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https://ntp.niehs.nih.gov/go/1683

TDMS Study 05101-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           METHYL BROMIDE


NTP Experiment-Test: 05101-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48




       Facility:  Brookhaven National Laboratory

       Chemical CAS #:  74-83-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          21           50           15           20           50           16           
  Scheduled Sacrifice                                 19                         9           20                         7           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            4                                      5            1           
    Dead                                               1            6                                      3            1           
    Moribund                                                        3                                      1                        
  Survivors                                                                                                                         
    Moribund Sacrifice                                              1                                                               
    Terminal Sacrifice                                             36            6                        41            7           
  Animals Examined Microscopically                    20           50                        20           50            2           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (20)         (46)                      (20)         (49)         (2)          
      Diverticulum                                                                                         1 (2%)                   
      Infiltration Cellular, Lymphocyte                             2 (4%)                    3 (15%)      7 (14%)                  
   Intestine Small, Ileum                             (20)         (49)                      (20)         (50)         (2)          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (20)         (48)                      (20)         (49)         (2)          
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
   Liver                                              (20)         (50)                      (20)         (50)         (2)          
      Basophilic Focus                                              3 (6%)                                 1 (2%)                   
      Clear Cell Focus                                              3 (6%)                                 5 (10%)                  
      Eosinophilic Focus                                            1 (2%)                                 1 (2%)                   
      Hematopoietic Cell Proliferation                 9 (45%)                                7 (35%)                               
      Infiltration Cellular, Lymphocyte                1 (5%)      11 (22%)                               18 (36%)      1 (50%)     
      Inflammation                                                  7 (14%)                                1 (2%)                   
      Mixed Cell Focus                                              2 (4%)                                                          
      Necrosis, Focal                                  1 (5%)                                                                       
      Thrombosis                                                    1 (2%)                                                          
      Bile Duct, Hyperplasia                                                                               1 (2%)                   
      Hepatocyte, Vacuolization Cytoplasmic            1 (5%)                                 1 (5%)                                
   Mesentery                                                       (2)                                    (2)                       
      Cyst                                                          1 (50%)                                                         
      Fat, Necrosis                                                 1 (50%)                                2 (100%)                 
   Pancreas                                           (20)         (50)                      (20)         (50)         (2)          
      Degeneration                                     1 (5%)                                                                       
      Infiltration Cellular, Lymphocyte                4 (20%)     19 (38%)                   3 (15%)     24 (48%)                  
      Acinus, Atrophy                                               1 (2%)                                 2 (4%)                   
      Acinus, Cyst                                                                                         1 (2%)                   
      Acinus, Hyperplasia                                                                                               1 (50%)     
   Salivary Glands                                    (20)         (49)                      (20)         (49)         (2)          
      Infiltration Cellular, Lymphocyte                5 (25%)     35 (71%)                   8 (40%)     25 (51%)      2 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (20)         (50)                      (20)         (50)         (2)          
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (20)         (50)                      (20)         (50)         (2)          
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Mineralization                                                2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)                      (20)         (50)         (2)          
      Cardiomyopathy, Chronic                                       2 (4%)                                 4 (8%)                   
      Degeneration                                                  1 (2%)                                                          
      Embolus Bacterial                                                                                    1 (2%)                   
      Infiltration Cellular, Mononuclear Cell          1 (5%)                                                                       
      Inflammation, Acute                                                                                  1 (2%)                   
      Mineralization                                   1 (5%)                                              1 (2%)                   
      Polyarteritis                                                 2 (4%)                                 2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (19)         (50)                      (20)         (50)         (2)          
      Spindle Cell, Hyperplasia                       18 (95%)     47 (94%)                  19 (95%)     49 (98%)      2 (100%)    
   Adrenal Gland, Cortex                              (19)         (50)                      (20)         (50)         (2)          
      Amyloid Deposition                                            3 (6%)                                 5 (10%)                  
      Cyst                                                                                                 1 (2%)                   
      Hematopoietic Cell Proliferation                                                                     1 (2%)                   
      Hyperplasia                                                   3 (6%)                                 3 (6%)                   
      Hypertrophy                                                   2 (4%)                                 2 (4%)                   
      Pigmentation                                                  9 (18%)                                6 (12%)                  
      Vacuolization Cytoplasmic                                     4 (8%)                    1 (5%)       2 (4%)                   
      Spindle Cell, Hyperplasia                                                                            1 (2%)                   
   Adrenal Gland, Medulla                             (19)         (50)                      (20)         (50)         (2)          
      Hyperplasia                                                   4 (8%)                                 1 (2%)                   
   Islets, Pancreatic                                 (20)         (50)                      (20)         (50)         (2)          
      Hyperplasia                                                                                          2 (4%)                   
   Parathyroid Gland                                  (16)         (45)                      (19)         (47)         (2)          
      Cyst                                                          3 (7%)                                 1 (2%)                   
   Pituitary Gland                                    (18)         (49)                      (18)         (48)         (2)          
      Angiectasis                                                   2 (4%)                                 2 (4%)                   
      Pars Distalis, Cyst                                                                                  1 (2%)                   
      Pars Distalis, Hyperplasia                                    6 (12%)                                5 (10%)                  
   Thyroid Gland                                      (19)         (49)                      (20)         (49)         (2)          
      Infiltration Cellular, Lymphocyte                             2 (4%)                                 4 (8%)                   
      Polyarteritis                                                 1 (2%)                                                          
      Follicular Cell, Hyperplasia                                  7 (14%)                               10 (20%)                  
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (20)         (50)                      (20)         (49)         (2)          
      Cyst                                                          8 (16%)                   2 (10%)     10 (20%)                  
      Infiltration Cellular, Lymphocyte                                                                    2 (4%)                   
      Pigmentation                                                  2 (4%)                                                          
   Uterus                                             (20)         (50)                      (20)         (50)         (2)          
      Angiectasis                                                                                          2 (4%)                   
