acinar Cell, Carcinoma, Multiple                 1 (1%)                                                                       
   Pharynx                                                                                   (2)                       (1)          
      Squamous Cell Carcinoma                                                                 1 (50%)                               
      Squamous Cell Papilloma                                                                 1 (50%)                   1 (100%)    
   Salivary Glands                                    (70)         (60)         (59)         (60)         (60)         (70)         
      Adenoma                                                                                              1 (2%)                   
      Schwannoma Malignant                                          1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Skin                                                                            1 (1%)      
   Stomach, Forestomach                               (70)         (60)         (60)         (60)         (60)         (70)         
      Leiomyosarcoma                                   1 (1%)                                                                       
      Squamous Cell Carcinoma                                                                              1 (2%)                   
      Squamous Cell Papilloma                          1 (1%)                                                                       
   Stomach, Glandular                                 (69)         (60)         (60)         (60)         (60)         (70)         
   Tongue                                             (1)                                                 (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (70)         (60)         (60)         (60)         (60)         (70)         
      Vena Cava, Chordoma, Metastatic, Spinal Cord                                            1 (2%)                                
   Heart                                              (70)         (60)         (60)         (60)         (60)         (70)         
      Schwannoma Benign                                             1 (2%)                                 2 (3%)       1 (1%)      
      Schwannoma Malignant                                                       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (70)         (60)         (60)         (60)         (60)         (70)         
      Adenoma                                                                                 1 (2%)                    2 (3%)      
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Adrenal Medulla                                    (70)         (60)         (59)         (60)         (59)         (70)         
      Pheochromocytoma Malignant                                    1 (2%)                    1 (2%)                    2 (3%)      
      Pheochromocytoma Complex                         1 (1%)                                                                       
      Pheochromocytoma Benign                         12 (17%)      7 (12%)      6 (10%)      5 (8%)       7 (12%)      4 (6%)      
      Bilateral, Pheochromocytoma Benign               3 (4%)       2 (3%)       1 (2%)       1 (2%)       1 (2%)       1 (1%)      
   Islets, Pancreatic                                 (70)         (60)         (60)         (60)         (60)         (69)         
      Adenoma                                          2 (3%)       2 (3%)       3 (5%)       6 (10%)      5 (8%)       1 (1%)      
      Carcinoma                                        1 (1%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (70)         (58)         (60)         (59)         (59)         (68)         

                                                             Page   8                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Ganglioneuroma                                   1 (1%)                                                                       
      Pars Distalis, Adenoma                          15 (21%)     23 (40%)     19 (32%)     18 (31%)     18 (31%)     20 (29%)     
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (70)         (60)         (60)         (60)         (60)         (70)         
      Bilateral, C-Cell, Carcinoma                                               1 (2%)                                             
      C-Cell, Adenoma                                  3 (4%)       6 (10%)      9 (15%)      5 (8%)       6 (10%)      4 (6%)      
      C-Cell, Carcinoma                                2 (3%)                    1 (2%)       2 (3%)       1 (2%)       2 (3%)      
      Follicular Cell, Adenoma                         4 (6%)                                 3 (5%)       1 (2%)                   
      Follicular Cell, Carcinoma                       1 (1%)                                 1 (2%)                    2 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                       (1)                                    
      Osteosarcoma                                                                            1 (100%)                              
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (60)         (60)         (60)         (60)         (70)         
   Preputial Gland                                    (70)         (60)         (60)         (60)         (60)         (70)         
      Adenoma                                          1 (1%)                    1 (2%)       3 (5%)                    5 (7%)      
      Carcinoma                                        2 (3%)                    1 (2%)       3 (5%)                    2 (3%)      
   Prostate                                           (70)         (60)         (60)         (60)         (60)         (70)         
      Adenoma                                                                    1 (2%)                                             
   Seminal Vesicle                                    (70)         (60)         (60)         (60)         (59)         (70)         
   Testes                                             (70)         (60)         (59)         (60)         (60)         (70)         
      Bilateral, Interstitial Cell, Adenoma           50 (71%)     40 (67%)     43 (73%)     45 (75%)     52 (87%)     37 (53%)     
      Interstitial Cell, Adenoma                       4 (6%)      13 (22%)      5 (8%)      11 (18%)      3 (5%)       9 (13%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (60)         (60)         (60)         (60)         (70)         
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (9)          (16)         (15)         (14)         (10)         (7)          
      Inguinal, Fibrous Histiocytoma, Metastatic,                                                                                   
           Skin                                                                                            1 (10%)                  
      Mediastinal, Osteosarcoma, Metastatic,                                                                                        
          Tissue NOS                                                                          1 (7%)                                
      Mediastinal, Sarcoma, Metastatic, Intestine                                                                                   
          Large, Cecum                                              1 (6%)                                                          
      Pancreatic, Histiocytic Sarcoma                                            1 (7%)                                             
   Lymph Node, Mandibular                             (70)         (59)         (60)         (60)         (59)         (70)         
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (70)         (60)         (60)         (60)         (59)         (69)         

