TDMS Study 05099-07 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
SALICYLAZOSULFAPYRIDINE
NTP Experiment-Test: 05099-07 Report: PEIRPT09
Study Type: CHRONIC Date: 04/07/95
Route: GAVAGE Time: 00:41:54
CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 599-79-1
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 0 MG/KG
Include 003 84 MG/KG
Include 004 84 MG/KG
Include 005 168 MG/KG
Include 006 168 MG/KG
Include 007 337.5 MG/KG
Include 008 337.5 MG/KG
Page 1
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|
| 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Subacute | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X|
Granuloma | 1 1 1 1 3 1|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X X X X X |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 |
Centrilobular, Atrophy | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 4 1 2 |
Kupffer Cell, Pigmentation | 3 |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Accessory Spleen | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1 1 1 3 2 |
Metaplasia, Hepatocyte | X |
Acinar Cell, Cytoplasmic Alteration | 3 |
Acinar Cell, Hyperplasia, Focal | 2|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | |
Mucosa, Hyperplasia | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|
| 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Mucosa, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 |
Inflammation, Subacute | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X |
Cyst | |
Degeneration, Fatty | 1 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 1 2 |
Hypertrophy, Focal | 1 1 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 3 4 2 4 |
Pars Distalis, Cyst | X X X X X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 2 4 1 1 3 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 1 2 1 |
Follicle, Cyst | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 4 2 3 3 2 2|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|
| 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydrometra | |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | 2 3 2 |
Mediastinal, Pigmentation | 3 3 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 |
Pigmentation | 2 2 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hemorrhage | 4 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 2 3 2 2 2 2 1 2 3 3 3 2 3 2 3 3 3 2 3|
Lymphoid Follicle, Atrophy | |
Lymphoid Follicle, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 1 |
Hyperplasia, Lobular | 3 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|
| 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | 2 |
Femur, Osteopetrosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | |
Hydrocephalus | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Foreign Body | |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X |
Foreign Body | |
Fungus | |
Mucosa, Hyperplasia | 1 |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Retina, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Mineralization | 2 3 2 1 1 1 2 2 1 1 2 2 1 2 2 2 2 1 2 1 2|
Nephropathy | 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 9| 6| 3| 3| 3| 3| 9| 3| 3| 8| 3| 6| 3| 3|
| 8| 9| 8| 9| 9| 9| 8| 9| 2| 9| 8| 2| 0| 9| 9| 8| 9| 1| 9| 8| 4| 9| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 3 2 3 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + M + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| |
| 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Subacute | 2 | 1 2.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 45 |
Clear Cell Focus | X X X X X | 9 |
Eosinophilic Focus | X X X X X X X | 13 |
Granuloma | 1 1 1 1 1 1 3 3 1 | 15 1.4|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hepatodiaphragmatic Nodule | X X X X| 6 |
Mixed Cell Focus | X X X | 10 |
Bile Duct, Hyperplasia | 1 1 3 1 1 1 1 1 | 16 1.2|
Centrilobular, Atrophy | 2 2 | 4 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 4 2.3|
Kupffer Cell, Pigmentation | 1 4 | 3 2.7|
Lobules, Necrosis | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Accessory Spleen | X | 1 |
Fat, Necrosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 2 2 | 17 1.3|
Metaplasia, Hepatocyte | | 1 |
Acinar Cell, Cytoplasmic Alteration | 3 | 2 3.0|
Acinar Cell, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| |
| 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Ulcer | 4 | 1 4.0|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 2 1.5|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Mucosa, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 2 1 | 12 1.3|
Inflammation, Subacute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X| 13 |
Cyst | X | 1 |
Degeneration, Fatty | 1 1 2 4 | 5 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | 2 1 2 | 6 1.5|
Hypertrophy, Focal | 1 3 2 2 | 6 1.7|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 3.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 1 3 2 3 | 12 2.6|
Pars Distalis, Cyst | X X X X X X X X X X X X| 29 |
Pars Distalis, Hyperplasia, Focal | 3 3 2 2 3 | 11 2.4|
Pars Intermedia, Angiectasis | 3 3 | 2 3.0|
Pars Intermedia, Cyst | X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| |
| 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 3 2 1 | 7 1.7|
Follicle, Cyst | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 3 3 2 3 3 3 3| 17 2.8|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 2 2 3| 4 2.3|
Inflammation, Suppurative | 4 3| 4 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hydrometra | 2 2 2| 3 2.0|
Hyperplasia, Cystic | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Vagina | M | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 3 | 3 2.7|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 12 |
Mediastinal, Hemorrhage | 2 2 3 | 6 2.3|
Mediastinal, Pigmentation | 3 4 | 7 3.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 2 2 2| 7 2.1|
