TDMS Study 05101-01 Pathology Tables
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
Facility: Brookhaven National Laboratory
Chemical CAS #: 74-83-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 4| 4| 4| 0| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 5| 6| 6| 6| 6| 6| 0| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 0| 4| 4| 5| 4| 5| 1| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 8| | A |
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + M + + | 19 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Necrosis, Focal | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Degeneration | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + | 19 |
Spindle Cell, Hyperplasia | 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 | 18 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M M M + | 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + M + | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 4| 4| 4| 0| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 5| 6| 6| 6| 6| 6| 0| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 0| 4| 4| 5| 4| 5| 1| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 8| | A |
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 3 2 2 2 | 9 2.2|
Endothelium, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + M M M + + M + M M + + + + + M + + + + | 13 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M M M M M M + + + M + M + + M M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 1 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + + M + M M M M M + + M M + + M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M + + + + + + + + M + + + + + + + | 17 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
Ectopic Tissue | X | 1 |
Vacuolization Cytoplasmic | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + M M + | 18 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 3| 4| 4| 4| 4| 4| 0| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 5| 6| 6| 6| 6| 6| 0| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 0| 4| 4| 5| 4| 5| 1| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 8| | A |
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Olfactory Epithelium, Atypia Cellular| 1 1 1 | 3 1.0|
Respiratory Epithelium, Atypia | | |
Cellular | 1 2 1 1 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 | 2 1.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 2 1 1 1 1 1 1 1 2 1 | 10 1.2|
Renal Tubule, Casts Protein | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 4| 5| 4| 5| 5| 5| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 1 | 7 1.1|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 1 2 1 2 | 19 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + I + + + + + + + + + + M | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 4| 5| 4| 5| 5| 5| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 20 |
Cyst | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 2 2 2 2 1 | 10 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M M + + + M M M + M M + M + + + + + M M | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + + M M M M M M + M + + + M + M M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + + + M M M + M M M M M M + + + M M | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + M + M + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 3 2 3 3 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 2 1 2 2 2 2 2 | 7 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Olfactory Epithelium, Atypia Cellular| 1 2 1 | 3 1.3|
Respiratory Epithelium, Atypia | | |
Cellular | 1 2 2 2 1 1 2 | 7 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 4| 5| 4| 5| 5| 5| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 2 1 1 | 3 1.3|
Cortex, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 2 1.0|
Interstitium, Infiltration Cellular | 2 | 1 2.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 1 1 1 1 1 2 | 6 1.2|
Renal Tubule, Casts Protein | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + I + + + + + + + + + + + + + + + | 19 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M M + + + + + + M + + + | 17 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Lymphoid | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 | 8 1.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Acute | 1 | 1 1.0|
Necrosis, Focal | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Spindle Cell, Hyperplasia | 2 2 2 1 1 2 2 1 2 2 3 1 1 2 2 1 2 2 2 | 19 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M + + M | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + | 19 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 20 |
Cyst | X | 1 |
Germinal Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 20 |
Endometrium, Hyperplasia, Cystic | 3 3 1 2 2 2 2 2 2 2 | 10 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | + + M + M M M M M M M + + + + + M + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + M M M M M M M M + M + + M + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M M M M M M M + M + M + M M M M | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + M + | 18 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
Sternum, Dysplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 2 1 1 1 1 1 | 9 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + + + + + + + + + + + + | 19 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 | 1 1.0|
Olfactory Epithelium, Atypia Cellular| 1 1 1 1 | 4 1.0|
Respiratory Epithelium, Atypia | | |
Cellular | 2 1 1 1 2 2 | 6 1.5|
__________________________________________________________________________|____________|
Trachea | + + + I + + + + + + + + + + + + + + + + | 19 |
Inflammation, Chronic | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Cortex, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 2 1 1 2 1 1 1 1 1 | 9 1.2|
Renal Tubule, Casts Protein | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 6| 6| 6| 1| 6| 6| 6| 6| 6| 2| | |
| 4| 5| 5| 6| 4| 5| 5| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | X | 1 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 2 | 1 2.0|
Degeneration | 2 1 3 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
Spindle Cell, Hyperplasia | 2 2 1 1 2 2 2 1 2 1 | 10 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 6| 6| 6| 1| 6| 6| 6| 6| 6| 2| | |
| 4| 5| 5| 6| 4| 5| 5| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Endometrium, Hyperplasia, Cystic | 2 1 2 1 2 1 2 2 | 8 1.6|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + M M + + + + + + M | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M I + M + + + M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M + + + + M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 9 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
Sternum, Dysplasia | 2 | 1 2.0|
Turbinate, Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
Cerebellum, Degeneration | 2 2 1 1 | 4 1.5|
Cerebrum, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + + | 9 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 4| 4| 1| | |
DAY ON TEST | 6| 6| 6| 1| 6| 6| 6| 6| 6| 2| | |
| 4| 5| 5| 6| 4| 5| 5| 4| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + M + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Renal Tubule, Regeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 7| 2| 2| 3| 2| 2| 3| 0| 3| 2| 3| 2| 2| 2| 1| 2| 2| 2| 3| 2| 2| 3| 2|
| 8| 8| 4| 8| 9| 1| 9| 8| 0| 0| 1| 9| 1| 7| 9| 8| 8| 7| 8| 7| 1| 8| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + M + + + M + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Clear Cell Focus | 2 1 |
Eosinophilic Focus | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 2 1|
Inflammation | 1 2 2 |
Mixed Cell Focus | 2 |
Thrombosis | X |
__________________________________________________________________________|
Mesentery | + |
Cyst | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 1 2 2 1 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 1 1 1 1 2 1 2 1 1 1 2 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | |
Degeneration | |
Polyarteritis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 1 2 2 3 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 7| 2| 2| 3| 2| 2| 3| 0| 3| 2| 3| 2| 2| 2| 1| 2| 2| 2| 3| 2| 2| 3| 2|
| 8| 8| 4| 8| 9| 1| 9| 8| 0| 0| 1| 9| 1| 7| 9| 8| 8| 7| 8| 7| 1| 8| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 2 |
Hyperplasia | 1 1 |
Hypertrophy | |
Pigmentation | 1 1 2 2 2|
Vacuolization Cytoplasmic | 3 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M + + + + + + M + + + + + M + +|
Cyst | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 |
Polyarteritis | |
Follicular Cell, Hyperplasia | 1 3 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 3 2 2 |
Pigmentation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 1 3 2 3 3 3 2 3 2 2 2 3 2 3 2 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 2 3 1 2 1 2 2 1 1 2 3 2 3 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M + + + + + + + + + M + M M + M M + M M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M + + + + + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M + + + + M M M M M M + M M + + M + M + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + M + +|
Edema | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 9| 7| 2| 2| 3| 2| 2| 3| 0| 3| 2| 3| 2| 2| 2| 1| 2| 2| 2| 3| 2| 2| 3| 2|
| 8| 8| 4| 8| 9| 1| 9| 8| 0| 0| 1| 9| 1| 7| 9| 8| 8| 7| 8| 7| 1| 8| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 2 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + + M + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + M + + M M M + + + + M + M + M M + + M|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 |
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 1 1 1 1 2 1 1 1 2 2 1 1 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 2 2 1 1 1 1|
Inflammation, Chronic | |
Metaplasia, Osseous | |
Polyarteritis | |
Renal Tubule, Mineralization | 1 1 |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 2 1 1 1 1 2 1 1 |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 | 3 2.3|
