TDMS Study 05099-07 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL SALICYLAZOSULFAPYRIDINE NTP Experiment-Test: 05099-07 Report: PEIRPT09 Study Type: CHRONIC Date: 04/07/95 Route: GAVAGE Time: 00:41:54 CORE STUDY Facility: Southern Research Institute Chemical CAS #: 599-79-1 Lock Date: 02/03/93 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 MG/KG Include 002 0 MG/KG Include 003 84 MG/KG Include 004 84 MG/KG Include 005 168 MG/KG Include 006 168 MG/KG Include 007 337.5 MG/KG Include 008 337.5 MG/KG Page 1 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3| | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Perforation | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Subacute | | Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Eosinophilic Focus | X X X X X X| Granuloma | 1 1 1 1 3 1| Hematopoietic Cell Proliferation | 2 | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X X X X X | Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 | Centrilobular, Atrophy | 2 2 | Hepatocyte, Vacuolization Cytoplasmic| 4 1 2 | Kupffer Cell, Pigmentation | 3 | Lobules, Necrosis | | __________________________________________________________________________| Mesentery | + + | Accessory Spleen | | Fat, Necrosis | 2 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 1 1 1 1 3 2 | Metaplasia, Hepatocyte | X | Acinar Cell, Cytoplasmic Alteration | 3 | Acinar Cell, Hyperplasia, Focal | 2| __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Inflammation, Chronic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Ulcer | | Mucosa, Hyperplasia | 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3| | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Erosion | 2 | Ulcer | | __________________________________________________________________________| Tongue | + | Mucosa, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 1 1 | Inflammation, Subacute | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X X X X | Cyst | | Degeneration, Fatty | 1 | Hematopoietic Cell Proliferation | 2 | Hemorrhage | 2 | Hyperplasia, Focal | 1 1 2 | Hypertrophy, Focal | 1 1 | Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | Necrosis | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 2 2 2 3 4 2 4 | Pars Distalis, Cyst | X X X X X X X X X X X X X X X X X| Pars Distalis, Hyperplasia, Focal | 2 4 1 1 3 2 | Pars Intermedia, Angiectasis | | Pars Intermedia, Cyst | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 2 1 2 1 | Follicle, Cyst | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 4 2 3 3 2 2| Hyperplasia | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3| | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | 2 | Inflammation, Suppurative | 2 1| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Hydrometra | | Hyperplasia, Cystic | 2 | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | 3 | Necrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + | Mediastinal, Hemorrhage | 2 3 2 | Mediastinal, Pigmentation | 3 3 3 3 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 | Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 3 | Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 3 | Pigmentation | 2 2 3 2 2| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | Hemorrhage | 4 | Necrosis | 2 | Pigmentation, Hemosiderin | 2 3 2 2 2 2 1 2 3 3 3 2 3 2 3 3 3 2 3| Lymphoid Follicle, Atrophy | | Lymphoid Follicle, Hyperplasia | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 2 1 | Hyperplasia, Lobular | 3 2 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 | Cyst Epithelial Inclusion | | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3| | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Osteopetrosis | 2 | Femur, Osteopetrosis | 2 | __________________________________________________________________________| Skeletal Muscle | | Hemorrhage | | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X | Hemorrhage | | Hydrocephalus | 2 | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Edema | | Foreign Body | | Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 | Inflammation, Subacute | | Alveolar Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X X | Foreign Body | | Fungus | | Mucosa, Hyperplasia | 1 | Mucosa, Metaplasia, Squamous | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 3 | Inflammation, Chronic | | Inflammation, Suppurative | | Retina, Atrophy | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | Mineralization | 2 3 2 1 1 1 2 2 1 1 2 2 1 2 2 2 2 1 2 1 2| Nephropathy | 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3| | 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Dilatation | 2 | Renal Tubule, Necrosis | | Renal Tubule, Pigmentation | 2 3 2 3 | Transitional Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +| Mucosa, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| | | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Perforation | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 2 | 1 2.0| Inflammation, Subacute | 2 | 1 2.0| Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 2 3.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 45 | Clear Cell Focus | X X X X X | 9 | Eosinophilic Focus | X X X X X X X | 13 | Granuloma | 1 1 1 1 1 1 3 3 1 | 15 1.4| Hematopoietic Cell Proliferation | 2 | 2 2.0| Hepatodiaphragmatic Nodule | X X X X| 6 | Mixed Cell Focus | X X X | 10 | Bile Duct, Hyperplasia | 1 1 3 1 1 1 1 1 | 16 1.2| Centrilobular, Atrophy | 2 2 | 4 2.0| Hepatocyte, Vacuolization Cytoplasmic| 2 | 4 2.3| Kupffer Cell, Pigmentation | 1 4 | 3 2.7| Lobules, Necrosis | 1 1 | 2 1.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Accessory Spleen | X | 1 | Fat, Necrosis | 3 | 3 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 1 2 2 | 17 1.3| Metaplasia, Hepatocyte | | 1 | Acinar Cell, Cytoplasmic Alteration | 3 | 2 3.0| Acinar Cell, Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 | 1 2.0| Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| | | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Ulcer | 4 | 1 4.0| Mucosa, Hyperplasia | | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 | 2 1.5| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Tongue | | 1 | Mucosa, Hyperplasia | | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 1 1 2 1 | 12 1.3| Inflammation, Subacute | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X X| 13 | Cyst | X | 1 | Degeneration, Fatty | 1 1 2 4 | 5 1.8| Hematopoietic Cell Proliferation | | 1 2.0| Hemorrhage | | 1 2.0| Hyperplasia, Focal | 2 1 2 | 6 1.5| Hypertrophy, Focal | 1 3 2 2 | 6 1.7| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 3.