Hemorrhage | 1 1 | 3 1.3|
Hyperplasia, Lymphoid | 3 2 | 4 2.5|
Pigmentation | 2 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 2.0|
Pigmentation | 2 3 2 3 3 | 10 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 | 3 2.3|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 | 25 2.0|
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| |
| 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | 3 2 1 3 3 3 2 3 2 2 2 3 2 2 2 2 2 2 2| 38 2.3|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
Lymphoid Follicle, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 2 1 1 1 1 2 | 10 1.3|
Hyperplasia, Lobular | | 4 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 1.0|
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Osteopetrosis | 2 2 2 | 4 2.0|
Femur, Osteopetrosis | 2 4 2 4 | 5 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X | 10 |
Hemorrhage | 3 3 | 2 3.0|
Hydrocephalus | 2 2 | 3 2.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Edema | 2 | 1 2.0|
Foreign Body | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 1| 14 1.1|
Inflammation, Subacute | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 3| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 3| 2| 3| 3| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 0| 3| 3| |
| 9| 5| 8| 9| 9| 3| 2| 2| 9| 9| 9| 9| 9| 7| 8| 9| 9| 9| 8| 9| 3| 9| 7| 9| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X | 9 |
Foreign Body | 2 2 2 | 3 2.0|
Fungus | X | 1 |
Mucosa, Hyperplasia | 2 1 2 | 4 1.5|
Mucosa, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Retina, Atrophy | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Mineralization | 2 1 1 1 2 2 2 3 3 1 2 1 2 2 1 3 2 2 1 2 1 2 1 | 44 1.7|
Nephropathy | 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 | 34 1.1|
Renal Tubule, Dilatation | 2 | 2 2.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
Renal Tubule, Pigmentation | 2 2 2 2 | 8 2.3|
Transitional Epithelium, Hyperplasia | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Hyperplasia | 1 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|
| 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X X X X X X X |
Granuloma | 1 2 1 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | X X|
Bile Duct, Hyperplasia | 1 1 1 1 1 |
Centrilobular, Atrophy | 2 3 |
Hepatocyte, Vacuolization Cytoplasmic| |
Lobules, Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 3 1 1 1 1 1|
Metaplasia, Hepatocyte | |
Acinar Cell, Cytoplasmic Alteration | 3 |
Acinar Cell, Hyperplasia, Focal | 2 4 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
Erosion | 1 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|
| 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X|
Angiectasis | 2 3 3 |
Degeneration, Fatty | 1 1 2 4 1|
Hemorrhage | 3 |
Hyperplasia, Diffuse | 3 |
Hyperplasia, Focal | 1 1 1 1 |
Hypertrophy, Focal | 2 3 |
Necrosis | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Angiectasis | 2 3 2 1|
Pars Distalis, Cyst | X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 3 1 1 3 3 3 1 3 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 2 3 3 4 3 2 |
Hyperplasia | 1 4 |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2|
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 |
Hyperplasia, Cystic | 2 2 |
Endometrium, Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Myelofibrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|
| 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hemorrhage | 3 3 2 |
Mediastinal, Pigmentation | 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Ectasia | 2 2 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia, Plasma Cell | 3 |
Pigmentation | 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 1 4 |
Hyperplasia, Lymphoid | |
Pigmentation | 3 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 2 2 2 |
Pigmentation, Hemosiderin | 3 3 2 3 2 3 3 3 3 2 2 2 3 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 4 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | 2 |
Femur, Osteopetrosis | 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Compression | X X X X |
Hemorrhage | |
Hydrocephalus | 2 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 2| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 3| 3| 4| 4| 4| 3| 4| 1| 8| 4| 4| 3| 4| 9| 4| 3| 4| 3| 4| 3| 0| 4| 4| 4|
| 0| 8| 7| 0| 0| 8| 8| 0| 8| 3| 0| 0| 8| 0| 6| 0| 8| 0| 2| 0| 8| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
84 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
Foreign Body | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 3 |
Inflammation, Subacute | 1 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X|
Foreign Body | 2 2 2 1 |
Fungus | X X |
Mucosa, Hyperplasia | 2 2 |
Mucosa, Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Phthisis Bulbi | |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 3 1 1 1 2|
Cyst | |
Mineralization | 2 2 3 3 2 1 2 1 2 2 2 1 1 1 3 1 1 1 2 1 2 1 2|
Nephropathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 3 1 2 1 1 2 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Pigmentation | 2 2 |
Transitional Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| |
| 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X| 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 3 2.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | X X X | 7 |
Eosinophilic Focus | X X X X | 13 |
Granuloma | 1 1 1 | 8 1.1|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X X | 9 |
Mixed Cell Focus | X X X X X | 7 |
Bile Duct, Hyperplasia | 2 1 2 1 1 1 | 11 1.2|
Centrilobular, Atrophy | | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 1 4.0|
Lobules, Necrosis | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Necrosis | 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 2 2 1 1 | 16 1.4|