      Hemorrhage                                                                                           1 (2%)                   
      Infiltration Cellular, Lymphocyte                                                                    1 (2%)                   
      Endometrium, Hyperplasia, Cystic                 9 (45%)     45 (90%)                  10 (50%)     49 (98%)      1 (50%)     
      Endothelium, Hyperplasia, Cystic                 1 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (20)         (50)                      (20)         (50)         (2)          
      Myelofibrosis                                                33 (66%)                               33 (66%)                  
   Lymph Node                                         (13)         (49)                      (10)         (50)         (2)          
      Iliac, Hyperplasia                                            1 (2%)                                 2 (4%)                   
   Lymph Node, Bronchial                              (7)          (25)                      (7)          (32)                      
      Hyperplasia                                                                                          1 (3%)                   
   Lymph Node, Mandibular                             (1)          (42)                                   (40)         (1)          
      Hyperplasia                                      1 (100%)     1 (2%)                                 3 (8%)                   
   Lymph Node, Mediastinal                            (7)          (18)                      (7)          (17)                      
      Hyperplasia                                                   1 (6%)                                 1 (6%)                   
   Lymph Node, Mesenteric                                          (44)                                   (47)         (1)          
      Edema                                                         1 (2%)                                 1 (2%)                   
      Hyperplasia                                                                                          3 (6%)                   
   Spleen                                             (20)         (50)                      (20)         (50)         (2)          
      Atrophy                                                                                              1 (2%)                   
      Congestion                                                    1 (2%)                                                          
      Fibrosis                                                                                             1 (2%)                   
      Hematopoietic Cell Proliferation                              2 (4%)                                 3 (6%)                   
      Hyperplasia, Lymphoid                                         6 (12%)                               10 (20%)      1 (50%)     
      Necrosis                                                                                             1 (2%)                   
   Thymus                                             (20)         (45)                      (19)         (40)         (1)          
      Atrophy                                                       1 (2%)                                 1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (17)         (38)                      (17)         (35)         (2)          
      Hyperplasia, Cystic                                           1 (3%)                                 4 (11%)                  
   Skin                                               (20)         (50)                      (20)         (50)         (2)          
      Alopecia                                                      5 (10%)                                2 (4%)                   
      Infiltration Cellular, Lymphocyte                             2 (4%)                                 1 (2%)                   
      Inflammation, Chronic                            1 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (20)         (50)                      (20)         (50)         (2)          
      Sternum, Dysplasia                                                                                   2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (50)                      (20)         (50)         (2)          
      Hemorrhage                                                                                           1 (2%)                   
      Infiltration Cellular, Lymphocyte                                                                    1 (2%)                   
      Inflammation                                                                                         1 (2%)                   
      Vacuolization Cytoplasmic                        7 (35%)                                6 (30%)                               
      Thalamus, Mineralization                                     28 (56%)                               30 (60%)                  
      Ventricle, Dilatation                                                                                1 (2%)                   
   Peripheral Nerve                                   (20)         (49)                      (20)         (50)         (2)          
      Degeneration                                                                                         1 (2%)                   
      Vacuolization Cytoplasmic                        1 (5%)                                 6 (30%)                               
   Spinal Cord                                        (20)         (49)                      (20)         (50)         (2)          
      Ectopic Tissue                                   1 (5%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Vacuolization Cytoplasmic                        4 (20%)                                7 (35%)                               
      Meninges, Infiltration Cellular, Lymphocyte                                                          1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (18)         (49)                      (20)         (47)         (2)          
      Inflammation, Acute                                                                     1 (5%)                                
   Lung                                               (20)         (50)                      (20)         (50)         (2)          
      Hemorrhage                                       1 (5%)                                 1 (5%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                                 1 (2%)                   
      Infiltration Cellular, Histiocyte                                                                    1 (2%)                   
      Alveolar Epithelium, Hyperplasia                                                                     1 (2%)                   
   Nose                                               (20)         (50)                      (20)         (50)         (2)          
      Inflammation, Acute                                                                                  1 (2%)                   
      Inflammation, Chronic                                                                                2 (4%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Atypia Cellular            3 (15%)                                3 (15%)                               
      Respiratory Epithelium, Atypia Cellular          7 (35%)                                7 (35%)                               
   Trachea                                            (20)         (49)                      (20)         (49)         (2)          
      Inflammation, Chronic                            2 (10%)                                2 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)                      (20)         (50)         (2)          
      Hydronephrosis                                                                                       1 (2%)                   
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                            32 (64%)                   3 (15%)     36 (72%)                  
      Inflammation, Chronic                            2 (10%)      1 (2%)                                                          
      Inflammation, Suppurative                                                                            1 (2%)                   
      Metaplasia, Osseous                                           2 (4%)                                                          
      Polyarteritis                                                 1 (2%)                                                          
      Cortex, Infiltration Cellular, Lymphocyte                                               2 (10%)                               
      Interstitium, Infiltration Cellular                                                     1 (5%)                                
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                  10 (50%)                                6 (30%)                               
      Renal Tubule, Bacterium                                                                              1 (2%)                   
      Renal Tubule, Casts Protein                      2 (10%)                                2 (10%)      9 (18%)                  
      Renal Tubule, Mineralization                                  2 (4%)                                 1 (2%)                   
   Urinary Bladder                                    (20)         (50)                      (19)         (50)         (2)          
      Infiltration Cellular, Lymphocyte                2 (10%)     22 (44%)                   3 (16%)     22 (44%)                  
      Polyarteritis                                                 1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          20           50           16           10           60           16           
  Scheduled Sacrifice                                 20                         8            8                         8           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              3                                      4                        
    Dead                                                            1            1                         4                        
    Moribund                                                        1            1            2           12            2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                             45            6                        40            6           