Clear Cell Focus | 1| 3 1.3|
Eosinophilic Focus | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 | 11 1.4|
Inflammation | 2 2 2 1 | 7 1.7|
Mixed Cell Focus | 2 | 2 2.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Cyst | | 1 2.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 2 1 1 2 2 1 2 | 19 1.5|
Acinus, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 1 2 1 2 1 1 2 1 1 2 1 1| 35 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 | 2 1.0|
Degeneration | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Polyarteritis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spindle Cell, Hyperplasia | 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 47 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 3 1.7|
Hyperplasia | 3 | 3 1.7|
Hypertrophy | 2 1 | 2 1.5|
Pigmentation | 3 1 1 1 | 9 1.6|
Vacuolization Cytoplasmic | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 2 | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 45 |
Cyst | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 2| 2 1.5|
Pars Distalis, Hyperplasia | 3 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Polyarteritis | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 1 1| 7 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1| 8 2.3|
Pigmentation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 1 1 2 2 2 3 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 1| 45 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 1 1 1 1 1 1 3 2 1 2 1 2 2 1 2| 33 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Iliac, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M M M M + M M + + + + M M + + M + M M M + M| 25 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + M + + + + M + M + +| 42 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M M + M M + M M M M + M M M M + M M M +| 18 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M M + + + + + + + + + + + + M + + + + + + + + +| 44 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 1 2 | 6 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M + + + + + + + + + + + + + +| 45 |
Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 38 |
Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia | 2 2 2 | 5 2.0|
Infiltration Cellular, Lymphocyte | | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Mineralization | 2 2 1 1 2 2 2 1 2 1 1 2 1| 28 1.5|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 0| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 4| 7| 7| |
DAY ON TEST | 2| 1| 2| 7| 2| 2| 2| 3| 6| 0| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 0| 0| 2| 2| |
| 8| 9| 9| 3| 8| 9| 7| 0| 1| 7| 0| 0| 0| 1| 9| 0| 0| 0| 0| 0| 0| 8| 6| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 8| 9| A |
CONTROL | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 32 1.1|
Inflammation, Chronic | 2| 1 2.0|
Metaplasia, Osseous | 2 2 | 2 2.0|
Polyarteritis | 1 | 1 1.0|
Renal Tubule, Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 | 22 1.1|
Polyarteritis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 2| 3| 2| 3| 0| 3| 2| 2| 2| 2| 2| 2| 2| 3| 7| 2| 3| 2|
| 2| 1| 8| 8| 9| 1| 9| 8| 0| 7| 1| 5| 1| 7| 8| 8| 7| 7| 8| 7| 1| 5| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Infiltration Cellular, Lymphocyte | 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 2 2 |
Eosinophilic Focus | 2 |
Infiltration Cellular, Lymphocyte | 2 1 3 1 1 1 1 1 3|
Inflammation | 1 |
Bile Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 3 1 1 1|
Acinus, Atrophy | 4 |
Acinus, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 2 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 |
Embolus Bacterial | 3 |
Inflammation, Acute | 2 |
Mineralization | |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 2| 3| 2| 3| 0| 3| 2| 2| 2| 2| 2| 2| 2| 3| 7| 2| 3| 2|
| 2| 1| 8| 8| 9| 1| 9| 8| 0| 7| 1| 5| 1| 7| 8| 8| 7| 7| 8| 7| 1| 5| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Amyloid Deposition | 1|
Cyst | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 1 |
Hypertrophy | 2 |
Pigmentation | 1 1|
Vacuolization Cytoplasmic | 1 |
Spindle Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
Cyst | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicular Cell, Hyperplasia | 1 4 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 3 1 3 |
Infiltration Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 1 3 2 2 2 2 1 2 2 2 2 2 3 2 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 1 2 2 2 2 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M M + + + + M M + M M M + M M M M|
Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + M + + M + + + + + + M + + +|
Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 2| 3| 2| 3| 0| 3| 2| 2| 2| 2| 2| 2| 2| 3| 7| 2| 3| 2|
| 2| 1| 8| 8| 9| 1| 9| 8| 0| 7| 1| 5| 1| 7| 8| 8| 7| 7| 8| 7| 1| 5| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + + + M + + M M + + M + M M M + M M M M|
Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 2 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + M + M + M + + + + + + + + + + + + + + + + M +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M + + M M + + + + + + + M M M M + M + + + +|
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Dysplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 2 |
Thalamus, Mineralization | 1 2 2 1 1 2 1 2 1 2 1 2 2|
Ventricle, Dilatation | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Infiltration Cellular, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 2| 3| 2| 3| 0| 3| 2| 2| 2| 2| 2| 2| 2| 3| 7| 2| 3| 2|
| 2| 1| 8| 8| 9| 1| 9| 8| 0| 7| 1| 5| 1| 7| 8| 8| 7| 7| 8| 7| 1| 5| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Infiltration Cellular, Lymphocyte | 2 3 1 2 3 1 1 1 1 1 1 1 1 1 1 2|
Inflammation, Suppurative | 1 |
Renal Tubule, Bacterium | 1 |
Renal Tubule, Casts Protein | 2 1 1 |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Diverticulum | 2| 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 | 1 3.0|
Clear Cell Focus | 1 3 2 | 5 2.0|
Eosinophilic Focus | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 1 1 1 1 1 2 | 18 1.5|
Inflammation | | 1 1.0|
Bile Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1| 24 1.2|
Acinus, Atrophy | 2 | 2 3.0|
Acinus, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 2 2 1 1 1 1 1 1 2 1 2 2 2 1 | 25 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 1 2 | 4 1.5|
Embolus Bacterial | | 1 3.0|
Inflammation, Acute | | 1 2.0|
Mineralization | 2 | 1 2.0|
Polyarteritis | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 3 2 2 2 3 3 2| 49 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 1 1 2 2 | 5 1.4|
Cyst | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 1 | 3 1.0|
Hypertrophy | 2 | 2 2.0|
Pigmentation | 1 1 1 1| 6 1.0|
Vacuolization Cytoplasmic | 3 | 2 2.0|
Spindle Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Angiectasis | 3 1 | 2 2.0|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 2 | 5 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Infiltration Cellular, Lymphocyte | 2 1 1 | 4 1.3|
Follicular Cell, Hyperplasia | 3 1 1 2 1 2 3 | 10 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 1 3 | 10 2.2|
Infiltration Cellular, Lymphocyte | 2 | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 3.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 3 2 1 2 2 2 2| 49 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 1 2 2 1 1 1 1 1 2 2 2 1 3 1 2 1 1 | 33 1.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + + + + M + + + + M M + + M M + + + + +| 32 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + M + M + M M +| 40 |
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + + M M M + + M M M M M M M + M M + M + +| 17 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + M + +| 47 |
Edema | | 1 2.0|
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 3 3 | 3 3.0|
Hyperplasia, Lymphoid | 2 2 1 1 1 2 1 2| 10 1.7|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + M + + + + + + + + + + M + M + + M + + + M +| 40 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + M + + + + + + + M + + M M +| 35 |
Hyperplasia, Cystic | 1 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia | 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sternum, Dysplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 9| 2| 2| 2| 2| 2| 2| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 2| 3| 3| 2| 2| 3| |
| 8| 8| 9| 8| 7| 9| 7| 9| 8| 1| 0| 0| 0| 1| 9| 0| 1| 3| 7| 8| 0| 0| 4| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
10 PPM | 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Inflammation | | 1 2.0|
Thalamus, Mineralization | 1 2 2 1 2 2 1 1 1 1 2 1 2 2 2 2 2| 30 1.6|
Ventricle, Dilatation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Infiltration Cellular, | | |
Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 4 1 1 1 1 3 1 1 2 2 1 2 1 2 2 2| 36 1.5|
Inflammation, Suppurative | | 1 1.0|
Renal Tubule, Bacterium | | 1 1.0|
Renal Tubule, Casts Protein | 1 1 1 1 1 2 | 9 1.2|
Renal Tubule, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 1 1| 22 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | |
Cyst | |
Eosinophilic Focus | 2 |
Infiltration Cellular, Lymphocyte | 3 1 3 |
Inflammation | 2 1 1 |
Mineralization | 2 |
Mixed Cell Focus | |
Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1|
__________________________________________________________________________|
Mesentery | + |
Cyst | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 2 1 |
Acinus, Atrophy | 3 4 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 2 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 1|
Hyperplasia | 2 |
Hypertrophy | |
Pigmentation | 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + + + + + + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + M + + +|
Angiectasis | 2 2 2 |
Hyperplasia | 3 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 1 2 3 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 4 |