Metaplasia, Hepatocyte | X | 1 |
Acinar Cell, Cytoplasmic Alteration | 3 | 2 3.0|
Acinar Cell, Hyperplasia, Focal | | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 1.0|
Mucosa, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| |
| 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 | 11 1.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X | 8 |
Angiectasis | 3 4 | 5 3.0|
Degeneration, Fatty | 1 4 2 1 2 | 10 1.9|
Hemorrhage | | 1 3.0|
Hyperplasia, Diffuse | | 1 3.0|
Hyperplasia, Focal | 1 1 | 6 1.0|
Hypertrophy, Focal | 2 2| 4 2.3|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 5 2.0|
Pars Distalis, Cyst | X X X X X X X X X X X X X | 26 |
Pars Distalis, Hyperplasia, Focal | 4 3 1 1 | 13 2.2|
Pars Intermedia, Angiectasis | 3 2| 3 2.3|
Pars Intermedia, Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 1 1 1 | 10 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 4 3 2 3 3 4 | 15 2.9|
Hyperplasia | | 2 2.5|
Inflammation, Chronic | 2 2 2 3 2 2 | 15 2.1|
Inflammation, Suppurative | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X| 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| |
| 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 3 2.3|
Hyperplasia, Cystic | | 2 2.0|
Endometrium, Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Vagina | M + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 4 2 | 3 2.7|
Myelofibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + | 6 |
Mediastinal, Hemorrhage | 3 | 4 2.8|
Mediastinal, Pigmentation | 4 | 4 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Ectasia | 2 2 2 2 | 7 2.0|
Hemorrhage | 1 2 | 3 1.7|
Hyperplasia, Lymphoid | 2 3 2 | 5 2.4|
Hyperplasia, Plasma Cell | | 1 3.0|
Pigmentation | 2 3 2 3 2 2| 14 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 | 1 1.0|
Hemorrhage | 1 | 4 1.8|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation | 3 3 3 3 2| 9 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 3 3 2 2| 27 2.1|
Pigmentation, Hemosiderin | 2 3 1 2 2 2 3 4 2 3 2 3 2 2 2 2 2| 33 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X| 1 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 2 2 1 | 10 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| |
| 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Calvarium, Osteopetrosis | | 1 2.0|
Femur, Osteopetrosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Compression | X X X X X X X | 11 |
Hemorrhage | 3 2 | 2 2.5|
Hydrocephalus | 2 2 | 3 2.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 3 | 3 2.7|
Edema | 2 | 1 2.0|
Foreign Body | 1 2 | 2 1.5|
Hemorrhage | 1 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 2 1 3 | 13 1.5|
Inflammation, Subacute | 1 1 2 | 5 1.2|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 2 | 7 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X | 9 |
Foreign Body | 2 1 | 6 1.7|
Fungus | | 2 |
Mucosa, Hyperplasia | | 2 2.0|
Mucosa, Metaplasia, Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 5 |
Cataract | 2 4 | 3 3.0|
Phthisis Bulbi | X X | 2 |
Retina, Atrophy | 4 | 2 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 7| 3| 7| 7| 7| 7| 2| 7| 7| 7| 7| |
DAY ON TEST | 3| 4| 7| 9| 3| 4| 3| 0| 1| 4| 3| 4| 8| 4| 3| 9| 4| 4| 3| 3| 8| 2| 3| 4| 4| |
| 8| 0| 2| 3| 8| 0| 8| 1| 7| 0| 2| 0| 4| 4| 8| 5| 0| 0| 8| 8| 0| 4| 7| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
84 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Concretion | 1 2 2 1 | 9 1.6|
Cyst | X | 1 |
Mineralization | 2 3 2 1 2 2 1 1 1 2 2 2 2 1 2 1 2 3 3 1 2 2 1 1| 47 1.7|
Nephropathy | 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1| 36 1.2|
Renal Tubule, Dilatation | 2| 2 2.0|
Renal Tubule, Hyperplasia | | 1 4.0|
Renal Tubule, Pigmentation | 3 2 2 2 | 6 2.2|
Transitional Epithelium, Hyperplasia | 1 1 2 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|
| 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + I + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Developmental Malformation | X |
Eosinophilic Focus | X X X X X X |
Granuloma | 1 1 2 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X X X X X |
Bile Duct, Hyperplasia | 2 1 3 1 1 1 1|
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 1 2 |
Metaplasia, Hepatocyte | X |
Acinar Cell, Cytoplasmic Alteration | 3 3 |
Acinar Cell, Hyperplasia, Focal | 4 2|
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 2 |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|
| 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X |
Angiectasis | 3 |
Cyst | X |
Degeneration, Fatty | 2 |
Hyperplasia, Focal | 1 1 |
Hypertrophy, Focal | 1 1 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 4 |
Pars Distalis, Cyst | X X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 3 2 3 3|
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 2 2 1 2 4 2 |
Follicle, Cyst | X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 2 2 3 2 2|
Hyperplasia | |
Inflammation, Chronic | 2 3 3 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2|
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Vagina | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|
| 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Pigmentation | 3 2 3 3 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 1 1 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 3 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pigmentation | 3 3 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hemorrhage | 3 |
Pigmentation, Hemosiderin | 2 2 3 3 3 3 2 3 2 2 3 4 2 3 2 3 2 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 1 1 2 2 1 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 1 2 |
Hyperkeratosis | |
Inflammation, Chronic | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | |
Femur, Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hydrocephalus | 2 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 2| 3| 9| 3| 3| 3| 0| 6| 3| 3| 1| 3| 3| 8| 4| 3| 3| 3|
