TDMS Study 05101-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Brookhaven METHYL BROMIDE DATE: 09/13/94
EXPERIMENT: 05101 TEST: 01 TIME: 19:07:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: Y-01200-87 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 04148B
PATHOLOGIST: S. EUSTIS M. GARY RILEY CAS: 74-83-9
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Brookhaven METHYL BROMIDE DATE: 09/13/94
EXPERIMENT: 05101 TEST: 01 TIME: 19:07:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: Y-01200-87 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 04148B
PATHOLOGIST: S. EUSTIS M. GARY RILEY CAS: 74-83-9
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Brookhaven METHYL BROMIDE DATE: 09/13/94
EXPERIMENT: 05101 TEST: 01 TIME: 19:07:13
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: Y-01200-87 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 04148B
PATHOLOGIST: S. EUSTIS M. GARY RILEY CAS: 74-83-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF METHYL BROMIDE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Carcinoma or Adenoma
All Organs Histiocytic Sarcoma
====================================================================================================
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/69 (3%) 1/72 (1%) 0/82 (0%) | 1/70 (1%) 1/72 (1%) 0/72 (0%) 0/72 (0%) |
|ADJUSTED (b) | 4.4% 5.4% 2.5% 0.0% | 2.8% 2.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 2/37 (5%) 1/40 (3%) 0/16 (0%) | 1/36 (3%) 0/41 (0%) 0/45 (0%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | 603 727 (T) 727 (T) --- | 727 (T) 577 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292N P=0.666 P=0.511N P=0.443N | P=0.296N P=0.738N P=0.455N P=0.479N |
|INCIDENTAL TUMOR | P=0.200N P=0.690N P=0.457N P=0.186N | P=0.269N P=0.669N P=0.455N P=0.479N |
|LOGISTIC REGRESSION | P=0.250N P=0.677 P=0.498N P=0.355N | P=0.302N P=0.752N P=0.455N P=0.479N |
|COCHRAN-ARMITAGE | P=0.117N | P=0.302N |
|FISHER EXACT | P=0.685 P=0.489N P=0.210N | P=0.745N P=0.493N P=0.493N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/69 (3%) 0/72 (0%) 0/82 (0%) | 0/70 (0%) 0/72 (0%) 0/72 (0%) 1/72 (1%) |
|ADJUSTED (b) | 0.0% 5.1% 0.0% 0.0% | 0.0% 0.0% 0.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 1/37 (3%) 0/40 (0%) 0/16 (0%) | 0/36 (0%) 0/41 (0%) 0/45 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- 695 --- --- | --- --- --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.537N P=0.224 (e) (e) | P=0.216 (e) (e) P=0.521 |
|INCIDENTAL TUMOR | P=0.481N P=0.251 (e) (e) | P=0.216 (e) (e) P=0.521 |
|LOGISTIC REGRESSION | P=0.510N P=0.224 (e) (e) | P=0.216 (e) (e) P=0.521 |
|COCHRAN-ARMITAGE | P=0.340N | P=0.217 |
|FISHER EXACT | P=0.245 (e) (e) | (e) (e) P=0.507 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 4/69 (6%) 1/72 (1%) 0/82 (0%) | 1/70 (1%) 1/72 (1%) 0/72 (0%) 1/72 (1%) |
|ADJUSTED (b) | 4.4% 10.3% 2.5% 0.0% | 2.8% 2.1% 0.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 3/37 (8%) 1/40 (3%) 0/16 (0%) | 1/36 (3%) 0/41 (0%) 0/45 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 603 695 727 (T) --- | 727 (T) 577 --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.205N P=0.308 P=0.511N P=0.443N | P=0.688 P=0.738N P=0.455N P=0.738N |