Mineralization | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 3 3 1 2 2 2 2 2 2 1 2 3 3 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 2 2 2 2 2 2 1 1 2 1 2 2 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + M + M M + + + M + M + + M + M + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + M M + + M + + + + + + + M M|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M + M + M M M M M + + M + M + M M + + M|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + + + M + + + + + + M + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + + M + M + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Dysplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Thalamus, Mineralization | 2 2 1 1 1 1 2 1 2 1 1 1 1 2 2 1|
Ventricle, Dilatation | 3 |
Ventricle, Mineralization | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 1 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 2 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 1 2 2 1 1 1 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 2| 3| 2| 8| 3| 2| 3| 2| 3| 2| 0| 2| 2| 2| 2| 2| 3| 9| 2| 1| 2|
| 9| 1| 8| 8| 9| 1| 9| 1| 0| 7| 1| 9| 1| 7| 0| 8| 7| 7| 8| 7| 1| 6| 8| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Metaplasia, Osseous | |
Renal Tubule, Casts Protein | 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 | 1 3.0|
Clear Cell Focus | 2 | 1 2.0|
Cyst | 2 | 1 2.0|
Eosinophilic Focus | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 7 1.6|
Inflammation | 1 1 1 | 6 1.2|
Mineralization | | 1 2.0|
Mixed Cell Focus | 2 3 | 2 2.5|
Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Cyst | 3 | 1 3.0|
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 2 1| 17 1.2|
Acinus, Atrophy | 2 3 | 4 3.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 1 1 2| 21 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Dysplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy, Chronic | | 2 1.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spindle Cell, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2 2 3 2 2 2 2| 50 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 1 | 4 1.0|
Hyperplasia | 2 1 | 3 1.7|
Hypertrophy | 2 | 1 2.0|
Pigmentation | 1 1 1| 4 1.0|
Vacuolization Cytoplasmic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + M + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 1 1 1 1| 8 1.6|
Hyperplasia | | 1 3.0|
Pars Distalis, Cyst | 1 | 2 1.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 1 3 1 1 | 6 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 2 2| 10 2.3|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 4.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2| 49 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 2 2 1 2 1 2 2 3 1 2 2 1 2 2 2 1 3 2| 35 1.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + M M + M + + M + M M + + + + + + + + M +| 31 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M M M + M M M M M M M M + M M M M M M + +| 14 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 | 3 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + M + + + M +| 43 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + M M + + + M M + + + M M M + + +| 38 |
Hyperplasia, Cystic | | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia | 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sternum, Dysplasia | 1 2| 2 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Thalamus, Mineralization | 2 1 2 1 2 1 1 1 2 | 25 1.4|
Ventricle, Dilatation | | 1 3.0|
Ventricle, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 4| 2| 2| 3| 3| 3| 2| 3| |
| 8| 7| 9| 8| 7| 9| 7| 9| 9| 1| 0| 0| 0| 1| 9| 0| 1| 0| 7| 8| 0| 0| 0| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
33 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | | 1 1.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | | 2 2.0|
Inflammation, Acute | 2 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 1 | 32 1.3|
Metaplasia, Osseous | 2 | 1 2.0|
Renal Tubule, Casts Protein | 1 1 1 1 | 5 1.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 2 1 1 1 1 2 2 2 1| 25 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 2 2 |
Infiltration Cellular, Lymphocyte | 1 1 3|
Inflammation | |
Mixed Cell Focus | 2 |
Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 |
Acinus, Atrophy | 2 |
Acinus, Inflammation, Chronic Active | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 1 1 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 2 2 1 2 1 1 1 2 1 3 1 1|
Degeneration | 2 2 1 3 3 |
Inflammation, Chronic Active | |
Mineralization | |
Polyarteritis | |
Valve, Cyst | 1 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 3 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cyst | |
Hyperplasia | 2 |
Pigmentation | 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + M|
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
Follicular Cell, Hyperplasia | 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | 2 2 1 2 2 2 1 |
Inflammation | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Atrophy | 3 |
Thrombosis | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 1 3 2 2 2 3 3 2 2 2 2 2 3 2|
Endothelium, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 2 2 2 3 3 2 2 2 2 2 3 2 2 1 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + + M + + + + +|
Pancreatic, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M M M + M I + + M M M + M + + M + M + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + M + + + M + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M + M + M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + M + + + + + + + + + M + + + + +|
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + M + + +|
Atrophy | 2 3 4 4 |
Hyperplasia | |
Necrosis | 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + M + + + + + + M + + + + + + + + +|
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 |
Cyst | |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Dysplasia | 3 2 1 1 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2|
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 |
Cerebellum, Degeneration | 2 3 2 2 2 2 |
Cerebrum, Degeneration | 3 2 |
Thalamus, Mineralization | 1 1 2 1 2 |
Ventricle, Dilatation | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 7| 1| 1| 7| 7| 1| 7| 7| 7| 1| 7| 6| 7| 7| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 8| 3| 3| 3| 4| 2| 2| 3| 3| 2| 2| 3| 3| 5| 2| 3| 4| 3| 2| 3| 2| 3|
| 9| 9| 9| 1| 1| 0| 7| 0| 9| 8| 0| 1| 8| 8| 7| 1| 8| 8| 0| 0| 1| 9| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mineralization | |
Interstitium, Inflammation, Acute, | |
Multifocal | |
Pleura, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Inflammation, Acute | 2 |
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation | 2 |
Olfactory Epithelium, Metaplasia | 1 1 |
Olfactory Epithelium, Necrosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 3|
Metaplasia, Osseous | |
Cortex, Cyst | 1 1 |
Renal Tubule, Casts Protein | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 |
Inflammation | 1 |
Mixed Cell Focus | |
Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1 1|
Acinus, Atrophy | |
Acinus, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 2 1 1 1 1 1 1 1 2 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 1 1 1 1 1 2 1 1 1 2 2 2 2 2|
Degeneration | |
Inflammation, Chronic Active | 1 2 |
Mineralization | |
Polyarteritis | |
Valve, Cyst | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 1 2 3 2 2 3 2 2 2 2 2 2 3 2 3 2 2 2 1 2 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1|
Cyst | 2 |
Hyperplasia | |
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
Follicular Cell, Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 3 2 2 |
Inflammation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 2 |
Atrophy | |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 2 2 2 2 3 2 2 2 3 1 2 2 2 3 2 2 2 2 2|
Endothelium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 2 1 3 2 1 3 1 2 2 2 1 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M M + + M M M M + + M M M + M + + + + M +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + M M M + + + + + M + + + M + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M M M M M M M M M M + M M + M M + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M + + + M + + + + M + + + + + + + M + + + + + + M|
Atrophy | |
Hyperplasia | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + M + M + + + + + + + + M + + + + + + +|
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 2 |
Cyst | 3 |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Dysplasia | 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 1 |
Cerebellum, Degeneration | 2 3 |
Cerebrum, Degeneration | |
Thalamus, Mineralization | 2 2 2 2 2 2 1 2 1 |
Ventricle, Dilatation | 2 1 2|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 5| 7| 7| 7| 7| 4| 2| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 9| 2| 2| 3| 2| 8| 9| 0| 2| 2| 2| 2| 2| 8| 3| 3| 3| 3| 4| 2|
| 8| 7| 8| 8| 7| 8| 8| 8| 1| 7| 5| 5| 1| 8| 8| 9| 7| 9| 8| 1| 0| 0| 0| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
ANIMAL ID | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
100 PPM | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mineralization | 1 |
Interstitium, Inflammation, Acute, | |
Multifocal | 2 |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 1 1 |
Inflammation, Acute | |
Inflammation, Suppurative | |
Nasolacrimal Duct, Inflammation | |
Olfactory Epithelium, Metaplasia | 2 1 1|
Olfactory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 2 1 1 1 1 3 1 1 2 |
Metaplasia, Osseous | 2 |
Cortex, Cyst | 1 |
Renal Tubule, Casts Protein | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | 2 | 5 1.8|
Infiltration Cellular, Lymphocyte | 1 1 | 10 1.2|
Inflammation | | 1 1.0|
Mixed Cell Focus | | 1 2.0|
Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 2 | 16 1.1|
Acinus, Atrophy | 2 | 2 2.0|