| 9| 9| 8| 9| 9| 5| 2| 4| 8| 5| 9| 3| 8| 8| 7| 9| 8| 9| 9| 9| 7| 4| 8| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
168 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Edema | 2 2 |
Foreign Body | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X |
Foreign Body | 1 2 2 2 |
Mucosa, Hyperplasia | 2 |
Mucosa, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Phthisis Bulbi | X |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 1 1 2 2 1 3 2 1 1 2 1 3 2 2 2 1 2|
Hydronephrosis | |
Infarct | |
Inflammation, Suppurative | 2 |
Mineralization | 2 1 3 1 2 2 1 2 2 2 2 2 2 2 1 2 1 2 2 2|
Nephropathy | 1 1 1 1 3 1 2 1 1 1 2 1 3 1 1 1 1 1 1 1|
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Pigmentation | 2 4 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 2 1 1 2 1 1 1 |
__________________________________________________________________________|
Ureter | |
Concretion | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Urethra | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| |
| 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X| 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X| 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 3 4 4 | 7 2.3|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X| 47 |
Clear Cell Focus | X X X X X X | 11 |
Developmental Malformation | | 1 |
Eosinophilic Focus | X X X X X X X X X X X X X | 19 |
Granuloma | 1 1 | 5 1.2|
Hepatodiaphragmatic Nodule | X X X | 4 |
Mixed Cell Focus | X X X X X | 11 |
Bile Duct, Hyperplasia | 1 1 | 9 1.3|
Lobules, Necrosis | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + + +| 4 |
Fat, Necrosis | 3 3 2| 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 1 1 2 2 1 1 1 | 14 1.5|
Metaplasia, Hepatocyte | | 1 |
Acinar Cell, Cytoplasmic Alteration | 3 3 | 4 3.0|
Acinar Cell, Hyperplasia, Focal | 1 2 | 4 2.3|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Mucosa, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| |
| 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 2 2 1 3 1 1| 16 1.4|
Mineralization | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X | 10 |
Angiectasis | | 1 3.0|
Cyst | | 1 |
Degeneration, Fatty | 1 1 1 1 1| 6 1.2|
Hyperplasia, Focal | 1 1 1 1 1 1 1 | 9 1.0|
Hypertrophy, Focal | 1 | 5 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 3 2 | 7 2.6|
Pars Distalis, Cyst | X X X X X X X X X | 18 |
Pars Distalis, Hyperplasia, Focal | 3 2 1 2 3 2 2 2 | 12 2.3|
Pars Intermedia, Angiectasis | 2 | 1 2.0|
Pars Intermedia, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 3 |
C-Cell, Hyperplasia | 1 1 2 1 | 10 1.8|
Follicle, Cyst | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 3 2 4 2 3 3 | 17 2.5|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 2 2 2 2 2 | 8 2.3|
Inflammation, Suppurative | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| |
| 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 3 3 1| 5 2.4|
Hyperplasia, Cystic | 2 | 2 1.5|
__________________________________________________________________________|____________|
Vagina | M + | 1 |
Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 4 | 2 3.0|
Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + +| 9 |
Mediastinal, Ectasia | 2 | 1 2.0|
Mediastinal, Hemorrhage | 1 3| 3 1.7|
Mediastinal, Pigmentation | 3 3 4| 7 3.0|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 | 3 2.0|
Hemorrhage | | 2 1.0|
Hyperplasia, Lymphoid | 3 2 3 | 4 2.8|
Pigmentation | 2 | 6 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 1 | 2 1.5|
Pigmentation | 3 3 3 3 3 3 2 | 11 2.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 2 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 | 36 2.0|
Hemorrhage | | 1 3.0|
Pigmentation, Hemosiderin | 2 2 3 3 3 3 3 2 3 2 3 3 3 3 2 2| 35 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 3 1 1 1 1 2 2 1 1 | 20 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 4 2.3|
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| |
| 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
Ulcer | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Osteopetrosis | 3 | 1 3.0|
Femur, Osteopetrosis | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X | 10 |
Hydrocephalus | 2 2 | 4 2.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 2.5|
Edema | | 2 2.0|
Foreign Body | 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 2 1 | 9 1.2|
Inflammation, Subacute | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 1 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X | 10 |
Foreign Body | | 4 1.8|
Mucosa, Hyperplasia | | 1 2.0|
Mucosa, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 3 | 1 3.0|
Phthisis Bulbi | | 1 |
Retina, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | 3 2 3 1 2 1 2 2 2 2 1 2 2 2 4 2 | 34 1.9|
Hydronephrosis | 2 4 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 9| 9| 2| 3| 3| 0| 3| 3| 3| 3| 9| 3| 3| 3| 3| 4| 3| 9| 3| 3| 3| |
| 1| 9| 8| 9| 5| 6| 5| 8| 9| 8| 9| 3| 8| 9| 1| 8| 9| 3| 9| 0| 8| 1| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
168 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infarct | 2 2 | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 1 3 2 2 3 1 2 3 2 2 2 2 2 2 1 2 3 2 2 2 2 1 2| 43 1.9|
Nephropathy | 1 2 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 2 1 1| 41 1.2|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Pigmentation | | 2 3.0|
Transitional Epithelium, Hyperplasia | 3 1 3 3 1 1 2 1 1 1 3 1 | 23 1.5|
__________________________________________________________________________|____________|
Ureter | + + | 2 |
Concretion | 4 | 1 4.0|
Mucosa, Hyperplasia | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Mucosa, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | 4 | 1 4.0|
Mucosa, Hyperplasia | 3 4 4 | 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|