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 1 3 2 3 | 12 2.6| Pars Distalis, Cyst | X X X X X X X X X X X X| 29 | Pars Distalis, Hyperplasia, Focal | 3 3 2 2 3 | 11 2.4| Pars Intermedia, Angiectasis | 3 3 | 2 3.0| Pars Intermedia, Cyst | X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| | | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Hyperplasia | 3 2 1 | 7 1.7| Follicle, Cyst | X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 3 3 3 2 3 3 3 3| 17 2.8| Hyperplasia | 2 | 1 2.0| Inflammation, Chronic | 2 2 3| 4 2.3| Inflammation, Suppurative | 4 3| 4 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X X X X | 7 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Hydrometra | 2 2 2| 3 2.0| Hyperplasia, Cystic | 2 2 | 3 2.0| __________________________________________________________________________|____________| Vagina | M | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myelofibrosis | 2 3 | 3 2.7| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + | 12 | Mediastinal, Hemorrhage | 2 2 3 | 6 2.3| Mediastinal, Pigmentation | 3 4 | 7 3.1| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 3 2 2 2| 7 2.1| Hemorrhage | 1 1 | 3 1.3| Hyperplasia, Lymphoid | 3 2 | 4 2.5| Pigmentation | 2 2 2 2 2 | 6 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 2 2.0| Pigmentation | 2 3 2 3 3 | 10 2.4| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 2 | 3 2.3| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 | 25 2.0| Hemorrhage | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| | | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Necrosis | | 1 2.0| Pigmentation, Hemosiderin | 3 2 1 3 3 3 2 3 2 2 2 3 2 2 2 2 2 2 2| 38 2.3| Lymphoid Follicle, Atrophy | 2 | 1 2.0| Lymphoid Follicle, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 1 2 1 1 1 1 2 | 10 1.3| Hyperplasia, Lobular | | 4 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | | 1 1.0| Cyst Epithelial Inclusion | X | 1 | Inflammation, Chronic | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calvarium, Osteopetrosis | 2 2 2 | 4 2.0| Femur, Osteopetrosis | 2 4 2 4 | 5 2.8| __________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | Hemorrhage | 3 | 1 3.0| Inflammation, Chronic | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X X X X | 10 | Hemorrhage | 3 3 | 2 3.0| Hydrocephalus | 2 2 | 3 2.0| Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Edema | 2 | 1 2.0| Foreign Body | 1 | 1 1.0| Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1| 14 1.1| Inflammation, Subacute | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 1 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| | | 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X X X X X X | 9 | Foreign Body | 2 2 2 | 3 2.0| Fungus | X | 1 | Mucosa, Hyperplasia | 2 1 2 | 4 1.5| Mucosa, Metaplasia, Squamous | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | Cataract | | 1 3.0| Inflammation, Chronic | 3 | 1 3.0| Inflammation, Suppurative | 4 | 1 4.0| Retina, Atrophy | 1 | 2 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 2.0| Mineralization | 2 1 1 1 2 2 2 3 3 1 2 1 2 2 1 3 2 2 1 2 1 2 1 | 44 1.7| Nephropathy | 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 | 34 1.1| Renal Tubule, Dilatation | 2 | 2 2.0| Renal Tubule, Necrosis | 2 | 1 2.0| Renal Tubule, Pigmentation | 2 2 2 2 | 8 2.3| Transitional Epithelium, Hyperplasia | 1 1 | 3 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mucosa, Hyperplasia | 1 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4| | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 3 3 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Eosinophilic Focus | X X X X X X X X X | Granuloma | 1 2 1 1 1 | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X X X | Mixed Cell Focus | X X| Bile Duct, Hyperplasia | 1 1 1 1 1 | Centrilobular, Atrophy | 2 3 | Hepatocyte, Vacuolization Cytoplasmic| | Lobules, Necrosis | 1 2 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 1 3 1 1 1 1 1| Metaplasia, Hepatocyte | | Acinar Cell, Cytoplasmic Alteration | 3 | Acinar Cell, Hyperplasia, Focal | 2 4 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +| Erosion | 1 | Mucosa, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4| | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X X| Angiectasis | 2 3 3 | Degeneration, Fatty | 1 1 2 4 1| Hemorrhage | 3 | Hyperplasia, Diffuse | 3 | Hyperplasia, Focal | 1 1 1 1 | Hypertrophy, Focal | 2 3 | Necrosis | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Pars Distalis, Angiectasis | 2 3 2 1| Pars Distalis, Cyst | X X X X X X X X X X X X X| Pars Distalis, Hyperplasia, Focal | 3 1 1 3 3 3 1 3 2 | Pars Intermedia, Angiectasis | 2 | Pars Intermedia, Cyst | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 2 1 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 3 2 3 3 4 3 2 | Hyperplasia | 1 4 | Inflammation, Chronic | 2 2 2 2 2 2 2 2 2| Inflammation, Suppurative | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 3 2 | Hyperplasia, Cystic | 2 2 | Endometrium, Hyperplasia, Focal | 4 | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypercellularity | 2 | Myelofibrosis | 4 | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4| | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + | Mediastinal, Hemorrhage | 3 3 2 | Mediastinal, Pigmentation | 3 3 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| Ectasia | 2 2 2 | Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 3 | Hyperplasia, Plasma Cell | 3 | Pigmentation | 2 2 2 2 3 2 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 1 1 4 | Hyperplasia, Lymphoid | | Pigmentation | 3 3 2 2| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 2 2 2 | Pigmentation, Hemosiderin | 3 3 2 3 2 3 3 3 3 2 2 2 3 2 2 2| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| Cyst | | Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 1 1 4 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Osteopetrosis | 2 | Femur, Osteopetrosis | 2 3 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 | Compression | X X X X | Hemorrhage | | Hydrocephalus | 2 | Mineralization | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4| | 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Edema | | Foreign Body | | Hemorrhage | | Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 3 | Inflammation, Subacute | 1 1 | Thrombosis | | Alveolar Epithelium, Hyperplasia | 1 2 2 3| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X X X X X| Foreign Body | 2 2 2 1 | Fungus | X X | Mucosa, Hyperplasia | 2 2 | Mucosa, Metaplasia, Squamous | 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 3 | Phthisis Bulbi | | Retina, Atrophy | 4 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Concretion | 3 1 1 1 2| Cyst | | Mineralization | 2 2 3 3 2 1 2 1 2 2 2 1 1 1 3 1 1 1 2 1 2 1 2| Nephropathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 3 1 2 1 1 2 | Renal Tubule, Dilatation | 2 | Renal Tubule, Hyperplasia | 4 | Renal Tubule, Pigmentation | 2 2 | Transitional Epithelium, Hyperplasia | 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| | | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X| 6 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 3 2.3| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 | Clear Cell Focus | X X X | 7 | Eosinophilic Focus | X X X X | 13 | Granuloma | 1 1 1 | 8 1.1| Hematopoietic Cell Proliferation | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X X X X | 9 | Mixed Cell Focus | X X X X X | 7 | Bile Duct, Hyperplasia | 2 1 2 1 1 1 | 11 1.2| Centrilobular, Atrophy | | 2 2.5| Hepatocyte, Vacuolization Cytoplasmic| 4 | 1 4.0| Lobules, Necrosis | | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + | 7 | Fat, Necrosis | 2 2 | 4 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 2 2 1 1 | 16 1.4| Metaplasia, Hepatocyte | X | 1 | Acinar Cell, Cytoplasmic Alteration | 3 | 2 3.0| Acinar Cell, Hyperplasia, Focal | | 3 2.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Erosion | | 1 1.0| Mucosa, Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| | | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 1 | 11 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X | 8 | Angiectasis | 3 4 | 5 3.0| Degeneration, Fatty | 1 4 2 1 2 | 10 1.9| Hemorrhage | | 1 3.0| Hyperplasia, Diffuse | | 1 3.0| Hyperplasia, Focal | 1 1 | 6 1.0| Hypertrophy, Focal | 2 2| 4 2.3| Necrosis | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 2 | 5 2.0| Pars Distalis, Cyst | X X X X X X X X X X X X X | 26 | Pars Distalis, Hyperplasia, Focal | 4 3 1 1 | 13 2.2| Pars Intermedia, Angiectasis | 3 2| 3 2.3| Pars Intermedia, Cyst | X X X | 5 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | | 1 | C-Cell, Hyperplasia | 1 1 1 1 | 10 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 4 3 2 3 3 4 | 15 2.9| Hyperplasia | | 2 2.5| Inflammation, Chronic | 2 2 2 3 2 2 | 15 2.1| Inflammation, Suppurative | 2 2 | 2 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X X| 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| | | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 2 | 3 2.3| Hyperplasia, Cystic | | 2 2.0| Endometrium, Hyperplasia, Focal | | 1 4.0| __________________________________________________________________________|____________| Vagina | M + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypercellularity | 4 2 | 3 2.7| Myelofibrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + | 6 | Mediastinal, Hemorrhage | 3 | 4 2.8| Mediastinal, Pigmentation | 4 | 4 3.3| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Ectasia | 2 2 2 2 | 7 2.0| Hemorrhage | 1 2 | 3 1.7| Hyperplasia, Lymphoid | 2 3 2 | 5 2.4| Hyperplasia, Plasma Cell | | 1 3.0| Pigmentation | 2 3 2 3 2 2| 14 2.2| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 1 | 1 1.0| Hemorrhage | 1 | 4 1.8| Hyperplasia, Lymphoid | 2 | 1 2.0| Pigmentation | 3 3 3 3 2| 9 2.7| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 3 3 2 2| 27 2.1| Pigmentation, Hemosiderin | 2 3 1 2 2 2 3 4 2 3 2 3 2 2 2 2 2| 33 2.4| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X| 1 | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 3 2 2 1 | 10 2.1| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| | | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Calvarium, Osteopetrosis | | 1 2.0| Femur, Osteopetrosis | 3 | 3 2.7| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Compression | X X X X X X X | 11 | Hemorrhage | 3 2 | 2 2.5| Hydrocephalus | 2 2 | 3 2.0| Mineralization | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 3 3 | 3 2.7| Edema | 2 | 1 2.0| Foreign Body | 1 2 | 2 1.5| Hemorrhage | 1 1 | 2 1.0| Infiltration Cellular, Histiocyte | 2 1 3 | 13 1.5| Inflammation, Subacute | 1 1 2 | 5 1.2| Thrombosis | X | 1 | Alveolar Epithelium, Hyperplasia | 2 1 2 | 7 1.9| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X X X | 9 | Foreign Body | 2 1 | 6 1.7| Fungus | | 2 | Mucosa, Hyperplasia | | 2 2.0| Mucosa, Metaplasia, Squamous | | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + | 5 | Cataract | 2 4 | 3 3.0| Phthisis Bulbi | X X | 2 | Retina, Atrophy | 4 | 2 4.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| | DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| | | 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Concretion | 1 2 2 1 | 9 1.6| Cyst | X | 1 | Mineralization | 2 3 2 1 2 2 1 1 1 2 2 2 2 1 2 1 2 3 3 1 2 2 1 1| 47 1.7| Nephropathy | 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1| 36 1.2| Renal Tubule, Dilatation | 2| 2 2.0| Renal Tubule, Hyperplasia | | 1 4.0| Renal Tubule, Pigmentation | 3 2 2 2 | 6 2.2| Transitional Epithelium, Hyperplasia | 1 1 2 1 1 | 7 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3| | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 1| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X | Developmental Malformation | X | Eosinophilic Focus | X X X X X X | Granuloma | 1 1 2 | Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X X X X X X | Bile Duct, Hyperplasia | 2 1 3 1 1 1 1| Lobules, Necrosis | 1 | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 2 1 2 | Metaplasia, Hepatocyte | X | Acinar Cell, Cytoplasmic Alteration | 3 3 | Acinar Cell, Hyperplasia, Focal | 4 2| __________________________________________________________________________| Pharynx | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Mucosa, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | Mucosa, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 2 | Mineralization | 3 | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3| | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X X X | Angiectasis | 3 | Cyst | X | Degeneration, Fatty | 2 | Hyperplasia, Focal | 1 1 | Hypertrophy, Focal | 1 1 2 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 3 4 | Pars Distalis, Cyst | X X X X X X X X X| Pars Distalis, Hyperplasia, Focal | 3 2 3 3| Pars Intermedia, Angiectasis | | Pars Intermedia, Cyst | X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X X | C-Cell, Hyperplasia | 2 2 1 2 4 2 | Follicle, Cyst | X X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 3 2 2 3 2 2| Hyperplasia | | Inflammation, Chronic | 2 3 3 | Inflammation, Suppurative | 2 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 3 2| Hyperplasia, Cystic | 1 | __________________________________________________________________________| Vagina | | Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypercellularity | 2 | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3| | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + | Mediastinal, Ectasia | | Mediastinal, Hemorrhage | 1 | Mediastinal, Pigmentation | 3 2 3 3 | Pancreatic, Hemorrhage | 2 | Pancreatic, Pigmentation | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 1 1 | Hyperplasia, Lymphoid | 3 | Pigmentation | 2 3 3 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Pigmentation | 3 3 3 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | X | Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Hemorrhage | 3 | Pigmentation, Hemosiderin | 2 2 3 3 3 3 2 3 2 2 3 4 2 3 2 3 2 3 2| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 2 1 1 2 2 1 1 1 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 1 2 | Hyperkeratosis | | Inflammation, Chronic | 2 | Ulcer | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Calvarium, Osteopetrosis | | Femur, Osteopetrosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X X | Hydrocephalus | 2 2 | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3| | 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 2 | Edema | 2 2 | Foreign Body | 2 | Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 | Inflammation, Subacute | | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X X X X X | Foreign Body | 1 2 2 2 | Mucosa, Hyperplasia | 2 | Mucosa, Metaplasia, Squamous | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | | Phthisis Bulbi | X | Retina, Atrophy | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Concretion | 2 1 1 2 2 1 3 2 1 1 2 1 3 2 2 2 1 2| Hydronephrosis | | Infarct | | Inflammation, Suppurative | 2 | Mineralization | 2 1 3 1 2 2 1 2 2 2 2 2 2 2 1 2 1 2 2 2| Nephropathy | 1 1 1 1 3 1 2 1 1 1 2 1 3 1 1 1 1 1 1 1| Renal Tubule, Dilatation | | Renal Tubule, Hyperplasia | 2 | Renal Tubule, Pigmentation | 2 4 | Transitional Epithelium, Hyperplasia | 1 1 1 1 2 1 1 2 1 1 1 | __________________________________________________________________________| Ureter | | Concretion | | Mucosa, Hyperplasia | | __________________________________________________________________________| Urethra | | Mucosa, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Concretion | | Mucosa, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X| 7 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X| 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 3 4 4 | 7 2.3| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 47 | Clear Cell Focus | X X X X X X | 11 | Developmental Malformation | | 1 | Eosinophilic Focus | X X X X X X X X X X X X X | 19 | Granuloma | 1 1 | 5 1.2| Hepatodiaphragmatic Nodule | X X X | 4 | Mixed Cell Focus | X X X X X | 11 | Bile Duct, Hyperplasia | 1 1 | 9 1.3| Lobules, Necrosis | 1 1 | 3 1.0| __________________________________________________________________________|____________| Mesentery | + + +| 4 | Fat, Necrosis | 3 3 2| 4 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 3 1 1 2 2 1 1 1 | 14 1.5| Metaplasia, Hepatocyte | | 1 | Acinar Cell, Cytoplasmic Alteration | 3 3 | 4 3.0| Acinar Cell, Hyperplasia, Focal | 1 2 | 4 2.3| __________________________________________________________________________|____________| Pharynx | + | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 2.0| Mucosa, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tongue | + | 1 | Mucosa, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 1 1 2 2 1 3 1 1| 16 1.4| Mineralization | 2 | 2 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X | 10 | Angiectasis | | 1 3.0| Cyst | | 1 | Degeneration, Fatty | 1 1 1 1 1| 6 1.2| Hyperplasia, Focal | 1 1 1 1 1 1 1 | 9 1.0| Hypertrophy, Focal | 1 | 5 1.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 2 3 2 | 7 2.6| Pars Distalis, Cyst | X X X X X X X X X | 18 | Pars Distalis, Hyperplasia, Focal | 3 2 1 2 3 2 2 2 | 12 2.3| Pars Intermedia, Angiectasis | 2 | 1 2.0| Pars Intermedia, Cyst | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | X | 3 | C-Cell, Hyperplasia | 1 1 2 1 | 10 1.8| Follicle, Cyst | X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 2 3 2 4 2 3 3 | 17 2.5| Hyperplasia | 2 | 1 2.0| Inflammation, Chronic | 2 2 2 2 2 | 8 2.3| Inflammation, Suppurative | 2 2 | 4 2.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Cyst | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 3 3 1| 5 2.4| Hyperplasia, Cystic | 2 | 2 1.5| __________________________________________________________________________|____________| Vagina | M + | 1 | Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypercellularity | 4 | 2 3.0| Myelofibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + +| 9 | Mediastinal, Ectasia | 2 | 1 2.0| Mediastinal, Hemorrhage | 1 3| 3 1.7| Mediastinal, Pigmentation | 3 3 4| 7 3.0| Pancreatic, Hemorrhage | | 1 2.0| Pancreatic, Pigmentation | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 2 | 3 2.0| Hemorrhage | | 2 1.0| Hyperplasia, Lymphoid | 3 2 3 | 4 2.8| Pigmentation | 2 | 6 2.7| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 2 1 | 2 1.5| Pigmentation | 3 3 3 3 3 3 2 | 11 2.9| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Developmental Malformation | X | 2 | Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 | 36 2.0| Hemorrhage | | 1 3.0| Pigmentation, Hemosiderin | 2 2 3 3 3 3 3 2 3 2 3 3 3 3 2 2| 35 2.6| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 1 3 1 1 1 1 2 2 1 1 | 20 1.4| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 | 4 2.3| Hyperkeratosis | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic | | 1 2.0| Ulcer | 4 | 2 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calvarium, Osteopetrosis | 3 | 1 3.0| Femur, Osteopetrosis | 4 | 2 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X X X X | 10 | Hydrocephalus | 2 2 | 4 2.0| Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 2 2.5| Edema | | 2 2.0| Foreign Body | 1 | 2 1.5| Infiltration Cellular, Histiocyte | 1 2 1 | 9 1.2| Inflammation, Subacute | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 3 1 2 2 | 4 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X X X X | 10 | Foreign Body | | 4 1.8| Mucosa, Hyperplasia | | 1 2.0| Mucosa, Metaplasia, Squamous | | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | Cataract | 3 | 1 3.0| Phthisis Bulbi | | 1 | Retina, Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Concretion | 3 2 3 1 2 1 2 2 2 2 1 2 2 2 4 2 | 34 1.9| Hydronephrosis | 2 4 3 | 3 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| | | 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Infarct | 2 2 | 2 2.0| Inflammation, Suppurative | | 1 2.0| Mineralization | 1 3 2 2 3 1 2 3 2 2 2 2 2 2 1 2 3 2 2 2 2 1 2| 43 1.9| Nephropathy | 1 2 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 2 1 1| 41 1.2| Renal Tubule, Dilatation | 3 | 1 3.0| Renal Tubule, Hyperplasia | | 1 2.0| Renal Tubule, Pigmentation | | 2 3.0| Transitional Epithelium, Hyperplasia | 3 1 3 3 1 1 2 1 1 1 3 1 | 23 1.5| __________________________________________________________________________|____________| Ureter | + + | 2 | Concretion | 4 | 1 4.0| Mucosa, Hyperplasia | 3 4 | 2 3.5| __________________________________________________________________________|____________| Urethra | + | 1 | Mucosa, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Concretion | 4 | 1 4.0| Mucosa, Hyperplasia | 3 4 4 | 4 3.