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https://ntp.niehs.nih.gov/go/1687

TDMS Study 05101-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           METHYL BROMIDE


NTP Experiment-Test: 05101-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01




       Facility:  Brookhaven National Laboratory

       Chemical CAS #:  74-83-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          21           50           15           20           50           16           
  Scheduled Sacrifice                                 19                         9           20                         7           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            4                                      5            1           
    Dead                                               1            6                                      3            1           
    Moribund                                                        3                                      1                        
  Survivors                                                                                                                         
    Moribund Sacrifice                                              1                                                               
    Terminal Sacrifice                                             36            6                        41            7           
  Animals Examined Microscopically                    20           50                        20           50            2           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (20)         (50)                      (20)         (50)         (2)          
   Intestine Small, Ileum                             (20)         (49)                      (20)         (50)         (2)          
   Liver                                              (20)         (50)                      (20)         (50)         (2)          
      Hepatocellular Carcinoma                                      4 (8%)                                 3 (6%)                   
      Hepatocellular Carcinoma, Multiple                                                                   1 (2%)                   
      Hepatocellular Adenoma                                        5 (10%)                                7 (14%)      1 (50%)     
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Spleen                       2 (4%)                                                          
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                 1 (2%)                   
   Pancreas                                           (20)         (50)                      (20)         (50)         (2)          
      Histiocytic Sarcoma, Metastatic, Spleen                       2 (4%)                                                          
      Acinus, Carcinoma                                             1 (2%)                                                          
   Salivary Glands                                    (20)         (49)                      (20)         (49)         (2)          
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (2%)                                                          
   Stomach                                            (20)         (50)                      (20)         (50)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)                      (20)         (50)         (2)          
      Carcinoma, Metastatic, Kidney                                                                        1 (2%)                   
      Hemangiosarcoma                                                                                      1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (19)         (50)                      (20)         (50)         (2)          
      Carcinoma, Metastatic, Kidney                                                                        1 (2%)                   
   Adrenal Gland, Medulla                             (19)         (50)                      (20)         (50)         (2)          
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Pituitary Gland                                    (18)         (49)                      (18)         (48)         (2)          
      Pars Distalis, Adenoma                                        5 (10%)                                4 (8%)                   
      Pars Distalis, Carcinoma                                      1 (2%)                                                          
   Thyroid Gland                                      (19)         (49)                      (20)         (49)         (2)          
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (2%)                                                          
      Follicular Cell, Adenoma                                      1 (2%)                                 3 (6%)                   
      Follicular Cell, Adenoma, Multiple                            1 (2%)                                 1 (2%)                   
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (20)         (50)                      (20)         (49)         (2)          
      Cystadenoma                                                   2 (4%)                                                          
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
   Uterus                                             (20)         (50)                      (20)         (50)         (2)          
      Histiocytic Sarcoma                                           2 (4%)                                 2 (4%)                   
      Leiomyoma                                                     1 (2%)                                                          
      Polyp Stromal                                                 1 (2%)                                 1 (2%)       1 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (20)         (50)                      (20)         (50)         (2)          
      Hemangiosarcoma                                  1 (5%)                                                                       
   Lymph Node                                         (13)         (49)                      (10)         (50)         (2)          
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
   Lymph Node, Bronchial                              (7)          (25)                      (7)          (32)                      
      Carcinoma, Metastatic, Kidney                                                                        1 (3%)                   
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (4%)                                                          
   Lymph Node, Mandibular                             (1)          (42)                                   (40)         (1)          
      Histiocytic Sarcoma, Metastatic, Spleen                       2 (5%)                                                          
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
   Lymph Node, Mediastinal                            (7)          (18)                      (7)          (17)                      
      Carcinoma, Metastatic, Kidney                                                                        1 (6%)                   
                                                             Page   3                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (6%)                                                          
   Lymph Node, Mesenteric                                          (44)                                   (47)         (1)          
      Histiocytic Sarcoma, Metastatic, Spleen                       3 (7%)                                                          