| 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Cyst | X |
Eosinophilic Focus | X X X X X X |
Granuloma | 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 |
Mixed Cell Focus | X X X X X X |
Bile Duct, Hyperplasia | 1 1 1 |
Centrilobular, Atrophy | 2 3 |
Lobules, Necrosis | 2 4 2 |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Hemorrhage | 2 |
Fat, Necrosis | 3 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1 1|
Metaplasia, Hepatocyte | |
Acinar Cell, Basophilic Focus | |
Acinar Cell, Cytoplasmic Alteration | 3 3 |
Acinar Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | |
Mucosa, Hyperplasia | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|
| 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 1 2 1 2 |
Inflammation, Subacute | 2 |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X X |
Angiectasis | 2 |
Degeneration, Fatty | 1 1 1 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
Necrosis | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 1 3 1 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia, Focal | 1 1 3 1 3 |
Pars Distalis, Hyperplasia | 3 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 1 |
Follicular Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 2 2 2 2 4 3 2 3 3 3 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 4 |
Inflammation, Suppurative | 2 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 4|
__________________________________________________________________________|
Vagina | M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|
| 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hypercellularity | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Ectasia | 3 |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Congestion | 3 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Pigmentation | 3 3 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hemorrhage | 1 |
Renal, Hyperplasia, Lymphoid | 2 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Ectasia | 2 |
Hemorrhage | 1 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 3 2 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 2 3 2 2 2 2 2 2 2 2 2 2 2 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 3 2 3 3 2 3 3 3 3 3 3 3 3 2 3 2|
Lymphoid Follicle, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 2 2 |
Cortex, Atrophy | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Subacute | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|
| 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | X X X X |
Hemorrhage | 2 |
Mineralization | |
Necrosis | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | |
Foreign Body | 2 3 |
Hemorrhage | 3 1 |
Infiltration Cellular, Histiocyte | 3 1 1 3 1 1 |
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X |
Foreign Body | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 4 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 3 3 3 2 2 3 3 4 3 3 3 3 2 4 3 3 4 2 4 2 |
Cyst | |
Hemorrhage | 3 |
Hydronephrosis | 2 3 3 1 1 2 3 |
Infarct | |
Inflammation, Suppurative | 1 |
Mineralization | 3 3 2 1 2 1 3 1 2 2 1 1 2 3 2 1 2 2 2 1|
Nephropathy | 1 4 2 2 1 1 2 2 1 1 1 1 3 2 3 3 1 1 1 1 1 1|
Papilla, Necrosis | 2 |
Renal Tubule, Cytoplasmic Alteration | 3 |
Renal Tubule, Dilatation | 2 2 3 3 2 |
Transitional Epithelium, Hyperplasia | 2 3 3 1 3 3 3 3 3 3 3 2 3 3 4 3 4 4 2 2 3 2 |
__________________________________________________________________________|
Ureter | + + + |
Concretion | 2 3 |
Mucosa, Hyperplasia | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 4| 7| 4| 5| 6| 4| 6| 7| 3| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7|
DAY ON TEST | 0| 3| 1| 6| 9| 9| 0| 3| 5| 3| 3| 0| 3| 3| 3| 0| 3| 3| 0| 0| 0| 3| 3| 9| 3|
| 5| 8| 6| 8| 6| 5| 7| 9| 8| 8| 9| 3| 9| 9| 9| 3| 3| 8| 9| 4| 8| 8| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
337.5 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urethra | M |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 2 2 1 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| |
DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| |
| 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 40 |
Clear Cell Focus | X X X X X X | 8 |
Cyst | | 1 |
Eosinophilic Focus | X X X X X X X | 13 |
Granuloma | 1 1 | 3 1.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hepatodiaphragmatic Nodule | | 4 |
Inflammation, Chronic | | 1 1.0|
Mixed Cell Focus | | 6 |
Bile Duct, Hyperplasia | 1 | 4 1.0|
Centrilobular, Atrophy | | 2 2.5|
Lobules, Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Hemorrhage | | 1 2.0|
Fat, Necrosis | 3 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 2 1 2 1 | 15 1.1|
Metaplasia, Hepatocyte | X | 1 |
Acinar Cell, Basophilic Focus | X X X | 3 |
Acinar Cell, Cytoplasmic Alteration | 2 3 | 4 2.8|
Acinar Cell, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Ulcer | 2 | 1 2.0|
Mucosa, Hyperplasia | 3 | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| |
DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| |
| 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 | 9 1.3|
Inflammation, Subacute | 2 | 2 2.0|
Necrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X X | 16 |
Angiectasis | 3 | 2 2.5|
Degeneration, Fatty | 3 1 2 1 | 7 1.4|
Hyperplasia, Focal | 1 1 1 1 1 | 5 1.0|
Hypertrophy, Focal | 4 1 1 | 4 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 4 3 4 2 3 | 10 2.5|
Pars Distalis, Cyst | X X X X X X X X X | 15 |
Pars Distalis, Hyperplasia, Focal | 1 2 3 2 2 3 3 | 12 2.1|
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 1 1 1 | 6 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 2 2 | 18 2.6|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| |
DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| |
| 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 2 2 2 | 6 2.3|
