TDMS Study 05132-06 Pathology Tables
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
Core Animals
Facility: Battelle Northwest
Chemical CAS #: 116-14-3
Lock Date: 10/14/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|
| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + A + + + I + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + A + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Capsule, Adenoma | X |
Capsule, Carcinoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + + + M + + + + + + + + + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + + + + + + + + + + + M|
Histiocytic Sarcoma | |
Pars Distalis, Adenoma | X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|
| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + M + M + + + + + + + + + + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cystadenoma | X |
Histiocytic Sarcoma | |
Luteoma | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Polyp Stromal | |
Cervix, Granular Cell Tumor NOS | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Axillary, Histiocytic Sarcoma | |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant Mixed | X |
Lumbar, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + M + + + + + + + + M + + + + M + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + M + + + + M + + + M + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + I + + + + + + + + + + + + M + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + M M M + M M M + + + + + + + M + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + I|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|
DAY ON TEST | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|
| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Carcinoma, Metastatic, Mammary Gland | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + M + + + A + + + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Carcinoma | X | 4 |
Hepatocellular Adenoma | X X X X X X | 14 |
Hepatocellular Adenoma, Multiple | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
Capsule, Adenoma | | 1 |
Capsule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M M M + M M M M + M M + + + + M M + + | 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X | 4 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + + + M + + + + + + | 42 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Cystadenoma | X | 2 |
Histiocytic Sarcoma | X | 1 |
Luteoma | | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
Polyp Stromal | X | 1 |
Cervix, Granular Cell Tumor NOS | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 5 |
Axillary, Histiocytic Sarcoma | X | 1 |
Iliac, Histiocytic Sarcoma | X | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M + + + + + + + + + + + I + M + + + | 40 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + M + + + + M M + + | 39 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + I + + + + I + + + + + + + + + + + | 43 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + M + M M + M M + + I M M + M + M + + + | 28 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + | 46 |
Lymphoma Malignant Mixed | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Astrocytoma NOS | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X X | 2 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Adenoma | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6| | |
DAY ON TEST | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6| | |
| 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | L |
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + A A + + + + M A + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + A + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + A + + + + + A + + + + + + A|
Sarcoma | X |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + A A + + + + + A + + + + + A + + + + I + A|
Sarcoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + A A + + + + + A + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + + + + A + + + + + A + + + + + + A|
Leiomyosarcoma, Metastatic, Uterus | X |
Sarcoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X X X |
Hemangioma, Multiple | X |
Hemangiosarcoma | X X X X X X X X X X X |
Hemangiosarcoma, Multiple | X X |
Hepatocellular Carcinoma | X X X X X X X X X X X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X |
Histiocytic Sarcoma | X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Sarcoma | X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Leiomyosarcoma, Metastatic, Uterus | X |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Leiomyosarcoma, Metastatic, Uterus | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Uterus | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Uterus | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + I + + + + + + + + + + + + + + + + + + I|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + M M M M + + + M + M + + M + M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + I + + + M + + + + + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Sarcoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Lymph Node | |
Iliac, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Renal, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + I + + M + M + + M M + + + + + + + + M + M + M|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | |
Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + I + M + M + + + + M + + M + M + + M M M + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + I + + M + + + M + + + + + + + + + + M + + + M +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + M M + + + M M + + M + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Sarcoma | X |
__________________________________________________________________________|
Thymus | + + + + M M + + + M + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Leiomyosarcoma, Metastatic, | |
Uterus | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Leiomyosarcoma, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|
DAY ON TEST | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|
| 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
312 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Histiocytic Sarcoma | X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Sarcoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + + + + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + A A + + + + + + + + + + + + A|
Leiomyosarcoma, Metastatic, Uterus | X |
Lymphoma Malignant Lymphocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M A + + + + + A + + + + A + + + A + | 36 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + | 45 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + A + + + + + | 42 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + A + + + + + | 39 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + + + + + A + + + A + + + + + | 37 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + A A + + + + + + + + + + A + + + + + | 39 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemangioma | X | 4 |
Hemangioma, Multiple | | 1 |
Hemangiosarcoma | X X X X X X X X | 19 |
Hemangiosarcoma, Multiple | X X X X X X | 8 |
Hepatocellular Carcinoma | X X X X X X X X X X | 23 |
Hepatocellular Carcinoma, Multiple | X X X | 5 |
Hepatocellular Adenoma | X X X X X | 10 |
Hepatocellular Adenoma, Multiple | X X | 7 |
Histiocytic Sarcoma | X X X X X X X X X X X | 21 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 13 |
Hemangiosarcoma | X | 2 |
Histiocytic Sarcoma | X | 1 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + I + + + + | 47 |
Histiocytic Sarcoma | | 2 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X | 1 |
Histiocytic Sarcoma | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M + + + + | 45 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + M + + + M M M M + + + + M M + + + + | 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + | 45 |
Pars Distalis, Adenoma | X X X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + M + M + + + + M + | 42 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | X X | 5 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 6 |
Iliac, Histiocytic Sarcoma | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Renal, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + + M + + + + + M + M + + + + | 36 |
Histiocytic Sarcoma | X X | 4 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + I + + M + + + + + + M + + + + + | 35 |
Histiocytic Sarcoma | X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + M + + + + + + + + M + + + + + | 40 |
Histiocytic Sarcoma | X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I + + + + I + I M + + + M + + + + M + + + + + | 35 |
Histiocytic Sarcoma | X X X X X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X X X | 7 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + I + + + M + + + + + + + + + + + + + + M + + | 42 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + I + + + + + + | 46 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Rib, Leiomyosarcoma, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Uterus | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 8 |
Histiocytic Sarcoma | X X X X X X X X X | 16 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 6 |
Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X X X X | 7 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + | 43 |
Leiomyosarcoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X X X X X X X X X X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6| | |
DAY ON TEST | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3| | |
| 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
312 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | L |
| 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|
| 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + A + + + + + M + M + + + + + + A A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangioma, Multiple | X |
Hemangiosarcoma | X X X X X X X X |
Hemangiosarcoma, Multiple | X X X|
Hepatocellular Carcinoma | X X X X X X X X X X|
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X X|
Hepatocellular Adenoma, Multiple | X X X |
Histiocytic Sarcoma | X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A A + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M M M M + M M M M + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + M + + M + + +|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|
| 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + M M + + + + + M M + + + M + M + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Periovarian Tissue, Histiocytic | |
Sarcoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + A A + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Histiocytic Sarcoma | |
Pancreatic, Histiocytic Sarcoma | X |
Renal, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + M|
Histiocytic Sarcoma | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + I + + + + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + M + M A + +|
Hemangioma | |
Histiocytic Sarcoma | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + M + + M + + + + M + + + + M + + + + M|
Histiocytic Sarcoma | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + +|
Histiocytic Sarcoma | X X X X |
__________________________________________________________________________|
Thymus | + M + + + + + + I + + + + + + + + + + + M + M +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + M + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|
DAY ON TEST | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|
| 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Histiocytic Sarcoma | X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Urinary Bladder | + + I + + + + + + + + + + + + M + + + + A A + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5| | |
DAY ON TEST | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5| | |
| 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
625 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + A M + A + + + + A + + + + + A + A + + + + A | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + A + + + + A | 42 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + A + + + + + + A | 42 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + A + A + + + + A | 40 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + A + + + + + A + A + + + + A | 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + A + A + + + + A | 39 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + A + A + + + + A | 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemangioma | X | 1 |
Hemangioma, Multiple | | 1 |
Hemangiosarcoma | X X X X X X X | 15 |
Hemangiosarcoma, Multiple | X X X X X X X X X | 12 |
Hepatocellular Carcinoma | X X X X X | 15 |
Hepatocellular Carcinoma, Multiple | X X X X X | 7 |
Hepatocellular Adenoma | X X X X X | 11 |
Hepatocellular Adenoma, Multiple | X X X X X X | 9 |
Histiocytic Sarcoma | X X X X X X | 19 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 7 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + | 44 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Tooth | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + + M + + + M + + M + M M | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 44 |
Pars Distalis, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5| | |
DAY ON TEST | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5| | |