Acinus, Inflammation, Chronic Active | | 1 3.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 1 1 | 30 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Dysplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy, Chronic | 1 1 1 | 34 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Degeneration | 2 2 | 7 2.1|
Inflammation, Chronic Active | | 2 1.5|
Mineralization | 2 | 1 2.0|
Polyarteritis | 2 | 1 2.0|
Valve, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + M + | 59 |
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 56 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + M + | 59 |
Amyloid Deposition | 2 2 2 | 4 1.8|
Cyst | | 1 2.0|
Hyperplasia | 1 1 | 3 1.3|
Pigmentation | | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + | 59 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M M + + + M | 55 |
Pars Distalis, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Polyarteritis | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 | 6 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | M + + + + + + + + + | 58 |
Cyst | 2 | 13 1.8|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Adenomyosis | | 1 2.0|
Atrophy | | 1 3.0|
Thrombosis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 1 2 1 | 51 2.0|
Endothelium, Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | 1 2 1 1 2 | 43 1.9|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 57 |
Pancreatic, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M M M M M + | 30 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + M M + + + | 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M + M M M + + | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Angiectasis | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | | 4 2.3|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + + | 51 |
Atrophy | | 4 3.3|
Hyperplasia | | 1 3.0|
Necrosis | | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + | 51 |
Hyperplasia, Cystic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Alopecia | | 5 2.0|
Cyst | 3 2 | 3 2.7|
Infiltration Cellular, Lymphocyte | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Sternum, Dysplasia | 2 | 9 1.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Gliosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | 3 | 3 2.0|
Cerebellum, Degeneration | 1 1 2 | 11 2.0|
Cerebrum, Degeneration | | 2 2.5|
Thalamus, Mineralization | 1 | 15 1.6|
Ventricle, Dilatation | | 3 1.7|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + M + + + + + M | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 2 2.5|
Mineralization | | 1 1.0|
Interstitium, Inflammation, Acute, | | |
Multifocal | | 1 2.0|
Pleura, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Exudate | | 3 1.3|
Inflammation, Acute | | 1 2.0|
Inflammation, Suppurative | 4 | 1 4.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
Olfactory Epithelium, Metaplasia | | 5 1.2|
Olfactory Epithelium, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 34 1.2|
Metaplasia, Osseous | | 1 2.0|
Cortex, Cyst | | 3 1.0|
Renal Tubule, Casts Protein | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 4| 1| 6| 7| 4| 2| | |
DAY ON TEST | 5| 3| 3| 2| 2| 2| 5| 3| 8| 3| | |
| 1| 1| 0| 7| 3| 3| 5| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | 1 1 | 22 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 7| 4| 1| 7| 1| 7| 4| 1| 7| 4| 7| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 6| 6| 2| 7| 2| 5| 7| 2| 5| 2| 2| | |
| 0| 7| 2| 8| 1| 3| 9| 2| 6| 0| 4| 7| 1| 5| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
Spindle Cell, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 7| 4| 1| 7| 1| 7| 4| 1| 7| 4| 7| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 6| 6| 2| 7| 2| 5| 7| 2| 5| 2| 2| | |
| 0| 7| 2| 8| 1| 3| 9| 2| 6| 0| 4| 7| 1| 5| 1| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + M | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 7| 4| 6| 7| 7| 4| 7| 4| 7| 7| 1| 1| 6| | |
DAY ON TEST | 4| 6| 7| 2| 4| 1| 2| 2| 5| 2| 5| 2| 2| 7| 7| 1| | |
| 8| 9| 1| 0| 9| 3| 1| 0| 4| 1| 4| 2| 0| 6| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | A + | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
Spindle Cell, Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | M + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + M | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
Endometrium, Hyperplasia, Cystic | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 7| 4| 6| 7| 7| 4| 7| 4| 7| 7| 1| 1| 6| | |
DAY ON TEST | 4| 6| 7| 2| 4| 1| 2| 2| 5| 2| 5| 2| 2| 7| 7| 1| | |
| 8| 9| 1| 0| 9| 3| 1| 0| 4| 1| 4| 2| 0| 6| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
33 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
Myelofibrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | M + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 1 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + M | 1 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
Adenomatosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
Infiltration Cellular, Lymphocyte | 1 2 | 2 1.5|
Renal Tubule, Casts Protein | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + M | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 1| 1| 0| 7| 7| 0| 1| 4| 7| 1| 4| 7| | |
DAY ON TEST | 4| 2| 4| 2| 4| 4| 9| 2| 2| 8| 4| 5| 2| 4| 5| 2| | |
| 7| 2| 9| 1| 2| 2| 3| 2| 0| 6| 3| 4| 1| 3| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
Degeneration | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
Spindle Cell, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 1| 1| 0| 7| 7| 0| 1| 4| 7| 1| 4| 7| | |
DAY ON TEST | 4| 2| 4| 2| 4| 4| 9| 2| 2| 8| 4| 5| 2| 4| 5| 2| | |
| 7| 2| 9| 1| 2| 2| 3| 2| 0| 6| 3| 4| 1| 3| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | M + | 1 |
Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
Cerebellum, Degeneration | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| | |
| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 5| 5| 4| 5| 5| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 8| 8| | A |
CONTROL | 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + M | 19 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | X X | 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 | 6 1.0|
Inflammation | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Spindle Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 2 1 | 12 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia | 2 1 | 2 1.5|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| | |
| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 5| 5| 4| 5| 5| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 8| 8| | A |
CONTROL | 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + M + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Prostate | + M + + + M + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M + M + M M M + M M M + M M M M M M M + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M + M M M + M M M + M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M M M M + M M M M M M M M M M M + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + M + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M + + M M M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| | |
| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 5| 5| 4| 5| 5| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 8| 8| | A |
CONTROL | 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + M + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Hemorrhage | 1 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Cortex, Infiltration Cellular, | | |
Lymphocyte | 1 1 | 2 1.0|
Cortex, Regeneration | 1 | 1 1.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Medulla, Mineralization | 1 | 1 1.0|
Renal Tubule, Mineralization | 1 1 | 2 1.0|
Renal Tubule, Regeneration | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| | A |
10 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M + | 19 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + | 19 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Acute | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + | 19 |
Hyperplasia, Lymphoid | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Basophilic Focus | X X | 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 | 5 1.0|
Inflammation | 2 | 1 2.0|
Mixed Cell Focus | X | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + | 19 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + | 19 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Spindle Cell, Hyperplasia | 1 1 1 1 1 2 1 | 7 1.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| | A |
10 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + I + + M + M + + + + M + | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 1 | 3 1.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Prostate | M + M + M + + M M + + + + + + M + + + + | 14 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Seminiferous Tubule, Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M + M + + I M M M M M M + + + + M M + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M I M M M M M M + M + + M M M + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + M M M M M M M M + M + M M M M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + | 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M + + M M M + M M M + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 | 6 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| | |
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| | A |
10 PPM | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + M + + + + + + + + + + + + + + + | 19 |
Vacuolization Cytoplasmic | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 2 1 | 2 1.5|
Cortex, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 2 1 1 1 1 1 2 2 1 1 | 10 1.3|
Medulla, Mineralization | 1 | 1 1.0|
Renal Tubule, Casts Protein | 1 | 1 1.0|
Renal Tubule, Degeneration | 1 | 1 1.0|
Renal Tubule, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 0| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Gallbladder | + M A M + M + M + + M + + + + + M + + M | 12 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + | 19 |