Inflammation, Suppurative | 2 2 3 | 7 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 2 3.0|
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Iliac, Ectasia | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Congestion | | 1 3.0|
Mediastinal, Hemorrhage | 2 | 3 2.0|
Mediastinal, Pigmentation | 4 | 3 3.3|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hemorrhage | | 1 1.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Ectasia | | 1 2.0|
Hemorrhage | | 2 1.0|
Pigmentation | 2 2 2 2 2 3 | 7 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 1 | 6 1.8|
Pigmentation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 1 2 2 3 2 3 2 2 2 2 2 2 | 29 2.2|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | 3 2 2 3 3 2 3 2 3 2 3 3 3 3 3 2 3 2 2 3 3| 37 2.7|
Lymphoid Follicle, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Hemorrhage | 3 2 2 2| 6 2.2|
Cortex, Atrophy | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| |
DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| |
| 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Epithelial Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + M + + + + +| 48 |
Ectasia | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
Subacute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 4 |
Hemorrhage | | 1 2.0|
Mineralization | 1 | 1 1.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 2 3 3 3| 7 2.9|
Edema | 2 2 3 2| 4 2.3|
Foreign Body | 3 3 3 3 2 2 | 8 2.6|
Hemorrhage | | 2 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 2 | 13 1.5|
Inflammation, Subacute | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X | 5 |
Foreign Body | 2 | 2 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 5| 7| 3| 3| 1| 3| |
DAY ON TEST | 9| 3| 3| 3| 1| 3| 3| 3| 3| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 0| 3| 4| 7| 2| 9| |
| 8| 8| 9| 8| 4| 9| 8| 9| 9| 5| 8| 8| 9| 8| 8| 9| 8| 9| 9| 8| 9| 9| 5| 2| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
337.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 2| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 3| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | | 2 3.5|
Retina, Atrophy | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | 3 3 2 4 3 1 2 3 3 4 3 3 4 3 2 3 3 | 37 2.9|
Cyst | X | 1 |
Hemorrhage | | 1 3.0|
Hydronephrosis | 2 1 2 | 10 2.0|
Infarct | 2 3 2 | 3 2.3|
Inflammation, Suppurative | 1 | 2 1.0|
Mineralization | 2 1 1 1 1 2 1 2 1 1 1 2 3 2 2 1 2 2 3 2 3 | 41 1.8|
Nephropathy | 1 2 1 2 2 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.4|
Papilla, Necrosis | | 1 2.0|
Renal Tubule, Cytoplasmic Alteration | | 1 3.0|
Renal Tubule, Dilatation | 2 | 6 2.3|
Transitional Epithelium, Hyperplasia | 2 2 3 1 3 3 3 1 3 3 3 3 3 4 2 1 4 2 1 2 2 | 43 2.6|
__________________________________________________________________________|____________|
Ureter | + | 4 |
Concretion | | 2 2.5|
Mucosa, Hyperplasia | 1 | 4 2.5|
__________________________________________________________________________|____________|
Urethra | | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia | 1 1 2 2 1 1 | 12 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|
| 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X X X X X X |
Congestion | 3 |
Degeneration, Cystic | 1 1 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | X |
Bile Duct, Hyperplasia | 3 2 2 3 3 2 3 2 1 2 4 2 1 1 1 1 2 2 1 2 1 2 3 2|
Centrilobular, Atrophy | 3 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3|
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 2 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 1 2 1 1 2 1 1 |
Acinar Cell, Basophilic Focus | X |
Acinar Cell, Cytoplasmic Alteration | 3|
Acinar Cell, Hyperplasia, Focal | 3 4 3 4 3 2 3 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 1 1 3 3 2 2 2 2|
Pericardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|
| 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X|
Congestion | 4 |
Cyst | X |
Degeneration, Fatty | 3 1 3 2 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 1 |
Hypertrophy, Focal | 3 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Pars Distalis, Angiectasis | 3 1 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 3 2 1 1 2 2 2|
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 1 1 2 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
Follicular Cell, Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X X X X X X X X|
Hypospermia | X X X X X X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 3 3 3 3 3 3 4 2 3 3 3 |
Hyperplasia | |
Inflammation, Chronic | 2 3 2 2 2 2 2 2 2 3 3 2|
Inflammation, Suppurative | 1 3 3 2 2 3 3 2 2 2 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 3 2 3 2 2 2 2 2 3 2 2 2 |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 3 1 3 1 1 1 2 1 3 |
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|
| 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hemorrhage | 4 2 3 2 |
Mediastinal, Pigmentation | 4 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hemorrhage | 1 2 1 1 |
Hyperplasia, Lymphoid | 2 2 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 3 3 |
Hematopoietic Cell Proliferation | 1 2 2 2 |
Pigmentation, Hemosiderin | 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + M + + + + + +|
Hyperplasia, Cystic | 4 2 3 |
Hyperplasia, Lobular | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 2 |
Mineralization | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 2| 3| 3| 1| 2| 3| 3| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 2| 3| 2| 2|
| 1| 9| 1| 1| 7| 9| 1| 2| 1| 0| 1| 1| 9| 1| 1| 1| 1| 9| 1| 1| 1| 9| 1| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 3 1 |
Fat, Mediastinum, Necrosis | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X X |
Foreign Body | 1 |
Fungus | X X X |
Mucosa, Hyperplasia | 2 2 2 |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Suppurative | 1 1 1 |