   Spleen                                             (20)         (50)                      (20)         (50)         (2)          
      Hemangiosarcoma                                  1 (5%)                                              1 (2%)                   
      Histiocytic Sarcoma                                           3 (6%)                                                          
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
   Thymus                                             (20)         (45)                      (19)         (40)         (1)          
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Heart                                                                   1 (3%)                   
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (2%)                                                          
      Thymoma NOS                                                                                          2 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (17)         (38)                      (17)         (35)         (2)          
      Adenocarcinoma                                                1 (3%)                                                          
   Skin                                               (20)         (50)                      (20)         (50)         (2)          
      Fibrosarcoma                                                                                         1 (2%)                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Tail, Keratoacanthoma                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (20)         (50)                      (20)         (50)         (2)          
      Osteosarcoma                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (50)                      (20)         (50)         (2)          
   Peripheral Nerve                                   (20)         (49)                      (20)         (50)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (50)                      (20)         (50)         (2)          
      Alveolar/Bronchiolar Adenoma                                  3 (6%)                                 2 (4%)                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                 2 (4%)                   
      Carcinoma, Metastatic, Liver                                                                         1 (2%)                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                                                       1 (2%)                   
      Histiocytic Sarcoma, Metastatic, Spleen                       2 (4%)                                                          
      Histiocytic Sarcoma, Metastatic, Uterus                       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                                                       1 (2%)                   
                                                             Page   4                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)                                    (1)                       
      Adenoma                                                       1 (100%)                               1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)                      (20)         (50)         (2)          
      Carcinoma, Metastatic                                                                                1 (2%)                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (2%)                                                          
   Urinary Bladder                                    (20)         (50)                      (19)         (50)         (2)          
      Histiocytic Sarcoma, Metastatic, Spleen                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(20)        *(50)                     *(20)        *(50)        *(2)          
      Histiocytic Sarcoma                                           5 (10%)                                2 (4%)                   
      Lymphoma Malignant Mixed                                      4 (8%)                                 4 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             1          27                                  29           2               
     Total Primary Neoplasms                            2          42                                  37           2               
                                                                                                                                    
   Total Animals with Benign Neoplasms                             16                                  16           2               
     Total Benign Neoplasms                                        23                                  19           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1          16                                  15                           
     Total Malignant Neoplasms                          2          19                                  16                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          6                                   6                           
     Total Metastatic Neoplasm                                     29                                  10                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                  2                           
     Total Uncertain Neoplasms                                                                          2                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          20           50           16           10           60           16           
  Scheduled Sacrifice                                 20                         8            8                         8           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              3                                      4                        
    Dead                                                            1            1                         4                        
    Moribund                                                        1            1            2           12            2           
  Survivors                                                                                                                         
    Terminal Sacrifice                                             45            6                        40            6           
  Animals Examined Microscopically                    20           50            2           10           60            2           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (17)         (49)         (1)          (10)         (58)         (2)          
   Intestine Large, Cecum                             (20)         (50)         (2)          (10)         (58)         (2)          
   Intestine Large, Colon                             (20)         (50)         (2)          (10)         (60)         (2)          
   Intestine Small, Duodenum                          (20)         (50)         (2)          (10)         (58)         (2)          
      Adenoma                                                       1 (2%)                                                          
   Intestine Small, Ileum                             (20)         (49)         (2)          (10)         (58)         (2)          
   Liver                                              (20)         (50)         (2)          (10)         (60)         (2)          
      Hepatocellular Carcinoma                                      2 (4%)                                 1 (2%)                   
      Hepatocellular Adenoma                                        6 (12%)                                4 (7%)                   