Hyperplasia, Glandular | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + | 19 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 20 |
Hematopoietic Cell Proliferation | 1 1 1 | 3 1.0|
Necrosis | 3 | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 2 2 | 5 1.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 | 3 1.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Spindle Cell, Hyperplasia | 1 1 1 1 1 1 2 | 7 1.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 20 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + M + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 0| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + M M + M + + + + + + + | 16 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 20 |
Cyst | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + M + + M + + + + + + + + + M + + | 17 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 20 |
Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node | M + + + + M + + M M M M + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M M M M M M M M + + M + M + M + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + M + + M M M M M + + M + M + M | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 20 |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + M + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M M M + M M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 20 |
Sternum, Dysplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 8| 8| 0| 8| 8| 8| 8| 8| 8| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 3| 3| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 4| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| | L |
INTERIM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 20 |
Vacuolization Cytoplasmic | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
Inflammation, Chronic | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 20 |
Cortex, Cyst | 1 | 1 1.0|
Cortex, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
Cortex, Regeneration | 1 1 | 2 1.0|
Interstitium, Infiltration Cellular, | | |
Lymphocyte | 1 1 1 1 1 1 1 | 7 1.0|
Medulla, Mineralization | 1 | 1 1.0|
Renal Tubule, Regeneration | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 20 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 2| 2| 3| 2| 2| 9| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 3| 2| 3| 9|
| 9| 0| 0| 0| 8| 8| 0| 9| 7| 2| 8| 9| 9| 7| 0| 0| 8| 7| 7| 0| 8| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 2 2 |
Cyst | |
Eosinophilic Focus | X 2 2 |
Infiltration Cellular, Lymphocyte | 1 3 |
Inflammation | 1 1 2 |
Mixed Cell Focus | X 3 2 2 |
Necrosis | |
Bile Duct, Proliferation | |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Infiltration Cellular, Lymphocyte | 1 1 2 |
Inflammation, Chronic | |
Polyarteritis | 2 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 1 2 1 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Chronic | 2 |
Metaplasia | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 2| 2| 3| 2| 2| 9| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 3| 2| 3| 9|
| 9| 0| 0| 0| 8| 8| 0| 9| 7| 2| 8| 9| 9| 7| 0| 0| 8| 7| 7| 0| 8| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 2 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 3 1 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 2 3 2 2 2 3 |
Hypertrophy | 2 2 2 2 |
Pigmentation | 1 |
Vacuolization Cytoplasmic | 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + M + + M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + M M + + + + + M + + + + + M + +|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + M + + + + |
Cyst | 3 3 3 3 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + M + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Polyarteritis | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 2| 2| 3| 2| 2| 9| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 3| 2| 3| 9|
| 9| 0| 0| 0| 8| 8| 0| 9| 7| 2| 8| 9| 9| 7| 0| 0| 8| 7| 7| 0| 8| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + M + + + + M + + + + + + M + M + + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M + + + + + M M M M M M M M + M M + M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + M + + + + M + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + M + + + + + M + + + +|
Atrophy | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic Active | 3 3 |
Prepuce, Inflammation, Chronic Active| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Thalamus, Mineralization | 2 3 3 2 3 2 1 2 3 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 3| 2| 2| 3| 2| 2| 9| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 2| 3| 2| 3| 9|
| 9| 0| 0| 0| 8| 8| 0| 9| 7| 2| 8| 9| 9| 7| 0| 0| 8| 7| 7| 0| 8| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 |
Inflammation, Chronic | 1 1 1 1 1 2 3 3 2 2 1 1 1 |
Cortex, Cyst | 2 2|
Renal Tubule, Casts Protein | 2 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Mineralization | 1 1 1 1 2 1 1 1 2 1 1 1 1 2 1 1 1 1 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 2 |
__________________________________________________________________________|
Urethra | + |
Foreign Body | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Chronic | 3 2 |
Polyarteritis | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 0| 8| 2| 5| 3| 2| 2| 1| 2| 3| 2| 0| 3| 2| 3| 3| 0| 2| 2| 2| 3| 2| |
| 1| 8| 7| 3| 4| 9| 3| 1| 7| 7| 6| 9| 1| 3| 2| 0| 8| 0| 1| 2| 9| 7| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + M + + + + A A + + + + + + + M + +| 44 |
Hyperplasia, Focal | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Diverticulum | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + A + + + M + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + A A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + A A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + M A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 2 1.5|
Clear Cell Focus | 2 2 | 4 2.0|
Cyst | 1 | 1 1.0|
Eosinophilic Focus | 2 2 | 5 2.0|
Infiltration Cellular, Lymphocyte | | 2 2.0|
Inflammation | 2 2 2 2 1 3 1 | 10 1.7|
Mixed Cell Focus | X 3 2 | 7 2.4|
Necrosis | 2 | 1 2.0|
Bile Duct, Proliferation | 1 | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 1 | 7 1.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 2 | 7 1.3|
Inflammation, Chronic | 2 | 1 2.0|
Polyarteritis | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 2 2 1 2 2 2 1 1 1 2 2 1 1| 25 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
Infiltration Cellular, Lymphocyte | | 2 1.5|
Inflammation, Chronic | 3 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 0| 8| 2| 5| 3| 2| 2| 1| 2| 3| 2| 0| 3| 2| 3| 3| 0| 2| 2| 2| 3| 2| |
| 1| 8| 7| 3| 4| 9| 3| 1| 7| 7| 6| 9| 1| 3| 2| 0| 8| 0| 1| 2| 9| 7| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Metaplasia | 1 | 2 1.5|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Dysplasia | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 2 | 4 1.5|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Spindle Cell, Hyperplasia | 2 1 3 2 1 2 2 2 2 2 2 2 3 2 2 2 2 3 2 | 41 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Cyst | | 1 2.0|
Hyperplasia | 1 2 3 2 | 10 2.2|
Hypertrophy | 2 1 1 1 1 1 2 2 | 12 1.6|
Pigmentation | 2 | 2 1.5|
Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 | 15 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 2 2 3 | 8 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + M + + + M + + M M + + M + + + + + + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + M + + +| 43 |
Cyst | 1 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 | 2 1.5|
Follicular Cell, Hyperplasia | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 6 |
Cyst | 3 | 6 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 0| 8| 2| 5| 3| 2| 2| 1| 2| 3| 2| 0| 3| 2| 3| 3| 0| 2| 2| 2| 3| 2| |
| 1| 8| 7| 3| 4| 9| 3| 1| 7| 7| 6| 9| 1| 3| 2| 0| 8| 0| 1| 2| 9| 7| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + M + + + + + + + + + + + + + M + + + + M + + + +| 45 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Inflammation, Chronic Active | 3 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 4 | 1 4.0|
Polyarteritis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M + + M M M M + + M M M M + + M + M + + M| 27 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + M + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + M M M M M M M + M + M M + + M + + M M +| 22 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M M M + + + + + + + + +| 44 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + M M + + + + + M M + + + + + + + +| 41 |
Atrophy | 3 | 1 3.0|
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + M M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
Prepuce, Inflammation, Chronic Active| 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 2| 0| 8| 2| 5| 3| 2| 2| 1| 2| 3| 2| 0| 3| 2| 3| 3| 0| 2| 2| 2| 3| 2| |
| 1| 8| 7| 3| 4| 9| 3| 1| 7| 7| 6| 9| 1| 3| 2| 0| 8| 0| 1| 2| 9| 7| 9| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Thalamus, Mineralization | 2 1 2 3 2 2 3 1 2 1 3 2 1 2 1 2| 28 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + M + + + + + + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | | 1 2.0|
Infiltration Cellular, Histiocyte | 3 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 1 1.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 2 | 3 2.0|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 2 1 2 2 1 2 1 1 2 | 19 1.6|
Inflammation, Chronic | 2 1 1 2 2 1 1 | 20 1.5|
Cortex, Cyst | 2 1 2 2 2 | 7 1.9|
Renal Tubule, Casts Protein | 3 2 | 3 2.3|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Mineralization | 1 1 1 1 3 1 1 1 1 3 2 1 1 1 2 1 2 1 1| 38 1.3|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Urethra | | 1 |
Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 2 4 1 1 | 7 1.9|
Inflammation, Chronic | | 2 2.5|
Polyarteritis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 1| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 3|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 7| 2| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 3| 4| 9| 2| 5|