Mineralization | 1 1 |
Nephropathy | 1 2 1 1 2 2 1 1 1 3 3 2 2 1 2 1 2 1 2 1 1 2 2 2|
Renal Tubule, Pigmentation | 3 |
Transitional Epithelium, Hyperplasia | 1 2 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| |
| 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X X | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X | 33 |
Clear Cell Focus | X X X X X X X X X X X X X X | 32 |
Congestion | | 1 3.0|
Degeneration, Cystic | 1 1| 4 1.0|
Eosinophilic Focus | X X X X X X | 7 |
Hepatodiaphragmatic Nodule | X | 5 |
Mixed Cell Focus | X X X X | 5 |
Bile Duct, Hyperplasia | 1 1 2 2 1 2 1 1 1 1 1 1 2 1 2 1 1 2 3 3 3| 45 1.8|
Centrilobular, Atrophy | 2 | 3 2.7|
Hepatocyte, Vacuolization Cytoplasmic| | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 17 |
Fat, Necrosis | 4 4 3 2 3 3 3 3 2 | 14 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 1 2 1 1 3 | 18 1.4|
Acinar Cell, Basophilic Focus | | 1 |
Acinar Cell, Cytoplasmic Alteration | | 1 3.0|
Acinar Cell, Hyperplasia, Focal | 2 2 2 2 2 2 3 | 16 2.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Erosion | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| |
| 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 3 2 2 2 2 2 3 3 3 3 1 | 23 2.2|
Pericardium, Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X X X X X X| 19 |
Congestion | | 1 4.0|
Cyst | | 1 |
Degeneration, Fatty | 1 1 2 1 | 8 1.8|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Focal | 3 1 | 4 1.5|
Hypertrophy, Focal | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 2 1 2 3 1 2| 15 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Pars Distalis, Angiectasis | 3 3 | 4 2.5|
Pars Distalis, Cyst | X X X | 5 |
Pars Distalis, Hyperplasia, Focal | 1 3 1 2 1 2 3 2 | 15 1.9|
Pars Intermedia, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 1 1 1 1 1 1 3 | 14 1.3|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
Follicular Cell, Hypertrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | X X X X X X X X X X X X| 25 |
Hypospermia | X X X X X X X X X X X X X X X X X X| 40 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 2 3 4 4 3 | 20 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| |
| 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 2 2 3 3 2 2 3 2 3 2 2 3| 24 2.3|
Inflammation, Suppurative | 2 2 2 3 3 2 | 19 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 2 2 2 2 3 2 2 2 2 2 2| 28 2.1|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Suppurative | 2 3 3 3 2 1 2 1 | 17 1.9|
Epithelium, Hyperplasia | 1 2 2 1 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 2 4 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + +| 9 |
Mediastinal, Hemorrhage | 3 3 | 6 2.8|
Mediastinal, Pigmentation | 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 | 5 2.0|
Hemorrhage | | 4 1.3|
Hyperplasia, Lymphoid | 2 2 | 5 2.2|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 1 | 3 1.3|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 3 2 2 | 8 2.8|
Hematopoietic Cell Proliferation | 2 3 2 1 2 2 2 2 2 2 | 14 1.9|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 1 2 2 2 1 | 14 1.9|
__________________________________________________________________________|____________|
Thymus | + M + + + + I + + + + I + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Cystic | 2 1 3 2 2 2 2 2 | 11 2.3|
Hyperplasia, Lobular | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| |
| 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 4 |
Hydrocephalus | | 1 2.0|
Mineralization | 3 | 1 3.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 8 1.0|
Inflammation, Subacute | 3 2 | 3 2.3|
Alveolar Epithelium, Hyperplasia | 1 2 1 3 3 3 | 10 2.0|
Fat, Mediastinum, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X X | 15 |
Foreign Body | 2 2 1 | 4 1.5|
Fungus | X X X | 6 |
Mucosa, Hyperplasia | 2 2 1 | 6 1.8|
Mucosa, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Suppurative | 1 1 1 | 6 1.0|
Mineralization | 1 | 3 1.0|
Nephropathy | 1 1 1 1 2 1 2 1 2 3 2 3 1 2 2 1 3 2 2 1 1 1 1 2| 48 1.6|
Renal Tubule, Pigmentation | 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 3| 0| 3| 2| 3| 0| 3| 2| 3| 0| 7| 3| 3| 2| 5| 8| 7| 5| 3| 3| 2| 3| 7| 1| |
| 9| 1| 0| 1| 9| 1| 5| 1| 9| 1| 8| 3| 1| 1| 9| 3| 4| 6| 1| 1| 1| 9| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| L |
| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Transitional Epithelium, Hyperplasia | 1 1 1 1| 10 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|
| 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X|
Degeneration, Cystic | 3 |
Eosinophilic Focus | X X X X X X|
Hematopoietic Cell Proliferation | 2 2 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia | 2 1 3 2 1 1 2 3 2 2 3 1 2 1 2 1 2 2 2|
Centrilobular, Atrophy | 2 3 |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| |
Lobules, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + +|
Accessory Spleen | X |
Fat, Hemorrhage | |
Fat, Necrosis | 3 3 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 4 1 1 1 1 1 3 3 2 1 1|
Acinar Cell, Basophilic Focus | |
Acinar Cell, Cytoplasmic Alteration | |
Acinar Cell, Hyperplasia, Focal | 3 3 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 3 1 1 2 3 2 3 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|
| 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X X |
Congestion | |
Degeneration, Fatty | 2 1 3 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 1 |
Hypertrophy, Focal | 1 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 2 3 1 2 2 2 1 1 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 1 3 1 |
Pars Intermedia, Angiectasis | 2 3|
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | |
Pars Nervosa, Gliosis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X X |
C-Cell, Hyperplasia | 1 1 3 3 |
Follicle, Cyst | |
