TDMS Study 05101-01 Pathology Tables
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
Facility: Brookhaven National Laboratory
Chemical CAS #: 74-83-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 4| 4| 4| 0| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 5| 6| 6| 6| 6| 6| 0| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 0| 4| 4| 5| 4| 5| 1| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 8| | A |
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + M + + | 19 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M M M + | 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + M + | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + | 19 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemangiosarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 4| 4| 4| 0| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 5| 6| 6| 6| 6| 6| 0| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 0| 4| 4| 5| 4| 5| 1| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 8| | A |
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + M M M + + M + M M + + + + + M + + + + | 13 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M M M M M M + + + M + M + + M M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + + M + M M M M M + + M M + + M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemangiosarcoma | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + + + + + + M + + + + + + + | 17 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + M M + | 18 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 4| 5| 4| 5| 5| 5| 5| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + M | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M M + + + M M M + M M + M + + + + + M M | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 4| 5| 4| 5| 5| 5| 5| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + M M M M M M + M + + + M + M M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + + + M M M + M M M M M M + + + M M | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + M + M + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + I + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M M + + + + + + M + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M + + M | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + | 19 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + M + M M M M M M M + + + + + M + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + M M M M M M M M + M + + M + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M M M M M M M + M + M + M M M M | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + M + | 18 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + I + + + + + + + + + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 6| 6| 6| 1| 6| 6| 6| 6| 6| 2| | |
| 4| 5| 5| 6| 4| 5| 5| 4| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 6| 6| 6| 1| 6| 6| 6| 6| 6| 2| | |
| 4| 5| 5| 6| 4| 5| 5| 4| 5| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + M M + + + + + + M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M I + M + + + M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M + + + + M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + M + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 7| 2| 2| 3| 2| 2| 3| 0| 3| 2| 3| 2| 2| 2| 1| 2| 2| 2| 3| 2| 2| 3| 2|
| 8| 8| 4| 8| 9| 1| 9| 8| 0| 0| 1| 9| 1| 7| 9| 8| 8| 7| 8| 7| 1| 8| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + M + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma, Metastatic, | |
Spleen | X X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X X |
Lymphoma Malignant Mixed | X |
Acinus, Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 7| 2| 2| 3| 2| 2| 3| 0| 3| 2| 3| 2| 2| 2| 1| 2| 2| 2| 3| 2| 2| 3| 2|
| 8| 8| 4| 8| 9| 1| 9| 8| 0| 0| 1| 9| 1| 7| 9| 8| 8| 7| 8| 7| 1| 8| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Follicular Cell, Adenoma | |
Follicular Cell, Adenoma, Multiple | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyoma | |
Lymphoma Malignant Mixed | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
Carcinoma, Metastatic, Pancreas | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M + + + + + + + + + M + M M + M M + M M + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + + + M|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 7| 2| 2| 3| 2| 2| 3| 0| 3| 2| 3| 2| 2| 2| 1| 2| 2| 2| 3| 2| 2| 3| 2|
| 8| 8| 4| 8| 9| 1| 9| 8| 0| 0| 1| 9| 1| 7| 9| 8| 8| 7| 8| 7| 1| 8| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M + + + + M M M M M M + M M + + M + M + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + M + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + + M + + +|
Carcinoma, Metastatic, Pancreas | |
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + M + + M M M + + + + M + M + M M + + M|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Subcutaneous Tissue, Fibrosarcoma | |
Tail, Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Pancreas | |
Histiocytic Sarcoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 7| 2| 2| 3| 2| 2| 3| 0| 3| 2| 3| 2| 2| 2| 1| 2| 2| 2| 3| 2| 2| 3| 2|
| 8| 8| 4| 8| 9| 1| 9| 8| 0| 0| 1| 9| 1| 7| 9| 8| 8| 7| 8| 7| 1| 8| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Spleen | X X |
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | |
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X | 4 |
Hepatocellular Adenoma | X X | 5 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 2 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 2 |
Lymphoma Malignant Mixed | X X | 3 |
Acinus, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Adenoma | X X X | 5 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Adenoma, Multiple | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | X X | 2 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | X | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 2 |
Leiomyoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Carcinoma, Metastatic, Pancreas | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M M M M + M M + + + + M M + + M + M M M + M| 25 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Lymphoma Malignant Mixed | X X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + M + + + + M + M + +| 42 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 2 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | X | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M M + M M + M M M M + M M M M + M M M +| 18 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + + + + + + + + + + + M + + + + + + + + +| 44 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 3 |
Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 3 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | X | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M + + + + + + + + + + + + + +| 45 |
Carcinoma, Metastatic, Pancreas | X | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Lymphoma Malignant Mixed | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 38 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Tail, Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic, Pancreas | X | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 2 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | X | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Pancreas | X | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | X | 5 |
Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 2| 3| 2| 3| 0| 3| 2| 2| 2| 2| 2| 2| 2| 3| 7| 2| 3| 2|
| 2| 1| 8| 8| 9| 1| 9| 8| 0| 7| 1| 5| 1| 7| 8| 8| 7| 7| 8| 7| 1| 5| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X|
Histiocytic Sarcoma, Metastatic, | |
Uterus | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
Follicular Cell, Adenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 2| 3| 2| 3| 0| 3| 2| 2| 2| 2| 2| 2| 2| 3| 7| 2| 3| 2|
| 2| 1| 8| 8| 9| 1| 9| 8| 0| 7| 1| 5| 1| 7| 8| 8| 7| 7| 8| 7| 1| 5| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M M + + + + M M + M M M + M M M M|
Carcinoma, Metastatic, Kidney | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + M + + + + + + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + + + M + + M M + + M + M M M + M M M M|
Carcinoma, Metastatic, Kidney | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + M + M + M + + + + + + + + + + + + + + + + M +|
Hemangiosarcoma, Metastatic, Heart | X |
Lymphoma Malignant Mixed | X X |
Thymoma NOS | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + + M M + + + + + + + M M M M + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 2| 3| 2| 3| 0| 3| 2| 2| 2| 2| 2| 2| 2| 3| 7| 2| 3| 2|
| 2| 1| 8| 8| 9| 1| 9| 8| 0| 7| 1| 5| 1| 7| 8| 8| 7| 7| 8| 7| 1| 5| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Sciatic, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Liver | X |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Mixed | X X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 7 |
Histiocytic Sarcoma, Metastatic, | | |
Uterus | X | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Kidney | | 1 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Pars Distalis, Adenoma | X X X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Follicular Cell, Adenoma | X X | 3 |
Follicular Cell, Adenoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X | 2 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + + + + M + + + + M M + + M M + + + + +| 32 |
Carcinoma, Metastatic, Kidney | | 1 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + M + M + M M +| 40 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + + M M M + + M M M M M M M + M M + M + +| 17 |
Carcinoma, Metastatic, Kidney | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + M + +| 47 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Thymus | M + + M + + + + + + + + + + M + M + + M + + + M +| 40 |
Hemangiosarcoma, Metastatic, Heart | | 1 |
Lymphoma Malignant Mixed | | 2 |
Thymoma NOS | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + M + + + + + + + M + + M M +| 35 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sciatic, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Carcinoma, Metastatic, Liver | | 1 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant Mixed | | 2 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | X X | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + + + + + + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Polyp Stromal | X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Pancreatic, Histiocytic Sarcoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + M + M M + + + M + M + + M + M + + + M|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M M + + M + + + + + + + M M|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M + M + M M M M M + + M + M + M M + + M|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Marked | |
Hemangiosarcoma, Moderate | |
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + + + M + + + + + + M + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + + M + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X | 2 |
Hepatocellular Adenoma | X X X | 6 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X| 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + M + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cystadenoma | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Polyp Stromal | X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Pancreatic, Histiocytic Sarcoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + M M + M + + M + M M + + + + + + + + M +| 31 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X| 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| 43 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M M M + M M M M M M M M + M M M M M M + +| 14 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X X| 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Marked | X | 1 |