      Hepatocellular Adenoma, Multiple                              1 (2%)                                 1 (2%)                   
      Histiocytic Sarcoma                                           1 (2%)                                 1 (2%)                   
   Pancreas                                           (20)         (50)         (2)          (10)         (60)         (2)          
      Hemangioma                                                                                           1 (2%)                   
      Histiocytic Sarcoma, Metastatic, Liver                                                               1 (2%)                   
   Salivary Glands                                    (20)         (50)         (2)          (10)         (60)         (2)          
   Stomach                                            (20)         (50)         (2)          (10)         (60)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)         (2)          (10)         (59)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (50)         (2)          (10)         (59)         (2)          
   Adrenal Gland, Medulla                             (20)         (50)         (2)          (10)         (59)         (2)          
      Pheochromocytoma Benign                          1 (5%)                                                                       
   Islets, Pancreatic                                 (20)         (50)         (2)          (10)         (60)         (2)          
      Adenoma                                                                                              1 (2%)                   
                                                             Page   7                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (19)         (48)         (1)          (10)         (55)         (2)          
      Pars Distalis, Adenoma                                        2 (4%)                                 1 (2%)                   
   Thyroid Gland                                      (20)         (50)         (1)          (9)          (60)         (2)          
      Follicular Cell, Adenoma                                      2 (4%)                                 2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (20)         (50)         (2)          (10)         (58)         (2)          
      Cystadenoma                                                   1 (2%)                                 3 (5%)                   
   Uterus                                             (20)         (50)         (2)          (10)         (60)         (2)          
      Polyp Stromal                                                 3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (20)         (50)         (2)          (10)         (60)         (2)          
   Lymph Node                                         (11)         (50)         (2)          (7)          (57)         (2)          
      Pancreatic, Histiocytic Sarcoma, Metastatic,                                                                                  
           Liver                                                    1 (2%)                                                          
   Lymph Node, Bronchial                              (7)          (31)         (1)          (4)          (30)         (1)          
   Lymph Node, Mandibular                                          (43)                                   (46)         (1)          
   Lymph Node, Mediastinal                            (5)          (14)                      (5)          (13)                      
   Lymph Node, Mesenteric                                          (48)         (2)          (1)          (55)         (1)          
      Histiocytic Sarcoma, Metastatic, Liver                                                               1 (2%)                   
   Spleen                                             (20)         (50)         (2)          (10)         (60)         (2)          
      Hemangiosarcoma                                                                                      1 (2%)                   
      Hemangiosarcoma, Marked                                       1 (2%)                                                          
      Hemangiosarcoma, Moderate                                     1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Liver                        1 (2%)                                 1 (2%)                   
   Thymus                                             (20)         (43)         (1)          (9)          (51)         (1)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (18)         (38)         (1)          (10)         (51)         (2)          
      Carcinoma                                                                                            1 (2%)                   
   Skin                                               (20)         (50)         (2)          (10)         (60)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                                        (1)                       
      Sarcoma                                                                                              1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (50)         (2)          (10)         (60)         (2)          
   Spinal Cord                                        (20)         (50)         (2)          (10)         (59)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (50)         (2)          (10)         (60)         (2)          
      Alveolar/Bronchiolar Adenoma                                               1 (50%)                   6 (10%)                  
      Alveolar/Bronchiolar Adenoma, Multiple                                                               1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                 1 (2%)                   
      Carcinoma, Metastatic, Harderian Gland                                                               1 (2%)                   
      Carcinoma, Metastatic, Mammary Gland                                                                 1 (2%)                   
      Histiocytic Sarcoma, Metastatic, Liver                                                               1 (2%)                   
      Osteosarcoma, Metastatic                                                                             1 (2%)                   
   Nose                                               (20)         (50)         (2)          (10)         (60)         (2)          
      Osteosarcoma, Metastatic                                                                             1 (2%)                   
   Trachea                                            (19)         (50)         (2)          (9)          (60)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                                                        (1)                       
      Carcinoma                                                                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)         (2)          (10)         (60)         (2)          
      Histiocytic Sarcoma, Metastatic, Liver                        1 (2%)                                 1 (2%)                   
   Urinary Bladder                                    (20)         (50)         (1)          (10)         (59)         (2)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(20)        *(50)        *(2)         *(10)        *(60)        *(2)          
      Histiocytic Sarcoma                                           1 (2%)                                 1 (2%)                   
      Lymphoma Malignant Lymphocytic                                3 (6%)                                 1 (2%)                   
      Lymphoma Malignant Mixed                                      5 (10%)                                6 (10%)                  
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        33 PPM       33 PPM       33 PPM       100 PPM      100 PPM      100 PPM         
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             1          27           1                      27                           
     Total Primary Neoplasms                            1          31           1                      34                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                  1          15           1                      18                           
     Total Benign Neoplasms                             1          16           1                      20                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                          15                                  14                           
     Total Malignant Neoplasms                                     15                                  14                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1                                   4                           
     Total Metastatic Neoplasm                                      3                                   9                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          20           50           16           20           49           16           
  Scheduled Sacrifice                                 20                        10           19                         8           
  Early Deaths                                                                                                                      
    Dead                                                            5                         1            8                        
    Moribund Sacrifice                                              2                                      4                        
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                             40            6                        37            8           
    Dead                                                            1                                                               
    Moribund Sacrifice                                              1                                                               
  Animals Examined Microscopically                    20           50                        20           49                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (20)         (44)                      (19)         (43)                      
   Intestine Large, Cecum                             (20)         (48)                      (19)         (47)                      
   Intestine Small, Duodenum                          (20)         (46)                      (19)         (44)                      
   Intestine Small, Ileum                             (20)         (46)                      (19)         (46)                      
      Carcinoma                                                                                            1 (2%)                   
   Intestine Small, Jejunum                           (20)         (46)                      (19)         (46)                      
   Liver                                              (20)         (50)                      (20)         (49)                      
      Hemangioma                                                                                           1 (2%)                   
      Hepatoblastoma                                                1 (2%)                                 1 (2%)                   
      Hepatocellular Carcinoma                         1 (5%)      12 (24%)                               13 (27%)                  
      Hepatocellular Carcinoma, Multiple                            2 (4%)                                 3 (6%)                   
      Hepatocellular Adenoma                           1 (5%)      12 (24%)                   3 (15%)     13 (27%)                  
      Hepatocellular Adenoma, Multiple                              5 (10%)                                6 (12%)                  
      Ito Cell Tumor Benign                                         1 (2%)                                                          
   Pancreas                                           (20)         (50)                      (20)         (49)                      
      Carcinoma, Metastatic, Liver                                  1 (2%)                                 1 (2%)                   
      Acinus, Carcinoma                                             1 (2%)                                                          
   Salivary Glands                                    (20)         (50)                      (20)         (49)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)                      (20)         (49)                      
      Carcinoma, Metastatic                                                                                1 (2%)                   
      Carcinoma, Metastatic, Liver                                  1 (2%)                                                          
      Sarcoma                                                                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  11                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (49)                      (20)         (47)                      
      Adenoma                                                       1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
   Islets, Pancreatic                                 (20)         (50)                      (20)         (49)                      
      Carcinoma, Metastatic, Liver                                  1 (2%)                                                          
   Thyroid Gland                                      (20)         (49)                      (20)         (48)                      
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                    (1)                       
      Hepatocellular Carcinoma, Metastatic                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (20)         (50)                      (20)         (49)                      
   Prostate                                           (18)         (45)                      (14)         (49)                      
   Seminal Vesicle                                    (20)         (50)                      (20)         (49)                      
   Testes                                             (20)         (50)                      (20)         (49)                      
      Interstitial Cell, Adenoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (20)         (50)                      (20)         (49)                      
   Lymph Node                                         (5)          (50)                      (9)          (48)                      
   Lymph Node, Bronchial                              (3)          (27)                      (4)          (14)                      
      Carcinoma, Metastatic, Liver                                  2 (7%)                                                          
      Carcinoma, Metastatic, Lung                                                                          1 (7%)                   
   Lymph Node, Mandibular                                          (43)                                   (41)                      
   Lymph Node, Mediastinal                            (3)          (22)                      (5)          (9)                       
      Carcinoma, Metastatic, Liver                                                                         1 (11%)                  