                                                             Page   9                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (2%)                                                          
   Spleen                                             (70)         (60)         (60)         (60)         (60)         (70)         
      Fibrosarcoma                                                  1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (1%)                                                                       
      Osteosarcoma, Metastatic, Tissue NOS                                                    1 (2%)                                
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (2%)                                                          
   Thymus                                             (66)         (60)         (58)         (59)         (59)         (69)         
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (67)         (58)         (58)         (57)         (59)         (68)         
      Carcinoma                                                                               1 (2%)                                
      Fibroadenoma                                     3 (4%)       1 (2%)       4 (7%)       4 (7%)       3 (5%)       4 (6%)      
      Fibroadenoma, Multiple                                                                  1 (2%)                                
   Skin                                               (70)         (59)         (60)         (60)         (59)         (70)         
      Basal Cell Adenoma                               2 (3%)                    3 (5%)                                             
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Keratoacanthoma                                  3 (4%)       2 (3%)       3 (5%)       3 (5%)       2 (3%)       3 (4%)      
      Squamous Cell Papilloma                          1 (1%)       2 (3%)       2 (3%)       3 (5%)       1 (2%)       1 (1%)      
      Trichoepithelioma                                             1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibroma                     2 (3%)       3 (5%)       5 (8%)       1 (2%)       3 (5%)       6 (9%)      
      Subcutaneous Tissue, Fibrosarcoma                                                                    1 (2%)                   
      Subcutaneous Tissue, Fibrous Histiocytoma                                                            1 (2%)                   
      Subcutaneous Tissue, Lipoma                                                                                       1 (1%)      
      Subcutaneous Tissue, Liposarcoma                                           1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Benign                                                                            1 (1%)      
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                    1 (2%)                    2 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (60)         (60)         (60)         (60)         (70)         
      Hamartoma                                                                  1 (2%)                                             
      Osteosarcoma                                                                                         1 (2%)       1 (1%)      
   Skeletal Muscle                                    (1)          (1)          (1)          (1)          (1)          (1)          
      Fibrous Histiocytoma                             1 (100%)                                                                     
      Hemangiosarcoma                                                                                                   1 (100%)    
      Histiocytic Sarcoma                                                        1 (100%)                                           
      Osteosarcoma, Metastatic, Tissue NOS                                                    1 (100%)                              
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (60)         (60)         (60)         (60)         (70)         
      Astrocytoma Malignant                            1 (1%)                                                                       
      Glioma Malignant                                                                        1 (2%)                                
      Granular Cell Tumor Benign                                    1 (2%)                                                          
      Meningioma Benign                                                                                                 1 (1%)      
   Spinal Cord                                                     (1)          (1)          (1)                       (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (60)         (60)         (60)         (60)         (70)         
      Alveolar/Bronchiolar Adenoma                     2 (3%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (1%)                                                           2 (3%)      
      Chordoma, Metastatic, Spinal Cord                                                       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                                                       1 (2%)       1 (1%)      
      Osteosarcoma, Metastatic, Tissue NOS                                                    1 (2%)                                
      Sarcoma, Metastatic, Intestine Large, Cecum                   1 (2%)                                                          
   Nose                                               (70)         (60)         (60)         (60)         (60)         (70)         
      Squamous Cell Carcinoma                          1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (2)                                                              
      Carcinoma                                        1 (100%)     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (60)         (60)         (60)         (60)         (70)         
      Lipoma                                                                                  1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                                                    1 (1%)      
      Renal Tubule, Adenoma                                         1 (2%)                    1 (2%)                                
   Urinary Bladder                                    (70)         (60)         (59)         (60)         (60)         (67)         
      Papilloma                                                                               2 (3%)       4 (7%)                   
      Papilloma, Multiple                                                                                  2 (3%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(70)        *(60)        *(60)        *(60)        *(60)        *(70)         
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            13 (19%)     10 (17%)     18 (30%)     12 (20%)      3 (5%)      10 (14%)     
      Mesothelioma Malignant                           1 (1%)       1 (2%)       1 (2%)       2 (3%)       3 (5%)       2 (3%)      
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(70)        *(60)        *(60)        *(60)        *(60)        *(70)         
____________________________________________________________________________________________________________________________________

                                                             Page  12                                                               
NTP Experiment-Test: 05099-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 19:12:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG      84 MG/KG     168          337.5        337.5           
                                                                FEED RTD                  MG/KG        MG/KG        STOP            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            58          59          56          59          58          56               
     Total Primary Neoplasms                          156         141         143         152         134         133               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 58          59          54          58          57          52               
     Total Benign Neoplasms                           124         122         114         124         122         106               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          16          24          23           9          21               
     Total Malignant Neoplasms                         32          19          29          28          12          27               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                       4           5           4               
     Total Metastatic Neoplasm                          5           9                      12          13           7               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  13                                                               
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