Hemangiosarcoma, Moderate | X | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X X X| 5 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + M + + + M +| 43 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X| 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + M M + + + M M + + + M M M + + +| 38 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X X X| 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + M|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cystadenoma | X X|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + + M + + + + +|
Axillary, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M M + M I + + M M M + M + + M + M + + + M +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + M + + + M + + + + M + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M + M + M M + M M M M M M M M M M M M|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + M + + + + + + + + + M + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + M + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + M + + + + + + M + + + + + + + + +|
Carcinoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Carcinoma, Metastatic, Mammary Gland | X |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + M + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M M + + M M M M + + M M M + M + + + + M +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + M M M + + + + + M + + + M + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M M M M M M M M M M + M M + M M + M +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | M + + + M + + + + M + + + + + + + M + + + + + + M|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + M + M + + + + + + + + M + + + + + + +|
Carcinoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
Gland | |
Carcinoma, Metastatic, Mammary Gland | |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Osteosarcoma, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 4 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Hemangioma | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
Cortex, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + M + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + M + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M M + + + M | 55 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | M + + + + + + + + + | 58 |
Cystadenoma | | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 57 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M M M M M + | 30 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + M M + + + | 46 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M + M M M + + | 13 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 6 |
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + + | 51 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + | 51 |
Carcinoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 59 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + M | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
Osteosarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Lymphoma Malignant Mixed | | 1 |
Osteosarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 7| 4| 1| 7| 1| 7| 4| 1| 7| 4| 7| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 6| 6| 2| 7| 2| 5| 7| 2| 5| 2| 2| | |
| 0| 7| 2| 8| 1| 3| 9| 2| 6| 0| 4| 7| 1| 5| 1| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 7| 4| 1| 7| 1| 7| 4| 1| 7| 4| 7| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 6| 6| 2| 7| 2| 5| 7| 2| 5| 2| 2| | |
| 0| 7| 2| 8| 1| 3| 9| 2| 6| 0| 4| 7| 1| 5| 1| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | + M | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 7| 4| 6| 7| 7| 4| 7| 4| 7| 7| 1| 1| 6| | |
DAY ON TEST | 4| 6| 7| 2| 4| 1| 2| 2| 5| 2| 5| 2| 2| 7| 7| 1| | |
| 8| 9| 1| 0| 9| 3| 1| 0| 4| 1| 4| 2| 0| 6| 7| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | A + | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | M + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + M | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 7| 4| 6| 7| 7| 4| 7| 4| 7| 7| 1| 1| 6| | |
DAY ON TEST | 4| 6| 7| 2| 4| 1| 2| 2| 5| 2| 5| 2| 2| 7| 7| 1| | |
| 8| 9| 1| 0| 9| 3| 1| 0| 4| 1| 4| 2| 0| 6| 7| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | M + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 1 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + M | 1 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Alveolar/Bronchiolar Adenoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + M | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 1| 1| 0| 7| 7| 0| 1| 4| 7| 1| 4| 7| | |
DAY ON TEST | 4| 2| 4| 2| 4| 4| 9| 2| 2| 8| 4| 5| 2| 4| 5| 2| | |
| 7| 2| 9| 1| 2| 2| 3| 2| 0| 6| 3| 4| 1| 3| 4| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 1| 1| 0| 7| 7| 0| 1| 4| 7| 1| 4| 7| | |
DAY ON TEST | 4| 2| 4| 2| 4| 4| 9| 2| 2| 8| 4| 5| 2| 4| 5| 2| | |
| 7| 2| 9| 1| 2| 2| 3| 2| 0| 6| 3| 4| 1| 3| 4| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | M + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| | |
| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 5| 5| 4| 5| 5| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 8| 8| | A |
CONTROL | 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M | 19 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + M + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + M + + + M + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| | |
| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 5| 5| 4| 5| 5| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 8| 8| | A |