| 1| 0| 0| 5| 8| 8| 0| 8| 9| 8| 9| 9| 7| 9| 0| 8| 7| 9| 2| 8| 0| 2| 5| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + M + + + A + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 3 1 2 |
Congestion | 2|
Eosinophilic Focus | 3 X |
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 |
Mineralization | |
Mixed Cell Focus | 2 2 2 2 |
Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 3 2 1 2 2|
__________________________________________________________________________|
Mesentery | + +|
Fat, Necrosis | 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 |
Acinus, Cyst | 2 |
Acinus, Hyperplasia | 2 |
Fat, Necrosis | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
Hyperplasia | |
Inflammation, Chronic | |
Metaplasia | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 1| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 3|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 7| 2| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 3| 4| 9| 2| 5|
| 1| 0| 0| 5| 8| 8| 0| 8| 9| 8| 9| 9| 7| 9| 0| 8| 7| 9| 2| 8| 0| 2| 5| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 1 |
Necrosis, Acute | 2 |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Spindle Cell, Hyperplasia | 1 2 2 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 |
Hypertrophy | 1 1 |
Pigmentation | |
Vacuolization Cytoplasmic | 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 1 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + M + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + M +|
Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Chronic Active | |
Mineralization | 2 |
__________________________________________________________________________|
Preputial Gland | + + |
Cyst | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 1| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 3|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 7| 2| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 3| 4| 9| 2| 5|
| 1| 0| 0| 5| 8| 8| 0| 8| 9| 8| 9| 9| 7| 9| 0| 8| 7| 9| 2| 8| 0| 2| 5| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + M + M + M M M + + M M M M M M + M M M M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + + + + + M + + M + + + + + + + M + M M|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M M M M M M M M M M M M M + M + M + M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 3 2 1 2 2 2 1 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M M + + + M + + + + + M M + + + + M|
Atrophy | 4 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Alopecia | 2 |
Cyst | 2 3 |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 2 2 2 1 2 2 2 2 2 2 2 2 2 |
Ventricle, Dilatation | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sciatic, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Lung | + M + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 3 3 3 3 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 1| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 3|
DAY ON TEST | 3| 2| 3| 2| 2| 2| 3| 2| 7| 2| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 3| 4| 9| 2| 5|
| 1| 0| 0| 5| 8| 8| 0| 8| 9| 8| 9| 9| 7| 9| 0| 8| 7| 9| 2| 8| 0| 2| 5| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 2 1 2 |
Inflammation, Chronic | 2 2 |
Cortex, Cyst | 2 |
Renal Tubule, Casts Protein | 2 1 1 2 |
Renal Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + + + + + + + M + + + + + + A + + + + | 43 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Basophilic Focus | | 1 2.0|
Clear Cell Focus | 2 3 | 5 2.2|
Congestion | | 1 2.0|
Eosinophilic Focus | | 2 3.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation | | 1 2.0|
Mineralization | 3 | 1 3.0|
Mixed Cell Focus | 3 | 5 2.2|
Necrosis | 2 | 2 1.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 | 8 1.8|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 3 1.0|
Acinus, Atrophy | | 1 2.0|
Acinus, Cyst | | 1 2.0|
Acinus, Hyperplasia | | 1 2.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 2 2 1 1 3 1 | 23 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | | 2 1.5|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Metaplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Cardiomyopathy, Chronic | 1 1 1 1 2 1 | 7 1.1|
Inflammation, Chronic Active | | 2 2.0|
Necrosis, Acute | | 1 2.0|
Polyarteritis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + M + + + + + + | 47 |
Spindle Cell, Hyperplasia | 2 2 2 2 1 2 2 2 1 2 2 2 2 3 3 2 2 1 2 | 31 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + M + + + + + + | 47 |
Hyperplasia | 2 | 2 1.5|
Hypertrophy | 1 | 3 1.0|
Pigmentation | 2 1 | 2 1.5|
Vacuolization Cytoplasmic | 1 2 2 1 | 11 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + | 47 |
Hyperplasia | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia | 1 2 2 1 3 | 10 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + | 46 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + M + M + + + + + + | 44 |
Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | | 2 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | | 1 2.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M + M M + M M M M + + M + + M M M M M M | 14 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + | 41 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M + M + + M M + M + M M M M M M M M M | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 1 1 2 1 | 12 1.7|
Hyperplasia, Lymphoid | 1 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + M + + M M + + + + + + M + + + + M + + | 36 |
Atrophy | | 1 4.0|
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M + M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Abscess | | 1 2.0|
Alopecia | 2 | 2 2.0|
Cyst | 3 2 | 4 2.5|
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Thalamus, Mineralization | 2 2 2 1 1 1 2 1 2 2 2 1 | 25 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 2| 2| 4| 6| 3| 3| 2| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 0| 2| 2| 1| 2| | |
| 8| 7| 7| 6| 6| 1| 1| 7| 7| 1| 9| 1| 1| 9| 0| 8| 0| 1| 8| 4| 7| 9| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| | A |
10 PPM | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Ventricle, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Sciatic, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Inflammation, Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenomatosis | 1 | 1 1.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 6 2.5|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Inflammation, Acute | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infarct | 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 2 1 | 16 1.4|
Inflammation, Chronic | 1 2 2 2 | 6 1.8|
Cortex, Cyst | | 1 2.0|
Renal Tubule, Casts Protein | 1 2 | 6 1.5|
Renal Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 30 1.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + M M + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Clear Cell Focus | 2 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | 1 3 |
Mixed Cell Focus | 3 |
Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 3 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 |
Acinus, Atrophy | |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 2 2 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 1 |
Embolus Bacterial | |
Inflammation, Acute | |
Polyarteritis | 2 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 1 3 2 3 2 2 4 2 1 2 2 2 3 4 1 2 4 4 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 3 |
Hypertrophy | 2 2 2 2 |
Necrosis | |
Pigmentation | 2 2 |
Vacuolization Cytoplasmic | 1 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 4 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Polyarteritis | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Cyst | 2 3 3 |
Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M + M M M M + M + M + + M M + M + + M M M M +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + + + + + + M + M + + + + + M + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M M + M M + M M M M M M M M + M M + M M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + M + + + + + + + + + M M +|
Angiectasis | |
Edema | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Re Cell | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M + + + + M + + + + + + M|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Alopecia | |
Cyst | 2 3 |
Inflammation, Chronic Active | 2 |
Prepuce, Inflammation, Chronic Active| 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 2 |
Thalamus, Mineralization | 1 1 2 2 2 2 1 2 1 1 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 2| 9| 8| 9| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 3| 6| 6| 2| 3| 2|
| 9| 0| 0| 0| 0| 7| 1| 0| 7| 9| 8| 9| 9| 7| 9| 0| 8| 7| 7| 0| 4| 1| 7| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 1|
Inflammation, Suppurative | 1 |
Olfactory Epithelium, Metaplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 3 1 1 1 2|
Inflammation, Chronic | 2 2 2 1 1 3 2 |
Cortex, Cyst | 1 1 1|
Renal Tubule, Casts Protein | 3 |
Renal Tubule, Mineralization | 1 1 2 1 2 1 1 1 2 1 2 1 1 1 2 1 1|
Renal Tubule, Pigmentation | 3 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 1 |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
Polyarteritis | 1 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + + + + + + + + + M + + + + + +| 45 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 3.0|
Clear Cell Focus | 2 2 2 2 3 2 | 8 2.1|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | 2 | 3 2.0|
Mixed Cell Focus | | 1 3.0|
Necrosis | 4 3 3 | 3 3.3|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 1 | 7 1.6|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 | 8 1.3|
Acinus, Atrophy | 2 2 | 2 2.0|
Acinus, Hyperplasia | 1| 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 2 2 1 2 1 2 1 | 24 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hyperplasia | 2 2 2 | 3 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + | 4 |