   Lymph Node, Mesenteric                                          (44)                      (1)          (46)                      
   Spleen                                             (20)         (50)                      (20)         (49)                      
   Thymus                                             (18)         (41)                      (19)         (36)                      
      Carcinoma, Metastatic, Liver                                  1 (2%)                                 1 (3%)                   
      Carcinoma, Metastatic, Lung                                                                          1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (20)         (49)                      (20)         (49)                      
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (19)         (49)                      (20)         (48)                      
   Lung                                               (20)         (50)                      (20)         (48)                      
      Alveolar/Bronchiolar Adenoma                                 10 (20%)                   1 (5%)       6 (13%)                  
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (4%)                                 2 (4%)                   
      Alveolar/Bronchiolar Carcinoma                                2 (4%)                                 8 (17%)                  
      Carcinoma, Metastatic, Harderian Gland                                                               1 (2%)                   
      Carcinoma, Metastatic, Liver                                  6 (12%)                               10 (21%)                  
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic                          1 (2%)                                                          
   Trachea                                            (20)         (49)                      (20)         (48)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)                                    (4)                       
      Adenoma                                                       2 (100%)                               2 (50%)                  
      Carcinoma                                                                                            2 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)                      (20)         (49)                      
      Carcinoma, Metastatic                                         1 (2%)                                                          
      Carcinoma, Metastatic, Liver                                  1 (2%)                                                          
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Renal Tubule, Adenocarcinoma                                                                         1 (2%)                   
   Urinary Bladder                                    (20)         (49)                      (20)         (49)                      
                                                             Page  13                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Myxoma                                                                                               1 (2%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(20)        *(50)                     *(20)        *(49)                      
      Lymphoma Malignant Lymphocytic                                1 (2%)                                 1 (2%)                   
      Lymphoma Malignant Mixed                                      1 (2%)                                 2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      CONTROL      CONTROL      10 PPM       10 PPM       10 PPM          
                                                   INTERIM      TERMINAL     NEURO        INTERIM      TERMINAL     NEURO           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             2          37                       3          41                           
     Total Primary Neoplasms                            2          56                       4          64                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                  1          29                       3          25                           
     Total Benign Neoplasms                             1          36                       4          31                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1          16                                  28                           
     Total Malignant Neoplasms                          1          20                                  33                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          7                                  11                           
     Total Metastatic Neoplasm                                     20                                  17                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          20           50           16           70           16                        
  Scheduled Sacrifice                                 19                         8                         4                        
  Early Deaths                                                                                                                      
    Dead                                               1            3            1           14            4                        
    Moribund Sacrifice                                              5                         2                                     
    Moribund                                                        1            1           37            8                        
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                             40            6           16                                     
    Moribund                                                                                  1                                     
  Animals Examined Microscopically                    20           50            2           70           12                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (19)         (50)         (2)          (61)         (11)                      
   Intestine Small, Ileum                             (19)         (50)         (2)          (61)         (11)                      
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Liver                                              (20)         (50)         (2)          (70)         (12)                      
      Hemangiosarcoma                                               1 (2%)                    1 (1%)                                
      Hepatocellular Carcinoma                                      8 (16%)                   4 (6%)                                
      Hepatocellular Carcinoma, Multiple                            2 (4%)                                                          
      Hepatocellular Adenoma                                       12 (24%)                   6 (9%)                                
      Hepatocellular Adenoma, Multiple                              5 (10%)                   1 (1%)                                
      Histiocytic Sarcoma, Metastatic, Intestine                                                                                    
          Small                                                     1 (2%)                                                          
   Mesentery                                                       (1)                       (2)                                    
      Hemangioma                                                                              1 (50%)                               
   Pancreas                                           (20)         (50)         (2)          (70)         (12)                      