CONTROL | 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M + M + M M M + M M M + M M M M M M M + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + M M M + M M M + M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M M M M + M M M M M M M M M M M + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + M + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M + + M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + M + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| | A |
10 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M + | 19 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + | 19 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Hepatocellular Adenoma | X X X | 3 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + | 19 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + I + + M + M + + + + M + | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Prostate | M + M + M + + M M + + + + + + M + + + + | 14 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| | A |
10 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M + M + + I M M M M M M + + + + M M + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M I M M M M M M + M + + M M M + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + M M M M M M M M + M + M M M M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M + + M M M + M M M + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + M + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Alveolar/Bronchiolar Adenoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 0| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 5| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Gallbladder | + M A M + M + M + + M + + + + + M + + M | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + M M + M + + + + + + + | 16 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + M + + M + + + + + + + + + M + + | 17 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 0| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 5| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M + + + + M + + M M M M + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M M M M M M M M + + M + M + M + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + M + + M M M M M + + M + M + M | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + M + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M M M + M M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 2| 2| 3| 2| 2| 9| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 3| 2| 3| 9|
| 9| 0| 0| 0| 8| 8| 0| 9| 7| 2| 8| 9| 9| 7| 0| 0| 8| 7| 7| 0| 8| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X |
Ito Cell Tumor Benign | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
Acinus, Carcinoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + M + + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + M M + + + + + M + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 2| 2| 3| 2| 2| 9| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 3| 2| 3| 9|
| 9| 0| 0| 0| 8| 8| 0| 9| 7| 2| 8| 9| 9| 7| 0| 0| 8| 7| 7| 0| 8| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hepatocellular Carcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + M + + + + |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + M + + + + M + + + + + + M + M + + + + M +|
Carcinoma, Metastatic, Liver | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M + + + + + M M M M M M M M + M M + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + M + + + + M + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + M + + + + + M + + + +|
Carcinoma, Metastatic, Liver | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 2| 2| 3| 2| 2| 9| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 3| 2| 3| 9|
| 9| 0| 0| 0| 8| 8| 0| 9| 7| 2| 8| 9| 9| 7| 0| 0| 8| 7| 7| 0| 8| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Liver | X X X |
Carcinoma, Metastatic, Pancreas | X |
Hepatoblastoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
Carcinoma, Metastatic, Liver | X |
Carcinoma, Metastatic, Pancreas | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 0| 8| 2| 5| 3| 2| 2| 1| 2| 3| 2| 0| 3| 2| 3| 3| 0| 2| 2| 2| 3| 2| |
| 1| 8| 7| 3| 4| 9| 3| 1| 7| 7| 6| 9| 1| 3| 2| 0| 8| 0| 1| 2| 9| 7| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + M + + + + A A + + + + + + + M + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + A + + + M + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + A A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + A A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + M A + + + + + + + + + +| 46 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | X | 1 |
Hepatocellular Carcinoma | X X X X X | 12 |
Hepatocellular Carcinoma, Multiple | X X | 2 |
Hepatocellular Adenoma | X X X X X X X | 12 |
Hepatocellular Adenoma, Multiple | | 5 |
Ito Cell Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Liver | X | 1 |
Acinus, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Liver | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Adenoma | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 0| 8| 2| 5| 3| 2| 2| 1| 2| 3| 2| 0| 3| 2| 3| 3| 0| 2| 2| 2| 3| 2| |
| 1| 8| 7| 3| 4| 9| 3| 1| 7| 7| 6| 9| 1| 3| 2| 0| 8| 0| 1| 2| 9| 7| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Liver | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + M + + + M + + M M + + M + + + + + + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + M + + +| 43 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hepatocellular Carcinoma, Metastatic | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + | 6 |
__________________________________________________________________________|____________|
Prostate | + M + + + + + + + + + + + + + M + + + + M + + + +| 45 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M + + M M M M + + M M M M + + M + M + + M| 27 |
Carcinoma, Metastatic, Liver | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + M + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + M M M M M M M + M + M M + + M + + M M +| 22 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M M M + + + + + + + + +| 44 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thymus | + M + + + + M + M M + + + + + M M + + + + + + + +| 41 |