Dysplasia | 3 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Chronic | 1 2 1 1 2 1 | 10 1.2|
Embolus Bacterial | 3 | 1 3.0|
Inflammation, Acute | 3 | 1 3.0|
Polyarteritis | | 1 2.0|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spindle Cell, Hyperplasia | 2 3 2 1 2 1 2 1 2 2 2 1 1 2 1 1 1 1 1| 38 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Hyperplasia | 1 | 3 2.0|
Hypertrophy | 1 | 5 1.8|
Necrosis | 4 | 1 4.0|
Pigmentation | 1| 3 1.7|
Vacuolization Cytoplasmic | 2 2 2 1 1 2 1| 12 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 3 1 1 1 2 2 | 17 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + M + + + + + M + + + + + +| 46 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 9 |
Cyst | 2 3 2 3 3 | 8 2.6|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + M + + + + + + M M M + + + + + + + + +| 45 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | 1 | 1 1.0|
Mineralization | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Re Cell | | 1 2.0|
Myelofibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M M + + M + + + + M M + + M M M + M M M +| 21 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + M + +| 43 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M M M M M + M M + M M + M M M M M M| 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + M M M + M +| 41 |
Angiectasis | 2 | 1 2.0|
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 4 2 3 2 2 | 9 2.2|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + M + + + + M + M + M + + + +| 41 |
Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3| 1 3.0|
Alopecia | 2 | 1 2.0|
Cyst | 2 | 3 2.3|
Inflammation, Chronic Active | | 1 2.0|
Prepuce, Inflammation, Chronic Active| | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sternum, Dysplasia | 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| |
DAY ON TEST | 3| 2| 2| 2| 2| 2| 3| 3| 2| 2| 3| 6| 0| 3| 2| 3| 2| 3| 3| 2| 1| 2| 7| 3| 2| |
| 0| 8| 7| 8| 7| 9| 1| 1| 7| 7| 1| 9| 6| 1| 9| 0| 8| 0| 1| 8| 2| 7| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
33 PPM | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyarteritis | | 1 2.0|
Thalamus, Mineralization | 2 2 1 2 1 1 1 1 3 1 3 1 2 1 | 25 1.6|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1| 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenomatosis | 2 | 2 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 | 3 1.7|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 1 1 | 5 1.2|
Inflammation, Suppurative | | 1 1.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 2 1 2 2 | 18 1.4|
Inflammation, Chronic | 2 2 3 2 3 2 4 2 2 | 16 2.2|
Cortex, Cyst | 1 2 | 5 1.2|
Renal Tubule, Casts Protein | 3 2 4 3 2 | 6 2.8|
Renal Tubule, Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2| 32 1.3|
Renal Tubule, Pigmentation | | 1 3.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Infiltration Cellular, Lymphocyte | | 4 1.0|
Polyarteritis | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 5| 1| 1| 1| 1| 1| 7| 4| 3| 0| 7| 7| 7| 1| 7| 6| 7| 5| 1| 4| 7| 5| 7| 4| 0|
DAY ON TEST | 4| 3| 3| 3| 2| 3| 2| 9| 8| 8| 3| 3| 3| 3| 2| 8| 2| 9| 7| 8| 2| 5| 3| 1| 8|
| 2| 7| 8| 7| 3| 1| 8| 6| 7| 7| 0| 1| 1| 7| 2| 7| 9| 6| 7| 5| 9| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + A + + M + + + + + + + + + A A + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + M + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + A + + + + + + + + + A A + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + M + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | 3 |
Infiltration Cellular, Lymphocyte | 2 1 |
Inflammation | |
Mineralization | |
Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 1 2 |
Kupffer Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 |
Acinus, Degeneration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Metaplasia | |
Mineralization | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 2 2 2 3 2 2 3 1 |
Degeneration | 2 2 2 1 2 2 1 1|
Inflammation, Acute | 2 |
Mineralization | |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 5| 1| 1| 1| 1| 1| 7| 4| 3| 0| 7| 7| 7| 1| 7| 6| 7| 5| 1| 4| 7| 5| 7| 4| 0|
DAY ON TEST | 4| 3| 3| 3| 2| 3| 2| 9| 8| 8| 3| 3| 3| 3| 2| 8| 2| 9| 7| 8| 2| 5| 3| 1| 8|
| 2| 7| 8| 7| 3| 1| 8| 6| 7| 7| 0| 1| 1| 7| 2| 7| 9| 6| 7| 5| 9| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 2 1 2 2 2 1 2 3 2 2 2 2 1 2 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Hypertrophy | 2 2 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + M + + + + + M + M + M + + + + M M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + M + + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
__________________________________________________________________________|
Preputial Gland | |
Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + M + M + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 1 3 1 1 2 1|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + I + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | M + + + + M + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + M M M M M M M M + + + M M M M M M M M M|
__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M M M + + + M M + + M M + + M + + M|
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M M + M M M M M M M M M M M + M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + M + + + + + + + + + M + + M M + + + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 4 |
Degeneration | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | M + M + M + + + M M M + + + + + M + M M + + + M M|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 5| 1| 1| 1| 1| 1| 7| 4| 3| 0| 7| 7| 7| 1| 7| 6| 7| 5| 1| 4| 7| 5| 7| 4| 0|
DAY ON TEST | 4| 3| 3| 3| 2| 3| 2| 9| 8| 8| 3| 3| 3| 3| 2| 8| 2| 9| 7| 8| 2| 5| 3| 1| 8|
| 2| 7| 8| 7| 3| 1| 8| 6| 7| 7| 0| 1| 1| 7| 2| 7| 9| 6| 7| 5| 9| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 2 2 3 |
Necrosis | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Dysplasia | 3 3 3 2 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Degeneration | 2 2 2 3 1 2 3 2 1|
Cerebrum, Degeneration | 1 |
Thalamus, Mineralization | 2 1 1 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | 2 |
Hemorrhage | 2 |
Pigmentation | 2 |
Mediastinum, Inflammation, Acute | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 |
Inflammation, Suppurative | |
Olfactory Epithelium, Metaplasia | 1 |
Olfactory Epithelium, Necrosis | 2 |
Respiratory Epithelium, Metaplasia | |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 1 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 5| 1| 1| 1| 1| 1| 7| 4| 3| 0| 7| 7| 7| 1| 7| 6| 7| 5| 1| 4| 7| 5| 7| 4| 0|
DAY ON TEST | 4| 3| 3| 3| 2| 3| 2| 9| 8| 8| 3| 3| 3| 3| 2| 8| 2| 9| 7| 8| 2| 5| 3| 1| 8|
| 2| 7| 8| 7| 3| 1| 8| 6| 7| 7| 0| 1| 1| 7| 2| 7| 9| 6| 7| 5| 9| 8| 0| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 2 1 1 |
Inflammation, Chronic | 1 2 |
Cortex, Cyst | 1 |
Renal Tubule, Casts Protein | 1 2 1 |
Renal Tubule, Mineralization | 1 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 0| 0| 0| 7| 5| 0| 1| 5| 1| 7| 5| 1| 1| 2| 1| 5| 7| 6| 7| 4| 7| 1| 1| 0| 1|
DAY ON TEST | 8| 6| 0| 2| 6| 8| 3| 4| 3| 1| 4| 3| 3| 4| 3| 0| 3| 4| 3| 8| 3| 2| 2| 8| 3|
| 8| 7| 3| 7| 3| 1| 7| 5| 7| 4| 7| 7| 8| 3| 2| 3| 0| 7| 1| 2| 1| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + M + + M|
__________________________________________________________________________|
Gallbladder | + + A + + A + M M + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + A A + + + + M + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + A A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 |
Mineralization | 2 |
Necrosis | 1 3 3 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 1 1 2 2|
Kupffer Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 |
Acinus, Degeneration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Stomach | + + M + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + A + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Metaplasia | |
Mineralization | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 3 |
Degeneration | 1 2 1 2 1 2 1 1 2 1 2 1 3|
Inflammation, Acute | |
Mineralization | 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 0| 0| 0| 7| 5| 0| 1| 5| 1| 7| 5| 1| 1| 2| 1| 5| 7| 6| 7| 4| 7| 1| 1| 0| 1|
DAY ON TEST | 8| 6| 0| 2| 6| 8| 3| 4| 3| 1| 4| 3| 3| 4| 3| 0| 3| 4| 3| 8| 3| 2| 2| 8| 3|
| 8| 7| 3| 7| 3| 1| 7| 5| 7| 4| 7| 7| 8| 3| 2| 3| 0| 7| 1| 2| 1| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Spindle Cell, Hyperplasia | 1 2 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + M + + M + M + M + + + M + M + M M|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + M I + M M + + + M + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + M + + + + M|
Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + M + + + + + + + + + +|
Degeneration | 1 |
__________________________________________________________________________|
Preputial Gland | |
Cyst | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 1 2 1 1 2 2 1 1 1 1 1|
Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + I + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + M + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | I + M + M + M M + M M M + M M M M M + M + M I + M|
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M M M M + + M M M M + M + M + + + M M M +|
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M M M + + + M + + M + M M + + M + + M M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 1|
Degeneration | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | M M + M + M + + + + M + + M + + + M M M + + + M +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 0| 0| 0| 7| 5| 0| 1| 5| 1| 7| 5| 1| 1| 2| 1| 5| 7| 6| 7| 4| 7| 1| 1| 0| 1|
DAY ON TEST | 8| 6| 0| 2| 6| 8| 3| 4| 3| 1| 4| 3| 3| 4| 3| 0| 3| 4| 3| 8| 3| 2| 2| 8| 3|
| 8| 7| 3| 7| 3| 1| 7| 5| 7| 4| 7| 7| 8| 3| 2| 3| 0| 7| 1| 2| 1| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 4 3 3 3 4 3|