|INCIDENTAL TUMOR | P=0.132N P=0.348 P=0.457N P=0.186N | P=0.673N P=0.669N P=0.455N P=0.738N |
|LOGISTIC REGRESSION | P=0.169N P=0.313 P=0.498N P=0.355N | P=0.680 P=0.752N P=0.455N P=0.738N |
|COCHRAN-ARMITAGE | P=0.061N | P=0.680 |
|FISHER EXACT | P=0.333 P=0.489N P=0.210N | P=0.745N P=0.493N P=0.745N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 2/72 (3%) 0/82 (0%) | 0/70 (0%) 0/72 (0%) 0/72 (0%) 1/72 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 4.9% 0.0% | 0.0% 0.0% 0.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 0/37 (0%) 1/40 (3%) 0/16 (0%) | 0/36 (0%) 0/41 (0%) 0/45 (0%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- 690 --- | --- --- --- 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.651 (e) P=0.232 (e) | P=0.216 (e) (e) P=0.521 |
|INCIDENTAL TUMOR | P=0.682 (e) P=0.185 (e) | P=0.216 (e) (e) P=0.521 |
|LOGISTIC REGRESSION | P=0.672 (e) P=0.234 (e) | P=0.216 (e) (e) P=0.521 |
|COCHRAN-ARMITAGE | P=0.655N | P=0.217 |
|FISHER EXACT | (e) P=0.255 (e) | (e) (e) P=0.507 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/70 (26%) 22/69 (32%) 17/72 (24%) 7/82 (9%) | 6/70 (9%) 8/72 (11%) 7/72 (10%) 5/72 (7%) |
|ADJUSTED (b) | 41.4% 52.7% 40.2% 34.8% | 16.7% 18.4% 15.6% 11.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 3/9 (33%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 15/40 (38%) 18/37 (49%) 15/40 (38%) 4/16 (25%) | 6/36 (17%) 7/41 (17%) 7/45 (16%) 4/40 (10%) |
|FIRST INCIDENCE (DAYS) | 464 (I) 464 (I) 520 542 | 727 (T) 428 727 (T) 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.425N P=0.180 P=0.501N P=0.599 | P=0.290N P=0.487 P=0.567N P=0.429N |
|INCIDENTAL TUMOR | P=0.203N P=0.198 P=0.546N P=0.337N | P=0.287N P=0.469 P=0.567N P=0.391N |
|LOGISTIC REGRESSION | P=0.159N P=0.208 P=0.519N P=0.339N | P=0.315N P=0.429 P=0.567N P=0.475N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.315N |
|FISHER EXACT | P=0.269 P=0.462N P=0.004N** | P=0.411 P=0.522 P=0.480N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/70 (21%) 16/69 (23%) 10/72 (14%) 4/82 (5%) | 4/70 (6%) 4/72 (6%) 2/72 (3%) 1/72 (1%) |
|ADJUSTED (b) | 32.9% 37.1% 22.4% 21.9% | 10.7% 9.8% 4.4% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 10/40 (25%) 10/37 (27%) 6/40 (15%) 3/16 (19%) | 3/36 (8%) 4/41 (10%) 2/45 (4%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 465 (I) 566 481 542 | 708 727 (T) 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.401 P=0.205N P=0.339N | P=0.098N P=0.576N P=0.246N P=0.156N |
|INCIDENTAL TUMOR | P=0.019N* P=0.491 P=0.187N P=0.115N | P=0.102N P=0.639 P=0.302N P=0.179N |
|LOGISTIC REGRESSION | P=0.031N* P=0.463 P=0.181N P=0.148N | P=0.105N P=0.610N P=0.264N P=0.168N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.109N |
|FISHER EXACT | P=0.482 P=0.169N P=0.002N** | P=0.625N P=0.327N P=0.174N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/70 (21%) 17/69 (25%) 10/72 (14%) 4/82 (5%) | 4/70 (6%) 4/72 (6%) 2/72 (3%) 1/72 (1%) |
