TDMS Study 05101-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
METHYL BROMIDE
NTP Experiment-Test: 05101-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
Facility: Brookhaven National Laboratory
Chemical CAS #: 74-83-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 21 50 15 20 50 16
Scheduled Sacrifice 19 9 20 7
Early Deaths
Moribund Sacrifice 1 4 5 1
Dead 1 6 3 1
Moribund 3 1
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 36 6 41 7
Animals Examined Microscopically 20 50 20 50 2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (20) (46) (20) (49) (2)
Diverticulum 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%) 3 (15%) 7 (14%)
Intestine Small, Ileum (20) (49) (20) (50) (2)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (20) (48) (20) (49) (2)
Hyperplasia, Lymphoid 1 (2%)
Liver (20) (50) (20) (50) (2)
Basophilic Focus 3 (6%) 1 (2%)
Clear Cell Focus 3 (6%) 5 (10%)
Eosinophilic Focus 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 9 (45%) 7 (35%)
Infiltration Cellular, Lymphocyte 1 (5%) 11 (22%) 18 (36%) 1 (50%)
Inflammation 7 (14%) 1 (2%)
Mixed Cell Focus 2 (4%)
Necrosis, Focal 1 (5%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 1 (5%) 1 (5%)
Mesentery (2) (2)
Cyst 1 (50%)
Fat, Necrosis 1 (50%) 2 (100%)
Pancreas (20) (50) (20) (50) (2)
Degeneration 1 (5%)
Infiltration Cellular, Lymphocyte 4 (20%) 19 (38%) 3 (15%) 24 (48%)
Acinus, Atrophy 1 (2%) 2 (4%)
Acinus, Cyst 1 (2%)
Acinus, Hyperplasia 1 (50%)
Salivary Glands (20) (49) (20) (49) (2)
Infiltration Cellular, Lymphocyte 5 (25%) 35 (71%) 8 (40%) 25 (51%) 2 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (20) (50) (20) (50) (2)
Ulcer 1 (2%)
Stomach, Glandular (20) (50) (20) (50) (2)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (50) (20) (50) (2)
Cardiomyopathy, Chronic 2 (4%) 4 (8%)
Degeneration 1 (2%)
Embolus Bacterial 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (5%)
Inflammation, Acute 1 (2%)
Mineralization 1 (5%) 1 (2%)
Polyarteritis 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (19) (50) (20) (50) (2)
Spindle Cell, Hyperplasia 18 (95%) 47 (94%) 19 (95%) 49 (98%) 2 (100%)
Adrenal Gland, Cortex (19) (50) (20) (50) (2)
Amyloid Deposition 3 (6%) 5 (10%)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 3 (6%) 3 (6%)
Hypertrophy 2 (4%) 2 (4%)
Pigmentation 9 (18%) 6 (12%)
Vacuolization Cytoplasmic 4 (8%) 1 (5%) 2 (4%)
Spindle Cell, Hyperplasia 1 (2%)
Adrenal Gland, Medulla (19) (50) (20) (50) (2)
Hyperplasia 4 (8%) 1 (2%)
Islets, Pancreatic (20) (50) (20) (50) (2)
Hyperplasia 2 (4%)
Parathyroid Gland (16) (45) (19) (47) (2)
Cyst 3 (7%) 1 (2%)
Pituitary Gland (18) (49) (18) (48) (2)
Angiectasis 2 (4%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 6 (12%) 5 (10%)
Thyroid Gland (19) (49) (20) (49) (2)
Infiltration Cellular, Lymphocyte 2 (4%) 4 (8%)
Polyarteritis 1 (2%)
Follicular Cell, Hyperplasia 7 (14%) 10 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (20) (50) (20) (49) (2)
Cyst 8 (16%) 2 (10%) 10 (20%)
Infiltration Cellular, Lymphocyte 2 (4%)
Pigmentation 2 (4%)
Uterus (20) (50) (20) (50) (2)
Angiectasis 2 (4%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Endometrium, Hyperplasia, Cystic 9 (45%) 45 (90%) 10 (50%) 49 (98%) 1 (50%)
Endothelium, Hyperplasia, Cystic 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (20) (50) (20) (50) (2)
Myelofibrosis 33 (66%) 33 (66%)
Lymph Node (13) (49) (10) (50) (2)
Iliac, Hyperplasia 1 (2%) 2 (4%)
Lymph Node, Bronchial (7) (25) (7) (32)
Hyperplasia 1 (3%)
Lymph Node, Mandibular (1) (42) (40) (1)
Hyperplasia 1 (100%) 1 (2%) 3 (8%)
Lymph Node, Mediastinal (7) (18) (7) (17)
Hyperplasia 1 (6%) 1 (6%)
Lymph Node, Mesenteric (44) (47) (1)
Edema 1 (2%) 1 (2%)
Hyperplasia 3 (6%)
Spleen (20) (50) (20) (50) (2)
Atrophy 1 (2%)
Congestion 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 6 (12%) 10 (20%) 1 (50%)
Necrosis 1 (2%)
Thymus (20) (45) (19) (40) (1)
Atrophy 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (17) (38) (17) (35) (2)
Hyperplasia, Cystic 1 (3%) 4 (11%)
Skin (20) (50) (20) (50) (2)
Alopecia 5 (10%) 2 (4%)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (2%)
Inflammation, Chronic 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (20) (50) (20) (50) (2)
Sternum, Dysplasia 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (50) (20) (50) (2)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 1 (2%)
Vacuolization Cytoplasmic 7 (35%) 6 (30%)
Thalamus, Mineralization 28 (56%) 30 (60%)
Ventricle, Dilatation 1 (2%)
Peripheral Nerve (20) (49) (20) (50) (2)
Degeneration 1 (2%)
Vacuolization Cytoplasmic 1 (5%) 6 (30%)
Spinal Cord (20) (49) (20) (50) (2)
Ectopic Tissue 1 (5%)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 1 (2%)
Vacuolization Cytoplasmic 4 (20%) 7 (35%)
Meninges, Infiltration Cellular, Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (18) (49) (20) (47) (2)
Inflammation, Acute 1 (5%)
Lung (20) (50) (20) (50) (2)
Hemorrhage 1 (5%) 1 (5%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Nose (20) (50) (20) (50) (2)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Atypia Cellular 3 (15%) 3 (15%)
Respiratory Epithelium, Atypia Cellular 7 (35%) 7 (35%)
Trachea (20) (49) (20) (49) (2)
Inflammation, Chronic 2 (10%) 2 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (50) (20) (50) (2)
Hydronephrosis 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 32 (64%) 3 (15%) 36 (72%)
Inflammation, Chronic 2 (10%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 2 (4%)
Polyarteritis 1 (2%)
Cortex, Infiltration Cellular, Lymphocyte 2 (10%)
Interstitium, Infiltration Cellular 1 (5%)
Interstitium, Infiltration Cellular,
Lymphocyte 10 (50%) 6 (30%)
Renal Tubule, Bacterium 1 (2%)
Renal Tubule, Casts Protein 2 (10%) 2 (10%) 9 (18%)
Renal Tubule, Mineralization 2 (4%) 1 (2%)
Urinary Bladder (20) (50) (19) (50) (2)
Infiltration Cellular, Lymphocyte 2 (10%) 22 (44%) 3 (16%) 22 (44%)
Polyarteritis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 50 16 10 60 16
Scheduled Sacrifice 20 8 8 8
Early Deaths
Moribund Sacrifice 3 4
Dead 1 1 4
Moribund 1 1 2 12 2
Survivors
Terminal Sacrifice 45 6 40 6
Animals Examined Microscopically 20 50 2 10 60 2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (17) (49) (1) (10) (58) (2)
Infiltration Cellular, Lymphocyte 1 (6%) 4 (8%) 2 (3%)
Intestine Large, Cecum (20) (50) (2) (10) (58) (2)
Hyperplasia, Lymphoid 3 (15%)
Liver (20) (50) (2) (10) (60) (2)
Basophilic Focus 1 (2%) 1 (10%)
Clear Cell Focus 1 (2%) 5 (8%)
Cyst 1 (2%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 8 (40%)
Infiltration Cellular, Lymphocyte 1 (5%) 7 (14%) 1 (10%) 10 (17%)
Inflammation 6 (12%) 1 (2%)
Inflammation, Acute 1 (5%)
Mineralization 1 (2%)
Mixed Cell Focus 2 (4%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Necrosis, Focal 1 (5%)
Hepatocyte, Vacuolization Cytoplasmic 1 (5%) 2 (4%) 3 (5%)
Mesentery (3) (1)
Cyst 1 (33%)
Fat, Necrosis 2 (67%) 1 (100%)
Pancreas (20) (50) (2) (10) (60) (2)
Infiltration Cellular, Lymphocyte 3 (15%) 17 (34%) 16 (27%)
Acinus, Atrophy 4 (8%) 2 (3%)
Acinus, Inflammation, Chronic Active 1 (2%)
Duct, Dilatation 1 (2%)
Fat, Necrosis 1 (2%)
Salivary Glands (20) (50) (2) (10) (60) (2)
Atrophy 1 (2%)
Infiltration Cellular, Lymphocyte 11 (55%) 21 (42%) 1 (10%) 30 (50%)
Stomach, Forestomach (20) (49) (2) (10) (60) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Epithelium, Hyperplasia, Focal 1 (2%)
Stomach, Glandular (20) (49) (2) (10) (60) (2)
Infiltration Cellular, Lymphocyte 1 (2%)
Tooth (2) (2)
Dysplasia 2 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (50) (2) (10) (59) (2)
Cardiomyopathy 1 (10%)
Cardiomyopathy, Chronic 2 (4%) 34 (58%)
Degeneration 3 (30%) 7 (12%) 2 (100%)
Inflammation, Chronic Active 2 (3%)
Mineralization 1 (2%) 1 (2%)
Polyarteritis 1 (2%)
Valve, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (20) (50) (2) (10) (59) (2)
Spindle Cell, Hyperplasia 19 (95%) 50 (100%) 2 (100%) 10 (100%) 56 (95%) 2 (100%)
Adrenal Gland, Cortex (20) (50) (2) (10) (59) (2)
Amyloid Deposition 4 (8%) 4 (7%)
Cyst 1 (2%)
Hyperplasia 3 (6%) 3 (5%)
Hypertrophy 1 (2%)
Pigmentation 4 (8%) 3 (5%)
Vacuolization Cytoplasmic 2 (4%)
Adrenal Gland, Medulla (20) (50) (2) (10) (59) (2)
Hyperplasia 3 (6%) 1 (2%)
Islets, Pancreatic (20) (50) (2) (10) (60) (2)
Hyperplasia 1 (2%) 2 (3%)
Pituitary Gland (19) (48) (1) (10) (55) (2)
Angiectasis 8 (17%)
Hyperplasia 1 (2%)
Pars Distalis, Cyst 2 (4%)
Pars Distalis, Hyperplasia 1 (2%) 2 (4%)
Thyroid Gland (20) (50) (1) (9) (60) (2)
Inflammation, Chronic 1 (5%)
Polyarteritis 1 (2%)
Follicular Cell, Hyperplasia 6 (12%) 6 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (20) (50) (2) (10) (58) (2)
Cyst 1 (5%) 10 (20%) 1 (10%) 13 (22%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 1 (2%)
Mineralization 1 (2%)
Germinal Epithelium, Hyperplasia 1 (5%)
Uterus (20) (50) (2) (10) (60) (2)
Adenomyosis 1 (2%)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 10 (50%) 49 (98%) 2 (100%) 8 (80%) 51 (85%)
Endothelium, Hyperplasia, Cystic 1 (2%)
Vagina (1) (1)
Inflammation, Suppurative 1 (100%)
Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (20) (50) (2) (10) (60) (2)
Myelofibrosis 35 (70%) 1 (50%) 43 (72%)
Lymph Node (11) (50) (2) (7) (57) (2)
Pancreatic, Hyperplasia 1 (2%)
Lymph Node, Bronchial (7) (31) (1) (4) (30) (1)
Hyperplasia 3 (10%) 2 (7%)
Lymph Node, Mandibular (43) (46) (1)
Hyperplasia 1 (2%)
Lymph Node, Mediastinal (5) (14) (5) (13)
Hyperplasia 1 (7%)
Lymph Node, Mesenteric (48) (2) (1) (55) (1)
Angiectasis 1 (2%) 1 (2%)
Hyperplasia 2 (4%) 1 (2%)
Spleen (20) (50) (2) (10) (60) (2)
Atrophy 1 (2%) 1 (10%) 4 (7%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (5%) 4 (8%) 3 (5%)
Thymus (20) (43) (1) (9) (51) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Atrophy 1 (11%) 4 (8%) 1 (100%)
Hyperplasia 1 (2%) 1 (2%)
Necrosis 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (18) (38) (1) (10) (51) (2)
Cyst 1 (6%)
Hyperplasia, Cystic 2 (5%) 1 (2%)
Skin (20) (50) (2) (10) (60) (2)
Alopecia 3 (6%) 5 (8%)
Cyst 3 (5%)
Infiltration Cellular, Lymphocyte 2 (3%)
Inflammation, Chronic 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (20) (50) (2) (10) (60) (2)
Sternum, Dysplasia 1 (5%) 2 (4%) 1 (10%) 9 (15%)
Turbinate, Hyperostosis 1 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (50) (2) (10) (60) (2)
Gliosis 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (2%)
Inflammation 3 (5%)
Vacuolization Cytoplasmic 9 (45%)
Cerebellum, Degeneration 4 (40%) 11 (18%) 2 (100%)
Cerebrum, Degeneration 1 (10%) 2 (3%)
Thalamus, Mineralization 25 (50%) 15 (25%)
Ventricle, Dilatation 1 (2%) 3 (5%)
Ventricle, Mineralization 1 (2%)
Peripheral Nerve (20) (50) (2) (10) (59) (2)
Vacuolization Cytoplasmic 7 (35%)
Spinal Cord (20) (50) (2) (10) (59) (2)
Vacuolization Cytoplasmic 9 (45%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (19) (50) (1) (9) (58) (2)
Inflammation, Chronic 1 (5%)
Lung (20) (50) (2) (10) (60) (2)
Adenomatosis 1 (2%) 1 (50%)
Hyperplasia, Lymphoid 2 (4%)
Infiltration Cellular, Histiocyte 1 (5%) 1 (2%) 2 (3%)
Mineralization 1 (2%)
Interstitium, Inflammation, Acute, Multifocal 1 (2%)
Pleura, Inflammation, Chronic Active 1 (2%)
Nose (20) (50) (2) (10) (60) (2)
Exudate 2 (4%) 3 (5%)
Inflammation, Acute 2 (4%) 1 (2%)
Inflammation, Chronic 1 (5%)
Inflammation, Suppurative 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%)
Olfactory Epithelium, Atypia Cellular 4 (20%)
Olfactory Epithelium, Metaplasia 5 (8%)
Olfactory Epithelium, Necrosis 1 (2%)
Respiratory Epithelium, Atypia Cellular 6 (30%)
Trachea (19) (50) (2) (9) (60) (2)
Inflammation, Chronic 4 (21%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (50) (2) (10) (60) (2)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 32 (64%) 2 (100%) 34 (57%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Cortex, Cyst 3 (5%)
Cortex, Infiltration Cellular, Lymphocyte 1 (5%)
Interstitium, Infiltration Cellular,
Lymphocyte 9 (45%)
Renal Tubule, Casts Protein 1 (5%) 5 (10%) 1 (50%) 3 (5%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 1 (10%)
Urinary Bladder (20) (50) (1) (10) (59) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 4 (20%) 25 (50%) 1 (10%) 22 (37%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 50 16 20 49 16
Scheduled Sacrifice 20 10 19 8
Early Deaths
Dead 5 1 8
Moribund Sacrifice 2 4
Accident 1
Survivors
Terminal Sacrifice 40 6 37 8
Dead 1
Moribund Sacrifice 1
Animals Examined Microscopically 20 50 20 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (20) (44) (19) (43)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 2 (10%) 1 (2%) 1 (5%)
Inflammation, Acute 1 (5%) 2 (11%)
Intestine Large, Cecum (20) (48) (19) (47)
Hyperplasia, Lymphoid 1 (5%) 3 (16%)
Intestine Large, Colon (19) (49) (19) (49)
Diverticulum 1 (2%)
Intestine Small, Ileum (20) (46) (19) (46)
Hyperplasia, Lymphoid 1 (5%)
Liver (20) (50) (20) (49)
Basophilic Focus 2 (10%) 2 (4%) 2 (10%) 1 (2%)
Clear Cell Focus 4 (8%) 5 (10%)
Congestion 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 5 (10%) 2 (4%)
Hematopoietic Cell Proliferation 6 (30%) 5 (25%)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (2%)
Inflammation 1 (5%) 10 (20%) 1 (5%) 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 7 (14%) 1 (5%) 5 (10%)
Necrosis 1 (2%) 2 (4%)
Bile Duct, Proliferation 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 4 (20%) 7 (14%) 4 (20%) 8 (16%)
Mesentery (1) (2)
Fat, Necrosis 1 (100%) 2 (100%)
Pancreas (20) (50) (20) (49)
Basophilic Focus 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 7 (14%) 3 (6%)
Inflammation, Chronic 1 (2%)
Polyarteritis 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%)
Acinus, Cyst 1 (2%)
Acinus, Hyperplasia 1 (5%) 1 (2%)
Fat, Necrosis 1 (2%)
Salivary Glands (20) (50) (20) (49)
Infiltration Cellular, Lymphocyte 4 (20%) 25 (50%) 2 (10%) 23 (47%)
Stomach, Forestomach (20) (50) (19) (49)
Infiltration Cellular, Lymphocyte 1 (2%)
Stomach, Glandular (20) (50) (19) (49)
Atrophy 2 (4%)
Hyperplasia 3 (6%) 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%)
Inflammation, Chronic 3 (6%) 1 (2%)
Metaplasia 2 (4%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Tooth (2)
Dysplasia 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (50) (20) (49)
Cardiomyopathy, Chronic 4 (8%) 7 (14%)
Infiltration Cellular, Mononuclear Cell 1 (5%) 3 (15%)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%)
Necrosis, Acute 1 (2%)
Polyarteritis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (20) (49) (20) (47)
Spindle Cell, Hyperplasia 12 (60%) 41 (84%) 7 (35%) 31 (66%)
Adrenal Gland, Cortex (20) (49) (20) (47)
Cyst 1 (2%)
Hyperplasia 2 (10%) 10 (20%) 1 (5%) 2 (4%)
Hypertrophy 1 (5%) 12 (24%) 3 (6%)
Pigmentation 2 (4%) 2 (4%)
Vacuolization Cytoplasmic 15 (31%) 11 (23%)
Adrenal Gland, Medulla (20) (49) (20) (47)
Hyperplasia 1 (2%) 4 (9%)
Islets, Pancreatic (20) (50) (20) (49)
Hyperplasia 8 (16%) 10 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Parathyroid Gland (19) (39) (19) (46)
Cyst 1 (2%)
Pituitary Gland (18) (43) (15) (44)
Cyst 3 (7%) 1 (2%)
Thyroid Gland (20) (49) (20) (48)
Cyst 2 (4%) 1 (2%)
Inflammation, Chronic 1 (5%)
Follicular Cell, Hyperplasia 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (20) (50) (20) (49)
Infiltration Cellular, Lymphocyte 2 (4%)
Inflammation 1 (2%) 1 (5%)
Inflammation, Chronic 5 (25%) 3 (15%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Preputial Gland (1) (6) (4)
Cyst 1 (100%) 6 (100%) 4 (100%)
Infiltration Cellular, Lymphocyte 1 (17%)
Inflammation, Chronic Active 2 (33%)
Prostate (18) (45) (14) (49)
Infiltration Cellular, Lymphocyte 2 (4%) 5 (10%)
Inflammation, Chronic Active 2 (4%) 1 (7%)
Testes (20) (50) (20) (49)
Atrophy 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Polyarteritis 1 (2%)
Seminiferous Tubule, Degeneration 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (20) (50) (20) (49)
Myelofibrosis 1 (2%)
Lymph Node (5) (50) (9) (48)
Lumbar, Hyperplasia 1 (2%)
Lymph Node, Bronchial (3) (27) (4) (14)
Hyperplasia 2 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (43) (41)
Hyperplasia 1 (2%)
Lymph Node, Mediastinal (3) (22) (5) (9)
Hyperplasia 2 (9%)
Lymph Node, Mesenteric (44) (1) (46)
Hyperplasia 1 (2%)
Spleen (20) (50) (20) (49)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 12 (24%)
Hyperplasia, Lymphoid 3 (6%) 3 (6%)
Thymus (18) (41) (19) (36)
Atrophy 1 (2%) 1 (3%)
Cyst 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (20) (49) (20) (49)
Abscess 1 (2%)
Alopecia 2 (4%)
Cyst 1 (2%) 4 (8%)
Infiltration Cellular, Lymphocyte 2 (4%)
Inflammation, Chronic Active 2 (4%)
Prepuce, Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (50) (20) (49)
Infiltration Cellular, Lymphocyte 1 (2%)
Vacuolization Cytoplasmic 6 (30%)
Thalamus, Mineralization 28 (56%) 25 (51%)
Ventricle, Dilatation 1 (2%)
Peripheral Nerve (20) (47) (19) (49)
Vacuolization Cytoplasmic 3 (16%)
Sciatic, Infiltration Cellular, Lymphocyte 1 (2%)
Spinal Cord (20) (49) (20) (49)
Vacuolization Cytoplasmic 1 (5%) 7 (35%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (19) (49) (20) (48)
Inflammation, Chronic 2 (10%)
Inflammation, Suppurative 2 (4%)
Lung (20) (50) (20) (48)
Adenomatosis 1 (2%) 1 (2%)
Hemorrhage 2 (10%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (5%) 2 (4%) 6 (13%)
Inflammation, Chronic 1 (2%)
Nose (20) (50) (20) (49)
Inflammation, Acute 1 (5%) 1 (2%) 2 (4%)
Inflammation, Chronic 2 (10%)
Inflammation, Suppurative 1 (2%)
Trachea (20) (49) (20) (48)
Inflammation, Chronic 1 (5%) 3 (15%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (50) (20) (49)
Infarct 3 (6%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (5%) 19 (38%) 16 (33%)
Inflammation, Chronic 20 (40%) 2 (10%) 6 (12%)
Cortex, Cyst 7 (14%) 1 (2%)
Cortex, Infiltration Cellular, Lymphocyte 2 (10%) 1 (5%)
Cortex, Regeneration 1 (5%)
Interstitium, Infiltration Cellular,
Lymphocyte 9 (45%) 10 (50%)
Medulla, Mineralization 1 (5%) 1 (5%)
Renal Tubule, Casts Protein 3 (6%) 1 (5%) 6 (12%)
Renal Tubule, Degeneration 1 (5%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Mineralization 2 (10%) 38 (76%) 1 (5%) 30 (61%)
Renal Tubule, Regeneration 4 (20%)
Renal Tubule, Vacuolization Cytoplasmic 4 (8%) 2 (4%)
Urethra (1)
Foreign Body 1 (100%)
Urinary Bladder (20) (49) (20) (49)
Infiltration Cellular, Lymphocyte 6 (30%) 7 (14%) 7 (35%) 3 (6%)
Inflammation, Chronic 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL CONTROL 10 PPM 10 PPM 10 PPM
INTERIM TERMINAL NEURO INTERIM TERMINAL NEURO
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Polyarteritis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO TERMINAL NEURO
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 20 50 16 70 16
Scheduled Sacrifice 19 8 4
Early Deaths
Dead 1 3 1 14 4
Moribund Sacrifice 5 2
Moribund 1 1 37 8
Accident 1
Survivors
Terminal Sacrifice 40 6 16
Moribund 1
Animals Examined Microscopically 20 50 2 70 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (12) (45) (2) (54) (11)
Infiltration Cellular, Lymphocyte 1 (8%) 1 (2%)
Intestine Large, Cecum (19) (50) (2) (61) (11)
Hyperplasia, Glandular 1 (5%)
Hyperplasia, Lymphoid 1 (5%)
Liver (20) (50) (2) (70) (12)
Basophilic Focus 1 (2%) 1 (50%) 2 (3%)
Clear Cell Focus 8 (16%)
Hematopoietic Cell Proliferation 3 (15%) 1 (1%)
Infiltration Cellular, Lymphocyte 1 (2%) 2 (3%)
Inflammation 3 (6%) 2 (3%)
Mineralization 1 (1%)
Mixed Cell Focus 1 (2%)
Necrosis 1 (5%) 3 (6%) 2 (100%) 4 (6%) 1 (8%)
Hepatocyte, Vacuolization Cytoplasmic 5 (25%) 7 (14%) 18 (26%) 5 (42%)
Kupffer Cell, Hyperplasia 1 (1%)
Mesentery (1) (2)
Fat, Necrosis 1 (100%) 1 (50%)
Pancreas (20) (50) (2) (70) (12)
Infiltration Cellular, Lymphocyte 8 (16%) 2 (3%)
Acinus, Atrophy 2 (4%) 3 (4%)
Acinus, Degeneration 1 (1%) 1 (8%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (20) (50) (2) (68) (12)
Infiltration Cellular, Lymphocyte 4 (20%) 24 (48%) 1 (50%) 6 (9%)
Stomach, Glandular (20) (50) (2) (68) (12)
Atrophy 1 (2%)
Hyperplasia 3 (6%)
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO TERMINAL NEURO
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (2%) 2 (3%)
Metaplasia 1 (1%)
Mineralization 1 (2%) 1 (1%)
Necrosis 1 (1%) 1 (8%)
Tooth (4)
Dysplasia 4 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (20) (50) (2) (70) (12)
Cardiomyopathy, Chronic 10 (20%) 1 (50%) 24 (34%) 1 (8%)
Degeneration 32 (46%) 10 (83%)
Embolus Bacterial 1 (2%)
Infiltration Cellular, Mononuclear Cell 3 (15%)
Inflammation, Acute 1 (2%) 2 (3%)
Mineralization 1 (5%) 2 (3%)
Polyarteritis 1 (2%)
Atrium, Thrombosis 1 (2%) 1 (50%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (20) (50) (2) (68) (12)
Spindle Cell, Hyperplasia 7 (35%) 38 (76%) 1 (50%) 33 (49%) 6 (50%)
Adrenal Gland, Cortex (20) (50) (2) (68) (12)
Angiectasis 1 (2%)
Hyperplasia 1 (5%) 3 (6%) 2 (3%)
Hypertrophy 1 (5%) 5 (10%) 3 (4%)
Necrosis 1 (2%)
Pigmentation 3 (6%)
Vacuolization Cytoplasmic 12 (24%) 4 (6%)
Adrenal Gland, Medulla (20) (50) (2) (68) (12)
Hyperplasia 1 (1%)
Islets, Pancreatic (20) (50) (2) (70) (12)
Hyperplasia 17 (34%) 1 (1%)
Parathyroid Gland (18) (48) (1) (45) (7)
Cyst 2 (4%) 1 (2%)
Pituitary Gland (16) (46) (2) (51) (8)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (20) (50) (1) (65) (12)
Cyst 1 (5%) 1 (2%)
Inflammation, Chronic 1 (5%)
Follicular Cell, Hyperplasia 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO TERMINAL NEURO
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (20) (50) (2) (69) (12)
Degeneration 1 (1%)
Inflammation, Chronic 3 (15%)
Inflammation, Chronic Active 1 (2%)
Polyarteritis 1 (2%)
Preputial Gland (1) (9) (2)
Cyst 1 (100%) 8 (89%) 2 (100%)
Inflammation, Chronic Active 2 (22%)
Prostate (17) (45) (2) (66) (12)
Infiltration Cellular, Lymphocyte 1 (2%)
Testes (20) (50) (2) (70) (12)
Degeneration 1 (5%) 1 (2%) 28 (40%) 10 (83%)
Mineralization 2 (4%) 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (20) (50) (2) (65) (10)
Hyperplasia, Re Cell 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node, Bronchial (5) (21) (1) (18) (3)
Hyperplasia 1 (5%)
Lymph Node, Mandibular (1) (43) (1) (27) (2)