Carcinoma, Metastatic, Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + M M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcutaneous Tissue, Lipoma | X| 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 0| 8| 2| 5| 3| 2| 2| 1| 2| 3| 2| 0| 3| 2| 3| 3| 0| 2| 2| 2| 3| 2| |
| 1| 8| 7| 3| 4| 9| 3| 1| 7| 7| 6| 9| 1| 3| 2| 0| 8| 0| 1| 2| 9| 7| 9| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + M + + + + + + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X X X | 10 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Carcinoma, Metastatic, Liver | X X X | 6 |
Carcinoma, Metastatic, Pancreas | | 1 |
Hepatoblastoma, Metastatic, Liver | X | 1 |
Hepatocellular Carcinoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic | X | 1 |
Carcinoma, Metastatic, Liver | | 1 |
Carcinoma, Metastatic, Pancreas | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 1| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 3|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 7| 2| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 3| 4| 9| 2| 5|
| 1| 0| 0| 5| 8| 8| 0| 8| 9| 8| 9| 9| 7| 9| 0| 8| 7| 9| 2| 8| 0| 2| 5| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + M + + + A + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + A + A|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + A + +|
Carcinoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
Lymphoma Malignant Mixed | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 1| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 3|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 7| 2| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 3| 4| 9| 2| 5|
| 1| 0| 0| 5| 8| 8| 0| 8| 9| 8| 9| 9| 7| 9| 0| 8| 7| 9| 2| 8| 0| 2| 5| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + M|
Iliac, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + M + M + M M M + + M M M M M M + M M M M M|
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + + + + + M + + M + + + + + + + M + M M|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M M M M M M M M M M M M M + M + M + M M M|
Carcinoma, Metastatic, Liver | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + M + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + M M + + + M + + + + + M M + + + + M|
Carcinoma, Metastatic, Liver | X |
Carcinoma, Metastatic, Lung | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 1| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 3|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 7| 2| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 3| 4| 9| 2| 5|
| 1| 0| 0| 5| 8| 8| 0| 8| 9| 8| 9| 9| 7| 9| 0| 8| 7| 9| 2| 8| 0| 2| 5| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lung | + M + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X X X X X X |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Carcinoma, Metastatic, Liver | X X X X X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Renal Tubule, Adenocarcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Myxoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + M + + + + + + A + + + + | 43 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + | 44 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + | 46 |
Carcinoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + | 46 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hemangioma | X | 1 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X X X X X X | 13 |
Hepatocellular Carcinoma, Multiple | X X | 3 |
Hepatocellular Adenoma | X X X X X X | 13 |
Hepatocellular Adenoma, Multiple | X X X X X | 6 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Carcinoma, Metastatic, Liver | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Carcinoma, Metastatic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + M + + + + + + | 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + M + + + + + + | 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + M + M + + + + + + | 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 4 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Iliac, Lymphoma Malignant Lymphocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M + M M + M M M M + + M + + M M M M M M | 14 |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + | 41 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M + M + + M M + M + M M M M M M M M M | 9 |
Carcinoma, Metastatic, Liver | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + M M + M + + M M + + + + + + M + + + + M + + | 36 |
Carcinoma, Metastatic, Liver | | 1 |
Carcinoma, Metastatic, Lung | | 1 |
Lymphoma Malignant Mixed | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X X X | 6 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X | 8 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Carcinoma, Metastatic, Liver | X X X | 10 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
Adenoma | X X | 2 |
Carcinoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
Renal Tubule, Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Mixed | X | 1 |
Myxoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + M M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X|
Histiocytic Sarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Preputial Gland | + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Axillary, Lymphoma Malignant Mixed | |
Deep Cervical, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | |
Popliteal, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + M M M M + M + M + + M M + M + + M M M M +|
Histiocytic Sarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + + + + + + M + M + + + + + M + + + +|
Histiocytic Sarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M M + M M + M M M M M M M M + M M + M M +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + M + + + + + + + + + M M +|