|ADJUSTED (b) | 32.9% 38.3% 22.4% 21.9% | 10.7% 9.8% 4.4% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 10/40 (25%) 10/37 (27%) 6/40 (15%) 3/16 (19%) | 3/36 (8%) 4/41 (10%) 2/45 (4%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 465 (I) 442 481 542 | 708 727 (T) 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.142N P=0.328 P=0.205N P=0.339N | P=0.098N P=0.576N P=0.246N P=0.156N |
|INCIDENTAL TUMOR | P=0.009N** P=0.404 P=0.187N P=0.115N | P=0.102N P=0.639 P=0.302N P=0.179N |
|LOGISTIC REGRESSION | P=0.027N* P=0.349 P=0.181N P=0.148N | P=0.105N P=0.610N P=0.264N P=0.168N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.109N |
|FISHER EXACT | P=0.402 P=0.169N P=0.002N** | P=0.625N P=0.327N P=0.174N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/70 (43%) 34/69 (49%) 26/72 (36%) 9/82 (11%) | 10/70 (14%) 12/72 (17%) 8/72 (11%) 6/72 (8%) |
|ADJUSTED (b) | 62.2% 72.1% 56.3% 45.6% | 26.9% 28.0% 17.8% 14.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 3/9 (33%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 22/40 (55%) 24/37 (65%) 20/40 (50%) 6/16 (38%) | 9/36 (25%) 11/41 (27%) 8/45 (18%) 5/40 (13%) |
|FIRST INCIDENCE (DAYS) | 464 (I) 464 (I) 481 542 | 708 428 727 (T) 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.112N P=0.173 P=0.313N P=0.290N | P=0.081N P=0.535 P=0.217N P=0.152N |
|INCIDENTAL TUMOR | P=0.003N** P=0.204 P=0.326N P=0.045N* | P=0.082N P=0.470 P=0.250N P=0.145N |
|LOGISTIC REGRESSION | P=0.003N** P=0.176 P=0.280N P=0.046N* | P=0.094N P=0.462 P=0.248N P=0.183N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.101N |
|FISHER EXACT | P=0.278 P=0.258N P<0.001N** | P=0.437 P=0.376N P=0.196N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 30/70 (43%) 35/69 (51%) 26/72 (36%) 9/82 (11%) | 10/70 (14%) 12/72 (17%) 8/72 (11%) 6/72 (8%) |
|ADJUSTED (b) | 62.2% 72.7% 56.3% 45.6% | 26.9% 28.0% 17.8% 14.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 3/9 (33%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 22/40 (55%) 24/37 (65%) 20/40 (50%) 6/16 (38%) | 9/36 (25%) 11/41 (27%) 8/45 (18%) 5/40 (13%) |
|FIRST INCIDENCE (DAYS) | 464 (I) 442 481 542 | 708 428 727 (T) 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.100N P=0.136 P=0.313N P=0.290N | P=0.081N P=0.535 P=0.217N P=0.152N |
|INCIDENTAL TUMOR | P=0.002N** P=0.156 P=0.326N P=0.045N* | P=0.082N P=0.470 P=0.250N P=0.145N |
|LOGISTIC REGRESSION | P=0.003N** P=0.133 P=0.280N P=0.046N* | P=0.094N P=0.462 P=0.248N P=0.183N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.101N |
|FISHER EXACT | P=0.224 P=0.258N P<0.001N** | P=0.437 P=0.376N P=0.196N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/70 (17%) 9/68 (13%) 10/72 (14%) 4/82 (5%) | 3/70 (4%) 2/72 (3%) 1/72 (1%) 7/72 (10%) |
|ADJUSTED (b) | 28.3% 23.2% 23.4% 18.7% | 8.3% 4.7% 2.0% 17.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/9 (11%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 10/40 (25%) 8/37 (22%) 8/40 (20%) 2/16 (13%) | 3/36 (8%) 1/41 (2%) 0/45 (0%) 6/40 (15%) |