  Animals Examined Microscopically                    20           50            2           10           60            2           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (17)         (49)         (1)          (10)         (58)         (2)          
      Infiltration Cellular, Lymphocyte                1 (6%)       4 (8%)                                 2 (3%)                   
   Intestine Large, Cecum                             (20)         (50)         (2)          (10)         (58)         (2)          
      Hyperplasia, Lymphoid                            3 (15%)                                                                      
   Liver                                              (20)         (50)         (2)          (10)         (60)         (2)          
      Basophilic Focus                                              1 (2%)                    1 (10%)                               
      Clear Cell Focus                                              1 (2%)                                 5 (8%)                   
      Cyst                                                          1 (2%)                                                          
      Eosinophilic Focus                                            1 (2%)                                                          
      Hematopoietic Cell Proliferation                 8 (40%)                                                                      
      Infiltration Cellular, Lymphocyte                1 (5%)       7 (14%)                   1 (10%)     10 (17%)                  
      Inflammation                                                  6 (12%)                                1 (2%)                   
      Inflammation, Acute                              1 (5%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Mixed Cell Focus                                              2 (4%)                                 1 (2%)                   
      Necrosis                                                      1 (2%)                                 1 (2%)                   
      Necrosis, Focal                                  1 (5%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            1 (5%)       2 (4%)                                 3 (5%)                   
   Mesentery                                                       (3)                                    (1)                       
      Cyst                                                          1 (33%)                                                         
      Fat, Necrosis                                                 2 (67%)                                1 (100%)                 
   Pancreas                                           (20)         (50)         (2)          (10)         (60)         (2)          
      Infiltration Cellular, Lymphocyte                3 (15%)     17 (34%)                               16 (27%)                  
      Acinus, Atrophy                                               4 (8%)                                 2 (3%)                   
      Acinus, Inflammation, Chronic Active                                                                 1 (2%)                   
      Duct, Dilatation                                              1 (2%)                                                          
      Fat, Necrosis                                                                                        1 (2%)                   
   Salivary Glands                                    (20)         (50)         (2)          (10)         (60)         (2)          
      Atrophy                                                                                              1 (2%)                   
      Infiltration Cellular, Lymphocyte               11 (55%)     21 (42%)                   1 (10%)     30 (50%)                  
   Stomach, Forestomach                               (20)         (49)         (2)          (10)         (60)         (2)          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Epithelium, Hyperplasia, Focal                                                                       1 (2%)                   
   Stomach, Glandular                                 (20)         (49)         (2)          (10)         (60)         (2)          
      Infiltration Cellular, Lymphocyte                                                                    1 (2%)                   
   Tooth                                                           (2)                                    (2)                       
      Dysplasia                                                     2 (100%)                               2 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)         (2)          (10)         (59)         (2)          
      Cardiomyopathy                                                                          1 (10%)                               
      Cardiomyopathy, Chronic                                       2 (4%)                                34 (58%)                  
      Degeneration                                                                            3 (30%)      7 (12%)      2 (100%)    
      Inflammation, Chronic Active                                                                         2 (3%)                   
      Mineralization                                                1 (2%)                                 1 (2%)                   
      Polyarteritis                                                                                        1 (2%)                   
      Valve, Cyst                                                                                          1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (20)         (50)         (2)          (10)         (59)         (2)          
      Spindle Cell, Hyperplasia                       19 (95%)     50 (100%)     2 (100%)    10 (100%)    56 (95%)      2 (100%)    
   Adrenal Gland, Cortex                              (20)         (50)         (2)          (10)         (59)         (2)          
      Amyloid Deposition                                            4 (8%)                                 4 (7%)                   
      Cyst                                                                                                 1 (2%)                   
      Hyperplasia                                                   3 (6%)                                 3 (5%)                   
      Hypertrophy                                                   1 (2%)                                                          
      Pigmentation                                                  4 (8%)                                 3 (5%)                   
      Vacuolization Cytoplasmic                                     2 (4%)                                                          
   Adrenal Gland, Medulla                             (20)         (50)         (2)          (10)         (59)         (2)          
      Hyperplasia                                                   3 (6%)                                 1 (2%)                   
   Islets, Pancreatic                                 (20)         (50)         (2)          (10)         (60)         (2)          
      Hyperplasia                                                   1 (2%)                                 2 (3%)                   
   Pituitary Gland                                    (19)         (48)         (1)          (10)         (55)         (2)          
      Angiectasis                                                   8 (17%)                                                         
      Hyperplasia                                                   1 (2%)                                                          
      Pars Distalis, Cyst                                           2 (4%)                                                          
      Pars Distalis, Hyperplasia                                    1 (2%)                                 2 (4%)                   
   Thyroid Gland                                      (20)         (50)         (1)          (9)          (60)         (2)          
      Inflammation, Chronic                            1 (5%)                                                                       
      Polyarteritis                                                                                        1 (2%)                   
      Follicular Cell, Hyperplasia                                  6 (12%)                                6 (10%)                  
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (20)         (50)         (2)          (10)         (58)         (2)          
      Cyst                                             1 (5%)      10 (20%)                   1 (10%)     13 (22%)                  
      Hemorrhage                                                    1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation                                                                                         1 (2%)                   
      Mineralization                                                1 (2%)                                                          
      Germinal Epithelium, Hyperplasia                 1 (5%)                                                                       
   Uterus                                             (20)         (50)         (2)          (10)         (60)         (2)          
      Adenomyosis                                                                                          1 (2%)                   
      Angiectasis                                                   1 (2%)                                                          
      Atrophy                                                                                              1 (2%)                   
      Thrombosis                                                                                           1 (2%)                   
      Endometrium, Hyperplasia, Cystic                10 (50%)     49 (98%)      2 (100%)     8 (80%)     51 (85%)                  
      Endothelium, Hyperplasia, Cystic                                                                     1 (2%)                   
   Vagina                                                                                    (1)          (1)                       
      Inflammation, Suppurative                                                                            1 (100%)                 
      Epithelium, Hyperplasia                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (20)         (50)         (2)          (10)         (60)         (2)          