Follicular Cell, Hypertrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X X X X X X X X X X X|
Hypospermia | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 2 3 2 4 3|
Inflammation, Chronic | 2 2 2 1 2 2 2 2 2 2 2 3|
Inflammation, Suppurative | 2 4 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2|
Inflammation, Suppurative | 2 1 1 2 2 1 2 3 3 2 3 3 1 |
Epithelium, Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|
| 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 4 1 1 |
Seminiferous Tubule, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Mediastinal, Hemorrhage | 3 3 3 3|
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 4 3 3 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3|
Hemorrhage | 1 2 1 2 |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Pigmentation | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 3 3 3 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 |
Pigmentation, Hemosiderin | 2 2 2 1 1 2 3 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 3 2 2 |
Hyperplasia, Lobular | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X X |
Foreign Body | 3 |
Inflammation, Suppurative | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 2 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 0| 7| 7| 7| 7| 6| 7| 2| 7| 7| 7| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 2| 5| 3| 4| 3| 2| 3| 3| 2| 2| 3|
| 2| 9| 9| 2| 2| 2| 2| 4| 9| 2| 5| 2| 2| 2| 9| 4| 2| 3| 2| 9| 3| 3| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
84 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 |
Edema | 2 2 |
Foreign Body | 2 1 2 3 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Subacute | 2 1 1 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
Fat, Mediastinum, Necrosis | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X |
Foreign Body | 2 |
Fungus | |
Mucosa, Hyperplasia | |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Cyst | X |
Hemorrhage | |
Hydronephrosis | |
Inflammation, Suppurative | 1 1 1 2 1 |
Mineralization | 1 1 1 1 1 |
Nephropathy | 2 3 1 2 2 3 2 1 1 1 3 3 2 2 2 3 1 2 2 3 2 1 1 2|
Renal Tubule, Dilatation | |
Renal Tubule, Hyperplasia, Oncocytic | 2 |
Renal Tubule, Pigmentation | 2 3 3 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| |
| 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X| 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2| 2 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 33 |
Clear Cell Focus | X X X X X X X X X X| 23 |
Degeneration, Cystic | | 1 3.0|
Eosinophilic Focus | X X X X | 10 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hepatodiaphragmatic Nodule | X | 2 |
Mixed Cell Focus | X | 3 |
Bile Duct, Hyperplasia | 2 1 1 3 3 2 1 1 1 1 2 3 1 1 1 1 1 3 2 1| 39 1.7|
Centrilobular, Atrophy | 2 3 | 4 2.5|
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 1 2.0|
Lobules, Necrosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 14 |
Accessory Spleen | | 1 |
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | 4 3 3 4 4 2 2 3 2 | 13 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 1 1 3 1 3 1 1 3 1 2 1| 26 1.7|
Acinar Cell, Basophilic Focus | X | 1 |
Acinar Cell, Cytoplasmic Alteration | 3 | 1 3.0|
Acinar Cell, Hyperplasia, Focal | 3 2 4 2 3 2 2 | 11 2.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| |
| 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 2 2 2 3 3 1 2 1 2 1 1 2 1 | 27 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X X X X X X | 19 |
Congestion | 3 | 1 3.0|
Degeneration, Fatty | 2 1 | 6 1.8|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Focal | 1 1 1 1 1 1 | 8 1.0|
Hypertrophy, Focal | 2 | 2 1.5|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 2 3 1 1 | 18 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 1 1 3 2 1 1 | 11 1.5|
Pars Intermedia, Angiectasis | | 2 2.5|
Pars Intermedia, Cyst | | 1 |
Pars Intermedia, Hyperplasia | 1 | 1 1.0|
Pars Nervosa, Gliosis | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 4 |
C-Cell, Hyperplasia | 1 1 1 1 1| 9 1.4|
Follicle, Cyst | X X X | 3 |
Follicular Cell, Hypertrophy | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | X X X X X X X X X X X X X X X X X| 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| |
| 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hypospermia | X X X X X X X X X X X X X X X X| 34 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 4 3 3 3 2 2 3 4 3 | 17 2.9|
Inflammation, Chronic | 3 2 2 3 2 2 | 18 2.1|
Inflammation, Suppurative | 2 4 2 2 2 2 2 3 3 2 4 2 | 15 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 3 2 3 3 2 2 2 2 3 2 2 | 28 2.2|
Inflammation, Suppurative | 3 2 1 3 3 1 | 19 2.1|
Epithelium, Hyperplasia | 3 2 2 1 | 8 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 1 | 5 1.6|
Seminiferous Tubule, Atrophy | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 15 |
Mediastinal, Hemorrhage | 2 2 2 2 | 8 2.5|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Pigmentation | 3 3 2 2 2 | 9 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 3 2.3|
Hemorrhage | 1 1 2 2 | 8 1.5|
Hyperplasia, Lymphoid | 3 2 | 4 2.3|
Pigmentation | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.5|
Pigmentation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Fibrosis | 4 4 3 3 2 | 8 3.1|
Hematopoietic Cell Proliferation | 4 2 2 2 2 2 2 | 15 2.2|
Pigmentation, Hemosiderin | 3 3 2 1 2 2 2 | 15 1.9|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 00:41:54
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 6| 7| 6| 6| 7| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 6| 9| 2| 9| 6| 2| 1| 1| 2| 8| 0| 3| 3| 2| 3| 3| 0| 3| 2| 3| 3| 3| |
| 3| 6| 5| 0| 1| 9| 2| 2| 9| 5| 4| 9| 0| 5| 3| 3| 9| 3| 3| 9| 3| 9| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
84 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_______________________________________