|FIRST INCIDENCE (DAYS) | 653 465 (I) 481 485 | 727 (T) 643 611 658 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.462N P=0.389N P=0.413N P=0.440N | P=0.033 * P=0.449N P=0.236N P=0.200 |
|INCIDENTAL TUMOR | P=0.168N P=0.364N P=0.457N P=0.172N | P=0.039 * P=0.392N P=0.196N P=0.181 |
|LOGISTIC REGRESSION | P=0.292N P=0.369N P=0.418N P=0.304N | P=0.030 * P=0.475N P=0.261N P=0.171 |
|COCHRAN-ARMITAGE | P=0.013N* | P=0.034 * |
|FISHER EXACT | P=0.345N P=0.381N P=0.014N* | P=0.487N P=0.299N P=0.175 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 8/68 (12%) 6/72 (8%) 1/82 (1%) | 1/70 (1%) 2/72 (3%) 1/72 (1%) 1/72 (1%) |
|ADJUSTED (b) | 4.5% 20.2% 14.1% 6.3% | 2.7% 4.9% 2.2% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 1/10 (10%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/40 (3%) 6/37 (16%) 5/40 (13%) 1/16 (6%) | 0/36 (0%) 2/41 (5%) 1/45 (2%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | 484 625 465 (I) 727 (T) | 720 727 (T) 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.486N P=0.040 * P=0.139 P=0.714 | P=0.522N P=0.542 P=0.713N P=0.740N |
|INCIDENTAL TUMOR | P=0.280N P=0.035 * P=0.155 P=0.539N | P=0.529N P=0.411 P=0.715 P=0.729 |
|LOGISTIC REGRESSION | P=0.335N P=0.040 * P=0.140 P=0.681N | P=0.536N P=0.522 P=0.726N P=0.755N |
|COCHRAN-ARMITAGE | P=0.065N | P=0.530N |
|FISHER EXACT | P=0.044 * P=0.147 P=0.441N | P=0.511 P=0.745N P=0.745N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/70 (20%) 15/68 (22%) 15/72 (21%) 5/82 (6%) | 4/70 (6%) 4/72 (6%) 2/72 (3%) 7/72 (10%) |
|ADJUSTED (b) | 32.1% 36.9% 34.2% 24.5% | 10.8% 9.4% 4.1% 17.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/9 (11%) 1/10 (10%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 11/40 (28%) 12/37 (32%) 12/40 (30%) 3/16 (19%) | 3/36 (8%) 3/41 (7%) 1/45 (2%) 6/40 (15%) |
|FIRST INCIDENCE (DAYS) | 484 465 (I) 465 (I) 485 | 720 643 611 658 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.432N P=0.405 P=0.496 P=0.454N | P=0.155 P=0.577N P=0.249N P=0.319 |
|INCIDENTAL TUMOR | P=0.099N P=0.414 P=0.470 P=0.126N | P=0.167 P=0.614N P=0.270N P=0.268 |
|LOGISTIC REGRESSION | P=0.208N P=0.426 P=0.499 P=0.289N | P=0.141 P=0.613N P=0.276N P=0.279 |
|COCHRAN-ARMITAGE | P=0.003N** | P=0.152 |
|FISHER EXACT | P=0.465 P=0.534 P=0.009N** | P=0.625N P=0.327N P=0.283 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/70 (3%) 0/71 (0%) 1/72 (1%) 3/70 (4%) |
|ADJUSTED (b) | | 5.6% 0.0% 2.2% 7.5% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | | 2/36 (6%) 0/40 (0%) 1/45 (2%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | | 727 (T) --- 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.193 P=0.215N P=0.422N P=0.548 |
|INCIDENTAL TUMOR | | P=0.193 P=0.215N P=0.422N P=0.548 |
|LOGISTIC REGRESSION | | P=0.193 P=0.215N P=0.422N P=0.548 |
|COCHRAN-ARMITAGE | | P=0.181 |
|FISHER EXACT | | P=0.245N P=0.489N P=0.500 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/63 (0%) 0/63 (0%) 0/67 (0%) 0/59 (0%) | 5/68 (7%) 4/70 (6%) 2/69 (3%) 1/67 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 13.5% 9.3% 4.2% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/37 (0%) 0/13 (0%) | 4/36 (11%) 2/41 (5%) 0/44 (0%) 1/39 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 720 643 681 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.072N P=0.434N P=0.153N P=0.088N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.061N P=0.621N P=0.281N P=0.104N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.056N P=0.477N P=0.172N P=0.098N |