      Myelofibrosis                                                35 (70%)      1 (50%)                  43 (72%)                  
   Lymph Node                                         (11)         (50)         (2)          (7)          (57)         (2)          
      Pancreatic, Hyperplasia                                                                              1 (2%)                   
   Lymph Node, Bronchial                              (7)          (31)         (1)          (4)          (30)         (1)          
      Hyperplasia                                                   3 (10%)                                2 (7%)                   
   Lymph Node, Mandibular                                          (43)                                   (46)         (1)          
      Hyperplasia                                                                                          1 (2%)                   
   Lymph Node, Mediastinal                            (5)          (14)                      (5)          (13)                      
      Hyperplasia                                                   1 (7%)                                                          
   Lymph Node, Mesenteric                                          (48)         (2)          (1)          (55)         (1)          
      Angiectasis                                                   1 (2%)                                 1 (2%)                   
      Hyperplasia                                                   2 (4%)                                 1 (2%)                   
   Spleen                                             (20)         (50)         (2)          (10)         (60)         (2)          
      Atrophy                                                       1 (2%)                    1 (10%)      4 (7%)                   
      Hematopoietic Cell Proliferation                              3 (6%)                                 1 (2%)                   
      Hemorrhage                                                                                           1 (2%)                   
      Hyperplasia, Lymphoid                            1 (5%)       4 (8%)                                 3 (5%)                   
   Thymus                                             (20)         (43)         (1)          (9)          (51)         (1)          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Atrophy                                                                                 1 (11%)      4 (8%)       1 (100%)    
      Hyperplasia                                                   1 (2%)                                 1 (2%)                   
      Necrosis                                                                                             2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (18)         (38)         (1)          (10)         (51)         (2)          
      Cyst                                             1 (6%)                                                                       
      Hyperplasia, Cystic                                           2 (5%)                                 1 (2%)                   
   Skin                                               (20)         (50)         (2)          (10)         (60)         (2)          
      Alopecia                                                      3 (6%)                                 5 (8%)                   
      Cyst                                                                                                 3 (5%)                   
      Infiltration Cellular, Lymphocyte                                                                    2 (3%)                   
      Inflammation, Chronic                            1 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (20)         (50)         (2)          (10)         (60)         (2)          
      Sternum, Dysplasia                               1 (5%)       2 (4%)                    1 (10%)      9 (15%)                  
      Turbinate, Hyperostosis                                                                 1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (50)         (2)          (10)         (60)         (2)          
      Gliosis                                                                                              1 (2%)                   
      Infiltration Cellular, Lymphocyte                             2 (4%)                                 1 (2%)                   
      Inflammation                                                                                         3 (5%)                   
      Vacuolization Cytoplasmic                        9 (45%)                                                                      
      Cerebellum, Degeneration                                                                4 (40%)     11 (18%)      2 (100%)    
      Cerebrum, Degeneration                                                                  1 (10%)      2 (3%)                   
      Thalamus, Mineralization                                     25 (50%)                               15 (25%)                  
      Ventricle, Dilatation                                         1 (2%)                                 3 (5%)                   
      Ventricle, Mineralization                                     1 (2%)                                                          
   Peripheral Nerve                                   (20)         (50)         (2)          (10)         (59)         (2)          
      Vacuolization Cytoplasmic                        7 (35%)                                                                      
   Spinal Cord                                        (20)         (50)         (2)          (10)         (59)         (2)          
      Vacuolization Cytoplasmic                        9 (45%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (19)         (50)         (1)          (9)          (58)         (2)          
      Inflammation, Chronic                            1 (5%)                                                                       
   Lung                                               (20)         (50)         (2)          (10)         (60)         (2)          
      Adenomatosis                                                  1 (2%)       1 (50%)                                            
      Hyperplasia, Lymphoid                                         2 (4%)                                                          
      Infiltration Cellular, Histiocyte                1 (5%)       1 (2%)                                 2 (3%)                   
      Mineralization                                                                                       1 (2%)                   
      Interstitium, Inflammation, Acute, Multifocal                                                        1 (2%)                   
      Pleura, Inflammation, Chronic Active                                                                 1 (2%)                   
   Nose                                               (20)         (50)         (2)          (10)         (60)         (2)          
      Exudate                                                       2 (4%)                                 3 (5%)                   
      Inflammation, Acute                                           2 (4%)                                 1 (2%)                   
      Inflammation, Chronic                            1 (5%)                                                                       
      Inflammation, Suppurative                                                                            1 (2%)                   
      Nasolacrimal Duct, Inflammation                                                                      1 (2%)                   
      Olfactory Epithelium, Atypia Cellular            4 (20%)                                                                      
      Olfactory Epithelium, Metaplasia                                                                     5 (8%)                   
      Olfactory Epithelium, Necrosis                                                                       1 (2%)                   
      Respiratory Epithelium, Atypia Cellular          6 (30%)                                                                      
   Trachea                                            (19)         (50)         (2)          (9)          (60)         (2)          
      Inflammation, Chronic                            4 (21%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)         (2)          (10)         (60)         (2)          
      Infarct                                                                                              1 (2%)                   
      Infiltration Cellular, Lymphocyte                            32 (64%)      2 (100%)                 34 (57%)                  
      Metaplasia, Osseous                                           1 (2%)                                 1 (2%)                   
      Cortex, Cyst                                                                                         3 (5%)                   
      Cortex, Infiltration Cellular, Lymphocyte        1 (5%)                                                                       
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                   9 (45%)                                                                      
      Renal Tubule, Casts Protein                      1 (5%)       5 (10%)      1 (50%)                   3 (5%)                   
      Renal Tubule, Pigmentation                                    1 (2%)                                                          
      Renal Tubule, Regeneration                                                              1 (10%)                               
   Urinary Bladder                                    (20)         (50)         (1)          (10)         (59)         (2)          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Infiltration Cellular, Lymphocyte                4 (20%)     25 (50%)                   1 (10%)     22 (37%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          20           50           16           20           49           16           
  Scheduled Sacrifice                                 20                        10           19                         8           
  Early Deaths                                                                                                                      