Necrosis | 2 3 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + I + +|
Sternum, Dysplasia | 3 1 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Degeneration | 1 1 1 3 2 3 1 2 1 3 1 3|
Cerebrum, Degeneration | 1 1 1 1 1 1 1 |
Thalamus, Mineralization | 2 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + M + + + I + + M M + + + M + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomatosis | |
Hemorrhage | |
Pigmentation | |
Mediastinum, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Inflammation, Suppurative | 1 2 |
Olfactory Epithelium, Metaplasia | 1 |
Olfactory Epithelium, Necrosis | 3 1 2 2 2 |
Respiratory Epithelium, Metaplasia | 1 |
Respiratory Epithelium, Necrosis | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
_____________________________________________________________________________________________________________________
| 0| 0| 0| 7| 5| 0| 1| 5| 1| 7| 5| 1| 1| 2| 1| 5| 7| 6| 7| 4| 7| 1| 1| 0| 1|
DAY ON TEST | 8| 6| 0| 2| 6| 8| 3| 4| 3| 1| 4| 3| 3| 4| 3| 0| 3| 4| 3| 8| 3| 2| 2| 8| 3|
| 8| 7| 3| 7| 3| 1| 7| 5| 7| 4| 7| 7| 8| 3| 2| 3| 0| 7| 1| 2| 1| 3| 3| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|
100 PPM | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Chronic | |
Cortex, Cyst | 2 |
Renal Tubule, Casts Protein | 2 |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 1| 7| 3| 0| 0| 0| 0| 3| 1| 1| 7| 1| 1| 2| 1| 1| 7| | |
DAY ON TEST | 2| 1| 3| 3| 2| 8| 7| 8| 8| 8| 6| 3| 3| 3| 3| 3| 8| 3| 8| 2| | |
| 9| 8| 1| 0| 7| 8| 5| 8| 0| 2| 8| 7| 1| 1| 7| 1| 7| 7| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + + + + + + + + + + + | 64 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + A + + A + + A + + A + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + A + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + A + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + A + + + + + + + | 61 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + A + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Basophilic Focus | 3 1 | 2 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 2 1.5|
Inflammation | 3 | 2 2.5|
Mineralization | | 1 2.0|
Necrosis | | 4 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 1 | 18 1.4|
Kupffer Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
Acinus, Atrophy | 1 | 3 1.7|
Acinus, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + | 68 |
Infiltration Cellular, Lymphocyte | 1 | 6 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 |
Inflammation, Chronic | 3 | 2 2.0|
Metaplasia | 2 | 1 2.0|
Mineralization | | 1 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy, Chronic | 3 1 1 1 2 1 1 2 | 24 1.9|
Degeneration | 1 2 2 1 3 2 2 2 1 2 1 | 32 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 1| 7| 3| 0| 0| 0| 0| 3| 1| 1| 7| 1| 1| 2| 1| 1| 7| | |
DAY ON TEST | 2| 1| 3| 3| 2| 8| 7| 8| 8| 8| 6| 3| 3| 3| 3| 3| 8| 3| 8| 2| | |
| 9| 8| 1| 0| 7| 8| 5| 8| 0| 2| 8| 7| 1| 1| 7| 1| 7| 7| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation, Acute | 1 | 2 1.5|
Mineralization | 2 | 2 1.5|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
Spindle Cell, Hyperplasia | 2 2 1 1 2 1 1 2 1 | 33 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia | | 2 1.5|
Hypertrophy | | 3 1.7|
Vacuolization Cytoplasmic | 3 1 | 4 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + M M M + M M + + + + + + + + + | 45 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + M M M M + + + I + + + + I M + | 51 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + M + + + + + + + + + + + + | 65 |
Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 69 |
Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
Cyst | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + M + + + + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration | 1 1 1 1 1 1 1 1 | 28 1.2|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + I + + + + + I + + | 65 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + M M + + + + M M + M + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 1| 7| 3| 0| 0| 0| 0| 3| 1| 1| 7| 1| 1| 2| 1| 1| 7| | |
DAY ON TEST | 2| 1| 3| 3| 2| 8| 7| 8| 8| 8| 6| 3| 3| 3| 3| 3| 8| 3| 8| 2| | |
| 9| 8| 1| 0| 7| 8| 5| 8| 0| 2| 8| 7| 1| 1| 7| 1| 7| 7| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M M M I + + M M M M M + M M M M + | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M M M M M M + M + M M M M M + | 27 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M M M M M M M M M M M M M M M M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + M + + + M M + + M + M M + M + | 46 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | 1 3 1 1 | 10 2.0|
Degeneration | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + M M M M M + + + + + + + + M | 42 |
Atrophy | 2 1 | 11 2.7|
Necrosis | 3 2 1 | 9 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M + M M M M + M + M M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Alopecia | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 69 |
Sternum, Dysplasia | 2 3 3 2 | 14 2.6|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Cerebellum, Degeneration | 3 2 1 3 2 3 1 2 1 1 | 31 1.9|
Cerebrum, Degeneration | 1 2 1 | 11 1.1|
Thalamus, Mineralization | 3 2 1 1 2 1 1 | 15 1.6|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + M + + M + + I + + + M + | 66 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + M + I + + + M + + + + I + + I + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Adenomatosis | | 1 2.0|
Hemorrhage | 1 | 2 1.5|
Pigmentation | | 1 2.0|
Mediastinum, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 1| 7| 3| 0| 0| 0| 0| 3| 1| 1| 7| 1| 1| 2| 1| 1| 7| | |
DAY ON TEST | 2| 1| 3| 3| 2| 8| 7| 8| 8| 8| 6| 3| 3| 3| 3| 3| 8| 3| 8| 2| | |
| 9| 8| 1| 0| 7| 8| 5| 8| 0| 2| 8| 7| 1| 1| 7| 1| 7| 7| 4| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | L |
TERMINAL | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + I + + + + + + + + + + + + + | 69 |
Inflammation, Acute | 1 1 | 8 1.0|
Inflammation, Suppurative | | 2 1.5|
Olfactory Epithelium, Metaplasia | | 2 1.0|
Olfactory Epithelium, Necrosis | | 6 2.0|
Respiratory Epithelium, Metaplasia | | 1 1.0|
Respiratory Epithelium, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + I + + + + + + + + + + + + | 67 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Infarct | | 2 1.5|
Infiltration Cellular, Lymphocyte | 2 1 | 8 1.3|
Inflammation, Chronic | 1 | 3 1.3|
Cortex, Cyst | | 2 1.5|
Renal Tubule, Casts Protein | 1 | 5 1.4|
Renal Tubule, Mineralization | 1 2 2 | 6 1.3|
Renal Tubule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + | 68 |
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 4| 7| 1| 4| 1| 7| 6| 4| 1| 5| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 4| 2| 7| 5| 7| 2| 2| 5| 7| 4| 2| | |
| 0| 7| 0| 0| 0| 8| 0| 1| 4| 7| 2| 9| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
Basophilic Focus | 2 | 1 2.0|
Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
Cardiomyopathy, Chronic | 2 | 1 2.0|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 2 |
Spindle Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | M + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 4| 7| 1| 4| 1| 7| 6| 4| 1| 5| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 4| 2| 7| 5| 7| 2| 2| 5| 7| 4| 2| | |
| 0| 7| 0| 0| 0| 8| 0| 1| 4| 7| 2| 9| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
Polyarteritis | 2 | 1 2.0|
Thalamus, Mineralization | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M + | 1 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | M + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 7| 7| 4| 7| 1| 4| 1| 7| 6| 4| 1| 5| 7| | |
DAY ON TEST | 7| 4| 2| 2| 2| 4| 2| 7| 5| 7| 2| 2| 5| 7| 4| 2| | |
| 0| 7| 0| 0| 0| 8| 0| 1| 4| 7| 2| 9| 5| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
33 PPM | 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
Polyarteritis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| 3| 0| 4| 1| 1| 1| | |
DAY ON TEST | 3| 4| 8| 4| 3| 3| 3| 4| 7| 4| 5| 8| 1| 4| 3| 2| | |
| 0| 2| 0| 2| 1| 0| 7| 0| 5| 3| 4| 0| 8| 3| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 12 |
Necrosis | 2 | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 12 |
Acinus, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 12 |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 12 |
Cardiomyopathy, Chronic | 1 | 1 1.0|
Degeneration | 2 3 2 2 2 2 1 1 3 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 12 |
Spindle Cell, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + M M + M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + I M + + M I + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05101-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC METHYL BROMIDE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:58:07
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 0| 1| 3| 0| 4| 1| 1| 1| | |
DAY ON TEST | 3| 4| 8| 4| 3| 3| 3| 4| 7| 4| 5| 8| 1| 4| 3| 2| | |
| 0| 2| 0| 2| 1| 0| 7| 0| 5| 3| 4| 0| 8| 3| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | T |
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A |
100 PPM | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | L |
NEURO | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 12 |
Degeneration | 1 1 1 1 2 2 1 1 1 1 | 10 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + I + + I + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + M M + + M + M + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M M + M M + M I M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M + M M + M M M | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M + M M M M M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M M + M M + M + + | 7 |
__________________________________________________________________________|____________|
Spleen | M + + + + + + + + + + + | 11 |
Atrophy | 1 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Thymus | M M + + + + M M M M + + | 6 |
Atrophy | 2 4 4 2 | 4 3.0|
Necrosis | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | +