TDMS Study 05132-06 Pathology Tables
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
Facility: Battelle Northwest
Chemical CAS #: 116-14-3
Lock Date: 10/14/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 58 58 58 58
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 4 16 15 17
Moribund Sacrifice 8 28 26 27
Accidently Killed 1
Survivors
Terminal Sacrifice 36 4 6 4
Animals Examined Microscopically 58 58 58 58
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (51) (46) (44) (44)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Colon (57) (55) (52) (50)
Infarct 1 (2%)
Mesothelium, Inflammation, Chronic Active 2 (4%)
Intestine Large, Rectum (58) (58) (52) (51)
Mesothelium, Inflammation, Chronic Active 1 (2%)
Intestine Large, Cecum (57) (52) (50) (46)
Developmental Malformation 1 (2%)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%)
Mesothelium, Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (55) (49) (49) (45)
Mesothelium, Inflammation, Chronic Active 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Intestine Small, Jejunum (56) (47) (49) (45)
Hemorrhage 1 (2%)
Perforation 1 (2%)
Mesothelium, Inflammation, Chronic Active 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (56) (49) (49) (45)
Mesothelium, Inflammation, Chronic Active 2 (4%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Liver (58) (58) (57) (57)
Angiectasis 1 (2%) 13 (22%) 8 (14%) 5 (9%)
Basophilic Focus 1 (2%) 3 (5%)
Clear Cell Focus 1 (2%) 1 (2%)
Eosinophilic Focus 5 (9%) 14 (24%) 16 (28%) 12 (21%)
Fatty Change 3 (5%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 19 (33%) 13 (23%) 16 (28%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infarct, Chronic 1 (2%)
Infiltration Cellular, Mixed Cell 9 (16%) 12 (21%) 12 (21%) 4 (7%)
Inflammation, Suppurative 1 (2%)
Mixed Cell Focus 3 (5%) 1 (2%) 2 (4%)
Necrosis, Coagulative, Multifocal 4 (7%) 12 (21%) 8 (14%) 8 (14%)
Thrombosis 1 (2%) 1 (2%)
Centrilobular, Necrosis 3 (5%) 1 (2%)
Hepatocyte, Karyomegaly 1 (2%)
Serosa, Fibrosis 1 (2%) 1 (2%)
Mesentery (10) (14) (7) (7)
Angiectasis 1 (10%)
Cyst 1 (7%)
Hyperplasia, Lymphoid 1 (14%)
Mineralization 1 (14%)
Fat, Hemorrhage 1 (7%)
Fat, Necrosis 8 (80%) 9 (64%) 6 (86%) 6 (86%)
Mesothelium, Inflammation, Chronic Active 1 (10%)
Pancreas (58) (57) (54) (57)
Fibrosis 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 3 (5%)
Acinus, Atrophy 1 (2%) 1 (2%) 3 (6%)
Acinus, Vacuolization Cytoplasmic 1 (2%)
Duct, Ectasia 1 (2%)
Salivary Glands (58) (58) (57) (58)
Infiltration Cellular, Mononuclear Cell 23 (40%) 9 (16%) 13 (23%) 3 (5%)
Inflammation, Focal, Suppurative 1 (2%)
Stomach, Forestomach (58) (58) (57) (57)
Hyperplasia, Squamous 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 4 (7%) 4 (7%)
Serosa, Inflammation, Chronic Active 1 (2%)
Stomach, Glandular (58) (58) (55) (55)
Mineralization 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Tooth (2) (3)
Dysplasia 1 (50%) 2 (67%)
Peridontal Tissue, Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (58) (57) (58)
Cardiomyopathy 2 (3%)
Polyarteritis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (57) (57) (57)
Cyst 1 (2%) 1 (2%)
Degeneration, Fatty 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Capsule, Hyperplasia 50 (86%) 55 (96%) 52 (91%) 50 (88%)
Capsule, Mineralization 1 (2%)
X-Zone, Vacuolization Cytoplasmic 2 (3%) 2 (4%) 4 (7%) 3 (5%)
Adrenal Medulla (58) (57) (57) (56)
Angiectasis 1 (2%)
Islets, Pancreatic (58) (55) (54) (57)
Hyperplasia 1 (2%)
Pituitary Gland (56) (55) (54) (56)
Pars Distalis, Angiectasis 2 (4%)
Pars Distalis, Congestion 2 (4%) 2 (4%)
Pars Distalis, Cyst 3 (5%) 1 (2%)
Pars Distalis, Hyperplasia 6 (11%) 3 (5%) 2 (4%) 5 (9%)
Thyroid Gland (58) (58) (56) (56)
Inflammation, Focal 1 (2%) 1 (2%)
Polyarteritis 1 (2%)
Ultimobranchial Cyst 2 (3%) 2 (3%) 3 (5%) 2 (4%)
Follicle, Cyst 2 (3%) 2 (3%)
Follicular Cell, Hyperplasia 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (51) (51) (47) (48)
Ectasia 1 (2%)
Infiltration Cellular, Mononuclear Cell 2 (4%) 1 (2%) 1 (2%)
Ovary (57) (57) (55) (56)
Abscess 1 (2%)
Atrophy 2 (4%) 4 (7%) 5 (9%) 2 (4%)
Congestion 1 (2%) 2 (4%) 1 (2%)
Cyst 14 (25%) 28 (49%) 16 (29%) 20 (36%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Pigmentation, Hemosiderin, Cholesterol 1 (2%)
Pigmentation, Lipofuscin 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Polyarteritis 1 (2%)
Uterus (58) (58) (55) (57)
Dilatation 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Necrosis 1 (2%)
Endometrium, Hyperplasia, Cystic 27 (47%) 27 (47%) 28 (51%) 31 (54%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (58) (56) (57)
Hyperplasia, Erythrocyte 2 (3%) 2 (4%)
Hyperplasia, Neutrophil 2 (3%) 1 (2%) 1 (2%) 2 (4%)
Lymph Node (5) (6) (5) (6)
Axillary, Hyperplasia, Lymphoid 1 (20%)
Iliac, Angiectasis 1 (17%)
Iliac, Hyperplasia, Lymphoid 1 (17%) 1 (20%)
Iliac, Inflammation, Chronic Active 1 (17%)
Lumbar, Hyperplasia, Lymphoid 1 (20%)
Pancreatic, Hyperplasia, Histiocytic 1 (20%)
Pancreatic, Hyperplasia, Lymphoid 1 (17%) 1 (20%) 1 (17%)
Renal, Hemorrhage 1 (17%) 2 (33%)
Renal, Hyperplasia, Lymphoid 1 (17%)
Lymph Node, Bronchial (47) (44) (49) (46)
Congestion 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 3 (7%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 5 (11%) 3 (6%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Inflammation 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mandibular (46) (39) (43) (38)
Hemorrhage 1 (3%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%) 1 (3%)
Hyperplasia, Lymphoid 2 (4%) 2 (5%) 2 (5%) 1 (3%)
Hyperplasia, Plasma Cell 1 (3%) 1 (3%)
Inflammation 1 (2%)
Lymph Node, Mesenteric (53) (50) (51) (53)
Angiectasis 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%) 3 (6%)
Hyperplasia, Lymphoid 5 (10%) 4 (8%) 2 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Chronic Active 2 (4%)
Lymph Node, Mediastinal (35) (42) (43) (36)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%) 2 (6%)
Hematopoietic Cell Proliferation 1 (3%)
Hemorrhage 4 (9%)
Hyperplasia, Histiocytic 2 (5%)
Hyperplasia, Lymphoid 2 (6%) 2 (5%) 5 (12%)
Hyperplasia, Plasma Cell 1 (3%)
Inflammation 1 (3%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Spleen (58) (58) (56) (57)
Hematopoietic Cell Proliferation 20 (34%) 43 (74%) 45 (80%) 44 (77%)
Hyperplasia, Lymphoid 2 (3%) 3 (5%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Pigmentation, Melanin 1 (2%)
Capsule, Hematocyst 1 (2%)
Thymus (56) (52) (49) (48)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (56) (54) (56)
Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Skin (57) (58) (57) (58)
Congestion 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (57) (58)
Fracture Healed 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (58) (56) (58)
Compression 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Mineralization 24 (41%) 10 (17%) 15 (27%) 25 (43%)
Ventricle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (58) (57) (57)
Congestion 2 (3%) 1 (2%)
Embolus, Focal 1 (2%)
Hemorrhage 3 (5%) 5 (9%) 6 (11%) 3 (5%)
Inflammation, Chronic 2 (4%)
Pigmentation, Hemosiderin 2 (3%) 3 (5%)
Pigmentation, Hemoglobin 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 2 (4%) 3 (5%)
Interstitium, Infiltration Cellular, Mixed
Cell 3 (5%) 1 (2%)
Nose (57) (58) (55) (55)
Inflammation, Suppurative 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Respiratory Epithelium, Cytoplasmic
Alteration 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (4) (6) (4) (8)
Hyperplasia 2 (33%) 3 (75%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (58) (57) (57)
Hemorrhage 1 (2%)
Infarct, Chronic 2 (3%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 5 (9%) 3 (5%) 4 (7%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Nephropathy 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Polyarteritis 1 (2%)
Glomerulus, Amyloid Deposition 1 (2%)
Pelvis, Infiltration Cellular, Mononuclear
Cell 1 (2%)
Renal Tubule, Dilatation 1 (2%)
Urinary Bladder (55) (53) (53) (46)
Hyperplasia, Lymphoid 4 (7%) 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Metaplasia, Squamous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 58 58 58 58
Scheduled Sacrifice 10 10 10 10
Early Deaths
Natural Death 4 13 20 20
Moribund Sacrifice 6 24 26 27
Survivors
Terminal Sacrifice 38 11 2 1
Animals Examined Microscopically 58 58 58 58
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (51) (43) (41) (37)
Inflammation, Chronic Active 1 (3%)
Intestine Large, Colon (57) (52) (51) (49)
Diverticulum 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (56) (50) (44) (44)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Intestine Small, Ileum (56) (48) (45) (46)
Peyer's Patch, Inflammation, Chronic Active 1 (2%)
Liver (58) (58) (58) (58)
Angiectasis 7 (12%) 15 (26%) 15 (26%)
Basophilic Focus 1 (2%) 1 (2%) 5 (9%) 4 (7%)
Clear Cell Focus 1 (2%) 2 (3%) 1 (2%)
Eosinophilic Focus 1 (2%) 6 (10%) 10 (17%) 7 (12%)
Fatty Change 6 (10%) 1 (2%) 1 (2%) 1 (2%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 5 (9%)
Hemorrhage 1 (2%) 1 (2%)
Infarct 1 (2%) 6 (10%) 2 (3%) 5 (9%)
Infiltration Cellular, Mixed Cell 1 (2%) 5 (9%) 4 (7%) 5 (9%)
Mixed Cell Focus 3 (5%) 3 (5%) 6 (10%) 3 (5%)
Necrosis, Coagulative, Multifocal 5 (9%) 4 (7%) 13 (22%) 12 (21%)
Thrombosis 1 (2%) 3 (5%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Regeneration 1 (2%)
Mesentery (2) (3) (2) (7)
Angiectasis 1 (14%)
Fat, Hemorrhage 2 (29%)
Fat, Necrosis 1 (50%) 2 (67%) 1 (50%) 3 (43%)
Pancreas (58) (58) (56) (55)
Granuloma 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Duct, Ectasia 1 (2%)
Salivary Glands (58) (58) (58) (58)
Infiltration Cellular, Mononuclear Cell 11 (19%) 9 (16%) 1 (2%) 6 (10%)
Stomach, Forestomach (58) (58) (56) (56)
Foreign Body 1 (2%)
Granuloma 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Focal 1 (2%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 2 (3%) 3 (5%) 2 (4%) 4 (7%)
Serosa, Inflammation 1 (2%)
Stomach, Glandular (58) (58) (56) (55)
Foreign Body 1 (2%)
Necrosis 2 (4%)
Tooth (2) (2) (4) (8)
Dysplasia 1 (50%) 1 (50%) 3 (38%)
Inflammation, Suppurative 1 (50%) 4 (100%) 5 (63%)
Peridontal Tissue, Proliferation Connective
Tissue 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (58) (58) (58)
Cardiomyopathy 2 (3%) 2 (3%)
Fibrosis 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (58) (57) (58)
Accessory Adrenal Cortical Nodule 1 (2%)
Cyst 1 (2%)
Hyperplasia 1 (2%) 3 (5%)
Capsule, Hyperplasia 35 (60%) 30 (52%) 31 (54%) 22 (38%)
Islets, Pancreatic (58) (58) (56) (55)
Hyperplasia 2 (3%) 1 (2%) 8 (14%) 3 (5%)
Pituitary Gland (57) (53) (53) (54)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 1 (2%)
Pars Intermedia, Hemorrhage 1 (2%)
Thyroid Gland (58) (58) (57) (57)
Ultimobranchial Cyst 1 (2%) 2 (4%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2) (2)
Infiltration Cellular, Mononuclear Cell 1 (50%)
Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (58) (58) (58) (58)
Granuloma Sperm 1 (2%)
Hemorrhage 1 (2%)
Preputial Gland (58) (58) (56) (58)
Atrophy 1 (2%)
Ectasia 2 (3%) 6 (10%) 2 (4%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 7 (12%) 7 (12%) 8 (14%) 3 (5%)
Inflammation, Chronic 5 (9%) 5 (9%) 4 (7%) 1 (2%)
Inflammation, Suppurative 1 (2%) 4 (7%) 10 (18%) 3 (5%)
Prostate (56) (54) (54) (53)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Seminal Vesicle (58) (57) (57) (54)
Dilatation 4 (7%) 1 (2%) 2 (4%)
Hyperplasia 1 (2%)
Inflammation, Chronic 2 (3%) 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Testes (58) (58) (58) (58)
Atrophy, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (58) (57) (57)
Hyperplasia, Neutrophil 2 (3%) 1 (2%) 3 (5%) 2 (4%)
Lymph Node (3) (1) (2)
Iliac, Hemorrhage 1 (50%)
Iliac, Hyperplasia, Lymphoid 1 (33%)
Iliac, Hyperplasia, Plasma Cell 2 (100%)
Iliac, Pigmentation, Hemosiderin 1 (50%)
Renal, Hyperplasia, Lymphoid 1 (33%)
Lymph Node, Bronchial (42) (42) (43) (33)
Hemorrhage 2 (5%)
Hyperplasia, Lymphoid 2 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mandibular (44) (37) (38) (42)
Congestion 1 (3%)
Hemorrhage 1 (2%)
Hyperplasia, Histiocytic 1 (3%) 2 (5%)
Hyperplasia, Lymphoid 1 (3%) 1 (3%)
Hyperplasia, Plasma Cell 1 (2%)
Pigmentation, Hemosiderin 2 (5%) 1 (3%)
Lymph Node, Mesenteric (57) (52) (51) (50)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Histiocytic 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Lymph Node, Mediastinal (37) (39) (40) (36)
Congestion 1 (3%)
Hematopoietic Cell Proliferation 1 (3%)
Hemorrhage 3 (8%) 2 (6%)
Hyperplasia, Histiocytic 1 (3%) 2 (6%)
Hyperplasia, Lymphoid 1 (3%) 1 (3%)
Spleen (58) (58) (56) (56)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 16 (28%) 36 (62%) 46 (82%) 45 (80%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Pigmentation, Melanin 2 (3%)
Thymus (51) (49) (44) (46)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (58) (57) (58) (58)
Acanthosis 1 (2%)
Atrophy 1 (2%)
Inflammation, Chronic 2 (3%) 5 (9%) 2 (3%) 3 (5%)
Inflammation, Suppurative 1 (2%)
Ulcer 2 (3%) 4 (7%) 5 (9%)
Prepuce, Acanthosis 1 (2%) 2 (4%)
Prepuce, Inflammation, Chronic 2 (4%)
Prepuce, Inflammation, Suppurative 1 (2%)
Prepuce, Pigmentation, Melanin 1 (2%)
Prepuce, Ulcer 1 (2%) 1 (2%)
Subcutaneous Tissue, Congestion 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (58) (58)
Fracture 1 (2%)
Sternum, Developmental Malformation 2 (3%)
Sternum, Fracture Healed 1 (2%)
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NERVOUS SYSTEM
Brain (58) (58) (58) (58)
Hemorrhage 1 (2%) 1 (2%)
Mineralization 28 (48%) 19 (33%) 15 (26%) 30 (52%)
Necrosis, Liquifactive 2 (3%)
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RESPIRATORY SYSTEM
Larynx (57) (58) (56) (56)
Cytoplasmic Alteration 1 (2%)
Exudate, Mucopurulent 2 (4%) 2 (4%)
Hemorrhage 1 (2%)
Metaplasia, Squamous 2 (4%)
Lung (58) (58) (58) (58)
Congestion 2 (3%) 5 (9%) 1 (2%)
Crystals 1 (2%)
Hemorrhage 6 (10%) 4 (7%) 2 (3%) 1 (2%)
Infarct 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Alveolus, Hemorrhage, Multifocal 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 4 (7%) 5 (9%) 1 (2%) 1 (2%)
Interstitium, Infiltration Cellular, Mixed
Cell 1 (2%)
Nose (58) (57) (56) (57)
Inflammation, Suppurative 1 (2%) 3 (5%) 1 (2%)
Proliferation Connective Tissue, Multifocal 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Respiratory Epithelium, Cytoplasmic
Alteration 1 (2%)
Respiratory Epithelium, Degeneration 1 (2%)
Vomeronasal Organ, Hypertrophy 1 (2%)
Trachea (57) (57) (56) (56)
Cytoplasmic Alteration 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05132-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 01:15:16
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 312 PPM 625 PPM 1250 PPM
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SPECIAL SENSES SYSTEM
Eye (1) (2)
Degeneration, Diffuse 1 (50%)
Phthisis Bulbi 1 (50%)
Retinal Detachment 1 (50%)
Cornea, Inflammation, Chronic 1 (50%)
Harderian Gland (7) (10) (5) (7)
Hyperplasia 1 (20%) 1 (14%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (58) (58) (58)
Cyst 2 (3%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Mononuclear Cell 3 (5%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (3%)
Inflammation, Suppurative 2 (3%)
Nephropathy 35 (60%) 15 (26%) 10 (17%) 19 (33%)
Bilateral, Pelvis, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Dilatation 4 (7%) 22 (38%) 46 (79%)
Renal Tubule, Karyomegaly 1 (2%) 2 (3%) 14 (24%) 38 (66%)
Urinary Bladder (58) (53) (53) (52)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic Active 2 (3%) 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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