| 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
625 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + + + + + M + + + + M + + | 38 |
__________________________________________________________________________|____________|
Ovary | + + + + M M + + + + + + + + + + + + + + + + + | 45 |
Histiocytic Sarcoma | X X | 4 |
Periovarian Tissue, Histiocytic | | |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Histiocytic Sarcoma | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Iliac, Histiocytic Sarcoma | X | 1 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Renal, Histiocytic Sarcoma | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + M M + + + + + + + + A + + + + M | 40 |
Histiocytic Sarcoma | X X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + M + + + + + + + + I M + M + M + M + + + | 34 |
Histiocytic Sarcoma | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + I + A + + + + + + + | 41 |
Hemangioma | X | 1 |
Histiocytic Sarcoma | X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M M + + + + + + + + M + + M + + M + | 35 |
Histiocytic Sarcoma | X X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Histiocytic Sarcoma | X X X X | 8 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + M M I + + + + + + + | 39 |
Histiocytic Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemangioma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5| | |
DAY ON TEST | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5| | |
| 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
625 PPM | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | L |
| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A + + + + + + + + + + + + + A + + + + + + + | 43 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X | 6 |
Histiocytic Sarcoma | X X X X X | 13 |
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 43 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | X X X X X X | 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|
DAY ON TEST | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|
| 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + A + + A + + A + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M A + + + I + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + A A + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + A + + + + + A + + A + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A A + A + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + A A + A + + A + + A + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X X X X X X X X X |
Hemangiosarcoma, Multiple | X X X X X X X X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Histiocytic Sarcoma | X X X X X X X X X X X |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Mesentery | + + + + |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Tooth | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + A + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + I + A + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|
DAY ON TEST | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|
| 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + M + + + + M + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +|
Cystadenoma | |
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + A + + + + + + + + + + + +|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Histiocytic Sarcoma | |
Pancreatic, Histiocytic Sarcoma | X |
Renal, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + M + M + + M + + + + + M|
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M A M M + + + M + + + + + +|
Histiocytic Sarcoma | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + A + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M + M M + + + + M M + + + M + + + + + M M +|
Histiocytic Sarcoma | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X X X X |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Thymus | I + + + + I + + + + + + + + M + + + + + + + + + M|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|
DAY ON TEST | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|
| 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1250 PPM | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + A + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Hemangiosarcoma, Metastatic, Liver | X |
Hemangiosarcoma, Metastatic, Pancreas| X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Histiocytic Sarcoma | X X X X X X X X X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + I + A + I +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X X X X X X X X |
Lymphoma Malignant Mixed | X X|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + A A A + + + A M M + A A + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + A + + + + + A + + + A A + + | 40 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + A + + + A + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + A + A + + + A + A + A A + + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + A A + + + + A A + + A A + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + A A A + + + A A + + A A + + | 35 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + A + A + + + A A + + A A + + | 35 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemangioma | X | 1 |
Hemangiosarcoma | X X X X X X X X X X | 19 |
Hemangiosarcoma, Multiple | X X X X X X X | 15 |
Hepatocellular Carcinoma | X X X X X X X | 13 |
Hepatocellular Carcinoma, Multiple | X X X X X | 7 |
Hepatocellular Adenoma | X X X X | 8 |
Hepatocellular Adenoma, Multiple | X X X X | 7 |
Histiocytic Sarcoma | X X X X X X X | 18 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M M M + + + M + M + + M M M M M + + M | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + | 46 |
Pars Distalis, Adenoma | X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + M M + + + M + + + + + + M + + + + + | 39 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + A + + | 46 |
Cystadenoma | X X | 2 |
Histiocytic Sarcoma | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 6 |
Iliac, Histiocytic Sarcoma | X | 1 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Renal, Histiocytic Sarcoma | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + M + + + + + + M M + M + + + + + | 38 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + M + + + + M M M + + + + M + + + M M M | 32 |
Histiocytic Sarcoma | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + + + M + + + M + + + + + + + + | 43 |
Histiocytic Sarcoma | X X | 6 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + M + + + M + + + + + M + + M + + | 33 |
Histiocytic Sarcoma | X X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | X X | 9 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | M M + + + M + + + + + + + + M + M + + + + + M | 38 |