|COCHRAN-ARMITAGE | (e) | P=0.080N |
|FISHER EXACT | (e) (e) (e) | P=0.482N P=0.214N P=0.108N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/63 (0%) 0/63 (0%) 0/67 (0%) 0/59 (0%) | 6/68 (9%) 4/70 (6%) 2/69 (3%) 1/67 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 16.2% 9.3% 4.2% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/37 (0%) 0/13 (0%) | 5/36 (14%) 2/41 (5%) 0/44 (0%) 1/39 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 720 643 681 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.047N* P=0.306N P=0.087N P=0.048N* |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.039N* P=0.469N P=0.167N P=0.057N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.037N* P=0.346N P=0.099N P=0.054N |
|COCHRAN-ARMITAGE | (e) | P=0.053N |
|FISHER EXACT | (e) (e) (e) | P=0.354N P=0.132N P=0.060N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/72 (0%) 0/81 (0%) | 1/70 (1%) 1/72 (1%) 2/72 (3%) 1/72 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 1.8% 2.4% 4.4% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 0/37 (0%) 0/40 (0%) 0/16 (0%) | 0/36 (0%) 1/41 (2%) 2/45 (4%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 464 (I) 727 (T) 727 (T) 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.641N P=0.734N P=0.564 P=0.755 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.621N P=0.734N P=0.564 P=0.701N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.637N P=0.755N P=0.524 P=0.754N |
|COCHRAN-ARMITAGE | (e) | P=0.634N |
|FISHER EXACT | (e) (e) (e) | P=0.745N P=0.511 P=0.745N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Thymus |
| Thymoma NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/61 (0%) 0/55 (0%) 0/61 (0%) 0/48 (0%) | 0/65 (0%) 2/61 (3%) 0/64 (0%) 0/61 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 5.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/33 (0%) 0/28 (0%) 0/34 (0%) 0/10 (0%) | 0/33 (0%) 1/31 (3%) 0/38 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 643 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.369N P=0.238 (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.336N P=0.306 (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.378N P=0.217 (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.379N |
|FISHER EXACT | (e) (e) (e) | P=0.232 (e) (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/69 (1%) 0/68 (0%) 0/71 (0%) 0/77 (0%) | 2/69 (3%) 4/71 (6%) 2/71 (3%) 2/71 (3%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% 0.0% | 5.6% 9.8% 4.4% 5.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/40 (3%) 0/37 (0%) 0/40 (0%) 0/16 (0%) | 2/36 (6%) 4/41 (10%) 2/45 (4%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- --- --- | 727 (T) 727 (T) 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.612N P=0.516N P=0.500N P=0.682N | P=0.418N P=0.398 P=0.612N P=0.657N |