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3| | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X | Cyst | X | Eosinophilic Focus | X X X X X X | Granuloma | 1 | Hematopoietic Cell Proliferation | 2 | Hepatodiaphragmatic Nodule | X X X X | Inflammation, Chronic | 1 | Mixed Cell Focus | X X X X X X | Bile Duct, Hyperplasia | 1 1 1 | Centrilobular, Atrophy | 2 3 | Lobules, Necrosis | 2 4 2 | __________________________________________________________________________| Mesentery | + + +| Fat, Hemorrhage | 2 | Fat, Necrosis | 3 2 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 1 1 1 1| Metaplasia, Hepatocyte | | Acinar Cell, Basophilic Focus | | Acinar Cell, Cytoplasmic Alteration | 3 3 | Acinar Cell, Hyperplasia, Focal | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Ulcer | | Mucosa, Hyperplasia | 2 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3| | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 1 1 2 1 2 | Inflammation, Subacute | 2 | Necrosis | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X X X X X | Angiectasis | 2 | Degeneration, Fatty | 1 1 1 | Hyperplasia, Focal | | Hypertrophy, Focal | 2 | Necrosis | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 2 1 3 1 | Pars Distalis, Cyst | X X X X X X | Pars Distalis, Hyperplasia, Focal | 1 1 3 1 3 | Pars Distalis, Hyperplasia | 3 | Pars Intermedia, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | | C-Cell, Hyperplasia | 3 1 | Follicular Cell, Hyperplasia | 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 3 2 2 2 2 4 3 2 3 3 3 3 | Hyperplasia | 2 | Inflammation, Chronic | 2 4 | Inflammation, Suppurative | 2 2 1 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 4| __________________________________________________________________________| Vagina | M | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3| | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hypercellularity | 2 2 | __________________________________________________________________________| Lymph Node | + + + + + + | Iliac, Ectasia | 3 | Iliac, Hyperplasia, Lymphoid | 3 | Mediastinal, Congestion | 3 | Mediastinal, Hemorrhage | 2 2 | Mediastinal, Pigmentation | 3 3 | Pancreatic, Hemorrhage | 2 | Pancreatic, Hyperplasia, Lymphoid | 2 | Renal, Hemorrhage | 1 | Renal, Hyperplasia, Lymphoid | 2 | Renal, Pigmentation | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Ectasia | 2 | Hemorrhage | 1 1 | Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 3 2 1 | Pigmentation | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 4 2 3 2 2 2 2 2 2 2 2 2 2 2 | Necrosis | 2 | Pigmentation, Hemosiderin | 3 2 3 3 2 3 3 3 3 3 3 3 3 2 3 2| Lymphoid Follicle, Atrophy | 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | Hemorrhage | 2 2 | Cortex, Atrophy | | Epithelial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 1 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Inflammation, | | Subacute | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3| | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Compression | X X X X | Hemorrhage | 2 | Mineralization | | Necrosis | 1 | __________________________________________________________________________| Peripheral Nerve | + + | __________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Edema | | Foreign Body | 2 3 | Hemorrhage | 3 1 | Infiltration Cellular, Histiocyte | 3 1 1 3 1 1 | Inflammation, Subacute | 2 | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X X | Foreign Body | 2 | Mucosa, Hyperplasia | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 4 | Retina, Atrophy | 4 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Concretion | 3 3 3 2 2 3 3 4 3 3 3 3 2 4 3 3 4 2 4 2 | Cyst | | Hemorrhage | 3 | Hydronephrosis | 2 3 3 1 1 2 3 | Infarct | | Inflammation, Suppurative | 1 | Mineralization | 3 3 2 1 2 1 3 1 2 2 1 1 2 3 2 1 2 2 2 1| Nephropathy | 1 4 2 2 1 1 2 2 1 1 1 1 3 2 3 3 1 1 1 1 1 1| Papilla, Necrosis | 2 | Renal Tubule, Cytoplasmic Alteration | 3 | Renal Tubule, Dilatation | 2 2 3 3 2 | Transitional Epithelium, Hyperplasia | 2 3 3 1 3 3 3 3 3 3 3 2 3 3 4 3 4 4 2 2 3 2 | __________________________________________________________________________| Ureter | + + + | Concretion | 2 3 | Mucosa, Hyperplasia | 3 3 3 | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3| | 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urethra | M | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Hyperplasia | 2 2 1 2 2 3 | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| | DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| | | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 7 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 3.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 40 | Clear Cell Focus | X X X X X X | 8 | Cyst | | 1 | Eosinophilic Focus | X X X X X X X | 13 | Granuloma | 1 1 | 3 1.0| Hematopoietic Cell Proliferation | 2 | 2 2.0| Hepatodiaphragmatic Nodule | | 4 | Inflammation, Chronic | | 1 1.0| Mixed Cell Focus | | 6 | Bile Duct, Hyperplasia | 1 | 4 1.0| Centrilobular, Atrophy | | 2 2.5| Lobules, Necrosis | | 3 2.7| __________________________________________________________________________|____________| Mesentery | + | 4 | Fat, Hemorrhage | | 1 2.0| Fat, Necrosis | 3 | 4 2.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 1 2 1 2 1 | 15 1.1| Metaplasia, Hepatocyte | X | 1 | Acinar Cell, Basophilic Focus | X X X | 3 | Acinar Cell, Cytoplasmic Alteration | 2 3 | 4 2.8| Acinar Cell, Hyperplasia, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | | 1 2.0| Ulcer | 2 | 1 2.0| Mucosa, Hyperplasia | 3 | 3 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| | DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| | | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 1 2 1 | 9 1.3| Inflammation, Subacute | 2 | 2 2.0| Necrosis | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X X X X | 16 | Angiectasis | 3 | 2 2.5| Degeneration, Fatty | 3 1 2 1 | 7 1.4| Hyperplasia, Focal | 1 1 1 1 1 | 5 1.0| Hypertrophy, Focal | 4 1 1 | 4 2.0| Necrosis | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + M + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 4 3 4 2 3 | 10 2.5| Pars Distalis, Cyst | X X X X X X X X X | 15 | Pars Distalis, Hyperplasia, Focal | 1 2 3 2 2 3 3 | 12 2.1| Pars Distalis, Hyperplasia | | 1 3.0| Pars Intermedia, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | X | 1 | C-Cell, Hyperplasia | 1 1 1 