    Dead                                                            5                         1            8                        
    Moribund Sacrifice                                              2                                      4                        
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                             40            6                        37            8           
    Dead                                                            1                                                               
    Moribund Sacrifice                                              1                                                               
  Animals Examined Microscopically                    20           50                        20           49                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (20)         (44)                      (19)         (43)                      
      Hyperplasia                                                                                          1 (2%)                   
      Hyperplasia, Focal                                            1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                2 (10%)      1 (2%)                    1 (5%)                                
      Inflammation, Acute                              1 (5%)                                 2 (11%)                               
   Intestine Large, Cecum                             (20)         (48)                      (19)         (47)                      
      Hyperplasia, Lymphoid                            1 (5%)                                 3 (16%)                               
   Intestine Large, Colon                             (19)         (49)                      (19)         (49)                      
      Diverticulum                                                  1 (2%)                                                          
   Intestine Small, Ileum                             (20)         (46)                      (19)         (46)                      
      Hyperplasia, Lymphoid                            1 (5%)                                                                       
   Liver                                              (20)         (50)                      (20)         (49)                      
      Basophilic Focus                                 2 (10%)      2 (4%)                    2 (10%)      1 (2%)                   
      Clear Cell Focus                                              4 (8%)                                 5 (10%)                  
      Congestion                                                                                           1 (2%)                   
      Cyst                                                          1 (2%)                                                          
      Eosinophilic Focus                                            5 (10%)                                2 (4%)                   
      Hematopoietic Cell Proliferation                 6 (30%)                                5 (25%)                               
      Infiltration Cellular, Lymphocyte                             2 (4%)                                 1 (2%)                   
      Inflammation                                     1 (5%)      10 (20%)                   1 (5%)       1 (2%)                   
      Mineralization                                                                                       1 (2%)                   
      Mixed Cell Focus                                              7 (14%)                   1 (5%)       5 (10%)                  
      Necrosis                                                      1 (2%)                                 2 (4%)                   
      Bile Duct, Proliferation                                      1 (2%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic            4 (20%)      7 (14%)                   4 (20%)      8 (16%)                  
   Mesentery                                                                                 (1)          (2)                       
      Fat, Necrosis                                                                           1 (100%)     2 (100%)                 
   Pancreas                                           (20)         (50)                      (20)         (49)                      
      Basophilic Focus                                              1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Lymphocyte                             7 (14%)                                3 (6%)                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Polyarteritis                                                 1 (2%)                                                          
      Acinus, Atrophy                                               1 (2%)                                 1 (2%)                   
      Acinus, Cyst                                                                                         1 (2%)                   
      Acinus, Hyperplasia                                                                     1 (5%)       1 (2%)                   
      Fat, Necrosis                                                                                        1 (2%)                   
   Salivary Glands                                    (20)         (50)                      (20)         (49)                      
      Infiltration Cellular, Lymphocyte                4 (20%)     25 (50%)                   2 (10%)     23 (47%)                  
   Stomach, Forestomach                               (20)         (50)                      (19)         (49)                      
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
   Stomach, Glandular                                 (20)         (50)                      (19)         (49)                      
      Atrophy                                                                                              2 (4%)                   
      Hyperplasia                                                   3 (6%)                                 1 (2%)                   
      Infiltration Cellular, Lymphocyte                             2 (4%)                                                          
      Inflammation, Chronic                                         3 (6%)                                 1 (2%)                   
      Metaplasia                                                    2 (4%)                                 1 (2%)                   
      Mineralization                                                1 (2%)                                 1 (2%)                   
   Tooth                                                           (2)                                                              
      Dysplasia                                                     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)                      (20)         (49)                      
      Cardiomyopathy, Chronic                                       4 (8%)                                 7 (14%)                  
      Infiltration Cellular, Mononuclear Cell          1 (5%)                                 3 (15%)                               
      Inflammation, Chronic Active                                                                         2 (4%)                   
      Mineralization                                                1 (2%)                                                          
      Necrosis, Acute                                                                                      1 (2%)                   
      Polyarteritis                                                                                        1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (20)         (49)                      (20)         (47)                      
      Spindle Cell, Hyperplasia                       12 (60%)     41 (84%)                   7 (35%)     31 (66%)                  
   Adrenal Gland, Cortex                              (20)         (49)                      (20)         (47)                      
      Cyst                                                          1 (2%)                                                          
      Hyperplasia                                      2 (10%)     10 (20%)                   1 (5%)       2 (4%)                   
      Hypertrophy                                      1 (5%)      12 (24%)                                3 (6%)                   
      Pigmentation                                                  2 (4%)                                 2 (4%)                   
      Vacuolization Cytoplasmic                                    15 (31%)                               11 (23%)                  
   Adrenal Gland, Medulla                             (20)         (49)                      (20)         (47)                      
      Hyperplasia                                                   1 (2%)                                 4 (9%)                   
   Islets, Pancreatic                                 (20)         (50)                      (20)         (49)                      
      Hyperplasia                                                   8 (16%)                               10 (20%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Parathyroid Gland                                  (19)         (39)                      (19)         (46)                      
      Cyst                                                                                                 1 (2%)                   
   Pituitary Gland                                    (18)         (43)                      (15)         (44)                      
      Cyst                                                          3 (7%)                                 1 (2%)                   
   Thyroid Gland                                      (20)         (49)                      (20)         (48)                      
      Cyst                                                          2 (4%)                                 1 (2%)                   
      Inflammation, Chronic                            1 (5%)                                                                       
      Follicular Cell, Hyperplasia                                  2 (4%)                                 3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                    (1)                       
      Necrosis                                                                                             1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (20)         (50)                      (20)         (49)                      