|INCIDENTAL TUMOR | P=0.612N P=0.516N P=0.500N P=0.682N | P=0.418N P=0.398 P=0.612N P=0.657N |
|LOGISTIC REGRESSION | P=0.612N P=0.516N P=0.500N P=0.682N | P=0.418N P=0.398 P=0.612N P=0.657N |
|COCHRAN-ARMITAGE | P=0.459N | P=0.433N |
|FISHER EXACT | P=0.504N P=0.493N P=0.473N | P=0.354 P=0.679N P=0.679N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/69 (1%) 0/68 (0%) 0/71 (0%) 0/77 (0%) | 3/69 (4%) 4/71 (6%) 2/71 (3%) 2/71 (3%) |
|ADJUSTED (b) | 2.5% 0.0% 0.0% 0.0% | 8.3% 9.8% 4.4% 5.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/40 (3%) 0/37 (0%) 0/40 (0%) 0/16 (0%) | 3/36 (8%) 4/41 (10%) 2/45 (4%) 2/40 (5%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- --- --- | 727 (T) 727 (T) 727 (T) 727 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.612N P=0.516N P=0.500N P=0.682N | P=0.311N P=0.571 P=0.399N P=0.452N |
|INCIDENTAL TUMOR | P=0.612N P=0.516N P=0.500N P=0.682N | P=0.311N P=0.571 P=0.399N P=0.452N |
|LOGISTIC REGRESSION | P=0.612N P=0.516N P=0.500N P=0.682N | P=0.311N P=0.571 P=0.399N P=0.452N |
|COCHRAN-ARMITAGE | P=0.459N | P=0.328N |
|FISHER EXACT | P=0.504N P=0.493N P=0.473N | P=0.516 P=0.486N P=0.486N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/70 (1%) 2/72 (3%) 3/72 (4%) 0/72 (0%) |
|ADJUSTED (b) | | 2.8% 4.1% 6.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | | 1/36 (3%) 1/41 (2%) 3/45 (7%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | | 727 (T) 463 727 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.241N P=0.538 P=0.388 P=0.479N |
|INCIDENTAL TUMOR | | P=0.254N P=0.504 P=0.388 P=0.479N |
|LOGISTIC REGRESSION | | P=0.250N P=0.515 P=0.388 P=0.479N |
|COCHRAN-ARMITAGE | | P=0.251N |
|FISHER EXACT | | P=0.511 P=0.321 P=0.493N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 1/72 (1%) 1/82 (1%) | 1/70 (1%) 2/72 (3%) 2/72 (3%) 1/72 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% 5.9% | 1.8% 4.5% 4.4% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 0/37 (0%) 1/40 (3%) 0/16 (0%) | 0/36 (0%) 1/41 (2%) 2/45 (4%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) 722 | 464 (I) 505 727 (T) 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.129 (e) P=0.500 P=0.325 | P=0.519N P=0.535 P=0.564 P=0.755 |
|INCIDENTAL TUMOR | P=0.187 (e) P=0.500 P=0.455 | P=0.510N P=0.501 P=0.564 P=0.701N |
|LOGISTIC REGRESSION | P=0.133 (e) P=0.500 P=0.332 | P=0.517N P=0.509 P=0.524 P=0.754N |
|COCHRAN-ARMITAGE | P=0.345 | P=0.515N |
|FISHER EXACT | (e) P=0.507 P=0.539 | P=0.511 P=0.511 P=0.745N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 1/69 (1%) 1/72 (1%) 2/82 (2%) | 1/70 (1%) 2/72 (3%) 2/72 (3%) 2/72 (3%) |
|ADJUSTED (b) | 0.0% 2.7% 2.5% 11.8% | 1.8% 4.5% 4.4% 4.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 1/37 (3%) 1/40 (3%) 1/16 (6%) | 0/36 (0%) 1/41 (2%) 2/45 (4%) 1/40 (3%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) 727 (T) 722 | 464 (I) 505 727 (T) 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.036 * P=0.484 P=0.500 P=0.075 | P=0.496 P=0.535 P=0.564 P=0.506 |