Histiocytic Sarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M + + + + M + + + + + + M|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Tail, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Carcinoma, Metastatic, Liver | X |
Histiocytic Sarcoma, Metastatic, | |
Intestine Small | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + + + + + + + + + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X X X X | 8 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X X X X| 12 |
Hepatocellular Adenoma, Multiple | X X X X | 5 |
Histiocytic Sarcoma, Metastatic, | | |
Intestine Small | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cortex, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Liver | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + M + + + + + M + + + + + +| 46 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + M + + + + + + M M M + + + + + + + + +| 45 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Axillary, Lymphoma Malignant Mixed | X | 1 |
Deep Cervical, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Popliteal, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M M + + M + + + + M M + + M M M + M M M +| 21 |
Histiocytic Sarcoma, Metastatic, | | |
Intestine Small | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + M + +| 43 |
Histiocytic Sarcoma, Metastatic, | | |
Intestine Small | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M M M M M + M M + M M + M M M M M M| 9 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + M M M + M +| 41 |
Histiocytic Sarcoma, Metastatic, | | |
Intestine Small | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma, Metastatic, | | |
Intestine Small | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + M + + + + M + M + M + + + +| 41 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Tail, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 8 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X X | 5 |
Carcinoma, Metastatic, Liver | X X X | 4 |
Histiocytic Sarcoma, Metastatic, | | |
Intestine Small | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 5| 1| 1| 1| 1| 1| 7| 4| 3| 0| 7| 7| 7| 1| 7| 6| 7| 5| 1| 4| 7| 5| 7| 4| 0|
DAY ON TEST | 4| 3| 3| 3| 2| 3| 2| 9| 8| 8| 3| 3| 3| 3| 2| 8| 2| 9| 7| 8| 2| 5| 3| 1| 8|
| 2| 7| 8| 7| 3| 1| 8| 6| 7| 7| 0| 1| 1| 7| 2| 7| 9| 6| 7| 5| 9| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + A + + M + + + + + + + + + A A + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + M + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + A + + + + + + + + + A A + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + M + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
Hemangioma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + M + + + + + M + M + M + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + M + + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 5| 1| 1| 1| 1| 1| 7| 4| 3| 0| 7| 7| 7| 1| 7| 6| 7| 5| 1| 4| 7| 5| 7| 4| 0|
DAY ON TEST | 4| 3| 3| 3| 2| 3| 2| 9| 8| 8| 3| 3| 3| 3| 2| 8| 2| 9| 7| 8| 2| 5| 3| 1| 8|
| 2| 7| 8| 7| 3| 1| 8| 6| 7| 7| 0| 1| 1| 7| 2| 7| 9| 6| 7| 5| 9| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + M + M + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + I + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | M + + + + M + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + M M M M M M M M + + + M M M M M M M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M M M + + + M M + + M M + + M + + M|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M M + M M M M M M M M M M M + M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + M + + + + + + + + + M + + M M + + + M +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | M + M + M + + + M M M + + + + + M + M M + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic | X |
Carcinoma, Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 5| 1| 1| 1| 1| 1| 7| 4| 3| 0| 7| 7| 7| 1| 7| 6| 7| 5| 1| 4| 7| 5| 7| 4| 0|
DAY ON TEST | 4| 3| 3| 3| 2| 3| 2| 9| 8| 8| 3| 3| 3| 3| 2| 8| 2| 9| 7| 8| 2| 5| 3| 1| 8|
| 2| 7| 8| 7| 3| 1| 8| 6| 7| 7| 0| 1| 1| 7| 2| 7| 9| 6| 7| 5| 9| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 0| 0| 0| 7| 5| 0| 1| 5| 1| 7| 5| 1| 1| 2| 1| 5| 7| 6| 7| 4| 7| 1| 1| 0| 1|
DAY ON TEST | 8| 6| 0| 2| 6| 8| 3| 4| 3| 1| 4| 3| 3| 4| 3| 0| 3| 4| 3| 8| 3| 2| 2| 8| 3|
| 8| 7| 3| 7| 3| 1| 7| 5| 7| 4| 7| 7| 8| 3| 2| 3| 0| 7| 1| 2| 1| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + M + + M|
__________________________________________________________________________|
Gallbladder | + + A + + A + M M + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A A + + + + M + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + |
Hemangioma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + M + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + M + + M + M + M + + + M + M + M M|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + M I + M M + + + M + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + M + + + + M|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 0| 0| 0| 7| 5| 0| 1| 5| 1| 7| 5| 1| 1| 2| 1| 5| 7| 6| 7| 4| 7| 1| 1| 0| 1|
DAY ON TEST | 8| 6| 0| 2| 6| 8| 3| 4| 3| 1| 4| 3| 3| 4| 3| 0| 3| 4| 3| 8| 3| 2| 2| 8| 3|
| 8| 7| 3| 7| 3| 1| 7| 5| 7| 4| 7| 7| 8| 3| 2| 3| 0| 7| 1| 2| 1| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + I + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + M + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | I + M + M + M M + M M M + M M M M M + M + M I + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M M M M + + M M M M + M + M + + + M M M +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M M M + + + M + + M + M M + + M + + M M + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | M M + M + M + + + + M + + M + + + M M M + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + I + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + M + + + I + + M M + + + M + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic | |
Carcinoma, Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
_____________________________________________________________________________________________________________________
| 0| 0| 0| 7| 5| 0| 1| 5| 1| 7| 5| 1| 1| 2| 1| 5| 7| 6| 7| 4| 7| 1| 1| 0| 1|
DAY ON TEST | 8| 6| 0| 2| 6| 8| 3| 4| 3| 1| 4| 3| 3| 4| 3| 0| 3| 4| 3| 8| 3| 2| 2| 8| 3|
| 8| 7| 3| 7| 3| 1| 7| 5| 7| 4| 7| 7| 8| 3| 2| 3| 0| 7| 1| 2| 1| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 1| 7| 3| 0| 0| 0| 0| 3| 1| 1| 7| 1| 1| 2| 1| 1| 7| | |
DAY ON TEST | 2| 1| 3| 3| 2| 8| 7| 8| 8| 8| 6| 3| 3| 3| 3| 3| 8| 3| 8| 2| | |
| 9| 8| 1| 0| 7| 8| 5| 8| 0| 2| 8| 7| 1| 1| 7| 1| 7| 7| 4| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + A + + A + + A + + A + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + A + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + A + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + A + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + A + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 4 |
Hepatocellular Adenoma | X X X | 6 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hemangioma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + | 68 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + M M M + M M + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + M M M M + + + I + + + + I M + | 51 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + M + + + + + + + + + + + + | 65 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 1| 7| 3| 0| 0| 0| 0| 3| 1| 1| 7| 1| 1| 2| 1| 1| 7| | |
DAY ON TEST | 2| 1| 3| 3| 2| 8| 7| 8| 8| 8| 6| 3| 3| 3| 3| 3| 8| 3| 8| 2| | |
| 9| 8| 1| 0| 7| 8| 5| 8| 0| 2| 8| 7| 1| 1| 7| 1| 7| 7| 4| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + M + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + I + + + + + I + + | 65 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + M M + + + + M M + M + | 58 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M M I + + M M M M M + M M M M + | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M M M M M M + M + M M M M M + | 27 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M M M M M M M M M M M M M M M M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + M + + + M M + + M + M M + M + | 46 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + M M M M M + + + + + + + + M | 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M + M M M M + M + M M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + M + + M + + I + + + M + | 66 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 1| 7| 3| 0| 0| 0| 0| 3| 1| 1| 7| 1| 1| 2| 1| 1| 7| | |
DAY ON TEST | 2| 1| 3| 3| 2| 8| 7| 8| 8| 8| 6| 3| 3| 3| 3| 3| 8| 3| 8| 2| | |
| 9| 8| 1| 0| 7| 8| 5| 8| 0| 2| 8| 7| 1| 1| 7| 1| 7| 7| 4| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + M + I + + + M + + + + I + + I + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic | | 1 |
Carcinoma, Metastatic, Liver | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + I + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + I + + + + + + + + + + + + | 67 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + | 68 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 70 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 4| 7| 1| 4| 1| 7| 6| 4| 1| 5| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 4| 2| 7| 5| 7| 2| 2| 5| 7| 4| 2| | |
| 0| 7| 0| 0| 0| 8| 0| 1| 4| 7| 2| 9| 5| 6| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
Jejunum, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | M + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 4| 7| 1| 4| 1| 7| 6| 4| 1| 5| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 4| 2| 7| 5| 7| 2| 2| 5| 7| 4| 2| | |
| 0| 7| 0| 0| 0| 8| 0| 1| 4| 7| 2| 9| 5| 6| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | M + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M + | 1 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | M + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 4| 7| 1| 4| 1| 7| 6| 4| 1| 5| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 4| 2| 7| 5| 7| 2| 2| 5| 7| 4| 2| | |
| 0| 7| 0| 0| 0| 8| 0| 1| 4| 7| 2| 9| 5| 6| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| 3| 0| 4| 1| 1| 1| | |
DAY ON TEST | 3| 4| 8| 4| 3| 3| 3| 4| 7| 4| 5| 8| 1| 4| 3| 2| | |
| 0| 2| 0| 2| 1| 0| 7| 0| 5| 3| 4| 0| 8| 3| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + M M + M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + I M + + M I + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 05101-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC METHYL BROMIDE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:37:09
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| 3| 0| 4| 1| 1| 1| | |
DAY ON TEST | 3| 4| 8| 4| 3| 3| 3| 4| 7| 4| 5| 8| 1| 4| 3| 2| | |
| 0| 2| 0| 2| 1| 0| 7| 0| 5| 3| 4| 0| 8| 3| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + I + + I + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + M M + + M + M + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M M + M M + M I M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M + M M + M M M | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M + M M M M M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M M + M M + M + + | 7 |
__________________________________________________________________________|____________|
Spleen | M + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Thymus | M M + + + + M M M M + + | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + M + + + + + | 11 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + I + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + M + + + | 11 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
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