      Infiltration Cellular, Lymphocyte                                                                    2 (4%)                   
      Inflammation                                                  1 (2%)                    1 (5%)                                
      Inflammation, Chronic                            5 (25%)                                3 (15%)                               
      Inflammation, Chronic Active                                                                         1 (2%)                   
      Mineralization                                                                                       1 (2%)                   
   Preputial Gland                                    (1)          (6)                                    (4)                       
      Cyst                                             1 (100%)     6 (100%)                               4 (100%)                 
      Infiltration Cellular, Lymphocyte                             1 (17%)                                                         
      Inflammation, Chronic Active                                  2 (33%)                                                         
   Prostate                                           (18)         (45)                      (14)         (49)                      
      Infiltration Cellular, Lymphocyte                             2 (4%)                                 5 (10%)                  
      Inflammation, Chronic Active                                  2 (4%)                    1 (7%)                                
   Testes                                             (20)         (50)                      (20)         (49)                      
      Atrophy                                                                                              1 (2%)                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                                                                       1 (2%)                   
      Polyarteritis                                                 1 (2%)                                                          
      Seminiferous Tubule, Degeneration                                                       1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (20)         (50)                      (20)         (49)                      
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (5)          (50)                      (9)          (48)                      
      Lumbar, Hyperplasia                                           1 (2%)                                                          
   Lymph Node, Bronchial                              (3)          (27)                      (4)          (14)                      
      Hyperplasia                                                                                          2 (14%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mandibular                                          (43)                                   (41)                      
      Hyperplasia                                                                                          1 (2%)                   
   Lymph Node, Mediastinal                            (3)          (22)                      (5)          (9)                       
      Hyperplasia                                                   2 (9%)                                                          
   Lymph Node, Mesenteric                                          (44)                      (1)          (46)                      
      Hyperplasia                                                   1 (2%)                                                          
   Spleen                                             (20)         (50)                      (20)         (49)                      
      Atrophy                                                                                              1 (2%)                   
      Hematopoietic Cell Proliferation                              2 (4%)                                12 (24%)                  
      Hyperplasia, Lymphoid                                         3 (6%)                                 3 (6%)                   
   Thymus                                             (18)         (41)                      (19)         (36)                      
      Atrophy                                                       1 (2%)                                 1 (3%)                   
      Cyst                                                          1 (2%)                                 1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (20)         (49)                      (20)         (49)                      
      Abscess                                                                                              1 (2%)                   
      Alopecia                                                                                             2 (4%)                   
      Cyst                                                          1 (2%)                                 4 (8%)                   
      Infiltration Cellular, Lymphocyte                                                                    2 (4%)                   
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Prepuce, Inflammation, Chronic Active                         2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (50)                      (20)         (49)                      
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Vacuolization Cytoplasmic                                                               6 (30%)                               
      Thalamus, Mineralization                                     28 (56%)                               25 (51%)                  
      Ventricle, Dilatation                                                                                1 (2%)                   
   Peripheral Nerve                                   (20)         (47)                      (19)         (49)                      
      Vacuolization Cytoplasmic                                                               3 (16%)                               
      Sciatic, Infiltration Cellular, Lymphocyte                                                           1 (2%)                   
   Spinal Cord                                        (20)         (49)                      (20)         (49)                      
      Vacuolization Cytoplasmic                        1 (5%)                                 7 (35%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (19)         (49)                      (20)         (48)                      
      Inflammation, Chronic                                                                   2 (10%)                               
      Inflammation, Suppurative                                                                            2 (4%)                   
   Lung                                               (20)         (50)                      (20)         (48)                      
      Adenomatosis                                                  1 (2%)                                 1 (2%)                   
      Hemorrhage                                       2 (10%)                                             1 (2%)                   
      Infiltration Cellular, Histiocyte                1 (5%)       2 (4%)                                 6 (13%)                  
      Inflammation, Chronic                                                                                1 (2%)                   
   Nose                                               (20)         (50)                      (20)         (49)                      
      Inflammation, Acute                              1 (5%)       1 (2%)                                 2 (4%)                   
      Inflammation, Chronic                                                                   2 (10%)                               
      Inflammation, Suppurative                                     1 (2%)                                                          
   Trachea                                            (20)         (49)                      (20)         (48)                      
      Inflammation, Chronic                            1 (5%)                                 3 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)                      (20)         (49)                      
      Infarct                                                       3 (6%)                                 2 (4%)                   
      Infiltration Cellular, Lymphocyte                1 (5%)      19 (38%)                               16 (33%)                  
      Inflammation, Chronic                                        20 (40%)                   2 (10%)      6 (12%)                  
      Cortex, Cyst                                                  7 (14%)                                1 (2%)                   
      Cortex, Infiltration Cellular, Lymphocyte        2 (10%)                                1 (5%)                                
      Cortex, Regeneration                             1 (5%)                                                                       
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                   9 (45%)                               10 (50%)                               
      Medulla, Mineralization                          1 (5%)                                 1 (5%)                                
      Renal Tubule, Casts Protein                                   3 (6%)                    1 (5%)       6 (12%)                  
      Renal Tubule, Degeneration                                                              1 (5%)                                
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Mineralization                     2 (10%)     38 (76%)                   1 (5%)      30 (61%)                  
      Renal Tubule, Regeneration                       4 (20%)                                                                      
      Renal Tubule, Vacuolization Cytoplasmic                       4 (8%)                                 2 (4%)                   
   Urethra                                                         (1)                                                              
      Foreign Body                                                  1 (100%)                                                        
   Urinary Bladder                                    (20)         (49)                      (20)         (49)                      