Histiocytic Sarcoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + + + + + + + M + + + + + + | 46 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Sarcoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + | 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Alveolar/Bronchiolar Adenoma | X X X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hemangiosarcoma, Metastatic, Liver | X X | 3 |
Hemangiosarcoma, Metastatic, Pancreas| | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 4 |
Histiocytic Sarcoma | X X X X | 13 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + M + + + + + + A + + | 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
Adenoma | X X X | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + A + A + + + A + + + M + M I | 37 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6| | |
DAY ON TEST | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1| | |
| 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | L |
| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | X X X X X X X | 18 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + A + + + + + + + M + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + I + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + M + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + M + M M + + + M + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | A |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Deep Cervical, Lymphoma Malignant | |
Mixed | X |
Iliac, Lymphoma Malignant Mixed | X X |
Lumbar, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + + + + + + M + + + + + + + + M M + M M|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + I + + + + + M M M + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + M + + + M + + + + + + M + + + M + + M M +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X |
Carcinoma, Metastatic, Harderian | |
Gland | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | M + |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M M + + + + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hepatocellular Carcinoma | X X X X | 7 |
Hepatocellular Carcinoma, Multiple | X X | 4 |
Hepatocellular Adenoma | X X X X X X X X | 11 |
Hepatocellular Adenoma, Multiple | X X | 6 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M M + + + M M M M + + + + M + + | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + | 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + I + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Deep Cervical, Lymphoma Malignant | | |
Mixed | | 1 |
Iliac, Lymphoma Malignant Mixed | | 2 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + + + M M + + + + + M + + + + + + + | 36 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + M + M + + M + + + + + + + M + M + + + | 36 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + | 47 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + M + + + + M M M M + + + M + + + + M | 30 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemangiosarcoma | X | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + + + + + + + + + + + M + + | 43 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
DAY ON TEST | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X X | 9 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 6 |
Adenoma | X X X | 5 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|
| 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
312 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + A A A + + + A A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + A A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A A A + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Hemangioma | X |
Hemangioma, Multiple | X X X X X X|
Hemangiosarcoma | X X X |
Hemangiosarcoma, Multiple | X X X X X X X X X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X X X|
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X X X X X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | +|
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M + M + M M M + + M + + M + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|
| 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
312 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | |
Carcinoma, Metastatic, Lung | |
Hemangioma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | M + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + |
Renal, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + I M + + + + M + + + + M + + M + + + + + + + + +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + M + + + M + + + + + + + M + M M +|
Histiocytic Sarcoma | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + I + +|
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M M + + + + + M + + + + + + M + + + + M + M|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + M + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|
| 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
312 PPM | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + A + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5| | |
DAY ON TEST | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9| | |
| 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
312 PPM | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | L |
| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + A + M + + + M + + A A + + + A + A + + + + + | 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + A + + + + + + A + + + + + + + + + + + + | 40 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + A + + A A + + + + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + + + + + A + + + + + + + + + + + + | 40 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + + + A A + + + + + + + + + + + | 39 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Lung | X | 1 |
Hemangioma | X X | 3 |
Hemangioma, Multiple | X | 7 |
Hemangiosarcoma | X X | 5 |
Hemangiosarcoma, Multiple | X X X X X X X | 16 |
Hepatocellular Carcinoma | X X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X X X X X X X | 9 |
Hepatocellular Adenoma | X X X X | 11 |
Hepatocellular Adenoma, Multiple | X X X X | 6 |
Histiocytic Sarcoma | X X X X X | 12 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Capsule, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + I + + + + + + + + + + + + + + + + I + + + + | 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + + + + + + + M M M + M + M + M | 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5| | |
DAY ON TEST | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9| | |
| 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
312 PPM | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | L |
| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + M + + + M | 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Follicular Cell, Adenoma | X X | 3 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
Carcinoma, Metastatic, Lung | X | 1 |
Hemangioma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyosarcoma | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Renal, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + + + + M M + + M + + M + + + M + + + | 36 |
Histiocytic Sarcoma | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M M I + + M M + + + + M + + + + + + + M + | 34 |
Histiocytic Sarcoma | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | I I + + M + + + + + + + + + + M + + + + + + M | 42 |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M + + M M + + + M + + + + M + + + + + | 34 |
Carcinoma, Metastatic, Lung | X | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + M + + + + + I + + M + + + + | 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5| | |
DAY ON TEST | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9| | |
| 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
312 PPM | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | L |
| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M + M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Subcutaneous Tissue, Hemangioma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X X X | 4 |
Carcinoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X X X | 7 |
Histiocytic Sarcoma | X X X | 7 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 8 |
Adenoma | X X X X X | 7 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A M + + + + + + + + + A + + + + + + + + | 43 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X X X X X | 12 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|
DAY ON TEST | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|
| 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
625 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + A + M A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + A + + + + + + I + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + M + + A + + + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + A + + + + + + A + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X X |
Hemangioma, Multiple | X |
Hemangiosarcoma | X X X X |
Hemangiosarcoma, Multiple | X X X X X X X X X |
Hepatocellular Carcinoma | X X X X X X X X X X X X X|
Hepatocellular Carcinoma, Multiple | X X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Histiocytic Sarcoma | X X X |
__________________________________________________________________________|
Mesentery | + |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M M + + M M + + + + M M + M M I + M + + +|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|
DAY ON TEST | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|
| 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
625 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + |
Renal, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + M + + + + + + + + M M + + M M + + + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + M M M + I M + M + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + M + + M + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M + + M + M M M + + + M + M + + + + + M + I|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Thymus | + M + + + + M + M + + M + + M + + + + + + + M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Hemangiosarcoma, Metastatic, Liver | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X X X X X X |
Histiocytic Sarcoma | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|
DAY ON TEST | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|
| 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
625 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + + +|
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6| | |
DAY ON TEST | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4| | |
| 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
625 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | A M + + + + + + + + A M A A + A + + + A + A + | 31 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A A A A + + + + + + + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + A A + + + + + + + I + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + A A A A + A + + + + + A + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A + + + + + + + A + A A + A + + + A + A + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A A + + + + + + + A A A A + A + + + + + A + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + + + + + + + A A A A + A + + + + + A + | 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemangioma | X | 3 |
Hemangioma, Multiple | X | 2 |
Hemangiosarcoma | X X X X X X | 10 |
Hemangiosarcoma, Multiple | X X X X X X X X | 17 |
Hepatocellular Carcinoma | X X X X X X X X X X X | 24 |
Hepatocellular Carcinoma, Multiple | X X X X | 9 |
Hepatocellular Adenoma | X X | 5 |
Hepatocellular Adenoma, Multiple | X X X | 7 |
Histiocytic Sarcoma | X X X X | 7 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Tooth | + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + A + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + M + + + + + + M + + I + M + | 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + A + + + + + + + + M + | 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6| | |
DAY ON TEST | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4| | |
| 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
625 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Prostate | + + M + + + + + + + A M A + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
Hemangioma | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
Renal, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M + + + + + + A + + + M + I + + M + | 35 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + M + + M M + + M + + M + M + + I + I | 32 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + A A + + + + M + + + + | 41 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + I + + + + + + + + + A M + M + + M + + + M | 32 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M M + + + + A M + M M + + M + + + | 34 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Subcutaneous Tissue, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6| | |
DAY ON TEST | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4| | |
| 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
625 PPM | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X X X X X X X | 12 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Hemangiosarcoma, Metastatic, Liver | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 14 |
Histiocytic Sarcoma | X X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + A + A + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 5 |
Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
Histiocytic Sarcoma | X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + A + A + + + + + + + + A + | 43 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|
DAY ON TEST | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|
| 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + M + + + + + + M A M A + A M M A M M + A +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + A + A + + A + A + M +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + A + A + + + + A + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + A + A + + A + A + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + A + A + + A A A + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + A + + A + A + + A A A + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + A + A + + A A A + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | |
Hemangioma | |
Hemangioma, Multiple | X |
Hemangiosarcoma | X X X X X X X X X X X X |
Hemangiosarcoma, Multiple | X X X X X X X |
Hepatocellular Carcinoma | X X X X X X X X X X X X X|
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X|
Hepatocellular Adenoma, Multiple | X X X X |
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + |
Hemangioma | |
Hemangiosarcoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + A + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + A + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|
DAY ON TEST | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|
| 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + I + + + + + + + + + + M + M + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + M + + + M + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + A + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + A + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M M M M + + M + + + + + M I + + M M + I M +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + M M + + + M M M + + + + + M + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + M + A + + + M M + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + M M + M + I M + M + + M M + + M +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + A + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + M M + + + + + + + + + + + + + + + + + M M + M M|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
_____________________________________________________________________________________________________________________
| 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|
DAY ON TEST | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|
| 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Gland | |
__________________________________________________________________________|
Skeletal Muscle | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma | |
Carcinoma, Metastatic, Harderian | |
Gland | |
Hemangiosarcoma, Metastatic, Liver | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + A + A + + + + A + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + M M + M + + + + + A + + A M + + | 27 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + A + + + + + + + + + A + + | 39 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + A + + + + + + + + + A + + | 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + A + + + + + + + + + A + + | 39 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + A + A + + + + + + + + A A + + | 36 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + A + A + + + + + A + + A A + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + A + A + + + + + + + + A A + + | 36 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Hemangioma | X | 1 |
Hemangioma, Multiple | | 1 |
Hemangiosarcoma | X X X X X X X | 19 |
Hemangiosarcoma, Multiple | X X X X X X X X X X X | 18 |
Hepatocellular Carcinoma | X X X X X X X | 20 |
Hepatocellular Carcinoma, Multiple | X X X | 6 |
Hepatocellular Adenoma | X X X X X X X X | 13 |
Hepatocellular Adenoma, Multiple | X X X | 7 |
Histiocytic Sarcoma | X X X X | 7 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Hemangioma | X | 1 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + M + + + + + + + + + + + + | 45 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Tooth | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + | 45 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + M M + M + + + M + + + + + + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + A + A + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + A + A + + + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
Histiocytic Sarcoma | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M I M + + A + + + + M + M + M + + M | 26 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + M M + + + M + + + + + M + + + + + + | 34 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M A M + + + + + + + + + + + | 40 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M + M + + + + M + + + + + M M I M + + M | 29 |
Carcinoma, Metastatic, Lung | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Histiocytic Sarcoma | X X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | M + M + + + M + + + A + + + + M + + + + + + + | 37 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Carcinoma, Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + A + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma | X | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Hemangiosarcoma, Metastatic, Liver | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 8 |
Histiocytic Sarcoma | X X | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05132-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRAFLUOROETHYLENE Date: 03/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:11:12
__________________________________________________________________________________________________________________________________
| 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6| | |
DAY ON TEST | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3| | |
| 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | A |
1250 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 6 |
Adenoma | X X | 4 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Lung | X | 1 |
Histiocytic Sarcoma | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + A + + + + + + + + + + + + | 42 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | X X X X | 7 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
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---------- END OF REPORT ----------
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