   Salivary Glands                                    (20)         (50)         (2)          (68)         (12)                      
   Stomach                                            (20)         (50)         (2)          (68)         (12)                      
   Stomach, Forestomach                               (20)         (50)         (2)          (68)         (12)                      
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (20)         (50)         (2)          (70)         (12)                      
      Carcinoma, Metastatic, Liver                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  16                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (50)         (2)          (68)         (12)                      
   Adrenal Gland, Medulla                             (20)         (50)         (2)          (68)         (12)                      
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Islets, Pancreatic                                 (20)         (50)         (2)          (70)         (12)                      
      Adenoma                                                       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (20)         (50)         (2)          (69)         (12)                      
   Prostate                                           (17)         (45)         (2)          (66)         (12)                      
   Seminal Vesicle                                    (20)         (50)         (2)          (70)         (12)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (14)         (50)         (2)          (58)         (8)                       
   Lymph Node, Bronchial                              (5)          (21)         (1)          (18)         (3)                       
      Histiocytic Sarcoma, Metastatic, Intestine                                                                                    
          Small                                                     1 (5%)                                                          
   Lymph Node, Mandibular                             (1)          (43)         (1)          (27)         (2)                       
      Histiocytic Sarcoma, Metastatic, Intestine                                                                                    
          Small                                                     1 (2%)                                                          
   Lymph Node, Mediastinal                            (9)          (9)          (1)          (4)          (1)                       
   Lymph Node, Mesenteric                                          (41)         (1)          (46)         (7)                       
      Histiocytic Sarcoma, Metastatic, Intestine                                                                                    
          Small                                                     1 (2%)                                                          
   Spleen                                             (20)         (50)         (2)          (70)         (11)                      
      Hemangiosarcoma, Metastatic, Liver                                                      1 (1%)                                
      Histiocytic Sarcoma, Metastatic, Intestine                                                                                    
          Small                                                     1 (2%)                                                          
   Thymus                                             (18)         (41)         (1)          (42)         (6)                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (20)         (50)         (2)          (70)         (12)                      
      Hemangiosarcoma, Metastatic, Liver                                                      1 (1%)                                
      Tail, Sarcoma                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page  17                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (50)         (2)          (70)         (12)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (50)         (2)          (70)         (12)                      
      Alveolar/Bronchiolar Adenoma                                  8 (16%)                   4 (6%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma                   1 (5%)       5 (10%)                   1 (1%)                                
      Carcinoma, Metastatic                                                                   1 (1%)                                
      Carcinoma, Metastatic, Liver                                  4 (8%)                    1 (1%)                                
      Histiocytic Sarcoma, Metastatic, Intestine                                                                                    
          Small                                                     1 (2%)                                                          
   Nose                                               (20)         (50)         (2)          (69)         (12)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)                                                              
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (50)         (2)          (70)         (12)                      
   Urinary Bladder                                    (20)         (47)         (2)          (68)         (12)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(20)        *(50)        *(2)         *(70)        *(12)                      
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
      Lymphoma Malignant Mixed                                      3 (6%)                    1 (1%)                                
      Lymphoma Malignant Undifferentiated Cell                      2 (4%)       1 (50%)      1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  18                                                               
NTP Experiment-Test: 05101-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYL BROMIDE                                      Date: 09/13/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 18:38:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          33 PPM       33 PPM       33 PPM       100 PPM      100 PPM                      
                                                   INTERIM      TERMINAL     NEURO        TERMINAL     NEURO                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             1          38           1          16                                       
     Total Primary Neoplasms                            1          56           1          20                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                             28                      10                                       
     Total Benign Neoplasms                                        31                      12                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1          21           1           8                                       
     Total Malignant Neoplasms                          1          25           1           8                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          5                       3                                       
     Total Metastatic Neoplasm                                     11                       4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  19                                                               
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                             ----------              END OF REPORT             ----------                                           
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