|INCIDENTAL TUMOR | P=0.055 P=0.484 P=0.500 P=0.126 | P=0.504 P=0.501 P=0.564 P=0.576 |
|LOGISTIC REGRESSION | P=0.039 * P=0.484 P=0.500 P=0.077 | P=0.495 P=0.509 P=0.524 P=0.509 |
|COCHRAN-ARMITAGE | P=0.242 | P=0.498 |
|FISHER EXACT | P=0.496 P=0.507 P=0.289 | P=0.511 P=0.511 P=0.511 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 1/72 (1%) 0/82 (0%) | 5/70 (7%) 2/72 (3%) 1/72 (1%) 1/72 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 2.5% 0.0% | 12.0% 4.9% 2.2% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/40 (0%) 0/37 (0%) 1/40 (3%) 0/16 (0%) | 2/36 (6%) 2/41 (5%) 1/45 (2%) 0/40 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) --- | 500 727 (T) 727 (T) 655 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.794 (e) P=0.500 (e) | P=0.113N P=0.186N P=0.071N P=0.099N |
|INCIDENTAL TUMOR | P=0.794 (e) P=0.500 (e) | P=0.118N P=0.218N P=0.140N P=0.107N |
|LOGISTIC REGRESSION | P=0.794 (e) P=0.500 (e) | P=0.089N P=0.199N P=0.084N P=0.048N* |
|COCHRAN-ARMITAGE | P=0.758N | P=0.116N |
|FISHER EXACT | (e) P=0.507 (e) | P=0.209N P=0.098N P=0.098N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/69 (3%) 8/72 (11%) 2/82 (2%) | 9/70 (13%) 6/72 (8%) 10/72 (14%) 8/72 (11%) |
|ADJUSTED (b) | 4.5% 4.4% 17.9% 11.5% | 19.9% 14.1% 21.2% 16.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/40 (3%) 1/37 (3%) 5/40 (13%) 1/16 (6%) | 3/36 (8%) 5/41 (12%) 8/45 (18%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | 484 420 543 714 | 430 622 640 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.214 P=0.666 P=0.055 P=0.391 | P=0.553N P=0.239N P=0.519N P=0.449N |
|INCIDENTAL TUMOR | P=0.469N P=0.694 P=0.099 P=0.665 | P=0.436N P=0.217N P=0.342 P=0.328N |
|LOGISTIC REGRESSION | P=0.376 P=0.689 P=0.052 P=0.477 | P=0.552 P=0.235N P=0.601 P=0.476N |
|COCHRAN-ARMITAGE | P=0.444N | P=0.559 |
|FISHER EXACT | P=0.685 P=0.053 P=0.628N | P=0.273N P=0.527 P=0.475N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/69 (3%) 7/72 (10%) 2/82 (2%) | 4/70 (6%) 4/72 (6%) 9/72 (13%) 7/72 (10%) |
|ADJUSTED (b) | 4.5% 4.4% 15.6% 11.5% | 8.8% 9.3% 19.1% 14.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 1/40 (3%) 1/37 (3%) 4/40 (10%) 1/16 (6%) | 1/36 (3%) 3/41 (7%) 7/45 (16%) 3/40 (8%) |
|FIRST INCIDENCE (DAYS) | 484 420 543 714 | 430 622 640 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.228 P=0.666 P=0.091 P=0.391 | P=0.234 P=0.591N P=0.215 P=0.310 |
|INCIDENTAL TUMOR | P=0.442N P=0.694 P=0.159 P=0.665 | P=0.342 P=0.545N P=0.061 P=0.443 |
|LOGISTIC REGRESSION | P=0.398 P=0.689 P=0.152 P=0.477 | P=0.215 P=0.620N P=0.162 P=0.281 |
|COCHRAN-ARMITAGE | P=0.457N | P=0.223 |
|FISHER EXACT | P=0.685 P=0.090 P=0.628N | P=0.625N P=0.133 P=0.283 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/70 (43%) 28/69 (41%) 28/72 (39%) 10/82 (12%) | 16/70 (23%) 18/72 (25%) 17/72 (24%) 18/72 (25%) |
|ADJUSTED (b) | 66.4% 67.7% 63.4% 47.4% | 42.0% 38.3% 33.5% 42.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 3/9 (33%) 0/10 (0%) 0/0 | 0/9 (0%) 0/10 (0%) 1/10 (10%) 0/8 (0%) |
|TERMINAL (d) | 25/40 (63%) 24/37 (65%) 24/40 (60%) 6/16 (38%) | 14/36 (39%) 13/41 (32%) 12/45 (27%) 16/40 (40%) |