1 | 6 1.3| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 3 2 2 | 18 2.6| Hyperplasia | 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| | DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| | | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic | 2 2 2 2 | 6 2.3| Inflammation, Suppurative | 2 2 3 | 7 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X | 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 2 | 2 3.0| __________________________________________________________________________|____________| Vagina | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypercellularity | | 2 2.0| __________________________________________________________________________|____________| Lymph Node | + | 7 | Iliac, Ectasia | | 1 3.0| Iliac, Hyperplasia, Lymphoid | | 1 3.0| Mediastinal, Congestion | | 1 3.0| Mediastinal, Hemorrhage | 2 | 3 2.0| Mediastinal, Pigmentation | 4 | 3 3.3| Pancreatic, Hemorrhage | | 1 2.0| Pancreatic, Hyperplasia, Lymphoid | | 1 2.0| Renal, Hemorrhage | | 1 1.0| Renal, Hyperplasia, Lymphoid | | 1 2.0| Renal, Pigmentation | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Ectasia | | 1 2.0| Hemorrhage | | 2 1.0| Pigmentation | 2 2 2 2 2 3 | 7 2.1| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 1 | 6 1.8| Pigmentation | 3 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 1 2 2 3 2 3 2 2 2 2 2 2 | 29 2.2| Necrosis | | 1 2.0| Pigmentation, Hemosiderin | 3 2 2 3 3 2 3 2 3 2 3 3 3 3 3 2 3 2 2 3 3| 37 2.7| Lymphoid Follicle, Atrophy | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 4.0| Hemorrhage | 3 2 2 2| 6 2.2| Cortex, Atrophy | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| | DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| | | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Epithelial Cell, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + + + + + + + + + + M + + + + +| 48 | Ectasia | 2 1 | 4 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Inflammation, | | | Subacute | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | | 4 | Hemorrhage | | 1 2.0| Mineralization | 1 | 1 1.0| Necrosis | | 1 1.0| __________________________________________________________________________|____________| Peripheral Nerve | | 2 | __________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 3 2 3 3 3| 7 2.9| Edema | 2 2 3 2| 4 2.3| Foreign Body | 3 3 3 3 2 2 | 8 2.6| Hemorrhage | | 2 2.0| Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 2 | 13 1.5| Inflammation, Subacute | 2 | 2 2.0| Alveolar Epithelium, Hyperplasia | 3 1 | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X X | 5 | Foreign Body | 2 | 2 2.0| Mucosa, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| | DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| | | 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Cataract | | 2 3.5| Retina, Atrophy | | 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Concretion | 3 3 2 4 3 1 2 3 3 4 3 3 4 3 2 3 3 | 37 2.9| Cyst | X | 1 | Hemorrhage | | 1 3.0| Hydronephrosis | 2 1 2 | 10 2.0| Infarct | 2 3 2 | 3 2.3| Inflammation, Suppurative | 1 | 2 1.0| Mineralization | 2 1 1 1 1 2 1 2 1 1 1 2 3 2 2 1 2 2 3 2 3 | 41 1.8| Nephropathy | 1 2 1 2 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.4| Papilla, Necrosis | | 1 2.0| Renal Tubule, Cytoplasmic Alteration | | 1 3.0| Renal Tubule, Dilatation | 2 | 6 2.3| Transitional Epithelium, Hyperplasia | 2 2 3 1 3 3 3 1 3 3 3 3 3 4 2 1 4 2 1 2 2 | 43 2.6| __________________________________________________________________________|____________| Ureter | + | 4 | Concretion | | 2 2.5| Mucosa, Hyperplasia | 1 | 4 2.5| __________________________________________________________________________|____________| Urethra | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mucosa, Hyperplasia | 1 1 2 2 1 1 | 12 1.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X X X X X X X X X X X X X X X | Congestion | 3 | Degeneration, Cystic | 1 1 | Eosinophilic Focus | X | Hepatodiaphragmatic Nodule | X X X X | Mixed Cell Focus | X | Bile Duct, Hyperplasia | 3 2 2 3 3 2 3 2 1 2 4 2 1 1 1 1 2 2 1 2 1 2 3 2| Centrilobular, Atrophy | 3 3 | Hepatocyte, Vacuolization Cytoplasmic| 3 3| __________________________________________________________________________| Mesentery | + + + + + + | Fat, Necrosis | 3 2 4 4 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 3 1 1 2 1 1 2 1 1 | Acinar Cell, Basophilic Focus | X | Acinar Cell, Cytoplasmic Alteration | 3| Acinar Cell, Hyperplasia, Focal | 3 4 3 4 3 2 3 2 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Ulcer | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Embolus | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 3 2 1 1 3 3 2 2 2 2| Pericardium, Fibrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X X X X| Congestion | 4 | Cyst | X | Degeneration, Fatty | 3 1 3 2 | Hemorrhage | 2 | Hyperplasia, Focal | 1 1 | Hypertrophy, Focal | 3 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 3 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M M M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Pars Distalis, Angiectasis | 3 1 | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia, Focal | 3 2 1 1 2 2 2| Pars Intermedia, Cyst | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 1 1 1 1 2 1 | Follicle, Cyst | X | Follicular Cell, Hyperplasia | | Follicular Cell, Hypertrophy | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | X X X X X X X X X X X X X| Hypospermia | X X X X X X X X X X X X X X X X X X X X X X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 3 3 3 3 3 3 4 2 3 3 3 | Hyperplasia | | Inflammation, Chronic | 2 3 2 2 2 2 2 2 2 3 3 2| Inflammation, Suppurative | 1 3 3 2 2 3 3 2 2 2 2 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Corpora Amylacea | 2 2 2 2 3 2 3 2 2 2 2 2 3 2 2 2 | Hyperplasia, Lymphoid | | Inflammation, Suppurative | 3 1 3 1 1 1 2 1 3 | Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypercellularity | | __________________________________________________________________________| Lymph Node | + + + + + | Mediastinal, Hemorrhage | 4 2 3 2 | Mediastinal, Pigmentation | 4 2 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 | Hemorrhage | 1 2 1 1 | Hyperplasia, Lymphoid | 2 2 3 | Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 2 3 3 | Hematopoietic Cell Proliferation | 1 2 2 2 | Pigmentation, Hemosiderin | 3 2 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + + + + M + + + + + +| Hyperplasia, Cystic | 4 2 3 | Hyperplasia, Lobular | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Hemorrhage | | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X | Hydrocephalus | 2 | Mineralization | | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2| | 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Infiltration