Hyperplasia 2 (5%)
Pigmentation 1 (4%)
Lymph Node, Mesenteric (41) (1) (46) (7)
Angiectasis 1 (2%)
Edema 1 (2%)
Spleen (20) (50) (2) (70) (11)
Atrophy 1 (5%) 10 (14%) 3 (27%)
Degeneration 1 (1%)
Hematopoietic Cell Proliferation 9 (18%) 1 (50%) 1 (1%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Re Cell 1 (2%)
Thymus (18) (41) (1) (42) (6)
Atrophy 1 (2%) 11 (26%) 4 (67%)
Necrosis 9 (21%) 2 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO TERMINAL NEURO
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (20) (50) (2) (70) (12)
Abscess 1 (2%)
Alopecia 1 (2%) 1 (1%)
Cyst 3 (6%)
Infiltration Cellular, Lymphocyte 1 (1%)
Inflammation, Chronic Active 1 (2%) 2 (3%)
Prepuce, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (20) (50) (2) (69) (12)
Sternum, Dysplasia 1 (5%) 3 (6%) 14 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (50) (2) (70) (12)
Polyarteritis 1 (2%) 1 (50%)
Vacuolization Cytoplasmic 3 (15%)
Cerebellum, Degeneration 31 (44%) 9 (75%)
Cerebrum, Degeneration 11 (16%) 6 (50%)
Thalamus, Mineralization 25 (50%) 1 (50%) 15 (21%)
Spinal Cord (20) (49) (2) (70) (11)
Vacuolization Cytoplasmic 4 (20%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (20) (50) (1) (58) (11)
Inflammation, Acute 1 (5%)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 1 (9%)
Lung (20) (50) (2) (70) (12)
Adenomatosis 2 (4%) 1 (1%)
Hemorrhage 1 (2%) 2 (3%)
Infiltration Cellular, Histiocyte 3 (6%)
Inflammation, Chronic 1 (8%)
Pigmentation 1 (2%) 1 (1%)
Mediastinum, Inflammation, Acute 1 (1%)
Nose (20) (50) (2) (69) (12)
Inflammation, Acute 5 (10%) 8 (12%) 1 (8%)
Inflammation, Chronic 2 (10%)
Inflammation, Suppurative 1 (2%) 2 (3%)
Olfactory Epithelium, Atrophy 1 (8%)
Olfactory Epithelium, Metaplasia 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05101-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL BROMIDE Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:35:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 33 PPM 33 PPM 33 PPM 100 PPM 100 PPM
INTERIM TERMINAL NEURO TERMINAL NEURO
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Necrosis 6 (9%) 4 (33%)
Respiratory Epithelium, Metaplasia 1 (1%) 1 (8%)
Respiratory Epithelium, Necrosis 1 (1%)
Trachea (20) (50) (1) (67) (12)
Inflammation, Chronic 3 (15%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (50) (2) (70) (12)
Infarct 1 (2%) 2 (3%)
Infiltration Cellular, Lymphocyte 18 (36%) 8 (11%)
Inflammation, Chronic 16 (32%) 3 (4%) 1 (8%)
Polyarteritis 1 (50%)
Cortex, Cyst 1 (5%) 5 (10%) 2 (3%)
Cortex, Infiltration Cellular, Lymphocyte 1 (5%)
Cortex, Regeneration 2 (10%)
Interstitium, Infiltration Cellular,
Lymphocyte 7 (35%)
Medulla, Mineralization 1 (5%)
Renal Tubule, Casts Protein 6 (12%) 5 (7%)
Renal Tubule, Mineralization 32 (64%) 6 (9%)
Renal Tubule, Pigmentation 1 (2%) 1 (1%)
Renal Tubule, Regeneration 3 (15%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (20) (47) (2) (68) (12)
Hyperplasia 1 (1%)
Infiltration Cellular, Lymphocyte 5 (25%) 4 (9%) 1 (1%)
Inflammation, Chronic 1 (1%)
Polyarteritis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
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