|FIRST INCIDENCE (DAYS) | 464 (I) 464 (I) 481 485 | 707 428 465 (I) 578 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.291N P=0.554 P=0.431N P=0.340N | P=0.489 P=0.579 P=0.385N P=0.555 |
|INCIDENTAL TUMOR | P=0.047N* P=0.560N P=0.453N P=0.057N | P=0.510 P=0.475 P=0.477N P=0.527 |
|LOGISTIC REGRESSION | P=0.063N P=0.547N P=0.438N P=0.090N | P=0.454 P=0.492 P=0.476N P=0.462 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.467 |
|FISHER EXACT | P=0.460N P=0.378N P<0.001N** | P=0.459 P=0.537 P=0.459 |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 33 PPM 100 PPM | CONTROL 10 PPM 33 PPM 100 PPM |
| | NEURO NEURO NEURO NEURO | NEURO NEURO NEURO NEURO |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 17/70 (24%) 28/69 (41%) 23/72 (32%) 9/82 (11%) | 17/70 (24%) 15/72 (21%) 15/72 (21%) 14/72 (19%) |
|ADJUSTED (b) | 36.4% 60.5% 46.5% 43.3% | 36.1% 32.6% 31.9% 28.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 0/9 (0%) 1/10 (10%) 0/0 | 1/9 (11%) 0/10 (0%) 0/10 (0%) 0/8 (0%) |
|TERMINAL (d) | 11/40 (28%) 19/37 (51%) 14/40 (35%) 5/16 (31%) | 7/36 (19%) 11/41 (27%) 13/45 (29%) 6/40 (15%) |
|FIRST INCIDENCE (DAYS) | 465 (I) 420 465 (I) 496 | 430 428 640 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.520 P=0.021 * P=0.186 P=0.305 | P=0.324N P=0.313N P=0.215N P=0.292N |
|INCIDENTAL TUMOR | P=0.023N* P=0.016 * P=0.238 P=0.389N | P=0.230N P=0.413N P=0.535N P=0.224N |
|LOGISTIC REGRESSION | P=0.142N P=0.015 * P=0.303 P=0.588 | P=0.338N P=0.338N P=0.277N P=0.296N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.332N |
|FISHER EXACT | P=0.030 * P=0.204 P=0.025N* | P=0.385N P=0.385N P=0.310N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 39/70 (56%) 44/69 (64%) 40/72 (56%) 17/82 (21%) | 28/70 (40%) 31/72 (43%) 29/72 (40%) 27/72 (38%) |
|ADJUSTED (b) | 79.4% 87.9% 78.3% 72.9% | 59.2% 61.4% 55.6% 55.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 3/9 (33%) 1/10 (10%) 0/0 | 1/9 (11%) 0/10 (0%) 1/10 (10%) 0/8 (0%) |
|TERMINAL (d) | 30/40 (75%) 31/37 (84%) 29/40 (73%) 10/16 (63%) | 17/36 (47%) 22/41 (54%) 22/45 (49%) 19/40 (48%) |
|FIRST INCIDENCE (DAYS) | 464 (I) 420 465 (I) 485 | 430 428 465 (I) 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.532 P=0.104 P=0.493 P=0.394 | P=0.315N P=0.555N P=0.276N P=0.364N |
|INCIDENTAL TUMOR | P=0.002N** P=0.096 P=0.582 P=0.110N | P=0.202N P=0.403 P=0.536 P=0.329N |
|LOGISTIC REGRESSION | P=0.022N* P=0.083 P=0.487N P=0.227N | P=0.333N P=0.477 P=0.399N P=0.433N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.333N |
|FISHER EXACT | P=0.213 P=0.560N P<0.001N** | P=0.421 P=0.555 P=0.447N |
|=================================================================================================================================|
DATE: 09/13/94 EXPERIMENT: 05101 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- METHYL BROMIDE
TERMINAL SACRIFICE AT 104 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 183 464
Female interim sacrifices(days): 183 464
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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