Cellular, Histiocyte | 1 1 | Inflammation, Subacute | 2 | Alveolar Epithelium, Hyperplasia | 1 2 3 1 | Fat, Mediastinum, Necrosis | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X X X X X X X | Foreign Body | 1 | Fungus | X X X | Mucosa, Hyperplasia | 2 2 2 | Mucosa, Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Suppurative | 1 1 1 | Mineralization | 1 1 | Nephropathy | 1 2 1 1 2 2 1 1 1 3 3 2 2 1 2 1 2 1 2 1 1 2 2 2| Renal Tubule, Pigmentation | 3 | Transitional Epithelium, Hyperplasia | 1 2 1 1 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| | | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L | | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X | 7 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X | 33 | Clear Cell Focus | X X X X X X X X X X X X X X | 32 | Congestion | | 1 3.0| Degeneration, Cystic | 1 1| 4 1.0| Eosinophilic Focus | X X X X X X | 7 | Hepatodiaphragmatic Nodule | X | 5 | Mixed Cell Focus | X X X X | 5 | Bile Duct, Hyperplasia | 1 1 2 2 1 2 1 1 1 1 1 1 2 1 2 1 1 2 3 3 3| 45 1.8| Centrilobular, Atrophy | 2 | 3 2.7| Hepatocyte, Vacuolization Cytoplasmic| | 2 3.0| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + | 17 | Fat, Necrosis | 4 4 3 2 3 3 3 3 2 | 14 3.1| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 1 1 1 2 1 1 3 | 18 1.4| Acinar Cell, Basophilic Focus | | 1 | Acinar Cell, Cytoplasmic Alteration | | 1 3.0| Acinar Cell, Hyperplasia, Focal | 2 2 2 2 2 2 3 | 16 2.6| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Erosion | | 1 2.0| Ulcer | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Embolus | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| | | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L | | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 3 2 2 2 2 2 3 3 3 3 1 | 23 2.2| Pericardium, Fibrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X X X X X X X X| 19 | Congestion | | 1 4.0| Cyst | | 1 | Degeneration, Fatty | 1 1 2 1 | 8 1.8| Hemorrhage | 2 | 2 2.0| Hyperplasia, Focal | 3 1 | 4 1.5| Hypertrophy, Focal | 2 2 | 5 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 1 2 1 2 3 1 2| 15 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Pars Distalis, Angiectasis | 3 3 | 4 2.5| Pars Distalis, Cyst | X X X | 5 | Pars Distalis, Hyperplasia, Focal | 1 3 1 2 1 2 3 2 | 15 1.9| Pars Intermedia, Cyst | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | | 1 | C-Cell, Hyperplasia | 2 1 1 1 1 1 1 3 | 14 1.3| Follicle, Cyst | | 1 | Follicular Cell, Hyperplasia | 2 | 1 2.0| Follicular Cell, Hypertrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atypia Cellular | X X X X X X X X X X X X| 25 | Hypospermia | X X X X X X X X X X X X X X X X X X| 40 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 3 2 3 4 4 3 | 20 3.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| | | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L | | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hyperplasia | 3 | 1 3.0| Inflammation, Chronic | 2 2 3 3 2 2 3 2 3 2 2 3| 24 2.3| Inflammation, Suppurative | 2 2 2 3 3 2 | 19 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Corpora Amylacea | 2 2 2 2 2 3 2 2 2 2 2 2| 28 2.1| Hyperplasia, Lymphoid | 2 | 1 2.0| Inflammation, Suppurative | 2 3 3 3 2 1 2 1 | 17 1.9| Epithelium, Hyperplasia | 1 2 2 1 1 1 | 8 1.3| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypercellularity | 2 4 3 | 3 3.0| __________________________________________________________________________|____________| Lymph Node | + + + +| 9 | Mediastinal, Hemorrhage | 3 3 | 6 2.8| Mediastinal, Pigmentation | 3 2 | 5 2.8| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 2 | 5 2.0| Hemorrhage | | 4 1.3| Hyperplasia, Lymphoid | 2 2 | 5 2.2| Hyperplasia, Plasma Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 2 1 | 3 1.3| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 4 3 2 2 | 8 2.8| Hematopoietic Cell Proliferation | 2 3 2 1 2 2 2 2 2 2 | 14 1.9| Pigmentation, Hemosiderin | 2 2 2 2 2 2 1 2 2 2 1 | 14 1.9| __________________________________________________________________________|____________| Thymus | + M + + + + I + + + + I + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Cystic | 2 1 3 2 2 2 2 2 | 11 2.3| Hyperplasia, Lobular | 2 | 2 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| | | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L | | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X | 4 | Hydrocephalus | | 1 2.0| Mineralization | 3 | 1 3.0| Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 8 1.0| Inflammation, Subacute | 3 2 | 3 2.3| Alveolar Epithelium, Hyperplasia | 1 2 1 3 3 3 | 10 2.0| Fat, Mediastinum, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X X X X X X X | 15 | Foreign Body | 2 2 1 | 4 1.5| Fungus | X X X | 6 | Mucosa, Hyperplasia | 2 2 1 | 6 1.8| Mucosa, Metaplasia, Squamous | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Inflammation, Suppurative | 1 1 1 | 6 1.0| Mineralization | 1 | 3 1.0| Nephropathy | 1 1 1 1 2 1 2 1 2 3 2 3 1 2 2 1 3 2 2 1 1 1 1 2| 48 1.6| Renal Tubule, Pigmentation | 2 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| | | 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L | | 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Transitional Epithelium, Hyperplasia | 1 1 1 1| 10 1.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3| | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + I + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + I + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X | Clear Cell Focus | X X X X X X X X X X X X X| Degeneration, Cystic | 3 | Eosinophilic Focus | X X X X X X| Hematopoietic Cell Proliferation | 2 2 | Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X X | Bile Duct, Hyperplasia | 2 1 3 2 1 1 2 3 2 2 3 1 2 1 2 1 2 2 2| Centrilobular, Atrophy | 2 3 | Centrilobular, Necrosis | 3 | Hepatocyte, Vacuolization Cytoplasmic| | Lobules, Necrosis | | __________________________________________________________________________| Mesentery | + + + + +| Accessory Spleen | X | Fat, Hemorrhage | | Fat, Necrosis | 3 3 3 2| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 1 4 1 1 1 1 1 3 3 2 1 1| Acinar Cell, Basophilic Focus | | Acinar Cell, Cytoplasmic Alteration | | Acinar Cell, Hyperplasia, Focal | 3 3 3 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 3 2 2 2 3 1 1 2 3 2 3 2 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3| | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X X X X X X X X | Congestion | | Degeneration, Fatty | 2 1 3 2 | Hematopoietic Cell Proliferation | | Hyperplasia, Focal | 1 1 | Hypertrophy, Focal | 1 | Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia | 2 3 1 2 2 2 1 1 2 1 1 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia, Focal | 1 3 1 | Pars Intermedia, Angiectasis | 2 3| Pars Intermedia, Cyst | X | Pars Intermedia, Hyperplasia | | Pars Nervosa, Gliosis | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X X X | C-Cell, Hyperplasia | 1 1 3 3 | Follicle, Cyst | | Follicular Cell, Hypertrophy | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | X X X X X X X X X X X X X X X X| Hypospermia | X X X X X X X X X X X X X X X X X X| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 2 3 2 4 3| Inflammation, Chronic | 2 2 2 1 2 2 2 2 2 2 2 3| Inflammation, Suppurative | 2 4 1| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Corpora Amylacea | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2| Inflammation, Suppurative | 2 1 1 2 2 1 2 3 3 2 3 3 1 | Epithelium, Hyperplasia | 2 1 1 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3| | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Dilatation | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 4 1 1 | Seminiferous Tubule, Atrophy | 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + +| Mediastinal, Hemorrhage | 3 3 3 3| Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Pigmentation | 4 3 3 3| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 3| Hemorrhage | 1 2 1 2 | Hyperplasia, Lymphoid | 2 2 | Pigmentation | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Pigmentation | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | | Fibrosis | 3 3 3 | Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 | Pigmentation, Hemosiderin | 2 2 2 1 1 2 3 1| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 3 3 2 2 | Hyperplasia, Lobular | 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X X X | Foreign Body | 3 | Inflammation, Suppurative | 3 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X | Hydrocephalus | 2 2 | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3| | 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 3 3 | Edema | 2 2 | Foreign Body | 2 1 2 3 | Hemorrhage | | Infiltration Cellular, Histiocyte | 1 1 | Inflammation, Subacute | 2 1 1 | Inflammation, Suppurative | | Alveolar Epithelium, Hyperplasia | | Fat, Mediastinum, Necrosis | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X | Foreign Body | 2 | Fungus | | Mucosa, Hyperplasia | | Mucosa, Metaplasia, Squamous | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 4 | Retina, Atrophy | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Concretion | | Cyst | X | Hemorrhage | | Hydronephrosis | | Inflammation, Suppurative | 1 1 1 2 1 | Mineralization | 1 1 1 1 1 | Nephropathy | 2 3 1 2 2 3 2 1 1 1 3 3 2 2 2 3 1 2 2 3 2 1 1 2| Renal Tubule, Dilatation | | Renal Tubule, Hyperplasia, Oncocytic | 2 | Renal Tubule, Pigmentation | 2 3 3 | Transitional Epithelium, Hyperplasia | 1 1 1 1 1 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Hemorrhage | | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| | | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X| 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 2| 2 1.5| Basophilic Focus | X X X X X X X X X X X X X X X X X X| 33 | Clear Cell Focus | X X X X X X X X X X| 23 | Degeneration, Cystic | | 1 3.0| Eosinophilic Focus | X X X X | 10 | Hematopoietic Cell Proliferation | 2 | 3 2.0| Hepatodiaphragmatic Nodule | X | 2 | Mixed Cell Focus | X | 3 | Bile Duct, Hyperplasia | 2 1 1 3 3 2 1 1 1 1 2 3 1 1 1 1 1 3 2 1| 39 1.7| Centrilobular, Atrophy | 2 3 | 4 2.5| Centrilobular, Necrosis | | 1 3.0| Hepatocyte, Vacuolization Cytoplasmic| 2 | 1 2.0| Lobules, Necrosis | 2 1 | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 14 | Accessory Spleen | | 1 | Fat, Hemorrhage | 2 | 1 2.0| Fat, Necrosis | 4 3 3 4 4 2 2 3 2 | 13 2.9| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 1 1 3 1 3 1 1 3 1 2 1| 26 1.7| Acinar Cell, Basophilic Focus | X | 1 | Acinar Cell, Cytoplasmic Alteration | 3 | 1 3.0| Acinar Cell, Hyperplasia, Focal | 3 2 4 2 3 2 2 | 11 2.8| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| | | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 3 2 2 2 3 3 1 2 1 2 1 1 2 1 | 27 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | X X X X X X X X X X X | 19 | Congestion | 3 | 1 3.0| Degeneration, Fatty | 2 1 | 6 1.8| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia, Focal | 1 1 1 1 1 1 | 8 1.0| Hypertrophy, Focal | 2 | 2 1.5| Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 1 2 3 1 1 | 18 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | | 1 2.0| Pars Distalis, Cyst | | 2 | Pars Distalis, Hyperplasia, Focal | 2 1 1 1 3 2 1 1 | 11 1.5| Pars Intermedia, Angiectasis | | 2 2.5| Pars Intermedia, Cyst | | 1 | Pars Intermedia, Hyperplasia | 1 | 1 1.0| Pars Nervosa, Gliosis | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | X | 4 | C-Cell, Hyperplasia | 1 1 1 1 1| 9 1.4| Follicle, Cyst | X X X | 3 | Follicular Cell, Hypertrophy | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atypia Cellular | X X X X X X X X X X X X X X X X X| 33 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| | | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hypospermia | X X X X X X X X X X X X X X X X| 34 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 4 3 3 3 2 2 3 4 3 | 17 2.9| Inflammation, Chronic | 3 2 2 3 2 2 | 18 2.1| Inflammation, Suppurative | 2 4 2 2 2 2 2 3 3 2 4 2 | 15 2.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Corpora Amylacea | 2 3 2 3 3 2 2 2 2 3 2 2 | 28 2.2| Inflammation, Suppurative | 3 2 1 3 3 1 | 19 2.1| Epithelium, Hyperplasia | 3 2 2 1 | 8 1.8| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | | 1 3.0| __________________________________________________________________________|____________| Testes | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Interstitial Cell, Hyperplasia | 1 | 5 1.6| Seminiferous Tubule, Atrophy | | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myelofibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 15 | Mediastinal, Hemorrhage | 2 2 2 2 | 8 2.5| Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0| Mediastinal, Pigmentation | 3 3 2 2 2 | 9 2.8| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 3 2.3| Hemorrhage | 1 1 2 2 | 8 1.5| Hyperplasia, Lymphoid | 3 2 | 4 2.3| Pigmentation | 2 2 | 3 2.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 2 2.5| Pigmentation | 3 | 2 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Developmental Malformation | X | 1 | Fibrosis | 4 4 3 3 2 | 8 3.1| Hematopoietic Cell Proliferation | 4 2 2 2 2 2 2 | 15 2.2| Pigmentation, Hemosiderin | 3 3 2 1 2 2 2 | 15 1.9| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95 Route: GAVAGE Time: 00:41:54 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| | | 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _______________________________________