      Infiltration Cellular, Lymphocyte                6 (30%)      7 (14%)                   7 (35%)      3 (6%)                   
      Inflammation, Chronic                                         2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Polyarteritis                                                 1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          20           50           16           70           16                        
  Scheduled Sacrifice                                 19                         8                         4                        
  Early Deaths                                                                                                                      
    Dead                                               1            3            1           14            4                        
    Moribund Sacrifice                                              5                         2                                     
    Moribund                                                        1            1           37            8                        
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                             40            6           16                                     
    Moribund                                                                                  1                                     
  Animals Examined Microscopically                    20           50            2           70           12                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (12)         (45)         (2)          (54)         (11)                      
      Infiltration Cellular, Lymphocyte                1 (8%)       1 (2%)                                                          
   Intestine Large, Cecum                             (19)         (50)         (2)          (61)         (11)                      
      Hyperplasia, Glandular                           1 (5%)                                                                       
      Hyperplasia, Lymphoid                            1 (5%)                                                                       
   Liver                                              (20)         (50)         (2)          (70)         (12)                      
      Basophilic Focus                                              1 (2%)       1 (50%)      2 (3%)                                
      Clear Cell Focus                                              8 (16%)                                                         
      Hematopoietic Cell Proliferation                 3 (15%)                                1 (1%)                                
      Infiltration Cellular, Lymphocyte                             1 (2%)                    2 (3%)                                
      Inflammation                                                  3 (6%)                    2 (3%)                                
      Mineralization                                                                          1 (1%)                                
      Mixed Cell Focus                                              1 (2%)                                                          
      Necrosis                                         1 (5%)       3 (6%)       2 (100%)     4 (6%)       1 (8%)                   
      Hepatocyte, Vacuolization Cytoplasmic            5 (25%)      7 (14%)                  18 (26%)      5 (42%)                  
      Kupffer Cell, Hyperplasia                                                               1 (1%)                                
   Mesentery                                                       (1)                       (2)                                    
      Fat, Necrosis                                                 1 (100%)                  1 (50%)                               
   Pancreas                                           (20)         (50)         (2)          (70)         (12)                      
      Infiltration Cellular, Lymphocyte                             8 (16%)                   2 (3%)                                
      Acinus, Atrophy                                               2 (4%)                    3 (4%)                                
      Acinus, Degeneration                                                                    1 (1%)       1 (8%)                   
      Acinus, Hyperplasia                                           1 (2%)                                                          
   Salivary Glands                                    (20)         (50)         (2)          (68)         (12)                      
      Infiltration Cellular, Lymphocyte                4 (20%)     24 (48%)      1 (50%)      6 (9%)                                
   Stomach, Glandular                                 (20)         (50)         (2)          (68)         (12)                      
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia                                                   3 (6%)                                                          
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                         1 (2%)                    2 (3%)                                
      Metaplasia                                                                              1 (1%)                                
      Mineralization                                                1 (2%)                    1 (1%)                                
      Necrosis                                                                                1 (1%)       1 (8%)                   
   Tooth                                                           (4)                                                              
      Dysplasia                                                     4 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)         (2)          (70)         (12)                      
      Cardiomyopathy, Chronic                                      10 (20%)      1 (50%)     24 (34%)      1 (8%)                   
      Degeneration                                                                           32 (46%)     10 (83%)                  
      Embolus Bacterial                                             1 (2%)                                                          
      Infiltration Cellular, Mononuclear Cell          3 (15%)                                                                      
      Inflammation, Acute                                           1 (2%)                    2 (3%)                                
      Mineralization                                   1 (5%)                                 2 (3%)                                
      Polyarteritis                                                 1 (2%)                                                          
      Atrium, Thrombosis                                            1 (2%)       1 (50%)      1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (20)         (50)         (2)          (68)         (12)                      
      Spindle Cell, Hyperplasia                        7 (35%)     38 (76%)      1 (50%)     33 (49%)      6 (50%)                  
   Adrenal Gland, Cortex                              (20)         (50)         (2)          (68)         (12)                      
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                      1 (5%)       3 (6%)                    2 (3%)                                
      Hypertrophy                                      1 (5%)       5 (10%)                   3 (4%)                                
      Necrosis                                                      1 (2%)                                                          
      Pigmentation                                                  3 (6%)                                                          
      Vacuolization Cytoplasmic                                    12 (24%)                   4 (6%)                                
   Adrenal Gland, Medulla                             (20)         (50)         (2)          (68)         (12)                      
      Hyperplasia                                                                             1 (1%)                                
   Islets, Pancreatic                                 (20)         (50)         (2)          (70)         (12)                      
      Hyperplasia                                                  17 (34%)                   1 (1%)                                
   Parathyroid Gland                                  (18)         (48)         (1)          (45)         (7)                       
      Cyst                                                          2 (4%)                    1 (2%)                                
   Pituitary Gland                                    (16)         (46)         (2)          (51)         (8)                       
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
   Thyroid Gland                                      (20)         (50)         (1)          (65)         (12)                      
      Cyst                                             1 (5%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (5%)                                                                       
      Follicular Cell, Hyperplasia                                  3 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (20)         (50)         (2)          (69)         (12)                      
      Degeneration                                                                            1 (1%)                                
      Inflammation, Chronic                            3 (15%)                                                                      
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Polyarteritis                                                 1 (2%)                                                          
   Preputial Gland                                    (1)          (9)                       (2)                                    
      Cyst                                             1 (100%)     8 (89%)                   2 (100%)                              
      Inflammation, Chronic Active                                  2 (22%)                                                         
   Prostate                                           (17)         (45)         (2)          (66)         (12)                      
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
   Testes                                             (20)         (50)         (2)          (70)         (12)                      
      Degeneration                                     1 (5%)       1 (2%)                   28 (40%)     10 (83%)                  
      Mineralization                                                2 (4%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (20)         (50)         (2)          (65)         (10)                      
      Hyperplasia, Re Cell                                          1 (2%)                                                          
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node, Bronchial                              (5)          (21)         (1)          (18)         (3)                       
      Hyperplasia                                                   1 (5%)                                                          
   Lymph Node, Mandibular                             (1)          (43)         (1)          (27)         (2)                       
      Hyperplasia                                                   2 (5%)                                                          
      Pigmentation                                                                            1 (4%)                                
   Lymph Node, Mesenteric                                          (41)         (1)          (46)         (7)                       
      Angiectasis                                                   1 (2%)                                                          
      Edema                                                         1 (2%)                                                          
   Spleen                                             (20)         (50)         (2)          (70)         (11)                      
      Atrophy                                          1 (5%)                                10 (14%)      3 (27%)                  
      Degeneration                                                                            1 (1%)                                
      Hematopoietic Cell Proliferation                              9 (18%)      1 (50%)      1 (1%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hyperplasia, Re Cell                                          1 (2%)                                                          
   Thymus                                             (18)         (41)         (1)          (42)         (6)                       
      Atrophy                                                       1 (2%)                   11 (26%)      4 (67%)                  
      Necrosis                                                                                9 (21%)      2 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   21                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (20)         (50)         (2)          (70)         (12)                      
      Abscess                                                       1 (2%)                                                          
      Alopecia                                                      1 (2%)                    1 (1%)                                
      Cyst                                                          3 (6%)                                                          
      Infiltration Cellular, Lymphocyte                                                       1 (1%)                                
      Inflammation, Chronic Active                                  1 (2%)                    2 (3%)                                
      Prepuce, Inflammation, Chronic Active                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (20)         (50)         (2)          (69)         (12)                      
      Sternum, Dysplasia                               1 (5%)       3 (6%)                   14 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (50)         (2)          (70)         (12)                      
      Polyarteritis                                                 1 (2%)       1 (50%)                                            
      Vacuolization Cytoplasmic                        3 (15%)                                                                      
      Cerebellum, Degeneration                                                               31 (44%)      9 (75%)                  
      Cerebrum, Degeneration                                                                 11 (16%)      6 (50%)                  
      Thalamus, Mineralization                                     25 (50%)      1 (50%)     15 (21%)                               
   Spinal Cord                                        (20)         (49)         (2)          (70)         (11)                      
      Vacuolization Cytoplasmic                        4 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (20)         (50)         (1)          (58)         (11)                      
      Inflammation, Acute                              1 (5%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Epithelium, Hyperplasia                                                                              1 (9%)                   
   Lung                                               (20)         (50)         (2)          (70)         (12)                      
      Adenomatosis                                                  2 (4%)                    1 (1%)                                
      Hemorrhage                                                    1 (2%)                    2 (3%)                                
      Infiltration Cellular, Histiocyte                             3 (6%)                                                          
      Inflammation, Chronic                                                                                1 (8%)                   
      Pigmentation                                                  1 (2%)                    1 (1%)                                
      Mediastinum, Inflammation, Acute                                                        1 (1%)                                
   Nose                                               (20)         (50)         (2)          (69)         (12)                      
      Inflammation, Acute                                           5 (10%)                   8 (12%)      1 (8%)                   
      Inflammation, Chronic                            2 (10%)                                                                      
      Inflammation, Suppurative                                     1 (2%)                    2 (3%)                                
      Olfactory Epithelium, Atrophy                                                                        1 (8%)                   
      Olfactory Epithelium, Metaplasia                              1 (2%)                    2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   22                                                              
NTP Experiment-Test: 05101-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:35:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Necrosis                                                          6 (9%)       4 (33%)                  
      Respiratory Epithelium, Metaplasia                                                      1 (1%)       1 (8%)                   
      Respiratory Epithelium, Necrosis                                                        1 (1%)                                
   Trachea                                            (20)         (50)         (1)          (67)         (12)                      
      Inflammation, Chronic                            3 (15%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (1)                                    
      Cornea, Inflammation                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)         (2)          (70)         (12)                      
      Infarct                                                       1 (2%)                    2 (3%)                                
      Infiltration Cellular, Lymphocyte                            18 (36%)                   8 (11%)                               
      Inflammation, Chronic                                        16 (32%)                   3 (4%)       1 (8%)                   
      Polyarteritis                                                              1 (50%)                                            
      Cortex, Cyst                                     1 (5%)       5 (10%)                   2 (3%)                                
      Cortex, Infiltration Cellular, Lymphocyte        1 (5%)                                                                       
      Cortex, Regeneration                             2 (10%)                                                                      
      Interstitium, Infiltration Cellular,                                                                                          
          Lymphocyte                                   7 (35%)                                                                      
      Medulla, Mineralization                          1 (5%)                                                                       
      Renal Tubule, Casts Protein                                   6 (12%)                   5 (7%)                                
      Renal Tubule, Mineralization                                 32 (64%)                   6 (9%)                                
      Renal Tubule, Pigmentation                                    1 (2%)                    1 (1%)                                
      Renal Tubule, Regeneration                       3 (15%)                                                                      
      Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)                                                          
   Urinary Bladder                                    (20)         (47)         (2)          (68)         (12)                      
      Hyperplasia                                                                             1 (1%)                                
      Infiltration Cellular, Lymphocyte                5 (25%)      4 (9%)                    1 (1%)                                
      Inflammation, Chronic                                                                   1 (1%)                                
      Polyarteritis                                                 1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   23                                                              
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                             ----------              END OF REPORT             ----------                                           
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